HRP20070499A2 - Spiroheterociklički spojevi i njihova uporaba kaoterapijskih sredstava - Google Patents

Spiroheterociklički spojevi i njihova uporaba kaoterapijskih sredstava

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Publication number
HRP20070499A2
HRP20070499A2 HR20070499A HRP20070499A HRP20070499A2 HR P20070499 A2 HRP20070499 A2 HR P20070499A2 HR 20070499 A HR20070499 A HR 20070499A HR P20070499 A HRP20070499 A HR P20070499A HR P20070499 A2 HRP20070499 A2 HR P20070499A2
Authority
HR
Croatia
Prior art keywords
compounds
therapeutic agents
spiroheterocyclic
spiroheterocyclic compounds
tautomers
Prior art date
Application number
HR20070499A
Other languages
English (en)
Inventor
Chafeev Mikhail
Chowdhury Sultan
Fraser Robert
Fu Jianmin
Kamboj Rajender
Sviridov Serguei
Seid Bagherzadeh Mehran
Liu Shifeng
Sun Jianyu
Original Assignee
Xenon Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenon Pharmaceuticals Inc. filed Critical Xenon Pharmaceuticals Inc.
Publication of HRP20070499A2 publication Critical patent/HRP20070499A2/hr

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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

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  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
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Abstract

Ovaj izum je usmjeren na spiroheterocikličke spojeve formule (I): gdje k, j, p, Q, R1, R3a, R3b, R3c i R3d su kao što je ovdje definirano, njihove stereoizomere, enantiomere, tautomere ili njihove smjese; farmaceutski prihvatljive soli, solvate ili njihove prolijekove, koji su korisni za liječenje i/ili prevenciju bolesti ili stanja posredovanih natrijevim kanalima, kao što je bol. Također su otkriveni farmaceutski pripravci koji sadrže spojeve i postupke uporabe spojeva.
HR20070499A 2005-04-11 2007-10-25 Spiroheterociklički spojevi i njihova uporaba kaoterapijskih sredstava HRP20070499A2 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67096205P 2005-04-11 2005-04-11
PCT/US2006/013318 WO2006110654A1 (en) 2005-04-11 2006-04-11 Spiroheterocyclic compounds and their uses as therapeutic agents

Publications (1)

Publication Number Publication Date
HRP20070499A2 true HRP20070499A2 (hr) 2007-12-31

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ID=36694990

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HR20070499A HRP20070499A2 (hr) 2005-04-11 2007-10-25 Spiroheterociklički spojevi i njihova uporaba kaoterapijskih sredstava

Country Status (27)

Country Link
US (2) US7799798B2 (hr)
EP (1) EP1888592B1 (hr)
JP (1) JP2008535916A (hr)
KR (1) KR20080007250A (hr)
CN (2) CN101967150A (hr)
AR (1) AR053710A1 (hr)
AT (1) ATE504587T1 (hr)
AU (1) AU2006235329B2 (hr)
BR (1) BRPI0608995A2 (hr)
CA (1) CA2604010A1 (hr)
DE (1) DE602006021169D1 (hr)
EC (1) ECSP077848A (hr)
ES (1) ES2362908T3 (hr)
HR (1) HRP20070499A2 (hr)
IL (1) IL186615A0 (hr)
MA (1) MA29685B1 (hr)
MX (1) MX2007012637A (hr)
MY (1) MY145694A (hr)
NO (1) NO20074620L (hr)
NZ (1) NZ561204A (hr)
PL (1) PL1888592T3 (hr)
RU (1) RU2428424C2 (hr)
SG (1) SG161264A1 (hr)
TN (1) TNSN07384A1 (hr)
TW (1) TW200720278A (hr)
WO (1) WO2006110654A1 (hr)
ZA (1) ZA200709004B (hr)

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MY145694A (en) 2005-04-11 2012-03-30 Xenon Pharmaceuticals Inc Spiroheterocyclic compounds and their uses as therapeutic agents
AR056968A1 (es) * 2005-04-11 2007-11-07 Xenon Pharmaceuticals Inc Compuestos espiro-oxindol y composiciones farmacéuticas
AR053713A1 (es) * 2005-04-20 2007-05-16 Xenon Pharmaceuticals Inc Compuestos heterociclicos y sus usos como agentes terapeuticos
CA2666136A1 (en) * 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Tricyclic spiro-oxindole derivatives and their uses as therapeutic agents
MX2009003876A (es) 2006-10-12 2009-05-11 Xenon Pharmaceuticals Inc Uso de compuestos de espiro-oxindol como agentes terapeuticos.
CL2007002953A1 (es) * 2006-10-12 2008-02-01 Xenon Pharmaceuticals Inc Compuestos derivados de espiro-oxindol; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento del dolor, cancer, prurito, hiperplasia prostatica benigna, hipercolesterolemia.
WO2008046065A1 (en) * 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Spiroheterocyclic compounds and their uses as therapeutic agents
WO2008046082A2 (en) * 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Use of heterocyclic compounds as therapeutic agents
WO2008046087A2 (en) * 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Spiro compounds and their uses as therapeutic agents
CN101641090B (zh) * 2006-12-19 2012-12-05 亚勒斯有限公司 莫达非尼在制备治疗多动腿综合征的药物中的应用
US7795228B2 (en) 2006-12-28 2010-09-14 Theracos, Inc. Spiroheterocyclic glycosides and methods of use
CN101678011B (zh) * 2007-05-16 2012-07-18 默沙东公司 螺氮茚酮化合物
WO2009045386A1 (en) * 2007-10-04 2009-04-09 Merck & Co., Inc. N-substituted oxindoline derivatives as calcium channel blockers
EP2205079A4 (en) 2007-10-04 2010-10-27 Merck Sharp & Dohme N-SUBSTITUTED OXINDOLINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS
UA101004C2 (en) 2007-12-13 2013-02-25 Теракос, Инк. Derivatives of benzylphenylcyclohexane and use thereof
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