YU49206B - Makromolekularni sastavi koji se mogu dispergovati i postupci za njihovo dobijanje - Google Patents

Makromolekularni sastavi koji se mogu dispergovati i postupci za njihovo dobijanje

Info

Publication number
YU49206B
YU49206B YU50198A YU50198A YU49206B YU 49206 B YU49206 B YU 49206B YU 50198 A YU50198 A YU 50198A YU 50198 A YU50198 A YU 50198A YU 49206 B YU49206 B YU 49206B
Authority
YU
Yugoslavia
Prior art keywords
macromolecules
liquid medium
weight
flowing
under conditions
Prior art date
Application number
YU50198A
Other languages
English (en)
Other versions
YU50198A (sh
Inventor
M. Robert Platz
K. Thomas Brewer
D. Terence Boardman
Original Assignee
Nektar Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics
Publication of YU50198A publication Critical patent/YU50198A/sh
Publication of YU49206B publication Critical patent/YU49206B/sh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Glanulating (AREA)

Abstract

Postupak za izradu disperzibilnih suvih praškova bioloških makromolekula, naznačen time, što obuhvata: obezbeđivanje isparljivog tečnog medijuma, koji sadrži prethodno određenu koncentraciju makromolekula i podloga, gde je makromolekul protein sa molekulskom težinom iznad 2 kD i prisutan je u koncentraciji ispod 10% težine i gde je tečni medijum vodeni medijum, koji sadrži značajno vodu, makromolekul i podloge; proticanje tečnog medijuma i struje atomizacionog gasa pri odnosu masenog protoka gas:tečnost iznad 5, pod uslovima, odabranim da se obrazuju kapljice, koje imaju srednju veličinu ispod 11 Вµm; proticanje kapljica u zagrejanoj struji gasa pod uslovima, odabranim da se obrazuju disperzibilne čestice materijala smeše, koji sadrži biološke makrmolekule, navedene čestice sa sadržajem vlage ispod 10% težine i rugozitetom iznad 2, izmerenim vazdušnom permeametrijom; i sakupljanje čestica. Prijava sadrži još 19 zavisnih zahteva.
YU50198A 1996-05-08 1997-05-07 Makromolekularni sastavi koji se mogu dispergovati i postupci za njihovo dobijanje YU49206B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/644,681 US6051256A (en) 1994-03-07 1996-05-08 Dispersible macromolecule compositions and methods for their preparation and use

Publications (2)

Publication Number Publication Date
YU50198A YU50198A (sh) 2000-12-28
YU49206B true YU49206B (sh) 2004-09-03

Family

ID=24585923

Family Applications (1)

Application Number Title Priority Date Filing Date
YU50198A YU49206B (sh) 1996-05-08 1997-05-07 Makromolekularni sastavi koji se mogu dispergovati i postupci za njihovo dobijanje

Country Status (30)

Country Link
US (5) US6051256A (sh)
EP (1) EP0948317A4 (sh)
JP (2) JP2000510471A (sh)
CN (1) CN1138531C (sh)
AP (1) AP987A (sh)
AU (1) AU730059B2 (sh)
BG (1) BG64113B1 (sh)
BR (1) BR9709057A (sh)
CA (1) CA2253393C (sh)
CZ (1) CZ295644B6 (sh)
EA (1) EA000956B1 (sh)
EE (1) EE03591B1 (sh)
GE (1) GEP20012345B (sh)
HK (1) HK1020319A1 (sh)
IL (1) IL126754A (sh)
IS (1) IS4879A (sh)
LT (1) LT4553B (sh)
LV (1) LV12231B (sh)
NO (1) NO985196L (sh)
NZ (1) NZ332480A (sh)
OA (1) OA10914A (sh)
PL (1) PL190732B1 (sh)
RO (1) RO118523B1 (sh)
SI (1) SI9720031A (sh)
SK (1) SK285400B6 (sh)
TR (1) TR199802247T2 (sh)
TW (1) TW550089B (sh)
UA (1) UA65538C2 (sh)
WO (1) WO1997041833A1 (sh)
YU (1) YU49206B (sh)

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