|
PA8474101A1
(es)
|
1998-06-19 |
2000-09-29 |
Pfizer Prod Inc |
Compuestos de pirrolo [2,3-d] pirimidina
|
|
EP1065207A1
(en)
*
|
1999-07-02 |
2001-01-03 |
Aventis Pharma Deutschland GmbH |
Naphthyridine derivatives, processes for their preparation, their use, and pharmaceutical compositions comprising them
|
|
DE19948417A1
(de)
*
|
1999-10-07 |
2001-04-19 |
Morphochem Ag |
Imidazol-Derivate und ihre Verwendung als Arzneimittel
|
|
AU770600B2
(en)
|
1999-10-07 |
2004-02-26 |
Amgen, Inc. |
Triazine kinase inhibitors
|
|
AP1905A
(en)
|
1999-12-10 |
2008-10-20 |
Pfizer Prod Inc |
Pyrrolo[2,3-d] Pyrimidine Compounds.
|
|
EP1250137B1
(en)
*
|
2000-01-24 |
2007-08-15 |
Genzyme Corporation |
Jak/stat pathway inhibitors and the use thereof for the treatment of primary generalized osteoarthritis
|
|
EP1782800B1
(en)
*
|
2000-01-24 |
2013-12-18 |
Genzyme Corporation |
Methods for detecting JAK3 inhibitors
|
|
MY145722A
(en)
*
|
2000-04-27 |
2012-03-30 |
Abbott Lab |
Diazabicyclic central nervous system active agents
|
|
CA2412560C
(en)
*
|
2000-06-26 |
2008-12-30 |
Pfizer Products Inc. |
Pyrrolo[2,3-d]pyrimidine compounds as immunosuppressive agents
|
|
US6864255B2
(en)
|
2001-04-11 |
2005-03-08 |
Amgen Inc. |
Substituted triazinyl amide derivatives and methods of use
|
|
US6881737B2
(en)
|
2001-04-11 |
2005-04-19 |
Amgen Inc. |
Substituted triazinyl acrylamide derivatives and methods of use
|
|
US7301023B2
(en)
*
|
2001-05-31 |
2007-11-27 |
Pfizer Inc. |
Chiral salt resolution
|
|
KR100875380B1
(ko)
*
|
2001-06-23 |
2008-12-23 |
아벤티스 파마슈티칼스 인크. |
단백질 키나제 억제제로서의 피롤로피리미딘
|
|
GB0115393D0
(en)
*
|
2001-06-23 |
2001-08-15 |
Aventis Pharma Ltd |
Chemical compounds
|
|
US7323469B2
(en)
|
2001-08-07 |
2008-01-29 |
Novartis Ag |
7H-pyrrolo[2,3-d]pyrimidine derivatives
|
|
GB0119249D0
(en)
|
2001-08-07 |
2001-10-03 |
Novartis Ag |
Organic compounds
|
|
GT200200234A
(es)
|
2001-12-06 |
2003-06-27 |
|
Compuestos cristalinos novedosos
|
|
US6642381B2
(en)
*
|
2001-12-27 |
2003-11-04 |
Hoffman-La Roche Inc. |
Pyrimido[5,4-e][1,2,4]triazine-5,7-diamine compounds as protein tyrosine phosphatase inhibitors
|
|
BR0306785A
(pt)
|
2002-01-07 |
2004-11-09 |
Eisai Co Ltd |
Deazapurinas e seus usos
|
|
GB0202679D0
(en)
*
|
2002-02-05 |
2002-03-20 |
Glaxo Group Ltd |
Novel compounds
|
|
EP1388541A1
(en)
|
2002-08-09 |
2004-02-11 |
Centre National De La Recherche Scientifique (Cnrs) |
Pyrrolopyrazines as kinase inhibitors
|
|
NZ539901A
(en)
|
2002-11-26 |
2007-09-28 |
Pfizer Prod Inc |
Method of treatment of transplant rejection
|
|
WO2004093812A2
(en)
*
|
2003-04-22 |
2004-11-04 |
Irm Llc |
Compounds that induce neuronal differentiation in embryonic stem cells
|
|
CA2543116A1
(en)
*
|
2003-10-27 |
2005-05-19 |
Genelabs Technologies, Inc. |
Methods for preparing 7-(2'-substituted-.szlig.-d-ribofuranosyl)-4-(nr2r3)-5-(substituted ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine derivatives
|
|
US20050187389A1
(en)
*
|
2004-01-13 |
2005-08-25 |
Ambit Biosciences Corporation |
Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases
|
|
GB0403606D0
(en)
|
2004-02-18 |
2004-03-24 |
Novartis Ag |
Organic compounds
|
|
CA2563699C
(en)
*
|
2004-04-23 |
2014-03-25 |
Exelixis, Inc. |
Kinase modulators and method of use
|
|
EP2583678A3
(en)
|
2004-06-24 |
2013-11-13 |
Novartis Vaccines and Diagnostics, Inc. |
Small molecule immunopotentiators and assays for their detection
|
|
MXPA06015237A
(es)
|
2004-06-29 |
2007-12-10 |
Amgen Inc |
Pirrolo[2-3-d]pirimidinas que modulan la actividad de ack1 y lck.
|
|
EP1797054A2
(en)
|
2004-08-02 |
2007-06-20 |
OSI Pharmaceuticals, Inc. |
Aryl-amino substituted pyrrolopyrimidine multi-kinase inhibiting compounds
|
|
MY179032A
(en)
|
2004-10-25 |
2020-10-26 |
Cancer Research Tech Ltd |
Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
|
|
UY29177A1
(es)
|
2004-10-25 |
2006-05-31 |
Astex Therapeutics Ltd |
Derivados sustituidos de purina, purinona y deazapurina, composiciones que los contienen métodos para su preparación y sus usos
|
|
AR054416A1
(es)
|
2004-12-22 |
2007-06-27 |
Incyte Corp |
Pirrolo [2,3-b]piridin-4-il-aminas y pirrolo [2,3-b]pirimidin-4-il-aminas como inhibidores de las quinasas janus. composiciones farmaceuticas.
|
|
FR2880626B1
(fr)
*
|
2005-01-13 |
2008-04-18 |
Aventis Pharma Sa |
Derives de la purine, compositions les contenant et utilisation
|
|
WO2006091450A1
(en)
*
|
2005-02-18 |
2006-08-31 |
Lexicon Genetics Incorporated |
4-piperidin-1-yl-7h-pyrrolo[2,3-d]pyrimidine compounds
|
|
DE602006019088D1
(de)
|
2005-05-13 |
2011-02-03 |
Irm Llc |
Verbindungen und zusammensetzungen als proteinkinase-hemmer
|
|
EP2251341A1
(en)
|
2005-07-14 |
2010-11-17 |
Astellas Pharma Inc. |
Heterocyclic Janus kinase 3 inhibitors
|
|
WO2007007919A2
(en)
|
2005-07-14 |
2007-01-18 |
Astellas Pharma Inc. |
Heterocyclic janus kinase 3 inhibitors
|
|
CA2621261C
(en)
|
2005-09-22 |
2014-05-20 |
Incyte Corporation |
Azepine inhibitors of janus kinases
|
|
RU2008117151A
(ru)
*
|
2005-09-30 |
2009-11-10 |
Вертекс Фармасьютикалз Инкорпорейтед (Us) |
Деазапурины, пригодные в качестве ингибиторов янус-киназ
|
|
AU2015201850B2
(en)
*
|
2005-12-13 |
2017-03-02 |
Incyte Holdings Corporation |
Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors
|
|
EP3184526B1
(en)
|
2005-12-13 |
2018-10-03 |
Incyte Holdings Corporation |
Pyrrolo[2,3-d]pyrimidine derivatives as janus kinase inhibitor
|
|
JP2009533323A
(ja)
*
|
2006-03-11 |
2009-09-17 |
ヴァーナリス アールアンドディー リミテッド |
Hsp90阻害剤として用いられるピロロピリミジン誘導体
|
|
EP2001884A1
(en)
|
2006-04-05 |
2008-12-17 |
Vertex Pharmaceuticals, Inc. |
Deazapurines useful as inhibitors of janus kinases
|
|
GB0608176D0
(en)
*
|
2006-04-25 |
2006-06-07 |
Astex Therapeutics Ltd |
Pharmaceutical Compounds
|
|
EP2043655A2
(en)
*
|
2006-04-25 |
2009-04-08 |
Astex Therapeutics Limited |
Purine and deazapurine derivatives as pharmaceutical compounds
|
|
WO2008012635A2
(en)
*
|
2006-07-26 |
2008-01-31 |
Pfizer Products Inc. |
Amine derivatives useful as anticancer agents
|
|
KR20090077914A
(ko)
*
|
2006-09-11 |
2009-07-16 |
쿠리스 인코퍼레이션 |
항증식제로서의 다작용성 소분자
|
|
US20080161320A1
(en)
*
|
2006-09-11 |
2008-07-03 |
Xiong Cai |
Fused bicyclic pyrimidines as ptk inhibitors containing a zinc binding moiety
|
|
WO2008075007A1
(en)
*
|
2006-12-21 |
2008-06-26 |
Cancer Research Technology Limited |
Morpholino-substituted bicycloheteroaryl compounds and their use as anti cancer agents
|
|
AR064416A1
(es)
*
|
2006-12-21 |
2009-04-01 |
Cancer Rec Tech Ltd |
Derivados de purina, piridina y pirimidina condensadas con heterociclos, moduladores de pka y/o pkb, composiciones farmaceuticas que los contienen, y usos para el tratamiento de enfermedades hiperproliferativas.
|
|
ES2415863T3
(es)
|
2006-12-22 |
2013-07-29 |
Incyte Corporation |
Heterociclos sustituidos como inhibidores de Janus Quinasas
|
|
KR20090106604A
(ko)
|
2007-01-12 |
2009-10-09 |
아스텔라스세이야쿠 가부시키가이샤 |
축합 피리딘 화합물
|
|
PE20090996A1
(es)
*
|
2007-04-02 |
2009-07-15 |
Palau Pharma Sa |
Derivados de pirrolopirimidina como inhibidores de cinasa jak3
|
|
UA99284C2
(ru)
|
2007-05-11 |
2012-08-10 |
Елі Ліллі Енд Компані |
ИНГИБИТОРЫ р70 S6-КИНАЗЫ
|
|
CL2008001709A1
(es)
|
2007-06-13 |
2008-11-03 |
Incyte Corp |
Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
|
|
MX342814B
(es)
|
2007-06-13 |
2016-10-13 |
Incyte Holdings Corp |
Sales de inhibidor de janus cinasa (r)-3-(4-7h-pirrolo[2,3-d]pirim idin-4-il)-1h-pirazol-1-il)-3-ciclopentilpropanitrilo.
|
|
GB0713602D0
(en)
*
|
2007-07-12 |
2007-08-22 |
Syngenta Participations Ag |
Chemical compounds
|
|
US8318731B2
(en)
*
|
2007-07-27 |
2012-11-27 |
Janssen Pharmaceutica Nv |
Pyrrolopyrimidines
|
|
ES2557931T3
(es)
|
2007-08-08 |
2016-01-29 |
Lexicon Pharmaceuticals, Inc. |
(7H-Pirrolo[2,3-d]pirimidin-4-il)-piperazinas como inhibidores de cinasas para el tratamiento de cáncer e inflamación
|
|
WO2009030871A1
(en)
*
|
2007-09-07 |
2009-03-12 |
Vernalis R & D Ltd |
Pyrrolopyrimidine derivatives having hsp90 inhibitory activity
|
|
NZ585261A
(en)
|
2007-10-11 |
2011-10-28 |
Astrazeneca Ab |
Pyrrolo [2, 3 -d] pyrimidin derivatives as protein kinase b inhibitors
|
|
EP2220068B1
(en)
|
2007-11-16 |
2016-01-27 |
Incyte Holdings Corporation |
4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as janus kinase inhibitors
|
|
RS55263B1
(sr)
|
2008-03-11 |
2017-02-28 |
Incyte Holdings Corp |
Derivati azetidina i ciklobutana kao jak inhibitori
|
|
AU2009239500B2
(en)
|
2008-04-21 |
2014-01-30 |
Lexicon Pharmaceuticals, Inc. |
LIMK2 inhibitors, compositions comprising them, and methods of their use
|
|
CA2722326A1
(en)
|
2008-04-24 |
2009-10-29 |
Incyte Corporation |
Macrocyclic compounds and their use as kinase inhibitors
|
|
CN102131812B
(zh)
|
2008-08-20 |
2014-04-09 |
硕腾有限责任公司 |
吡咯并[2,3-d]嘧啶化合物
|
|
US8385364B2
(en)
*
|
2008-09-24 |
2013-02-26 |
Nec Laboratories America, Inc. |
Distributed message-passing based resource allocation in wireless systems
|
|
CL2009001884A1
(es)
*
|
2008-10-02 |
2010-05-14 |
Incyte Holdings Corp |
Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco.
|
|
JOP20190230A1
(ar)
|
2009-01-15 |
2017-06-16 |
Incyte Corp |
طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به
|
|
DE102009005193A1
(de)
*
|
2009-01-20 |
2010-07-22 |
Merck Patent Gmbh |
Neue heterocyclische Verbindungen als MetAP-2 Inhibitoren
|
|
US8765727B2
(en)
|
2009-01-23 |
2014-07-01 |
Incyte Corporation |
Macrocyclic compounds and their use as kinase inhibitors
|
|
EP2396004A4
(en)
|
2009-02-11 |
2012-07-25 |
Reaction Biology Corp |
SELECTIVE KINASE HEMMER
|
|
CA2759026C
(en)
|
2009-04-20 |
2019-01-15 |
Auspex Pharmaceuticals, Inc. |
Piperidine inhibitors of janus kinase 3
|
|
MX2011012353A
(es)
|
2009-05-22 |
2011-12-14 |
Incyte Corp |
Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo[2, 3-d]pirimidinas y pirrol-3-il-pirrolo[2,3-d]pirimidinas como inhibidores de la cinasa janus.
|
|
SG10201402492TA
(en)
|
2009-05-22 |
2014-08-28 |
Incyte Corp |
Use of jak inhibitors 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile
|
|
CN102574857B
(zh)
*
|
2009-07-08 |
2015-06-10 |
利奥制药有限公司 |
作为jak受体和蛋白酪氨酸激酶抑制剂的杂环化合物
|
|
TWI466885B
(zh)
*
|
2009-07-31 |
2015-01-01 |
Japan Tobacco Inc |
含氮螺環化合物及其醫藥用途
|
|
TW201111385A
(en)
*
|
2009-08-27 |
2011-04-01 |
Biocryst Pharm Inc |
Heterocyclic compounds as janus kinase inhibitors
|
|
TW201113285A
(en)
|
2009-09-01 |
2011-04-16 |
Incyte Corp |
Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
|
|
EP2473054B1
(en)
*
|
2009-09-04 |
2017-06-14 |
The Regents of the University of Michigan |
Compositions and methods for treatment of leukemia
|
|
JP5699149B2
(ja)
|
2009-09-04 |
2015-04-08 |
バイオジェン・アイデック・エムエイ・インコーポレイテッド |
Bruton型チロシンキナーゼ阻害薬
|
|
JP5946768B2
(ja)
|
2009-10-09 |
2016-07-06 |
インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation |
3−(4−(7H−ピロロ[2,3−d]ピリミジン−4−イル)−1H−ピラゾール−1−イル)−3−シクロペンチルプロパンニトリルのヒドロキシル、ケト及びグルクロニド誘導体
|
|
MX2012004379A
(es)
|
2009-10-15 |
2012-06-01 |
Pfizer |
Compuestos de pirrolo[2,3-d]pirimidina.
|
|
US9074143B2
(en)
*
|
2009-12-11 |
2015-07-07 |
Uop Llc |
Process for producing hydrocarbon fuel
|
|
JP5739446B2
(ja)
|
2009-12-18 |
2015-06-24 |
ファイザー・インク |
ピロロ[2,3−d]ピリミジン化合物
|
|
AU2011213198B2
(en)
|
2010-02-05 |
2014-04-24 |
Zoetis Llc |
Pyrrolo [ 2,3-d] pyrimidine urea compounds as JAK inhibitors
|
|
WO2011103423A1
(en)
*
|
2010-02-18 |
2011-08-25 |
Incyte Corporation |
Cyclobutane and methylcyclobutane derivatives as janus kinase inhibitors
|
|
TWI643857B
(zh)
|
2010-03-10 |
2018-12-11 |
英塞特公司 |
作為jak1抑制劑之哌啶-4-基三亞甲亞胺衍生物
|
|
HUE029035T2
(en)
|
2010-05-21 |
2017-01-30 |
Incyte Holdings Corp |
Topical formulation for a jak inhibitor
|
|
CN102985425A
(zh)
*
|
2010-07-09 |
2013-03-20 |
利奥制药有限公司 |
作为蛋白酪氨酸激酶抑制剂的新的高哌嗪衍生物及其医药用途
|
|
WO2012022045A1
(en)
*
|
2010-08-20 |
2012-02-23 |
Hutchison Medipharma Limited |
Pyrrolopyrimidine compounds and uses thereof
|
|
CN102372717B
(zh)
*
|
2010-08-20 |
2014-06-18 |
和记黄埔医药(上海)有限公司 |
吡咯并嘧啶类化合物及其用途
|
|
RU2563644C2
(ru)
|
2010-08-20 |
2015-09-20 |
Хатчисон Медифарма Лимитед |
Пирролопиримидиновые соединения и их применения
|
|
TWI401258B
(zh)
*
|
2010-09-08 |
2013-07-11 |
Hutchison Medipharma Ltd |
吡咯並嘧啶類化合物及其用途
|
|
WO2012068440A1
(en)
|
2010-11-19 |
2012-05-24 |
Incyte Corporation |
Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors
|
|
UA113156C2
(xx)
|
2010-11-19 |
2016-12-26 |
|
Циклобутилзаміщені похідні піролопіридину й піролопіримідину як інгібітори jak
|
|
ES2617339T3
(es)
|
2010-12-16 |
2017-06-16 |
Calchan Limited |
Derivados de pirrolopirimidina inhibidores de ASK1
|
|
WO2012088682A1
(en)
*
|
2010-12-29 |
2012-07-05 |
Shanghai Fochon Pharmaceutical Co Ltd. |
2-(3-aminopiperidin-1-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-5,7(3h,6h)-dione derivates as dipeptidyl peptidase iv(dpp-iv) inhibitors
|
|
MX2013007792A
(es)
*
|
2011-01-07 |
2013-07-30 |
Leo Pharma As |
Nuevos derivados de sulfamida piperazina como inhibidores de proteina tirosina cinasa y uso farmaceutico de los mismos.
|
|
DE102011008352A1
(de)
*
|
2011-01-12 |
2012-07-12 |
Merck Patent Gmbh |
5-([1,2,3]Triazol-4-yl)-7H-pyrrolo-[2,3-d]pyrimidinderivate
|
|
CA2826295C
(en)
*
|
2011-02-04 |
2020-10-20 |
Duquesne University Of The Holy Spirit |
Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity and methods of treating a patient
|
|
EP2675451B9
(en)
|
2011-02-18 |
2017-07-26 |
Novartis Pharma AG |
mTOR/JAK INHIBITOR COMBINATION THERAPY
|
|
BR112013024267A2
(pt)
|
2011-03-22 |
2018-06-26 |
Advinus Therapeutics Ltd |
compostos tricíclicos fundidos substituídos, composições e aplicações medicinais dos mesmos.
|
|
SMT201900725T1
(it)
|
2011-04-01 |
2020-01-14 |
Astrazeneca Ab |
Trattamento terapeutico
|
|
MX344479B
(es)
|
2011-06-20 |
2016-12-16 |
Incyte Holdings Corp |
Derivados de azetidinil fenil, piridil o pirazinil carboxamida como inhibidores de cinasa janus (jak).
|
|
JP2014518266A
(ja)
*
|
2011-06-29 |
2014-07-28 |
メルク・シャープ・アンド・ドーム・コーポレーション |
ジペプチジルペプチダーゼ−iv阻害剤の新規結晶形
|
|
EP2729466B1
(en)
|
2011-07-08 |
2015-08-19 |
Novartis AG |
Novel pyrrolo pyrimidine derivatives
|
|
US9358229B2
(en)
|
2011-08-10 |
2016-06-07 |
Novartis Pharma Ag |
JAK PI3K/mTOR combination therapy
|
|
TW201313721A
(zh)
|
2011-08-18 |
2013-04-01 |
Incyte Corp |
作為jak抑制劑之環己基氮雜環丁烷衍生物
|
|
UA111854C2
(uk)
|
2011-09-07 |
2016-06-24 |
Інсайт Холдінгс Корпорейшн |
Способи і проміжні сполуки для отримання інгібіторів jak
|
|
EP3750544B1
(en)
|
2011-11-30 |
2025-03-05 |
Emory University |
Jak inhibitors for use in the prevention or treatment of a viral disease caused by a coronaviridae
|
|
PT2785349T
(pt)
|
2011-11-30 |
2019-12-11 |
Astrazeneca Ab |
Tratamento combinado de cancro
|
|
EP2788000B1
(en)
*
|
2011-12-06 |
2018-05-30 |
Merck Sharp & Dohme Corp. |
Pyrrolopyrimidines as janus kinase inhibitors
|
|
AU2013204533B2
(en)
|
2012-04-17 |
2017-02-02 |
Astrazeneca Ab |
Crystalline forms
|
|
AR091079A1
(es)
|
2012-05-18 |
2014-12-30 |
Incyte Corp |
Derivados de pirrolopirimidina y pirrolopiridina sustituida con piperidinilciclobutilo como inhibidores de jak
|
|
AR091273A1
(es)
|
2012-06-08 |
2015-01-21 |
Biogen Idec Inc |
Inhibidores de pirimidinil tirosina quinasa
|
|
ES2637245T3
(es)
|
2012-06-29 |
2017-10-11 |
Pfizer Inc. |
Nuevas 4-(amino sustituido)-7H-pirrolo[2,3-d]pirimidinas como inhibidores de LRRK2
|
|
AU2013312477B2
(en)
*
|
2012-09-06 |
2018-05-31 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
JP2015529242A
(ja)
|
2012-09-21 |
2015-10-05 |
アドヴィヌス セラピューティクス リミテッドAdvinus Therapeutics Limited |
置換された縮合三環式化合物、組成物およびその医薬用途
|
|
KR20150060839A
(ko)
*
|
2012-10-26 |
2015-06-03 |
에프. 호프만-라 로슈 아게 |
브루톤 티로신 키나아제의 억제제
|
|
CN102936251A
(zh)
*
|
2012-11-05 |
2013-02-20 |
上海毕得医药科技有限公司 |
一种吡咯并[2,3-d]嘧啶衍生物的制备方法
|
|
NZ708157A
(en)
|
2012-11-15 |
2019-07-26 |
Incyte Holdings Corp |
Sustained-release dosage forms of ruxolitinib
|
|
HUE037192T2
(hu)
|
2013-02-22 |
2018-08-28 |
Pfizer |
Pirrolo [2,3-D]pirimidin származékok mint a Janus-kinázok (JAK) inhibitorai
|
|
PE20200298A1
(es)
|
2013-03-06 |
2020-02-06 |
Incyte Holdings Corp |
Procesos e intermedios para hacer un inhibidor de jak
|
|
WO2014139388A1
(en)
*
|
2013-03-14 |
2014-09-18 |
Merck Sharp & Dohme Corp. |
Novel indole derivatives useful as anti-diabetic agents
|
|
CN105579032A
(zh)
|
2013-08-07 |
2016-05-11 |
因赛特公司 |
Jak1抑制剂的持续释放剂型
|
|
MY187446A
(en)
|
2013-12-05 |
2021-09-22 |
Pfizer |
Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl and pyrrolo[2,3-d]pyridinyl acrylamides
|
|
EP3083618B1
(en)
|
2013-12-17 |
2018-02-21 |
Pfizer Inc |
Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors
|
|
US9498467B2
(en)
|
2014-05-30 |
2016-11-22 |
Incyte Corporation |
Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1
|
|
EP3180344B1
(en)
|
2014-08-12 |
2019-09-18 |
Pfizer Inc |
Pyrrolo[2,3-d]pyrimidine derivatives useful for inhibiting janus kinase
|
|
US10246464B2
(en)
|
2014-09-09 |
2019-04-02 |
The Regents Of The University Of Michigan |
Thienopyrimidine and thienopyridine compounds and methods of use thereof
|
|
CN105524067A
(zh)
*
|
2014-09-28 |
2016-04-27 |
江苏柯菲平医药股份有限公司 |
4-取代吡咯并[2,3-d]嘧啶化合物及其用途
|
|
EP3288943B1
(en)
|
2015-05-01 |
2022-09-28 |
Pfizer Inc. |
Pyrrolo[2,3-b]pyrazinyl acrylamides and epoxides thereof as inhibitors of janus kinase
|
|
WO2016197027A1
(en)
|
2015-06-04 |
2016-12-08 |
Kura Oncology, Inc. |
Methods and compositions for inhibiting the interaction of menin with mll proteins
|
|
AR104020A1
(es)
|
2015-06-04 |
2017-06-21 |
Kura Oncology Inc |
Métodos y composiciones para inhibir la interacción de menina con proteínas mill
|
|
US10421760B2
(en)
|
2015-07-31 |
2019-09-24 |
Taiho Pharmaceutical Co., Ltd. |
Pyrrolo[2,3-d]pyrimidine compound or salt thereof
|
|
KR101771219B1
(ko)
*
|
2015-08-21 |
2017-09-05 |
양지화학 주식회사 |
야누스 키나제 1 선택적 억제제 및 그 의약 용도
|
|
RU2722149C1
(ru)
|
2015-09-14 |
2020-05-27 |
Пфайзер Инк. |
Новые производные имидазо[4,5-c] хинолинов и имидазо[4,5-c][1,5] нафтиридинов в качестве ингибиторов LRRK2
|
|
WO2017091681A1
(en)
|
2015-11-24 |
2017-06-01 |
Aclaris Therapeutics, Inc. |
Selective kinase inhibitors
|
|
CN107098908B
(zh)
*
|
2016-02-23 |
2021-01-08 |
欣凯医药科技(上海)有限公司 |
一种吡咯并嘧啶类化合物的制备方法和应用
|
|
SG11201807834WA
(en)
|
2016-03-16 |
2018-10-30 |
Kura Oncology Inc |
Bridged bicyclic inhibitors of menin-mll and methods of use
|
|
LT3429591T
(lt)
|
2016-03-16 |
2023-07-10 |
Kura Oncology, Inc. |
Pakeistojo tieno[2,3-d]pirimidino dariniai kaip menino-mll inhibitoriai ir jų panaudojimo būdai
|
|
CN107513069A
(zh)
|
2016-06-16 |
2017-12-26 |
正大天晴药业集团股份有限公司 |
手性吡咯并嘧啶化合物的制备方法
|
|
CN107513067A
(zh)
|
2016-06-16 |
2017-12-26 |
北京赛林泰医药技术有限公司 |
含有取代环戊基的吡咯并嘧啶化合物
|
|
CN110049976A
(zh)
|
2016-07-21 |
2019-07-23 |
比奥根Ma公司 |
布鲁顿氏酪氨酸激酶抑制剂的琥珀酸盐形式和组合物
|
|
WO2018140648A1
(en)
|
2017-01-25 |
2018-08-02 |
Eric Jon Jacobsen |
Pyrrolopyrimidine itk inhibitors for treating inflammation and cancer
|
|
RU2761626C2
(ru)
*
|
2017-02-03 |
2021-12-13 |
Лео Фарма А/С |
ПРОИЗВОДНЫЕ 5-(7Н-ПИРРОЛО[2,3-d]ПИРИМИДИН-4-ИЛ)-5-АЗАСПИРО[2.5]ОКТАН-8-КАРБОНОВОЙ КИСЛОТЫ В КАЧЕСТВЕ НОВЫХ ИНГИБИТОРОВ JAK-КИНАЗЫ
|
|
CN110691779B
(zh)
|
2017-03-24 |
2023-10-10 |
库拉肿瘤学公司 |
治疗血液系统恶性肿瘤和尤因肉瘤的方法
|
|
CN108794480A
(zh)
*
|
2017-04-28 |
2018-11-13 |
天津药物研究院有限公司 |
吡咯并嘧啶类化合物、其制备方法和用途
|
|
US11542248B2
(en)
|
2017-06-08 |
2023-01-03 |
Kura Oncology, Inc. |
Methods and compositions for inhibiting the interaction of menin with MLL proteins
|
|
WO2019060365A1
(en)
|
2017-09-20 |
2019-03-28 |
Kura Oncology, Inc. |
SUBSTITUTED MÉNINE-MLL INHIBITORS AND METHODS OF USE
|
|
US10800775B2
(en)
|
2017-11-03 |
2020-10-13 |
Aclaris Therapeutics, Inc. |
Pyrazolyl pyrrolo[2,3-b]pyrmidine-5-carboxylate analogs and methods of making the same
|
|
BR112020008850A2
(pt)
|
2017-11-03 |
2020-10-20 |
Aclaris Therapeutics, Inc. |
composto, composição farmacêutica e método para tratar uma doença mediada por jak1 e jak3
|
|
WO2019113487A1
(en)
|
2017-12-08 |
2019-06-13 |
Incyte Corporation |
Low dose combination therapy for treatment of myeloproliferative neoplasms
|
|
AR114810A1
(es)
|
2018-01-30 |
2020-10-21 |
Incyte Corp |
Procesos e intermedios para elaborar un inhibidor de jak
|
|
JP7720697B2
(ja)
|
2018-03-30 |
2025-08-08 |
インサイト・コーポレイション |
Jak阻害剤を用いる化膿性汗腺炎の治療
|
|
JP7591500B2
(ja)
|
2018-08-10 |
2024-11-28 |
アクラリス セラピューティクス,インコーポレイテッド |
ピロロピリミジンitk阻害剤
|
|
GB201818750D0
(en)
*
|
2018-11-16 |
2019-01-02 |
Institute Of Cancer Res Royal Cancer Hospital |
Lox inhibitors
|
|
CN109394768B
(zh)
*
|
2018-12-10 |
2019-08-23 |
牡丹江医学院 |
一种治疗湿疹的药物及其制备方法
|
|
NL2022471B1
(en)
|
2019-01-29 |
2020-08-18 |
Vationpharma B V |
Solid state forms of oclacitinib
|
|
WO2020198583A1
(en)
|
2019-03-27 |
2020-10-01 |
Insilico Medicine Ip Limited |
Bicyclic jak inhibitors and uses thereof
|
|
AU2020265828A1
(en)
|
2019-05-02 |
2021-09-09 |
Aclaris Therapeutics, Inc. |
Substituted pyrrolopyridines as JAK inhibitors
|
|
KR102503349B1
(ko)
|
2019-05-14 |
2023-02-23 |
프로벤션 바이오, 인코포레이티드 |
제1형 당뇨병을 예방하기 위한 방법 및 조성물
|
|
CA3160312A1
(en)
|
2019-11-22 |
2021-05-27 |
Incyte Corporation |
Combination therapy comprising an alk2 inhibitor and a jak2 inhibitor
|
|
US11833155B2
(en)
|
2020-06-03 |
2023-12-05 |
Incyte Corporation |
Combination therapy for treatment of myeloproliferative neoplasms
|
|
MX2022015872A
(es)
|
2020-06-11 |
2023-05-16 |
Provention Bio Inc |
Metodos y composiciones para prevenir diabetes tipo 1.
|
|
WO2023055731A1
(en)
*
|
2021-09-28 |
2023-04-06 |
Sanford Burnham Prebys Medical Discovery Institute |
Inhibitors of serine/threonine protein kinase stk3 or stk4 and uses thereof
|