MA29685B1 - Composes spiroheterocycliques et leurs utilisations en tant qu'agents therapeutiques - Google Patents

Composes spiroheterocycliques et leurs utilisations en tant qu'agents therapeutiques

Info

Publication number
MA29685B1
MA29685B1 MA30345A MA30345A MA29685B1 MA 29685 B1 MA29685 B1 MA 29685B1 MA 30345 A MA30345 A MA 30345A MA 30345 A MA30345 A MA 30345A MA 29685 B1 MA29685 B1 MA 29685B1
Authority
MA
Morocco
Prior art keywords
compounds
therapeutic agents
spiroheterocyclic
spiroheterocyclic compounds
relates
Prior art date
Application number
MA30345A
Other languages
English (en)
Inventor
Mikhail Chafeev
Sultan Chowdhury
Robert Fraser
Jianmin Fu
Rajender Kamboj
Serguei Sviridov
Mehran Seid Bagherzadeh
Shifeng Liu
Jianyu Sun
Original Assignee
Xenon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenon Pharmaceuticals Inc filed Critical Xenon Pharmaceuticals Inc
Publication of MA29685B1 publication Critical patent/MA29685B1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A—HUMAN NECESSITIES
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    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Child & Adolescent Psychology (AREA)

Abstract

Cette invention concerne des composés spirohétérocycliques de formule (I) : dans laquelle k, j, p, Q, R1, R3a, R3b, R3c et R3d sont tels que définis dans le présent document, ainsi que leurs stéréoisomères, énantiomères, tautomères ou des mélanges de ceux-ci ; ou leurs sels, solvates ou promédicaments pharmaceutiquement acceptables, utiles pour le traitement et/ou la prévention de pathologies ou de troubles induits par le canal sodium. L'invention concerne également des compositions pharmaceutiques comprenant les composés et procédés d'utilisation de ces composés.
MA30345A 2005-04-11 2007-10-30 Composes spiroheterocycliques et leurs utilisations en tant qu'agents therapeutiques MA29685B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US67096205P 2005-04-11 2005-04-11

Publications (1)

Publication Number Publication Date
MA29685B1 true MA29685B1 (fr) 2008-08-01

Family

ID=36694990

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30345A MA29685B1 (fr) 2005-04-11 2007-10-30 Composes spiroheterocycliques et leurs utilisations en tant qu'agents therapeutiques

Country Status (27)

Country Link
US (2) US7799798B2 (fr)
EP (1) EP1888592B1 (fr)
JP (1) JP2008535916A (fr)
KR (1) KR20080007250A (fr)
CN (2) CN101967150A (fr)
AR (1) AR053710A1 (fr)
AT (1) ATE504587T1 (fr)
AU (1) AU2006235329B2 (fr)
BR (1) BRPI0608995A2 (fr)
CA (1) CA2604010A1 (fr)
DE (1) DE602006021169D1 (fr)
EC (1) ECSP077848A (fr)
ES (1) ES2362908T3 (fr)
HR (1) HRP20070499A2 (fr)
IL (1) IL186615A0 (fr)
MA (1) MA29685B1 (fr)
MX (1) MX2007012637A (fr)
MY (1) MY145694A (fr)
NO (1) NO20074620L (fr)
NZ (1) NZ561204A (fr)
PL (1) PL1888592T3 (fr)
RU (1) RU2428424C2 (fr)
SG (1) SG161264A1 (fr)
TN (1) TNSN07384A1 (fr)
TW (1) TW200720278A (fr)
WO (1) WO2006110654A1 (fr)
ZA (1) ZA200709004B (fr)

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AR056968A1 (es) * 2005-04-11 2007-11-07 Xenon Pharmaceuticals Inc Compuestos espiro-oxindol y composiciones farmacéuticas
MY145694A (en) 2005-04-11 2012-03-30 Xenon Pharmaceuticals Inc Spiroheterocyclic compounds and their uses as therapeutic agents
AR053713A1 (es) * 2005-04-20 2007-05-16 Xenon Pharmaceuticals Inc Compuestos heterociclicos y sus usos como agentes terapeuticos
JP2010522690A (ja) * 2006-10-12 2010-07-08 ゼノン・ファーマシューティカルズ・インコーポレイテッド 三環式スピロオキシインドール誘導体および治療薬としてのその使用
RU2009117605A (ru) * 2006-10-12 2010-11-20 Ксенон Фармасьютикалз Инк. (Ca) ПРОИЗВОДНЫЕ СПИРО-(ФУРО[3,2-c]ПИРИДИН-3-3'-ИНДОЛ)-2'(1'H)-ОНА И РОДСТВЕННЫЕ ИМ СОЕДИНЕНИЯ ДЛЯ ЛЕЧЕНИЯ ОПОСРЕДОВАННЫХ НАТРИЕВЫМИ КАНАЛАМИ ЗАБОЛЕВАНИЙ, ТАКИХ КАК БОЛЬ
TW200833698A (en) * 2006-10-12 2008-08-16 Xenon Pharmaceuticals Inc Spiroheterocyclic compounds and their uses as therapeutic agents
WO2008046082A2 (fr) * 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Utilisation de composés hétérocycliques comme agents thérapeutiques
WO2008046087A2 (fr) * 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Composés spiro et leurs utilisations en tant qu'agents thérapeutiques
WO2008060789A2 (fr) * 2006-10-12 2008-05-22 Xenon Pharmaceuticals Inc. Utilisation de composés de spiro-oxindole comme agents thérapeutiques
CN101641090B (zh) * 2006-12-19 2012-12-05 亚勒斯有限公司 莫达非尼在制备治疗多动腿综合征的药物中的应用
US7795228B2 (en) * 2006-12-28 2010-09-14 Theracos, Inc. Spiroheterocyclic glycosides and methods of use
CA2685942A1 (fr) * 2007-05-16 2008-11-27 Merck & Co., Inc. Spiroindalones
US20100204247A1 (en) * 2007-10-04 2010-08-12 Duffy Joseph L N-substituted oxindoline derivatives as calcium channel blockers
EP2209373B1 (fr) * 2007-10-04 2012-05-23 Merck Sharp & Dohme Corp. Dérivés d'oxindoline n-substituée comme bloqueurs de canaux calciques
UA101004C2 (en) 2007-12-13 2013-02-25 Теракос, Инк. Derivatives of benzylphenylcyclohexane and use thereof
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