JP2000515374A - 二つの共刺激経路を同時にブロックできる可溶性分子を用いたt細胞寛容の誘導 - Google Patents
二つの共刺激経路を同時にブロックできる可溶性分子を用いたt細胞寛容の誘導Info
- Publication number
- JP2000515374A JP2000515374A JP50683098A JP50683098A JP2000515374A JP 2000515374 A JP2000515374 A JP 2000515374A JP 50683098 A JP50683098 A JP 50683098A JP 50683098 A JP50683098 A JP 50683098A JP 2000515374 A JP2000515374 A JP 2000515374A
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.ヒトリンパ球の表面に置かれているヒトCD40抗原および少なくともヒト CD86抗原に結合することが可能な可溶性分子。 2.CD40に対する抗原結合部位およびCD86に対する抗原結合部位を有す る抗体である請求項1記載の可溶性結合分子。 3.特にCD40に対する抗体の抗原結合部位およびCD80およびCD86に 架橋反応性の抗体の抗原結合部位を含むことにより、CD40およびCD80と CD86との両方に結合することが可能な三特異的ジアボディーである請求項2 記載の抗体分子。 4.特にCD40に対する抗体の抗原結合部位およびCD86に対する抗体の抗 原結合部位を含むことにより、ヒトCD40およびヒトCD86に結合すること のできる二特異的ジアボディーである請求項2記載の抗体分子。 5.特にCD40に対する抗体の抗原結合部位、CD80に対する抗体の抗原結 合部位およびCD86に対する抗体の抗原結合部位を含むことにより、CD40 、CD80およびCD86に結合することのできる三特異的トリアボディーであ る請求項2に記載の抗体分子。 6.ヒトCTLA−4の細胞外領域により少なくともCD86に結合することの できる請求項1または3記載の可溶性結合分子。 7.CD86に対する抗体が抗体Fun−1である請求項4または5記載の抗体 。 8.CD40に対する抗体がCD40に対する拮抗性抗体である請求項2〜7の いずれか一項に記載の抗体。 9.CD40に対する抗体がCD40に対する非刺激拮抗性抗体である請求項2 〜7のいずれか1項に記載の抗体。 10.宿主細胞中で抗体分子を発現することのできる調節配列に作動可能に結合 された、請求項1〜9のいずれか1項に記載の結合分子断片をコードする核酸配 列を有する組換えベクター。 11.請求項9記載のベクターで安定に形質転換された宿主細胞。 12.宿主細胞を培養し、培養培地から結合分子を単離することからなる、ヒト CD40抗原および少なくともヒトCD86抗原に結合することのできる組換え 分子を作る方法。 13.請求項1〜9のいずれか1項に記載の治療効果量の結合分子および薬学的 に許容されるキャリヤーを含有する、T細胞寛容誘導のための医薬組成物。 14.請求項1〜9のいずれか1項に記載の治療効果量の医薬組成物を治療が必 要な患者に投与することからなる、T細胞仲介免疫応答を治療する方法。 15.請求項13記載の治療効果量の医薬組成物を治療が必要な患者に投与す ることからなる、同種移植片拒絶を妨げる方法。 16.請求項13記載の治療効果量の医薬組成物を治療が必要な患者に投与する ことからなる、異種移植片拒絶を妨げる方法。 17.請求項13記載の治療効果量の医薬組成物を治療が必要な患者に投与する ことからなる、T細胞寛容を誘導するための方法。 18.請求項13記載の治療効果量の医薬組成物を治療が必要な患者に投与する ことからなる、同種移植片または異種移植片寛容を誘導するための方法。 19.請求項13記載の治療効果量の医薬組成物を治療が必要な患者に投与する ことからなる、リュウマチ性関節炎、多硬化症および乾せん等の自己免疫疾患を 予防または治療するための方法。 20.請求項13記載の治療効果量の医薬組成物を治療が必要な患者に投与する ことからなる、遺伝子治療ベクターまたはビヒクルに対するT細胞仲介免疫応答 を治療する方法。 21.請求項13記載の治療効果量の医薬組成物を治療が必要な患者に投与する ことからなる、治療用分子に対するT細胞仲介免疫応答を治療する方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US2207096P | 1996-07-23 | 1996-07-23 | |
US60/022,070 | 1996-07-23 | ||
PCT/NL1997/000438 WO1998003670A1 (en) | 1996-07-23 | 1997-07-23 | Induction of t cell tolerance using a soluble molecule that can simultaneously block two costimulatory pathways |
Publications (3)
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JP2000515374A true JP2000515374A (ja) | 2000-11-21 |
JP2000515374A5 JP2000515374A5 (ja) | 2005-03-10 |
JP4219985B2 JP4219985B2 (ja) | 2009-02-04 |
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JP50683098A Expired - Fee Related JP4219985B2 (ja) | 1996-07-23 | 1997-07-23 | 二つの共刺激経路を同時にブロックできる可溶性分子を用いたt細胞寛容の誘導 |
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US (1) | US20020150559A1 (ja) |
EP (1) | EP0922111B1 (ja) |
JP (1) | JP4219985B2 (ja) |
AT (1) | ATE283925T1 (ja) |
CA (1) | CA2260752A1 (ja) |
DE (1) | DE69731836T2 (ja) |
HK (1) | HK1017905A1 (ja) |
WO (1) | WO1998003670A1 (ja) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
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EP0988321A2 (en) * | 1997-06-20 | 2000-03-29 | Innogenetics N.V. | B7-binding molecules for treating immune diseases |
EP1053006A4 (en) | 1998-02-04 | 2002-09-25 | Gen Hospital Corp | COSTIMULATORY BLOCKADE AND MIXED CHIMERISM IN TRANSPLANTATIONS |
FR2789089A1 (fr) * | 1999-02-02 | 2000-08-04 | Pf Medicament | Lymphocytes t humains effecteurs exprimant la molecule cd86 et possedant des proprietes immunodulatrices, costimulatrices et cytotoxiques, leurs procedes d'obtention et leurs applications |
JP2003510371A (ja) * | 1999-10-04 | 2003-03-18 | カイロン コーポレイション | 乾癬を処置するためのcd40アンタゴニスト |
EP1839674A1 (en) * | 1999-10-04 | 2007-10-03 | Novartis Vaccines and Diagnostics, Inc. | CD40 antagonist for treating psoriasis |
EP1274455A1 (en) * | 2000-04-19 | 2003-01-15 | Tanox, Inc. | Cd40 antagonists for use in treating psoriasis and other inflammatory skin conditions |
US20030059888A1 (en) * | 2001-08-22 | 2003-03-27 | Shengfeng Li | Compositions and methods for generating antigen-binding units |
US20070148162A1 (en) * | 2003-02-27 | 2007-06-28 | Ranjit Bhardwaj | Molecule which binds cd80 and cd86 |
WO2005018668A1 (en) * | 2003-08-25 | 2005-03-03 | Pangenetics B.V. | Method of inducing immune tolerance |
EP1854810A1 (en) | 2006-05-09 | 2007-11-14 | PanGenetics B.V. | Deimmunized antagonistic anti-human CD40 monoclonal antibody from the ch5D12 antibody |
CN101842387B (zh) | 2007-09-26 | 2014-05-07 | Ucb医药有限公司 | 双特异性抗体融合物 |
PL2334705T3 (pl) * | 2008-09-26 | 2017-06-30 | Ucb Biopharma Sprl | Produkty biologiczne |
KR20170091801A (ko) * | 2008-10-02 | 2017-08-09 | 압테보 리서치 앤드 디벨롭먼트 엘엘씨 | Cd86 길항제 다중-표적 결합 단백질 |
KR20180105736A (ko) * | 2008-10-10 | 2018-09-28 | 압테보 리서치 앤드 디벨롭먼트 엘엘씨 | Tcr 복합체 면역치료제 |
WO2013158856A2 (en) | 2012-04-20 | 2013-10-24 | Emergent Product Development Seattle, Llc | Cd3 binding polypeptides |
EP2948475A2 (en) * | 2013-01-23 | 2015-12-02 | AbbVie Inc. | Methods and compositions for modulating an immune response |
EP2883883A1 (en) | 2013-12-16 | 2015-06-17 | Cardio3 Biosciences S.A. | Therapeutic targets and agents useful in treating ischemia reperfusion injury |
EP2930188A1 (en) * | 2014-04-13 | 2015-10-14 | Affimed Therapeutics AG | Trifunctional antigen-binding molecule |
EP3954703A3 (en) | 2014-05-29 | 2022-05-18 | MacroGenics, Inc. | Tri-specific binding molecules and methods of use thereof |
JP7002446B2 (ja) | 2015-09-21 | 2022-03-04 | アプティーボ リサーチ アンド デベロップメント エルエルシー | Cd3結合ポリペプチド |
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CN108264561B (zh) * | 2016-12-30 | 2021-09-10 | 惠和生物技术(上海)有限公司 | 一种结合cd19、cd3和t细胞负共刺激分子的三功能分子及其应用 |
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US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
JPS5896026A (ja) * | 1981-10-30 | 1983-06-07 | Nippon Chemiphar Co Ltd | 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤 |
DE3380726D1 (en) * | 1982-06-24 | 1989-11-23 | Japan Chem Res | Long-acting composition |
US4766106A (en) * | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
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EP0672142B1 (en) * | 1992-12-04 | 2001-02-28 | Medical Research Council | Multivalent and multispecific binding proteins, their manufacture and use |
GB9412166D0 (en) * | 1993-09-22 | 1994-08-10 | Medical Res Council | Retargetting antibodies |
US6051228A (en) * | 1998-02-19 | 2000-04-18 | Bristol-Myers Squibb Co. | Antibodies against human CD40 |
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- 1997-07-23 CA CA 2260752 patent/CA2260752A1/en not_active Abandoned
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CA2260752A1 (en) | 1998-01-29 |
EP0922111A1 (en) | 1999-06-16 |
EP0922111B1 (en) | 2004-12-01 |
HK1017905A1 (en) | 1999-12-03 |
DE69731836T2 (de) | 2005-12-01 |
WO1998003670A1 (en) | 1998-01-29 |
US20020150559A1 (en) | 2002-10-17 |
ATE283925T1 (de) | 2004-12-15 |
DE69731836D1 (de) | 2005-01-05 |
JP4219985B2 (ja) | 2009-02-04 |
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