ATE222920T1 - Ein kristall von diuridine tetraphosphat oder ein solches salz und verfahren zu seiner herstellung, verfahren und herstellung der vorgenannten zusammensetzung - Google Patents

Ein kristall von diuridine tetraphosphat oder ein solches salz und verfahren zu seiner herstellung, verfahren und herstellung der vorgenannten zusammensetzung

Info

Publication number
ATE222920T1
ATE222920T1 AT99970090T AT99970090T ATE222920T1 AT E222920 T1 ATE222920 T1 AT E222920T1 AT 99970090 T AT99970090 T AT 99970090T AT 99970090 T AT99970090 T AT 99970090T AT E222920 T1 ATE222920 T1 AT E222920T1
Authority
AT
Austria
Prior art keywords
salt
ump
production
ppi
dpp
Prior art date
Application number
AT99970090T
Other languages
English (en)
Inventor
Hideaki Maeda
Toshio Yamada
Hiroshi Sato
Yutaka Noda
Original Assignee
Yamasa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Corp filed Critical Yamasa Corp
Application granted granted Critical
Publication of ATE222920T1 publication Critical patent/ATE222920T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT99970090T 1998-10-02 1999-10-01 Ein kristall von diuridine tetraphosphat oder ein solches salz und verfahren zu seiner herstellung, verfahren und herstellung der vorgenannten zusammensetzung ATE222920T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP28166398 1998-10-02
JP17068199 1999-06-17
PCT/JP1999/005415 WO2000020430A1 (fr) 1998-10-02 1999-10-01 Cristal de diuridine tetraphosphate ou sel correspondant et procede de fabrication

Publications (1)

Publication Number Publication Date
ATE222920T1 true ATE222920T1 (de) 2002-09-15

Family

ID=26493605

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99970090T ATE222920T1 (de) 1998-10-02 1999-10-01 Ein kristall von diuridine tetraphosphat oder ein solches salz und verfahren zu seiner herstellung, verfahren und herstellung der vorgenannten zusammensetzung

Country Status (21)

Country Link
US (2) US6458946B1 (de)
EP (1) EP1043329B1 (de)
JP (2) JP3247685B2 (de)
KR (1) KR100475008B1 (de)
CN (2) CN100396692C (de)
AT (1) ATE222920T1 (de)
AU (1) AU747096C (de)
BR (2) BRPI9917911B1 (de)
CA (1) CA2345624C (de)
CZ (1) CZ300402B6 (de)
DE (1) DE69902624T2 (de)
EA (2) EA004513B1 (de)
ES (1) ES2183650T3 (de)
HU (1) HU228681B1 (de)
IL (1) IL142181A (de)
MX (1) MXPA01003377A (de)
NO (1) NO317305B1 (de)
NZ (1) NZ510748A (de)
PL (1) PL199434B1 (de)
SK (1) SK283729B6 (de)
WO (1) WO2000020430A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7078391B2 (en) * 1997-02-10 2006-07-18 Inspire Pharmaceuticals, Inc. Method of treating edematous retinal disorders
US7223744B2 (en) * 1997-02-10 2007-05-29 Inspire Pharmaceuticals, Inc. Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof
US6818629B2 (en) 1997-02-10 2004-11-16 Inspire Pharmaceuticals, Inc. Pharmaceutical formulation comprising P1-(2'-deoxycytidine 5'-)P4-(uridine 5'-) tetraphosphate
US6872710B2 (en) 1997-07-25 2005-03-29 Inspire Pharmaceuticals, Inc. Di(uridine 5′)-tetraphosphate and salts thereof
CZ303172B6 (cs) * 1999-06-30 2012-05-09 Inspire Pharmaceuticals, Inc. Krystalická forma P1-(2'-deoxycytidin-5'-)P4-(uridin-5'-)tetrafosfátu
US6867199B2 (en) 2000-08-21 2005-03-15 Inspire Pharmaceuticals, Inc. Dinucleoside polyphosphate compositions and their therapeutic use
CN100363376C (zh) * 2006-06-12 2008-01-23 南京工业大学 一种5’-核苷三磷酸钠盐的结晶方法
WO2017002827A1 (ja) * 2015-06-29 2017-01-05 ヤマサ醤油株式会社 Ｐ１，ｐ４－ビス（５'－ウリジル）テトラホスフェート結晶の保管方法
EP3546472B1 (de) 2016-10-25 2021-06-16 Yamasa Corporation Verfahren zur reinigung von p1,p4-di(uridin 5'-)tetraphosphat
KR20180091689A (ko) * 2017-11-06 2018-08-16 주식회사 종근당 무정형 디뉴클레오사이드 폴리포스페이트 화합물의 제조방법
CN109021049B (zh) * 2018-06-14 2020-12-08 扬子江药业集团北京海燕药业有限公司 一种尿苷5′-二磷酸-苯并咪唑二钠的合成方法
KR20210110055A (ko) * 2020-02-28 2021-09-07 주식회사 종근당바이오 P1, p4-디(우리딘 5'-)테트라포스페이트 나트륨염 4 수화물 결정형 a의 제조방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6423694B1 (en) * 1996-02-21 2002-07-23 Inspire Pharmaceuticals, Inc. Method of treating otitis media with uridine triphosphates and related compounds
CN1229114C (zh) * 1996-03-27 2005-11-30 印斯拜尔药品股份有限公司 用三磷酸尿苷和相关化合物治疗纤毛运动障碍的方法
US6319908B1 (en) * 1996-07-03 2001-11-20 Inspire Pharmaceuticals, Inc. Method for large-scale production of di(uridine 5′-tetraphosphate) and salts thereof
US5763447C1 (en) * 1996-07-23 2002-05-07 Inspire Pharmaceuticals Method of preventing or treating pneumonia in immobilized patients with uridine triphosphates and related compounds
JP3723227B2 (ja) * 1997-07-25 2005-12-07 インスパイアー ファーマシューティカルズ，インコーポレイティド ジ（ウリジン５’）−テトラホスフェート及びその塩の大規模生産のための方法

Also Published As

Publication number Publication date
US6780988B2 (en) 2004-08-24
NZ510748A (en) 2002-10-25
AU747096B2 (en) 2002-05-09
KR100475008B1 (ko) 2005-03-08
PL199434B1 (pl) 2008-09-30
SK4402001A3 (en) 2001-11-06
NO317305B1 (no) 2004-10-04
HUP0103754A2 (hu) 2002-04-29
CA2345624A1 (en) 2000-04-13
NO20011634D0 (no) 2001-03-30
EA200200695A1 (ru) 2002-10-31
BRPI9917911B1 (pt) 2016-08-23
IL142181A0 (en) 2002-03-10
HU228681B1 (en) 2013-05-28
BR9914453A (pt) 2001-05-22
CN1502622A (zh) 2004-06-09
US20020156269A1 (en) 2002-10-24
WO2000020430A1 (fr) 2000-04-13
AU6000899A (en) 2000-04-26
CZ20011028A3 (cs) 2001-08-15
JP2002053590A (ja) 2002-02-19
EP1043329A4 (de) 2001-03-14
DE69902624T2 (de) 2003-04-03
ES2183650T3 (es) 2003-03-16
EP1043329A1 (de) 2000-10-11
EA004513B1 (ru) 2004-04-29
KR20020013471A (ko) 2002-02-20
EA200100407A1 (ru) 2001-10-22
DE69902624D1 (de) 2002-10-02
EP1043329B1 (de) 2002-08-28
AU747096C (en) 2003-01-23
HUP0103754A3 (en) 2003-01-28
CZ300402B6 (cs) 2009-05-13
CN100396692C (zh) 2008-06-25
US6458946B1 (en) 2002-10-01
JP3824894B2 (ja) 2006-09-20
SK283729B6 (sk) 2003-12-02
CA2345624C (en) 2006-12-05
MXPA01003377A (es) 2003-06-24
IL142181A (en) 2005-12-18
EA003167B1 (ru) 2003-02-27
CN1321163A (zh) 2001-11-07
PL347070A1 (en) 2002-03-11
CN1151166C (zh) 2004-05-26
JP3247685B2 (ja) 2002-01-21
NO20011634L (no) 2001-05-30

Similar Documents

Publication Publication Date Title
ATE222920T1 (de) Ein kristall von diuridine tetraphosphat oder ein solches salz und verfahren zu seiner herstellung, verfahren und herstellung der vorgenannten zusammensetzung
NO20016381D0 (no) Dinukleotidkrystaller
RU94046317A (ru) Новое синтетическое промежуточное соединение для получения производных и способы получения производных аминокислот
DE60231534D1 (de) Kristall von oxidiertem glutathion und verfahren zu dessen herstellung
BG60314B2 (en) Method for producing ceramic and composition ceramic articles
MY107160A (en) N-aryl-3-aryl-4-substituted-4,5-dihydro-1h-pyrazole-1- carboxamides and processes for their production.
DE50007399D1 (de) Verfahren zur kontinuierlichen herstellung von glutaraldehyd
HUP0402545A2 (hu) Acetil-L-karnitin szerves dikarbonsavval alkotott sója és eljárás előállítására
DE69629661D1 (de) VERFAHREN ZUR HERSTELLUNG VON N-(D-alpha-METHYL-beta-MERCAPTOPROPIONYL)-L-PROLIN UND INTERMEDIATEN DAVON
JPH0641463B2 (ja) チオテトロン酸の製造方法
DE69926223D1 (de) Verfahren zur herstellung von zwischenprodukten
DE69604565T2 (de) Verfahren zur herstellung von polycyanatestern
HUP9801658A2 (hu) Eljárás az 1. típusú ranitidin hidroklorid előállítására és az ezzel az eljárással előállítható termék
JP2000229940A (ja) 高純度ピロリドン類の製造法
JPH02282376A (ja) シス―７―デセン―４―オリドの製造方法
JPS63203673A (ja) Ｄｌ−パントラクトンの光学分割法
JPH0616614A (ja) ニトリルの製造法
JPS61134368A (ja) Ｎ−クロルスルフェニル化合物の製造方法
JPH041164A (ja) ２―アセトアミドチロイノシトール類およびその製造方法
JPS60243057A (ja) 光学活性有機イソシアネート類の製造法
JPH07149712A (ja) ジフェニルジスルホニルフルオライドおよびその合成方法
RU95101529A (ru) СПОСОБ ПОЛУЧЕНИЯ N-( α -АЛКОКСИЭТИЛ)КАПРОЛАКТАМОВ

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties