ES8705442A1 - Un procedimiento para preparar compuestos de carbapenem - Google Patents

Un procedimiento para preparar compuestos de carbapenem

Info

Publication number
ES8705442A1
ES8705442A1 ES550503A ES550503A ES8705442A1 ES 8705442 A1 ES8705442 A1 ES 8705442A1 ES 550503 A ES550503 A ES 550503A ES 550503 A ES550503 A ES 550503A ES 8705442 A1 ES8705442 A1 ES 8705442A1
Authority
ES
Spain
Prior art keywords
group
thiolcarboxyl
hydrogen atom
protected
carboxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES550503A
Other languages
English (en)
Other versions
ES550503A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharmaceuticals Co Ltd
Original Assignee
Sumitomo Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Pharmaceuticals Co Ltd filed Critical Sumitomo Pharmaceuticals Co Ltd
Publication of ES550503A0 publication Critical patent/ES550503A0/es
Publication of ES8705442A1 publication Critical patent/ES8705442A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/04—Preparation by forming the ring or condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR COMPUESTOS DE CARBAPENEM. COMPRENDE: A) HACER REACCIONAR A UN COMPUESTO DE FORMULA (II) CON (A1) EN ACETONITRILO Y BENCENO, ENTRE C75 Y 50JC, PARA PRODUCIR UN INTERMEDIO DE FORMULA (III) NO AISLADO; B) TRATAR A (III) CON (B1); Y C) HACER REACCIONAR A LA MEZCLA DE REACCION DE B) CON (C1), ENTRE C78 Y 60JC, PARA OBTENER UN COMPUESTO DE FORMULA (I). SIENDO: (A1), UNA BASE DE SALES METALICAS DE AMINAS; (B1), UN AGENTE ALQUILOIDE (YODOPRENO); (C1), AGENTE ESTERIFICANTE (ESTERES P-TOLOSULFONICO); R1, R2 Y R3, H, ALQUILO INFERIOR; R4, GRUPO PROTECTOR DE CARBOXI; XK, H; Y, S; L, UN GRUPO HIDROXI ACTIVADO; Y COZK, UN GRUPO CARBOXI PROTEGIDO. SE UTILIZAN COMO ANTIMICROBIANOS.
ES550503A 1984-12-27 1985-12-27 Un procedimiento para preparar compuestos de carbapenem Expired ES8705442A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP27945284 1984-12-27
JP14721485 1985-07-04

Publications (2)

Publication Number Publication Date
ES550503A0 ES550503A0 (es) 1987-05-01
ES8705442A1 true ES8705442A1 (es) 1987-05-01

Family

ID=26477828

Family Applications (1)

Application Number Title Priority Date Filing Date
ES550503A Expired ES8705442A1 (es) 1984-12-27 1985-12-27 Un procedimiento para preparar compuestos de carbapenem

Country Status (9)

Country Link
EP (1) EP0188816B1 (es)
JP (1) JPH0653743B2 (es)
KR (1) KR920010075B1 (es)
AU (1) AU578776B2 (es)
CA (1) CA1278295C (es)
DE (1) DE3580163D1 (es)
ES (1) ES8705442A1 (es)
IE (1) IE58810B1 (es)
NZ (1) NZ214691A (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3581481D1 (de) * 1984-10-31 1991-02-28 Sumitomo Pharma Beta-lactame und ihre herstellung.
JP2860379B2 (ja) * 1984-12-27 1999-02-24 住友製薬株式会社 β−ラクタム化合物およびその製造方法
US5310897A (en) * 1984-12-27 1994-05-10 Sumitomo Pharmaceuticals Co., Ltd. Beta-lactams and their production
ES2061439T3 (es) * 1985-12-28 1994-12-16 Sumitomo Pharma Compuesto beta-lactama y su produccion.
IE60588B1 (en) * 1986-07-30 1994-07-27 Sumitomo Pharma Carbapenem compound in crystalline form, and its production and use
WO1988001619A1 (en) * 1986-08-29 1988-03-10 Sumitomo Pharmaceuticals Company, Limited 1'-methyl-beta-lactam compounds and their production
US5312914A (en) * 1987-02-17 1994-05-17 Ciba-Geigy Corp Process for the manufacture of 4-acetoxy-3-hydroxyethyl-azetidinone
EP0279781A3 (de) * 1987-02-17 1989-07-26 Ciba-Geigy Ag Verfahren zur Herstellung von 4-Acetoxy-3-hydroxyethyl-azetidinon
JPS6425780A (en) * 1987-04-28 1989-01-27 Sankyo Co 1-methylcarbapenem derivative
EP0937725A3 (en) * 1992-04-28 2004-12-01 Tanabe Seiyaku Co., Ltd. Method for removing the protecting group for hydroxy group
JP2696807B2 (ja) * 1992-08-06 1998-01-14 田辺製薬株式会社 カルバペネム誘導体の製法
EP0684249B1 (en) * 1993-03-12 2003-02-19 Takasago International Corporation Phosphine compounds, complexes containing the phosphine compounds as ligands, and process for producing optically active aldehydes using the phosphine compounds or complexes
US5578722A (en) * 1994-03-29 1996-11-26 Sumitomo Pharmaceuticals Co., Ltd. Process for preparing carbapenem compounds
JP5079190B2 (ja) * 2001-04-27 2012-11-21 大日本住友製薬株式会社 アゼチジノン誘導体およびその製造方法
KR101059339B1 (ko) 2002-11-13 2011-08-24 가부시키가이샤 가네카 경구 투여용 카르바페넴 화합물의 제조 방법
US7538212B2 (en) 2002-11-13 2009-05-26 Kaneka Corporation Intermediate for carbapenem compound for oral administration and process for producing the same
WO2005005446A1 (ja) * 2003-07-11 2005-01-20 Nippon Soda Co., Ltd. カルバペネム中間体の製造方法
JP4463520B2 (ja) * 2003-10-02 2010-05-19 高砂香料工業株式会社 カルバペネム誘導体の製造方法
CN1960992B (zh) * 2004-06-02 2011-10-19 桑多斯股份公司 晶体形式的美罗培南中间体
WO2010087159A1 (ja) * 2009-01-28 2010-08-05 株式会社カネカ カルボキシル基と、水酸基と、カルボン酸誘導体とを同一分子内に有する有機化合物の製造方法
CN103012471A (zh) * 2012-12-17 2013-04-03 凯莱英医药集团（天津）股份有限公司 一种制备β-甲基碳青霉素烯类抗生素关键中间体的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT71553B (en) * 1979-07-23 1981-12-14 Merck & Co Inc Process for the preparation of thienamycin and intermediates
IL70782A (en) * 1983-02-02 1991-03-10 Univ Notre Dame Du Lac N-dicarboxymethyl azetidin-2-ones

Also Published As

Publication number Publication date
EP0188816B1 (en) 1990-10-17
ES550503A0 (es) 1987-05-01
KR860004893A (ko) 1986-07-14
JPH0653743B2 (ja) 1994-07-20
EP0188816A1 (en) 1986-07-30
DE3580163D1 (de) 1990-11-22
IE853323L (en) 1986-06-27
JPS62103084A (ja) 1987-05-13
CA1278295C (en) 1990-12-27
KR920010075B1 (ko) 1992-11-13
AU578776B2 (en) 1988-11-03
IE58810B1 (en) 1993-11-17
NZ214691A (en) 1988-08-30
AU5163285A (en) 1986-07-03

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Legal Events

Date Code Title Description
PC1A Transfer granted
FD1A Patent lapsed

Effective date: 20070303