AR024390A1 - Nuevos compuestos - Google Patents
Nuevos compuestosInfo
- Publication number
- AR024390A1 AR024390A1 ARP000103010A ARP000103010A AR024390A1 AR 024390 A1 AR024390 A1 AR 024390A1 AR P000103010 A ARP000103010 A AR P000103010A AR P000103010 A ARP000103010 A AR P000103010A AR 024390 A1 AR024390 A1 AR 024390A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkoxy
- compound
- independently
- unsubstituted
- hydroxy
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Un compuesto de la formula (1) o una de sus sales, o uno de sus solvatos, en la que: R1 y R2 cada uno independientemente, representa alcoxi C1-6 o halo; R3y R4 cada uno independientemente, representan hidrogeno, alcoxi C1-6, arilalcoxi C1-6,hidroxi, carboxi-alcoxi C1-6, hidroxi-alcoxi C1-6, dihidroxi-alcoxi C1-6, mono- y di alquil C1-6-amino-alcooxi C1-6 o amino-alcoxi C1-6 y R5 representa -NRsRt, cada uno independientemente representanhidrogeno, alquilo C1-6 sustituido o nosustituido, o heter ociclilo sustituido o no sustituido, un procedimiento para la preparacion de dicho compuesto, unacomposicion farmacéutica que contiene dicho compuesto y el uso del compuesto o de la composicion en medicina. Los compuestos actuaninhibiendo selectivam entela actividad de los osteoclastos en la resorcion osea.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9914371.1A GB9914371D0 (en) | 1999-06-18 | 1999-06-18 | Novel compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
AR024390A1 true AR024390A1 (es) | 2002-10-02 |
Family
ID=10855696
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP000103010A AR024390A1 (es) | 1999-06-18 | 2000-06-16 | Nuevos compuestos |
Country Status (30)
Country | Link |
---|---|
US (2) | US6787550B1 (es) |
EP (1) | EP1212317B1 (es) |
JP (1) | JP2003503490A (es) |
KR (1) | KR100701109B1 (es) |
CN (1) | CN1179960C (es) |
AR (1) | AR024390A1 (es) |
AT (1) | ATE276245T1 (es) |
AU (1) | AU768726B2 (es) |
BR (1) | BR0011708A (es) |
CA (1) | CA2376657A1 (es) |
CO (1) | CO5200757A1 (es) |
CZ (1) | CZ301697B6 (es) |
DE (1) | DE60013859T2 (es) |
DK (1) | DK1212317T3 (es) |
ES (1) | ES2226870T3 (es) |
GB (1) | GB9914371D0 (es) |
GC (1) | GC0000341A (es) |
HK (2) | HK1048468B (es) |
HU (1) | HUP0202049A3 (es) |
IL (2) | IL147012A0 (es) |
MX (1) | MXPA01013277A (es) |
MY (1) | MY129425A (es) |
NO (1) | NO322313B1 (es) |
NZ (1) | NZ516131A (es) |
PL (1) | PL352964A1 (es) |
PT (1) | PT1212317E (es) |
TR (1) | TR200103683T2 (es) |
TW (1) | TWI248440B (es) |
WO (1) | WO2001002388A1 (es) |
ZA (1) | ZA200200177B (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7615575B2 (en) | 2003-02-13 | 2009-11-10 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
AU2004259703A1 (en) * | 2003-07-15 | 2005-02-03 | Smithkline Beecham Corporation | Novel compounds |
ITMI20040875A1 (it) * | 2004-04-30 | 2004-07-30 | Ist Naz Stud Cura Dei Tumori | Derivati indolici utili per il trattamento della resistenza agli agenti antitumorali |
EP1799696B1 (en) | 2004-09-17 | 2008-11-12 | IDENIX Pharmaceuticals, Inc. | Phosphoindoles as hiv inhibitors |
WO2006041874A2 (en) * | 2004-10-04 | 2006-04-20 | Myriad Genetics, Inc. | Compounds for alzheimer's disease |
US7833805B2 (en) * | 2004-10-21 | 2010-11-16 | University Of Cincinnati | Selectively permeable membranes on porous substrates |
JP5070050B2 (ja) * | 2005-07-20 | 2012-11-07 | 正徳 染井 | トリプトファン誘導体及びその用途 |
ITRM20050389A1 (it) | 2005-07-22 | 2007-01-23 | Giuliani Spa | Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico. |
ITRM20050390A1 (it) | 2005-07-22 | 2007-01-23 | Giuliani Spa | Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico. |
BRPI0616994A2 (pt) * | 2005-08-15 | 2011-07-05 | Irm Llc | compostos e composições como miméticos de tpo |
EP1779849A1 (en) * | 2005-10-28 | 2007-05-02 | Nikem Research S.R.L. | V-ATPase inhibitors for the treatment of septic shock |
EP1779848A1 (en) * | 2005-10-28 | 2007-05-02 | Nikem Research S.R.L. | V-ATPase inhibitors for the treatment of inflammatory and autoimmune diseases |
CA2637375A1 (en) | 2006-01-25 | 2007-08-02 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
CA2637373A1 (en) | 2006-01-25 | 2007-08-02 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
CN101378740A (zh) | 2006-02-02 | 2009-03-04 | 维尔斯达医疗公司 | 用于治疗代谢紊乱的化合物 |
WO2008008887A2 (en) * | 2006-07-13 | 2008-01-17 | Smithkline Beecham Corporation | Gpr119 agonists for treating metabolic disorders |
AU2007305447A1 (en) | 2006-09-29 | 2008-04-10 | Idenix Pharmaceuticals, Inc | Enantiomerically pure phosphoindoles as HIV inhibitors |
UA107562C2 (uk) | 2008-12-05 | 2015-01-26 | Спосіб лікування псоріазу | |
PT2396081T (pt) | 2009-02-16 | 2017-07-11 | Nogra Pharma Ltd | Compostos alquilamido e suas utilizações |
WO2010144611A2 (en) * | 2009-06-10 | 2010-12-16 | 3-V Biosciences, Inc. | Antivirals that target transporters, carriers, and ion channels |
PL2614052T3 (pl) | 2010-09-08 | 2015-06-30 | Bristol Myers Squibb Co | Nowe analogi piperazyny jako środki przeciw wirusowi grypy o szerokim spektrum |
WO2012045451A1 (en) | 2010-10-05 | 2012-04-12 | Ludwig-Maximilians-Universitaet Muenchen | Novel therapeutic treatment of progranulin-dependent diseases |
WO2012078416A2 (en) * | 2010-12-06 | 2012-06-14 | Rfs Pharma, Llc | Monophosphate prodrugs of dapd and analogs thereof |
CA2864059C (en) | 2012-02-09 | 2020-04-28 | Nogra Pharma Limited | Methods of treating fibrosis |
BR112014026160A2 (pt) | 2012-04-18 | 2017-07-18 | Nogra Pharma Ltd | métodos para tratar intolerância à lactose |
EA202192207A1 (ru) | 2019-02-08 | 2021-10-27 | Ногра Фарма Лимитед | Способ получения 3-(4'-аминофенил)-2-метоксипропионовой кислоты и ее аналогов и промежуточных соединений |
CN113024432A (zh) * | 2019-12-24 | 2021-06-25 | 上海科胜药物研发有限公司 | 一种氨磺必利药典杂质的制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2124511C1 (ru) * | 1993-05-14 | 1999-01-10 | Фармасьютикал Ко., Лтд | Производные пиперазина |
TR199700625T1 (xx) * | 1995-01-10 | 1998-02-21 | Smithkline Beecham S.P.A. | Osteoporoz (kemik erimesi) tedavisinde yararl� olan indol t�revleri. |
AU3620597A (en) | 1996-07-09 | 1998-02-02 | Smithkline Beecham Laboratoires Pharmaceutiques | Indole derivatives for the treatment of osteoporosis |
CN1208333C (zh) | 1997-12-24 | 2005-06-29 | Nikem研究有限公司 | 主要用于治疗骨质疏松的吲哚衍生物 |
-
1999
- 1999-06-18 GB GBGB9914371.1A patent/GB9914371D0/en not_active Ceased
-
2000
- 2000-06-16 TR TR2001/03683T patent/TR200103683T2/xx unknown
- 2000-06-16 KR KR1020017016180A patent/KR100701109B1/ko not_active IP Right Cessation
- 2000-06-16 US US10/018,443 patent/US6787550B1/en not_active Expired - Fee Related
- 2000-06-16 PT PT00943839T patent/PT1212317E/pt unknown
- 2000-06-16 EP EP00943839A patent/EP1212317B1/en not_active Expired - Lifetime
- 2000-06-16 CA CA002376657A patent/CA2376657A1/en not_active Abandoned
- 2000-06-16 WO PCT/EP2000/005672 patent/WO2001002388A1/en active IP Right Grant
- 2000-06-16 DE DE60013859T patent/DE60013859T2/de not_active Expired - Lifetime
- 2000-06-16 JP JP2001507825A patent/JP2003503490A/ja active Pending
- 2000-06-16 BR BR0011708-0A patent/BR0011708A/pt not_active IP Right Cessation
- 2000-06-16 CN CNB008115974A patent/CN1179960C/zh not_active Expired - Fee Related
- 2000-06-16 PL PL00352964A patent/PL352964A1/xx not_active IP Right Cessation
- 2000-06-16 MX MXPA01013277A patent/MXPA01013277A/es active IP Right Grant
- 2000-06-16 AU AU58165/00A patent/AU768726B2/en not_active Ceased
- 2000-06-16 DK DK00943839T patent/DK1212317T3/da active
- 2000-06-16 HU HU0202049A patent/HUP0202049A3/hu unknown
- 2000-06-16 AT AT00943839T patent/ATE276245T1/de not_active IP Right Cessation
- 2000-06-16 AR ARP000103010A patent/AR024390A1/es not_active Application Discontinuation
- 2000-06-16 MY MYPI20002728A patent/MY129425A/en unknown
- 2000-06-16 CO CO00045017A patent/CO5200757A1/es not_active Application Discontinuation
- 2000-06-16 CZ CZ20014496A patent/CZ301697B6/cs not_active IP Right Cessation
- 2000-06-16 ES ES00943839T patent/ES2226870T3/es not_active Expired - Lifetime
- 2000-06-16 IL IL14701200A patent/IL147012A0/xx active IP Right Grant
- 2000-06-16 NZ NZ516131A patent/NZ516131A/en unknown
- 2000-06-18 GC GCP2000726 patent/GC0000341A/en active
- 2000-07-06 TW TW089113348A patent/TWI248440B/zh not_active IP Right Cessation
-
2001
- 2001-12-10 IL IL147012A patent/IL147012A/en not_active IP Right Cessation
- 2001-12-17 NO NO20016149A patent/NO322313B1/no not_active IP Right Cessation
-
2002
- 2002-01-09 ZA ZA200200177A patent/ZA200200177B/en unknown
- 2002-11-19 HK HK02108380.9A patent/HK1048468B/zh not_active IP Right Cessation
-
2003
- 2003-02-20 HK HK03101303.7A patent/HK1049164A1/zh unknown
-
2004
- 2004-06-24 US US10/875,356 patent/US20040235930A1/en not_active Abandoned
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |