KR860004050A - 화학적 화합물 - Google Patents
화학적 화합물 Download PDFInfo
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- KR860004050A KR860004050A KR1019850008129A KR850008129A KR860004050A KR 860004050 A KR860004050 A KR 860004050A KR 1019850008129 A KR1019850008129 A KR 1019850008129A KR 850008129 A KR850008129 A KR 850008129A KR 860004050 A KR860004050 A KR 860004050A
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- pyridylmethylsulfinyl
- benzimidazole
- methoxy
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (8)
1) 다음 구조식(I)의 화합물을 제조하는 방법.
여기서 R1내지 R4는 같거나 다를수도 있고, 각 수소, 할로겐, 트리플루오로메틸, C1-6알킬, C1-6알콕시, C1-6알카노일 또는 C1-6알콕시카르보닐, RCF2O, 3 내지 5의 불소원자로 치환된 에톡시그룹이거나, R2및 R3는 함께 -O(CR2)mO-그룹을 형성한다; R는 수소 또는 불소이다; m는 1 또는 2이다; n은 0 또는 1이다; R5및 R6는 같거나 다를수도 있고 각 수소, C1-6알킬, 또는 C2-6사이클로알킬이거나 R5및 R6는 그 부가되어 있는 질소원자와 함께 아제티디노, 피롤리디노, 피페리디노, 피페라지노, N-C1-4알킬피페라지노 또는 모르폴리노-그룹을 형성한다; 그리고 R7과 R8중 하나는 할로겐, 다른 하나는 수소, 할로겐 또는 C1-6알킬이다. 또는 다음 반응을 포함하는 그 제약학적으로 바람직한 염의 제조방법;
a) 다음 구조식(II)의 화합물과 다음 구조식(III)의 화합물과의 반응.
위 구조식에서 R1내지 R8는 구조식(I)의 경우에서 기술한 바와같고, L1및 L2중 하나는 SH, 다른 하나는 메르캅탄에 의하여 치환 가능한 유리그룹이다.
b) 다음 구조식(IV)의 화합물과 다음 구조식(V)의 화합물과의 반응.
위 구조식에서, R1내지 R4는 구조식(I)의 경우에서 기술한 바와같다.
위 구조식에서 R5내지 R8은 구조식(I)의 경우에서 기술한 바와같고, X는 CO2H 또는 CSX1, X1은 할로겐 또는 C1-4알콕시이다.
c) 다음 구조식(VI)의 화합물과 다음 구조식(VII)의 화합물과의 반응.
위 구조식에서 R1내지 R4는 구조식(I)의 경우에서 기술한 바와같고, R9는 수소 또는 보호그룹, M은 금속원자이다.
위 구조식에서 R5내지 R8은 구조식(I)의 경우에서 기술한 바와같고 Z는 유리그룹, P는 0 또는 1이다.
d) 다음 구조식(VIII)의 화합물과 다음 구조식(IX)의 화합물과의 반응.
위 구조식에서 R1내지 R4는 구조식(I)의 경우에서 기술한 바와같고, R9는 수소 또는 보호그룹, Y는 유리그룹이다.
여기에서, R5내지 R8은 구조식(I)의 경우에서 기술한 바와같고, P는 0 또는 1,M7는 금속원자에 상응하는 물질이다.
아울러 바람직한 경우 선택적으로 실시될수 있는 다음 반응을 포함한다.
(i) n이 0인 구조식(I)의 화합물을 n이 1구조식(I)의 화합물로 산화시키는 반응.
(ii) n이 1로서 형성된 구조식(I)의 화합물을 n이 0인 구조식(I)의 화합물로 환원시키는 반응.
(iii) 제약학적으로 바람직한 염을 형성하는 반응.
L1이 SH이고 L2가 유리그룹인 청구범위 1의 방법.
L2가 염소인 청구범위 2의 방법.
R5및 R8가 그 부가되어 있는 질소원자와 함께 피롤리디노, 피페리디노, 피페라지노, N-C1-4알킬 피페라지노 또는 모르폴리노그룹인 구조식(I)의 화합물을 제조하기 위하여 사용되는 청구범위 1내지 3이 방법.
다음 화합물을 제조하기 위하여 사용되는 청구범위 1의 방법
2-(5-브로모-4-피페리디노-2-피리딜메틸설피닐)-5-메톡시-(1H)-벤즈이미다졸,
2-(3-브로모-4-피페리디노-2-피리딜메틸설피닐)-5-메톡시-(1H)-벤즈이미다졸,
2-(3-클로로-4-피페리디노-2-피리딜메틸설피닐)-5-메톡시-(1H)-벤즈이미다졸,
2-(3-메틸-5-브로모-4-피페리디노-2-피리딜메틸설피닐)-5-메톡시-(1H)-벤즈이미다졸,
2-(3-클로로-5-메틸-4-피레리디노-2-피리딜메틸설피닐)-5-메톡시-(1H)-벤즈이미다졸,
2-(5-브로모-4-피롤리디노-2-피리딜메틸설피닐)-5-메톡시-(1H)-벤즈이미다졸,
2-(3-클로로-4-피롤리디노-2-피리딜메틸설피닐)-5-메톡시-(1H)-벤즈이미다졸,
2-(3-클로로-5-메틸-4-피롤리디노-2-피리딜메틸설피닐)-5-메톡시-(1H)-벤즈이미다졸,
2-(3-클로로-4-모르폴리노 2-피리딜메틸설피닐)-5-메톡시-(1H)-벤즈이미다졸,
2-(3-클로로-5-메틸-4-모르폴리노-2-피리딜메틸설피닐)-5-메톡시-(1H)-벤즈이미다졸,
2-(3-클로로-4-피페리디노-2-피리딜메틸설피닐)-5-(1,1,2,3-테트라플루오로에톡시)-(1H)-벤즈이미다졸,
2-(3-클로로-5-메틸-4-피페리디노-2-피리딜메틸설피닐)-4,5-디플루오로메틸렌디옥시-(1H)-벤즈이미다졸, 또는 그 제약학적으로 바람직한 염.
구조식(I)의 화합물 또는 그 제약학적으로 바람직한 염을 제약학적으로 바람직한 섭자와 결합시키는 것을 포함하는 제약학적 조합물의 제조방법.
구조식(I)의 화합물에서 n이 1인 청구범위 6의 방법.
그 조합물이 장용피에 미치는 청구범위 7의 방법.
※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB848427836A GB8427836D0 (en) | 1984-11-02 | 1984-11-02 | Chemical compounds |
GB8427836 | 1984-11-02 | ||
GB848432515A GB8432515D0 (en) | 1984-12-21 | 1984-12-21 | Heterocyclic compounds |
GB8432515 | 1984-12-21 | ||
GB858518043A GB8518043D0 (en) | 1985-07-17 | 1985-07-17 | Heterocyclic compounds |
GB8518043 | 1985-07-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR860004050A true KR860004050A (ko) | 1986-06-16 |
KR930001410B1 KR930001410B1 (ko) | 1993-02-27 |
Family
ID=27262502
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019850008129A KR930001410B1 (ko) | 1984-11-02 | 1985-11-01 | 치환된 벤즈이미다졸 유도체의 제조방법 |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0184322B1 (ko) |
KR (1) | KR930001410B1 (ko) |
CN (1) | CN1013445B (ko) |
AR (1) | AR241592A1 (ko) |
AU (1) | AU576634B2 (ko) |
CA (1) | CA1253150A (ko) |
DE (1) | DE3574873D1 (ko) |
DK (1) | DK501085A (ko) |
ES (1) | ES8701752A1 (ko) |
FI (1) | FI84718C (ko) |
GR (1) | GR852643B (ko) |
HU (1) | HU200763B (ko) |
IE (1) | IE58587B1 (ko) |
JO (1) | JO1406B1 (ko) |
NO (1) | NO164541C (ko) |
NZ (1) | NZ214024A (ko) |
PH (1) | PH22303A (ko) |
PT (1) | PT81420B (ko) |
ZW (1) | ZW19185A1 (ko) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
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EP0174717B1 (en) * | 1984-07-06 | 1992-01-22 | FISONS plc | Benzimidazoles, and their production formulation and use as gastric acid secretion inhibitors |
GB2161160B (en) * | 1984-07-06 | 1989-05-24 | Fisons Plc | Heterocyclic sulphinyl compounds |
GB8610607D0 (en) * | 1986-04-30 | 1986-06-04 | Smith Kline French Lab | Chemical compounds |
GB8621425D0 (en) * | 1986-09-05 | 1986-10-15 | Smith Kline French Lab | Compounds |
DE3722810A1 (de) * | 1987-07-10 | 1989-01-19 | Hoechst Ag | Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung |
US5668131A (en) * | 1993-12-01 | 1997-09-16 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Substituted aminoalkylaminopyridines |
IL146504A0 (en) | 1999-06-07 | 2002-07-25 | Byk Gulden Lomberg Chem Fab | Pharmaceutical compositions containing an acid-labile active compound and processes for the preparation thereof |
US7241890B2 (en) | 2001-10-30 | 2007-07-10 | Conforma Therapeutics Corporation | Purine analogs having HSP90-inhibiting activity |
US8802139B2 (en) | 2003-06-26 | 2014-08-12 | Intellipharmaceutics Corp. | Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient |
EP1670802A4 (en) | 2003-09-18 | 2010-07-07 | Conforma Therapeutics Corp | NOVEL HETEROCYCLIC COMPOUNDS AS INHIBITORS OF HSP90 PROTEIN |
US8394409B2 (en) | 2004-07-01 | 2013-03-12 | Intellipharmaceutics Corp. | Controlled extended drug release technology |
US10624858B2 (en) | 2004-08-23 | 2020-04-21 | Intellipharmaceutics Corp | Controlled release composition using transition coating, and method of preparing same |
EP1869027A4 (en) * | 2005-03-30 | 2010-06-23 | Conforma Therapeutics Corp | ALKYNYL-PYRROLOPYRIMIDINES AND CORRESPONDING ANALOGS AS HSP90 INHIBITORS |
US10064828B1 (en) | 2005-12-23 | 2018-09-04 | Intellipharmaceutics Corp. | Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems |
CN101453993A (zh) | 2006-04-03 | 2009-06-10 | 伊萨·奥迪迪 | 含有机溶胶涂层的受控释放递送物件 |
US10960077B2 (en) | 2006-05-12 | 2021-03-30 | Intellipharmaceutics Corp. | Abuse and alcohol resistant drug composition |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL66340A (en) * | 1981-08-13 | 1986-08-31 | Haessle Ab | Pharmaceutical compositions comprising pyridylmethyl-thiobenzimidazole derivatives,certain such novel derivatives and their preparation |
US4575554A (en) * | 1983-12-05 | 1986-03-11 | The Upjohn Company | Substituted 2-pyridylmethylthio- and sulfinyl-benzimidazoles as gastric antisecretory agents |
EP0174717B1 (en) * | 1984-07-06 | 1992-01-22 | FISONS plc | Benzimidazoles, and their production formulation and use as gastric acid secretion inhibitors |
EP0178438A1 (en) * | 1984-09-19 | 1986-04-23 | Beecham Group Plc | Novel compounds |
AU568441B2 (en) * | 1984-09-24 | 1987-12-24 | Upjohn Company, The | 2-(pyridylalkenesulfinyl) benzimidazole derivatives |
IL76837A0 (en) * | 1984-10-31 | 1986-02-28 | Byk Gulden Lomberg Chem Fab | Benzimidazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing them |
US4851419A (en) * | 1985-10-16 | 1989-07-25 | Fisons Plc | Certain 2-pyridinyl-phenylsulfinyl-benzoxazoles, the corresponding benzothiazoles or benzimidazoles having anti-inflammatory or gastric acid secretion inhibition activity |
EP0806002A1 (en) * | 1995-11-24 | 1997-11-12 | Koninklijke Philips Electronics N.V. | A method for presenting virtual reality enhanced with tactile stimuli, and a system for executing the method |
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1985
- 1985-10-24 JO JO19851406A patent/JO1406B1/en active
- 1985-10-28 CA CA000493978A patent/CA1253150A/en not_active Expired
- 1985-10-28 PH PH32987A patent/PH22303A/en unknown
- 1985-10-30 AU AU49207/85A patent/AU576634B2/en not_active Ceased
- 1985-10-30 AR AR85302116A patent/AR241592A1/es active
- 1985-10-30 ZW ZW191/85A patent/ZW19185A1/xx unknown
- 1985-10-30 FI FI854267A patent/FI84718C/fi not_active IP Right Cessation
- 1985-10-31 DK DK501085A patent/DK501085A/da not_active Application Discontinuation
- 1985-10-31 PT PT81420A patent/PT81420B/pt not_active IP Right Cessation
- 1985-10-31 DE DE8585307928T patent/DE3574873D1/de not_active Expired - Lifetime
- 1985-10-31 ES ES548409A patent/ES8701752A1/es not_active Expired
- 1985-10-31 EP EP85307928A patent/EP0184322B1/en not_active Expired
- 1985-10-31 NZ NZ214024A patent/NZ214024A/xx unknown
- 1985-11-01 HU HU854204A patent/HU200763B/hu not_active IP Right Cessation
- 1985-11-01 NO NO854369A patent/NO164541C/no unknown
- 1985-11-01 KR KR1019850008129A patent/KR930001410B1/ko not_active IP Right Cessation
- 1985-11-01 IE IE268485A patent/IE58587B1/en not_active IP Right Cessation
- 1985-11-02 CN CN85108133A patent/CN1013445B/zh not_active Expired
- 1985-11-04 GR GR852643A patent/GR852643B/el unknown
Also Published As
Publication number | Publication date |
---|---|
FI854267L (fi) | 1986-05-03 |
NO164541B (no) | 1990-07-09 |
KR930001410B1 (ko) | 1993-02-27 |
ZW19185A1 (en) | 1986-05-21 |
CN85108133A (zh) | 1986-04-10 |
EP0184322B1 (en) | 1989-12-20 |
EP0184322A1 (en) | 1986-06-11 |
GR852643B (ko) | 1986-03-05 |
NO854369L (no) | 1986-05-05 |
AU576634B2 (en) | 1988-09-01 |
PH22303A (en) | 1988-07-22 |
AR241592A1 (es) | 1992-09-30 |
JO1406B1 (en) | 1986-11-30 |
FI84718B (fi) | 1991-09-30 |
CN1013445B (zh) | 1991-08-07 |
PT81420A (en) | 1985-11-01 |
NO164541C (no) | 1990-10-17 |
ES8701752A1 (es) | 1986-12-01 |
IE852684L (en) | 1986-05-02 |
DK501085D0 (da) | 1985-10-31 |
ES548409A0 (es) | 1986-12-01 |
CA1253150A (en) | 1989-04-25 |
DE3574873D1 (en) | 1990-01-25 |
HUT39176A (en) | 1986-08-28 |
IE58587B1 (en) | 1993-10-06 |
FI854267A0 (fi) | 1985-10-30 |
FI84718C (fi) | 1992-01-10 |
HU200763B (en) | 1990-08-28 |
DK501085A (da) | 1986-05-03 |
PT81420B (pt) | 1988-05-27 |
AU4920785A (en) | 1986-05-08 |
NZ214024A (en) | 1989-08-29 |
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