PT2188289E - (7h-pirrolo[2,3-d]pirimidin-4-il)piperazinas como inibidores de quinases para o tratamento de cancro e de inflamação - Google Patents

(7h-pirrolo[2,3-d]pirimidin-4-il)piperazinas como inibidores de quinases para o tratamento de cancro e de inflamação Download PDF

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Publication number
PT2188289E
PT2188289E PT87826848T PT08782684T PT2188289E PT 2188289 E PT2188289 E PT 2188289E PT 87826848 T PT87826848 T PT 87826848T PT 08782684 T PT08782684 T PT 08782684T PT 2188289 E PT2188289 E PT 2188289E
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PT
Portugal
Prior art keywords
piperazines
pyrrolo
pyrimidin
inflammation
cancer
Prior art date
Application number
PT87826848T
Other languages
English (en)
Inventor
Spencer David Kimball
Bryce Alden Harrison
Ross Mabon
David Brent Rawlins
Dennis S Rice
Yulian Zhang
Original Assignee
Lexicon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc
Publication of PT2188289E publication Critical patent/PT2188289E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PT87826848T 2007-08-08 2008-08-08 (7h-pirrolo[2,3-d]pirimidin-4-il)piperazinas como inibidores de quinases para o tratamento de cancro e de inflamação PT2188289E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95469807P 2007-08-08 2007-08-08

Publications (1)

Publication Number Publication Date
PT2188289E true PT2188289E (pt) 2015-12-21

Family

ID=39873878

Family Applications (1)

Application Number Title Priority Date Filing Date
PT87826848T PT2188289E (pt) 2007-08-08 2008-08-08 (7h-pirrolo[2,3-d]pirimidin-4-il)piperazinas como inibidores de quinases para o tratamento de cancro e de inflamação

Country Status (12)

Country Link
US (1) US8507672B2 (pt)
EP (2) EP2597098A1 (pt)
JP (2) JP5406838B2 (pt)
CN (1) CN101772502A (pt)
AU (1) AU2008285388B2 (pt)
CA (1) CA2695857C (pt)
DK (1) DK2188289T3 (pt)
ES (1) ES2557931T3 (pt)
HU (1) HUE025788T2 (pt)
PL (1) PL2188289T3 (pt)
PT (1) PT2188289E (pt)
WO (1) WO2009021169A2 (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8193202B2 (en) * 2008-04-21 2012-06-05 Lexicon Pharmaceuticals, Inc. LIMK2 inhibitors, compositions comprising them, and methods of their use
EP2352501B1 (en) * 2008-11-03 2014-01-01 ChemoCentryx, Inc. Compounds for use in the treatment of osteoporosis
EP2451813B1 (en) * 2009-07-08 2014-10-01 Leo Pharma A/S Heterocyclic compounds as jak receptor and protein tyrosine kinase inhibitors
AU2011207280A1 (en) 2010-01-22 2012-07-19 Lexicon Pharmaceuticals, Inc. 5-(1h-pyrazol-5-yl)thiazole-based compounds for the treatment of diseases and disorders of the eye
TW201204732A (en) * 2010-07-09 2012-02-01 Leo Pharma As Novel homopiperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use thereof
CN102372717B (zh) * 2010-08-20 2014-06-18 和记黄埔医药（上海）有限公司 吡咯并嘧啶类化合物及其用途
RU2013136906A (ru) * 2011-01-07 2015-02-20 Лео Фарма А/С Новые производные сульфамидпиперазина в качестве ингибиторов протеинтирозинкиназы и их фармацевтическое применение
WO2013182612A1 (en) * 2012-06-07 2013-12-12 Bayer Pharma Aktiengesellschaft Glucose transport inhibitors
MX2014015648A (es) 2012-06-28 2015-08-05 Abbvie Inc Cianoguanidinas y usos de las mismas.
EP2867201A1 (en) * 2012-06-28 2015-05-06 Ramot at Tel-Aviv University Ltd. Lim kinase inhibitors
AU2013312477B2 (en) * 2012-09-06 2018-05-31 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
WO2014145576A2 (en) 2013-03-15 2014-09-18 Northwestern University Substituted pyrrolo(2,3-d)pyrimidines for the treatment of cancer
WO2015150337A1 (en) 2014-04-01 2015-10-08 Amakem Nv Lim kinase inhibitors
CN104876933A (zh) * 2015-05-12 2015-09-02 烟台万润药业有限公司 一种含氮杂环酰基哌嗪类化合物及其制备方法与应用
WO2017201187A1 (en) * 2016-05-18 2017-11-23 Virongy, Llc Lim kinase inhibitors
JP2019532944A (ja) * 2016-09-23 2019-11-14 セルイプセ Ｌｉｍｋ介在性疾患における、ｌｉｍキナーゼ阻害剤、医薬組成物および使用方法
CN111620854A (zh) * 2019-02-28 2020-09-04 上海医药工业研究院 4-氨基嘧啶取代的苯基酰胺类化合物及其制备方法
US20220288081A1 (en) * 2019-09-25 2022-09-15 Macquarie University Treatment of excitotoxicity-related conditions
US20220288082A1 (en) * 2019-09-25 2022-09-15 Macquarie University Treatment of dementia
EP3915990A1 (en) * 2020-05-26 2021-12-01 Centre National de la Recherche Scientifique 4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-3,6-dihydropyridine-1-(2h)-carboxamide derivatives as limk and/or rock kinases inhibitors for use in the treatment of cancer

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136173A (en) 1977-01-31 1979-01-23 American Home Products Corp. Mixed xanthan gum and locust beam gum therapeutic compositions
US5753664A (en) 1995-03-16 1998-05-19 Takeda Chemical Industries, Ltd. Heterocyclic compounds, their production and use
PA8474101A1 (es) 1998-06-19 2000-09-29 Pfizer Prod Inc Compuestos de pirrolo [2,3-d] pirimidina
DE60237917D1 (de) 2001-06-05 2010-11-18 Exelixis Inc Gfats als modifikatoren des p53-wegs und verwendungsverfahren
AU2003302377A1 (en) 2002-11-27 2004-06-18 Santen Pharmaceutical Co., Ltd. Remedy for glaucoma containing lim kinase inhibitory compound as active ingredient
TWI336257B (en) 2003-06-13 2011-01-21 Alcon Inc Ophthalmic compositions containing a synergistic combination of three polymers
EP1684694A2 (en) * 2003-11-21 2006-08-02 Array Biopharma, Inc. Akt protein kinase inhibitors
US20060178388A1 (en) 2005-02-04 2006-08-10 Wrobleski Stephen T Phenyl-substituted pyrimidine compounds useful as kinase inhibitors
WO2006091450A1 (en) * 2005-02-18 2006-08-31 Lexicon Genetics Incorporated 4-piperidin-1-yl-7h-pyrrolo[2,3-d]pyrimidine compounds
US20080076924A1 (en) * 2006-06-30 2008-03-27 Patrick Betschmann Piperazines as P2X7 antagonists
CA2682733A1 (en) * 2007-04-13 2008-10-23 Supergen, Inc. Axl kinase inhibitors

Also Published As

Publication number Publication date
EP2188289B1 (en) 2015-10-28
JP2014040432A (ja) 2014-03-06
AU2008285388B2 (en) 2013-09-19
HUE025788T2 (en) 2016-04-28
PL2188289T3 (pl) 2016-04-29
WO2009021169A2 (en) 2009-02-12
US20090042893A1 (en) 2009-02-12
JP5406838B2 (ja) 2014-02-05
CA2695857A1 (en) 2009-02-12
CN101772502A (zh) 2010-07-07
WO2009021169A3 (en) 2009-04-30
EP2188289A2 (en) 2010-05-26
EP2597098A1 (en) 2013-05-29
CA2695857C (en) 2015-08-04
ES2557931T3 (es) 2016-01-29
US8507672B2 (en) 2013-08-13
JP2010535813A (ja) 2010-11-25
DK2188289T3 (en) 2016-01-25
AU2008285388A1 (en) 2009-02-12

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