BE1002982A4 - Derives de 4'-phosphates de glucosides d'epipodophyllotoxine. - Google Patents

Derives de 4'-phosphates de glucosides d'epipodophyllotoxine. Download PDF

Info

Publication number
BE1002982A4
BE1002982A4 BE8800898A BE8800898A BE1002982A4 BE 1002982 A4 BE1002982 A4 BE 1002982A4 BE 8800898 A BE8800898 A BE 8800898A BE 8800898 A BE8800898 A BE 8800898A BE 1002982 A4 BE1002982 A4 BE 1002982A4
Authority
BE
Belgium
Prior art keywords
phosphate derivatives
glucosides
epipodophyllotoxin glucosides
epipodophyllotoxin
phosphate
Prior art date
Application number
BE8800898A
Other languages
English (en)
French (fr)
Inventor
Mark G Saulnier
Peter D Senter
John F Kadow
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of BE1002982A4 publication Critical patent/BE1002982A4/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Cable Accessories (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
BE8800898A 1987-08-04 1988-08-03 Derives de 4'-phosphates de glucosides d'epipodophyllotoxine. BE1002982A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8149387A 1987-08-04 1987-08-04
US07/199,731 US4904768A (en) 1987-08-04 1988-05-27 Epipodophyllotoxin glucoside 4'-phosphate derivatives

Publications (1)

Publication Number Publication Date
BE1002982A4 true BE1002982A4 (fr) 1991-10-15

Family

ID=26765636

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8800898A BE1002982A4 (fr) 1987-08-04 1988-08-03 Derives de 4'-phosphates de glucosides d'epipodophyllotoxine.

Country Status (34)

Country Link
US (3) US4904768A (cg-RX-API-DMAC7.html)
JP (1) JPH0699465B2 (cg-RX-API-DMAC7.html)
KR (1) KR900006230B1 (cg-RX-API-DMAC7.html)
CN (1) CN1027169C (cg-RX-API-DMAC7.html)
AT (1) AT398974B (cg-RX-API-DMAC7.html)
BE (1) BE1002982A4 (cg-RX-API-DMAC7.html)
CA (1) CA1310637C (cg-RX-API-DMAC7.html)
CH (1) CH676716A5 (cg-RX-API-DMAC7.html)
CY (1) CY1625A (cg-RX-API-DMAC7.html)
CZ (1) CZ286893B6 (cg-RX-API-DMAC7.html)
DD (2) DD299067A5 (cg-RX-API-DMAC7.html)
DE (1) DE3826562A1 (cg-RX-API-DMAC7.html)
DK (2) DK169344B1 (cg-RX-API-DMAC7.html)
ES (1) ES2010775A6 (cg-RX-API-DMAC7.html)
FI (1) FI87790C (cg-RX-API-DMAC7.html)
FR (1) FR2622193B1 (cg-RX-API-DMAC7.html)
GB (1) GB2207674B (cg-RX-API-DMAC7.html)
GR (1) GR1000490B (cg-RX-API-DMAC7.html)
HK (1) HK6392A (cg-RX-API-DMAC7.html)
HU (3) HU208147B (cg-RX-API-DMAC7.html)
IE (1) IE61040B1 (cg-RX-API-DMAC7.html)
IL (1) IL87290A (cg-RX-API-DMAC7.html)
IT (1) IT1226825B (cg-RX-API-DMAC7.html)
LU (2) LU87290A1 (cg-RX-API-DMAC7.html)
MX (1) MX173843B (cg-RX-API-DMAC7.html)
MY (1) MY104321A (cg-RX-API-DMAC7.html)
NL (2) NL192683C (cg-RX-API-DMAC7.html)
NO (4) NO170284C (cg-RX-API-DMAC7.html)
NZ (1) NZ225615A (cg-RX-API-DMAC7.html)
PT (1) PT88186B (cg-RX-API-DMAC7.html)
SE (1) SE502214C2 (cg-RX-API-DMAC7.html)
SG (1) SG101291G (cg-RX-API-DMAC7.html)
SK (1) SK541288A3 (cg-RX-API-DMAC7.html)
YU (3) YU143688A (cg-RX-API-DMAC7.html)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5191071A (en) * 1987-08-21 1993-03-02 Novo Nordisk A/S Monoesters of glycosides and a process for enzymatic preparation thereof
US4965348A (en) * 1989-05-19 1990-10-23 Bristol-Myers Company Dimeric epipodophyllotoxin glucoside derivatives
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
US5066645A (en) * 1989-09-01 1991-11-19 Bristol-Myers Company Epipodophyllotoxin altroside derivatives
US6610299B1 (en) 1989-10-19 2003-08-26 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US7241595B2 (en) 1989-10-20 2007-07-10 Sanofi-Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US6475486B1 (en) 1990-10-18 2002-11-05 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US5552154A (en) * 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5034380A (en) * 1989-11-20 1991-07-23 Bristol-Myers Squibb Company Alkoxymethylidene epipodophyllotoxin glucosides
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
US4997931A (en) * 1990-06-11 1991-03-05 Bristol-Myers Squibb Company Epipodophyllotoxin glycosides
TW260671B (cg-RX-API-DMAC7.html) * 1991-04-29 1995-10-21 Bristol Myers Squibb Co
IT1250692B (it) * 1991-07-23 1995-04-21 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
US5648474A (en) * 1991-10-08 1997-07-15 Bristol-Myers Squibb Crystalline etoposide 4'-phosphate diethanolate
CA2085520C (en) * 1991-12-23 1996-07-16 Uday Shankar Gogate Stable hexahydrate of etoposide 4'-phosphate disodium salt
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
JP3061476B2 (ja) * 1992-04-24 2000-07-10 日本化薬株式会社 エトポシド燐酸エステルの製造法
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide
FR2725990B1 (fr) * 1994-10-21 1997-01-10 Pf Medicament Derives hydrosolubles d'epipodophyllotoxine, leur procede de preparation, leur utilisation a titre de medicament, et leur utilisation destinee aux traitements anticancereux
US5942386A (en) * 1995-06-07 1999-08-24 Thomas Jefferson University Anti-fungal agents and methods of identifying and using the same
IL125895A (en) * 1996-04-01 2001-09-13 Epix Medical Inc Use of an image-enhancing moiety in the preparation of a bioactivated nmr or optical imaging contrast agent from a prodrug
US6207673B1 (en) 1997-03-12 2001-03-27 The University Of North Carolina At Chapel Hill Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
WO1999032499A1 (en) * 1997-12-23 1999-07-01 Korea Research Institute Of Chemical Technology 4'-O-DEMETHYL-EPIPODOPHYLLOTOXIN-β-D-GLUCOSIDE ACETAL DERIVATIVES
HK1049787B (en) 1999-10-01 2014-07-25 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
US6506739B1 (en) 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
AP2003002831A0 (en) * 2001-10-26 2003-09-30 Centre Nat Rech Scient Derivatives of etoposide and analogs, and pharmaceutical compositions containing them
NZ574146A (en) 2002-07-15 2010-05-28 Univ Texas Peptides binding to phosphatidylethanolamine and their use in treating viral infections
SI1583562T1 (sl) * 2003-01-06 2011-10-28 Angiochem Inc AngioPep-1, sorodne spojine in njihove uporabe
CN100334090C (zh) * 2005-02-02 2007-08-29 南京医科大学 吡啶类鬼臼毒素化合物及其制备方法和在制备杀虫剂中的应用
US20090016959A1 (en) * 2005-02-18 2009-01-15 Richard Beliveau Delivery of antibodies to the central nervous system
AU2005327497B2 (en) * 2005-02-18 2012-04-12 Angiochem Inc. Aprotinin polypeptides for transporting a compound across the blood-brain barrier
DK2433653T3 (da) * 2005-07-15 2019-08-19 Angiochem Inc Anvendelse af aprotininpolypeptider som bærere i farmaceutiske konjugater
CN100410266C (zh) * 2006-01-11 2008-08-13 重庆华邦制药股份有限公司 鬼臼毒素磷酸酯衍生物的合成方法
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
PE20070978A1 (es) * 2006-02-14 2007-11-15 Novartis Ag COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks)
TW200808739A (en) * 2006-04-06 2008-02-16 Novartis Vaccines & Diagnostic Quinazolines for PDK1 inhibition
GB0625283D0 (en) * 2006-12-19 2007-01-24 Cyclacel Ltd Combination
US9365634B2 (en) * 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
US8263644B2 (en) * 2007-09-13 2012-09-11 Bristol-Myers Squibb Company Cytotoxic xanthone compounds
EP2614837A1 (en) 2007-11-09 2013-07-17 Affitech Research AS Anti-VEGF antibody compositions and methods
KR20100093129A (ko) 2007-12-20 2010-08-24 노파르티스 아게 Ｐｉ ３ 키나제 억제제로서 사용되는 티아졸 유도체
WO2009127072A1 (en) * 2008-04-18 2009-10-22 Angiochem Inc. Pharmaceutical compositions of paclitaxel, paclitaxel analogs or paclitaxel conjugates and related methods of preparation and use
CA2740316A1 (en) 2008-10-15 2010-04-22 Angiochem Inc. Conjugates of glp-1 agonists and uses thereof
CA2740317A1 (en) 2008-10-15 2010-04-22 Angiochem Inc. Etoposide and doxorubicin conjugates for drug delivery
CA2745524C (en) * 2008-12-05 2020-06-09 Angiochem Inc. Conjugates of neurotensin or neurotensin analogs and uses thereof
CN102300987A (zh) 2008-12-17 2011-12-28 安吉奥开米公司 膜型-1基质金属蛋白抑制剂及其用途
ES2729261T3 (es) 2009-04-20 2019-10-31 Angiochem Inc Tratamiento del cáncer de ovario utilizando un agente anticancerígeno conjugado con un análogo de Angiopep-2
US8293753B2 (en) 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
RU2012103240A (ru) 2009-07-02 2013-08-10 Ангиокем Инк. Мультимерные пептидные конъюгаты и их применение
CN102762565A (zh) 2010-02-22 2012-10-31 弗·哈夫曼-拉罗切有限公司 吡啶并[3,2-d]嘧啶PI3δ抑制剂化合物及使用方法
US9586954B2 (en) 2010-06-22 2017-03-07 Demerx, Inc. N-substituted noribogaine prodrugs
AR082418A1 (es) 2010-08-02 2012-12-05 Novartis Ag Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico
ES2611885T3 (es) 2011-01-31 2017-05-11 Novartis Ag Derivados heterocíclicos novedosos
US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
WO2013061305A1 (en) 2011-10-28 2013-05-02 Novartis Ag Novel purine derivatives and their use in the treatment of disease
CA2855994A1 (en) * 2011-12-09 2013-06-13 Demerx, Inc. Phosphate esters of noribogaine
RU2630975C2 (ru) 2012-05-16 2017-09-15 Новартис Аг Режим дозирования pi-3 киназы
US9783535B2 (en) 2012-12-20 2017-10-10 Demerx, Inc. Substituted noribogaine
JP2016539149A (ja) 2013-12-06 2016-12-15 ノバルティス アーゲー アルファ−アイソフォーム選択的ホスファチジルイノシトール３−キナーゼ阻害剤の投薬レジメン
CA2989400A1 (en) 2015-06-15 2016-12-22 Angiochem Inc. Ang1005 for the treatment of leptomeningeal carcinomatosis
MX2018005298A (es) 2015-11-02 2018-06-22 Novartis Ag Regimen de dosificacion para un inhibidor de fosfatidilinositol 3-quinasa.
WO2018060833A1 (en) 2016-09-27 2018-04-05 Novartis Ag Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
KR102378151B1 (ko) 2020-05-11 2022-03-24 주식회사 제이앤씨사이언스 베타-아포피크로포도필린의 신규한 유도체

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1171314A (fr) * 1955-05-13 1959-01-23 Sandoz Ag Produits de condensation de glucosides avec des composés carbonyliques et leur préparation

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6613143A (cg-RX-API-DMAC7.html) * 1965-09-21 1967-03-22
CH464957A (de) * 1965-12-14 1968-11-15 Sandoz Ag Verfahren zur Herstellung eines neuen Glucosids
CH481095A (de) * 1966-12-13 1969-11-15 Sandoz Ag Vefahren zur Herstellung neuer Glucoside
CH514578A (de) * 1968-02-27 1971-10-31 Sandoz Ag Verfahren zur Herstellung von Glucosiden
CH543502A (de) * 1970-11-20 1973-10-31 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
GB1395820A (en) * 1971-06-05 1975-05-29 Villax I Preparation of 21-inorganic esters of corticosteroids and salts thereof
CH589668A5 (en) * 1973-06-07 1977-07-15 Sandoz Ag Cytostatic (4')-demethyl substd. epipodophyllotoxin - prepd. from the corresp. glucopyranoside with (3)-thiophene-carboxaldehyde
FR2397425A1 (fr) * 1977-07-11 1979-02-09 Rhone Poulenc Ind Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent
EP0111058B1 (en) * 1982-11-26 1987-11-04 Nippon Kayaku Kabushiki Kaisha Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
US4567253A (en) * 1984-02-03 1986-01-28 Tony Durst 2-Substituted derivatives of podophyllotoxin and etoposide
JPS60208910A (ja) * 1984-03-31 1985-10-21 Green Cross Corp:The 水難溶性薬物・リン脂質複合体の製造方法
JPS60246393A (ja) * 1984-05-22 1985-12-06 Nippon Kayaku Co Ltd エトポシドの新規製造法
US4739046A (en) * 1985-08-19 1988-04-19 Luzio Nicholas R Di Soluble phosphorylated glucan
IL77334A (en) * 1985-12-16 1991-04-15 Univ Bar Ilan Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor
US4916217A (en) * 1987-01-08 1990-04-10 Bristol-Myers Company Phosphorus containing derivatives of epipodophyllotoxin
JPS63192793A (ja) * 1987-02-06 1988-08-10 Nippon Kayaku Co Ltd ４′−デメチル−エピポドフイロトキシン誘導体の新規エステル
US4874851A (en) * 1987-07-01 1989-10-17 Bristol-Meyers Company 3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1171314A (fr) * 1955-05-13 1959-01-23 Sandoz Ag Produits de condensation de glucosides avec des composés carbonyliques et leur préparation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PROCEEDINGDS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA, vol. 85, no. 13, July 1988, pages 4842-4846; P.D. SENTER et al.: "Anti-tumor effects of antibody-alkaline phosphatase conjugates in combination wth etoposide phosphate" *

Also Published As

Publication number Publication date
FI883596A7 (fi) 1989-02-05
FI87790C (fi) 1993-02-25
GB2207674B (en) 1991-09-11
DD299067A5 (de) 1992-03-26
LU90138I2 (fr) 1997-11-26
AT398974B (de) 1995-02-27
US4904768A (en) 1990-02-27
NO1998002I1 (no) 1998-01-14
SK279325B6 (sk) 1998-10-07
PT88186A (pt) 1989-06-30
FI883596A0 (fi) 1988-08-01
YU10390A (en) 1990-06-30
SE8802815L (sv) 1989-02-05
YU143688A (en) 1990-04-30
NL8801934A (nl) 1989-03-01
CN1027169C (zh) 1994-12-28
MX173843B (es) 1994-03-30
HUT47303A (en) 1989-02-28
US5041424A (en) 1991-08-20
CY1625A (en) 1992-07-10
NO920277L (no) 1989-02-24
USRE35524E (en) 1997-06-03
NO170284C (no) 1992-09-30
HU905862D0 (en) 1991-03-28
AU610619B2 (en) 1991-05-23
NZ225615A (en) 1991-06-25
HU208147B (en) 1993-08-30
IE882378L (en) 1989-02-04
DK11992A (da) 1992-01-31
DD274423A5 (de) 1989-12-20
MX9202851A (es) 1992-06-30
IL87290A0 (en) 1989-01-31
IE61040B1 (en) 1994-09-07
CH676716A5 (cg-RX-API-DMAC7.html) 1991-02-28
ATA195588A (de) 1994-07-15
NO920665L (no) 1989-02-24
HK6392A (en) 1992-01-17
NO883299L (no) 1989-02-24
SE8802815D0 (sv) 1988-08-03
DK434088A (da) 1989-02-05
FR2622193B1 (fr) 1993-12-17
DE3826562C2 (cg-RX-API-DMAC7.html) 1993-04-08
DK434088D0 (da) 1988-08-03
SK541288A3 (en) 1998-10-07
FI87790B (fi) 1992-11-13
LU87290A1 (fr) 1990-02-07
NO920277D0 (no) 1992-01-22
IL87290A (en) 1993-01-31
NL970042I1 (nl) 1998-03-02
CZ541288A3 (cs) 1999-12-15
NO172440B (no) 1993-04-13
NL192683B (cg-RX-API-DMAC7.html) 1997-08-01
IT8821535A0 (it) 1988-07-28
CA1310637C (en) 1992-11-24
AU2030688A (en) 1989-06-08
ES2010775A6 (es) 1989-12-01
KR900006230B1 (ko) 1990-08-27
CZ286893B6 (cs) 2000-07-12
NO172440C (no) 1993-07-21
NO920665D0 (no) 1992-02-20
FR2622193A1 (fr) 1989-04-28
HU202547B (en) 1991-03-28
JPH01100188A (ja) 1989-04-18
PT88186B (pt) 1995-07-03
DE3826562A1 (de) 1989-02-16
GB2207674A (en) 1989-02-08
NO883299D0 (no) 1988-07-26
NL192683C (nl) 1997-12-02
CN1061225A (zh) 1992-05-20
YU10490A (en) 1990-06-30
HU211960A9 (en) 1996-01-29
SE502214C2 (sv) 1995-09-18
DK11992D0 (da) 1992-01-31
KR890003790A (ko) 1989-04-18
MY104321A (en) 1994-03-31
NL970042I2 (cg-RX-API-DMAC7.html) 2005-06-01
DK169344B1 (da) 1994-10-10
NO170284B (no) 1992-06-22
SG101291G (en) 1992-01-17
IT1226825B (it) 1991-02-19
GR880100512A (en) 1989-05-25
JPH0699465B2 (ja) 1994-12-07
GR1000490B (el) 1992-07-30
GB8818462D0 (en) 1988-09-07

Similar Documents

Publication Publication Date Title
BE1002982A4 (fr) Derives de 4'-phosphates de glucosides d'epipodophyllotoxine.
DE69202243D1 (de) 2,4-Diaminochinazolin-Derivate, um die Antitumorwirkung zu erhöhen.
ES2180757T3 (es) Sintesis enzimatica mejorada de oligosacaridos.
MY103388A (en) Azithromycin and derivatives as antiprotozoal agents
BG46601A3 (bg) Метод за получаване на авермектинови производни
EA200100298A1 (ru) ФАРМАЦЕВТИЧЕСКИЕ ПРЕПАРАТЫ С РЕГУЛИРУЕМЫМ ВЫСВОБОЖДЕНИЕМ, СОДЕРЖАЩИЕ ИНГИБИТОР cGMP-ФОСФОДИЭСТЕРАЗЫ-5
ES8602553A1 (es) Un sistema de purificacion de aguas residuales y un procedi-miento para su ejecucion
FR2714907B1 (fr) Nouveaux dérivés de l'Adénosine, leurs procédés de préparation, compositions pharmaceutiques les contenant.
SE9502474L (sv) Farmaceutiska kompositioner för förhindrande och behandling av cancerösa sjukdomar samt process för beredning av dessa
ATE205850T1 (de) Behandlung der toxischen wirkung von chemotherapeutischen und antiviralen wirkstoffen mit acylierten pyrimidinnukleosiden
RU94046200A (ru) Последовательности днк, производные последовательностей днк, плазмиды, способ применения последовательностей, способ применения плазмид, трансгенные растения
BE892943A (fr) Nouveaux derives 4'-iodo de glycosides d'anthracyclines
DK583785D0 (da) Soedemiddel, fremgangsmaade til fremstilling deraf og anvendelse deraf
FR2687678B1 (fr) Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant.
IT7826293A0 (it) Procedimento per la n-protezione selettiva di amminoglicosidi e prodotti intermedi amminoglicosidi selettivamente protetti cosi'ottenuti.
ES2063796T3 (es) Nuevos derivados de 2'-halometiliden, 2'-eteniliden- y 2'-etinil-adenosina.
FR2722194B1 (fr) Nouveaux derives de benzopyrane, leur procede de preparation et les compositions pharmacuetiques qui les contiennent
FR2574412B1 (fr) Procede de fabrication de derives de nucleosides utiles notamment comme agents anticancereux
FR2668150B1 (fr) Nouveaux derives du terbutylphenyl 1-amino 4-hydroxybutane, leurs procedes de preparation et les compositions pharmaceutiques en renfermant.
OA09481A (fr) "Nouveaux sels de métaux alcalinoterreux d'oxa-polyacides, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent".
MY104067A (en) Epipodophyllotoxin glucoside 4''-acyl derivatives
MA20543A1 (fr) Derives de thierro et furo-[2,3-c]pyroles procedes de preparation les contenant
PT84130A (fr) Procede de preparation de nouveaux derives de 3-alkoxyflavones et de leurs compositions therapeutiques
FR2399845A2 (fr) Adjuvant d'immunotherapie contenant un glycolipide comme ingredient actif et son procede de preparation
BE892032A (fr) Nouveaux derives de 1-benzyl-4-(4-(2-pyrimidinylamino)benzyl-2,3-dioxopiperazines, leurs sels, un procede de preparation de ces derives et sels et un agent carcinostatique les contenant

Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: *BRISTOL-MYERS SQUIBB CY

Effective date: 20080803

CCRE Expiry of a supplementary protection certificate

Free format text: PRODUCT NAME: ETOPOSIDE PHOSPHATE; NAT. REGISTRATION NO/DATE: 203 IS 254 F 12 19970123; FIRST REGISTRATION: SE 12 512 19960412

Spc suppl protection certif: 97C0017

Filing date: 19970320

Expiry date: 20080803

Extension date: 20110412

Effective date: 20090731