FR2622193B1 - Derives d'epipodophyllotoxines glucosides 4'-phosphate leur utilisation et les compositions les contenant - Google Patents

Derives d'epipodophyllotoxines glucosides 4'-phosphate leur utilisation et les compositions les contenant

Info

Publication number
FR2622193B1
FR2622193B1 FR8810258A FR8810258A FR2622193B1 FR 2622193 B1 FR2622193 B1 FR 2622193B1 FR 8810258 A FR8810258 A FR 8810258A FR 8810258 A FR8810258 A FR 8810258A FR 2622193 B1 FR2622193 B1 FR 2622193B1
Authority
FR
France
Prior art keywords
epipodophyllotoxins
glucoside
compositions containing
phosphate derivatives
phosphate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR8810258A
Other languages
English (en)
French (fr)
Other versions
FR2622193A1 (fr
Inventor
G. Saulnier Mark
D. Senter Peter
F. Kadow John
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of FR2622193A1 publication Critical patent/FR2622193A1/fr
Application granted granted Critical
Publication of FR2622193B1 publication Critical patent/FR2622193B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Cable Accessories (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
FR8810258A 1987-08-04 1988-07-29 Derives d'epipodophyllotoxines glucosides 4'-phosphate leur utilisation et les compositions les contenant Expired - Lifetime FR2622193B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8149387A 1987-08-04 1987-08-04
US07/199,731 US4904768A (en) 1987-08-04 1988-05-27 Epipodophyllotoxin glucoside 4'-phosphate derivatives

Publications (2)

Publication Number Publication Date
FR2622193A1 FR2622193A1 (fr) 1989-04-28
FR2622193B1 true FR2622193B1 (fr) 1993-12-17

Family

ID=26765636

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8810258A Expired - Lifetime FR2622193B1 (fr) 1987-08-04 1988-07-29 Derives d'epipodophyllotoxines glucosides 4'-phosphate leur utilisation et les compositions les contenant

Country Status (34)

Country Link
US (3) US4904768A (cg-RX-API-DMAC7.html)
JP (1) JPH0699465B2 (cg-RX-API-DMAC7.html)
KR (1) KR900006230B1 (cg-RX-API-DMAC7.html)
CN (1) CN1027169C (cg-RX-API-DMAC7.html)
AT (1) AT398974B (cg-RX-API-DMAC7.html)
BE (1) BE1002982A4 (cg-RX-API-DMAC7.html)
CA (1) CA1310637C (cg-RX-API-DMAC7.html)
CH (1) CH676716A5 (cg-RX-API-DMAC7.html)
CY (1) CY1625A (cg-RX-API-DMAC7.html)
CZ (1) CZ286893B6 (cg-RX-API-DMAC7.html)
DD (2) DD299067A5 (cg-RX-API-DMAC7.html)
DE (1) DE3826562A1 (cg-RX-API-DMAC7.html)
DK (2) DK169344B1 (cg-RX-API-DMAC7.html)
ES (1) ES2010775A6 (cg-RX-API-DMAC7.html)
FI (1) FI87790C (cg-RX-API-DMAC7.html)
FR (1) FR2622193B1 (cg-RX-API-DMAC7.html)
GB (1) GB2207674B (cg-RX-API-DMAC7.html)
GR (1) GR1000490B (cg-RX-API-DMAC7.html)
HK (1) HK6392A (cg-RX-API-DMAC7.html)
HU (3) HU208147B (cg-RX-API-DMAC7.html)
IE (1) IE61040B1 (cg-RX-API-DMAC7.html)
IL (1) IL87290A (cg-RX-API-DMAC7.html)
IT (1) IT1226825B (cg-RX-API-DMAC7.html)
LU (2) LU87290A1 (cg-RX-API-DMAC7.html)
MX (1) MX173843B (cg-RX-API-DMAC7.html)
MY (1) MY104321A (cg-RX-API-DMAC7.html)
NL (2) NL192683C (cg-RX-API-DMAC7.html)
NO (4) NO170284C (cg-RX-API-DMAC7.html)
NZ (1) NZ225615A (cg-RX-API-DMAC7.html)
PT (1) PT88186B (cg-RX-API-DMAC7.html)
SE (1) SE502214C2 (cg-RX-API-DMAC7.html)
SG (1) SG101291G (cg-RX-API-DMAC7.html)
SK (1) SK541288A3 (cg-RX-API-DMAC7.html)
YU (3) YU143688A (cg-RX-API-DMAC7.html)

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US6610299B1 (en) 1989-10-19 2003-08-26 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US7241595B2 (en) 1989-10-20 2007-07-10 Sanofi-Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US6475486B1 (en) 1990-10-18 2002-11-05 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US5552154A (en) * 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5034380A (en) * 1989-11-20 1991-07-23 Bristol-Myers Squibb Company Alkoxymethylidene epipodophyllotoxin glucosides
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
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US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
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US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
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EP0111058B1 (en) * 1982-11-26 1987-11-04 Nippon Kayaku Kabushiki Kaisha Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
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Also Published As

Publication number Publication date
FI883596A7 (fi) 1989-02-05
FI87790C (fi) 1993-02-25
GB2207674B (en) 1991-09-11
DD299067A5 (de) 1992-03-26
LU90138I2 (fr) 1997-11-26
AT398974B (de) 1995-02-27
US4904768A (en) 1990-02-27
NO1998002I1 (no) 1998-01-14
SK279325B6 (sk) 1998-10-07
PT88186A (pt) 1989-06-30
FI883596A0 (fi) 1988-08-01
YU10390A (en) 1990-06-30
SE8802815L (sv) 1989-02-05
YU143688A (en) 1990-04-30
NL8801934A (nl) 1989-03-01
CN1027169C (zh) 1994-12-28
MX173843B (es) 1994-03-30
HUT47303A (en) 1989-02-28
US5041424A (en) 1991-08-20
CY1625A (en) 1992-07-10
NO920277L (no) 1989-02-24
USRE35524E (en) 1997-06-03
NO170284C (no) 1992-09-30
HU905862D0 (en) 1991-03-28
AU610619B2 (en) 1991-05-23
NZ225615A (en) 1991-06-25
HU208147B (en) 1993-08-30
IE882378L (en) 1989-02-04
DK11992A (da) 1992-01-31
DD274423A5 (de) 1989-12-20
MX9202851A (es) 1992-06-30
IL87290A0 (en) 1989-01-31
IE61040B1 (en) 1994-09-07
CH676716A5 (cg-RX-API-DMAC7.html) 1991-02-28
ATA195588A (de) 1994-07-15
NO920665L (no) 1989-02-24
HK6392A (en) 1992-01-17
NO883299L (no) 1989-02-24
SE8802815D0 (sv) 1988-08-03
DK434088A (da) 1989-02-05
DE3826562C2 (cg-RX-API-DMAC7.html) 1993-04-08
DK434088D0 (da) 1988-08-03
SK541288A3 (en) 1998-10-07
FI87790B (fi) 1992-11-13
LU87290A1 (fr) 1990-02-07
NO920277D0 (no) 1992-01-22
IL87290A (en) 1993-01-31
NL970042I1 (nl) 1998-03-02
CZ541288A3 (cs) 1999-12-15
NO172440B (no) 1993-04-13
NL192683B (cg-RX-API-DMAC7.html) 1997-08-01
IT8821535A0 (it) 1988-07-28
CA1310637C (en) 1992-11-24
AU2030688A (en) 1989-06-08
ES2010775A6 (es) 1989-12-01
KR900006230B1 (ko) 1990-08-27
CZ286893B6 (cs) 2000-07-12
NO172440C (no) 1993-07-21
NO920665D0 (no) 1992-02-20
FR2622193A1 (fr) 1989-04-28
HU202547B (en) 1991-03-28
JPH01100188A (ja) 1989-04-18
PT88186B (pt) 1995-07-03
DE3826562A1 (de) 1989-02-16
GB2207674A (en) 1989-02-08
NO883299D0 (no) 1988-07-26
NL192683C (nl) 1997-12-02
CN1061225A (zh) 1992-05-20
YU10490A (en) 1990-06-30
HU211960A9 (en) 1996-01-29
SE502214C2 (sv) 1995-09-18
DK11992D0 (da) 1992-01-31
KR890003790A (ko) 1989-04-18
MY104321A (en) 1994-03-31
NL970042I2 (cg-RX-API-DMAC7.html) 2005-06-01
DK169344B1 (da) 1994-10-10
NO170284B (no) 1992-06-22
BE1002982A4 (fr) 1991-10-15
SG101291G (en) 1992-01-17
IT1226825B (it) 1991-02-19
GR880100512A (en) 1989-05-25
JPH0699465B2 (ja) 1994-12-07
GR1000490B (el) 1992-07-30
GB8818462D0 (en) 1988-09-07

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