CO5320601A1 - Compuestos de pirrol [2,3-d] pirimidina - Google Patents

Compuestos de pirrol [2,3-d] pirimidina

Info

Publication number
CO5320601A1
CO5320601A1 CO99038335A CO99038335A CO5320601A1 CO 5320601 A1 CO5320601 A1 CO 5320601A1 CO 99038335 A CO99038335 A CO 99038335A CO 99038335 A CO99038335 A CO 99038335A CO 5320601 A1 CO5320601 A1 CO 5320601A1
Authority
CO
Colombia
Prior art keywords
alkyl
aryl
heteroaryl
piperidyl
acyl
Prior art date
Application number
CO99038335A
Other languages
English (en)
Inventor
Todd Andrew Blumenkopf
Mark Edward Flanagan
Matthew Frank Brown
Paul Steven Chagelian
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of CO5320601A1 publication Critical patent/CO5320601A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Un compuesto de la fórmula I <EMI FILE="99038335_1" ID="1" IMF=JPEG >o sus sales farmacéuticamente aceptables, en la que R1 es un grupo de fórmula <EMI FILE="99038335_2" ID="2" IMF=JPEG >En la que la línea discontinua representa dobles enlaces opcionales; m es 0, 1, 2 ó 3n es 1, 2 ó 3X, B y O son cada uno independientemente oxígeno, S(O) siendo d 0, 1 ó 2, NR6 o CR7C8; A y E son cada uno CR7CR8; yR6 se selecciona del grupo formado por hidrógeno, alquilo C1-C6, trifluorometilo, trifluorometil(alquilo C1-C6), (alquil C1-C6) (difluorometileno), (alquil C1-C3)(difluorometilen)(alquilo C1-C3), (alcoxi C1-C6)(acilo C1-C6), (alquil C1-C6)amino(acilo C1-C6), (alquil C1-C6)2amino(acilo C1-C6), arilo C6-C10, heteroarilo C5-C9, (aril C6-C10) (alquilo C1-C6), (heteroaril C5-C9)(alquilo C1-C6), (aril C6-C10)(arilo C6-C10), (aril C6-C10)(aril C6-C10)(alquilo C1-C6), cicloalquilo C3-C6, (cicloalquil C3-C6)(alquilo C1-C6), hidroxi (alquilo C2-C6), (aciloxi C1-C6)(alquilo C2-C6), (alcoxi C1-C6)(alquilo C2-C6), piperazinil(alquilo C1-C6), (acil C1-C6)amino(alquilo C1-C6), (aril C6-C10)(alcoxi C1-C6)(alquilo C1-C6), (heteroaril C5-C9)(alcoxi C1-C6)(alquilo C1-C6), (alquil C1-C6)tio(alquilo C1-C6), (aril C6-C10)tio(alquilo C1-C6), (alquil C1-C6)sulfinil (alquilo C1-C6), (aril C6-C10)sulfinil(alquilo C1-C6), (alquil C1-C6)sulfonil(alquilo C1-C6), (aril C6-C10)sulfonil(alquilo C1-C6), aminoalquilo C1-C6, (alquil C1-C6) amino (alquilo C1-C6), (alquil C1-C6)2amino(alquilo (C1-C6), R13CO(alquilo C1-C6), donde R13 es R20O u R20R21N, seleccionándose R20 y R21 cada uno independientemente del grupo formado por hidrógeno, alquilo C1-C6, (aril C6-C10)(alquilo C1-C6) o (heteroaril C5-C9)(alquilo C1-C6); o R14(alquilo C2-C6), donde R14 es (acil C1-C6)piperazino, (aril C6-C10)piperazino, (heteroaril C5-C9)piperazino, (alquil C1-C6)piperazino, (aril C6-C10)(alquil C1-C6)piperazino, (heteroaril C5-C9)(alquil C1-C6)piperazino, morfolino, tiomorfolino, piperidino, pirrolidino, piperidilo, (alquil C1-C6)piperidilo, (aril C6-C10)piperidilo, (heteroaril C5-C9)piperidilo, (aril C6-C10)(alquil C1-C6)piperidilo, (heteroaril C5-C9) (alquil C1-C6)piperidilo, (alcoxi C1-C6)acilo, (alquil C1-C6)aminoarilo, (alquil C1-C6)2aminoacilo o (acil C1-C6)piperidilo; ...
CO99038335A 1998-06-19 1999-06-18 Compuestos de pirrol [2,3-d] pirimidina CO5320601A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8988698P 1998-06-19 1998-06-19

Publications (1)

Publication Number Publication Date
CO5320601A1 true CO5320601A1 (es) 2003-09-30

Family

ID=22220084

Family Applications (1)

Application Number Title Priority Date Filing Date
CO99038335A CO5320601A1 (es) 1998-06-19 1999-06-18 Compuestos de pirrol [2,3-d] pirimidina

Country Status (47)

Country Link
US (2) US6635762B1 (es)
EP (1) EP1087971B1 (es)
JP (1) JP3497823B2 (es)
KR (1) KR100452054B1 (es)
CN (1) CN1125070C (es)
AP (1) AP1157A (es)
AR (1) AR016498A1 (es)
AT (1) ATE270673T1 (es)
AU (1) AU758427B2 (es)
BG (1) BG65063B1 (es)
BR (1) BR9912171A (es)
CA (1) CA2335186C (es)
CO (1) CO5320601A1 (es)
CZ (1) CZ20004726A3 (es)
DE (1) DE69918552T2 (es)
DK (1) DK1087971T3 (es)
EA (2) EA010377B1 (es)
EG (1) EG23758A (es)
ES (1) ES2223172T3 (es)
GE (1) GEP20084336B (es)
GT (1) GT199900091A (es)
HK (1) HK1036800A1 (es)
HN (1) HN1999000083A (es)
HR (1) HRP20000886B1 (es)
HU (1) HUP0103472A3 (es)
ID (1) ID27595A (es)
IL (2) IL139598A0 (es)
IS (2) IS2395B (es)
MA (1) MA26653A1 (es)
MY (1) MY125802A (es)
NO (2) NO318786B1 (es)
NZ (1) NZ508034A (es)
OA (1) OA11571A (es)
PA (1) PA8474101A1 (es)
PE (1) PE20000639A1 (es)
PL (1) PL198639B1 (es)
PT (1) PT1087971E (es)
SA (1) SA99200285B1 (es)
SI (1) SI1087971T1 (es)
SK (1) SK286685B6 (es)
TN (1) TNSN99125A1 (es)
TR (1) TR200003720T2 (es)
TW (1) TW542834B (es)
UA (1) UA63013C2 (es)
WO (1) WO1999065909A1 (es)
YU (1) YU79700A (es)
ZA (1) ZA994003B (es)

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