BR0011708A - Derivados de indol e seu uso para o tratamento de osteoporose dentre outras aplicações - Google Patents
Derivados de indol e seu uso para o tratamento de osteoporose dentre outras aplicaçõesInfo
- Publication number
- BR0011708A BR0011708A BR0011708-0A BR0011708A BR0011708A BR 0011708 A BR0011708 A BR 0011708A BR 0011708 A BR0011708 A BR 0011708A BR 0011708 A BR0011708 A BR 0011708A
- Authority
- BR
- Brazil
- Prior art keywords
- alkoxy
- activity
- compounds
- treatment
- compound
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Virology (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
Abstract
"DERIVADOS DE INDOL E SEU USO PARA O TRATAMENTO DE OSTEOPOROSE DENTRE OUTRAS APLICAçõES". Composto de fórmula ( I ), ou seu sal ou solvato, em que: R~ 1~ e R~ 2~ representarem cada um independentemente alcóxi C~ 1-6~ ou halo; R~ 3~ e R~ 4~ representarem cada um independentemente hidrogênio, alcóxi C~ 1-6~, aril alcóxi C~ 1-6~, hidróxi, carbóxi alcóxi C~ 1-6~, hidróxi alcóxi C~ 1-6~, diidróxi alcóxi C~ 1-6~, mono- e di(alquil C~ 1-6~) amino alcóxi C~ 1-6~, ou amino alcóxi C~ 1-6~, e R~ 5~ representar -NR~ s~R~ t~, em que R~ s~ e R~ t~ representam cada um independentemente hidrogênio, alquila C~ 1-6~ não substituída ou substituída, ou heterociclila não substituída ou substituída, processo para a preparação desse composto, composição farmacêutica contendo esse composto e o uso do composto ou composição em medicina. Compostos de indol particulares são seletivos para osteoclastos de mamíferos, agindo na inibição seletiva de sua atividade de reabsorção óssea. Esses compostos são, portanto, considerados particularmente úteis para o tratamento e/ou profilaxia de doenças associadas à perda de massa óssea, como osteoporose e doenças osteopênicas relacionadas, doença de Paget, hiperparatireoidismo e doenças relacionadas. Também se considera que esses compostos possuam atividade antitumoral, atividade antiviral ( por exemplo, contra os vírus Semliki Forest, da Estomatite Vesicular, da Doença de Newcastle, da Influenza A e B, HIV ), atividade antiúlcera ( por exemplo, os compostos podem ser úteis para o tratamento de gastrite crónica e úlcera péptica induzida por Helicobacter pylori ), atividade imunossupressora, atividade antilipidêmica, atividade antiaterosclerótica e úteis para o tratamento de AIDS e doença de Alzheimer. Além disso, esses compostos também são considerados úteis na inibição da angiogênese, isto é, a formação de novos vasos sang³íneos que é observada em vários tipos de estados patológicos ( doenças angiogênicas ), como artrite reumatóide, retinopatia diabética, psoríase e tumores sólidos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9914371.1A GB9914371D0 (en) | 1999-06-18 | 1999-06-18 | Novel compounds |
PCT/EP2000/005672 WO2001002388A1 (en) | 1999-06-18 | 2000-06-16 | Indole derivatives and their use for the treatment of osteoporosis amongst other applications |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0011708A true BR0011708A (pt) | 2002-05-21 |
Family
ID=10855696
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0011708-0A BR0011708A (pt) | 1999-06-18 | 2000-06-16 | Derivados de indol e seu uso para o tratamento de osteoporose dentre outras aplicações |
Country Status (30)
Country | Link |
---|---|
US (2) | US6787550B1 (pt) |
EP (1) | EP1212317B1 (pt) |
JP (1) | JP2003503490A (pt) |
KR (1) | KR100701109B1 (pt) |
CN (1) | CN1179960C (pt) |
AR (1) | AR024390A1 (pt) |
AT (1) | ATE276245T1 (pt) |
AU (1) | AU768726B2 (pt) |
BR (1) | BR0011708A (pt) |
CA (1) | CA2376657A1 (pt) |
CO (1) | CO5200757A1 (pt) |
CZ (1) | CZ301697B6 (pt) |
DE (1) | DE60013859T2 (pt) |
DK (1) | DK1212317T3 (pt) |
ES (1) | ES2226870T3 (pt) |
GB (1) | GB9914371D0 (pt) |
GC (1) | GC0000341A (pt) |
HK (2) | HK1048468B (pt) |
HU (1) | HUP0202049A3 (pt) |
IL (2) | IL147012A0 (pt) |
MX (1) | MXPA01013277A (pt) |
MY (1) | MY129425A (pt) |
NO (1) | NO322313B1 (pt) |
NZ (1) | NZ516131A (pt) |
PL (1) | PL352964A1 (pt) |
PT (1) | PT1212317E (pt) |
TR (1) | TR200103683T2 (pt) |
TW (1) | TWI248440B (pt) |
WO (1) | WO2001002388A1 (pt) |
ZA (1) | ZA200200177B (pt) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7615575B2 (en) | 2003-02-13 | 2009-11-10 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
WO2005009993A1 (en) * | 2003-07-15 | 2005-02-03 | Smithkline Beecham Corporation | Novel compounds |
ITMI20040875A1 (it) * | 2004-04-30 | 2004-07-30 | Ist Naz Stud Cura Dei Tumori | Derivati indolici utili per il trattamento della resistenza agli agenti antitumorali |
KR101242962B1 (ko) | 2004-09-17 | 2013-03-13 | 아이데닉스 파마슈티칼스, 인코포레이티드 | Hiv 억제제로서의 포스포인돌 |
EP2813498B1 (en) * | 2004-10-04 | 2016-04-20 | Manfredi, John | Compounds for Alzheimer's disease |
US7833805B2 (en) * | 2004-10-21 | 2010-11-16 | University Of Cincinnati | Selectively permeable membranes on porous substrates |
WO2007010723A1 (ja) * | 2005-07-20 | 2007-01-25 | National University Corporation Kanazawa University | トリプトファン誘導体及びその用途 |
ITRM20050390A1 (it) | 2005-07-22 | 2007-01-23 | Giuliani Spa | Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico. |
ITRM20050389A1 (it) | 2005-07-22 | 2007-01-23 | Giuliani Spa | Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico. |
RU2385865C2 (ru) * | 2005-08-15 | 2010-04-10 | Айрм Ллк | Соединения и композиции в качестве миметиков тро |
EP1779848A1 (en) * | 2005-10-28 | 2007-05-02 | Nikem Research S.R.L. | V-ATPase inhibitors for the treatment of inflammatory and autoimmune diseases |
EP1779849A1 (en) * | 2005-10-28 | 2007-05-02 | Nikem Research S.R.L. | V-ATPase inhibitors for the treatment of septic shock |
CA2637373A1 (en) | 2006-01-25 | 2007-08-02 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
US7820721B2 (en) | 2006-01-25 | 2010-10-26 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
AU2007212104A1 (en) | 2006-02-02 | 2007-08-16 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
JP2009543805A (ja) * | 2006-07-13 | 2009-12-10 | スミスクライン ビーチャム コーポレーション | インドリン誘導体及びgpr119作動物質 |
WO2008042240A2 (en) | 2006-09-29 | 2008-04-10 | Idenix Pharmaceuticals, Inc. | Enantiomerically pure phosphoindoles as hiv inhibitors |
UA107562C2 (uk) | 2008-12-05 | 2015-01-26 | Спосіб лікування псоріазу | |
MX2011008601A (es) | 2009-02-16 | 2011-09-09 | Giuliani Int Ltd | Compuestos de alquilamido y usos de los mismos. |
US20110038852A1 (en) * | 2009-06-10 | 2011-02-17 | 3-V Biosciences, Inc. | Antivirals that target transporters, carriers, and ion channels |
RS53844B1 (en) * | 2010-09-08 | 2015-08-31 | Bristol-Myers Squibb Company | NEW PIPERAZINE ANALYSIS AS A WIDER ANTI-VIRUS MEDICINE AGAINST VIRUS INFLUENCE |
WO2012045451A1 (en) | 2010-10-05 | 2012-04-12 | Ludwig-Maximilians-Universitaet Muenchen | Novel therapeutic treatment of progranulin-dependent diseases |
US20120142627A1 (en) * | 2010-12-06 | 2012-06-07 | Emory University | Monophosphate prodrugs of dapd and analogs thereof |
CN104254327A (zh) | 2012-02-09 | 2014-12-31 | 诺格拉制药有限公司 | 治疗纤维化的方法 |
IN2014DN08157A (pt) | 2012-04-18 | 2015-05-01 | Nogra Pharma Ltd | |
KR20210125047A (ko) | 2019-02-08 | 2021-10-15 | 노그라 파마 리미티드 | 3-(4'-아미노페닐)-2-메톡시프로피온산, 및 그의 유사체 및 중간체의 제조 방법 |
CN113024432A (zh) * | 2019-12-24 | 2021-06-25 | 上海科胜药物研发有限公司 | 一种氨磺必利药典杂质的制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2124511C1 (ru) * | 1993-05-14 | 1999-01-10 | Фармасьютикал Ко., Лтд | Производные пиперазина |
BR9606743A (pt) * | 1995-01-10 | 1997-12-30 | Smithkline Beecham Spa | Derivados indol úteis no tratamento de osteoporose |
ES2229375T3 (es) * | 1996-07-09 | 2005-04-16 | Nikem Research S.R.L. | Derivados del indol para el tratamiento de la osteoporosis. |
ATE288909T1 (de) * | 1997-12-24 | 2005-02-15 | Nikem Research Srl | Indolderivate verwendbar zur behandlung von u.a. osteoporosis |
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1999
- 1999-06-18 GB GBGB9914371.1A patent/GB9914371D0/en not_active Ceased
-
2000
- 2000-06-16 BR BR0011708-0A patent/BR0011708A/pt not_active IP Right Cessation
- 2000-06-16 CA CA002376657A patent/CA2376657A1/en not_active Abandoned
- 2000-06-16 ES ES00943839T patent/ES2226870T3/es not_active Expired - Lifetime
- 2000-06-16 MY MYPI20002728A patent/MY129425A/en unknown
- 2000-06-16 DE DE60013859T patent/DE60013859T2/de not_active Expired - Lifetime
- 2000-06-16 WO PCT/EP2000/005672 patent/WO2001002388A1/en active IP Right Grant
- 2000-06-16 AR ARP000103010A patent/AR024390A1/es not_active Application Discontinuation
- 2000-06-16 PT PT00943839T patent/PT1212317E/pt unknown
- 2000-06-16 TR TR2001/03683T patent/TR200103683T2/xx unknown
- 2000-06-16 AU AU58165/00A patent/AU768726B2/en not_active Ceased
- 2000-06-16 IL IL14701200A patent/IL147012A0/xx active IP Right Grant
- 2000-06-16 HU HU0202049A patent/HUP0202049A3/hu unknown
- 2000-06-16 KR KR1020017016180A patent/KR100701109B1/ko not_active IP Right Cessation
- 2000-06-16 DK DK00943839T patent/DK1212317T3/da active
- 2000-06-16 JP JP2001507825A patent/JP2003503490A/ja active Pending
- 2000-06-16 AT AT00943839T patent/ATE276245T1/de not_active IP Right Cessation
- 2000-06-16 US US10/018,443 patent/US6787550B1/en not_active Expired - Fee Related
- 2000-06-16 EP EP00943839A patent/EP1212317B1/en not_active Expired - Lifetime
- 2000-06-16 NZ NZ516131A patent/NZ516131A/en unknown
- 2000-06-16 CZ CZ20014496A patent/CZ301697B6/cs not_active IP Right Cessation
- 2000-06-16 PL PL00352964A patent/PL352964A1/xx not_active IP Right Cessation
- 2000-06-16 MX MXPA01013277A patent/MXPA01013277A/es active IP Right Grant
- 2000-06-16 CO CO00045017A patent/CO5200757A1/es not_active Application Discontinuation
- 2000-06-16 CN CNB008115974A patent/CN1179960C/zh not_active Expired - Fee Related
- 2000-06-18 GC GCP2000726 patent/GC0000341A/en active
- 2000-07-06 TW TW089113348A patent/TWI248440B/zh not_active IP Right Cessation
-
2001
- 2001-12-10 IL IL147012A patent/IL147012A/en not_active IP Right Cessation
- 2001-12-17 NO NO20016149A patent/NO322313B1/no not_active IP Right Cessation
-
2002
- 2002-01-09 ZA ZA200200177A patent/ZA200200177B/en unknown
- 2002-11-19 HK HK02108380.9A patent/HK1048468B/zh not_active IP Right Cessation
-
2003
- 2003-02-20 HK HK03101303.7A patent/HK1049164A1/zh unknown
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2004
- 2004-06-24 US US10/875,356 patent/US20040235930A1/en not_active Abandoned
Also Published As
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