WO2008147864A3 - Methods of using piperazine compounds in treating sodium channel-mediated diseases or conditions - Google Patents
Methods of using piperazine compounds in treating sodium channel-mediated diseases or conditions Download PDFInfo
- Publication number
- WO2008147864A3 WO2008147864A3 PCT/US2008/064498 US2008064498W WO2008147864A3 WO 2008147864 A3 WO2008147864 A3 WO 2008147864A3 US 2008064498 W US2008064498 W US 2008064498W WO 2008147864 A3 WO2008147864 A3 WO 2008147864A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- conditions
- sodium channel
- mediated diseases
- methods
- piperazine compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
This invention is directed to piperazine compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93958607P | 2007-05-22 | 2007-05-22 | |
US60/939,586 | 2007-05-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008147864A2 WO2008147864A2 (en) | 2008-12-04 |
WO2008147864A3 true WO2008147864A3 (en) | 2009-07-09 |
Family
ID=40075732
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/064498 WO2008147864A2 (en) | 2007-05-22 | 2008-05-22 | Methods of using piperazine compounds in treating sodium channel-mediated diseases or conditions |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008147864A2 (en) |
Cited By (2)
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CN104398516A (en) * | 2009-02-20 | 2015-03-11 | 阿斯利康(瑞典)有限公司 | Cyclopropyl amide derivatives targeting the histamine h3 receptor |
CN110204511B (en) * | 2019-06-27 | 2023-04-11 | 南京神奇科技开发有限公司 | Thymol amino alcohol and preparation method and application thereof |
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AU2006290442B2 (en) | 2005-09-16 | 2010-07-29 | Arrow Therapeutics Limited | Biphenyl derivatives and their use in treating hepatitis C |
CA2685266C (en) | 2007-04-27 | 2014-01-28 | Purdue Pharma L.P. | Trpv1 antagonists and uses thereof for the treatment of prevention of pain, ui and ulcer, ibd, or ibs in an animal |
SI2195293T1 (en) | 2007-08-22 | 2014-02-28 | Astrazeneca Ab | Cycloptopyl amide derivatives |
US8673920B2 (en) | 2009-05-06 | 2014-03-18 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
TW201139406A (en) * | 2010-01-14 | 2011-11-16 | Glaxo Group Ltd | Voltage-gated sodium channel blockers |
SG183274A1 (en) | 2010-02-18 | 2012-09-27 | Astrazeneca Ab | Processes for making cyclopropyl amide derivatives and intermediates associated therewith |
WO2012020567A1 (en) * | 2010-08-09 | 2012-02-16 | Raqualia Pharma Inc. | Acyl piperazine derivatives as ttx-s blockers |
WO2012058116A1 (en) | 2010-10-27 | 2012-05-03 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9056859B2 (en) | 2010-10-29 | 2015-06-16 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
EP2723732B1 (en) | 2011-06-22 | 2017-01-18 | Purdue Pharma LP | Trpv1 antagonists including dihydroxy substituent and uses thereof |
US20140121213A1 (en) * | 2011-07-06 | 2014-05-01 | Jeffrey Charles Boehm | Voltage-gated sodium channel blockers |
BR112014003801A2 (en) | 2011-08-19 | 2017-03-07 | Merck Sharp & Dohme | compound, pharmaceutical composition, and methods for inhibiting romk, causing diuresis, natriuresis or both, and treating or prophylaxis of one or more disorders |
WO2013039802A1 (en) | 2011-09-16 | 2013-03-21 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
WO2013062900A1 (en) | 2011-10-25 | 2013-05-02 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
WO2013062892A1 (en) | 2011-10-25 | 2013-05-02 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
WO2013066717A1 (en) | 2011-10-31 | 2013-05-10 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
EP2773199B1 (en) | 2011-10-31 | 2019-04-10 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
EP2773351B1 (en) | 2011-10-31 | 2017-08-23 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
WO2013090271A1 (en) | 2011-12-16 | 2013-06-20 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
AR092031A1 (en) | 2012-07-26 | 2015-03-18 | Merck Sharp & Dohme | INHIBITORS OF THE EXTERNAL RENAL MEDULAR POTASSIUM CHANNEL |
EP2925322B1 (en) | 2012-11-29 | 2018-10-24 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
EP2934533B1 (en) | 2012-12-19 | 2017-11-15 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
EP2956142B1 (en) | 2013-02-18 | 2017-09-20 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
WO2014150132A1 (en) | 2013-03-15 | 2014-09-25 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
EP3027625B1 (en) | 2013-07-31 | 2018-05-30 | Merck Sharp & Dohme Corp. | Spiro-fused derivatives of piperidine useful for the treatment of inter alia hypertension and acute or chronic heart failure |
WO2016127358A1 (en) | 2015-02-12 | 2016-08-18 | Merck Sharp & Dohme Corp. | Inhibitors of renal outer medullary potassium channel |
KR102093409B1 (en) * | 2019-10-23 | 2020-03-25 | 고려대학교 산학협력단 | Anti-fungal Composition Comprising Carbazole Compound |
CN111662288B (en) * | 2020-06-23 | 2022-06-14 | 徐州医科大学 | Small molecule compound for inhibiting AKT and STAT3 activity and application thereof |
WO2023283608A1 (en) * | 2021-07-07 | 2023-01-12 | Trustees Of Tufts College | Compounds for modulating mycobacterium tuberculosis response |
Citations (8)
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---|---|---|---|---|
US5354747A (en) * | 1993-06-16 | 1994-10-11 | G. D. Searle & Co. | 2-, 3-, 4-, 5-, 6-, 7-, 8-, 9- and/or 10-substituted dibenzoxazepine and dibenzthiazepine compounds, pharmaceutical compositions and methods of use |
WO1996037489A1 (en) * | 1995-05-25 | 1996-11-28 | Fujisawa Pharmaceutical Co., Ltd. | 1-benzoyl-2-(indolyl-3-alkyl)-piperazine derivatives as neurokinin receptor antagonists |
WO1997043259A1 (en) * | 1996-05-10 | 1997-11-20 | Monash University | Arylalkylpiperazine compounds as antioxidants |
US20040034019A1 (en) * | 2002-08-08 | 2004-02-19 | Ronald Tomlinson | Piperazine and piperidine derivatives |
WO2004032933A1 (en) * | 2002-10-11 | 2004-04-22 | Kowa Co., Ltd. | Method for treatment of cancer |
US20050227999A1 (en) * | 2004-04-09 | 2005-10-13 | Neuromed Technologies Inc. | Diarylamine derivatives as calcium channel blockers |
WO2006028904A1 (en) * | 2004-09-02 | 2006-03-16 | Vertex Pharmaceuticals Incorporated | Quinazolines useful as modulators of ion channels |
WO2007109324A2 (en) * | 2006-03-21 | 2007-09-27 | Xenon Pharmaceuticals, Inc. | Potent and selective nav 1.7 sodium channel blockers |
-
2008
- 2008-05-22 WO PCT/US2008/064498 patent/WO2008147864A2/en active Application Filing
Patent Citations (8)
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US5354747A (en) * | 1993-06-16 | 1994-10-11 | G. D. Searle & Co. | 2-, 3-, 4-, 5-, 6-, 7-, 8-, 9- and/or 10-substituted dibenzoxazepine and dibenzthiazepine compounds, pharmaceutical compositions and methods of use |
WO1996037489A1 (en) * | 1995-05-25 | 1996-11-28 | Fujisawa Pharmaceutical Co., Ltd. | 1-benzoyl-2-(indolyl-3-alkyl)-piperazine derivatives as neurokinin receptor antagonists |
WO1997043259A1 (en) * | 1996-05-10 | 1997-11-20 | Monash University | Arylalkylpiperazine compounds as antioxidants |
US20040034019A1 (en) * | 2002-08-08 | 2004-02-19 | Ronald Tomlinson | Piperazine and piperidine derivatives |
WO2004032933A1 (en) * | 2002-10-11 | 2004-04-22 | Kowa Co., Ltd. | Method for treatment of cancer |
US20050227999A1 (en) * | 2004-04-09 | 2005-10-13 | Neuromed Technologies Inc. | Diarylamine derivatives as calcium channel blockers |
WO2006028904A1 (en) * | 2004-09-02 | 2006-03-16 | Vertex Pharmaceuticals Incorporated | Quinazolines useful as modulators of ion channels |
WO2007109324A2 (en) * | 2006-03-21 | 2007-09-27 | Xenon Pharmaceuticals, Inc. | Potent and selective nav 1.7 sodium channel blockers |
Non-Patent Citations (2)
Title |
---|
CARCELLER E ET AL: "(Pyridylcyanomethyl)piperazines as Orally Active PAF Antagonists", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON.; US, vol. 35, no. 22, 30 October 1992 (1992-10-30), pages 4118 - 4134, XP002008877, ISSN: 0022-2623 * |
CLARE J J ET AL: "Voltage-Gated Sodium Channels as Therapeutic Targets", DRUG DISCOVERY TODAY, ELSEVIER, RAHWAY, NJ, US, vol. 5, no. 11, 1 November 2000 (2000-11-01), pages 506 - 520, XP002985023, ISSN: 1359-6446 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104398516A (en) * | 2009-02-20 | 2015-03-11 | 阿斯利康(瑞典)有限公司 | Cyclopropyl amide derivatives targeting the histamine h3 receptor |
CN110204511B (en) * | 2019-06-27 | 2023-04-11 | 南京神奇科技开发有限公司 | Thymol amino alcohol and preparation method and application thereof |
Also Published As
Publication number | Publication date |
---|---|
WO2008147864A2 (en) | 2008-12-04 |
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