DE602007006815D1 - 4-ä5-methoxy-6-(2-methyl-6-ä1,2,4ütriazol-1-yl-pyridin-3-ylamino)-pyrimidin-4-yloxyü-piperidin-1-carbonsäure isopropyl ester als stoffwechselmodulatore und behandlung von damit assoziierten erkrankungen - Google Patents
4-ä5-methoxy-6-(2-methyl-6-ä1,2,4ütriazol-1-yl-pyridin-3-ylamino)-pyrimidin-4-yloxyü-piperidin-1-carbonsäure isopropyl ester als stoffwechselmodulatore und behandlung von damit assoziierten erkrankungenInfo
- Publication number
- DE602007006815D1 DE602007006815D1 DE602007006815T DE602007006815T DE602007006815D1 DE 602007006815 D1 DE602007006815 D1 DE 602007006815D1 DE 602007006815 T DE602007006815 T DE 602007006815T DE 602007006815 T DE602007006815 T DE 602007006815T DE 602007006815 D1 DE602007006815 D1 DE 602007006815D1
- Authority
- DE
- Germany
- Prior art keywords
- utriazol
- ylamino
- yloxy
- piperidin
- pyridin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81927806P | 2006-07-06 | 2006-07-06 | |
PCT/US2007/015670 WO2008005569A2 (en) | 2006-07-06 | 2007-07-05 | Modulators of metabolism and the treatment of disorders related thereto |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602007006815D1 true DE602007006815D1 (de) | 2010-07-08 |
Family
ID=38895258
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602007006815T Active DE602007006815D1 (de) | 2006-07-06 | 2007-07-05 | 4-ä5-methoxy-6-(2-methyl-6-ä1,2,4ütriazol-1-yl-pyridin-3-ylamino)-pyrimidin-4-yloxyü-piperidin-1-carbonsäure isopropyl ester als stoffwechselmodulatore und behandlung von damit assoziierten erkrankungen |
Country Status (31)
Country | Link |
---|---|
US (1) | US20090286816A1 (de) |
EP (1) | EP2051976B1 (de) |
JP (1) | JP2009542699A (de) |
KR (1) | KR20090029781A (de) |
CN (1) | CN101484441A (de) |
AR (1) | AR061968A1 (de) |
AT (1) | ATE469145T1 (de) |
AU (1) | AU2007269571A1 (de) |
BR (1) | BRPI0713998A2 (de) |
CA (1) | CA2656623A1 (de) |
CL (1) | CL2007001971A1 (de) |
CO (1) | CO6160319A2 (de) |
CR (1) | CR10537A (de) |
DE (1) | DE602007006815D1 (de) |
DK (1) | DK2051976T3 (de) |
EA (1) | EA200970088A1 (de) |
EC (1) | ECSP099037A (de) |
ES (1) | ES2344965T3 (de) |
GT (1) | GT200800306A (de) |
HK (1) | HK1128921A1 (de) |
IL (1) | IL195851A0 (de) |
MA (1) | MA30602B1 (de) |
MX (1) | MX2008016253A (de) |
NO (1) | NO20090591L (de) |
PE (1) | PE20080519A1 (de) |
SV (1) | SV2009003146A (de) |
TN (1) | TNSN08533A1 (de) |
TW (1) | TW200811147A (de) |
UY (1) | UY30467A1 (de) |
WO (1) | WO2008005569A2 (de) |
ZA (1) | ZA200900055B (de) |
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RS20050532A (en) | 2003-01-14 | 2007-12-31 | Arena Pharmaceuticals Inc., | 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prpphylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia |
US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
EP2540725A1 (de) | 2006-05-04 | 2013-01-02 | Boehringer Ingelheim International GmbH | Polymorphe von 1-((4-Methyl-chinazolin-2-yl)methyl)-3-methyl-7-(2-butin-1-yl)-8-(3-(R)-amino-piperidin-1-yl)xanthin |
EP1852108A1 (de) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | Zusammensetzungen von DPP-IV-Inhibitoren |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
CN101801954B (zh) | 2007-09-20 | 2013-10-09 | Irm责任有限公司 | 作为gpr119活性调节剂的化合物和组合物 |
PE20140960A1 (es) | 2008-04-03 | 2014-08-15 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
EP2146210A1 (de) | 2008-04-07 | 2010-01-20 | Arena Pharmaceuticals, Inc. | Verfahren zur Verwendung eines AG-Protein-gekoppelten Rezeptors zur Identifikation von Peptid-YY (PPY)-Sekretagogen sowie Verbindungen zur Behandlung durch PYY modulierter Leiden |
KR20190016601A (ko) | 2008-08-06 | 2019-02-18 | 베링거 인겔하임 인터내셔날 게엠베하 | 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료 |
UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
RU2011113823A (ru) * | 2008-09-10 | 2012-10-20 | БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) | Комбинированная терапия, предназначенная для лечения диабета и связанных с ним состояний |
US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
JP2012512848A (ja) | 2008-12-23 | 2012-06-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 有機化合物の塩の形態 |
TW201036975A (en) | 2009-01-07 | 2010-10-16 | Boehringer Ingelheim Int | Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy |
US8410089B2 (en) | 2009-02-18 | 2013-04-02 | Takeda Pharmaceutical Company Limited | Fused heterocyclic ring compound |
WO2010135506A1 (en) * | 2009-05-20 | 2010-11-25 | Janssen Pharmaceutica Nv | Process for the preparation of 4- [6-(6-methanesulfonyl-2-methyl-pyridin-3-ylamino) -5-methoxy-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid isopropyl ester |
NZ596445A (en) | 2009-06-24 | 2013-04-26 | Boehringer Ingelheim Int | New compounds, pharmaceutical composition and methods relating thereto |
JP2012530758A (ja) | 2009-06-24 | 2012-12-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規化合物、医薬組成物及びそれに関する方法 |
NZ599298A (en) | 2009-11-27 | 2014-11-28 | Boehringer Ingelheim Int | Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin |
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WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
WO2011113947A1 (en) | 2010-03-18 | 2011-09-22 | Boehringer Ingelheim International Gmbh | Combination of a gpr119 agonist and the dpp-iv inhibitor linagliptin for use in the treatment of diabetes and related conditions |
JP6034781B2 (ja) | 2010-05-05 | 2016-11-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 併用療法 |
EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
EP3725325B1 (de) | 2010-06-24 | 2023-05-31 | Boehringer Ingelheim International GmbH | Diabetestherapie |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
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WO2012025811A1 (en) | 2010-08-23 | 2012-03-01 | Lupin Limited | Indolylpyrimidines as modulators of gpr119 |
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US9034883B2 (en) | 2010-11-15 | 2015-05-19 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
AU2011333472A1 (en) | 2010-11-26 | 2013-06-06 | Lupin Limited | Bicyclic GPR119 modulators |
WO2012170867A1 (en) | 2011-06-09 | 2012-12-13 | Rhizen Pharmaceuticals Sa | Novel compounds as modulators of gpr-119 |
DK2731947T3 (en) | 2011-07-15 | 2019-04-23 | Boehringer Ingelheim Int | SUBSTITUTED DIMERIC QUINAZOLINE DERIVATIVE, PREPARATION AND USE thereof IN PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF TYPE I AND TYPE II DIABETES |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
EP2849755A1 (de) | 2012-05-14 | 2015-03-25 | Boehringer Ingelheim International GmbH | Xanthinderivat als dpp-4-hemmer zur verwendung bei der behandlung von durch podozyten vermittelten erkrankungen und/oder des nephrotischen syndroms |
WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
EP3028703B1 (de) | 2013-07-29 | 2019-12-04 | Kyowa Kirin Co., Ltd. | Piperidin abkömmlinge als wnt-signalisierungsinhibitor |
JP6615109B2 (ja) | 2014-02-28 | 2019-12-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Dpp−4阻害薬の医学的使用 |
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2007
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- 2007-07-04 PE PE2007000859A patent/PE20080519A1/es not_active Application Discontinuation
- 2007-07-05 MX MX2008016253A patent/MX2008016253A/es active IP Right Grant
- 2007-07-05 AT AT07810278T patent/ATE469145T1/de not_active IP Right Cessation
- 2007-07-05 EA EA200970088A patent/EA200970088A1/ru unknown
- 2007-07-05 AU AU2007269571A patent/AU2007269571A1/en not_active Withdrawn
- 2007-07-05 KR KR1020097000107A patent/KR20090029781A/ko not_active Application Discontinuation
- 2007-07-05 CN CNA2007800250772A patent/CN101484441A/zh not_active Withdrawn
- 2007-07-05 DE DE602007006815T patent/DE602007006815D1/de active Active
- 2007-07-05 US US12/307,549 patent/US20090286816A1/en not_active Abandoned
- 2007-07-05 CL CL2007001971A patent/CL2007001971A1/es unknown
- 2007-07-05 DK DK07810278.7T patent/DK2051976T3/da active
- 2007-07-05 EP EP07810278A patent/EP2051976B1/de active Active
- 2007-07-05 WO PCT/US2007/015670 patent/WO2008005569A2/en active Application Filing
- 2007-07-05 CA CA002656623A patent/CA2656623A1/en not_active Abandoned
- 2007-07-05 ES ES07810278T patent/ES2344965T3/es active Active
- 2007-07-05 BR BRPI0713998-5A patent/BRPI0713998A2/pt not_active IP Right Cessation
- 2007-07-05 JP JP2009518398A patent/JP2009542699A/ja not_active Withdrawn
- 2007-07-06 UY UY30467A patent/UY30467A1/es unknown
- 2007-07-06 AR ARP070103027A patent/AR061968A1/es unknown
-
2008
- 2008-01-05 ZA ZA200900055A patent/ZA200900055B/xx unknown
- 2008-12-10 IL IL195851A patent/IL195851A0/en unknown
- 2008-12-19 CR CR10537A patent/CR10537A/es not_active Application Discontinuation
- 2008-12-24 CO CO08136750A patent/CO6160319A2/es unknown
- 2008-12-25 TN TNP2008000533A patent/TNSN08533A1/en unknown
- 2008-12-29 GT GT200800306A patent/GT200800306A/es unknown
-
2009
- 2009-01-06 SV SV2009003146A patent/SV2009003146A/es unknown
- 2009-01-06 EC EC2009009037A patent/ECSP099037A/es unknown
- 2009-01-27 MA MA31591A patent/MA30602B1/fr unknown
- 2009-02-06 NO NO20090591A patent/NO20090591L/no not_active Application Discontinuation
- 2009-09-09 HK HK09108254.5A patent/HK1128921A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
BRPI0713998A2 (pt) | 2012-11-20 |
ATE469145T1 (de) | 2010-06-15 |
WO2008005569A3 (en) | 2008-04-10 |
JP2009542699A (ja) | 2009-12-03 |
EA200970088A1 (ru) | 2009-06-30 |
NO20090591L (no) | 2009-02-06 |
PE20080519A1 (es) | 2008-05-16 |
CN101484441A (zh) | 2009-07-15 |
SV2009003146A (es) | 2009-11-04 |
US20090286816A1 (en) | 2009-11-19 |
CA2656623A1 (en) | 2008-01-10 |
AR061968A1 (es) | 2008-08-10 |
MX2008016253A (es) | 2009-02-25 |
TW200811147A (en) | 2008-03-01 |
CR10537A (es) | 2009-01-27 |
ES2344965T3 (es) | 2010-09-10 |
AU2007269571A1 (en) | 2008-01-10 |
MA30602B1 (fr) | 2009-07-01 |
TNSN08533A1 (en) | 2010-04-14 |
CO6160319A2 (es) | 2010-05-20 |
ZA200900055B (en) | 2009-12-30 |
DK2051976T3 (da) | 2010-09-20 |
WO2008005569A2 (en) | 2008-01-10 |
KR20090029781A (ko) | 2009-03-23 |
UY30467A1 (es) | 2008-02-29 |
EP2051976B1 (de) | 2010-05-26 |
ECSP099037A (es) | 2009-02-27 |
EP2051976A2 (de) | 2009-04-29 |
GT200800306A (es) | 2009-04-20 |
CL2007001971A1 (es) | 2008-01-25 |
HK1128921A1 (en) | 2009-11-13 |
IL195851A0 (en) | 2009-09-01 |
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