WO2010132352A3 - Spiro compounds and their use as therapeutic agents - Google Patents

Spiro compounds and their use as therapeutic agents Download PDF

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Publication number
WO2010132352A3
WO2010132352A3 PCT/US2010/034223 US2010034223W WO2010132352A3 WO 2010132352 A3 WO2010132352 A3 WO 2010132352A3 US 2010034223 W US2010034223 W US 2010034223W WO 2010132352 A3 WO2010132352 A3 WO 2010132352A3
Authority
WO
WIPO (PCT)
Prior art keywords
spiro compounds
therapeutic agents
tautomers
prodrugs
solvates
Prior art date
Application number
PCT/US2010/034223
Other languages
French (fr)
Other versions
WO2010132352A2 (en
Inventor
Jianmin Fu
Shifeng Liu
Shaoyi Sun
Mark Wood
Original Assignee
Xenon Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenon Pharmaceuticals Inc. filed Critical Xenon Pharmaceuticals Inc.
Publication of WO2010132352A2 publication Critical patent/WO2010132352A2/en
Publication of WO2010132352A3 publication Critical patent/WO2010132352A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Abstract

This invention is directed to spiro compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
PCT/US2010/034223 2009-05-11 2010-05-10 Spiro compounds and their use as therapeutic agents WO2010132352A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17719109P 2009-05-11 2009-05-11
US61/177,191 2009-05-11

Publications (2)

Publication Number Publication Date
WO2010132352A2 WO2010132352A2 (en) 2010-11-18
WO2010132352A3 true WO2010132352A3 (en) 2011-09-01

Family

ID=42236478

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/034223 WO2010132352A2 (en) 2009-05-11 2010-05-10 Spiro compounds and their use as therapeutic agents

Country Status (1)

Country Link
WO (1) WO2010132352A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR056968A1 (en) 2005-04-11 2007-11-07 Xenon Pharmaceuticals Inc ESPIRO-OXINDOL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS
EP2073806B1 (en) 2006-10-12 2012-02-15 Xenon Pharmaceuticals Inc. Use of spiro-oxindole compounds as therapeutic agents
CN102256983B (en) 2008-10-17 2017-04-05 泽农医药公司 Spiral shell oxindole compounds and its purposes as therapeutic agent
US8101647B2 (en) 2008-10-17 2012-01-24 Xenon Pharmaceuticals Inc. Spiro-oxindole compounds and their use as therapeutic agents
AR077252A1 (en) 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc ESPIROOXINDOL COMPOUND ENANTIOMERS AND THEIR USES AS THERAPEUTIC AGENTS
CN102753556B (en) 2009-10-14 2015-05-13 泽农医药公司 Synthetic methods for spiro-oxindole compounds
BR112012021086A2 (en) 2010-02-26 2016-05-17 Xenon Pharmaceuticals Inc pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents
AU2013246485A1 (en) * 2012-04-12 2014-10-16 Xenon Pharmaceuticals Inc. Asymmetric syntheses for spiro-oxindole compounds useful as therapeutic agents
CN104098577B (en) * 2014-07-12 2016-05-11 台州学院 A kind of high-efficiency synthesis method of azoles diindyl ketone condensed hetero ring
WO2016127068A1 (en) 2015-02-05 2016-08-11 Teva Pharmaceuticals International Gmbh Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008046084A2 (en) * 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Spiroheterocyclic compounds and their uses as therapeutic agents

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008046084A2 (en) * 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Spiroheterocyclic compounds and their uses as therapeutic agents

Also Published As

Publication number Publication date
WO2010132352A2 (en) 2010-11-18

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