ES2189286T3 - Metodo de produccion de aminoalcoholes opticamente activos. - Google Patents

Metodo de produccion de aminoalcoholes opticamente activos.

Info

Publication number
ES2189286T3
ES2189286T3 ES99100704T ES99100704T ES2189286T3 ES 2189286 T3 ES2189286 T3 ES 2189286T3 ES 99100704 T ES99100704 T ES 99100704T ES 99100704 T ES99100704 T ES 99100704T ES 2189286 T3 ES2189286 T3 ES 2189286T3
Authority
ES
Spain
Prior art keywords
formula
produce
optionally replaced
procedure
optically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99100704T
Other languages
English (en)
Inventor
Takashi Inaba
Shoichi Sagawa
Hiroyuki Abe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japan Tobacco Inc
Agouron Pharmaceuticals LLC
Original Assignee
Japan Tobacco Inc
Agouron Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc, Agouron Pharmaceuticals LLC filed Critical Japan Tobacco Inc
Application granted granted Critical
Publication of ES2189286T3 publication Critical patent/ES2189286T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C07D321/02—Seven-membered rings
    • C07D321/04—Seven-membered rings not condensed with other rings
    • C07D321/06—1,3-Dioxepines; Hydrogenated 1,3-dioxepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN PROCEDIMIENTO PARA PRODUCIR UN COMPUESTO DE AMINOALCOHOL OPTICAMENTE ACTIVO REPRESENTADO POR LA FORMULA [3], UN ENANTIOMERO O UNA SAL DE DICHO COMPUESTO. DICHO PROCEDIMIENTO COMPRENDE LA REACCION DE UN COMPUESTO MESOEPOXIDO REPRESENTADO POR LA FORMULA [1] CON UN COMPUESTO REPRESENTADO POR LA FORMULA [2], EN PRESENCIA DE UN CATALIZADOR MIXTO QUE CONTIENE UN ACIDO DE LEWIS Y UN DADOR DE PROTONES: DONDE, R 1 , R 2 Y R 3 SON CADA UNO UN HI DROGENO, UN ALQUILO INFERIOR OPCIONALMENTE SUSTITUIDO, Y SIMILARES; O R 1 O R 1 O R 2 Y R 3 PUEDEN FORMAR UN CICLO OPCIONALMENTE SUSTITUIDO; R 4 Y R 5 SON CADA UNO UN HIDROGENO, UN ALQUILO INFERIOR OPCIONALMENTE SUSTITUIDO Y SIMILARES O R 4 Y R 5 PUEDEN FORMAR UN CICLO O PCIONALMENTE SUSTITUIDO JUNTO CON EL ATOMO DE NITROGENO (N) ADYACENTE O UN GRUPO IMIDA O AZIDA JUNTO CON EL ATOMO ADYACENTE N; R 6 ES UN HIDROGENO O UN GRUPO SILILO. LA PRESENTE INVENCION PERMITE LA PRODUCCION ESTEREOSELECTIVA DE UN COMPUESTO INTERMEDIO DESEADO QUE ES UN INHIBIDOR DE LA PROTEASA DE VIH, DE FORMA EXTREMADAMENTE EFICIENTE CON RESPECTO A LOS PROCEDIMIENTOS CONVENCIONALES. EL PROCEDIMIENTO DE LA PRESENTE ES MUY UTIL NO SOLO PARA PRODUCIR DICHO COMPUESTO INTERMEDIO SINO TAMBIEN PARA PRODUCIR OTROS COMPUESTOS VARIOS.
ES99100704T 1998-01-16 1999-01-15 Metodo de produccion de aminoalcoholes opticamente activos. Expired - Lifetime ES2189286T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP683698 1998-01-16

Publications (1)

Publication Number Publication Date
ES2189286T3 true ES2189286T3 (es) 2003-07-01

Family

ID=11649332

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99100704T Expired - Lifetime ES2189286T3 (es) 1998-01-16 1999-01-15 Metodo de produccion de aminoalcoholes opticamente activos.

Country Status (7)

Country Link
US (1) US6197966B1 (es)
EP (1) EP0930312B1 (es)
AT (1) ATE230406T1 (es)
AU (1) AU732148B2 (es)
DE (1) DE69904652T2 (es)
ES (1) ES2189286T3 (es)
IN (1) IN188157B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105130842B (zh) * 2015-07-31 2018-07-20 复旦大学 新型手性多齿配体、配位形成的金属有机配位聚合物催化剂及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5484926A (en) 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
DE4333686A1 (de) 1993-10-02 1995-04-06 Hoechst Ag Kinetische Racematspaltung von gesättigten Dreiring-Heterocyclen
HRP940124A2 (en) * 1994-02-21 1997-10-31 Pliva Pharm & Chem Works Novel sulfonamidodioxepanes, methods of preparation, intermediates, salts and the use thereof
WO1997011937A1 (fr) 1995-09-26 1997-04-03 Japan Tobacco Inc. Procede de production de derives amides et de leurs intermediaires
ATE416158T1 (de) * 1995-09-26 2008-12-15 Japan Tobacco Inc Verfahren zur herstellung von amidderivaten und ihren zwischenverbindungen
US5962704A (en) * 1995-09-26 1999-10-05 Japan Tobacco Inc. Production of amide derivatives and intermediate compounds therefor

Also Published As

Publication number Publication date
IN188157B (es) 2002-08-24
EP0930312A1 (en) 1999-07-21
AU1211599A (en) 1999-03-25
AU732148B2 (en) 2001-04-12
DE69904652D1 (de) 2003-02-06
DE69904652T2 (de) 2003-10-23
ATE230406T1 (de) 2003-01-15
EP0930312B1 (en) 2003-01-02
US6197966B1 (en) 2001-03-06

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