DK3421486T5 - Nye Vista-IG-konstruktioner og anvendelse af Vista-IG til behandling af autoimmune, allergiske og inflammatoriske lidelser - Google Patents
Nye Vista-IG-konstruktioner og anvendelse af Vista-IG til behandling af autoimmune, allergiske og inflammatoriske lidelser Download PDFInfo
- Publication number
- DK3421486T5 DK3421486T5 DK18173447.6T DK18173447T DK3421486T5 DK 3421486 T5 DK3421486 T5 DK 3421486T5 DK 18173447 T DK18173447 T DK 18173447T DK 3421486 T5 DK3421486 T5 DK 3421486T5
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- DK
- Denmark
- Prior art keywords
- vista
- autoimmune
- allergic
- constructs
- treatment
- Prior art date
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- 230000000172 allergic effect Effects 0.000 title 1
- 208000010668 atopic eczema Diseases 0.000 title 1
- 230000001363 autoimmune Effects 0.000 title 1
- 208000027866 inflammatory disease Diseases 0.000 title 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
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- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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EP13806673.3A EP2864352B1 (en) | 2012-06-22 | 2013-06-21 | Novel vista-ig constructs and the use of vista-ig for treatment of autoimmune, allergic and inflammatory disorders |
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US8231872B2 (en) | 2005-04-25 | 2012-07-31 | The Trustees Of Dartmouth College | Regulatory T cell mediator proteins and uses thereof |
US10745467B2 (en) | 2010-03-26 | 2020-08-18 | The Trustees Of Dartmouth College | VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders |
US20150231215A1 (en) | 2012-06-22 | 2015-08-20 | Randolph J. Noelle | VISTA Antagonist and Methods of Use |
AU2011230537C1 (en) * | 2010-03-26 | 2018-08-02 | Trustees Of Dartmouth College | Vista regulatory T cell mediator protein, vista binding agents and use thereof |
JP2014502258A (ja) | 2010-10-22 | 2014-01-30 | ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド | 免疫反応を抑制するためにプログラムされた制御性t細胞の発見 |
BR112014032276A2 (pt) * | 2012-06-22 | 2017-11-28 | King S College London | construtos de vista-ig e o uso de vista-ig para o tratamento de distúrbios autoimunes, alérgicos e inflamatórios |
US9890215B2 (en) | 2012-06-22 | 2018-02-13 | King's College London | Vista modulators for diagnosis and treatment of cancer |
CN105246507B (zh) * | 2012-09-07 | 2019-01-25 | 达特茅斯大学理事会 | 用于诊断和治疗癌症的vista调节剂 |
US10548957B2 (en) | 2012-09-28 | 2020-02-04 | Dana-Farber Cancer Institute, Inc. | Targeted expansion of Qa-1-peptide-specific regulatory CD8 T cells to ameliorate arthritis |
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AU2015228372B2 (en) | 2014-03-12 | 2018-05-31 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
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CN103923934B (zh) * | 2014-03-22 | 2016-11-02 | 复旦大学 | 一种具有免疫负调控作用的基因工程蛋白及其制备方法与应用 |
JP6997619B2 (ja) * | 2014-06-11 | 2022-01-17 | キャシー・エイ・グリーン | 液性免疫の抑制または増進のための、vistaアゴニスト及びvistaアンタゴニストの使用 |
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CN104257746A (zh) * | 2014-08-29 | 2015-01-07 | 山东科尔生物医药科技开发有限公司 | 一种含有壳寡糖的药物组合物及其制备方法和应用 |
JP6885728B2 (ja) * | 2014-11-06 | 2021-06-16 | キングス・カレッジ・ロンドン | Vistaアンタゴニスト及び使用の方法 |
JOP20150008B1 (ar) * | 2014-11-26 | 2021-08-17 | Janssen Pharmaceutica Nv | أجسام مضادة ل vista وأجزاء منها |
JP2018505911A (ja) | 2014-12-05 | 2018-03-01 | イミュネクスト,インコーポレーテッド | 推定上のvista受容体としてのvsig8の同定と、vista/vsig8調節剤を産生するためのその使用 |
JP6776254B2 (ja) | 2015-03-16 | 2020-10-28 | イッサム、リサーチ、デベロップメント、カンパニー、オブ、ザ、ヘブライ、ユニバーシティー、オブ、イエルサレム、リミテッドYissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | B7リガンド二量体界面に由来する単離されたペプチドおよびそれらの使用 |
WO2016196912A1 (en) * | 2015-06-03 | 2016-12-08 | Dana-Farber Cancer Institute, Inc. | Methods to induce conversion of regulatory t cells into effector t cells for cancer immunotherapy |
CA2990360C (en) | 2015-06-24 | 2024-02-13 | Janssen Pharmaceutica Nv | Anti-vista antibodies and fragments |
KR20180029079A (ko) | 2015-07-31 | 2018-03-19 | 유니버시티 오브 플로리다 리서치 파운데이션, 아이엔씨. | 암에 대한 면역 체크포인트 억제제와의 조합 요법에서의 조혈 줄기 세포 |
RU2769379C2 (ru) * | 2015-09-24 | 2022-03-30 | Дайити Санкио Компани, Лимитед | Антитело против garp |
WO2017058859A1 (en) | 2015-09-29 | 2017-04-06 | Celgene Corporation | Pd-1 binding proteins and methods of use thereof |
CN105506119A (zh) * | 2016-01-08 | 2016-04-20 | 张君 | 大鼠网膜脂肪组织炎症通路关键因子表达水平的测定方法 |
WO2017137830A1 (en) * | 2016-02-12 | 2017-08-17 | Janssen Pharmaceutica Nv | Anti-vista (b7h5) antibodies |
CA3056368A1 (en) * | 2016-03-15 | 2017-09-21 | Biomerica, Inc. | Compositions, devices, and methods of fibromyalgia sensitivity testing |
WO2017181139A2 (en) | 2016-04-15 | 2017-10-19 | Michael Molloy | Anti-human vista antibodies and use thereof |
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2013
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- 2013-06-21 CA CA2877533A patent/CA2877533C/en active Active
- 2013-06-21 DK DK18173447.6T patent/DK3421486T5/da active
- 2013-06-21 CN CN201380043664.XA patent/CN104619722B/zh active Active
- 2013-06-21 FI FIEP18173447.6T patent/FI3421486T3/fi active
- 2013-06-21 AU AU2013277051A patent/AU2013277051B2/en active Active
- 2013-06-21 TW TW108120104A patent/TWI705073B/zh active
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2015
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2017
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2020
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- 2020-07-30 US US16/943,413 patent/US20210147521A1/en active Pending
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CA2877533A1 (en) | 2013-12-27 |
JP2018021049A (ja) | 2018-02-08 |
US20210147521A1 (en) | 2021-05-20 |
EP2864352A4 (en) | 2016-05-25 |
BR112014032276A2 (pt) | 2017-11-28 |
TWI705073B (zh) | 2020-09-21 |
CA2877533C (en) | 2022-08-16 |
WO2013192504A1 (en) | 2013-12-27 |
US20140220012A1 (en) | 2014-08-07 |
EP2864352B1 (en) | 2018-08-08 |
JP2015526064A (ja) | 2015-09-10 |
JP2020096628A (ja) | 2020-06-25 |
TW201412775A (zh) | 2014-04-01 |
AU2013277051B2 (en) | 2018-06-07 |
JP6665139B2 (ja) | 2020-03-13 |
CN104619722B (zh) | 2022-10-04 |
FI3421486T3 (fi) | 2023-12-15 |
US20180051070A1 (en) | 2018-02-22 |
EP2864352A1 (en) | 2015-04-29 |
TW201936643A (zh) | 2019-09-16 |
HK1214272A1 (zh) | 2016-07-22 |
AU2013277051A1 (en) | 2015-02-12 |
EP3421486A1 (en) | 2019-01-02 |
EP3421486B1 (en) | 2023-09-27 |
DK3421486T3 (da) | 2023-12-04 |
TWI677507B (zh) | 2019-11-21 |
JP6285923B2 (ja) | 2018-02-28 |
CN104619722A (zh) | 2015-05-13 |
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