|
DE3163811D1
(en)
*
|
1980-02-29 |
1984-07-05 |
University Patents Inc |
Process for removing trityl blocking groups from 5'-o trityl nucleosides and oligonucleotides
|
|
US7101981B1
(en)
|
1980-08-26 |
2006-09-05 |
Regents Of The University Of California |
Bovine growth hormone recombinantly produced in E. coli
|
|
US6692941B1
(en)
*
|
1980-08-26 |
2004-02-17 |
The Regents Of The University Of California |
Bovine growth hormone
|
|
US4973679A
(en)
*
|
1981-03-27 |
1990-11-27 |
University Patents, Inc. |
Process for oligonucleo tide synthesis using phosphormidite intermediates
|
|
JPS58109498A
(ja)
*
|
1981-08-24 |
1983-06-29 |
Agency Of Ind Science & Technol |
オリゴリボヌクレオチド
|
|
EP0090789A1
(en)
*
|
1982-03-26 |
1983-10-05 |
Monsanto Company |
Chemical DNA synthesis
|
|
CA1223831A
(en)
|
1982-06-23 |
1987-07-07 |
Dean Engelhardt |
Modified nucleotides, methods of preparing and utilizing and compositions containing the same
|
|
DE3371098D1
(en)
*
|
1982-09-30 |
1987-05-27 |
Iro Ab |
Yarn storing, feeding and measuring device
|
|
DE3239887A1
(de)
*
|
1982-10-28 |
1984-05-03 |
Hubert Prof. Dr. 2000 Hamburg Köster |
Verfahren zur herstellung von oligonucleotiden
|
|
US5198540A
(en)
*
|
1982-10-28 |
1993-03-30 |
Hubert Koster |
Process for the preparation of oligonucleotides in solution
|
|
FR2544720B1
(fr)
*
|
1983-04-19 |
1987-11-27 |
California Inst Of Techn |
Installation perfectionnee et procede pour la synthese de composes chimiques, en particulier d'oligonucleotides
|
|
WO1984004749A1
(en)
*
|
1983-06-01 |
1984-12-06 |
Beckman Instruments Inc |
Novel preparation of nucleoside phosphoramidite intermediates
|
|
DE3329892A1
(de)
*
|
1983-08-18 |
1985-03-07 |
Köster, Hubert, Prof. Dr., 2000 Hamburg |
Verfahren zur herstellung von oligonucleotiden
|
|
USRE34069E
(en)
*
|
1983-08-18 |
1992-09-15 |
Biosyntech Gmbh |
Process for the preparation of oligonucleotides
|
|
US5166330A
(en)
*
|
1983-09-06 |
1992-11-24 |
Hoechst Aktiengesellschaft |
Process for the preparation of nucleoside alkyl-aralkyl- and aryl-phosphonites and -phosphonates
|
|
DE3332068A1
(de)
*
|
1983-09-06 |
1985-03-21 |
Hoechst Ag, 6230 Frankfurt |
Verfahren zur herstellung von nukleosidalkyl-, aralkyl- und arylphosphoniten und -phosphonaten
|
|
US5118800A
(en)
*
|
1983-12-20 |
1992-06-02 |
California Institute Of Technology |
Oligonucleotides possessing a primary amino group in the terminal nucleotide
|
|
US5015733A
(en)
*
|
1983-12-20 |
1991-05-14 |
California Institute Of Technology |
Nucleosides possessing blocked aliphatic amino groups
|
|
FR2556726B1
(fr)
*
|
1983-12-20 |
1987-02-20 |
California Inst Of Techn |
Compositions a base d'oligonucleotides monocatenaires et procede pour leur preparation
|
|
US5118802A
(en)
*
|
1983-12-20 |
1992-06-02 |
California Institute Of Technology |
DNA-reporter conjugates linked via the 2' or 5'-primary amino group of the 5'-terminal nucleoside
|
|
USRE43096E1
(en)
|
1984-01-16 |
2012-01-10 |
California Institute Of Technology |
Tagged extendable primers and extension products
|
|
US5821058A
(en)
|
1984-01-16 |
1998-10-13 |
California Institute Of Technology |
Automated DNA sequencing technique
|
|
US5367066A
(en)
*
|
1984-10-16 |
1994-11-22 |
Chiron Corporation |
Oligonucleotides with selectably cleavable and/or abasic sites
|
|
JPS61112093A
(ja)
*
|
1984-11-05 |
1986-05-30 |
Wakunaga Seiyaku Kk |
ヌクレオチド誘導体
|
|
FR2575751B1
(fr)
*
|
1985-01-08 |
1987-04-03 |
Pasteur Institut |
Nouveaux nucleosides de derives de l'adenosine, leur preparation et leurs applications biologiques
|
|
DE3507881A1
(de)
*
|
1985-03-06 |
1986-09-11 |
Hoechst Ag, 6230 Frankfurt |
Verfahren und mittel zur phosphorylierung
|
|
US5332845A
(en)
*
|
1985-03-28 |
1994-07-26 |
Chiron Corporation |
Phosphorylating reagents
|
|
US5252760A
(en)
*
|
1985-03-28 |
1993-10-12 |
Chiron Corporation |
Method of using colored phosphorylating reagents
|
|
WO1986006726A1
(en)
*
|
1985-05-15 |
1986-11-20 |
Integrated Genetics, Inc. |
Cytidine analogs
|
|
US4797355A
(en)
*
|
1985-06-13 |
1989-01-10 |
Amgen Inc. |
Methods for attaching polynucleotides to supports
|
|
US4751177A
(en)
*
|
1985-06-13 |
1988-06-14 |
Amgen |
Methods and kits for performing nucleic acid hybridization assays
|
|
US4739044A
(en)
*
|
1985-06-13 |
1988-04-19 |
Amgen |
Method for derivitization of polynucleotides
|
|
WO1986007362A1
(en)
*
|
1985-06-14 |
1986-12-18 |
University Patents, Inc. |
Method for synthesizing deoxyoligonucleotides
|
|
US4757141A
(en)
*
|
1985-08-26 |
1988-07-12 |
Applied Biosystems, Incorporated |
Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof
|
|
EP0216357A3
(en)
*
|
1985-09-25 |
1988-08-31 |
Nippon Zeon Co., Ltd. |
Phosphoramidite compounds and process for production thereof
|
|
US4808708A
(en)
*
|
1985-11-02 |
1989-02-28 |
Toagosei Chemical Industry Co., Ltd. |
Phosphorsulfide derivatives of deoxynucleosides or deoxynucleotides and their uses
|
|
US4855225A
(en)
*
|
1986-02-07 |
1989-08-08 |
Applied Biosystems, Inc. |
Method of detecting electrophoretically separated oligonucleotides
|
|
US5242823A
(en)
*
|
1986-03-07 |
1993-09-07 |
International Genetic Engineering, Inc. |
Cloning of the 38kd Mycoplasma hyorhinis regression-associated antigen
|
|
EP0260032B1
(en)
*
|
1986-09-08 |
1994-01-26 |
Ajinomoto Co., Inc. |
Compounds for the cleavage at a specific position of RNA, oligomers employed for the formation of said compounds, and starting materials for the synthesis of said oligomers
|
|
US4950745A
(en)
*
|
1986-10-30 |
1990-08-21 |
Daicel Chemical Industries, Ltd. |
Process for synthesis of oligonucleotides and compound for forming polymeric protecting group
|
|
US5071974A
(en)
*
|
1986-10-31 |
1991-12-10 |
Amoco Corporation |
Compositions and methods for the synthesis of oligonucleotides having 5'-phosphorylated termini
|
|
US4923901A
(en)
*
|
1987-09-04 |
1990-05-08 |
Millipore Corporation |
Membranes with bound oligonucleotides and peptides
|
|
US6031091A
(en)
*
|
1987-09-21 |
2000-02-29 |
Gen-Probe Incorporated |
Non-nucleotide linking reagents for nucleotide probes
|
|
US5585481A
(en)
*
|
1987-09-21 |
1996-12-17 |
Gen-Probe Incorporated |
Linking reagents for nucleotide probes
|
|
US4965349A
(en)
*
|
1987-12-24 |
1990-10-23 |
Applied Biosystems, Inc. |
Method of synthesizing oligonucleotides labeled with ammonia-labile groups on solid phase supports
|
|
WO1989009780A1
(en)
*
|
1988-04-15 |
1989-10-19 |
Chemical Industry Institute Of Toxicology |
Site-specific tritium-labeled oligodeoxynucleotides
|
|
US5218103A
(en)
*
|
1988-05-26 |
1993-06-08 |
University Patents, Inc. |
Nucleoside thiophosphoramidites
|
|
US5278302A
(en)
*
|
1988-05-26 |
1994-01-11 |
University Patents, Inc. |
Polynucleotide phosphorodithioates
|
|
US5750666A
(en)
*
|
1988-05-26 |
1998-05-12 |
Competitve Technologies, Inc. |
Polynucleotide phosphorodithioate compounds
|
|
IL90359A0
(en)
*
|
1988-05-26 |
1989-12-15 |
University Patents Inc |
Nucleoside and polynucleotide thiophosphoramidite and phosphorodithioate compounds and their production
|
|
US5602244A
(en)
*
|
1988-05-26 |
1997-02-11 |
Competitive Technologies, Inc. |
Polynucleotide phosphorodithioate compounds
|
|
US5216141A
(en)
*
|
1988-06-06 |
1993-06-01 |
Benner Steven A |
Oligonucleotide analogs containing sulfur linkages
|
|
JPH0291088A
(ja)
*
|
1988-09-29 |
1990-03-30 |
Central Glass Co Ltd |
ホスファイトおよびヌクレオシド‐3’‐ホスファイト誘導体およびこれを用いるオリゴヌクレオチドの合成法
|
|
US5262530A
(en)
|
1988-12-21 |
1993-11-16 |
Applied Biosystems, Inc. |
Automated system for polynucleotide synthesis and purification
|
|
AU5192190A
(en)
*
|
1989-02-24 |
1990-09-26 |
City Of Hope |
Heterologous block oligomers
|
|
WO1990012022A1
(en)
*
|
1989-03-31 |
1990-10-18 |
University Patents, Inc. |
Polynucleotide phosphorodithioates as therapeutic agents for retroviral infections
|
|
US6254861B1
(en)
|
1989-05-23 |
2001-07-03 |
Chandra Choudhury |
Hematopoietic growth factor derived from T lymphocytes
|
|
DE3916871A1
(de)
*
|
1989-05-24 |
1990-11-29 |
Boehringer Mannheim Gmbh |
Modifiziertes phosphoramidit-verfahren zur herstellung von modifizierten nukleinsaeuren
|
|
GR890100349A
(el)
*
|
1989-05-26 |
1994-03-31 |
University Patents Inc |
Ενώσεις νουκλεοσιδίων & πολυνουκλεοτιδίων, θειοφωσφοραμιδίων & φωσφοροδιθειικών εστέρων & μέθοδοι.
|
|
KR920701230A
(ko)
*
|
1989-06-05 |
1992-08-11 |
원본미기재 |
엑소뉴클레아제-내성 올리고뉴클레오티드 및 그 제조방법
|
|
US5256775A
(en)
*
|
1989-06-05 |
1993-10-26 |
Gilead Sciences, Inc. |
Exonuclease-resistant oligonucleotides
|
|
US6300486B1
(en)
|
1989-06-15 |
2001-10-09 |
Isis Pharmaceuticals, Inc. |
Large scale synthesis of oligonucleotides and their associated analogs
|
|
US5204455A
(en)
*
|
1989-06-15 |
1993-04-20 |
Froehler Brian C |
Monomethoxytrityl protected oligonucleotides bound to a solid support
|
|
US5164491A
(en)
*
|
1989-06-15 |
1992-11-17 |
Gilead Sciences |
Large scale synthesis of oligonucleotides and their associated analogs
|
|
US5545522A
(en)
|
1989-09-22 |
1996-08-13 |
Van Gelder; Russell N. |
Process for amplifying a target polynucleotide sequence using a single primer-promoter complex
|
|
US7049102B1
(en)
|
1989-09-22 |
2006-05-23 |
Board Of Trustees Of Leland Stanford University |
Multi-gene expression profile
|
|
US5003097A
(en)
*
|
1989-10-02 |
1991-03-26 |
The United States Of America As Represented By The Department Of Health And Human Services |
Method for the sulfurization of phosphorous groups in compounds
|
|
AU6603690A
(en)
*
|
1989-10-05 |
1991-04-28 |
University Patents Inc. |
Nucleoside and polynucleotide thiophosphoramidite and phosphorodithioate compounds and processes
|
|
US5914396A
(en)
*
|
1990-01-11 |
1999-06-22 |
Isis Pharmaceuticals, Inc. |
2'-O-modified nucleosides and phosphoramidites
|
|
EP0463712A3
(en)
|
1990-06-27 |
1992-04-08 |
University Patents, Inc. |
Polynucleotide phosphorodithioates as therapeutic agents for retroviral infections
|
|
US5316908A
(en)
*
|
1990-07-13 |
1994-05-31 |
Life Technologies, Inc. |
Size markers for electrophoretic analysis of DNA
|
|
JPH06509542A
(ja)
*
|
1990-10-26 |
1994-10-27 |
ジンタ・インコーポレイテッド |
オリゴマーを合成するための改良法
|
|
US6605712B1
(en)
*
|
1990-12-20 |
2003-08-12 |
Arch Development Corporation |
Gene transcription and ionizing radiation: methods and compositions
|
|
US5594121A
(en)
*
|
1991-11-07 |
1997-01-14 |
Gilead Sciences, Inc. |
Enhanced triple-helix and double-helix formation with oligomers containing modified purines
|
|
US5556961A
(en)
*
|
1991-11-15 |
1996-09-17 |
Foote; Robert S. |
Nucleosides with 5'-O-photolabile protecting groups
|
|
US8153602B1
(en)
|
1991-11-19 |
2012-04-10 |
Isis Pharmaceuticals, Inc. |
Composition and methods for the pulmonary delivery of nucleic acids
|
|
TW393513B
(en)
*
|
1991-11-26 |
2000-06-11 |
Isis Pharmaceuticals Inc |
Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
|
|
US6235887B1
(en)
*
|
1991-11-26 |
2001-05-22 |
Isis Pharmaceuticals, Inc. |
Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines
|
|
AU3222793A
(en)
*
|
1991-11-26 |
1993-06-28 |
Gilead Sciences, Inc. |
Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
|
|
AU3250093A
(en)
|
1991-12-12 |
1993-07-19 |
Gilead Sciences, Inc. |
Nuclease stable and binding competent oligomers and methods for their use
|
|
US5644048A
(en)
*
|
1992-01-10 |
1997-07-01 |
Isis Pharmaceuticals, Inc. |
Process for preparing phosphorothioate oligonucleotides
|
|
EP0628051B1
(en)
*
|
1992-02-12 |
2003-07-02 |
Chromagen, Inc. |
Applications of fluorescent n-nucleosides and fluorescent structural analogs of n-nucleosides
|
|
US5652099A
(en)
*
|
1992-02-12 |
1997-07-29 |
Conrad; Michael J. |
Probes comprising fluorescent nucleosides and uses thereof
|
|
US5616700A
(en)
*
|
1992-04-24 |
1997-04-01 |
Beckman Instruments, Inc. |
Processes for synthesizing nucleotides and modified nucleotides using N.sub.
|
|
US5348868A
(en)
*
|
1992-04-24 |
1994-09-20 |
Beckman Instruments, Inc. |
Methods and reagents for cleaving and deprotecting oligonucleotides
|
|
US5428148A
(en)
*
|
1992-04-24 |
1995-06-27 |
Beckman Instruments, Inc. |
N4 - acylated cytidinyl compounds useful in oligonucleotide synthesis
|
|
US5583211A
(en)
*
|
1992-10-29 |
1996-12-10 |
Beckman Instruments, Inc. |
Surface activated organic polymers useful for location - specific attachment of nucleic acids, peptides, proteins and oligosaccharides
|
|
US5955591A
(en)
*
|
1993-05-12 |
1999-09-21 |
Imbach; Jean-Louis |
Phosphotriester oligonucleotides, amidites and method of preparation
|
|
US5428149A
(en)
*
|
1993-06-14 |
1995-06-27 |
Washington State University Research Foundation |
Method for palladium catalyzed carbon-carbon coulping and products
|
|
CA2165821C
(en)
*
|
1993-06-23 |
2002-01-08 |
Albert D. Friesen |
Antisense oligonucleotides and therapeutic use thereof in human immunodeficiency virus infection
|
|
US5623068A
(en)
*
|
1994-03-07 |
1997-04-22 |
Beckman Instruments, Inc. |
Synthesis of DNA using substituted phenylacetyl-protected nucleotides
|
|
US6639061B1
(en)
|
1999-07-07 |
2003-10-28 |
Isis Pharmaceuticals, Inc. |
C3′-methylene hydrogen phosphonate oligomers and related compounds
|
|
US5510476A
(en)
*
|
1994-07-07 |
1996-04-23 |
Isis Pharmaceuticals, Inc. |
Carbocation scavenging during oligonucleotide synthesis
|
|
US5552471A
(en)
*
|
1994-08-17 |
1996-09-03 |
The Perkin-Elmer Corporation |
Solid support reagents for the synthesis of 3'-Nitrogen containing polynucleotides
|
|
US5703223A
(en)
*
|
1994-09-02 |
1997-12-30 |
Thomas Jefferson University |
Solid phase synthesis of oligonucleotides with stereospecific substituted phosphonate linkages by pentavalent grignard coupling
|
|
US6558633B1
(en)
|
1994-09-21 |
2003-05-06 |
Isis Pharmaceuticals, Inc. |
Chemical reaction apparatus and methods
|
|
US5604097A
(en)
|
1994-10-13 |
1997-02-18 |
Spectragen, Inc. |
Methods for sorting polynucleotides using oligonucleotide tags
|
|
USRE43097E1
(en)
|
1994-10-13 |
2012-01-10 |
Illumina, Inc. |
Massively parallel signature sequencing by ligation of encoded adaptors
|
|
US5717085A
(en)
*
|
1994-11-23 |
1998-02-10 |
Terrapin Technologies, Inc. |
Process for preparing codon amidites
|
|
US5908926A
(en)
*
|
1995-03-16 |
1999-06-01 |
Duke University |
5'to 3' nucleic acid synthesis using 3'-photoremovable protecting group
|
|
US5750341A
(en)
|
1995-04-17 |
1998-05-12 |
Lynx Therapeutics, Inc. |
DNA sequencing by parallel oligonucleotide extensions
|
|
US6531589B1
(en)
*
|
1995-06-01 |
2003-03-11 |
Hybridon, Inc. |
Base protecting groups and synthons for oligonucleotide synthesis
|
|
US5614622A
(en)
*
|
1995-06-01 |
1997-03-25 |
Hybridon, Inc. |
5-pentenoyl moiety as a nucleoside-amino protecting group, 4-pentenoyl-protected nucleotide synthons, and related oligonucleotide syntheses
|
|
US6111095A
(en)
*
|
1995-06-07 |
2000-08-29 |
Merck & Co., Inc. |
Capped synthetic RNA, analogs, and aptamers
|
|
PL324000A1
(en)
|
1995-06-07 |
1998-04-27 |
Lynx Therapeutics |
Oligionucleotidic labels for sorting and identofication purpose
|
|
US5856464A
(en)
*
|
1995-06-07 |
1999-01-05 |
Lajolla Pharmaceutical Company |
Selective capping solution phase oligonucleotide synthesis
|
|
US5889136A
(en)
*
|
1995-06-09 |
1999-03-30 |
The Regents Of The University Of Colorado |
Orthoester protecting groups in RNA synthesis
|
|
JP2000500740A
(ja)
|
1995-10-19 |
2000-01-25 |
プロリゴ・エルエルシー |
オリゴヌクレオチドの溶液相合成方法
|
|
US5734041A
(en)
|
1995-10-20 |
1998-03-31 |
Mcgill University |
Preparation of chiral phosphorothioate oligomers
|
|
US6160109A
(en)
*
|
1995-10-20 |
2000-12-12 |
Isis Pharmaceuticals, Inc. |
Preparation of phosphorothioate and boranophosphate oligomers
|
|
US6476216B1
(en)
|
1995-10-20 |
2002-11-05 |
Mcgill University |
Preparation of phosphorothioate oligomers
|
|
US5705621A
(en)
*
|
1995-11-17 |
1998-01-06 |
Isis Pharmaceuticals, Inc. |
Oligomeric phosphite, phosphodiester, Phosphorothioate and phosphorodithioate compounds and intermediates for preparing same
|
|
US20030119724A1
(en)
*
|
1995-11-22 |
2003-06-26 |
Ts`O Paul O.P. |
Ligands to enhance cellular uptake of biomolecules
|
|
US5808035A
(en)
*
|
1995-12-08 |
1998-09-15 |
Usher; David A. |
Protected nucleoside and method for its synthesis
|
|
US5736626A
(en)
|
1996-01-29 |
1998-04-07 |
The Perkin-Elmer Corporation |
Solid support reagents for the direct synthesis of 3'-labeled polynucleotides
|
|
EP0932698A1
(en)
*
|
1996-03-26 |
1999-08-04 |
Lynx Therapeutics, Inc. |
Oligonucleotide treatments and compositions for human melanoma
|
|
US5959100A
(en)
|
1996-03-27 |
1999-09-28 |
Nexstar Pharmaceuticals, Inc. |
Pyrimidine nucleosides as therapeutic and diagnostic agents
|
|
US6020481A
(en)
|
1996-04-01 |
2000-02-01 |
The Perkin-Elmer Corporation |
Asymmetric benzoxanthene dyes
|
|
US5852168A
(en)
*
|
1996-04-30 |
1998-12-22 |
Regents Of The University Of Minesota |
Sulfurization of phosphorus-containing compounds
|
|
US7812149B2
(en)
|
1996-06-06 |
2010-10-12 |
Isis Pharmaceuticals, Inc. |
2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
|
|
US9096636B2
(en)
|
1996-06-06 |
2015-08-04 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
|
US7875733B2
(en)
|
2003-09-18 |
2011-01-25 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising 4′-thionucleosides for use in gene modulation
|
|
US6060240A
(en)
*
|
1996-12-13 |
2000-05-09 |
Arcaris, Inc. |
Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom
|
|
US6172217B1
(en)
|
1996-12-27 |
2001-01-09 |
Isis Pharmaceuticals Inc. |
Method of synthesizing phosphorothioate oligonucleotides
|
|
US6103891A
(en)
*
|
1996-12-27 |
2000-08-15 |
Isis Pharmaceuticals, Inc. |
Method for the synthesis of nucleotide or oligonucleotide phosphoramidites
|
|
US5955600A
(en)
*
|
1996-12-27 |
1999-09-21 |
Isis Pharmaceuticals, Inc. |
Method for the synthesis of nucleotide or oligonucleotide phosphoramidites
|
|
US5902881A
(en)
*
|
1997-03-03 |
1999-05-11 |
Isis Pharmaceuticals, Inc. |
Reagent useful for synthesizing sulfurized oligonucleotide analogs
|
|
US5760209A
(en)
*
|
1997-03-03 |
1998-06-02 |
Isis Pharmaceuticals, Inc. |
Protecting group for synthesizing oligonucleotide analogs
|
|
WO1998040496A1
(en)
|
1997-03-12 |
1998-09-17 |
The Perkin-Elmer Corporation |
Dna polymerases having improved labeled nucleotide incorporation properties
|
|
WO1998044156A1
(en)
|
1997-03-27 |
1998-10-08 |
Life Technologies, Inc. |
Nucleic acid ladders
|
|
ES2357877T3
(es)
|
1997-07-15 |
2011-05-03 |
Life Technologies, Inc. |
Escalas de ácido nucleico.
|
|
US6008379A
(en)
|
1997-10-01 |
1999-12-28 |
The Perkin-Elmer Corporation |
Aromatic-substituted xanthene dyes
|
|
US5936087A
(en)
|
1997-11-25 |
1999-08-10 |
The Perkin-Elmer Corporation |
Dibenzorhodamine dyes
|
|
US6583168B1
(en)
|
1997-11-25 |
2003-06-24 |
Applera Corporation |
Sulfonated diarylrhodamine dyes
|
|
US6441150B1
(en)
|
1997-12-16 |
2002-08-27 |
Isis Pharmaceuticals, Inc. |
Compounds for the Synthesis of Nucleotide or oligonucleotide phosphoramidites
|
|
US7427678B2
(en)
*
|
1998-01-08 |
2008-09-23 |
Sigma-Aldrich Co. |
Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method
|
|
EP1051259B1
(en)
*
|
1998-01-12 |
2006-04-05 |
Massachusetts Institute Of Technology |
Method and apparatus for performing microassays
|
|
US6893877B2
(en)
|
1998-01-12 |
2005-05-17 |
Massachusetts Institute Of Technology |
Methods for screening substances in a microwell array
|
|
US6426185B1
(en)
|
1998-01-16 |
2002-07-30 |
Large Scale Biology Corporation |
Method of compiling a functional gene profile in a plant by transfecting a nucleic acid sequence of a donor plant into a different host plant in an anti-sense orientation
|
|
US20020164585A1
(en)
*
|
1998-01-16 |
2002-11-07 |
Sean Chapman |
Method for enhancing RNA or protein production using non-native 5' untranslated sequences in recombinant viral nucleic acids
|
|
US6303848B1
(en)
|
1998-01-16 |
2001-10-16 |
Large Scale Biology Corporation |
Method for conferring herbicide, pest, or disease resistance in plant hosts
|
|
US20030027173A1
(en)
*
|
1998-01-16 |
2003-02-06 |
Della-Cioppa Guy |
Method of determining the function of nucleotide sequences and the proteins they encode by transfecting the same into a host
|
|
US6080868A
(en)
|
1998-01-23 |
2000-06-27 |
The Perkin-Elmer Corporation |
Nitro-substituted non-fluorescent asymmetric cyanine dye compounds
|
|
US6326479B1
(en)
|
1998-01-27 |
2001-12-04 |
Boston Probes, Inc. |
Synthetic polymers and methods, kits or compositions for modulating the solubility of same
|
|
US6020475A
(en)
*
|
1998-02-10 |
2000-02-01 |
Isis Pharmeuticals, Inc. |
Process for the synthesis of oligomeric compounds
|
|
US7273933B1
(en)
|
1998-02-26 |
2007-09-25 |
Isis Pharmaceuticals, Inc. |
Methods for synthesis of oligonucleotides
|
|
US6111086A
(en)
|
1998-02-27 |
2000-08-29 |
Scaringe; Stephen A. |
Orthoester protecting groups
|
|
US6531590B1
(en)
*
|
1998-04-24 |
2003-03-11 |
Isis Pharmaceuticals, Inc. |
Processes for the synthesis of oligonucleotide compounds
|
|
US6590092B1
(en)
*
|
1998-05-19 |
2003-07-08 |
Nam Q. Ngo |
Process for preparing a “universal support” and the reagents used for generating such support
|
|
US6274725B1
(en)
|
1998-06-02 |
2001-08-14 |
Isis Pharmaceuticals, Inc. |
Activators for oligonucleotide synthesis
|
|
US6919437B1
(en)
|
1998-06-11 |
2005-07-19 |
Isis Pharmaceuticals, Inc. |
Synthetic methods and intermediates for triester oligonucleotides
|
|
US6335439B1
(en)
|
1998-06-11 |
2002-01-01 |
Isis Pharmaceuticals, Inc. |
Method of preparing phosphoramidites
|
|
US6270730B1
(en)
*
|
1998-06-16 |
2001-08-07 |
Northwest Engineering Inc. |
Multi-well rotary synthesizer
|
|
US7087148B1
(en)
|
1998-06-23 |
2006-08-08 |
Clinical Micro Sensors, Inc. |
Binding acceleration techniques for the detection of analytes
|
|
US6326478B1
(en)
|
1998-07-08 |
2001-12-04 |
Isis Pharmaceuticals, Inc. |
Process for the synthesis of oligomeric compounds
|
|
US6867294B1
(en)
|
1998-07-14 |
2005-03-15 |
Isis Pharmaceuticals, Inc. |
Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
|
|
US6242589B1
(en)
|
1998-07-14 |
2001-06-05 |
Isis Pharmaceuticals, Inc. |
Phosphorothioate oligonucleotides having modified internucleoside linkages
|
|
US6124484A
(en)
|
1998-07-17 |
2000-09-26 |
Isis Pharmaceuticals, Inc. |
Recovery of triarylmethyl halide protecting groups cleaved during oligonucleotide synthesis
|
|
US6271042B1
(en)
|
1998-08-26 |
2001-08-07 |
Alpha Innotech Corporation |
Biochip detection system
|
|
US6335437B1
(en)
|
1998-09-07 |
2002-01-01 |
Isis Pharmaceuticals, Inc. |
Methods for the preparation of conjugated oligomers
|
|
US6069243A
(en)
*
|
1998-10-06 |
2000-05-30 |
Isis Pharmaceuticals, Inc. |
Process for oligonucleotide synthesis
|
|
US6667176B1
(en)
|
2000-01-11 |
2003-12-23 |
Geron Corporation |
cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
|
|
US6153411A
(en)
*
|
1998-10-30 |
2000-11-28 |
American Water Works Company, Inc. |
Methods and kits for detection of Cryptosporidium parvum using immunomagnetic separation and amplification
|
|
US6169177B1
(en)
|
1998-11-06 |
2001-01-02 |
Isis Pharmaceuticals, Inc. |
Processes for the synthesis of oligomeric compounds
|
|
WO2000036151A1
(en)
|
1998-12-14 |
2000-06-22 |
Li-Cor, Inc. |
A heterogeneous assay for pyrophosphate detection
|
|
US6380378B1
(en)
|
1998-12-24 |
2002-04-30 |
Toagosei Company, Ltd. |
Nucleotide compound, nucleotide block oligonucleotide, and method for producing them
|
|
US6432642B1
(en)
*
|
1999-01-15 |
2002-08-13 |
Pe Corporation (Ny) |
Binary probe and clamp composition and methods for a target hybridization detection
|
|
US6465628B1
(en)
|
1999-02-04 |
2002-10-15 |
Isis Pharmaceuticals, Inc. |
Process for the synthesis of oligomeric compounds
|
|
US6207819B1
(en)
|
1999-02-12 |
2001-03-27 |
Isis Pharmaceuticals, Inc. |
Compounds, processes and intermediates for synthesis of mixed backbone oligomeric compounds
|
|
US20040082774A1
(en)
*
|
1999-03-16 |
2004-04-29 |
Guzaev Andrei P. |
Novel phosphate and thiophosphate protecting groups
|
|
US6121437A
(en)
*
|
1999-03-16 |
2000-09-19 |
Isis Pharmaceuticals, Inc. |
Phosphate and thiophosphate protecting groups
|
|
US6399765B1
(en)
|
1999-03-17 |
2002-06-04 |
Isis Pharmaceuticals, Inc. |
Methods for removing dimethoxytrityl groups from oligonucleotides
|
|
BR0009164A
(pt)
|
1999-03-19 |
2001-12-26 |
Genencor Int |
Placa de teste de múltiplos furos vazados paraseparação de alto desempenho
|
|
AU2998800A
(en)
|
1999-03-24 |
2000-10-09 |
Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The |
N-acylphosphoramidites and their use in oligonucleotide synthesis
|
|
US20020177135A1
(en)
*
|
1999-07-27 |
2002-11-28 |
Doung Hau H. |
Devices and methods for biochip multiplexing
|
|
US6610842B1
(en)
|
1999-05-06 |
2003-08-26 |
Isis Pharmaceuticals, Inc. |
Processes for the synthesis of oligomers using phosphoramidite compositions
|
|
US6221635B1
(en)
|
1999-05-06 |
2001-04-24 |
The Wistar Institute |
Methods for solid-phase amplification of DNA template (SPADT) using multiarrays
|
|
ATE415409T1
(de)
|
1999-05-24 |
2008-12-15 |
Invitrogen Corp |
Ein verfahren zum entschützen markierter oligonukleotide
|
|
US20070059752A1
(en)
*
|
1999-06-09 |
2007-03-15 |
Biosearch Technologies, Inc. |
Fluorescence energy transfer probes with stabilized conformations
|
|
US6750357B1
(en)
|
1999-06-25 |
2004-06-15 |
Syngen, Inc. |
Rhodamine-based fluorophores useful as labeling reagents
|
|
US7183405B2
(en)
|
1999-06-25 |
2007-02-27 |
Syn Gen, Inc. |
Compositions and methods for labeling oligonucleotides
|
|
US6414135B1
(en)
|
1999-07-07 |
2002-07-02 |
Isis Pharmaceuticals, Inc. |
C3′-methylene hydrogen phosphonate monomers and related compounds
|
|
US6593466B1
(en)
|
1999-07-07 |
2003-07-15 |
Isis Pharmaceuticals, Inc. |
Guanidinium functionalized nucleotides and precursors thereof
|
|
US6306599B1
(en)
|
1999-07-16 |
2001-10-23 |
Agilent Technologies Inc. |
Biopolymer arrays and their fabrication
|
|
US6346423B1
(en)
|
1999-07-16 |
2002-02-12 |
Agilent Technologies, Inc. |
Methods and compositions for producing biopolymeric arrays
|
|
US6147200A
(en)
*
|
1999-08-19 |
2000-11-14 |
Isis Pharmaceuticals, Inc. |
2'-O-acetamido modified monomers and oligomers
|
|
US6114518A
(en)
*
|
1999-09-30 |
2000-09-05 |
Becton, Dickinson And Company |
Synthesis and use of labelled phosphoramidite compositions
|
|
CA2386239A1
(en)
|
1999-10-04 |
2001-04-12 |
University Of Medicine And Dentistry Of New Jersey |
Methods for identifying rna binding compounds
|
|
US6451998B1
(en)
|
1999-10-18 |
2002-09-17 |
Agilent Technologies, Inc. |
Capping and de-capping during oligonucleotide synthesis
|
|
WO2001032935A2
(en)
*
|
1999-11-02 |
2001-05-10 |
Celine Hu |
Molecular microarrays and methods for production and use thereof
|
|
US6361958B1
(en)
|
1999-11-12 |
2002-03-26 |
Motorola, Inc. |
Biochannel assay for hybridization with biomaterial
|
|
US6875619B2
(en)
|
1999-11-12 |
2005-04-05 |
Motorola, Inc. |
Microfluidic devices comprising biochannels
|
|
EP1233976A4
(en)
*
|
1999-11-17 |
2003-06-11 |
Jiuping Ji |
SIMULTANEOUS DETECTION OF HBV, HCV AND HIV IN PLASMA SAMPLES WITH THE AID OF A MULTIPLEX FIXING TEST
|
|
US6716994B1
(en)
*
|
2000-01-04 |
2004-04-06 |
Applera Corporation |
Mobility-Modifying Cyanine Dyes
|
|
US20020151040A1
(en)
|
2000-02-18 |
2002-10-17 |
Matthew O' Keefe |
Apparatus and methods for parallel processing of microvolume liquid reactions
|
|
AU2001238606A1
(en)
|
2000-02-18 |
2001-08-27 |
Board Of Trustees Of The Leland Stanford Junior University |
Apparatus and methods for parallel processing of micro-volume liquid reactions
|
|
US7019129B1
(en)
|
2000-05-09 |
2006-03-28 |
Biosearch Technologies, Inc. |
Dark quenchers for donor-acceptor energy transfer
|
|
AU2001265121A1
(en)
*
|
2000-05-30 |
2001-12-11 |
Applera Corporation |
Methods for detecting target nucleic acids using coupled ligation and amplification
|
|
US6887664B2
(en)
|
2000-06-06 |
2005-05-03 |
Applera Corporation |
Asynchronous primed PCR
|
|
CA2412567A1
(en)
|
2000-06-07 |
2001-12-13 |
Li-Cor, Inc. |
Charge-switch nucleotides
|
|
US6936702B2
(en)
*
|
2000-06-07 |
2005-08-30 |
Li-Cor, Inc. |
Charge-switch nucleotides
|
|
US6869764B2
(en)
|
2000-06-07 |
2005-03-22 |
L--Cor, Inc. |
Nucleic acid sequencing using charge-switch nucleotides
|
|
EP1176151B1
(en)
|
2000-07-28 |
2014-08-20 |
Agilent Technologies, Inc. |
Synthesis of polynucleotides using combined oxidation/deprotection chemistry
|
|
DK1349958T3
(da)
|
2000-09-26 |
2009-09-21 |
Boston Probes Inc |
Prober, probesæt, fremgangsmåder og kits til at opnå påvisning, identifikation og/eller tælling af bakterier
|
|
WO2002030944A2
(en)
*
|
2000-10-11 |
2002-04-18 |
Applera Corporation |
Fluorescent nucleobase conjugates having anionic linkers
|
|
US6693187B1
(en)
*
|
2000-10-17 |
2004-02-17 |
Lievre Cornu Llc |
Phosphinoamidite carboxlates and analogs thereof in the synthesis of oligonucleotides having reduced internucleotide charge
|
|
EP1337542A2
(en)
*
|
2000-11-09 |
2003-08-27 |
Invitrogen Corporation |
Method for removing a universal linker from an oligonucleotide
|
|
CN100406065C
(zh)
|
2000-12-01 |
2008-07-30 |
细胞工厂治疗公司 |
糖基化/半乳糖基化肽、双官能接头和核苷酸单体/多聚体的缀合物以及相关的组合物和使用方法
|
|
US6794141B2
(en)
|
2000-12-22 |
2004-09-21 |
Arcturus Bioscience, Inc. |
Nucleic acid amplification
|
|
US6825338B2
(en)
|
2001-03-30 |
2004-11-30 |
Isis Pharmaceuticals, Inc. |
Labeled oligonucleotides, methods for making same, and compounds useful therefor
|
|
US20040242523A1
(en)
*
|
2003-03-06 |
2004-12-02 |
Ana-Farber Cancer Institue And The Univiersity Of Chicago |
Chemo-inducible cancer gene therapy
|
|
CA2442971C
(en)
*
|
2001-04-06 |
2011-06-07 |
University Of Chicago |
Chemotherapeutic induction of egr-1 promoter activity
|
|
US8034791B2
(en)
|
2001-04-06 |
2011-10-11 |
The University Of Chicago |
Activation of Egr-1 promoter by DNA damaging chemotherapeutics
|
|
EP1377683A4
(en)
*
|
2001-04-11 |
2004-09-08 |
Us Gov Health & Human Serv |
MODIFIED RANDOM SPRAYERS FOR PROBE MARKING
|
|
US20030170675A1
(en)
*
|
2001-04-11 |
2003-09-11 |
The Gov't Of The U.S Of America As Represented By The Secretary Of The Dept. Of Health & Human Serv. |
Methods of manipulating nucleic acids
|
|
CA2381367A1
(en)
|
2001-04-12 |
2002-10-12 |
Hironori Komatsu |
Method for purifying 5'-protected 2'-deoxypurine nucleosides
|
|
US6867050B2
(en)
*
|
2001-05-16 |
2005-03-15 |
Academia Sinica |
Apparatus and methods for chemical synthesis
|
|
US20050009101A1
(en)
*
|
2001-05-17 |
2005-01-13 |
Motorola, Inc. |
Microfluidic devices comprising biochannels
|
|
JP2005505749A
(ja)
|
2001-05-21 |
2005-02-24 |
アクララ バイオサイエンシーズ, インコーポレイテッド |
タンパク質を分析するための方法および組成物
|
|
EP2070939B1
(en)
|
2001-05-25 |
2014-04-02 |
Duke University |
Modulators of pharmacological agents
|
|
EP1800697B1
(de)
|
2001-06-05 |
2010-04-14 |
CureVac GmbH |
Stabilisierte mRNA mit erhöhtem G/C-Gehalt für die Gentherapie
|
|
US7118907B2
(en)
*
|
2001-06-06 |
2006-10-10 |
Li-Cor, Inc. |
Single molecule detection systems and methods
|
|
EP1412749A4
(en)
*
|
2001-06-28 |
2006-12-13 |
Ia Inc |
OPTICAL FIBER SENSOR ARRAY
|
|
US7153954B2
(en)
|
2001-07-12 |
2006-12-26 |
Santaris Pharma A/S |
Method for preparation of LNA phosphoramidites
|
|
EP2053406A3
(en)
*
|
2001-07-16 |
2009-06-24 |
caprotec bioanalytics GmbH |
Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
|
|
US6822088B2
(en)
|
2001-07-17 |
2004-11-23 |
Isis Pharmaceuticals, Inc. |
Synthesis of oligonucleotides on solid support
|
|
US20050042629A1
(en)
|
2002-09-13 |
2005-02-24 |
Applera Corporation |
Thermus scotoductus nucleic acid polymerases
|
|
US7052877B2
(en)
|
2001-11-30 |
2006-05-30 |
Applera Corporation |
Thermus brockianus nucleic acid polymerases
|
|
AU2002353001A1
(en)
*
|
2001-12-03 |
2003-06-17 |
The Government Of The United States Of America, Represented By The Secretary Of The Department Of He |
Thermolabile hydroxyl protecting groups and methods of use
|
|
DE10162480A1
(de)
|
2001-12-19 |
2003-08-07 |
Ingmar Hoerr |
Die Applikation von mRNA für den Einsatz als Therapeutikum gegen Tumorerkrankungen
|
|
US7255874B1
(en)
|
2001-12-21 |
2007-08-14 |
Closure Medical Corporation |
Biocompatible polymers and adhesives: compositions, methods of making and uses related thereto
|
|
GB0200526D0
(en)
*
|
2002-01-11 |
2002-02-27 |
Science And Technology The |
Methods
|
|
AU2003210629A1
(en)
*
|
2002-01-23 |
2003-09-02 |
Proligo, Llc |
Methods for the integrated synthesis and purification of oligonucleotides
|
|
ATE443133T1
(de)
|
2002-02-01 |
2009-10-15 |
Life Technologies Corp |
Oligonukleotidzusammensetzungen mit verbesserter effizienz
|
|
US20060009409A1
(en)
|
2002-02-01 |
2006-01-12 |
Woolf Tod M |
Double-stranded oligonucleotides
|
|
US20030166282A1
(en)
|
2002-02-01 |
2003-09-04 |
David Brown |
High potency siRNAS for reducing the expression of target genes
|
|
DK1502102T3
(da)
*
|
2002-03-11 |
2009-05-04 |
Caprotec Bioanalytics Gmbh |
Forbindelser og fremgangsmåder til analysering af proteomet
|
|
CA2477670A1
(en)
*
|
2002-03-15 |
2003-09-25 |
Arcturus Bioscience, Inc. |
Improved nucleic acid amplification
|
|
US7169916B2
(en)
*
|
2002-04-01 |
2007-01-30 |
Isis Pharmaceuticals, Inc. |
Chloral-free DCA in oligonucleotide synthesis
|
|
ATE423317T1
(de)
|
2002-05-08 |
2009-03-15 |
Panasonic Corp |
Biomolekulares substrat und testvorrichtung
|
|
WO2003102216A2
(en)
*
|
2002-05-31 |
2003-12-11 |
Diversa Corporation |
Multiplexed systems for nucleic acid sequencing
|
|
CN100424091C
(zh)
|
2002-06-05 |
2008-10-08 |
三井化学株式会社 |
保护化2’-脱氧胞苷类的精制法
|
|
US20040248094A1
(en)
*
|
2002-06-12 |
2004-12-09 |
Ford Lance P. |
Methods and compositions relating to labeled RNA molecules that reduce gene expression
|
|
DE10229872A1
(de)
|
2002-07-03 |
2004-01-29 |
Curevac Gmbh |
Immunstimulation durch chemisch modifizierte RNA
|
|
US7504215B2
(en)
|
2002-07-12 |
2009-03-17 |
Affymetrix, Inc. |
Nucleic acid labeling methods
|
|
EP1386925A1
(en)
*
|
2002-07-31 |
2004-02-04 |
Girindus AG |
Method for preparing oligonucleotides
|
|
US8277753B2
(en)
|
2002-08-23 |
2012-10-02 |
Life Technologies Corporation |
Microfluidic transfer pin
|
|
CA2495895A1
(en)
*
|
2002-09-08 |
2004-03-18 |
Applera Corporation |
Methods, compositions and libraries pertaining pna dimer and pna oligomer synthesis
|
|
US20040235005A1
(en)
*
|
2002-10-23 |
2004-11-25 |
Ernest Friedlander |
Methods and composition for detecting targets
|
|
US7030230B2
(en)
|
2002-10-25 |
2006-04-18 |
Isis Pharmaceuticals, Inc. |
Process of purifying phosphoramidites
|
|
US9150606B2
(en)
|
2002-11-05 |
2015-10-06 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
|
|
US9150605B2
(en)
|
2002-11-05 |
2015-10-06 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
|
|
US8604183B2
(en)
|
2002-11-05 |
2013-12-10 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
|
|
JPWO2004052908A1
(ja)
*
|
2002-12-09 |
2006-04-13 |
三井化学株式会社 |
フォスフォロアミダイトの製造方法
|
|
GB0229423D0
(en)
*
|
2002-12-18 |
2003-01-22 |
Avecia Ltd |
Process
|
|
AU2003302264A1
(en)
|
2002-12-20 |
2004-09-09 |
Biotrove, Inc. |
Assay apparatus and method using microfluidic arrays
|
|
US7615629B2
(en)
*
|
2002-12-31 |
2009-11-10 |
Sigma-Aldrich Co. |
Methods and compositions for the tandem synthesis of two or more oligonucleotides on the same solid support
|
|
EP1583972B1
(en)
*
|
2003-01-16 |
2010-11-24 |
caprotec bioanalytics GmbH |
Methods for identifying drug non-target proteins
|
|
US7002006B2
(en)
*
|
2003-02-12 |
2006-02-21 |
Isis Pharmaceuticals, Inc. |
Protection of nucleosides
|
|
JP3936300B2
(ja)
*
|
2003-02-28 |
2007-06-27 |
独立行政法人科学技術振興機構 |
新規なグアノシン誘導体及びその用途
|
|
WO2004087069A2
(en)
|
2003-03-27 |
2004-10-14 |
Ptc Therapeutics, Inc. |
METHODS OF IDENTIFYING COMPOUNDS THAT TARGET tRNA SPLICING ENDONUCLEASE AND USES OF SAID COMPOUNDS AS ANTI-PROLIFERATIVE AGENTS
|
|
EP2363025A1
(en)
|
2003-03-27 |
2011-09-07 |
PTC Therapeutics, Inc. |
Targeting enzymes of the TRNA splicing pathway for identification of anti-fungal and/or anti-proliferative molecules
|
|
US7745116B2
(en)
*
|
2003-04-08 |
2010-06-29 |
Pacific Biosciences Of California, Inc. |
Composition and method for nucleic acid sequencing
|
|
US20070179100A1
(en)
*
|
2003-04-09 |
2007-08-02 |
Muthiah Manoharan |
Protected monomers
|
|
WO2004101582A2
(en)
*
|
2003-05-09 |
2004-11-25 |
Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services |
Thermolabile hydroxyl protecting groups and methods of use
|
|
EP1660512A4
(en)
|
2003-06-02 |
2009-12-23 |
Isis Pharmaceuticals Inc |
SYNTHESIS OF OLIGONUCLEOTIDES USING ALTERNATIVE SOLVENTS
|
|
US20050239089A1
(en)
*
|
2003-06-06 |
2005-10-27 |
Johnson Martin D |
Mobility cassettes
|
|
DE10335833A1
(de)
|
2003-08-05 |
2005-03-03 |
Curevac Gmbh |
Transfektion von Blutzellen mit mRNA zur Immunstimulation und Gentherapie
|
|
WO2005027625A2
(en)
*
|
2003-09-18 |
2005-03-31 |
Mayo Foundation For Medical Education And Research |
Transgenic tieg non-human animals
|
|
WO2005049621A1
(en)
|
2003-11-13 |
2005-06-02 |
Isis Pharmaceuticals, Inc. |
5,6-dihydroxy-isoindole derivatives as linkers for oligomer solid phase synthesis
|
|
CN1914222A
(zh)
|
2003-12-22 |
2007-02-14 |
宾夕法尼亚州大学理事会 |
鉴定rna结合蛋白的方法和组合物
|
|
KR20060103957A
(ko)
*
|
2004-01-15 |
2006-10-04 |
알자 코포레이션 |
치료제 전달용의 리포솜 조성물
|
|
US7691316B2
(en)
*
|
2004-02-12 |
2010-04-06 |
Chemistry & Technology For Genes, Inc. |
Devices and methods for the synthesis of nucleic acids
|
|
US8569474B2
(en)
|
2004-03-09 |
2013-10-29 |
Isis Pharmaceuticals, Inc. |
Double stranded constructs comprising one or more short strands hybridized to a longer strand
|
|
CA2559171A1
(en)
|
2004-03-12 |
2005-09-29 |
Biotrove, Inc. |
Nanoliter array loading
|
|
AU2005238490B2
(en)
|
2004-04-22 |
2010-11-18 |
Tobira Therapeutics, Inc. |
Improved modulators of coagulation factors
|
|
JP4592060B2
(ja)
*
|
2004-04-26 |
2010-12-01 |
キヤノン株式会社 |
Pcr増幅反応装置、ならびに、該装置を利用するpcr増幅反応方法
|
|
IL162276A0
(en)
*
|
2004-06-01 |
2005-11-20 |
Hadasit Med Res Service |
Nucleic acid molecules as heparanase potent inhibitors, compositions and methods of use thereof
|
|
US8394947B2
(en)
|
2004-06-03 |
2013-03-12 |
Isis Pharmaceuticals, Inc. |
Positionally modified siRNA constructs
|
|
US20090048192A1
(en)
*
|
2004-06-03 |
2009-02-19 |
Isis Pharmaceuticals, Inc. |
Double Strand Compositions Comprising Differentially Modified Strands for Use in Gene Modulation
|
|
US12070731B2
(en)
|
2004-08-04 |
2024-08-27 |
Life Technologies Corporation |
Methods and systems for aligning dispensing arrays with microfluidic sample arrays
|
|
US20060105453A1
(en)
|
2004-09-09 |
2006-05-18 |
Brenan Colin J |
Coating process for microfluidic sample arrays
|
|
WO2006023880A2
(en)
|
2004-08-23 |
2006-03-02 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for the characterization of oligonucleotides
|
|
DE102004042546A1
(de)
*
|
2004-09-02 |
2006-03-09 |
Curevac Gmbh |
Kombinationstherapie zur Immunstimulation
|
|
US7884086B2
(en)
|
2004-09-08 |
2011-02-08 |
Isis Pharmaceuticals, Inc. |
Conjugates for use in hepatocyte free uptake assays
|
|
AU2005287078A1
(en)
|
2004-09-16 |
2006-03-30 |
Applied Biosystems, Llc. |
Fluorescent dye compounds, conjugates and uses thereof
|
|
CN101065151B
(zh)
|
2004-09-23 |
2014-12-10 |
健泰科生物技术公司 |
半胱氨酸改造的抗体和偶联物
|
|
US20100111856A1
(en)
|
2004-09-23 |
2010-05-06 |
Herman Gill |
Zirconium-radiolabeled, cysteine engineered antibody conjugates
|
|
US9809824B2
(en)
*
|
2004-12-13 |
2017-11-07 |
The United States Of America, Represented By The Secretary, Department Of Health And Human Services |
CpG oligonucleotide prodrugs, compositions thereof and associated therapeutic methods
|
|
US20060142228A1
(en)
*
|
2004-12-23 |
2006-06-29 |
Ambion, Inc. |
Methods and compositions concerning siRNA's as mediators of RNA interference
|
|
EP1856280A4
(en)
*
|
2005-01-12 |
2009-09-09 |
Applera Corp |
COMPOSITIONS, METHODS AND KITS FOR SELECTIVE AMPLIFICATION OF NUCLEIC ACIDS
|
|
US7608433B2
(en)
|
2005-02-09 |
2009-10-27 |
Idexx Laboratories |
Method of detection of classical swine fever
|
|
US8067175B2
(en)
|
2005-02-11 |
2011-11-29 |
Memorial Sloan-Kettering Cancer Center |
Methods and compositions for detecting a drug resistant EGFR mutant
|
|
DE102005023170A1
(de)
|
2005-05-19 |
2006-11-23 |
Curevac Gmbh |
Optimierte Formulierung für mRNA
|
|
WO2006127009A1
(en)
|
2005-05-26 |
2006-11-30 |
Eragen Biosciences, Inc. |
Reagent for the improved synthesis of isoguanosine-containing oligonucleotides
|
|
JP2009501024A
(ja)
*
|
2005-07-12 |
2009-01-15 |
テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション |
癌の診断及び治療における遺伝的及びエピジェネティックな変化
|
|
US7892795B2
(en)
|
2005-08-02 |
2011-02-22 |
Focus Diagnostics, Inc. |
Methods and compositions for detecting BK virus
|
|
WO2007047408A2
(en)
*
|
2005-10-12 |
2007-04-26 |
Pathologica, Llc. |
Promac signature application
|
|
EP1949152A4
(en)
*
|
2005-11-14 |
2014-02-05 |
Bayer Ip Gmbh |
Planar waveguide detection chips and chambers for performing multiplex pcr assays
|
|
US7579459B2
(en)
*
|
2005-12-12 |
2009-08-25 |
Ngo Nam Q |
Activator bound solid supports for nucleic acid synthesis via the phosphoramidite approach
|
|
US7569686B1
(en)
|
2006-01-27 |
2009-08-04 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for synthesis of bicyclic nucleic acid analogs
|
|
CN102908630B
(zh)
|
2006-01-27 |
2014-11-19 |
Isis制药公司 |
6-修饰的双环核酸类似物
|
|
CA3185510A1
(en)
|
2006-02-13 |
2007-08-23 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention |
Primers and probes for detection and discrimination of types and subtypes of influenza viruses
|
|
WO2007126941A2
(en)
*
|
2006-03-24 |
2007-11-08 |
Archemix Corp. |
Solid support reagents for synthesis
|
|
EP2015758B1
(en)
|
2006-05-05 |
2014-04-02 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating expression apob
|
|
US7666854B2
(en)
|
2006-05-11 |
2010-02-23 |
Isis Pharmaceuticals, Inc. |
Bis-modified bicyclic nucleic acid analogs
|
|
EP2066684B1
(en)
|
2006-05-11 |
2012-07-18 |
Isis Pharmaceuticals, Inc. |
5'-modified bicyclic nucleic acid analogs
|
|
WO2007147110A2
(en)
*
|
2006-06-16 |
2007-12-21 |
Pacific Biosciences Of California, Inc. |
Controlled initiation of primer extension
|
|
CA2657576C
(en)
|
2006-07-14 |
2023-10-31 |
The Regents Of The University Of California |
Cancer biomarkers and methods of use thereof
|
|
JP2010507361A
(ja)
|
2006-07-31 |
2010-03-11 |
キュアバック ゲーエムベーハー |
具体的には免疫刺激剤/アジュバントとしての、一般式(I):GlXmGn、または一般式(II):ClXmCnで表される核酸
|
|
DE102006035618A1
(de)
|
2006-07-31 |
2008-02-07 |
Curevac Gmbh |
Nukleinsäure der Formel (I): GlXmGn, insbesondere als immunstimulierendes Adjuvanz
|
|
US8138330B2
(en)
*
|
2006-09-11 |
2012-03-20 |
Sigma-Aldrich Co. Llc |
Process for the synthesis of oligonucleotides
|
|
DE102007001370A1
(de)
|
2007-01-09 |
2008-07-10 |
Curevac Gmbh |
RNA-kodierte Antikörper
|
|
US7947447B2
(en)
|
2007-01-16 |
2011-05-24 |
Somalogic, Inc. |
Method for generating aptamers with improved off-rates
|
|
HUE028389T2
(en)
*
|
2007-05-10 |
2016-12-28 |
Agilent Technologies Inc |
For the synthesis of thiocarbons protecting groups RNSS
|
|
MX2009012635A
(es)
*
|
2007-05-23 |
2012-09-13 |
Mannkind Corp |
Vectores multicistronicos y metodos para su diseño.
|
|
ES2388590T3
(es)
|
2007-05-30 |
2012-10-16 |
Isis Pharmaceuticals, Inc. |
Análogos de ácidos nucleicos bicíclicos con puente aminometileno N-sustituido.
|
|
WO2008154401A2
(en)
|
2007-06-08 |
2008-12-18 |
Isis Pharmaceuticals, Inc. |
Carbocyclic bicyclic nucleic acid analogs
|
|
CA2691364C
(en)
|
2007-06-19 |
2020-06-16 |
Stratos Genomics, Inc. |
High throughput nucleic acid sequencing by expansion
|
|
WO2009006478A2
(en)
|
2007-07-05 |
2009-01-08 |
Isis Pharmaceuticals, Inc. |
6-disubstituted bicyclic nucleic acid analogs
|
|
US8404830B2
(en)
*
|
2007-07-17 |
2013-03-26 |
Somalogic, Inc. |
Method for generating aptamers with improved off-rates
|
|
KR101654007B1
(ko)
|
2007-08-15 |
2016-09-05 |
아이오니스 파마수티컬즈, 인코포레이티드 |
테트라하이드로피란 핵산 유사체
|
|
WO2009030254A1
(en)
|
2007-09-04 |
2009-03-12 |
Curevac Gmbh |
Complexes of rna and cationic peptides for transfection and for immunostimulation
|
|
EP2195428B1
(en)
|
2007-09-19 |
2013-12-11 |
Applied Biosystems, LLC |
SiRNA SEQUENCE-INDEPENDENT MODIFICATION FORMATS FOR REDUCING OFF-TARGET PHENOTYPIC EFFECTS IN RNAi, AND STABILIZED FORMS THEREOF
|
|
WO2009046738A1
(en)
|
2007-10-09 |
2009-04-16 |
Curevac Gmbh |
Composition for treating lung cancer, particularly of non-small lung cancers (nsclc)
|
|
EP3222290A1
(en)
|
2007-10-09 |
2017-09-27 |
CureVac AG |
Composition for treating prostate cancer (pca)
|
|
US7829735B2
(en)
*
|
2007-10-26 |
2010-11-09 |
Northwestern University |
Universal phosphoramidite for preparation of modified biomolecules and surfaces
|
|
WO2009061894A1
(en)
*
|
2007-11-06 |
2009-05-14 |
Pharmaessentia Corporation |
Novel synthesis of beta-nucleosides
|
|
HRP20150528T2
(hr)
|
2008-01-31 |
2016-03-25 |
Curevac Gmbh |
NUKLEINSKE KISELINE KOJE SADRŽE FORMULU (NuGiXmGnNv)a TE NJIHOVI DERIVATI KAO IMUNOSTIMULACIJSKA SREDSTVA/POMOĆNA SREDSTVA
|
|
US8530640B2
(en)
|
2008-02-07 |
2013-09-10 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexitol nucleic acid analogs
|
|
AU2009213147A1
(en)
|
2008-02-11 |
2009-08-20 |
Rxi Pharmaceuticals Corp. |
Modified RNAi polynucleotides and uses thereof
|
|
US8426378B2
(en)
|
2008-03-21 |
2013-04-23 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising tricyclic nucelosides and methods for their use
|
|
DK2285819T3
(da)
|
2008-04-04 |
2013-12-02 |
Isis Pharmaceuticals Inc |
Oligomere forbindelser omfattende neutralt bundne, terminale bicykliske nukleosider
|
|
AU2009246398A1
(en)
|
2008-05-14 |
2009-11-19 |
Bristol-Myers Squibb Company |
Predictors of patient response to treatment with EGF receptor inhibitors
|
|
WO2010005693A1
(en)
*
|
2008-06-23 |
2010-01-14 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Cyclized ngr peptide compounds, compositions, and methods of their use
|
|
JP5438922B2
(ja)
*
|
2008-06-25 |
2014-03-12 |
日東電工株式会社 |
核酸の製造方法
|
|
US8815818B2
(en)
|
2008-07-18 |
2014-08-26 |
Rxi Pharmaceuticals Corporation |
Phagocytic cell delivery of RNAI
|
|
JP2012502991A
(ja)
|
2008-09-22 |
2012-02-02 |
アールエックスアイ ファーマシューティカルズ コーポレーション |
皮膚適用におけるrna干渉
|
|
US8691971B2
(en)
|
2008-09-23 |
2014-04-08 |
Scott G. Petersen |
Self delivering bio-labile phosphate protected pro-oligos for oligonucleotide based therapeutics and mediating RNA interference
|
|
US8604192B2
(en)
|
2008-09-24 |
2013-12-10 |
Isis Pharmaceuticals, Inc. |
Cyclohexenyl nucleic acids analogs
|
|
US8501805B2
(en)
|
2008-09-24 |
2013-08-06 |
Isis Pharmaceuticals, Inc. |
Substituted alpha-L-bicyclic nucleosides
|
|
WO2010037408A1
(en)
|
2008-09-30 |
2010-04-08 |
Curevac Gmbh |
Composition comprising a complexed (m)rna and a naked mrna for providing or enhancing an immunostimulatory response in a mammal and uses thereof
|
|
DK2379084T3
(en)
|
2008-10-15 |
2018-01-22 |
Ionis Pharmaceuticals Inc |
MODULATION OF FACTOR 11 EXPRESSION
|
|
CA2741294C
(en)
|
2008-10-24 |
2018-04-24 |
Isis Pharmaceuticals, Inc. |
5' and 2' bis-substituted nucleosides and oligomeric compounds prepared therefrom
|
|
WO2010048585A2
(en)
|
2008-10-24 |
2010-04-29 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and methods
|
|
WO2010059226A2
(en)
|
2008-11-19 |
2010-05-27 |
Rxi Pharmaceuticals Corporation |
Inhibition of map4k4 through rnai
|
|
AU2009323766B2
(en)
|
2008-12-02 |
2016-10-06 |
Wave Life Sciences Ltd. |
Method for the synthesis of phosphorus atom modified nucleic acids
|
|
US9493774B2
(en)
|
2009-01-05 |
2016-11-15 |
Rxi Pharmaceuticals Corporation |
Inhibition of PCSK9 through RNAi
|
|
MX2011007693A
(es)
|
2009-01-21 |
2011-09-27 |
Vertex Pharma |
Metodos para amplificar acidos nucleicos del virus de hepatitis c.
|
|
WO2010090762A1
(en)
|
2009-02-04 |
2010-08-12 |
Rxi Pharmaceuticals Corporation |
Rna duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
|
|
US8536320B2
(en)
|
2009-02-06 |
2013-09-17 |
Isis Pharmaceuticals, Inc. |
Tetrahydropyran nucleic acid analogs
|
|
WO2010138926A1
(en)
|
2009-05-29 |
2010-12-02 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention |
Nucleic acids for detection and discrimination of genotypes of chlamydophila psittaci
|
|
SG177564A1
(en)
|
2009-07-06 |
2012-02-28 |
Ontorii Inc |
Novel nucleic acid prodrugs and methods of use thereof
|
|
EP2278334A1
(en)
|
2009-07-22 |
2011-01-26 |
Etablissement Francais du Sang |
A membrane based microarray device for high-throughput multianalyte detection
|
|
EP2462153B1
(en)
|
2009-08-06 |
2015-07-29 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexose nucleic acid analogs
|
|
US20110053829A1
(en)
|
2009-09-03 |
2011-03-03 |
Curevac Gmbh |
Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids
|
|
EP2507381A4
(en)
|
2009-12-04 |
2016-07-20 |
Hoffmann La Roche |
MULTISPECIFIC ANTIBODIES, ANTIBODY ANALOGS, COMPOSITIONS AND METHODS
|
|
WO2011069529A1
(en)
|
2009-12-09 |
2011-06-16 |
Curevac Gmbh |
Mannose-containing solution for lyophilization, transfection and/or injection of nucleic acids
|
|
WO2011069528A1
(en)
|
2009-12-09 |
2011-06-16 |
Curevac Gmbh |
Lyophilization of nucleic acids in lactate-containing solutions
|
|
US8779118B2
(en)
|
2010-01-11 |
2014-07-15 |
Isis Pharmaceuticals, Inc. |
Base modified bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
WO2011094580A2
(en)
|
2010-01-28 |
2011-08-04 |
Alnylam Pharmaceuticals, Inc. |
Chelated copper for use in the preparation of conjugated oligonucleotides
|
|
US10113206B2
(en)
|
2010-02-24 |
2018-10-30 |
Grifols Therapeutics Inc. |
Methods, compositions, and kits for determining human immunodeficiency virus (HIV)
|
|
US9193752B2
(en)
|
2010-03-17 |
2015-11-24 |
Isis Pharmaceuticals, Inc. |
5′-substituted bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
CN106074591B
(zh)
|
2010-03-24 |
2020-01-14 |
菲奥医药公司 |
眼部症候中的rna干扰
|
|
EP2550000A4
(en)
|
2010-03-24 |
2014-03-26 |
Advirna Inc |
RNAI COMPOUNDS OF REDUCED SIZE ADMINISTERING
|
|
EP2550002B1
(en)
|
2010-03-24 |
2019-05-08 |
Phio Pharmaceuticals Corp. |
Rna interference in dermal and fibrotic indications
|
|
SG184089A1
(en)
|
2010-04-12 |
2012-11-29 |
Somalogic Inc |
APTAMERS TO ß-NGF AND THEIR USE IN TREATING ß-NGF MEDIATED DISEASES AND DISORDERS
|
|
US20120003639A1
(en)
|
2010-04-27 |
2012-01-05 |
Prelude, Inc. |
Cancer biomarkers and methods of use thereof
|
|
EP3091027B1
(en)
|
2010-04-28 |
2018-01-17 |
Ionis Pharmaceuticals, Inc. |
5' modified nucleosides and oligomeric compounds prepared therefrom
|
|
WO2011139702A2
(en)
|
2010-04-28 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
Modified nucleosides and oligomeric compounds prepared therefrom
|
|
EP2606057B1
(en)
|
2010-04-28 |
2016-06-15 |
Ionis Pharmaceuticals, Inc. |
Modified 5' diphosphate nucleosides and oligomeric compounds prepared therefrom
|
|
US8957200B2
(en)
|
2010-06-07 |
2015-02-17 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
WO2011156202A1
(en)
|
2010-06-08 |
2011-12-15 |
Isis Pharmaceuticals, Inc. |
Substituted 2 '-amino and 2 '-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
CN119552249A
(zh)
|
2010-06-08 |
2025-03-04 |
基因泰克公司 |
半胱氨酸改造的抗体和偶联物
|
|
EP2449113B8
(en)
|
2010-07-30 |
2015-11-25 |
CureVac AG |
Complexation of nucleic acids with disulfide-crosslinked cationic components for transfection and immunostimulation
|
|
WO2012019168A2
(en)
|
2010-08-06 |
2012-02-09 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
EP2620428B1
(en)
|
2010-09-24 |
2019-05-22 |
Wave Life Sciences Ltd. |
Asymmetric auxiliary group
|
|
ES3005233T3
(en)
|
2010-10-01 |
2025-03-14 |
Modernatx Inc |
Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
|
|
WO2012068405A2
(en)
|
2010-11-17 |
2012-05-24 |
Isis Pharmaceuticals, Inc. |
Modulation of alpha synuclein expression
|
|
CA2822825C
(en)
|
2010-12-27 |
2016-02-09 |
Eli Lilly And Company |
Bovine viral diarrhea virus type 1b vaccine compositions and methods
|
|
AR084358A1
(es)
|
2010-12-27 |
2013-05-08 |
Lilly Co Eli |
Composiciones y metodos para identificar y diferenciar componentes virales de vacunas multivalentes de la “fiebre de embarque” (complejo de enfermedad respiratoria bovina (brdc))
|
|
PH12013501409A1
(en)
|
2010-12-30 |
2019-06-03 |
Dow Agrosciences Llc |
Nucleic acid molecules that confer resistance to coleopteran pests
|
|
AP2013007020A0
(en)
|
2010-12-30 |
2013-07-31 |
Dow Agrosciences Llc |
Nucleic acid molecules that target the vacuolar aptase C subunit and confer resistance to coleopteran pests
|
|
EP2658976A4
(en)
|
2010-12-30 |
2014-10-22 |
Dow Agrosciences Llc |
NUCLEIC ACID MOLECULES THAT TARGET THE SMALL RHO1 PROTEIN BINDING THE GTP AND CONFERENCE RESISTANCE TO HARMFUL COLEOPTERS
|
|
EP3375878A1
(en)
|
2010-12-30 |
2018-09-19 |
Dow AgroSciences LLC |
Nucleic acid molecules that target the vacuolar atphase h subunit and confer resistance to coleopteran pests
|
|
DE12722942T1
(de)
|
2011-03-31 |
2021-09-30 |
Modernatx, Inc. |
Freisetzung und formulierung von manipulierten nukleinsäuren
|
|
WO2013048583A2
(en)
|
2011-05-24 |
2013-04-04 |
Elitech Holding B.V. |
Detection of methicillin-resistant staphylococcus aureus
|
|
WO2012170347A1
(en)
|
2011-06-09 |
2012-12-13 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
MX340053B
(es)
|
2011-06-15 |
2016-06-22 |
Grifols Therapeutics Inc * |
Metodos, composiciones y kits para determinar el virus de la inmunodeficiencia humana (vih).
|
|
US9605019B2
(en)
|
2011-07-19 |
2017-03-28 |
Wave Life Sciences Ltd. |
Methods for the synthesis of functionalized nucleic acids
|
|
EP2736916B1
(en)
|
2011-07-26 |
2019-05-22 |
ELITechGroup, Inc. |
Minor groove binder phosphoramidites and methods of use
|
|
EP2643461B1
(en)
|
2011-09-07 |
2016-06-15 |
Grifols Therapeutics Inc. |
Methods, compositions, and kits for determining hepatitis a virus
|
|
US9464124B2
(en)
|
2011-09-12 |
2016-10-11 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
RU2648950C2
(ru)
|
2011-10-03 |
2018-04-02 |
Модерна Терапьютикс, Инк. |
Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение
|
|
JP2015502365A
(ja)
|
2011-12-12 |
2015-01-22 |
オンコイミューニン,インコーポレイティド |
オリゴヌクレオチドのイン−ビボ送達
|
|
AU2012352180A1
(en)
|
2011-12-16 |
2014-07-31 |
Moderna Therapeutics, Inc. |
Modified nucleoside, nucleotide, and nucleic acid compositions
|
|
WO2013113326A1
(en)
|
2012-01-31 |
2013-08-08 |
Curevac Gmbh |
Pharmaceutical composition comprising a polymeric carrier cargo complex and at least one protein or peptide antigen
|
|
WO2013148147A1
(en)
|
2012-03-26 |
2013-10-03 |
The U.S.A., As Represented By The Secretary Dept. Of Health And Human Services |
Dna methylation analysis for the diagnosis, prognosis and treatment of adrenal neoplasms
|
|
US9572897B2
(en)
|
2012-04-02 |
2017-02-21 |
Modernatx, Inc. |
Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
|
|
US9254311B2
(en)
|
2012-04-02 |
2016-02-09 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of proteins
|
|
US9283287B2
(en)
|
2012-04-02 |
2016-03-15 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of nuclear proteins
|
|
WO2013151663A1
(en)
|
2012-04-02 |
2013-10-10 |
modeRNA Therapeutics |
Modified polynucleotides for the production of membrane proteins
|
|
WO2013154799A1
(en)
|
2012-04-09 |
2013-10-17 |
Isis Pharmaceuticals, Inc. |
Tricyclic nucleosides and oligomeric compounds prepared therefrom
|
|
US9221864B2
(en)
|
2012-04-09 |
2015-12-29 |
Isis Pharmaceuticals, Inc. |
Tricyclic nucleic acid analogs
|
|
ES2683707T3
(es)
|
2012-05-02 |
2018-09-27 |
Ibis Biosciences, Inc. |
Secuenciación de ADN
|
|
WO2013166304A1
(en)
|
2012-05-02 |
2013-11-07 |
Ibis Biosciences, Inc. |
Dna sequencing
|
|
US10458915B2
(en)
|
2012-05-18 |
2019-10-29 |
Pacific Biosciences Of California, Inc. |
Heteroarylcyanine dyes
|
|
WO2013185069A1
(en)
|
2012-06-08 |
2013-12-12 |
Shire Human Genetic Therapies, Inc. |
Pulmonary delivery of mrna to non-lung target cells
|
|
JP6268157B2
(ja)
|
2012-07-13 |
2018-01-24 |
株式会社Wave Life Sciences Japan |
不斉補助基
|
|
SG10201912895PA
(en)
|
2012-07-13 |
2020-02-27 |
Wave Life Sciences Ltd |
Chiral control
|
|
JP6246121B2
(ja)
|
2012-07-13 |
2017-12-13 |
株式会社新日本科学 |
キラル核酸アジュバント
|
|
EP2885312B1
(en)
|
2012-08-15 |
2025-09-03 |
Ionis Pharmaceuticals, Inc. |
Method of preparing oligomeric compounds using modified capping protocols
|
|
CA2880869A1
(en)
|
2012-08-20 |
2014-02-27 |
The Regents Of The University Of California |
Polynucleotides having bioreversible groups
|
|
WO2014030066A2
(en)
|
2012-08-22 |
2014-02-27 |
Bernitz Mats Nilsson |
Methods for identifying nucleic acid sequences
|
|
US10294261B2
(en)
*
|
2012-09-04 |
2019-05-21 |
Kabushiki Kaisha Dnaform |
Compound, nucleic acid, labeling substance, and detection method
|
|
IN2015DN02893A
(cg-RX-API-DMAC7.html)
|
2012-10-04 |
2015-09-11 |
Univ Leland Stanford Junior |
|
|
US9029335B2
(en)
|
2012-10-16 |
2015-05-12 |
Isis Pharmaceuticals, Inc. |
Substituted 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
US20160046997A1
(en)
|
2012-10-18 |
2016-02-18 |
Oslo Universitetssykehus Hf |
Biomarkers for cervical cancer
|
|
US10174373B2
(en)
|
2012-10-18 |
2019-01-08 |
Idexx Laboratories, Inc. |
Nucleic acid amplification controls and kits and methods of use thereof
|
|
HRP20220607T1
(hr)
|
2012-11-26 |
2022-06-24 |
Modernatx, Inc. |
Terminalno modificirana rna
|
|
US9701708B2
(en)
|
2013-01-31 |
2017-07-11 |
Ionis Pharmaceuticals, Inc. |
Method of preparing oligomeric compounds using modified coupling protocols
|
|
JP6399560B2
(ja)
|
2013-03-14 |
2018-10-03 |
トランスレイト バイオ, インコーポレイテッド |
mRNAによってコードされる抗体を送達するための方法及び組成物
|
|
TR201901310T4
(tr)
|
2013-03-14 |
2019-02-21 |
Translate Bio Inc |
Mesajcı RNA'nın saflaştırılması yöntemleri.
|
|
US8980864B2
(en)
|
2013-03-15 |
2015-03-17 |
Moderna Therapeutics, Inc. |
Compositions and methods of altering cholesterol levels
|
|
KR102138781B1
(ko)
|
2013-05-01 |
2020-07-28 |
아이오니스 파마수티컬즈, 인코포레이티드 |
아포지질단백질 c-iii 발현을 조절하는 조성물 및 방법
|
|
EP3004131B1
(en)
|
2013-06-05 |
2020-07-22 |
AM Chemicals Llc |
Phosphoramidite building blocks for sugar-conjugated oligonucleotides
|
|
US9069358B2
(en)
|
2013-06-24 |
2015-06-30 |
Biolytic Lab Performance, Inc. |
System for controlling and optimizing reactions in solid phase synthesis of small molecules
|
|
ES2815099T3
(es)
|
2013-08-05 |
2021-03-29 |
Twist Bioscience Corp |
Genotecas sintetizadas de novo
|
|
PL3035955T3
(pl)
|
2013-08-21 |
2020-03-31 |
Curevac Ag |
Kompozycja i szczepionka do leczenia raka płuca
|
|
CA2915728A1
(en)
|
2013-08-21 |
2015-02-26 |
Thomas Kramps |
Respiratory syncytial virus (rsv) vaccine
|
|
KR20160067219A
(ko)
|
2013-10-03 |
2016-06-13 |
모더나 세라퓨틱스, 인코포레이티드 |
저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드
|
|
US11162096B2
(en)
|
2013-10-14 |
2021-11-02 |
Ionis Pharmaceuticals, Inc |
Methods for modulating expression of C9ORF72 antisense transcript
|
|
WO2015061246A1
(en)
|
2013-10-21 |
2015-04-30 |
Isis Pharmaceuticals, Inc. |
Method for solution phase detritylation of oligomeric compounds
|
|
CN105658800A
(zh)
|
2013-10-22 |
2016-06-08 |
夏尔人类遗传性治疗公司 |
Mrna的cns递送及其用途
|
|
BR112016009014B1
(pt)
|
2013-10-22 |
2024-02-06 |
Translate Bio, Inc |
USO DE COMPOSIÇÃO COMPREENDENDO mRNA PARA DEFICIÊNCIA DE ARGININOSSUCINATO SINTETASE
|
|
CN112618732A
(zh)
|
2013-10-22 |
2021-04-09 |
夏尔人类遗传性治疗公司 |
用于递送信使rna的脂质制剂
|
|
EP3574923A1
(en)
|
2013-10-22 |
2019-12-04 |
Translate Bio, Inc. |
Mrna therapy for phenylketonuria
|
|
CA2925021C
(en)
|
2013-11-01 |
2025-05-06 |
Curevac Ag |
MODIFIED MESSENGER RIBONUCLE ACID (MRNA) WITH REDUCED IMMUNOSTIMULATING PROPERTIES
|
|
US10172916B2
(en)
|
2013-11-15 |
2019-01-08 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods of treating heart failure with agonists of hypocretin receptor 2
|
|
JP7008405B2
(ja)
|
2013-11-21 |
2022-01-25 |
ソマロジック・インコーポレーテッド |
シチジン-5-カルボキサミド修飾ヌクレオチド組成物及びそれに関連する方法
|
|
JP6772062B2
(ja)
|
2013-12-02 |
2020-10-21 |
フィオ ファーマシューティカルズ コーポレーションPhio Pharmaceuticals Corp. |
癌の免疫療法
|
|
BR102014031844A2
(pt)
|
2013-12-20 |
2015-10-06 |
Dow Agrosciences Llc |
ras oposto (rop) e moléculas de ácido nucleico relacionadas que conferem resistência a pragas de coleópteros e hemípteros
|
|
CN106028838A
(zh)
|
2013-12-20 |
2016-10-12 |
美国陶氏益农公司 |
赋予鞘翅目害虫抗性的rnapii-140核酸分子
|
|
JP6584414B2
(ja)
|
2013-12-30 |
2019-10-02 |
キュアバック アーゲー |
人工核酸分子
|
|
AU2014375402B2
(en)
|
2013-12-30 |
2020-10-01 |
CureVac SE |
Artificial nucleic acid molecules
|
|
EP3842537A1
(en)
|
2013-12-30 |
2021-06-30 |
CureVac AG |
Artificial nucleic acid molecules
|
|
JPWO2015108048A1
(ja)
|
2014-01-15 |
2017-03-23 |
株式会社新日本科学 |
抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
|
|
EP3095460A4
(en)
|
2014-01-15 |
2017-08-23 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
|
|
JPWO2015108047A1
(ja)
|
2014-01-15 |
2017-03-23 |
株式会社新日本科学 |
免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
|
|
PT3094728T
(pt)
|
2014-01-16 |
2022-05-19 |
Wave Life Sciences Ltd |
Desenho quiral
|
|
EP3119789B1
(en)
|
2014-03-17 |
2020-04-22 |
Ionis Pharmaceuticals, Inc. |
Bicyclic carbocyclic nucleosides and oligomeric compounds prepared therefrom
|
|
HRP20211397T1
(hr)
|
2014-03-19 |
2021-12-10 |
Ionis Pharmaceuticals, Inc. |
Pripravci za modulaciju ekspresije ataksina 2
|
|
US10006027B2
(en)
|
2014-03-19 |
2018-06-26 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating Ataxin 2 expression
|
|
EP3122878B1
(en)
|
2014-03-24 |
2018-10-24 |
Translate Bio, Inc. |
Mrna therapy for the treatment of ocular diseases
|
|
US10369216B2
(en)
|
2014-04-01 |
2019-08-06 |
Curevac Ag |
Polymeric carrier cargo complex for use as an immunostimulating agent or as an adjuvant
|
|
LT3126499T
(lt)
|
2014-04-01 |
2020-07-27 |
Biogen Ma Inc. |
Kompozicijos, skirtos sod-1 ekspresijos moduliavimui
|
|
US10221416B2
(en)
|
2014-04-24 |
2019-03-05 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising alpha-beta-constrained nucleic acid
|
|
KR102739894B1
(ko)
|
2014-04-25 |
2024-12-05 |
샤이어 휴먼 지네틱 테라피즈 인크. |
메신저 rna 의 정제 방법
|
|
US11279934B2
(en)
|
2014-04-28 |
2022-03-22 |
Phio Pharmaceuticals Corp. |
Methods for treating cancer using nucleic acids targeting MDM2 or MYCN
|
|
EP3137476B1
(en)
|
2014-04-28 |
2019-10-09 |
Ionis Pharmaceuticals, Inc. |
Linkage modified oligomeric compounds
|
|
EP3943500A1
(en)
|
2014-04-30 |
2022-01-26 |
Agilent Technologies, Inc. |
Phosphorous protecting groups and methods of preparation and use thereof
|
|
PT3137596T
(pt)
|
2014-05-01 |
2019-09-27 |
Ionis Pharmaceuticals Inc |
Composições e métodos para modulação da expressão do factor b do complemento
|
|
EP3137115B1
(en)
|
2014-05-01 |
2020-10-14 |
Ionis Pharmaceuticals, Inc. |
Method for synthesis of reactive conjugate clusters
|
|
CA2947756A1
(en)
|
2014-05-07 |
2015-11-12 |
Dow Agrosciences Llc |
Dre4 nucleic acid molecules that confer resistance to coleopteran pests
|
|
US10018617B2
(en)
|
2014-05-16 |
2018-07-10 |
Life Technologies Corporation |
Carbopyronone compounds useful as diagnostic adjuvants
|
|
US10022455B2
(en)
|
2014-05-30 |
2018-07-17 |
Translate Bio, Inc. |
Biodegradable lipids for delivery of nucleic acids
|
|
EP3154996B1
(en)
|
2014-06-10 |
2020-03-11 |
Agilent Technologies, Inc. |
Protecting groups for "z nucleotide" and methods thereof
|
|
CN111588695A
(zh)
|
2014-06-24 |
2020-08-28 |
川斯勒佰尔公司 |
用于递送核酸的立体化学富集组合物
|
|
BR112016030852A2
(pt)
|
2014-07-02 |
2018-01-16 |
Shire Human Genetic Therapies |
encapsulação de rna mensageiro
|
|
US10093967B2
(en)
|
2014-08-12 |
2018-10-09 |
The Regents Of The University Of Michigan |
Detection of nucleic acids
|
|
US10900039B2
(en)
|
2014-09-05 |
2021-01-26 |
Phio Pharmaceuticals Corp. |
Methods for treating aging and skin disorders using nucleic acids targeting Tyr or MMP1
|
|
WO2016040748A1
(en)
|
2014-09-12 |
2016-03-17 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for detection of smn protein in a subject and treatment of a subject
|
|
TW201625688A
(zh)
|
2014-09-12 |
2016-07-16 |
建南德克公司 |
經半胱胺酸改造之抗體及接合物
|
|
BR112017007923B1
(pt)
|
2014-10-17 |
2023-12-12 |
The Penn State Research Foundation |
Método para produzir manipulação genética mediada por reações multiplex com rna em uma célula receptora, construção de ácido nucleico,cassete de expressão, vetor, célula receptora e célula geneticamente modificada
|
|
US11543411B2
(en)
|
2014-12-05 |
2023-01-03 |
Prelude Corporation |
DCIS recurrence and invasive breast cancer
|
|
WO2016090262A1
(en)
|
2014-12-05 |
2016-06-09 |
Shire Human Genetic Therapies, Inc. |
Messenger rna therapy for treatment of articular disease
|
|
US10266903B2
(en)
|
2014-12-12 |
2019-04-23 |
Elitechgroup, Inc. |
Methods and compositions for detecting antibiotic resistant bacteria
|
|
EP3230458B1
(en)
|
2014-12-12 |
2020-02-19 |
CureVac AG |
Artificial nucleic acid molecules for improved protein expression
|
|
EP3230468B1
(en)
|
2014-12-12 |
2020-09-16 |
ELITechGroup, Inc. |
Methods and kits for detecting antibiotic resistant bacteria
|
|
US20160194658A1
(en)
|
2014-12-22 |
2016-07-07 |
Dow Agrosciences Llc |
Nucampholin nucleic acid molecules to control coleopteran insect pests
|
|
CA2966092A1
(en)
|
2014-12-30 |
2016-07-07 |
Curevac Ag |
Artificial nucleic acid molecules
|
|
US9688707B2
(en)
|
2014-12-30 |
2017-06-27 |
Ionis Pharmaceuticals, Inc. |
Bicyclic morpholino compounds and oligomeric compounds prepared therefrom
|
|
US10793855B2
(en)
|
2015-01-06 |
2020-10-06 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of C9ORF72 antisense transcript
|
|
WO2016115490A1
(en)
|
2015-01-16 |
2016-07-21 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulation of dux4
|
|
WO2016126987A1
(en)
|
2015-02-04 |
2016-08-11 |
Twist Bioscience Corporation |
Compositions and methods for synthetic gene assembly
|
|
CA2975852A1
(en)
|
2015-02-04 |
2016-08-11 |
Twist Bioscience Corporation |
Methods and devices for de novo oligonucleic acid assembly
|
|
US10450342B2
(en)
|
2015-02-23 |
2019-10-22 |
Ionis Pharmaceuticals, Inc. |
Method for solution phase detritylation of oligomeric compounds
|
|
US11129844B2
(en)
|
2015-03-03 |
2021-09-28 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating MECP2 expression
|
|
US20160264991A1
(en)
|
2015-03-13 |
2016-09-15 |
Dow Agrosciences Llc |
Rna polymerase i1 nucleic acid molecules to control insect pests
|
|
AU2016233135B2
(en)
|
2015-03-19 |
2021-07-08 |
Translate Bio, Inc. |
mRNA therapy for pompe disease
|
|
WO2016167780A1
(en)
|
2015-04-16 |
2016-10-20 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of c9orf72 antisense transcript
|
|
WO2016172377A1
(en)
|
2015-04-21 |
2016-10-27 |
Twist Bioscience Corporation |
Devices and methods for oligonucleic acid library synthesis
|
|
BR102016012010A2
(pt)
|
2015-05-29 |
2020-03-24 |
Dow Agrosciences Llc |
Molécula de ácido nucleico, de ácido ribonucleico (rna) e de ácido ribonucleico de filamento duplo (dsrna), usos de célula, planta e semente, produto primário, bem como métodos para controlar uma população de pragas coleópteras e/ou hemípteras, para melhorar o rendimento de uma cultura, e para produzir uma célula vegetal transgênica e uma planta transgênica
|
|
GB201511470D0
(en)
|
2015-06-30 |
2015-08-12 |
Cellcall Kft |
HPV detection method
|
|
WO2017007825A1
(en)
|
2015-07-06 |
2017-01-12 |
Rxi Pharmaceuticals Corporation |
Methods for treating neurological disorders using a synergistic small molecule and nucleic acids therapeutic approach
|
|
US11001845B2
(en)
|
2015-07-06 |
2021-05-11 |
Phio Pharmaceuticals Corp. |
Nucleic acid molecules targeting superoxide dismutase 1 (SOD1)
|
|
MA43072A
(fr)
|
2015-07-22 |
2018-05-30 |
Wave Life Sciences Ltd |
Compositions d'oligonucléotides et procédés associés
|
|
EP3331557B1
(en)
|
2015-08-04 |
2021-04-07 |
Duke University |
Genetically encoded intrinsically disordered stealth polymers for delivery and methods of using same
|
|
KR102645398B1
(ko)
|
2015-08-28 |
2024-03-07 |
큐어백 에스이 |
신규 인공 핵산 분자
|
|
EP3350314A4
(en)
|
2015-09-18 |
2019-02-06 |
Twist Bioscience Corporation |
OLIGONUCLEIC ACID VARIANT LIBRARIES VARIANT AND SYNTHESIS THEREOF
|
|
KR102794025B1
(ko)
|
2015-09-22 |
2025-04-09 |
트위스트 바이오사이언스 코포레이션 |
핵산 합성을 위한 가요성 기판
|
|
EP3353303B1
(en)
|
2015-09-25 |
2023-08-02 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating ataxin 3 expression
|
|
US11021707B2
(en)
|
2015-10-19 |
2021-06-01 |
Phio Pharmaceuticals Corp. |
Reduced size self-delivering nucleic acid compounds targeting long non-coding RNA
|
|
US20180312545A1
(en)
|
2015-11-09 |
2018-11-01 |
Curevac Ag |
Optimized nucleic acid molecules
|
|
CN108603307A
(zh)
|
2015-12-01 |
2018-09-28 |
特韦斯特生物科学公司 |
功能化表面及其制备
|
|
WO2017096395A1
(en)
|
2015-12-04 |
2017-06-08 |
Ionis Pharmaceuticals, Inc. |
Methods of treating breast cancer
|
|
US11752213B2
(en)
|
2015-12-21 |
2023-09-12 |
Duke University |
Surfaces having reduced non-specific binding and antigenicity
|
|
CA3006015A1
(en)
|
2015-12-31 |
2017-07-06 |
Ionis Pharmaceuticals, Inc. |
Methods for reducing ataxin-2 expression
|
|
EP3400300A4
(en)
|
2016-01-05 |
2019-08-07 |
Ionis Pharmaceuticals, Inc. |
PROCESS FOR REDUCING LRRK2 EXPRESSION
|
|
US10961271B2
(en)
|
2016-03-16 |
2021-03-30 |
Ionis Pharmaceuticals, Inc. |
Methods of modulating KEAP1
|
|
WO2017161168A1
(en)
|
2016-03-16 |
2017-09-21 |
Ionis Pharmaceuticals, Inc. |
Modulation of dyrk1b expression
|
|
WO2017177169A1
(en)
|
2016-04-08 |
2017-10-12 |
Rana Therapeutics, Inc. |
Multimeric coding nucleic acid and uses thereof
|
|
CN109312402A
(zh)
|
2016-04-11 |
2019-02-05 |
得克萨斯州大学系统董事会 |
用于检测单个t细胞受体亲和力和序列的方法和组合物
|
|
US11467156B2
(en)
|
2016-06-01 |
2022-10-11 |
Duke University |
Nonfouling biosensors
|
|
EP3842530A1
(en)
|
2016-06-13 |
2021-06-30 |
Translate Bio, Inc. |
Messenger rna therapy for the treatment of ornithine transcarbamylase deficiency
|
|
WO2017219017A1
(en)
|
2016-06-17 |
2017-12-21 |
Ionis Pharmaceuticals, Inc. |
Modulation of gys1 expression
|
|
IL291323B2
(en)
|
2016-07-15 |
2023-09-01 |
Am Chemicals Llc |
Solid non-nucleoside supports and phosphoramidite building blocks for oligonucleotide synthesis
|
|
US11046776B2
(en)
|
2016-08-05 |
2021-06-29 |
Genentech, Inc. |
Multivalent and multiepitopic antibodies having agonistic activity and methods of use
|
|
WO2018035380A1
(en)
|
2016-08-17 |
2018-02-22 |
Solstice Biologics, Ltd. |
Polynucleotide constructs
|
|
US10907156B2
(en)
|
2016-08-19 |
2021-02-02 |
Fundación Para La Investigación Biomédica Del Hospital Univ. Ramón Y Cajal |
MiR-127 agents for use in the treatment of renal fibrosis
|
|
CN109996876A
(zh)
|
2016-08-22 |
2019-07-09 |
特韦斯特生物科学公司 |
从头合成的核酸文库
|
|
JP6871364B2
(ja)
|
2016-09-21 |
2021-05-12 |
ツイスト バイオサイエンス コーポレーション |
核酸に基づくデータ保存
|
|
WO2018057847A1
(en)
|
2016-09-23 |
2018-03-29 |
Duke University |
Unstructured non-repetitive polypeptides having lcst behavior
|
|
US11400161B2
(en)
|
2016-10-06 |
2022-08-02 |
Ionis Pharmaceuticals, Inc. |
Method of conjugating oligomeric compounds
|
|
EP3538136A1
(en)
|
2016-11-10 |
2019-09-18 |
Translate Bio, Inc. |
Subcutaneous delivery of messenger rna
|
|
AU2017357758B2
(en)
|
2016-11-10 |
2023-11-16 |
Translate Bio, Inc. |
Improved process of preparing mRNA-loaded lipid nanoparticles
|
|
JOP20190104A1
(ar)
|
2016-11-10 |
2019-05-07 |
Ionis Pharmaceuticals Inc |
مركبات وطرق لتقليل التعبير عن atxn3
|
|
KR20190120160A
(ko)
|
2016-11-10 |
2019-10-23 |
트랜슬레이트 바이오 인코포레이티드 |
Mrna의 전달을 위한 개선된 ice계 지질 나노입자 제형
|
|
WO2018089237A1
(en)
|
2016-11-10 |
2018-05-17 |
Dow Agrosciences Llc |
Cytochrome b (cytb) nucleic acid molecules that control pathogens
|
|
US11033570B2
(en)
|
2016-12-02 |
2021-06-15 |
Cold Spring Harbor Laboratory |
Modulation of Lnc05 expression
|
|
EA201991262A1
(ru)
|
2016-12-16 |
2020-04-07 |
Твист Байосайенс Корпорейшн |
Библиотеки вариантов иммунологического синапса и их синтез
|
|
EP3342780A1
(en)
|
2016-12-30 |
2018-07-04 |
Dow AgroSciences LLC |
Pre-mrna processing factor 8 (prp8) nucleic acid molecules to control insect pests
|
|
US11648200B2
(en)
|
2017-01-12 |
2023-05-16 |
Duke University |
Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly
|
|
CN110892485B
(zh)
|
2017-02-22 |
2024-03-22 |
特韦斯特生物科学公司 |
基于核酸的数据存储
|
|
IL268857B2
(en)
|
2017-02-27 |
2024-09-01 |
Translate Bio Inc |
Methods for purification of messenger rna
|
|
ES2925083T3
(es)
|
2017-02-27 |
2022-10-13 |
Translate Bio Inc |
Métodos de purificación de ARN mensajero
|
|
EP3592728A1
(en)
|
2017-03-07 |
2020-01-15 |
Translate Bio, Inc. |
Polyanionic delivery of nucleic acids
|
|
WO2018165309A1
(en)
|
2017-03-08 |
2018-09-13 |
The Regents Of The University Of Michigan |
Analyte detection
|
|
WO2018165564A1
(en)
|
2017-03-09 |
2018-09-13 |
Ionis Pharmaceuticals, Inc. |
Morpholino modified oligomeric compounds
|
|
US10894959B2
(en)
|
2017-03-15 |
2021-01-19 |
Twist Bioscience Corporation |
Variant libraries of the immunological synapse and synthesis thereof
|
|
US11554097B2
(en)
|
2017-05-15 |
2023-01-17 |
Duke University |
Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents
|
|
CA3063531A1
(en)
|
2017-05-16 |
2018-11-22 |
Translate Bio, Inc. |
Treatment of cystic fibrosis by delivery of codon-optimized mrna encoding cftr
|
|
AU2018284227B2
(en)
|
2017-06-12 |
2024-05-02 |
Twist Bioscience Corporation |
Methods for seamless nucleic acid assembly
|
|
WO2018231864A1
(en)
|
2017-06-12 |
2018-12-20 |
Twist Bioscience Corporation |
Methods for seamless nucleic acid assembly
|
|
MA49393A
(fr)
|
2017-06-12 |
2020-04-22 |
Translate Bio Inc |
Poly(phosphoesters) destinés à l'administration d'acides nucléiques
|
|
EP3641834B1
(en)
|
2017-06-19 |
2023-10-04 |
Translate Bio, Inc. |
Messenger rna therapy for the treatment of friedreich's ataxia
|
|
US11597744B2
(en)
|
2017-06-30 |
2023-03-07 |
Sirius Therapeutics, Inc. |
Chiral phosphoramidite auxiliaries and methods of their use
|
|
WO2019006374A1
(en)
|
2017-06-30 |
2019-01-03 |
Duke University |
ORDER AND DISORDER AS A DESIGN PRINCIPLE FOR STIMULI-SENSITIVE BIOPOLYMER NETWORKS
|
|
WO2019036613A1
(en)
|
2017-08-18 |
2019-02-21 |
Ionis Pharmaceuticals, Inc. |
MODULATION OF THE NOTCH SIGNALING PATHWAY FOR THE TREATMENT OF RESPIRATORY DISORDERS
|
|
US10517889B2
(en)
|
2017-09-08 |
2019-12-31 |
Ionis Pharmaceuticals, Inc. |
Modulators of SMAD7 expression
|
|
JP2020536504A
(ja)
|
2017-09-11 |
2020-12-17 |
ツイスト バイオサイエンス コーポレーション |
Gpcr結合タンパク質およびその合成
|
|
CA3075532A1
(en)
|
2017-09-15 |
2019-03-21 |
The Board Of Trustees Of The Leland Stanford Junior University |
Multiplex production and barcoding of genetically engineered cells
|
|
CN111565834B
(zh)
|
2017-10-20 |
2022-08-26 |
特韦斯特生物科学公司 |
用于多核苷酸合成的加热的纳米孔
|
|
TWI809004B
(zh)
|
2017-11-09 |
2023-07-21 |
美商Ionis製藥公司 |
用於降低snca表現之化合物及方法
|
|
MA51306A
(fr)
|
2017-12-20 |
2020-10-28 |
Translate Bio Inc |
Compositions et procédés améliorés pour le traitement du déficit en ornithine transcarbamylase
|
|
WO2019126641A2
(en)
|
2017-12-21 |
2019-06-27 |
Ionis Pharmaceuticals, Inc. |
Modulation of frataxin expression
|
|
KR102804057B1
(ko)
|
2018-01-04 |
2025-05-07 |
트위스트 바이오사이언스 코포레이션 |
Dna 기반 디지털 정보 저장
|
|
JP2021511072A
(ja)
|
2018-01-15 |
2021-05-06 |
アイオニス・ファーマシューティカルズ・インコーポレイテッドIonis Pharmaceuticals,Inc. |
Dnm2発現のモジュレーター
|
|
WO2019147954A1
(en)
|
2018-01-26 |
2019-08-01 |
Duke University |
Albumin binding peptide-drug (aibiped) conjugates and methods of making and using same
|
|
EP3746496A1
(en)
|
2018-02-02 |
2020-12-09 |
Translate Bio, Inc. |
Cationic polymers
|
|
TWI840345B
(zh)
|
2018-03-02 |
2024-05-01 |
美商Ionis製藥公司 |
Irf4表現之調節劑
|
|
EP3759127A4
(en)
|
2018-03-02 |
2022-03-30 |
Ionis Pharmaceuticals, Inc. |
COMPOUNDS AND METHODS FOR MODULATING AMYLOID BETA PRECURSOR PROTEIN
|
|
US11661601B2
(en)
|
2018-03-22 |
2023-05-30 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating FMR1 expression
|
|
AU2019252667A1
(en)
|
2018-04-11 |
2020-10-01 |
Ionis Pharmaceuticals, Inc. |
Modulators of EZH2 expression
|
|
AU2019252812A1
(en)
|
2018-04-13 |
2020-10-01 |
Bristol-Myers Squibb Company |
Novel phosphorous (V)-based reagents, processes for the preparation thereof, and their use in making stereo-defined organophoshorous (V) compounds
|
|
EP3788343B1
(en)
|
2018-04-30 |
2024-03-27 |
Duke University |
Stimuli-responsive peg-like polymer-based drug delivery platform
|
|
US11866788B2
(en)
|
2018-05-08 |
2024-01-09 |
Sanford Burnham Prebys Medical Discovery Institute |
Role of PVT1 in the diagnosis and treatment of MYC-driven cancer
|
|
TW202003541A
(zh)
|
2018-05-09 |
2020-01-16 |
美商Ionis製藥公司 |
用於減少atxn3表現之化合物及方法
|
|
CR20200605A
(es)
|
2018-05-09 |
2021-01-29 |
Ionis Pharmaceuticals Inc |
Compuestos y métodos para la reducción de la expresión de fxi
|
|
WO2019222277A1
(en)
|
2018-05-15 |
2019-11-21 |
Translate Bio, Inc. |
Subcutaneous delivery of messenger rna
|
|
CN112384523B
(zh)
|
2018-05-16 |
2025-03-14 |
川斯勒佰尔公司 |
核糖阳离子脂质
|
|
EP3814497A4
(en)
|
2018-05-18 |
2022-03-02 |
Twist Bioscience Corporation |
POLYNUCLEOTIDES, REAGENTS AND METHODS FOR NUCLEIC ACID HYBRIDIZATION
|
|
US12076439B2
(en)
|
2018-05-24 |
2024-09-03 |
Translate Bio, Inc. |
Thioester cationic lipids
|
|
AU2019277361B2
(en)
|
2018-05-30 |
2025-04-24 |
Translate Bio, Inc. |
Messenger RNA vaccines and uses thereof
|
|
CN112424214A
(zh)
|
2018-05-30 |
2021-02-26 |
川斯勒佰尔公司 |
包含甾族部分的阳离子脂质
|
|
JP2021525743A
(ja)
|
2018-05-30 |
2021-09-27 |
トランスレイト バイオ, インコーポレイテッド |
リン酸エステルカチオン性脂質
|
|
MA52766A
(fr)
|
2018-05-30 |
2021-04-14 |
Translate Bio Inc |
Lipides cationiques vitaminiques
|
|
US11384376B2
(en)
|
2018-05-31 |
2022-07-12 |
Roche Molecular Systems, Inc. |
Reagents and methods for post-synthetic modification of nucleic acids
|
|
US11833168B2
(en)
|
2018-06-14 |
2023-12-05 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for increasing STMN2 expression
|
|
TWI833770B
(zh)
|
2018-06-27 |
2024-03-01 |
美商Ionis製藥公司 |
用於減少 lrrk2 表現之化合物及方法
|
|
WO2020001793A1
(en)
|
2018-06-29 |
2020-01-02 |
Eberhard-Karls-Universität Tübingen |
Artificial nucleic acids for rna editing
|
|
EP3823725A4
(en)
|
2018-07-17 |
2023-05-10 |
Aronora, Inc. |
METHODS FOR SAFELY REDUCING THROMBOPOIETIN
|
|
EP3826608A1
(en)
|
2018-07-23 |
2021-06-02 |
Translate Bio, Inc. |
Dry power formulations for messenger rna
|
|
CA3106986A1
(en)
|
2018-07-25 |
2020-01-30 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for reducing atxn2 expression
|
|
EP3829622A4
(en)
|
2018-08-02 |
2022-05-11 |
Duke University |
DOUBLE AGONIST FUSION PROTEINS
|
|
CA3108544A1
(en)
|
2018-08-24 |
2020-02-27 |
Translate Bio, Inc. |
Methods for purification of messenger rna
|
|
US11357726B2
(en)
|
2018-08-29 |
2022-06-14 |
Translate Bio, Inc. |
Process of preparing mRNA-loaded lipid nanoparticles
|
|
WO2020056338A1
(en)
|
2018-09-14 |
2020-03-19 |
Prelude Corporation |
Method of selection for treatment of subjects at risk of invasive breast cancer
|
|
EP3849617A1
(en)
|
2018-09-14 |
2021-07-21 |
Translate Bio, Inc. |
Composition and methods for treatment of methylmalonic acidemia
|
|
WO2020081933A1
(en)
|
2018-10-19 |
2020-04-23 |
Translate Bio, Inc. |
Pumpless encapsulation of messenger rna
|
|
WO2020097509A1
(en)
|
2018-11-08 |
2020-05-14 |
Translate Bio, Inc. |
Methods and compositions for messenger rna purification
|
|
BR112021008974A2
(pt)
|
2018-11-09 |
2021-08-03 |
Translate Bio, Inc. |
lipídios de 2,5-dioxopiperazina com frações éster, tioéster, dissulfeto e anidrido intercaladas
|
|
EP3876914A2
(en)
|
2018-11-09 |
2021-09-15 |
Translate Bio, Inc. |
Messenger rna therapy for treatment of ocular diseases
|
|
WO2020097376A1
(en)
|
2018-11-09 |
2020-05-14 |
Translate Bio, Inc. |
Multi-peg lipid compounds
|
|
EP3876994A2
(en)
|
2018-11-09 |
2021-09-15 |
Translate Bio, Inc. |
Peg lipidoid compounds
|
|
US20220096612A1
(en)
|
2018-11-12 |
2022-03-31 |
Translatebioinc |
Methods for inducing immune tolerance
|
|
TW202028222A
(zh)
|
2018-11-14 |
2020-08-01 |
美商Ionis製藥公司 |
Foxp3表現之調節劑
|
|
AR117094A1
(es)
|
2018-11-15 |
2021-07-07 |
Ionis Pharmaceuticals Inc |
Moduladores de expresión irf5
|
|
CA3120647A1
(en)
|
2018-11-21 |
2020-05-28 |
Translate Bio, Inc. |
Treatment of cystic fibrosis by delivery of nebulized mrna encoding cftr
|
|
AU2019383413A1
(en)
|
2018-11-21 |
2021-05-27 |
Translate Bio, Inc. |
Cationic lipid compounds and compositions thereof for use in the delivery of messenger RNA
|
|
JP7455831B2
(ja)
|
2018-11-21 |
2024-03-26 |
アイオーニス ファーマシューティカルズ, インコーポレーテッド |
プリオン発現を低減するための化合物及び方法
|
|
CA3124980A1
(en)
|
2018-12-26 |
2020-07-02 |
Twist Bioscience Corporation |
Highly accurate de novo polynucleotide synthesis
|
|
AU2020206109B2
(en)
|
2019-01-07 |
2024-12-19 |
Translate Bio, Inc. |
Composition and methods for treatment of primary ciliary dyskinesia
|
|
WO2020160453A1
(en)
|
2019-01-31 |
2020-08-06 |
Ionis Pharmaceuticals, Inc. |
Modulators of yap1 expression
|
|
CA3131689A1
(en)
|
2019-02-26 |
2020-09-03 |
Twist Bioscience Corporation |
Variant nucleic acid libraries for glp1 receptor
|
|
AU2020227802A1
(en)
|
2019-02-26 |
2021-10-14 |
Twist Bioscience Corporation |
Variant nucleic acid libraries for antibody optimization
|
|
JP7492526B2
(ja)
|
2019-02-27 |
2024-05-29 |
アイオーニス ファーマシューティカルズ, インコーポレーテッド |
Malat1発現のモジュレーター
|
|
UA128437C2
(uk)
|
2019-03-29 |
2024-07-10 |
Айоніс Фармасьютикалз, Інк. |
Сполуки і способи модулювання ube3a-ats
|
|
US20220177423A1
(en)
|
2019-04-18 |
2022-06-09 |
Translate Bio, Inc. |
Cystine cationic lipids
|
|
ES2972014T3
(es)
|
2019-04-22 |
2024-06-10 |
Translate Bio Inc |
Lípidos catiónicos de tioéster
|
|
WO2020227085A1
(en)
|
2019-05-03 |
2020-11-12 |
Translate Bio, Inc. |
Di-thioester cationic lipids
|
|
KR20220024022A
(ko)
|
2019-05-14 |
2022-03-03 |
트랜슬레이트 바이오 인코포레이티드 |
Mrna-로딩된 지질 나노입자를 제조하는 개선된 방법
|
|
US11453877B2
(en)
|
2019-05-15 |
2022-09-27 |
Translate Bio, Inc. |
Methods for purification of messenger RNA
|
|
US20220226244A1
(en)
|
2019-05-31 |
2022-07-21 |
Translate Bio, Inc. |
Macrocyclic lipids
|
|
WO2020257612A1
(en)
|
2019-06-21 |
2020-12-24 |
Twist Bioscience Corporation |
Barcode-based nucleic acid sequence assembly
|
|
JP7724161B2
(ja)
|
2019-06-21 |
2025-08-15 |
トランスレイト バイオ, インコーポレイテッド |
トリシンおよびクエン酸脂質
|
|
WO2020257611A1
(en)
|
2019-06-21 |
2020-12-24 |
Translate Bio, Inc. |
Cationic lipids comprising an hydroxy moiety
|
|
KR20220078557A
(ko)
|
2019-07-08 |
2022-06-10 |
트랜슬레이트 바이오 인코포레이티드 |
개선된 mrna 로딩된 지질 나노입자 및 이의 제조 방법
|
|
US11512314B2
(en)
|
2019-07-12 |
2022-11-29 |
Duke University |
Amphiphilic polynucleotides
|
|
US12144871B2
(en)
|
2019-07-23 |
2024-11-19 |
Translate Bio, Inc. |
Stable compositions of MRNA-loaded lipid nanoparticles and processes of making
|
|
WO2021021673A1
(en)
|
2019-07-26 |
2021-02-04 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating gfap
|
|
US20220323542A1
(en)
|
2019-07-30 |
2022-10-13 |
Translate Bio, Inc. |
TREATMENT OF CYSTIC FIBROSIS BY DELIVERY OF NEBULIZED mRNA ENCODING CFTR
|
|
WO2021030778A1
(en)
|
2019-08-15 |
2021-02-18 |
Ionis Pharmaceuticals, Inc. |
Linkage modified oligomeric compounds and uses thereof
|
|
EP4034566A4
(en)
|
2019-09-23 |
2024-01-24 |
Twist Bioscience Corporation |
VARIANT NUCLEIC ACID BANKS FOR CRTH2
|
|
EP4034564A4
(en)
|
2019-09-23 |
2023-12-13 |
Twist Bioscience Corporation |
VARIANT NUCLEIC ACID LIBRARIES FOR SINGLE-DOMAIN ANTIBODIES
|
|
US20230051811A1
(en)
|
2019-12-20 |
2023-02-16 |
Translate Bio, Inc |
Rectal delivery of messenger rna
|
|
US12053551B2
(en)
|
2019-12-20 |
2024-08-06 |
Translate Bio, Inc. |
Process of preparing mRNA-loaded lipid nanoparticles
|
|
WO2021142245A1
(en)
|
2020-01-10 |
2021-07-15 |
Translate Bio, Inc. |
Compounds, pharmaceutical compositions and methods for modulating expression of muc5b in lung cells and tissues
|
|
US20210324369A1
(en)
|
2020-02-10 |
2021-10-21 |
Translate Bio, Inc. |
Methods and compositions for messenger rna purification
|
|
JP7744354B2
(ja)
|
2020-02-25 |
2025-09-25 |
トランスレイト バイオ, インコーポレイテッド |
Mrna担持脂質ナノ粒子を調製する改善された方法
|
|
AU2021225957A1
(en)
|
2020-02-28 |
2022-09-08 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating SMN2
|
|
EP4126813A1
(en)
|
2020-04-01 |
2023-02-08 |
Translate Bio, Inc. |
Phenolic acid lipid based cationic lipids
|
|
AU2021246530A1
(en)
|
2020-04-02 |
2022-11-03 |
Mirecule, Inc. |
Targeted inhibition using engineered oligonucleotides
|
|
WO2021222768A2
(en)
|
2020-05-01 |
2021-11-04 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating atxn1
|
|
US20230190954A1
(en)
|
2020-05-07 |
2023-06-22 |
Translate Bio, Inc. |
Composition and methods for treatment of primary ciliary dyskinesia
|
|
US20230226219A1
(en)
|
2020-05-14 |
2023-07-20 |
Translate Bio, Inc. |
Peg lipidoid compounds
|
|
CA3183399A1
(en)
|
2020-05-15 |
2021-11-18 |
Translate Bio, Inc. |
Lipid nanoparticle formulations for mrna delivery
|
|
CA3178965A1
(en)
|
2020-05-15 |
2021-11-18 |
Christian COBAUGH |
Messenger rna encoding cas9 for use in genome-editing systems
|
|
AU2021299290A1
(en)
|
2020-06-29 |
2023-01-05 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating PLP1
|
|
US20240307556A1
(en)
|
2020-07-02 |
2024-09-19 |
Maritime Therapeutics, Inc. |
Compositions and methods for reverse gene therapy
|
|
KR20230043914A
(ko)
|
2020-07-28 |
2023-03-31 |
아이오니스 파마수티컬즈, 인코포레이티드 |
App 발현을 감소시키기 위한 화합물 및 방법
|
|
WO2022032060A2
(en)
|
2020-08-07 |
2022-02-10 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating scn2a
|
|
EP4217340A1
(en)
|
2020-09-23 |
2023-08-02 |
Translate Bio, Inc. |
Tes-based cationic lipids
|
|
MX2023003344A
(es)
|
2020-09-23 |
2023-06-05 |
Translate Bio Inc |
Lipidos cationicos a base de piperazina.
|
|
WO2022072836A2
(en)
|
2020-10-01 |
2022-04-07 |
Translate Bio, Inc. |
Methods for purification of messenger rna
|
|
KR20230083323A
(ko)
|
2020-10-06 |
2023-06-09 |
트랜슬레이트 바이오 인코포레이티드 |
개선된 지질 나노입자 공정 및 제형화
|
|
IL301973A
(en)
|
2020-10-12 |
2023-06-01 |
Translate Bio Inc |
Improved process of preparing mrna-loaded lipid nanoparticles
|
|
WO2022081548A1
(en)
|
2020-10-12 |
2022-04-21 |
Translate Bio, Inc. |
Improved process of preparing ice-based lipid nanoparticles
|
|
WO2022078569A1
(en)
|
2020-10-12 |
2022-04-21 |
Eberhard Karls Universität Tübingen |
Artificial nucleic acids for rna editing
|
|
WO2022099003A1
(en)
|
2020-11-06 |
2022-05-12 |
Sanofi |
Lipid nanoparticles for delivering mrna vaccines
|
|
LT4136092T
(lt)
|
2020-11-18 |
2024-09-25 |
Ionis Pharmaceuticals, Inc. |
Junginiai ir būdai, skirti angiotenzinogeno raiškos moduliavimui
|
|
AR124408A1
(es)
|
2020-12-18 |
2023-03-22 |
Ionis Pharmaceuticals Inc |
Compuestos y métodos para modular el factor xii
|
|
WO2022178438A1
(en)
|
2021-02-22 |
2022-08-25 |
Duke University |
Non-immunogenic poegma-aptamer conjugates
|
|
EP4288519A4
(en)
|
2021-02-26 |
2025-03-26 |
The Regents of University of California |
Assembled three-dimensional cultures of human neurons and glia and their use
|
|
TW202309002A
(zh)
|
2021-04-15 |
2023-03-01 |
美商轉譯生技公司 |
基於「古德」緩衝液的陽離子脂質
|
|
US20220364078A1
(en)
|
2021-05-14 |
2022-11-17 |
Crispr Therapeutics Ag |
Mrna large scale synthesis and purification
|
|
CN117480008A
(zh)
|
2021-05-31 |
2024-01-30 |
金斯瑞美国有限公司 |
用于dna合成的电接枝膜
|
|
WO2022261075A1
(en)
|
2021-06-07 |
2022-12-15 |
The Board Of Trustees Of The University Of Illinois |
Photoactivatable gasdermin proteins
|
|
KR20240022610A
(ko)
|
2021-06-18 |
2024-02-20 |
사노피 |
다가 인플루엔자 백신
|
|
JP2024523364A
(ja)
|
2021-06-18 |
2024-06-28 |
アイオーニス ファーマシューティカルズ, インコーポレーテッド |
Ifnar1発現を低減するための化合物及び方法
|
|
CN117677698A
(zh)
|
2021-07-14 |
2024-03-08 |
米雷楚来股份有限公司 |
用于神经肌肉障碍的寡核苷酸及其组合物
|
|
JP2024534216A
(ja)
|
2021-09-02 |
2024-09-18 |
サノフイ |
Rnaアフィニティー精製のための組成物および方法
|
|
EP4395933A1
(en)
|
2021-09-03 |
2024-07-10 |
Elegen Corporation |
Multi-way bead-sorting devices, systems, and methods of use thereof using pressure sources
|
|
EP4413149A1
(en)
|
2021-10-05 |
2024-08-14 |
Microsoft Technology Licensing, LLC |
Regulation of dna synthesis by nucleotides linked to protecting groups
|
|
IL311906A
(en)
|
2021-10-05 |
2024-06-01 |
Sanofi Sa |
METHODS FOR FREEZING AND FREEZE-DRYING LIPID NANOPARTICLES (LNPs) AND LNPs OBTAINED WITH THE SAME
|
|
WO2023077107A1
(en)
|
2021-10-29 |
2023-05-04 |
Sana Biotechnology, Inc. |
Methods and reagents for amplifying viral vector nucleic acid products
|
|
CA3236924A1
(en)
|
2021-11-05 |
2023-05-11 |
Sanofi |
Respiratory syncytial virus rna vaccine
|
|
AU2022388747A1
(en)
|
2021-11-10 |
2024-06-20 |
Translate Bio, Inc. |
Composition and methods for treatment of primary ciliary dyskinesia
|
|
MX2024006240A
(es)
|
2021-11-30 |
2024-06-11 |
Sanofi Pasteur Inc |
Vacunas contra el metapneumovirus humano.
|
|
WO2023111262A1
(en)
|
2021-12-17 |
2023-06-22 |
Sanofi |
Lyme disease rna vaccine
|
|
US20250114305A1
(en)
|
2022-01-17 |
2025-04-10 |
Sanofi |
Lipidic compounds, and uses thereof
|
|
CN118922409A
(zh)
|
2022-03-16 |
2024-11-08 |
翻译生物公司 |
非对称的基于哌嗪的阳离子脂质
|
|
WO2023186842A1
(en)
|
2022-03-28 |
2023-10-05 |
F. Hoffmann-La Roche Ag |
Synthesis of isomerically pure polyol-based phosphoramidites
|
|
JP2025512049A
(ja)
|
2022-04-13 |
2025-04-16 |
サノフイ |
「good」緩衝液ベースのカチオン性脂質
|
|
KR20250008765A
(ko)
|
2022-05-06 |
2025-01-15 |
사노피 |
핵산 백신에 대한 신호 서열
|
|
JP2025520538A
(ja)
|
2022-06-17 |
2025-07-03 |
サノフィ パスツール インコーポレイテッド |
環状rna親和性精製のための組成物及び方法
|
|
CN119487130A
(zh)
|
2022-06-28 |
2025-02-18 |
豪夫迈·罗氏有限公司 |
具有大斯托克斯位移的荧光染料
|
|
AU2023316794A1
(en)
|
2022-07-29 |
2025-03-13 |
Sanofi Pasteur Inc. |
Methods for ethanol-free mrna purification
|
|
CA3265295A1
(en)
|
2022-08-22 |
2024-02-29 |
United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
CORONAVIRUS VACCINES
|
|
KR20250075637A
(ko)
|
2022-09-23 |
2025-05-28 |
아이오니스 파마수티컬즈, 인코포레이티드 |
Mecp2 발현을 감소시키기 위한 화합물 및 방법(compounds and methods for reducing mecp2 expression)
|
|
EP4360657A1
(en)
|
2022-10-28 |
2024-05-01 |
Fundación para la Investigación Biomédica del Hospital Universitario Ramón y Cajal |
Mir-326 for the treatment of cancer
|
|
EP4612300A1
(en)
|
2022-11-04 |
2025-09-10 |
Sanofi Pasteur Inc. |
Methods for messenger rna tailing
|
|
WO2024094881A1
(en)
|
2022-11-04 |
2024-05-10 |
Sanofi |
Respiratory syncytial virus rna vaccination
|
|
WO2024099575A1
(en)
|
2022-11-11 |
2024-05-16 |
Eberhard Karls Universität Tübingen |
Artificial nucleic acids for site-directed editing of a target rna
|
|
CN120265279A
(zh)
|
2022-11-21 |
2025-07-04 |
翻译生物公司 |
信使rna的干粉配制品的组合物及其使用方法
|
|
WO2024126847A1
(en)
|
2022-12-15 |
2024-06-20 |
Sanofi |
Mrna recombinant capping enzymes
|
|
KR20250126796A
(ko)
|
2022-12-22 |
2025-08-25 |
사노피 파스퇴르 인크 |
비스-에스테르 및 아미드 양이온성 지질
|
|
EP4623103A1
(en)
|
2023-01-06 |
2025-10-01 |
DNA Script |
Methods for obtaining correctly assembled nucleic acids
|
|
GB202300915D0
(en)
|
2023-01-20 |
2023-03-08 |
Sisaf Ltd |
mRNA COMPOSITIONS
|
|
AR132053A1
(es)
|
2023-03-02 |
2025-05-21 |
Sanofi Pasteur |
Composiciones para su uso en el tratamiento de clamidia
|
|
KR20250169625A
(ko)
|
2023-04-17 |
2025-12-03 |
사노피 파스퇴르 인크 |
재구성 가능한 건조 분말 제형 및 이의 사용 방법
|
|
WO2024228121A1
(en)
|
2023-05-02 |
2024-11-07 |
The University Of Tokyo |
Long interspersed nuclear element r2 for target-specific gene delivery
|
|
TW202500750A
(zh)
|
2023-05-05 |
2025-01-01 |
法商賽諾菲公司 |
用於治療痤瘡的組成物
|
|
CN121057591A
(zh)
|
2023-05-10 |
2025-12-02 |
赛诺菲巴斯德有限公司 |
组合呼吸道mRNA疫苗
|
|
WO2024256457A1
(en)
|
2023-06-12 |
2024-12-19 |
Sanofi |
Tricine and citric acid-based cationic lipids with aromatic head groups
|
|
WO2024256453A1
(en)
|
2023-06-12 |
2024-12-19 |
Sanofi |
Sterol-based cationic lipids with aromatic head groups
|
|
WO2024256458A1
(en)
|
2023-06-12 |
2024-12-19 |
Sanofi |
Tricine and citric acid-based cationic lipids
|
|
TW202515618A
(zh)
|
2023-06-28 |
2025-04-16 |
法商賽諾菲公司 |
用於遞送核酸之輔助脂質
|
|
WO2025003760A1
(en)
|
2023-06-28 |
2025-01-02 |
Sanofi |
Sterol analogs in lipid nanoparticle formulations
|
|
WO2025003759A1
(en)
|
2023-06-28 |
2025-01-02 |
Sanofi |
Dianhydrohexitol based ionizable lipids for nucleic acid delivery
|
|
TW202517779A
(zh)
|
2023-07-19 |
2025-05-01 |
法商賽諾菲公司 |
牙齦卟啉單胞菌抗原性構築體
|
|
WO2025051975A1
(en)
|
2023-09-06 |
2025-03-13 |
Sanofi |
Modified influenza b hemagglutinin polypeptides and nucleic acids and uses thereof
|
|
WO2025061967A1
(en)
|
2023-09-20 |
2025-03-27 |
Sanofi |
"good" buffer-based cationic lipids for nucleic acid delivery
|
|
WO2025085519A1
(en)
|
2023-10-16 |
2025-04-24 |
Typewriter Therapeutics, Inc. |
R2 retrotransposons for gene writing
|
|
WO2025085682A1
(en)
|
2023-10-18 |
2025-04-24 |
Amgen Inc. |
Evaluation of mrna transcript levels using ddpcr for early pool and single-cell clone assessment in cell line development
|
|
EP4553174A1
(en)
|
2023-11-08 |
2025-05-14 |
Consejo Superior De Investigaciones Científicas |
Methods to determine the thymic function by droplet digital pcr system
|
|
WO2025134071A1
(en)
|
2023-12-22 |
2025-06-26 |
Sanofi |
Malic and glutaric acid based ionizable lipids
|
|
WO2025141521A1
(en)
|
2023-12-29 |
2025-07-03 |
Sanofi |
Lipids having dendritic moieties
|
|
WO2025163146A1
(en)
|
2024-01-31 |
2025-08-07 |
Sanofi |
Methods for ethanol-free mrna purification
|
|
WO2025196065A1
(en)
|
2024-03-20 |
2025-09-25 |
Sanofi |
Novel homocysteine based lipids and their use for delivery of nucleic acids
|
|
WO2025210592A1
(en)
|
2024-04-05 |
2025-10-09 |
Sanofi Pasteur Inc. |
Muscle cell lnp-mrna quality control assays
|
|
WO2025217194A1
(en)
|
2024-04-09 |
2025-10-16 |
Typewriter Therapeutics, Inc. |
Repeat dosing of retrotransposons
|
|
WO2025250906A1
(en)
|
2024-05-30 |
2025-12-04 |
Aera Therapeutics, Inc. |
Process for preparation of targeted lipid nanoparticles
|