NO20074620L - Spiroheterocykliske forbindelser og deres anvendelse som medikamenter - Google Patents

Spiroheterocykliske forbindelser og deres anvendelse som medikamenter

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Publication number
NO20074620L
NO20074620L NO20074620A NO20074620A NO20074620L NO 20074620 L NO20074620 L NO 20074620L NO 20074620 A NO20074620 A NO 20074620A NO 20074620 A NO20074620 A NO 20074620A NO 20074620 L NO20074620 L NO 20074620L
Authority
NO
Norway
Prior art keywords
heterocyclic compounds
spiro heterocyclic
drugs
compounds
tautomer
Prior art date
Application number
NO20074620A
Other languages
English (en)
Inventor
Serguei Sviridov
Rajender Kamboj
Shifeng Liu
Sultan Chowdhury
Mikhail Chafeev
Robert Fraser
Jianmin Fu
Mehran Seid Bagherzadeh
Jianyu Sun
Original Assignee
Xenon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenon Pharmaceuticals Inc filed Critical Xenon Pharmaceuticals Inc
Publication of NO20074620L publication Critical patent/NO20074620L/no

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Pain & Pain Management (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
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  • Hospice & Palliative Care (AREA)
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Abstract

Foreliggende oppfinnelse angår spiro-heterocykliske forbindelser med formel (I) : hvor , k, j, p, Q, R1, R3a, R3b, R3c og R3d er som definert her, som en stereoisomer, enantiomer, tautomer derav eller blandinger derav; eller et farmasøytisk akseptabelt salt, solvat eller prodrug derav, som er anvendelige for behandling og/eller forebygging av natriumkanal-medierte sykdommer eller tilstander, så som smerte. Farmasøytiske preparater som omfatter forbindelsene, samt metoder for anvendelse av forbindelsene, er også beskrevet.
NO20074620A 2005-04-11 2007-09-12 Spiroheterocykliske forbindelser og deres anvendelse som medikamenter NO20074620L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67096205P 2005-04-11 2005-04-11
PCT/US2006/013318 WO2006110654A1 (en) 2005-04-11 2006-04-11 Spiroheterocyclic compounds and their uses as therapeutic agents

Publications (1)

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NO20074620L true NO20074620L (no) 2007-11-07

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NO20074620A NO20074620L (no) 2005-04-11 2007-09-12 Spiroheterocykliske forbindelser og deres anvendelse som medikamenter

Country Status (27)

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US (2) US7799798B2 (no)
EP (1) EP1888592B1 (no)
JP (1) JP2008535916A (no)
KR (1) KR20080007250A (no)
CN (2) CN101166744A (no)
AR (1) AR053710A1 (no)
AT (1) ATE504587T1 (no)
AU (1) AU2006235329B2 (no)
BR (1) BRPI0608995A2 (no)
CA (1) CA2604010A1 (no)
DE (1) DE602006021169D1 (no)
EC (1) ECSP077848A (no)
ES (1) ES2362908T3 (no)
HR (1) HRP20070499A2 (no)
IL (1) IL186615A0 (no)
MA (1) MA29685B1 (no)
MX (1) MX2007012637A (no)
MY (1) MY145694A (no)
NO (1) NO20074620L (no)
NZ (1) NZ561204A (no)
PL (1) PL1888592T3 (no)
RU (1) RU2428424C2 (no)
SG (1) SG161264A1 (no)
TN (1) TNSN07384A1 (no)
TW (1) TW200720278A (no)
WO (1) WO2006110654A1 (no)
ZA (1) ZA200709004B (no)

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AR056968A1 (es) * 2005-04-11 2007-11-07 Xenon Pharmaceuticals Inc Compuestos espiro-oxindol y composiciones farmacéuticas
AR053713A1 (es) * 2005-04-20 2007-05-16 Xenon Pharmaceuticals Inc Compuestos heterociclicos y sus usos como agentes terapeuticos
MX2009003876A (es) * 2006-10-12 2009-05-11 Xenon Pharmaceuticals Inc Uso de compuestos de espiro-oxindol como agentes terapeuticos.
WO2008046082A2 (en) * 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Use of heterocyclic compounds as therapeutic agents
AR063277A1 (es) * 2006-10-12 2009-01-14 Xenon Pharmaceuticals Inc Compuestos espiroheterociclicos y usos como agentes terapeuticos
WO2008046087A2 (en) * 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Spiro compounds and their uses as therapeutic agents
CA2666143A1 (en) * 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Spiro (furo [3, 2-c] pyridine-3-3 ' -indol) -2' (1'h)-one derivatives and related compounds for the treatment of sodium-channel mediated diseases, such as pain
MX2009003874A (es) * 2006-10-12 2009-04-22 Xenon Pharmaceuticals Inc Derivados de espiro-oxindol triciclicos y sus usos como agentes terapeuticos.
US20100010092A1 (en) * 2006-12-19 2010-01-14 Arless Ltd. Use of modafinil to treat restless leg syndrome
US7795228B2 (en) * 2006-12-28 2010-09-14 Theracos, Inc. Spiroheterocyclic glycosides and methods of use
CA2685942A1 (en) * 2007-05-16 2008-11-27 Merck & Co., Inc. Spiroindalones
US8273749B2 (en) * 2007-10-04 2012-09-25 Merck Sharp & Dohme Corp. N-substituted oxindoline derivatives as calcium channel blockers
JP2010540628A (ja) * 2007-10-04 2010-12-24 メルク・シャープ・エンド・ドーム・コーポレイション カルシウムチャネル遮断薬としてのｎ−置換されたオキシインドリン誘導体
UA101004C2 (en) 2007-12-13 2013-02-25 Теракос, Инк. Derivatives of benzylphenylcyclohexane and use thereof
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