CO6160319A2 - Moduladores del metabolismo y tratamiento de los trastornos metabolicos - Google Patents
Moduladores del metabolismo y tratamiento de los trastornos metabolicosInfo
- Publication number
- CO6160319A2 CO6160319A2 CO08136750A CO08136750A CO6160319A2 CO 6160319 A2 CO6160319 A2 CO 6160319A2 CO 08136750 A CO08136750 A CO 08136750A CO 08136750 A CO08136750 A CO 08136750A CO 6160319 A2 CO6160319 A2 CO 6160319A2
- Authority
- CO
- Colombia
- Prior art keywords
- medicament
- production
- human
- individual
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1.- Un compuesto seleccionado entre los compuestos de fórmula (I): y sus sales, solvatos e hidratos farmacéuticamente aceptables. 2.- Una composición farmacéutica que comprende un compuesto de la reivindicación 1 y un portador farmacéuticamente aceptable.3.- El uso de un compuesto de acuerdo con la reivindicación 1 para la producción de un medicamento para usar en el tratamiento de un trastorno metabólico. 4.- El uso de un compuesto de acuerdo con la reivindicación 1, para la producción de un medicamento para usar en el tratamiento de la diabetes tipo I, la diabetes tipo II, la tolerancia inadecuada a la glucosa, la resistencia a la insulina, la hiperglucemia, la hiperlipidemia, la hipertrigliceridemia, la hipercolesterolemia, la dislipidemia o el síndrome X. 5.- El uso de un compuesto de acuerdo con la reivindicación 1 para la producción de un medicamento para usar en la disminución del consumo de alimentos en un individuo. 6.- El uso de un compuesto de acuerdo con la reivindicación 1 para la producción de un medicamento para usar en la inducción de saciedad en un individuo. 7.- El uso de un compuesto de acuerdo con la reivindicación 1 para la producción de un medicamento para usar en el control o la disminución del aumento de peso en un individuo. 8.- El uso de acuerdo con cualquiera de las reivindicaciones 5 a 7, donde dicho individuo es un mamífero. 9.- El uso de acuerdo con la reivindicación 8, donde dicho mamífero es un ser humano. 10.- El uso de acuerdo con la reivindicación 9, donde dicho ser humano tiene un índice de masa corporal entre aproximadamente 18,5 y aproximadamente 45. 11.- El uso de acuerdo con la reivindicación 9, donde dicho ser humano tiene un índice de masa corporal entre aproximadamente 25 y aproximadamente 45. 12.- El uso de acuerdo con la reivindicación 9, donde dicho ser humano tiene un índice de masa corporal entre aproximadamente 30 y aproximadamente 45.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81927806P | 2006-07-06 | 2006-07-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6160319A2 true CO6160319A2 (es) | 2010-05-20 |
Family
ID=38895258
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO08136750A CO6160319A2 (es) | 2006-07-06 | 2008-12-24 | Moduladores del metabolismo y tratamiento de los trastornos metabolicos |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US20090286816A1 (es) |
| EP (1) | EP2051976B1 (es) |
| JP (1) | JP2009542699A (es) |
| KR (1) | KR20090029781A (es) |
| CN (1) | CN101484441A (es) |
| AR (1) | AR061968A1 (es) |
| AT (1) | ATE469145T1 (es) |
| AU (1) | AU2007269571A1 (es) |
| BR (1) | BRPI0713998A2 (es) |
| CA (1) | CA2656623A1 (es) |
| CL (1) | CL2007001971A1 (es) |
| CO (1) | CO6160319A2 (es) |
| CR (1) | CR10537A (es) |
| DE (1) | DE602007006815D1 (es) |
| DK (1) | DK2051976T3 (es) |
| EA (1) | EA200970088A1 (es) |
| EC (1) | ECSP099037A (es) |
| ES (1) | ES2344965T3 (es) |
| GT (1) | GT200800306A (es) |
| HK (1) | HK1128921A1 (es) |
| IL (1) | IL195851A0 (es) |
| MA (1) | MA30602B1 (es) |
| MX (1) | MX2008016253A (es) |
| NO (1) | NO20090591L (es) |
| PE (1) | PE20080519A1 (es) |
| SV (1) | SV2009003146A (es) |
| TN (1) | TNSN08533A1 (es) |
| TW (1) | TW200811147A (es) |
| UY (1) | UY30467A1 (es) |
| WO (1) | WO2008005569A2 (es) |
| ZA (1) | ZA200900055B (es) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| US8293751B2 (en) | 2003-01-14 | 2012-10-23 | Arena Pharmaceuticals, Inc. | 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia |
| US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
| DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
| DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
| NO347644B1 (no) | 2006-05-04 | 2024-02-12 | Boehringer Ingelheim Int | Polymorfer |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| CA2697551C (en) | 2007-09-20 | 2013-03-12 | Irm Llc | Piperidine derivatives as modulators of gpr119 activity |
| AR071175A1 (es) | 2008-04-03 | 2010-06-02 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende un inhibidor de la dipeptidil-peptidasa-4 (dpp4) y un farmaco acompanante |
| EP2146210A1 (en) | 2008-04-07 | 2010-01-20 | Arena Pharmaceuticals, Inc. | Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditions modulated by PYY |
| UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
| KR20200118243A (ko) | 2008-08-06 | 2020-10-14 | 베링거 인겔하임 인터내셔날 게엠베하 | 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료 |
| MX2011002558A (es) * | 2008-09-10 | 2011-04-26 | Boehringer Ingelheim Int | Terapia de combinacion para el tratamiento de diabetes y estados relacionados. |
| US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
| US8865729B2 (en) | 2008-12-23 | 2014-10-21 | Boehringer Ingelheim International Gmbh | Salt forms of a xanthine compound |
| TW201036975A (en) | 2009-01-07 | 2010-10-16 | Boehringer Ingelheim Int | Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy |
| US8410089B2 (en) | 2009-02-18 | 2013-04-02 | Takeda Pharmaceutical Company Limited | Fused heterocyclic ring compound |
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| WO2010149685A1 (en) | 2009-06-24 | 2010-12-29 | Boehringer Ingelheim International Gmbh | New compounds, pharmaceutical composition and methods relating thereto |
| KR20120046188A (ko) | 2009-06-24 | 2012-05-09 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 신규 화합물, 약제학적 조성물 및 이에 관련된 방법 |
| AU2010323068B2 (en) | 2009-11-27 | 2015-09-03 | Boehringer Ingelheim International Gmbh | Treatment of genotyped diabetic patients with DPP-IV inhibitors such as linagliptin |
| EP3378854B1 (en) | 2010-01-27 | 2022-12-21 | Arena Pharmaceuticals, Inc. | Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2011113947A1 (en) | 2010-03-18 | 2011-09-22 | Boehringer Ingelheim International Gmbh | Combination of a gpr119 agonist and the dpp-iv inhibitor linagliptin for use in the treatment of diabetes and related conditions |
| WO2011138421A1 (en) | 2010-05-05 | 2011-11-10 | Boehringer Ingelheim International Gmbh | Combination therapy |
| US8933024B2 (en) | 2010-06-18 | 2015-01-13 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| KR20190050871A (ko) | 2010-06-24 | 2019-05-13 | 베링거 인겔하임 인터내셔날 게엠베하 | 당뇨병 요법 |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| WO2012025811A1 (en) | 2010-08-23 | 2012-03-01 | Lupin Limited | Indolylpyrimidines as modulators of gpr119 |
| BR112013008100A2 (pt) | 2010-09-22 | 2016-08-09 | Arena Pharm Inc | "moduladores do receptor de gpr19 e o tratamento de distúrbios relacionados a eles." |
| AR083878A1 (es) | 2010-11-15 | 2013-03-27 | Boehringer Ingelheim Int | Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento |
| EP2643311A1 (en) | 2010-11-26 | 2013-10-02 | Lupin Limited | Bicyclic gpr119 modulators |
| EP2718279B1 (en) | 2011-06-09 | 2016-08-10 | Rhizen Pharmaceuticals SA | Novel compounds as modulators of gpr-119 |
| KR101985384B1 (ko) | 2011-07-15 | 2019-06-03 | 베링거 인겔하임 인터내셔날 게엠베하 | 치환된 퀴나졸린, 이의 제조 및 약제학적 조성물에서의 이의 용도 |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
| EP2849755A1 (en) | 2012-05-14 | 2015-03-25 | Boehringer Ingelheim International GmbH | A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome |
| WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
| EP3028703B1 (en) | 2013-07-29 | 2019-12-04 | Kyowa Kirin Co., Ltd. | Piperidine derivatives as wnt signaling inhibitor |
| WO2015128453A1 (en) | 2014-02-28 | 2015-09-03 | Boehringer Ingelheim International Gmbh | Medical use of a dpp-4 inhibitor |
| CN104003942A (zh) * | 2014-03-10 | 2014-08-27 | 常熟市南湖实业化工有限公司 | 避免串温现象产生的5-甲氧基-4,6-二氯嘧啶制备方法 |
| CN116850181A (zh) | 2015-01-06 | 2023-10-10 | 艾尼纳制药公司 | 治疗与s1p1受体有关的病症的方法 |
| CN105111151B (zh) * | 2015-04-17 | 2018-09-28 | 成都理工大学 | 作为PPAR-γ调节剂的氨基嘧啶衍生物 |
| MX2017016530A (es) | 2015-06-22 | 2018-03-12 | Arena Pharm Inc | Sal cristalina de l-arginina del acido (r)-2-(7-(4-ciclopentil-3-( trifluorometil)benciloxi)-1,2,3,4-tetrahidrociclopenta[b]indol-3- il)acetico (compuesto1) para ser utilizada en transtornos asociados con el receptor de esfingosina-1-fosfato 1 (s1p1). |
| US10155000B2 (en) | 2016-06-10 | 2018-12-18 | Boehringer Ingelheim International Gmbh | Medical use of pharmaceutical combination or composition |
| CN110520124A (zh) | 2017-02-16 | 2019-11-29 | 艾尼纳制药公司 | 用于治疗原发性胆汁性胆管炎的化合物和方法 |
| CN108658871B (zh) * | 2018-06-19 | 2020-10-30 | 舞阳威森生物医药有限公司 | 周效磺胺中间体4,6-二氯-5-甲氧基嘧啶的制备方法 |
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| US8293751B2 (en) * | 2003-01-14 | 2012-10-23 | Arena Pharmaceuticals, Inc. | 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia |
| PL378295A1 (pl) * | 2003-02-24 | 2006-03-20 | Arena Pharmaceuticals, Inc. | Podstawione pochodne arylowe i heteroarylowe jako modulatory metabolizmu glukozy oraz profilaktyka i leczenie zaburzeń tego metabolizmu |
| US7083933B1 (en) * | 2003-05-09 | 2006-08-01 | Prosidion Limited | Methods for identification of modulators of OSGPR116 activity |
| AR045047A1 (es) * | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
| WO2005007658A2 (en) * | 2003-07-14 | 2005-01-27 | Arena Pharmaceuticals, Inc. | Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto |
| JP2008501698A (ja) * | 2004-06-04 | 2008-01-24 | アリーナ ファーマシューティカルズ， インコーポレイテッド | 代謝の調節因子としての置換アリールおよびヘテロアリール誘導体ならびにそれらに関連する疾患の予防および処置 |
| MY148521A (en) * | 2005-01-10 | 2013-04-30 | Arena Pharm Inc | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto |
-
2007
- 2007-07-02 TW TW096124029A patent/TW200811147A/zh unknown
- 2007-07-04 PE PE2007000859A patent/PE20080519A1/es not_active Application Discontinuation
- 2007-07-05 EP EP07810278A patent/EP2051976B1/en active Active
- 2007-07-05 AU AU2007269571A patent/AU2007269571A1/en not_active Withdrawn
- 2007-07-05 MX MX2008016253A patent/MX2008016253A/es active IP Right Grant
- 2007-07-05 BR BRPI0713998-5A patent/BRPI0713998A2/pt not_active IP Right Cessation
- 2007-07-05 AT AT07810278T patent/ATE469145T1/de not_active IP Right Cessation
- 2007-07-05 US US12/307,549 patent/US20090286816A1/en not_active Abandoned
- 2007-07-05 CA CA002656623A patent/CA2656623A1/en not_active Abandoned
- 2007-07-05 DE DE602007006815T patent/DE602007006815D1/de active Active
- 2007-07-05 EA EA200970088A patent/EA200970088A1/ru unknown
- 2007-07-05 WO PCT/US2007/015670 patent/WO2008005569A2/en active Application Filing
- 2007-07-05 CL CL2007001971A patent/CL2007001971A1/es unknown
- 2007-07-05 CN CNA2007800250772A patent/CN101484441A/zh not_active Withdrawn
- 2007-07-05 DK DK07810278.7T patent/DK2051976T3/da active
- 2007-07-05 JP JP2009518398A patent/JP2009542699A/ja not_active Withdrawn
- 2007-07-05 KR KR1020097000107A patent/KR20090029781A/ko not_active Application Discontinuation
- 2007-07-05 ES ES07810278T patent/ES2344965T3/es active Active
- 2007-07-06 UY UY30467A patent/UY30467A1/es unknown
- 2007-07-06 AR ARP070103027A patent/AR061968A1/es unknown
-
2008
- 2008-01-05 ZA ZA200900055A patent/ZA200900055B/xx unknown
- 2008-12-10 IL IL195851A patent/IL195851A0/en unknown
- 2008-12-19 CR CR10537A patent/CR10537A/es not_active Application Discontinuation
- 2008-12-24 CO CO08136750A patent/CO6160319A2/es unknown
- 2008-12-25 TN TNP2008000533A patent/TNSN08533A1/en unknown
- 2008-12-29 GT GT200800306A patent/GT200800306A/es unknown
-
2009
- 2009-01-06 SV SV2009003146A patent/SV2009003146A/es unknown
- 2009-01-06 EC EC2009009037A patent/ECSP099037A/es unknown
- 2009-01-27 MA MA31591A patent/MA30602B1/fr unknown
- 2009-02-06 NO NO20090591A patent/NO20090591L/no not_active Application Discontinuation
- 2009-09-09 HK HK09108254.5A patent/HK1128921A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20090286816A1 (en) | 2009-11-19 |
| KR20090029781A (ko) | 2009-03-23 |
| TNSN08533A1 (en) | 2010-04-14 |
| CA2656623A1 (en) | 2008-01-10 |
| EA200970088A1 (ru) | 2009-06-30 |
| ZA200900055B (en) | 2009-12-30 |
| SV2009003146A (es) | 2009-11-04 |
| GT200800306A (es) | 2009-04-20 |
| IL195851A0 (en) | 2009-09-01 |
| TW200811147A (en) | 2008-03-01 |
| UY30467A1 (es) | 2008-02-29 |
| NO20090591L (no) | 2009-02-06 |
| PE20080519A1 (es) | 2008-05-16 |
| EP2051976A2 (en) | 2009-04-29 |
| BRPI0713998A2 (pt) | 2012-11-20 |
| AU2007269571A1 (en) | 2008-01-10 |
| CN101484441A (zh) | 2009-07-15 |
| HK1128921A1 (en) | 2009-11-13 |
| DE602007006815D1 (de) | 2010-07-08 |
| AR061968A1 (es) | 2008-08-10 |
| ES2344965T3 (es) | 2010-09-10 |
| ATE469145T1 (de) | 2010-06-15 |
| CR10537A (es) | 2009-01-27 |
| DK2051976T3 (da) | 2010-09-20 |
| ECSP099037A (es) | 2009-02-27 |
| WO2008005569A3 (en) | 2008-04-10 |
| MX2008016253A (es) | 2009-02-25 |
| MA30602B1 (fr) | 2009-07-01 |
| JP2009542699A (ja) | 2009-12-03 |
| EP2051976B1 (en) | 2010-05-26 |
| WO2008005569A2 (en) | 2008-01-10 |
| CL2007001971A1 (es) | 2008-01-25 |
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