BR9914453A - Cristal de tetrafosfato de diuridina ou seu sal, método de sua preparação e método de produção do mencionado composto - Google Patents
Cristal de tetrafosfato de diuridina ou seu sal, método de sua preparação e método de produção do mencionado compostoInfo
- Publication number
- BR9914453A BR9914453A BR9914453-0A BR9914453A BR9914453A BR 9914453 A BR9914453 A BR 9914453A BR 9914453 A BR9914453 A BR 9914453A BR 9914453 A BR9914453 A BR 9914453A
- Authority
- BR
- Brazil
- Prior art keywords
- ump
- salts
- preparation
- salt
- ppi
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 6
- 150000003839 salts Chemical class 0.000 title abstract 6
- 239000013078 crystal Substances 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title abstract 4
- 238000002360 preparation method Methods 0.000 title abstract 3
- VBGNEGYAPSWNQQ-VWDXAFRGSA-N 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione [hydroxy(phosphonooxy)phosphoryl] phosphono hydrogen phosphate Chemical compound OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O.OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O.OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(O)=O VBGNEGYAPSWNQQ-VWDXAFRGSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 abstract 2
- 150000001447 alkali salts Chemical class 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 239000002994 raw material Substances 0.000 abstract 2
- SBVYRQFJZOKNGO-XVFCMESISA-N [[(2r,3s,4r,5r)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [hydroxy(phosphonooxy)phosphoryl] hydrogen phosphate Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1N1C(=O)NC(=O)C=C1 SBVYRQFJZOKNGO-XVFCMESISA-N 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000002131 composite material Substances 0.000 abstract 1
- ASMQGLCHMVWBQR-UHFFFAOYSA-M diphenyl phosphate Chemical compound C=1C=CC=CC=1OP(=O)([O-])OC1=CC=CC=C1 ASMQGLCHMVWBQR-UHFFFAOYSA-M 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 abstract 1
- 229940045145 uridine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Patente de Invenção <B>"CRISTAL DE TETRAFOSFATO DE DIURIDINA OU SEU SAL, MéTODO DE SUA PREPARAçãO E MéTODO DE PRODUçãO DO MENCIONADO COMPOSTO"<D>, caracterizado pelo fato de que, a presente invenção proporciona cristais de 5' -tetrafosfato de P^ 1^, P^ 4^-di (uridina) ou um de seus sais; um processo de produção dos cristais; e um processo de produção de 5' -tetrafosfato de P^ 1^, P^ 4^-di (uridina) (U~ 2~P~ 4~) ou um de seus sais a partir de UMP, que serve de matéria-prima, e através da utilização de DPC e PPi, com o processo compreendendo pelo menos uma das etapas de tratamento a seguir: (a) adição de UMP e fosfato de difenila (UMP-DPP) em porções divididas durante uma etapa de reação de UMP-DPP com um sal álcali orgânico de PPi; (b) condução da reação de UMP-DPP com um sal álcali orgânico de PPi na presença de uma base; e (c) tratamento adicional do U~ 2~P~ 4~ sintetizado com um álcali. Os cristais de U~ 2~P~ 4~ ou um de seus sais obtidos através do processo de acordo com a presente invenção possuem alta pureza e estabilidade e menor higroscopicidade em comparação com um produto liofilizado, de forma a servir de matéria-prima útil para a preparação de um produto farmacêutico. O processo de produção de U~ 2~P~ 4~ ou um de seus sais de acordo com a presente invenção atinge alto rendimento e permite a síntese em larga escala.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BRPI9917911A BRPI9917911B1 (pt) | 1998-10-02 | 1999-10-01 | processo de produção de 5'-tetrafosfato de p1,p4 - di(uridina) ou um de seus sais |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP28166398 | 1998-10-02 | ||
| JP17068199 | 1999-06-17 | ||
| PCT/JP1999/005415 WO2000020430A1 (fr) | 1998-10-02 | 1999-10-01 | Cristal de diuridine tetraphosphate ou sel correspondant et procede de fabrication |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9914453A true BR9914453A (pt) | 2001-05-22 |
Family
ID=26493605
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9914453-0A BR9914453A (pt) | 1998-10-02 | 1999-10-01 | Cristal de tetrafosfato de diuridina ou seu sal, método de sua preparação e método de produção do mencionado composto |
| BRPI9917911A BRPI9917911B1 (pt) | 1998-10-02 | 1999-10-01 | processo de produção de 5'-tetrafosfato de p1,p4 - di(uridina) ou um de seus sais |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9917911A BRPI9917911B1 (pt) | 1998-10-02 | 1999-10-01 | processo de produção de 5'-tetrafosfato de p1,p4 - di(uridina) ou um de seus sais |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US6458946B1 (pt) |
| EP (1) | EP1043329B1 (pt) |
| JP (2) | JP3247685B2 (pt) |
| KR (1) | KR100475008B1 (pt) |
| CN (2) | CN100396692C (pt) |
| AT (1) | ATE222920T1 (pt) |
| AU (1) | AU747096C (pt) |
| BR (2) | BR9914453A (pt) |
| CA (1) | CA2345624C (pt) |
| CZ (1) | CZ300402B6 (pt) |
| DE (1) | DE69902624T2 (pt) |
| EA (2) | EA004513B1 (pt) |
| ES (1) | ES2183650T3 (pt) |
| HU (1) | HU228681B1 (pt) |
| IL (1) | IL142181A (pt) |
| MX (1) | MXPA01003377A (pt) |
| NO (1) | NO317305B1 (pt) |
| NZ (1) | NZ510748A (pt) |
| PL (1) | PL199434B1 (pt) |
| SK (1) | SK283729B6 (pt) |
| WO (1) | WO2000020430A1 (pt) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7078391B2 (en) * | 1997-02-10 | 2006-07-18 | Inspire Pharmaceuticals, Inc. | Method of treating edematous retinal disorders |
| US6818629B2 (en) | 1997-02-10 | 2004-11-16 | Inspire Pharmaceuticals, Inc. | Pharmaceutical formulation comprising P1-(2'-deoxycytidine 5'-)P4-(uridine 5'-) tetraphosphate |
| US7223744B2 (en) | 1997-02-10 | 2007-05-29 | Inspire Pharmaceuticals, Inc. | Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof |
| US6872710B2 (en) | 1997-07-25 | 2005-03-29 | Inspire Pharmaceuticals, Inc. | Di(uridine 5′)-tetraphosphate and salts thereof |
| PL202176B1 (pl) * | 1999-06-30 | 2009-06-30 | Yamasa Corp | Sposób wytwarzania P¹-(2'-deoksycytydyno-5')-P⁴-(urydyno-5')czterofosforanu |
| US6867199B2 (en) | 2000-08-21 | 2005-03-15 | Inspire Pharmaceuticals, Inc. | Dinucleoside polyphosphate compositions and their therapeutic use |
| CN100363376C (zh) * | 2006-06-12 | 2008-01-23 | 南京工业大学 | 一种5’-核苷三磷酸钠盐的结晶方法 |
| JPWO2017002827A1 (ja) * | 2015-06-29 | 2018-04-26 | ヤマサ醤油株式会社 | Ｐ１，ｐ４−ビス（５’−ウリジル）テトラホスフェート結晶の保管方法 |
| US10815263B2 (en) | 2016-10-25 | 2020-10-27 | Yamasa Corporation | Method for purifying P1,P4-di(uridine 5′-)tetraphosphate |
| KR20180091689A (ko) | 2017-11-06 | 2018-08-16 | 주식회사 종근당 | 무정형 디뉴클레오사이드 폴리포스페이트 화합물의 제조방법 |
| CN109021049B (zh) * | 2018-06-14 | 2020-12-08 | 扬子江药业集团北京海燕药业有限公司 | 一种尿苷5′-二磷酸-苯并咪唑二钠的合成方法 |
| KR20210110055A (ko) * | 2020-02-28 | 2021-09-07 | 주식회사 종근당바이오 | P1, p4-디(우리딘 5'-)테트라포스페이트 나트륨염 4 수화물 결정형 a의 제조방법 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6423694B1 (en) * | 1996-02-21 | 2002-07-23 | Inspire Pharmaceuticals, Inc. | Method of treating otitis media with uridine triphosphates and related compounds |
| DE69736468T2 (de) * | 1996-03-27 | 2007-03-29 | Inspire Pharmaceuticals, Inc. | Verfahren zur behandlung der ziliardyskinesie mit uridintriphosphaten und verwandten verbindungen |
| US6319908B1 (en) * | 1996-07-03 | 2001-11-20 | Inspire Pharmaceuticals, Inc. | Method for large-scale production of di(uridine 5′-tetraphosphate) and salts thereof |
| US5763447C1 (en) * | 1996-07-23 | 2002-05-07 | Inspire Pharmaceuticals | Method of preventing or treating pneumonia in immobilized patients with uridine triphosphates and related compounds |
| BRPI9810436B1 (pt) * | 1997-07-25 | 2015-12-29 | Inspire Pharmaceuticals Inc | processo para a produção em larga escala de di (5'-tetrafosfato de uridina) e sais do mesmo |
-
1999
- 1999-10-01 ES ES99970090T patent/ES2183650T3/es not_active Expired - Lifetime
- 1999-10-01 SK SK440-2001A patent/SK283729B6/sk not_active IP Right Cessation
- 1999-10-01 EA EA200200695A patent/EA004513B1/ru not_active IP Right Cessation
- 1999-10-01 JP JP2000574541A patent/JP3247685B2/ja not_active Expired - Lifetime
- 1999-10-01 US US09/582,642 patent/US6458946B1/en not_active Expired - Lifetime
- 1999-10-01 CN CNB2003101209181A patent/CN100396692C/zh not_active Expired - Lifetime
- 1999-10-01 CN CNB998117137A patent/CN1151166C/zh not_active Expired - Lifetime
- 1999-10-01 BR BR9914453-0A patent/BR9914453A/pt not_active Application Discontinuation
- 1999-10-01 AU AU60008/99A patent/AU747096C/en not_active Expired
- 1999-10-01 CA CA002345624A patent/CA2345624C/en not_active Expired - Lifetime
- 1999-10-01 IL IL14218199A patent/IL142181A/xx not_active IP Right Cessation
- 1999-10-01 MX MXPA01003377A patent/MXPA01003377A/es active IP Right Grant
- 1999-10-01 PL PL347070A patent/PL199434B1/pl unknown
- 1999-10-01 CZ CZ20011028A patent/CZ300402B6/cs not_active IP Right Cessation
- 1999-10-01 AT AT99970090T patent/ATE222920T1/de not_active IP Right Cessation
- 1999-10-01 NZ NZ510748A patent/NZ510748A/xx not_active IP Right Cessation
- 1999-10-01 KR KR10-2001-7004083A patent/KR100475008B1/ko active IP Right Grant
- 1999-10-01 WO PCT/JP1999/005415 patent/WO2000020430A1/ja active IP Right Grant
- 1999-10-01 BR BRPI9917911A patent/BRPI9917911B1/pt active IP Right Grant
- 1999-10-01 DE DE69902624T patent/DE69902624T2/de not_active Expired - Lifetime
- 1999-10-01 EP EP99970090A patent/EP1043329B1/en not_active Expired - Lifetime
- 1999-10-01 HU HU0103754A patent/HU228681B1/hu unknown
- 1999-10-01 EA EA200100407A patent/EA003167B1/ru not_active IP Right Cessation
-
2001
- 2001-03-30 NO NO20011634A patent/NO317305B1/no not_active IP Right Cessation
- 2001-08-06 JP JP2001237293A patent/JP3824894B2/ja not_active Expired - Lifetime
-
2002
- 2002-04-12 US US10/120,367 patent/US6780988B2/en not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) DA LPI |
|
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |