PE20000639A1 - COMPUESTOS DE PIRROLO[2,3-d]PIRIMIDINA - Google Patents
COMPUESTOS DE PIRROLO[2,3-d]PIRIMIDINAInfo
- Publication number
- PE20000639A1 PE20000639A1 PE1999000530A PE00053099A PE20000639A1 PE 20000639 A1 PE20000639 A1 PE 20000639A1 PE 1999000530 A PE1999000530 A PE 1999000530A PE 00053099 A PE00053099 A PE 00053099A PE 20000639 A1 PE20000639 A1 PE 20000639A1
- Authority
- PE
- Peru
- Prior art keywords
- cr7r8
- alkyl
- pirrolo
- group
- pyrimidine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE REFIERE A PIRROLO[2,3-d]-PIRIMIDINA DE FORMULA I DONDE R1 ES UN GRUPO IV; m, n SON 0-3; X, B, D SON O, S(O)d; d ES 0-2, NR6, CR7R8; A Y E SON CR7R8; R6 ES H, ALQUILO C1-C6, TRIFLUOROMETILO, TRIFLUOROMETIL(ALQUILO C1-C6), ENTRE OTROS; R7 Y R8 SON H, DEUTERIO, ALQUILO C1-C6, AMINO, OH, ENTRE OTROS; R1 Y R2 SON H, ALQUILO C1-C6, PIPERIDILO, ENTRE OTROS; CUANDO n ES 1; D Y E o D Y X SON CR7R8, R7 JUNTO A C FORMAN UN GRUPO V Y VI; a ES 0-2; G, J, L, M SON O, S(O)d, d ES 0-2, NR6, CR7R8; CUANDO n ES 1 D Y E SON CR7R8; m ES 1; A Y B SON CR7R8, R7 JUNTO AL C FORMA UN GRUPO XIII, r ES 0-1; c ES 0-2; R, W, Y, S SON OXIGENO, SOdNR6, CR7R8; R2 Y R3 SON H, DEUTERIO, AMINO, HALO, OH, NITRO, ENTRE OTROS; CUANDO A, B, X EN GRUPO V O VI SON NR6 O CR7R8, R2 Y R3 SON HALO; CUANDO R2 Y R3 SON H, ALQUILO C1-C6; R1 NO ES PIPERIDINILO, ENTRE OTRAS CONDICIONES. SON COMPUESTOS PREFERIDOS 5-FLUORO-4-PIPERIDIN-1-IL-7H-PIRROLO[2,3-d]PIRIMIDINA, 4-PIPERIDIN-1-IL-5-TRIFLUOROMETIL-7H-PIRROLO[2,3-d]-PIRIMIDINA, ENTRE OTROS. EL COMPUESTO I ES INHIBIDOR DE LA TIROSINQUINASA COMO LA ENZIMA JANUS QUINASA 3 POR LO QUE PUEDE SER UTIL COMO AGENTE INMUNOSUPRESOR PARA TRASPLANTES DE ORGANOS, LUPUS, ESCLEROSIS MULTIPLE, ARTRITIS REUMATOIDE, PSORIASIS, DIABETES, CANCER, ASMA, DERMATITIS, TRASTORNOS AUTOINMUNES DEL TIROIDES, COLITIS ULCEROSA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8988698P | 1998-06-19 | 1998-06-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20000639A1 true PE20000639A1 (es) | 2000-07-26 |
Family
ID=22220084
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1999000530A PE20000639A1 (es) | 1998-06-19 | 1999-06-16 | COMPUESTOS DE PIRROLO[2,3-d]PIRIMIDINA |
Country Status (47)
Families Citing this family (167)
Publication number | Priority date | Publication date | Assignee | Title |
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PA8474101A1 (es) | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
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GB0119249D0 (en) | 2001-08-07 | 2001-10-03 | Novartis Ag | Organic compounds |
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- 1999-06-14 EA EA200500614A patent/EA010377B1/ru not_active IP Right Cessation
- 1999-06-14 OA OA1200000348A patent/OA11571A/en unknown
- 1999-06-14 BR BR9912171-9A patent/BR9912171A/pt not_active Application Discontinuation
- 1999-06-16 MA MA25629A patent/MA26653A1/fr unknown
- 1999-06-16 TN TNTNSN99125A patent/TNSN99125A1/fr unknown
- 1999-06-16 EG EG72599A patent/EG23758A/xx active
- 1999-06-16 PE PE1999000530A patent/PE20000639A1/es not_active Application Discontinuation
- 1999-06-17 US US09/335,030 patent/US6635762B1/en not_active Expired - Fee Related
- 1999-06-17 AR ARP990102915A patent/AR016498A1/es active IP Right Grant
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2000
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2001
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2003
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2005
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2007
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