ATE446293T1 - Substituierte pyridinyl- und pyrimidinylderivate als modulatoren des metabolismus und behandlung von damit zusammenhängenden störungen - Google Patents

Substituierte pyridinyl- und pyrimidinylderivate als modulatoren des metabolismus und behandlung von damit zusammenhängenden störungen

Info

Publication number
ATE446293T1
ATE446293T1 AT07023528T AT07023528T ATE446293T1 AT E446293 T1 ATE446293 T1 AT E446293T1 AT 07023528 T AT07023528 T AT 07023528T AT 07023528 T AT07023528 T AT 07023528T AT E446293 T1 ATE446293 T1 AT E446293T1
Authority
AT
Austria
Prior art keywords
modulators
metabolism
treatment
related disorders
substituted pyridinyl
Prior art date
Application number
AT07023528T
Other languages
English (en)
Inventor
David Hurst
Robert M Jones
Amy Siu-Ting Wong
Juerg Lehmann
Young-Jun Shin
Original Assignee
Arena Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arena Pharm Inc filed Critical Arena Pharm Inc
Application granted granted Critical
Publication of ATE446293T1 publication Critical patent/ATE446293T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT07023528T 2005-01-10 2006-01-09 Substituierte pyridinyl- und pyrimidinylderivate als modulatoren des metabolismus und behandlung von damit zusammenhängenden störungen ATE446293T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US64284005P 2005-01-10 2005-01-10

Publications (1)

Publication Number Publication Date
ATE446293T1 true ATE446293T1 (de) 2009-11-15

Family

ID=36755755

Family Applications (2)

Application Number Title Priority Date Filing Date
AT07023528T ATE446293T1 (de) 2005-01-10 2006-01-09 Substituierte pyridinyl- und pyrimidinylderivate als modulatoren des metabolismus und behandlung von damit zusammenhängenden störungen
AT06733644T ATE381558T1 (de) 2005-01-10 2006-01-09 Substituierte pyridinyl und pyrimidinyl derivate als modulatoren eines metabolismus für die behandlung von damit inzusammenhangstehenden krankheiten

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT06733644T ATE381558T1 (de) 2005-01-10 2006-01-09 Substituierte pyridinyl und pyrimidinyl derivate als modulatoren eines metabolismus für die behandlung von damit inzusammenhangstehenden krankheiten

Country Status (36)

Country Link
US (3) US20060155128A1 (de)
EP (2) EP1732562B1 (de)
JP (1) JP2008526882A (de)
KR (1) KR20070098907A (de)
CN (2) CN101115740A (de)
AR (1) AR054320A1 (de)
AT (2) ATE446293T1 (de)
AU (1) AU2006211583C1 (de)
BR (1) BRPI0606704A (de)
CA (1) CA2594466A1 (de)
CR (1) CR9225A (de)
CY (2) CY1107215T1 (de)
DE (2) DE602006000339T2 (de)
DK (2) DK1732562T3 (de)
EA (1) EA015714B1 (de)
ES (2) ES2299167T4 (de)
GE (1) GEP20094828B (de)
GT (1) GT200600006A (de)
HN (2) HN2006000969A (de)
HR (2) HRP20080113T3 (de)
IL (1) IL184363A0 (de)
MX (1) MX2007008402A (de)
MY (1) MY148521A (de)
NI (1) NI200700169A (de)
NO (1) NO20073806L (de)
NZ (1) NZ556220A (de)
PE (2) PE20060857A1 (de)
PL (2) PL1732562T3 (de)
PT (2) PT1732562E (de)
RS (2) RS51007B (de)
SG (1) SG158875A1 (de)
SI (2) SI1732562T1 (de)
TW (1) TW200637845A (de)
UA (1) UA89812C2 (de)
WO (1) WO2006083491A2 (de)
ZA (1) ZA200705471B (de)

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TW200637845A (en) 2006-11-01
GT200600006A (es) 2006-08-23
GEP20094828B (en) 2009-11-25
AU2006211583C1 (en) 2011-09-08

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