AR047706A1 - Inhibidores de polimerasa viral - Google Patents
Inhibidores de polimerasa viralInfo
- Publication number
- AR047706A1 AR047706A1 ARP050100580A ARP050100580A AR047706A1 AR 047706 A1 AR047706 A1 AR 047706A1 AR P050100580 A ARP050100580 A AR P050100580A AR P050100580 A ARP050100580 A AR P050100580A AR 047706 A1 AR047706 A1 AR 047706A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- cycloalkyl
- case
- independently selected
- halogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54621304P | 2004-02-20 | 2004-02-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR047706A1 true AR047706A1 (es) | 2006-02-08 |
Family
ID=34886250
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050100580A AR047706A1 (es) | 2004-02-20 | 2005-02-18 | Inhibidores de polimerasa viral |
ARP130103893A AR093144A2 (es) | 2004-02-20 | 2013-10-25 | Inhibidores de polimerasa viral |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP130103893A AR093144A2 (es) | 2004-02-20 | 2013-10-25 | Inhibidores de polimerasa viral |
Country Status (30)
Country | Link |
---|---|
US (3) | US7582770B2 (da) |
EP (2) | EP2626354A1 (da) |
JP (4) | JP4648333B2 (da) |
KR (2) | KR101320907B1 (da) |
CN (6) | CN102911161A (da) |
AR (2) | AR047706A1 (da) |
AU (1) | AU2005215829C1 (da) |
BR (1) | BRPI0507861A (da) |
CA (1) | CA2553879C (da) |
DK (1) | DK1718608T3 (da) |
EA (3) | EA201301284A1 (da) |
EC (1) | ECSP066780A (da) |
ES (1) | ES2431314T3 (da) |
HR (1) | HRP20130971T1 (da) |
IL (2) | IL177537A (da) |
IN (1) | IN2012DN04853A (da) |
MY (1) | MY144718A (da) |
NO (1) | NO20064004L (da) |
NZ (1) | NZ549079A (da) |
PE (1) | PE20051141A1 (da) |
PL (1) | PL1718608T3 (da) |
PT (1) | PT1718608E (da) |
RS (1) | RS52931B (da) |
SG (2) | SG184700A1 (da) |
SI (1) | SI1718608T1 (da) |
TW (2) | TWI368507B (da) |
UA (2) | UA86962C2 (da) |
UY (1) | UY28758A1 (da) |
WO (1) | WO2005080388A1 (da) |
ZA (1) | ZA200605151B (da) |
Families Citing this family (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL129407A0 (en) | 1996-10-18 | 2000-02-17 | Vertex Pharma | Inhibitors of serine proteases particularly hepatitis C virus NS3 protease pharmaceutical compositions containing the same and the use thereof |
SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
EP2335700A1 (en) * | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
US20050075279A1 (en) * | 2002-10-25 | 2005-04-07 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
US7098231B2 (en) * | 2003-01-22 | 2006-08-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US7223785B2 (en) * | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
PE20050374A1 (es) | 2003-09-05 | 2005-05-30 | Vertex Pharma | Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc |
ES2431314T3 (es) * | 2004-02-20 | 2013-11-26 | Boehringer Ingelheim International Gmbh | Inhibidores de polimerasa vírica |
EP1771169A1 (en) | 2004-07-14 | 2007-04-11 | PTC Therapeutics, Inc. | Methods for treating hepatitis c |
US7772271B2 (en) | 2004-07-14 | 2010-08-10 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7868037B2 (en) | 2004-07-14 | 2011-01-11 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
WO2006019832A1 (en) | 2004-07-22 | 2006-02-23 | Ptc Therapeutics, Inc. | Thienopyridines for treating hepatitis c |
US7153848B2 (en) | 2004-08-09 | 2006-12-26 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
MY141025A (en) | 2004-10-29 | 2010-02-25 | Vertex Pharma | Dose forms |
KR20070112165A (ko) * | 2005-02-11 | 2007-11-22 | 베링거 인겔하임 인터내셔날 게엠베하 | 2,3-이치환된 인돌의 제조방법 |
JP5015154B2 (ja) * | 2005-08-12 | 2012-08-29 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ウイルスポリメラーゼインヒビター |
US7964624B1 (en) | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
US7816348B2 (en) | 2006-02-03 | 2010-10-19 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US8039475B2 (en) | 2006-02-27 | 2011-10-18 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical compositions comprising the same |
KR20080112303A (ko) | 2006-03-16 | 2008-12-24 | 버텍스 파마슈티칼스 인코포레이티드 | 중수소화 c형 간염 프로테아제 억제제 |
GB0608928D0 (en) | 2006-05-08 | 2006-06-14 | Angeletti P Ist Richerche Bio | Therapeutic agents |
BRPI0716060A2 (pt) | 2006-08-17 | 2013-09-17 | Boehringer Ingelheim Int | inibidores de polimerase viral. |
US7999001B2 (en) * | 2007-01-15 | 2011-08-16 | The United States Of America As Represented By The Secretary Of The Army | Antiviral compounds and methods of using thereof |
US8575208B2 (en) | 2007-02-27 | 2013-11-05 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
ES2379905T3 (es) | 2007-02-27 | 2012-05-04 | Vertex Pharmceuticals Incorporated | Co-cristales y composiciones farmacéuticas que los comprenden |
US8258116B2 (en) | 2007-05-04 | 2012-09-04 | Vertex Pharmaceuticals Incorporated | Combination therapy for the treatment of HCV infection |
EP2178886A1 (en) | 2007-07-17 | 2010-04-28 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Macrocyclic indole derivatives for the treatment of hepatitis c infections |
EP2188274A4 (en) | 2007-08-03 | 2011-05-25 | Boehringer Ingelheim Int | VIRAL POLYMERASE HEMMER |
CL2008002549A1 (es) | 2007-08-30 | 2010-09-03 | Vertex Pharma | Cocristal que comprende vx-950 y un formador de cocristal seleccionado de acido 3-metoxi-4hidroxibenzoico,acido 2,4-dihidroxibenzoico y acido 2,5-dihidroxibenzoico; metodo de preparacion; composicion farmaceutica que comprende el cocristal, util como agente antiviral en el tratamiento del hcv. |
MX2010006210A (es) | 2007-12-05 | 2010-08-10 | Enanta Pharm Inc | Inhibidores de serina proteasa de hcv de tripeptido fluorado. |
JP5623289B2 (ja) | 2007-12-19 | 2014-11-12 | ベーリンガーインゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ウイルスポリメラーゼインヒビター |
AR072297A1 (es) | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
BRPI0917458A2 (pt) | 2008-08-11 | 2015-12-01 | Glaxosmithkline Llc | composto, método de tratamento de doenças e condições, composição farmacêutica, método para tratar ou prevenir doença, e, uso de um composto |
UA103195C2 (uk) | 2008-08-11 | 2013-09-25 | Глаксосмитклайн Ллк | Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань |
LT2320905T (lt) | 2008-08-11 | 2017-09-11 | Glaxosmithkline Llc | Naujieji adenino dariniai |
AU2009293493B2 (en) * | 2008-09-17 | 2014-09-18 | Boehringer Ingelheim International Gmbh | Combination of HCV NS3 protease inhibitor with interferon and ribavirin |
JP2012051803A (ja) * | 2008-12-25 | 2012-03-15 | Kyorin Pharmaceutical Co Ltd | 環状アミノ安息香酸エステル誘導体の製造方法 |
KR20110116136A (ko) | 2009-01-07 | 2011-10-25 | 싸이넥시스, 인크. | Hcv 및 hiv 감염의 치료에 사용하기 위한 사이클로스포린 유도체 |
WO2010093843A2 (en) | 2009-02-12 | 2010-08-19 | Vertex Pharmaceuticals Incorporated | Hcv combination therapies |
WO2010114896A1 (en) | 2009-03-31 | 2010-10-07 | Arqule, Inc. | Substituted indolo-pyridinone compounds |
WO2010132163A1 (en) | 2009-05-13 | 2010-11-18 | Enanta Pharmaceuticals, Inc. | Macrocyclic compounds as hepatitis c virus inhibitors |
RS53856B1 (en) * | 2009-06-11 | 2015-08-31 | Abbvie Bahamas Ltd. | HETEROCYCLIC COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS |
US8937150B2 (en) * | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
WO2010149359A1 (en) * | 2009-06-26 | 2010-12-29 | Lonza Ltd | Process and intermediates for the preparation of benzimidazolecarboxylic acids |
US8354419B2 (en) * | 2009-07-16 | 2013-01-15 | Vertex Pharmaceuticals Incorporated | Benzimidazole analogues for the treatment or prevention of flavivirus infections |
BR112012010110A2 (pt) | 2009-10-30 | 2019-09-24 | Boehringer Ingelheim Int | regimes de dosagem para terapia combinada para hcv compreendendo bi201335, interferon alfa e ribavirina |
JP2013518124A (ja) | 2010-01-29 | 2013-05-20 | バーテックス ファーマシューティカルズ インコーポレイテッド | C型肝炎ウイルス感染の処置のための治療法 |
PT2534149E (pt) | 2010-02-10 | 2014-12-23 | Glaxosmithkline Llc | Maleato de 6-amino-2-{[(1s)-1-metilbutil]oxi}-9-[5-(1- piperidinil)pentil]-7,9-di-hidro-8h-purin-8-ona |
US8575340B2 (en) | 2010-02-10 | 2013-11-05 | Glaxosmithkline Llc | Purine derivatives and their pharmaceutical uses |
WO2011156545A1 (en) | 2010-06-09 | 2011-12-15 | Vertex Pharmaceuticals Incorporated | Viral dynamic model for hcv combination therapy |
TW201208704A (en) | 2010-07-14 | 2012-03-01 | Vertex Pharma | Palatable pharmaceutical composition |
CA2812261C (en) | 2010-09-21 | 2017-02-21 | Enanta Pharmaceuticals, Inc. | Macrocyclic proline derived hcv serine protease inhibitors |
CN103153987A (zh) * | 2010-09-30 | 2013-06-12 | 贝林格尔.英格海姆国际有限公司 | 固态形式的强效hcv抑制剂 |
AP2013006734A0 (en) | 2010-09-30 | 2013-02-28 | Boehringer Ingelheim Int | Combination therapy for treating HCV infection |
WO2012109646A1 (en) | 2011-02-11 | 2012-08-16 | Vertex Pharmaceuticals Incorporated | Treatment of hcv in hiv infection patients |
US20130195797A1 (en) | 2012-01-31 | 2013-08-01 | Vertex Pharmaceuticals Incorporated | High potency formulations of vx-950 |
WO2013147749A1 (en) | 2012-03-27 | 2013-10-03 | Boehringer Ingelheim International Gmbh | Oral combination therapy for treating hcv infection in specific patient subgenotype populations |
WO2013147750A1 (en) | 2012-03-27 | 2013-10-03 | Boehringer Ingelheim International Gmbh | Oral combination therapy for treating hcv infection in specific patient sub-population |
US20130261134A1 (en) | 2012-03-30 | 2013-10-03 | Boehringer Ingelheim International Gmbh | Mesylate salt forms of a potent hcv inhibitor |
WO2014138374A1 (en) | 2013-03-08 | 2014-09-12 | Boehringer Ingelheim International Gmbh | Oral combination therapy for treating hcv infection in specific patient sub-population |
CN103408430B (zh) * | 2013-08-30 | 2014-09-17 | 南京理工大学 | 一种2-甲基-4-硝基苯甲酸的合成方法 |
RU2676684C2 (ru) | 2014-02-20 | 2019-01-10 | ГлаксоСмитКлайн Интеллекчуал Проперти (No.2) Лимитед | ПРОИЗВОДНЫЕ ПИРРОЛО[3,2-d]ПИРИМИДИНА В КАЧЕСТВЕ ИНДУКТОРОВ ЧЕЛОВЕЧЕСКОГО ИНТЕРФЕРОНА |
CN104130143B (zh) * | 2014-08-06 | 2017-02-15 | 江苏鼎龙科技有限公司 | 3‑甲氨基‑4‑硝基苯氧乙醇的制备方法 |
EP3218377B1 (en) | 2014-11-13 | 2022-04-13 | GlaxoSmithKline Biologicals SA | Adenine derivatives which are useful in the treatment of allergic diseases or other inflammatory conditions |
RU2020113165A (ru) | 2015-12-03 | 2020-06-09 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Циклические пуриновые динуклеотиды в качестве модуляторов sting |
JP2019510802A (ja) | 2016-04-07 | 2019-04-18 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | タンパク質調節物質として有用な複素環アミド |
CN113549110A (zh) | 2016-04-07 | 2021-10-26 | 葛兰素史密斯克莱知识产权发展有限公司 | 用作蛋白质调节剂的杂环酰胺 |
CN105884627A (zh) * | 2016-04-22 | 2016-08-24 | 成都东电艾尔科技有限公司 | 一种氧烯洛尔药物中间体邻氨基苯酚的合成方法 |
EP3241830A1 (de) | 2016-05-04 | 2017-11-08 | Bayer CropScience Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
JP6997420B2 (ja) | 2016-08-15 | 2022-01-17 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | 有害生物防除剤としての縮合二環式ヘテロ環誘導体 |
JOP20190024A1 (ar) * | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
WO2019069269A1 (en) | 2017-10-05 | 2019-04-11 | Glaxosmithkline Intellectual Property Development Limited | INTERFERON GENE STIMULATOR MODULATORS USEFUL IN THE TREATMENT OF HIV |
JP7291130B2 (ja) | 2017-10-05 | 2023-06-14 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド | インターフェロン遺伝子の刺激物質(sting)の調節物質 |
EP3755700B1 (de) | 2018-02-21 | 2021-11-24 | Bayer Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
GB201807924D0 (en) | 2018-05-16 | 2018-06-27 | Ctxt Pty Ltd | Compounds |
JP2022533390A (ja) | 2019-05-16 | 2022-07-22 | スティングセラ インコーポレイテッド | オキソアクリジニル酢酸誘導体および使用方法 |
US20220251079A1 (en) | 2019-05-16 | 2022-08-11 | Stingthera, Inc. | Benzo[b][1,8]naphthyridine acetic acid derivatives and methods of use |
GB201910304D0 (en) | 2019-07-18 | 2019-09-04 | Ctxt Pty Ltd | Compounds |
GB201910305D0 (en) | 2019-07-18 | 2019-09-04 | Ctxt Pty Ltd | Compounds |
US20230357125A1 (en) * | 2022-05-06 | 2023-11-09 | AMPAC Fine Chemicals | Process for Catalytic Reduction of Nitro Compounds to Amines |
CN115304584B (zh) * | 2022-07-25 | 2023-05-26 | 云南大学 | 3-硫甲基-(5’-芳基-1h-吡唑)-吲哚类化合物及其制备方法和用途 |
Family Cites Families (208)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1094903A (en) | 1964-03-26 | 1967-12-13 | Smith Kline French Lab | Improvements in or relating to nitrofuran derivatives |
FR1604809A (en) | 1965-11-26 | 1972-04-17 | Thiazolyl benzimidazoles - animal feed additives | |
GB1186504A (en) | 1966-10-15 | 1970-04-02 | Fisons Pest Control Ltd | Substituted Heterocyclic Compounds |
NL6917115A (da) | 1968-11-22 | 1970-05-26 | ||
US3565912A (en) | 1969-01-27 | 1971-02-23 | Upjohn Co | 5-lower-alkanoyl-2,3-bis(p-methoxyphenyl)indoles |
DE2346316C2 (de) | 1973-09-14 | 1985-02-14 | Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von 2-Furylbenzimidazolen |
GB1509527A (en) | 1974-06-05 | 1978-05-04 | Ici Ltd | 1-(aryl-or heteroaryl)oxy-3-(substituted-amino)propan-2-ol derivatives processes for their manufacture and pharmaceutical compositions containing them |
FR2291749A1 (fr) | 1974-11-20 | 1976-06-18 | Delalande Sa | Nouveaux benzimidazoles acetiques, leur procede de preparation et leur application en therapeutique |
US4003908A (en) | 1976-03-11 | 1977-01-18 | E. R. Squibb & Sons, Inc. | Derivatives of imidazo(4,5-b)pyridines |
CH632628B (de) | 1976-07-26 | Ciba Geigy Ag | Verfahren zur herstellung von benzofuranyl-benzimidazolen und deren verwendung als optische aufheller. | |
DE2641060A1 (de) | 1976-09-11 | 1978-03-16 | Hoechst Ag | Beta-lactamverbindungen und verfahren zu ihrer herstellung |
US4264325A (en) | 1977-02-22 | 1981-04-28 | Ciba-Geigy Corporation | Phenyl-benzimidazolyl-furanes for optical brightening of organic materials |
DE2720111A1 (de) | 1977-05-05 | 1978-11-16 | Agfa Gevaert Ag | Korrosionsschutzmittel fuer zweibad-stabilisatorbaeder |
DE2964427D1 (en) | 1978-10-04 | 1983-02-03 | Ciba Geigy Ag | Process for the preparation of furanyl-benzazoles |
ZA795239B (en) | 1978-10-12 | 1980-11-26 | Glaxo Group Ltd | Heterocyclic compounds |
DE2852531A1 (de) | 1978-12-05 | 1980-06-19 | Bayer Ag | Benzofuranyl-benzimidazole |
DE2853765A1 (de) | 1978-12-13 | 1980-06-26 | Bayer Ag | Verfahren zur herstellung von benzimidazolylbenzofuranen |
DE2904829A1 (de) | 1979-02-08 | 1980-08-14 | Bayer Ag | Verfahren zur herstellung von benzimidazolylbenzofuran |
EP0029003B1 (de) | 1979-11-01 | 1984-12-05 | Ciba-Geigy Ag | Salze kationischer Aufheller, deren Herstellung und deren Verwendung auf organischen Materialien sowie deren konzentrierte wässrige Lösungen |
GR75101B (da) | 1980-10-23 | 1984-07-13 | Pfizer | |
GB8707798D0 (en) | 1987-04-01 | 1987-05-07 | Ici Plc | Recovery of metals |
ZA825413B (en) | 1981-08-26 | 1983-06-29 | Pfizer | Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them |
GB2118552A (en) | 1982-04-15 | 1983-11-02 | Pfizer Ltd | Thromboxane synthetase inhibitors |
JPS60149502A (ja) | 1984-01-12 | 1985-08-07 | Kuraray Co Ltd | インド−ル系農園芸用殺菌剤 |
LU85544A1 (fr) | 1984-09-19 | 1986-04-03 | Cird | Derives heterocycliques aromatiques,leur procede de preparation et leur application dans les domaines therapeutique et cosmetique |
DE3522230A1 (de) | 1985-06-21 | 1987-01-02 | Thomae Gmbh Dr K | Neue 2-arylimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
GB8609175D0 (en) | 1986-04-15 | 1986-05-21 | Ici America Inc | Heterocyclic carboxamides |
GB8707051D0 (en) | 1986-04-15 | 1987-04-29 | Ici America Inc | Heterocyclic carboxamides |
US4859684A (en) | 1986-09-15 | 1989-08-22 | Janssen Pharmaceutica N.V. | (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives and use thereof in treating androgen dependent disorders |
US4957932A (en) | 1987-11-25 | 1990-09-18 | Merck Frosst Canada, Inc. | Benzoheterazoles |
JP2700475B2 (ja) | 1988-07-30 | 1998-01-21 | コニカ株式会社 | 非線形光学材料および非線形光学素子 |
JPH03157646A (ja) | 1989-11-15 | 1991-07-05 | Konica Corp | ハロゲン化銀写真感光材料 |
JPH03219232A (ja) | 1990-01-24 | 1991-09-26 | Konica Corp | 分光増感されたハロゲン化銀写真感光材料 |
CA2077897A1 (en) | 1990-04-13 | 1991-10-14 | Robert G. Franz | Substituted benzimidazoles |
JP2909645B2 (ja) | 1990-05-28 | 1999-06-23 | コニカ株式会社 | ハロゲン化銀カラー写真感光材料 |
US5110494A (en) | 1990-08-24 | 1992-05-05 | Man-Gill Chemical Company | Alkaline cleaner and process for reducing stain on aluminum surfaces |
ATE177634T1 (de) | 1990-12-14 | 1999-04-15 | Smithkline Beecham Corp | Angiotensin-ii-rezeptor blockierende zusammensetzungen |
US5527819A (en) | 1991-09-06 | 1996-06-18 | Merck & Co., Inc. | Inhibitors of HIV reverse transcriptase |
PT100905A (pt) | 1991-09-30 | 1994-02-28 | Eisai Co Ltd | Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem |
GB9121463D0 (en) | 1991-10-10 | 1991-11-27 | Smithkline Beecham Corp | Medicament |
GB9122590D0 (en) | 1991-10-24 | 1991-12-04 | Lilly Industries Ltd | Pharmaceutical compounds |
JPH05165163A (ja) | 1991-12-11 | 1993-06-29 | Konica Corp | 色素画像形成方法 |
JP3013124B2 (ja) | 1991-12-26 | 2000-02-28 | コニカ株式会社 | カラー画像形成方法 |
US5216003A (en) | 1992-01-02 | 1993-06-01 | G. D. Searle & Co. | Diacid-containing benzimidazole compounds for treatment of neurotoxic injury |
US5314796A (en) | 1992-04-02 | 1994-05-24 | Konica Corporation | Silver halide color photographic light sensitive material |
US5387600A (en) | 1992-07-30 | 1995-02-07 | Fuji Photo Film Co., Ltd. | Treating arteriosclerosis using benzimidazole compositions |
DE4237617A1 (de) | 1992-11-06 | 1994-05-11 | Bayer Ag | Verwendung von substituierten Benzimidazolen |
DE4237557A1 (de) | 1992-11-06 | 1994-05-11 | Bayer Ag | Substituierte Benzimidazole |
JP3100984B2 (ja) | 1992-12-02 | 2000-10-23 | ファイザー・インク. | 選択的pde▲下i▼▲下v▼阻害物質としてのカテコールジエーテル類 |
DE69434016T2 (de) | 1993-03-04 | 2005-02-10 | Fuji Photo Film Co., Ltd., Minami-Ashigara | Photographisches Silberhalogenidmaterial |
DE4309969A1 (de) | 1993-03-26 | 1994-09-29 | Bayer Ag | Substituierte heteroanellierte Imidazole |
US6169107B1 (en) | 1993-04-28 | 2001-01-02 | Sumitomo Pharmaceutical Co., Ltd. | Indoloylguanidine derivatives |
JP3156444B2 (ja) | 1993-06-02 | 2001-04-16 | 松下電器産業株式会社 | 短波長レーザ光源およびその製造方法 |
DE4330959A1 (de) | 1993-09-09 | 1995-03-16 | Schering Ag | Neue Benzimidazolderivate, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung |
DE59509233D1 (de) | 1994-02-24 | 2001-06-13 | Haarmann & Reimer Gmbh | Kosmetische und dermatologische zubereitungen, enthaltend phenylen-1,4-bisbenzimidiazolesulfonsäuren |
CA2124169A1 (en) | 1994-05-24 | 1995-11-25 | Richard Mcculloch Keenan | Chemical compounds |
DE69530081T2 (de) | 1994-05-27 | 2003-12-24 | Black James Foundation | Gastrin- und cck-antagonisten |
PL181963B1 (pl) | 1994-11-29 | 2001-10-31 | Dainippon Pharmaceutical Co | Nowe pochodne indolu, kompozycja farmaceutyczna zawierajaca nowe pochodne indolu oraz sposób wytwarzania nowych pochodnych indolu PL PL PL |
EP0717143A1 (de) | 1994-12-16 | 1996-06-19 | Lignozym GmbH | Mehrkomponentensystem zum Verändern, Abbau oder Bleichen von Lignin, ligninhaltigen Materialien oder ähnlichen Stoffen sowie Verfahren zu seiner Anwendung |
DE19507913C2 (de) | 1995-03-07 | 1998-04-16 | Agfa Gevaert Ag | Farbfotografisches Silberhalogenidmaterial |
JPH11503445A (ja) | 1995-04-10 | 1999-03-26 | 藤沢薬品工業株式会社 | cGMP−PDE阻害剤としてのインドール誘導体 |
US6444694B1 (en) | 1995-06-06 | 2002-09-03 | Wyeth | Styryl benzimidazole derivatives |
JP3544245B2 (ja) | 1995-06-09 | 2004-07-21 | 富士写真フイルム株式会社 | ハロゲン化銀カラー写真感光材料の処理方法 |
KR100231956B1 (ko) | 1995-08-04 | 1999-12-01 | 오쯔까 유우지로 | 인돌-2-카복실산 에스테르 유도체 및 활성 성분으로서 이를 함유하는 농업용 및 원예용 살균제 |
AU6966696A (en) | 1995-10-05 | 1997-04-28 | Warner-Lambert Company | Method for treating and preventing inflammation and atherosclerosis |
PL190034B1 (pl) | 1995-10-05 | 2005-10-31 | Kyoto Pharmaceutical Ind | Nowe pochodne heterocykliczne i kompozycje farmaceutyczne zawierające nowe pochodne heterocykliczne |
JPH09124632A (ja) | 1995-10-31 | 1997-05-13 | Sankyo Co Ltd | ベンゾヘテロ環誘導体 |
CA2241186C (en) | 1995-12-28 | 2006-02-14 | Fujisawa Pharmaceutical Co., Ltd. | Benzimidazole derivatives |
GB9610811D0 (en) | 1996-05-23 | 1996-07-31 | Pharmacia Spa | Combinatorial solid phase synthesis of a library of indole derivatives |
JP4373497B2 (ja) | 1996-06-19 | 2009-11-25 | ローン−プーラン・ロレ・リミテツド | 置換されたアザビシクロ化合物、ならびにtnfおよびサイクリックampホスホジエステラーゼ産生の阻害剤としてのそれらの使用 |
GB9614347D0 (en) | 1996-07-09 | 1996-09-04 | Smithkline Beecham Spa | Novel compounds |
TR199900389T2 (xx) | 1996-08-28 | 2000-06-21 | Pfizer Inc. | �kame edilmi� 6,5-hetero-bisiklik t�revleri. |
WO1998029408A1 (fr) | 1996-12-26 | 1998-07-09 | Nikken Chemicals Co., Ltd. | Derives de n-hydroxyuree et compositions medicinales a base de ces derives |
PT968206E (pt) | 1997-02-19 | 2007-02-28 | Pharmacopeia Inc | Derivados n-heterocíclicos como inibidores de nos |
CA2279211A1 (en) | 1997-02-20 | 1998-08-27 | Shionogi & Co., Ltd. | Indole dicarboxylic acid derivatives |
AU757072B2 (en) | 1997-08-11 | 2003-01-30 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C inhibitor peptide analogues |
DE69829381T2 (de) | 1997-08-11 | 2006-04-13 | Boehringer Ingelheim (Canada) Ltd., Laval | Hepatitis c inhibitor peptide |
US5932743A (en) | 1997-08-21 | 1999-08-03 | American Home Products Corporation | Methods for the solid phase synthesis of substituted indole compounds |
DE19753522A1 (de) | 1997-12-03 | 1999-06-10 | Boehringer Ingelheim Pharma | Substituierte Indole, ihre Herstellung und ihre Verwendung als Arzneimittel |
SE9704544D0 (sv) | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
SE9704545D0 (sv) | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
HUP0102128A3 (en) | 1998-05-22 | 2002-05-28 | Avanir Pharmaceuticals San Die | Mediciaments containing benzimidazole derivatives as modulators of ige |
US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
ATE268327T1 (de) | 1998-06-18 | 2004-06-15 | Novartis Pharma Gmbh | Benzazol-verbindungen und ihre verwendung |
US7223879B2 (en) | 1998-07-10 | 2007-05-29 | Massachusetts Institute Of Technology | Ligands for metals and improved metal-catalyzed processes based thereon |
US6445525B1 (en) * | 1998-07-16 | 2002-09-03 | Seagate Technology Llc | Disc drive performance by reducing areal data storage density |
US6228868B1 (en) | 1998-07-27 | 2001-05-08 | Abbott Laboratories | Oxazoline antiproliferative agents |
ES2244204T3 (es) | 1998-07-27 | 2005-12-01 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Derivados de dicetoacidos como inhibidores de polimerasas. |
GB9816654D0 (en) | 1998-07-30 | 1998-09-30 | Zeneca Ltd | Chemical compounds |
AR022061A1 (es) | 1998-08-10 | 2002-09-04 | Boehringer Ingelheim Ca Ltd | Peptidos inhibidores de la hepatitis c, una composicion farmaceutica que los contiene, el uso de los mismos para preparar una composicion farmaceutica, el uso de un producto intermedio para la preparacion de estos peptidos y un procedimiento para la preparacion de un peptido analogo de los mismos. |
US6323180B1 (en) | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
ID27787A (id) | 1998-08-21 | 2001-04-26 | Viro Pharma Inc | Senyawa, komposisi dan metode untuk pengobatan atau pencegahan infeksi yang disebabkan oleh virus dan penyakit-penyakit yang berkaitan |
CA2343522A1 (en) | 1998-09-04 | 2000-03-16 | Viropharma Incorporated | Methods for treating or preventing viral infections and associated diseases |
WO2000018231A1 (en) | 1998-09-25 | 2000-04-06 | Viropharma Incorporated | Methods for treating or preventing viral infections and associated diseases |
GB9823871D0 (en) | 1998-10-30 | 1998-12-23 | Pharmacia & Upjohn Spa | 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents |
IL142893A0 (en) | 1998-11-12 | 2002-04-21 | Neurocrine Biosciences Inc | Fused polyclic heterocyclic compounds and pharmaceutical compositions containing the same |
US6531475B1 (en) | 1998-11-12 | 2003-03-11 | Neurocrine Biosciences, Inc. | CRF receptor antagonists and methods relating thereto |
US6358992B1 (en) | 1998-11-25 | 2002-03-19 | Cell Pathways, Inc. | Method of inhibiting neoplastic cells with indole derivatives |
WO2000039099A1 (fr) | 1998-12-24 | 2000-07-06 | Fujisawa Pharmaceutical Co., Ltd. | Derives de benzimidazole |
ATE241621T1 (de) | 1999-04-02 | 2003-06-15 | Bristol Myers Squibb Pharma Co | Arylsulfonyle als faktor xa inhibitoren |
UA74546C2 (en) | 1999-04-06 | 2006-01-16 | Boehringer Ingelheim Ca Ltd | Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition |
US6478874B1 (en) | 1999-08-06 | 2002-11-12 | Engelhard Corporation | System for catalytic coating of a substrate |
DE19951360A1 (de) | 1999-10-26 | 2001-05-03 | Aventis Pharma Gmbh | Substituierte Indole |
JP2001122855A (ja) | 1999-10-27 | 2001-05-08 | Japan Tobacco Inc | インドール化合物及びその医薬用途 |
ES2196926T3 (es) | 1999-10-28 | 2003-12-16 | Eoc Surfactants Nv | Procedimiento para la preparacion de disolucion concentrada fluida de betaina. |
CA2389745C (en) | 1999-11-04 | 2010-03-23 | Shire Biochem Inc. | Method for the treatment or prevention of flaviviridae viral infection using nucleoside analogues |
US6455525B1 (en) | 1999-11-04 | 2002-09-24 | Cephalon, Inc. | Heterocyclic substituted pyrazolones |
CA2395593C (en) | 1999-12-24 | 2011-08-02 | Aventis Pharma Limited | Azaindoles |
CN1623984A (zh) * | 1999-12-27 | 2005-06-08 | 日本烟草产业株式会社 | 稠环化合物及其药物用途 |
US6770666B2 (en) | 1999-12-27 | 2004-08-03 | Japan Tobacco Inc. | Fused-ring compounds and use thereof as drugs |
GB0003397D0 (en) | 2000-02-14 | 2000-04-05 | Merck Sharp & Dohme | Therapeutic agents |
AU2001235278A1 (en) | 2000-02-18 | 2001-08-27 | Shire Biochem Inc | Method for the treatment or prevention of flavivirus infections using nucleoside analogues |
US6727267B2 (en) | 2000-04-05 | 2004-04-27 | Tularik Inc. | NS5B HVC polymerase inhibitors |
JP2003532726A (ja) | 2000-05-05 | 2003-11-05 | スミスクライン・ビーチャム・コーポレイション | 新規抗感染症薬 |
AU2001261377A1 (en) | 2000-05-10 | 2001-11-20 | Smith Kline Beecham Corporation | Novel anti-infectives |
MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
KR100372218B1 (ko) | 2000-06-29 | 2003-02-14 | 바이오인포메틱스 주식회사 | 유기산을 생산하는 균주 및 이를 이용한 유기산의 생산방법 |
US6448281B1 (en) | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
GB0017676D0 (en) | 2000-07-19 | 2000-09-06 | Angeletti P Ist Richerche Bio | Inhibitors of viral polymerase |
US7244721B2 (en) | 2000-07-21 | 2007-07-17 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
US20030008841A1 (en) | 2000-08-30 | 2003-01-09 | Rene Devos | Anti-HCV nucleoside derivatives |
AU2001282528A1 (en) | 2000-09-01 | 2002-03-22 | Shionogi And Co., Ltd. | Compounds having anti-hepatitis c virus effect |
US6846806B2 (en) | 2000-10-23 | 2005-01-25 | Bristol-Myers Squibb Company | Peptide inhibitors of Hepatitis C virus NS3 protein |
ATE327246T1 (de) | 2000-11-20 | 2006-06-15 | Bristol Myers Squibb Co | Hepatitis c tripeptid inhibitoren |
EP1346724A4 (en) | 2000-12-26 | 2004-11-17 | Mitsubishi Pharma Corp | REMEDIES FOR HEPATITIS C |
JP3914156B2 (ja) | 2001-01-22 | 2007-05-16 | メルク エンド カムパニー インコーポレーテッド | Rna依存性rnaウィルスポリメラーゼ阻害薬としてのヌクレオシド誘導体 |
GB0102109D0 (en) | 2001-01-26 | 2001-03-14 | Syngenta Ltd | Chemical process |
AU2002252183A1 (en) | 2001-03-06 | 2002-09-19 | Biocryst Pharmaceuticals, Inc. | Nucleosides, preparation thereof and use as inhibitors of rna viral polymerases |
EP1370682A2 (en) | 2001-03-08 | 2003-12-17 | Boehringer Ingelheim (Canada) Ltd. | Assay for identifying inhibitors of the rna dependent rna polymerase (ns5b) of hcv |
KR100798579B1 (ko) | 2001-03-31 | 2008-01-28 | 동화약품공업주식회사 | 신규의 메톡시-1,3,5-트리아진 유도체 및 그를 포함하는약학적 조성물 |
EP1256628A3 (en) | 2001-05-10 | 2003-03-19 | Agouron Pharmaceuticals, Inc. | Hepatitis c virus (hcv) ns5b rna polymerase and mutants thereof |
GB0112617D0 (en) | 2001-05-23 | 2001-07-18 | Hoffmann La Roche | Antiviral nucleoside derivatives |
AR036081A1 (es) | 2001-06-07 | 2004-08-11 | Smithkline Beecham Corp | Compuesto de 1,2-dihidroquinolina, su uso para preparar una composicion farmaceutica, metodos para prepararlo y compuestos del acido 2-aminobenzoico n-alquilado de utilidad como intermediarios en dichos metodos |
US6887877B2 (en) | 2001-06-11 | 2005-05-03 | Virochem Pharma Inc. | Compounds and methods for the treatment or prevention of Flavivirus infections |
SK288015B6 (sk) | 2001-06-11 | 2012-11-05 | Virochem Pharma Inc. | Thiophene derivatives as antiviral agents for flavivirus infection |
GB0114286D0 (en) | 2001-06-12 | 2001-08-01 | Hoffmann La Roche | Nucleoside Derivatives |
GB0115109D0 (en) | 2001-06-21 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
JP2004534830A (ja) | 2001-06-21 | 2004-11-18 | グラクソ グループ リミテッド | Hcvにおけるヌクレオシド化合物 |
AR035543A1 (es) | 2001-06-26 | 2004-06-16 | Japan Tobacco Inc | Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con |
KR100713137B1 (ko) | 2001-06-28 | 2007-05-02 | 동화약품공업주식회사 | 신규의 2,4-디플루오로벤즈아미드 유도체 |
US6841566B2 (en) * | 2001-07-20 | 2005-01-11 | Boehringer Ingelheim, Ltd. | Viral polymerase inhibitors |
EP2335700A1 (en) * | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
US7294457B2 (en) | 2001-08-07 | 2007-11-13 | Boehringer Ingelheim (Canada) Ltd. | Direct binding assay for identifying inhibitors of HCV polymerase |
US20050032875A1 (en) | 2001-08-22 | 2005-02-10 | Heinz Wolleb | Process for the preparation of indole derivatives |
WO2003020222A2 (en) | 2001-09-04 | 2003-03-13 | Merck & Co., Inc. | PYRROLO[2,3-d]PYRIMIDINES FOR INHIBITING RNA-DEPENDENT RNA VIRAL POLYMERASE |
US20030134853A1 (en) | 2001-09-26 | 2003-07-17 | Priestley Eldon Scott | Compounds useful for treating hepatitis C virus |
AU2002330154A1 (en) | 2001-09-28 | 2003-04-07 | Centre National De La Recherche Scientifique | Methods and compositions for treating hepatitis c virus using 4'-modified nucleosides |
WO2003026675A1 (en) | 2001-09-28 | 2003-04-03 | Idenix (Cayman) Limited | Methods and compositions for treating flaviviruses and pestiviruses using 4'-modified nucleoside |
AU2002359320A1 (en) | 2001-10-29 | 2003-05-12 | Smithkline Beecham Corporation | Novel anit-infectives |
AU2002365198A1 (en) | 2001-10-30 | 2003-07-30 | Smithkline Beecham Corporation | Novel anti-infectives |
WO2003037894A1 (en) | 2001-11-02 | 2003-05-08 | Glaxo Group Limited | 4-(5-membered)-heteroaryl acyl pyrrolidine derivatives as hcv inhibitors |
US20050009873A1 (en) | 2001-11-02 | 2005-01-13 | Gianpaolo Bravi | Acyl dihydro pyrrole derivatives as hcv inhibitors |
MY151199A (en) | 2001-11-02 | 2014-04-30 | Rigel Pharmaceuticals Inc | Substituted diphenyl heterocycles useful for treating hcv infection |
DE60221875T2 (de) | 2001-11-02 | 2007-12-20 | Glaxo Group Ltd., Greenford | 4-(6-gliedrige)-heteroaryl-acyl-pyrrolidinderivate als hcv-inhibitoren |
WO2003042265A1 (fr) | 2001-11-13 | 2003-05-22 | Toray Industries, Inc. | Polymere et lentilles ophthalmologiques realisees a l'aide de ce polymere |
MXPA04004621A (es) | 2001-11-14 | 2004-09-10 | Biocryst Pharm Inc | Nucleotidos, preparaciones de los mismos y su utilizacion como inhibidores de polimerasas virales de arn. |
US6867185B2 (en) | 2001-12-20 | 2005-03-15 | Bristol-Myers Squibb Company | Inhibitors of hepatitis C virus |
US6936629B2 (en) | 2001-12-21 | 2005-08-30 | Virochem Pharma Inc. | Compounds and methods for the treatment or prevention of flavivirus infections |
WO2003062255A2 (en) | 2002-01-17 | 2003-07-31 | Ribapharm Inc. | Sugar modified nucleosides as viral replication inhibitors |
WO2003062256A1 (en) | 2002-01-17 | 2003-07-31 | Ribapharm Inc. | 2'-beta-modified-6-substituted adenosine analogs and their use as antiviral agents |
WO2003061385A1 (en) | 2002-01-17 | 2003-07-31 | Ribapharm Inc. | Tricyclic nucleoside library compounds, synthesis, and use as antiviral agents |
GB0201179D0 (en) | 2002-01-18 | 2002-03-06 | Angeletti P Ist Richerche Bio | Therapeutic agents |
CA2369711A1 (en) | 2002-01-30 | 2003-07-30 | Boehringer Ingelheim (Canada) Ltd. | Macrocyclic peptides active against the hepatitis c virus |
CA2370396A1 (en) | 2002-02-01 | 2003-08-01 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis c inhibitor tri-peptides |
CA2369970A1 (en) | 2002-02-01 | 2003-08-01 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis c inhibitor tri-peptides |
DE60307804T2 (de) | 2002-04-01 | 2007-01-18 | Pfizer Inc. | Pyranon- und pyrandioninhibitoren der rna-abhängigen rna-polymerase des hepatitis-c-virus |
KR100516434B1 (ko) | 2002-04-04 | 2005-09-22 | (주) 비엔씨바이오팜 | 6-(4-치환된-아닐리노)피리미딘 유도체, 그 제조방법 및 이를 포함하는 항바이러스용 약학적 조성물 |
AU2003237088A1 (en) | 2002-04-23 | 2003-11-10 | Viropharma Incorporated | Compounds, compositions and methods for treating or preventing viral infections and associated diseases |
US20040063658A1 (en) | 2002-05-06 | 2004-04-01 | Roberts Christopher Don | Nucleoside derivatives for treating hepatitis C virus infection |
DOP2003000641A (es) | 2002-05-10 | 2003-11-15 | Pfizer | Inhibidores de las arn polimerasa dependiente de arn del virus de las hepatitis c y composiciones y tratamiento que los usan |
GB0211418D0 (en) | 2002-05-17 | 2002-06-26 | Glaxo Group Ltd | Compounds |
JP4271148B2 (ja) | 2002-05-20 | 2009-06-03 | ブリストル−マイヤーズ スクイブ カンパニー | 置換シクロアルキルp1’c型肝炎ウイルスインヒビター |
ES2361011T3 (es) | 2002-05-20 | 2011-06-13 | Bristol-Myers Squibb Company | Inhibidores del virus de la hepatitis c. |
WO2003099316A1 (en) | 2002-05-20 | 2003-12-04 | Bristol-Myers Squibb Company | Heterocyclicsulfonamide hepatitis c virus inhibitors |
MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
TW200400818A (en) | 2002-05-21 | 2004-01-16 | Wyeth Corp | Method for the use of pyranoindole derivatives to treat infection with hepatitis C virus |
TW200400963A (en) | 2002-05-21 | 2004-01-16 | Wyeth Corp | R-enantiomers of pyranoindole derivatives and the use thereof for the treatment of hepatitis C virus infection or disease |
WO2003099801A1 (en) | 2002-05-24 | 2003-12-04 | Smithkline Beecham Corporation | Novel anti-infectives |
ATE389656T1 (de) | 2002-06-04 | 2008-04-15 | Neogenesis Pharmaceuticals Inc | Pyrazolo(1,5-a)pyrimidin-verbindungen als antivirale agentien |
JP2005533777A (ja) | 2002-06-17 | 2005-11-10 | メルク エンド カムパニー インコーポレーテッド | Rna抗ウイルス剤としての炭素環ヌクレオシドアナログ |
CA2489573A1 (en) | 2002-06-25 | 2003-12-31 | Cosmeceutic Solutions Pty Ltd | Topical cosmetic compositions |
AU2003269892A1 (en) | 2002-06-27 | 2004-01-19 | Isis Pharmaceuticals, Inc. | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
RS113904A (en) | 2002-06-28 | 2007-02-05 | Idenix (Cayman) Limited | 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
PL374831A1 (en) | 2002-06-28 | 2005-10-31 | Idenix (Cayman) Limited | Modified 2' and 3' -nucleoside prodrugs for treating flaviridae infections |
JP5087211B2 (ja) | 2002-06-28 | 2012-12-05 | イデニクス(ケイマン)リミテツド | フラビウィルス感染治療のための2′および3′−ヌクレオシドプロドラッグ |
JP2006504643A (ja) | 2002-07-01 | 2006-02-09 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | Hcvns5bポリメラーゼ阻害剤 |
WO2004002940A1 (en) | 2002-07-01 | 2004-01-08 | Pharmacia & Upjohn Company | Inhibitors of hcv ns5b polymerase |
GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
AU2003269902A1 (en) | 2002-07-16 | 2004-02-02 | Isis Pharmaceuticals, Inc. | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
US20050075279A1 (en) | 2002-10-25 | 2005-04-07 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
US7098231B2 (en) * | 2003-01-22 | 2006-08-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US7223785B2 (en) | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
JP2007524576A (ja) | 2003-02-07 | 2007-08-30 | エナンタ ファーマシューティカルズ インコーポレイテッド | 大環状のc型肝炎セリンプロテアーゼ阻害剤 |
EP1601685A1 (en) | 2003-03-05 | 2005-12-07 | Boehringer Ingelheim International GmbH | Hepatitis c inhibiting compounds |
ES2354282T3 (es) | 2003-03-05 | 2011-03-11 | Boehringer Ingelheim International Gmbh | Análogos peptídicos inhibidores de la hepatitis c. |
GB0307891D0 (en) * | 2003-04-04 | 2003-05-14 | Angeletti P Ist Richerche Bio | Chemical compounds,compositions and uses |
ATE422895T1 (de) | 2003-04-16 | 2009-03-15 | Bristol Myers Squibb Co | Makrocyclische isochinolinpeptidinhibitoren des hepatitis-c-virus |
DK1615613T3 (da) | 2003-04-18 | 2010-03-22 | Enanta Pharm Inc | Quinoxalinyl-makrocykliske hepatitis C serin protease-inhibitorer |
OA13164A (en) | 2003-05-12 | 2006-12-13 | Affymax Inc | Novel peptides that bind to the erythropoietin receptor. |
AU2004240704B9 (en) | 2003-05-21 | 2009-10-22 | Boehringer Ingelheim International Gmbh | Hepatitis C inhibitor compounds |
EP1493440A1 (en) * | 2003-07-03 | 2005-01-05 | Rinoru Oil Mills Co., Ltd. | Prophylactic agent of hypertension containing a conjugated fatty acid as an effective ingredient and the use thereof |
AU2004261667A1 (en) | 2003-08-01 | 2005-02-10 | Genelabs Technologies, Inc. | Bicyclic imidazol derivatives against Flaviviridae |
WO2005014543A1 (ja) | 2003-08-06 | 2005-02-17 | Japan Tobacco Inc. | 縮合環化合物及びそのhcvポリメラーゼ阻害剤としての利用 |
ES2431314T3 (es) * | 2004-02-20 | 2013-11-26 | Boehringer Ingelheim International Gmbh | Inhibidores de polimerasa vírica |
NZ550177A (en) | 2004-03-08 | 2010-08-27 | Boehringer Ingelheim Pharma | Process for cross coupling indoles |
US7126009B2 (en) | 2004-03-16 | 2006-10-24 | Boehringer Ingelheim International, Gmbh | Palladium catalyzed indolization of 2-bromo or chloroanilines |
UY29017A1 (es) | 2004-07-16 | 2006-02-24 | Boehringer Ingelheim Int | Inhibidores de polimerasa viral |
KR20070112165A (ko) | 2005-02-11 | 2007-11-22 | 베링거 인겔하임 인터내셔날 게엠베하 | 2,3-이치환된 인돌의 제조방법 |
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