DE69624235T2 - Derivate der epoxybernsteinsäure - Google Patents

Derivate der epoxybernsteinsäure

Info

Publication number
DE69624235T2
DE69624235T2 DE69624235T DE69624235T DE69624235T2 DE 69624235 T2 DE69624235 T2 DE 69624235T2 DE 69624235 T DE69624235 T DE 69624235T DE 69624235 T DE69624235 T DE 69624235T DE 69624235 T2 DE69624235 T2 DE 69624235T2
Authority
DE
Germany
Prior art keywords
aralkyl
alkyl
aryl
derivatives
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69624235T
Other languages
English (en)
Other versions
DE69624235D1 (de
Inventor
Yutaka Nomura
Toshihiro Takahashi
Kaoru Hara
Yasushi Yoshino
Mitsuo Masaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Chemiphar Co Ltd
Original Assignee
Nippon Chemiphar Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemiphar Co Ltd filed Critical Nippon Chemiphar Co Ltd
Application granted granted Critical
Publication of DE69624235D1 publication Critical patent/DE69624235D1/de
Publication of DE69624235T2 publication Critical patent/DE69624235T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D303/46—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by amide or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Resins (AREA)
DE69624235T 1995-03-31 1996-04-01 Derivate der epoxybernsteinsäure Expired - Lifetime DE69624235T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10050495 1995-03-31
PCT/JP1996/000889 WO1996030354A1 (fr) 1995-03-31 1996-04-01 Derives d'acide epoxysuccinique

Publications (2)

Publication Number Publication Date
DE69624235D1 DE69624235D1 (de) 2002-11-14
DE69624235T2 true DE69624235T2 (de) 2003-06-26

Family

ID=14275780

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69624235T Expired - Lifetime DE69624235T2 (de) 1995-03-31 1996-04-01 Derivate der epoxybernsteinsäure

Country Status (13)

Country Link
US (1) US5843992A (de)
EP (1) EP0826681B1 (de)
KR (1) KR100381275B1 (de)
CN (1) CN1087295C (de)
AT (1) ATE225781T1 (de)
AU (1) AU716620B2 (de)
CA (1) CA2217051C (de)
DE (1) DE69624235T2 (de)
DK (1) DK0826681T3 (de)
EA (1) EA000438B1 (de)
ES (1) ES2184855T3 (de)
PT (1) PT826681E (de)
WO (1) WO1996030354A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998000422A1 (en) * 1996-07-02 1998-01-08 Sang Sup Jew Oxirane carboxylic acid derivative and its manufacturing method
PL335478A1 (en) * 1997-02-26 2000-04-25 Lilly Co Eli Method of obtaining pharmaceutic compounds
AU8997898A (en) 1997-09-04 1999-03-22 Nippon Chemiphar Co. Ltd. Epoxysuccinamide derivatives
US20070203073A1 (en) * 2005-06-22 2007-08-30 Diamond Scott L SARS and Ebola inhibitors and use thereof, and methods for their discovery
US20080227806A1 (en) * 2005-09-28 2008-09-18 American Life Science Pharmaceuticals Novel Drugs for Dementia
JP2010503610A (ja) * 2006-05-22 2010-02-04 ベルキュラ セラピューティクス インコーポレイティッド 骨産生におけるカテプシンｋアンタゴニストの使用
US20100216875A1 (en) * 2006-12-20 2010-08-26 Gregory Hook Methods of treating alzheimer's disease
EP2168600A1 (de) 2007-06-08 2010-03-31 Nippon Chemiphar Co., Ltd. Therapeutisches oder prophylaktisches mittel für ein zerebralaneurysma
US20100331545A1 (en) 2007-10-24 2010-12-30 Nippon Chemiphar Co., Ltd. Regulator for signaling toll-like receptor, which comprises cathepsin inhibitor as active ingredient
RU2756956C2 (ru) * 2020-03-26 2021-10-07 Публичное акционерное общество «СИБУР Холдинг» Способ получения кристаллической формы цис-2,3-эпоксисукцината кальция

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5547668A (en) * 1978-09-30 1980-04-04 Taisho Pharmaceut Co Ltd Epoxysuccinamic acid
US4418705A (en) * 1979-05-22 1983-12-06 G. D. Societa Per Azioni Method and relative manufacturing machine for simultaneously producing two continuous cigarette rods
EP0269311A3 (de) * 1986-11-17 1990-06-06 Merck & Co. Inc. Methoden zur Behandlung von Knochenleiden mittels Verabreichung von Cystein-Proteinaseinhibitoren
AU5123196A (en) * 1995-03-31 1996-10-16 Nippon Chemiphar Co. Ltd. Bisphosphonic acid derivatives
US5733911A (en) * 1996-01-26 1998-03-31 Hitachi Chemical Co., Ltd. Method for inducing death of neoplastic cells using piperazne derivatives

Also Published As

Publication number Publication date
CA2217051C (en) 2006-05-30
EA000438B1 (ru) 1999-08-26
DK0826681T3 (da) 2003-02-17
ATE225781T1 (de) 2002-10-15
WO1996030354A1 (fr) 1996-10-03
PT826681E (pt) 2003-02-28
ES2184855T3 (es) 2003-04-16
EP0826681A1 (de) 1998-03-04
KR100381275B1 (ko) 2003-08-19
CA2217051A1 (en) 1996-10-03
AU716620B2 (en) 2000-03-02
CN1185151A (zh) 1998-06-17
KR19980703485A (ko) 1998-11-05
DE69624235D1 (de) 2002-11-14
US5843992A (en) 1998-12-01
EP0826681B1 (de) 2002-10-09
AU5123296A (en) 1996-10-16
CN1087295C (zh) 2002-07-10
EP0826681A4 (de) 1998-03-18
EA199800181A1 (ru) 1998-08-27

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition