TR200103683T2 - Indol türevleri ve bu türevlerin diğer uygulamaların yanısıra osteoporoz tedavisinde kullanımı - Google Patents

Indol türevleri ve bu türevlerin diğer uygulamaların yanısıra osteoporoz tedavisinde kullanımı

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Publication number
TR200103683T2
TR200103683T2 TR2001/03683T TR200103683T TR200103683T2 TR 200103683 T2 TR200103683 T2 TR 200103683T2 TR 2001/03683 T TR2001/03683 T TR 2001/03683T TR 200103683 T TR200103683 T TR 200103683T TR 200103683 T2 TR200103683 T2 TR 200103683T2
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Turkey
Prior art keywords
6alkoxy
compound
osteoporosis
applications
treatment
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Application number
TR2001/03683T
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English (en)
Inventor
Farina Carlo
Gagliardi Stefania
A.T. Novella Pietro
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Glaxosmithkline S.P.A.
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Publication date
Application filed by Glaxosmithkline S.P.A. filed Critical Glaxosmithkline S.P.A.
Publication of TR200103683T2 publication Critical patent/TR200103683T2/tr

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    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P19/00Drugs for skeletal disorders
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    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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Abstract

R1 ve R2'nin her birinin bagimsiz olarak C1-6alkoksi veya halo; R3 ve R4'ün her birinin bagimsiz olarak hidrojen, C1-6alkoksi, arilC1-6alkoksi, hidroksi, karboksiC1-6alkoksi, karboksi C1-6alkoksi, hidroksiC1-6alkoksi, dihidroksiC1 -6alkoksi mono-and di-(C1-6alkil) amino C1-6alkoksi veya aminoC1-6alkoksi, ve; R5'in, Rs ve Rt'nin her birinin bagimsiz olarak hidrojen, ikame edilmemis veya ikame edilmis C1-6alkil veya ikame edilmemis veya ikame edilmis heterosiklil oldugu -NRsRt oldugu bir formül (I): bilesigi veya bunun bir tuzu ya da solvati; böyle bir bilesigin hazirlanmasi için bir proses, böyle bir bilesik içeren farmasötik bir terkip ve böyle bir bilesigin veya terkibin ilaçlardan kullanilmasi.
TR2001/03683T 1999-06-18 2000-06-16 Indol türevleri ve bu türevlerin diğer uygulamaların yanısıra osteoporoz tedavisinde kullanımı TR200103683T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9914371.1A GB9914371D0 (en) 1999-06-18 1999-06-18 Novel compounds

Publications (1)

Publication Number Publication Date
TR200103683T2 true TR200103683T2 (tr) 2003-01-21

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Application Number Title Priority Date Filing Date
TR2001/03683T TR200103683T2 (tr) 1999-06-18 2000-06-16 Indol türevleri ve bu türevlerin diğer uygulamaların yanısıra osteoporoz tedavisinde kullanımı

Country Status (30)

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US (2) US6787550B1 (tr)
EP (1) EP1212317B1 (tr)
JP (1) JP2003503490A (tr)
KR (1) KR100701109B1 (tr)
CN (1) CN1179960C (tr)
AR (1) AR024390A1 (tr)
AT (1) ATE276245T1 (tr)
AU (1) AU768726B2 (tr)
BR (1) BR0011708A (tr)
CA (1) CA2376657A1 (tr)
CO (1) CO5200757A1 (tr)
CZ (1) CZ301697B6 (tr)
DE (1) DE60013859T2 (tr)
DK (1) DK1212317T3 (tr)
ES (1) ES2226870T3 (tr)
GB (1) GB9914371D0 (tr)
GC (1) GC0000341A (tr)
HK (2) HK1049164A1 (tr)
HU (1) HUP0202049A3 (tr)
IL (2) IL147012A0 (tr)
MX (1) MXPA01013277A (tr)
MY (1) MY129425A (tr)
NO (1) NO322313B1 (tr)
NZ (1) NZ516131A (tr)
PL (1) PL352964A1 (tr)
PT (1) PT1212317E (tr)
TR (1) TR200103683T2 (tr)
TW (1) TWI248440B (tr)
WO (1) WO2001002388A1 (tr)
ZA (1) ZA200200177B (tr)

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AU2004212905B2 (en) 2003-02-13 2008-10-09 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
CA2532248A1 (en) * 2003-07-15 2005-02-03 Smithkline Beecham Corporation Novel compounds
ITMI20040875A1 (it) * 2004-04-30 2004-07-30 Ist Naz Stud Cura Dei Tumori Derivati indolici utili per il trattamento della resistenza agli agenti antitumorali
DE602005023360D1 (de) 2004-09-17 2010-10-14 Idenix Pharmaceuticals Inc Phosphoindole als HIV-Inhibitoren
CN101068781B (zh) * 2004-10-04 2012-02-01 美瑞德生物工程公司 用于阿尔茨海默氏病的化合物
US7833805B2 (en) * 2004-10-21 2010-11-16 University Of Cincinnati Selectively permeable membranes on porous substrates
JP5070050B2 (ja) * 2005-07-20 2012-11-07 正徳 染井 トリプトファン誘導体及びその用途
ITRM20050390A1 (it) 2005-07-22 2007-01-23 Giuliani Spa Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico.
ITRM20050389A1 (it) 2005-07-22 2007-01-23 Giuliani Spa Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico.
RU2385865C2 (ru) * 2005-08-15 2010-04-10 Айрм Ллк Соединения и композиции в качестве миметиков тро
EP1779849A1 (en) * 2005-10-28 2007-05-02 Nikem Research S.R.L. V-ATPase inhibitors for the treatment of septic shock
EP1779848A1 (en) 2005-10-28 2007-05-02 Nikem Research S.R.L. V-ATPase inhibitors for the treatment of inflammatory and autoimmune diseases
CA2637375A1 (en) 2006-01-25 2007-08-02 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
US7915429B2 (en) 2006-01-25 2011-03-29 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
WO2007092729A2 (en) 2006-02-02 2007-08-16 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
US8222261B2 (en) * 2006-07-13 2012-07-17 GlaxoSmithKline, LLC Chemical compounds
KR20090077813A (ko) 2006-09-29 2009-07-15 아이데닉스 파마슈티칼스, 인코포레이티드 Hiv 억제제로서의 거울상이성질체적으로 순수한 포스포인돌
UA107562C2 (uk) 2008-12-05 2015-01-26 Спосіб лікування псоріазу
KR101800901B1 (ko) 2009-02-16 2017-11-23 노그라 파마 리미티드 알킬아미도 화합물 및 그의 용도
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ES2533068T3 (es) * 2010-09-08 2015-04-07 Bristol-Myers Squibb Company Nuevos análogos de piperazina como antivirales de influenza de amplio espectro
WO2012045451A1 (en) 2010-10-05 2012-04-12 Ludwig-Maximilians-Universitaet Muenchen Novel therapeutic treatment of progranulin-dependent diseases
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CN116602950A (zh) 2012-02-09 2023-08-18 诺格拉制药有限公司 治疗纤维化的方法
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WO2020161362A1 (en) 2019-02-08 2020-08-13 Nogra Pharma Limited Process of making 3-(4'-aminophenyl)-2-methoxypropionic acid, and analogs and intermediates thereof
CN113024432A (zh) * 2019-12-24 2021-06-25 上海科胜药物研发有限公司 一种氨磺必利药典杂质的制备方法

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SI1042316T1 (tr) * 1997-12-24 2005-08-31 Nikem Research Srl

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WO2001002388A1 (en) 2001-01-11
MXPA01013277A (es) 2002-06-04
CN1370159A (zh) 2002-09-18
AU768726B2 (en) 2004-01-08
AU5816500A (en) 2001-01-22
IL147012A (en) 2007-06-03
MY129425A (en) 2007-03-30
PT1212317E (pt) 2005-02-28
HUP0202049A3 (en) 2003-12-29
DK1212317T3 (da) 2005-01-24
AR024390A1 (es) 2002-10-02
CA2376657A1 (en) 2001-01-11
NO322313B1 (no) 2006-09-11
IL147012A0 (en) 2002-08-14
ES2226870T3 (es) 2005-04-01
HK1048468A1 (en) 2003-04-04
ATE276245T1 (de) 2004-10-15
CN1179960C (zh) 2004-12-15
CO5200757A1 (es) 2002-09-27
TWI248440B (en) 2006-02-01
GC0000341A (en) 2007-03-31
CZ301697B6 (cs) 2010-05-26
KR20020025079A (ko) 2002-04-03
DE60013859D1 (de) 2004-10-21
JP2003503490A (ja) 2003-01-28
US6787550B1 (en) 2004-09-07
DE60013859T2 (de) 2005-09-29
CZ20014496A3 (cs) 2002-07-17
GB9914371D0 (en) 1999-08-18
NO20016149D0 (no) 2001-12-17
EP1212317B1 (en) 2004-09-15
US20040235930A1 (en) 2004-11-25
HUP0202049A2 (hu) 2002-11-28
HK1049164A1 (zh) 2003-05-02
KR100701109B1 (ko) 2007-03-29
NO20016149L (no) 2001-12-17
ZA200200177B (en) 2003-09-23
EP1212317A1 (en) 2002-06-12
BR0011708A (pt) 2002-05-21
NZ516131A (en) 2003-10-31
PL352964A1 (en) 2003-09-22
HK1048468B (en) 2005-07-29

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