MA30602B1 - Modulateurs du metabolisme, et traitement de troubles au moyen de ces modulateurs - Google Patents
Modulateurs du metabolisme, et traitement de troubles au moyen de ces modulateursInfo
- Publication number
- MA30602B1 MA30602B1 MA31591A MA31591A MA30602B1 MA 30602 B1 MA30602 B1 MA 30602B1 MA 31591 A MA31591 A MA 31591A MA 31591 A MA31591 A MA 31591A MA 30602 B1 MA30602 B1 MA 30602B1
- Authority
- MA
- Morocco
- Prior art keywords
- modulators
- treatment
- metabolism
- disorders
- present
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention concerne l'ester isopropylique de l'acide 4-[5-méthoxy-6-(2-méthyl-6-[1, 2, 4]triazol-1-yl-pyridin-3-ylamino)-pyrimidin-4-yloxy]-pipéridine-1-carboxylique, ses sels pharmaceutiquement acceptables, ses solvates et ses hydrates qui sont des modulateurs du métabolisme du glucose. Les composés selon la présente invention sont utiles pour le traitement de troubles associés au métabolisme et de leurs complications, telles que le diabète et l'obésité.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81927806P | 2006-07-06 | 2006-07-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA30602B1 true MA30602B1 (fr) | 2009-07-01 |
Family
ID=38895258
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA31591A MA30602B1 (fr) | 2006-07-06 | 2009-01-27 | Modulateurs du metabolisme, et traitement de troubles au moyen de ces modulateurs |
Country Status (31)
Country | Link |
---|---|
US (1) | US20090286816A1 (fr) |
EP (1) | EP2051976B1 (fr) |
JP (1) | JP2009542699A (fr) |
KR (1) | KR20090029781A (fr) |
CN (1) | CN101484441A (fr) |
AR (1) | AR061968A1 (fr) |
AT (1) | ATE469145T1 (fr) |
AU (1) | AU2007269571A1 (fr) |
BR (1) | BRPI0713998A2 (fr) |
CA (1) | CA2656623A1 (fr) |
CL (1) | CL2007001971A1 (fr) |
CO (1) | CO6160319A2 (fr) |
CR (1) | CR10537A (fr) |
DE (1) | DE602007006815D1 (fr) |
DK (1) | DK2051976T3 (fr) |
EA (1) | EA200970088A1 (fr) |
EC (1) | ECSP099037A (fr) |
ES (1) | ES2344965T3 (fr) |
GT (1) | GT200800306A (fr) |
HK (1) | HK1128921A1 (fr) |
IL (1) | IL195851A0 (fr) |
MA (1) | MA30602B1 (fr) |
MX (1) | MX2008016253A (fr) |
NO (1) | NO20090591L (fr) |
PE (1) | PE20080519A1 (fr) |
SV (1) | SV2009003146A (fr) |
TN (1) | TNSN08533A1 (fr) |
TW (1) | TW200811147A (fr) |
UY (1) | UY30467A1 (fr) |
WO (1) | WO2008005569A2 (fr) |
ZA (1) | ZA200900055B (fr) |
Families Citing this family (53)
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US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
KR20110010824A (ko) | 2003-01-14 | 2011-02-07 | 아레나 파마슈티칼스, 인크. | 대사 조절제로서의 1,2,3-삼치환된 아릴 및 헤테로아릴 유도체, 및 당뇨병 및 고혈당증을 비롯한 이에 관련된 장애의 예방 및 치료 |
US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
UA97244C2 (en) | 2006-05-04 | 2012-01-25 | Берингер Ингельхайм Интернациональ Гмбх | Polymorphs of 1-((4-methyfquinazolin-2-yl)methyl)-3-methyl-7- (2-butyn-1-yl)-8-(3-(r)-aminopiperidin-l-yl)xanthine |
EP1852108A1 (fr) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | Compositions d'inhibiteurs de la DPP IV |
EP2025674A1 (fr) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament |
CN101801954B (zh) | 2007-09-20 | 2013-10-09 | Irm责任有限公司 | 作为gpr119活性调节剂的化合物和组合物 |
PE20140960A1 (es) | 2008-04-03 | 2014-08-15 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
EP2146210A1 (fr) | 2008-04-07 | 2010-01-20 | Arena Pharmaceuticals, Inc. | Procédés d'utilisation du récepteur couplé aux protéines A G pour identifier les secrétagogues de peptide YY (PYY) et composés utiles dans le traitement d'états modulés par PYY |
KR20190016601A (ko) | 2008-08-06 | 2019-02-18 | 베링거 인겔하임 인터내셔날 게엠베하 | 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료 |
UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
AU2009290911A1 (en) | 2008-09-10 | 2010-03-18 | Boehringer Ingelheim International Gmbh | Combination therapy for the treatment of diabetes and related conditions |
US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
CN102256976A (zh) | 2008-12-23 | 2011-11-23 | 贝林格尔.英格海姆国际有限公司 | 有机化合物的盐形式 |
TW201036975A (en) | 2009-01-07 | 2010-10-16 | Boehringer Ingelheim Int | Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy |
US8410089B2 (en) | 2009-02-18 | 2013-04-02 | Takeda Pharmaceutical Company Limited | Fused heterocyclic ring compound |
US20100298362A1 (en) * | 2009-05-20 | 2010-11-25 | Xun Li | Process for the preparation of 4-[6-(6-methanesulfonyl-2-methyl-pyridin-3-ylamino)-5-methoxy-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid isopropyl ester |
JP2012530758A (ja) | 2009-06-24 | 2012-12-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規化合物、医薬組成物及びそれに関する方法 |
JP5467151B2 (ja) | 2009-06-24 | 2014-04-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規化合物、医薬組成物及びそれに関する方法 |
KR20190071840A (ko) | 2009-11-27 | 2019-06-24 | 베링거 인겔하임 인터내셔날 게엠베하 | 리나글립틴과 같은 dpp-iv 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료 |
EP2528894A1 (fr) | 2010-01-27 | 2012-12-05 | Arena Pharmaceuticals, Inc. | Procédés de préparation d'acide (r)-2-(7-(4-cyclopentyl-3-(trifluorométhyl)benzyloxy)-1,2,3,4-tétrahydrocyclopenta[b]indol-3-yl) acétique et de ses sels |
WO2011107494A1 (fr) | 2010-03-03 | 2011-09-09 | Sanofi | Nouveaux dérivés aromatiques de glycoside, médicaments contenants ces composés, et leur utilisation |
WO2011113947A1 (fr) | 2010-03-18 | 2011-09-22 | Boehringer Ingelheim International Gmbh | Combinaisons d'agonistes de gpr119 et d'inhibiteurs de dpp-iv, linagliptine, pour le traitement du diabète et d'états apparentés |
ES2935300T3 (es) | 2010-05-05 | 2023-03-03 | Boehringer Ingelheim Int | Combiterapia |
EP2582709B1 (fr) | 2010-06-18 | 2018-01-24 | Sanofi | Dérivés d'azolopyridin-3-one en tant qu'inhibiteurs de lipases et de phospholipases |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
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TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
WO2012025811A1 (fr) | 2010-08-23 | 2012-03-01 | Lupin Limited | Composés indolylpyrimidines en tant que modulateurs de gpr119 |
BR112013008100A2 (pt) | 2010-09-22 | 2016-08-09 | Arena Pharm Inc | "moduladores do receptor de gpr19 e o tratamento de distúrbios relacionados a eles." |
AR083878A1 (es) | 2010-11-15 | 2013-03-27 | Boehringer Ingelheim Int | Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento |
EP2643311A1 (fr) | 2010-11-26 | 2013-10-02 | Lupin Limited | Modulateurs de gpr119 bicycliques |
CA2836487A1 (fr) | 2011-06-09 | 2012-12-13 | Rhizen Pharmaceuticals Sa | Nouveaux composes utilises comme modulateurs de gpr-119 |
US8883800B2 (en) | 2011-07-15 | 2014-11-11 | Boehringer Ingelheim International Gmbh | Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions |
WO2013037390A1 (fr) | 2011-09-12 | 2013-03-21 | Sanofi | Dérivés amides d'acide 6-(4-hydroxyphényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase |
WO2013045413A1 (fr) | 2011-09-27 | 2013-04-04 | Sanofi | Dérivés d'amide d'acide 6-(4-hydroxyphényl)-3-alkyl-1h-pyrazolo[3,4-b] pyridine-4-carboxylique utilisés comme inhibiteurs de kinase |
US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
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US9771351B2 (en) | 2013-07-29 | 2017-09-26 | Kyowa Hakko Kirin Co., Ltd. | Wnt signaling inhibitor |
JP6615109B2 (ja) | 2014-02-28 | 2019-12-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Dpp−4阻害薬の医学的使用 |
CN104003942A (zh) * | 2014-03-10 | 2014-08-27 | 常熟市南湖实业化工有限公司 | 避免串温现象产生的5-甲氧基-4,6-二氯嘧啶制备方法 |
EP3242666A1 (fr) | 2015-01-06 | 2017-11-15 | Arena Pharmaceuticals, Inc. | Procédés de traitement de maladies associées au récepteur s1p1 |
CN105111151B (zh) * | 2015-04-17 | 2018-09-28 | 成都理工大学 | 作为PPAR-γ调节剂的氨基嘧啶衍生物 |
KR20230160955A (ko) | 2015-06-22 | 2023-11-24 | 아레나 파마슈티칼스, 인크. | S1p1 수용체-관련 장애에서의 사용을 위한 (r)-2-(7-(4-시클로펜틸-3-(트리플루오로메틸)벤질옥시)-1,2,3,4-테트라히드로시클로-펜타[b]인돌-3-일)아세트산 (화합물 1)의 결정성 l-아르기닌 염 |
EP3468562A1 (fr) | 2016-06-10 | 2019-04-17 | Boehringer Ingelheim International GmbH | Combinaisons de linagliptine et de metformine |
EP3582772A1 (fr) | 2017-02-16 | 2019-12-25 | Arena Pharmaceuticals, Inc. | Composés et méthodes de traitement de l'angiocholite biliaire primitive |
CN108658871B (zh) * | 2018-06-19 | 2020-10-30 | 舞阳威森生物医药有限公司 | 周效磺胺中间体4,6-二氯-5-甲氧基嘧啶的制备方法 |
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KR20110010824A (ko) * | 2003-01-14 | 2011-02-07 | 아레나 파마슈티칼스, 인크. | 대사 조절제로서의 1,2,3-삼치환된 아릴 및 헤테로아릴 유도체, 및 당뇨병 및 고혈당증을 비롯한 이에 관련된 장애의 예방 및 치료 |
JP2006518763A (ja) * | 2003-02-24 | 2006-08-17 | アリーナ ファーマシューティカルズ, インコーポレイテッド | グルコース代謝のモジュレーターとしてのフェニル−およびピリジルピペリジン誘導体 |
US7083933B1 (en) * | 2003-05-09 | 2006-08-01 | Prosidion Limited | Methods for identification of modulators of OSGPR116 activity |
AR045047A1 (es) * | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
MY157911A (en) * | 2003-07-14 | 2016-08-15 | Arena Pharm Inc | Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto |
ES2320359T3 (es) | 2004-06-04 | 2009-05-21 | Arena Pharmaceuticals, Inc. | Moduladores del metabolismo y la profilaxis y tratamiento de trastornos relacionados con los mismos. |
MY148521A (en) * | 2005-01-10 | 2013-04-30 | Arena Pharm Inc | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto |
-
2007
- 2007-07-02 TW TW096124029A patent/TW200811147A/zh unknown
- 2007-07-04 PE PE2007000859A patent/PE20080519A1/es not_active Application Discontinuation
- 2007-07-05 US US12/307,549 patent/US20090286816A1/en not_active Abandoned
- 2007-07-05 EP EP07810278A patent/EP2051976B1/fr active Active
- 2007-07-05 EA EA200970088A patent/EA200970088A1/ru unknown
- 2007-07-05 CN CNA2007800250772A patent/CN101484441A/zh not_active Withdrawn
- 2007-07-05 CL CL2007001971A patent/CL2007001971A1/es unknown
- 2007-07-05 AT AT07810278T patent/ATE469145T1/de not_active IP Right Cessation
- 2007-07-05 JP JP2009518398A patent/JP2009542699A/ja not_active Withdrawn
- 2007-07-05 CA CA002656623A patent/CA2656623A1/fr not_active Abandoned
- 2007-07-05 DK DK07810278.7T patent/DK2051976T3/da active
- 2007-07-05 WO PCT/US2007/015670 patent/WO2008005569A2/fr active Application Filing
- 2007-07-05 DE DE602007006815T patent/DE602007006815D1/de active Active
- 2007-07-05 ES ES07810278T patent/ES2344965T3/es active Active
- 2007-07-05 KR KR1020097000107A patent/KR20090029781A/ko not_active Application Discontinuation
- 2007-07-05 BR BRPI0713998-5A patent/BRPI0713998A2/pt not_active IP Right Cessation
- 2007-07-05 MX MX2008016253A patent/MX2008016253A/es active IP Right Grant
- 2007-07-05 AU AU2007269571A patent/AU2007269571A1/en not_active Withdrawn
- 2007-07-06 UY UY30467A patent/UY30467A1/es unknown
- 2007-07-06 AR ARP070103027A patent/AR061968A1/es unknown
-
2008
- 2008-01-05 ZA ZA200900055A patent/ZA200900055B/xx unknown
- 2008-12-10 IL IL195851A patent/IL195851A0/en unknown
- 2008-12-19 CR CR10537A patent/CR10537A/es not_active Application Discontinuation
- 2008-12-24 CO CO08136750A patent/CO6160319A2/es unknown
- 2008-12-25 TN TNP2008000533A patent/TNSN08533A1/en unknown
- 2008-12-29 GT GT200800306A patent/GT200800306A/es unknown
-
2009
- 2009-01-06 SV SV2009003146A patent/SV2009003146A/es unknown
- 2009-01-06 EC EC2009009037A patent/ECSP099037A/es unknown
- 2009-01-27 MA MA31591A patent/MA30602B1/fr unknown
- 2009-02-06 NO NO20090591A patent/NO20090591L/no not_active Application Discontinuation
- 2009-09-09 HK HK09108254.5A patent/HK1128921A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
WO2008005569A3 (fr) | 2008-04-10 |
EA200970088A1 (ru) | 2009-06-30 |
ZA200900055B (en) | 2009-12-30 |
ES2344965T3 (es) | 2010-09-10 |
EP2051976B1 (fr) | 2010-05-26 |
AU2007269571A1 (en) | 2008-01-10 |
HK1128921A1 (en) | 2009-11-13 |
IL195851A0 (en) | 2009-09-01 |
EP2051976A2 (fr) | 2009-04-29 |
GT200800306A (es) | 2009-04-20 |
WO2008005569A2 (fr) | 2008-01-10 |
JP2009542699A (ja) | 2009-12-03 |
TW200811147A (en) | 2008-03-01 |
KR20090029781A (ko) | 2009-03-23 |
TNSN08533A1 (en) | 2010-04-14 |
CA2656623A1 (fr) | 2008-01-10 |
CN101484441A (zh) | 2009-07-15 |
SV2009003146A (es) | 2009-11-04 |
UY30467A1 (es) | 2008-02-29 |
ATE469145T1 (de) | 2010-06-15 |
CR10537A (es) | 2009-01-27 |
CO6160319A2 (es) | 2010-05-20 |
MX2008016253A (es) | 2009-02-25 |
DK2051976T3 (da) | 2010-09-20 |
ECSP099037A (es) | 2009-02-27 |
US20090286816A1 (en) | 2009-11-19 |
DE602007006815D1 (de) | 2010-07-08 |
CL2007001971A1 (es) | 2008-01-25 |
AR061968A1 (es) | 2008-08-10 |
NO20090591L (no) | 2009-02-06 |
PE20080519A1 (es) | 2008-05-16 |
BRPI0713998A2 (pt) | 2012-11-20 |
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