CO5200757A1 - Derivados de 4-indol benzamidas con actividad contra la osteoporosis, sus sales farmaceuticamente aceptables y composiciones farmaceuticas que los contienen - Google Patents
Derivados de 4-indol benzamidas con actividad contra la osteoporosis, sus sales farmaceuticamente aceptables y composiciones farmaceuticas que los contienenInfo
- Publication number
- CO5200757A1 CO5200757A1 CO00045017A CO00045017A CO5200757A1 CO 5200757 A1 CO5200757 A1 CO 5200757A1 CO 00045017 A CO00045017 A CO 00045017A CO 00045017 A CO00045017 A CO 00045017A CO 5200757 A1 CO5200757 A1 CO 5200757A1
- Authority
- CO
- Colombia
- Prior art keywords
- dichloro
- indole
- alkoxy
- indol
- tetramethylpiperidin
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Virology (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Communicable Diseases (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Tropical Medicine & Parasitology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Transplantation (AREA)
- Obesity (AREA)
- Cardiology (AREA)
Abstract
Un compuesto de fórmula (I)<EMI FILE="00045017_1" ID="1" IMF=JPEG >o una de sus sales, o uno de sus solvatos,en la que:R1 y R2, cada uno independientemente, representan alcoxi C1-6 o halo;R3 y R4, cada uno independientemente, representan hidrógeno, alcoxi C1-6, aril-alcoxi C1-6, hidroxi, carboxi-alcoxi C1-6, hidroxi-alcoxi C1-6, dihidroxi-alcoxi C1-6, mono- y di-alquil C1-6-amino-alcoxi C1-6 o amino-alcoxi C1-6, yR5 representa -NRsRt, donde Rs y Rt, cada uno independientemente, representan hidrógeno, alquilo C1-6 sustituido o no sustituido, o heterociclilo sustituido o no sustituido.1Un compuesto de fórmula (IA)<EMI FILE="00045017_2" ID="2" IMF=JPEG >en la que:R1, R2, R3, R4 y R5 son como se han definido en la fórmula (I) de la reivindicación 1, Rs es 3-[4-(3-metoxifenil)piperazin-1-il]propilo o 3-[4-(2-pirimidinil)piperazin-1-il]propilo, y Rt es hidrógeno o una de sus sales o uno de sus solvatos.1Un compuesto seleccionado de la lista constituida por:4-(5,6-dicloro-1H-indol-2-il)-3-etoxi-N-(2,2,6,6-tetrametilpiperidin-4-il)-benzamida;4-(5,6-dicloro-1H-indol-2-il)-3-benciloxi-N-(2,2,6,6-tetrametilpiperidin-4-il)-benzamida;4-(5,6-dicloro-1H-indol-2-il)-3-hidroxi-N-(2,2,6,6-tetrametilpiperidin-4-iI)-benzamida;4-(5,6-dicloro-1H-indol-2-il)-3-propoxi-N-(2,2,6,6-tetrametilpiperidin-4-il)-benzamida;4-(5,6-dicloro-1H-indol-2-il)-N-[3-[4-(3-metoxifenil)piperazin-1-il]propil]-3-metoxibenzamida;4-(5,6-dicloro-1H-indoI-2-il)-N-[3-[4-(2-pirimidil)piperazin-1- il]propil]-3-metoxibenzamida;4-(5,6-dicloro-1H-indol-2-il)-N-(2,2,6,6-tetrametilpiperidin-4-il)-3-metoxibenzamida;4-(5,6-dicloro-1H-indol-2-il)-N-(1,2,2,6,6-pentametilpiperidin-4-il)-3-etoxibenzamida;4-(5,6-dicloro-1H-indol-2-il)-N-(3-piridil)-3-etoxibenzamida;4-(5,6-dicloro-1H-indol-2-il)-N-(3-(6-metoxipiridil)-3-etoxibenzamida; 4-(5,6-dicloro-1H-indol-2-iI)-N-(1-bencilpiperidin-4-il)-3-etoxibenzamida; ...
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9914371.1A GB9914371D0 (en) | 1999-06-18 | 1999-06-18 | Novel compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5200757A1 true CO5200757A1 (es) | 2002-09-27 |
Family
ID=10855696
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO00045017A CO5200757A1 (es) | 1999-06-18 | 2000-06-16 | Derivados de 4-indol benzamidas con actividad contra la osteoporosis, sus sales farmaceuticamente aceptables y composiciones farmaceuticas que los contienen |
Country Status (30)
Country | Link |
---|---|
US (2) | US6787550B1 (es) |
EP (1) | EP1212317B1 (es) |
JP (1) | JP2003503490A (es) |
KR (1) | KR100701109B1 (es) |
CN (1) | CN1179960C (es) |
AR (1) | AR024390A1 (es) |
AT (1) | ATE276245T1 (es) |
AU (1) | AU768726B2 (es) |
BR (1) | BR0011708A (es) |
CA (1) | CA2376657A1 (es) |
CO (1) | CO5200757A1 (es) |
CZ (1) | CZ301697B6 (es) |
DE (1) | DE60013859T2 (es) |
DK (1) | DK1212317T3 (es) |
ES (1) | ES2226870T3 (es) |
GB (1) | GB9914371D0 (es) |
GC (1) | GC0000341A (es) |
HK (2) | HK1048468B (es) |
HU (1) | HUP0202049A3 (es) |
IL (2) | IL147012A0 (es) |
MX (1) | MXPA01013277A (es) |
MY (1) | MY129425A (es) |
NO (1) | NO322313B1 (es) |
NZ (1) | NZ516131A (es) |
PL (1) | PL352964A1 (es) |
PT (1) | PT1212317E (es) |
TR (1) | TR200103683T2 (es) |
TW (1) | TWI248440B (es) |
WO (1) | WO2001002388A1 (es) |
ZA (1) | ZA200200177B (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101106631B1 (ko) | 2003-02-13 | 2012-01-20 | 웰스태트 테러퓨틱스 코포레이션 | 대사 질환의 치료용 화합물 |
AU2004259703A1 (en) * | 2003-07-15 | 2005-02-03 | Smithkline Beecham Corporation | Novel compounds |
ITMI20040875A1 (it) * | 2004-04-30 | 2004-07-30 | Ist Naz Stud Cura Dei Tumori | Derivati indolici utili per il trattamento della resistenza agli agenti antitumorali |
AU2005305609B2 (en) | 2004-09-17 | 2011-10-06 | Idenix Pharmaceuticals, Inc. | Phosphoindoles as HIV inhibitors |
CA2582674A1 (en) * | 2004-10-04 | 2006-04-20 | Myriad Genetics, Inc. | Compounds for alzheimer's disease |
US7833805B2 (en) * | 2004-10-21 | 2010-11-16 | University Of Cincinnati | Selectively permeable membranes on porous substrates |
EP1911744B1 (en) | 2005-07-20 | 2013-09-04 | Masanori Somei | Tryptophan derivative and use thereof |
ITRM20050389A1 (it) | 2005-07-22 | 2007-01-23 | Giuliani Spa | Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico. |
ITRM20050390A1 (it) * | 2005-07-22 | 2007-01-23 | Giuliani Spa | Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico. |
CA2618634A1 (en) | 2005-08-15 | 2007-02-22 | Irm Llc | Compounds and compositions as tpo mimetics |
EP1779849A1 (en) * | 2005-10-28 | 2007-05-02 | Nikem Research S.R.L. | V-ATPase inhibitors for the treatment of septic shock |
EP1779848A1 (en) | 2005-10-28 | 2007-05-02 | Nikem Research S.R.L. | V-ATPase inhibitors for the treatment of inflammatory and autoimmune diseases |
US7820721B2 (en) | 2006-01-25 | 2010-10-26 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
KR20080089453A (ko) | 2006-01-25 | 2008-10-06 | 웰스태트 테러퓨틱스 코포레이션 | 물질대사 장애의 치료용 화합물 |
EP1978948A4 (en) | 2006-02-02 | 2010-06-16 | Wellstat Therapeutics Corp | COMPOUNDS FOR THE TREATMENT OF METABOLISM DISORDER |
JP2009543805A (ja) * | 2006-07-13 | 2009-12-10 | スミスクライン ビーチャム コーポレーション | インドリン誘導体及びgpr119作動物質 |
NZ575831A (en) | 2006-09-29 | 2011-12-22 | Idenix Pharmaceuticals Inc | Enantiomerically pure phosphoindoles as hiv inhibitors |
UA107562C2 (uk) | 2008-12-05 | 2015-01-26 | Спосіб лікування псоріазу | |
BRPI1008752B1 (pt) | 2009-02-16 | 2020-02-11 | Nogra Pharma Limited | Compostos alquilamido, composições farmacêuticas e usos dos mesmos |
WO2010144611A2 (en) * | 2009-06-10 | 2010-12-16 | 3-V Biosciences, Inc. | Antivirals that target transporters, carriers, and ion channels |
SI2614052T1 (sl) * | 2010-09-08 | 2015-04-30 | Bristol-Myers Squibb Company | Novi analogi piperazina kot širokospektralna protivirusna sredstva proti gripi |
WO2012045451A1 (en) | 2010-10-05 | 2012-04-12 | Ludwig-Maximilians-Universitaet Muenchen | Novel therapeutic treatment of progranulin-dependent diseases |
US20120142627A1 (en) * | 2010-12-06 | 2012-06-07 | Emory University | Monophosphate prodrugs of dapd and analogs thereof |
JP6301844B2 (ja) | 2012-02-09 | 2018-03-28 | ノグラ ファーマ リミテッド | 線維症の処置方法 |
KR20150002819A (ko) | 2012-04-18 | 2015-01-07 | 노그라 파마 리미티드 | 락토스 불내증의 치료 방법 |
CN113825739A (zh) | 2019-02-08 | 2021-12-21 | 诺格拉制药有限公司 | 制备3-(4’-氨基苯基)-2-甲氧基丙酸及其类似物和中间体的方法 |
CN113024432A (zh) * | 2019-12-24 | 2021-06-25 | 上海科胜药物研发有限公司 | 一种氨磺必利药典杂质的制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2124511C1 (ru) * | 1993-05-14 | 1999-01-10 | Фармасьютикал Ко., Лтд | Производные пиперазина |
JPH10512251A (ja) | 1995-01-10 | 1998-11-24 | スミスクライン・ビーチャム・ソシエタ・ペル・アチオニ | 骨粗鬆症の治療に有用なインドール誘導体 |
ATE277037T1 (de) * | 1996-07-09 | 2004-10-15 | Nikem Research Srl | Indolderivate zur behandlung von osteoporose |
KR20010033528A (ko) | 1997-12-24 | 2001-04-25 | 헨리 필리 파르, 올리비에 보우언 | 골다공증의 치료를 위한 a.o.에 유용한 인돌 유도체 |
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1999
- 1999-06-18 GB GBGB9914371.1A patent/GB9914371D0/en not_active Ceased
-
2000
- 2000-06-16 CN CNB008115974A patent/CN1179960C/zh not_active Expired - Fee Related
- 2000-06-16 CO CO00045017A patent/CO5200757A1/es not_active Application Discontinuation
- 2000-06-16 HU HU0202049A patent/HUP0202049A3/hu unknown
- 2000-06-16 AT AT00943839T patent/ATE276245T1/de not_active IP Right Cessation
- 2000-06-16 NZ NZ516131A patent/NZ516131A/en unknown
- 2000-06-16 ES ES00943839T patent/ES2226870T3/es not_active Expired - Lifetime
- 2000-06-16 MY MYPI20002728A patent/MY129425A/en unknown
- 2000-06-16 DE DE60013859T patent/DE60013859T2/de not_active Expired - Lifetime
- 2000-06-16 IL IL14701200A patent/IL147012A0/xx active IP Right Grant
- 2000-06-16 US US10/018,443 patent/US6787550B1/en not_active Expired - Fee Related
- 2000-06-16 TR TR2001/03683T patent/TR200103683T2/xx unknown
- 2000-06-16 WO PCT/EP2000/005672 patent/WO2001002388A1/en active IP Right Grant
- 2000-06-16 AU AU58165/00A patent/AU768726B2/en not_active Ceased
- 2000-06-16 KR KR1020017016180A patent/KR100701109B1/ko not_active IP Right Cessation
- 2000-06-16 CZ CZ20014496A patent/CZ301697B6/cs not_active IP Right Cessation
- 2000-06-16 PL PL00352964A patent/PL352964A1/xx not_active IP Right Cessation
- 2000-06-16 BR BR0011708-0A patent/BR0011708A/pt not_active IP Right Cessation
- 2000-06-16 AR ARP000103010A patent/AR024390A1/es not_active Application Discontinuation
- 2000-06-16 DK DK00943839T patent/DK1212317T3/da active
- 2000-06-16 CA CA002376657A patent/CA2376657A1/en not_active Abandoned
- 2000-06-16 PT PT00943839T patent/PT1212317E/pt unknown
- 2000-06-16 MX MXPA01013277A patent/MXPA01013277A/es active IP Right Grant
- 2000-06-16 JP JP2001507825A patent/JP2003503490A/ja active Pending
- 2000-06-16 EP EP00943839A patent/EP1212317B1/en not_active Expired - Lifetime
- 2000-06-18 GC GCP2000726 patent/GC0000341A/en active
- 2000-07-06 TW TW089113348A patent/TWI248440B/zh not_active IP Right Cessation
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2001
- 2001-12-10 IL IL147012A patent/IL147012A/en not_active IP Right Cessation
- 2001-12-17 NO NO20016149A patent/NO322313B1/no not_active IP Right Cessation
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2002
- 2002-01-09 ZA ZA200200177A patent/ZA200200177B/en unknown
- 2002-11-19 HK HK02108380.9A patent/HK1048468B/zh not_active IP Right Cessation
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2003
- 2003-02-20 HK HK03101303.7A patent/HK1049164A1/zh unknown
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2004
- 2004-06-24 US US10/875,356 patent/US20040235930A1/en not_active Abandoned
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