ATE521610T1 - Spiroverbindungen und -verfahren zur modulation von chemokin-rezeptor-aktivität - Google Patents

Spiroverbindungen und -verfahren zur modulation von chemokin-rezeptor-aktivität

Info

Publication number
ATE521610T1
ATE521610T1 AT04761819T AT04761819T ATE521610T1 AT E521610 T1 ATE521610 T1 AT E521610T1 AT 04761819 T AT04761819 T AT 04761819T AT 04761819 T AT04761819 T AT 04761819T AT E521610 T1 ATE521610 T1 AT E521610T1
Authority
AT
Austria
Prior art keywords
compounds
chemokine receptor
receptor activity
spir
methods
Prior art date
Application number
AT04761819T
Other languages
English (en)
Inventor
Chun Kong Laval Chan
Ming-Qiang Zhang
Christophe Moinet
Marc Courchesne
Thumkunta Reddy
Original Assignee
Virochem Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virochem Pharma Inc filed Critical Virochem Pharma Inc
Application granted granted Critical
Publication of ATE521610T1 publication Critical patent/ATE521610T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
AT04761819T 2003-09-10 2004-09-09 Spiroverbindungen und -verfahren zur modulation von chemokin-rezeptor-aktivität ATE521610T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50140703P 2003-09-10 2003-09-10
PCT/CA2004/001656 WO2005023809A1 (en) 2003-09-10 2004-09-09 Spiro compounds and methods for the modulation of chemokine receptor activity

Publications (1)

Publication Number Publication Date
ATE521610T1 true ATE521610T1 (de) 2011-09-15

Family

ID=34273044

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04761819T ATE521610T1 (de) 2003-09-10 2004-09-09 Spiroverbindungen und -verfahren zur modulation von chemokin-rezeptor-aktivität

Country Status (5)

Country Link
US (1) US7288548B2 (de)
EP (1) EP1786815B1 (de)
AT (1) ATE521610T1 (de)
CA (1) CA2579608A1 (de)
WO (1) WO2005023809A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2676B1 (en) * 2004-04-06 2012-06-17 جانسين فارماسوتيكا ان. في Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines
WO2006000096A1 (en) * 2004-06-25 2006-01-05 Virochem Pharma Inc. Spirohydantoin compounds and methods for the modulation of chemokine receptor activity
WO2006060918A1 (en) * 2004-12-09 2006-06-15 Virochem Pharma Inc. Novel spirotropane compounds and methods for the modulation of chemokine receptor activity
EP1831222A4 (de) 2004-12-09 2009-10-21 Virochem Pharma Inc Neue spirotropanverbindungen und verfahren zur modulierung der aktivität des chemokinrezeptors
ES2350647T3 (es) * 2005-03-08 2011-01-25 Janssen Pharmaceutica Nv Derivados de diaza-espiro-[4.4]-nonano como antagonistas de neuroquininas (nk1).
CA2759651A1 (en) * 2009-05-07 2010-11-11 Merck Sharp & Dohme Corp. Substituted spirocyclic amines useful as antidiabetic compounds
TW201444798A (zh) 2013-02-28 2014-12-01 必治妥美雅史谷比公司 作爲強效ｒｏｃｋ１及ｒｏｃｋ２抑制劑之苯基吡唑衍生物
EP2961746B1 (de) 2013-02-28 2018-01-03 Bristol-Myers Squibb Company Phenylpyrazolderivate als potente rock1- und rock2-inhibitoren
CN108982465B (zh) * 2018-06-06 2020-10-02 上海应用技术大学 酒中二氧化硫高通量sers在线检测方法
WO2020113094A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
CA3163243A1 (en) * 2019-12-03 2021-06-10 Kallyope, Inc. Sstr5 antagonists

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8401907A (nl) * 1983-06-27 1985-01-16 Sandoz Ag Spirosuccinimiden en werkwijzen voor het bereiden en toepassen van deze spirosuccinimiden.
JP2001526178A (ja) 1997-08-28 2001-12-18 メルク エンド カムパニー インコーポレーテッド ピロリジン系およびピペリジン系ケモカイン受容体活性調節剤
AU3389300A (en) 1999-03-02 2000-09-21 Merck & Co., Inc. Pyrrolidine modulators of chemokine receptor activity
US6362201B1 (en) 1999-03-02 2002-03-26 Merck & Co., Inc. 3-cyclopropyl and 3-cyclobutyl pyrrolidine modulators of chemokine receptor activity
AU3386700A (en) 1999-03-02 2000-09-21 Merck & Co., Inc. 3-thienyl and 3-furanyl pyrrolidine modulators of chemokine receptor activity
AU3386400A (en) 1999-03-02 2000-09-21 Merck & Co., Inc. 3-alkyl substituted pyrrolidine modulators of chemokine receptor activity
US6248755B1 (en) 1999-04-06 2001-06-19 Merck & Co., Inc. Pyrrolidine modulators of chemokine receptor activity
AU1244001A (en) 1999-10-27 2001-05-08 Cor Therapeutics, Inc. Pyridyl-containing spirocyclic compounds as inhibitors of fibrinogen-dependent platelet aggregation
JP2002095730A (ja) 2000-07-21 2002-04-02 Midori Anzen Co Ltd 脱臭材及びその製造方法
EP1326619A2 (de) 2000-10-11 2003-07-16 Merck & Co., Inc. Pyrrolidin-modulatoren der ccr5-chemokin-rezeptor-aktivität
EP1461339B1 (de) * 2001-12-28 2010-04-28 Acadia Pharmaceuticals Inc. Spiroazacyclische verbindungen als monoaminrezeptormodulatoren
WO2004058702A2 (en) 2002-12-23 2004-07-15 Merck & Co., Inc. 4-[(4-(carboxyethyl) piperidinyl) methyl] pyrrolidines as modulators of chemokine receptor activity
WO2004058763A1 (en) 2002-12-23 2004-07-15 Merck & Co., Inc. 4(spiropiperidinyl)methyl substituted pyrrolidines as modulators of chemokine receptor activity

Also Published As

Publication number Publication date
US7288548B2 (en) 2007-10-30
EP1786815A1 (de) 2007-05-23
EP1786815B1 (de) 2011-08-24
EP1786815A4 (de) 2009-03-18
US20050070563A1 (en) 2005-03-31
WO2005023809A1 (en) 2005-03-17
CA2579608A1 (en) 2005-03-17

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