DK0877602T3 - Fremgangsmåde til fremstilling af pulverformede lungesurfactant-præparater - Google Patents

Fremgangsmåde til fremstilling af pulverformede lungesurfactant-præparater

Info

Publication number
DK0877602T3
DK0877602T3 DK97902186T DK97902186T DK0877602T3 DK 0877602 T3 DK0877602 T3 DK 0877602T3 DK 97902186 T DK97902186 T DK 97902186T DK 97902186 T DK97902186 T DK 97902186T DK 0877602 T3 DK0877602 T3 DK 0877602T3
Authority
DK
Denmark
Prior art keywords
preparation
pulmonary surfactant
lung surfactant
surfactant preparations
powdered
Prior art date
Application number
DK97902186T
Other languages
English (en)
Inventor
Klaus Eistetter
Original Assignee
Byk Gulden Lomberg Chem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19602332A external-priority patent/DE19602332A1/de
Application filed by Byk Gulden Lomberg Chem Fab filed Critical Byk Gulden Lomberg Chem Fab
Application granted granted Critical
Publication of DK0877602T3 publication Critical patent/DK0877602T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0082—Lung surfactant, artificial mucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
DK97902186T 1996-01-24 1997-01-18 Fremgangsmåde til fremstilling af pulverformede lungesurfactant-præparater DK0877602T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19602332A DE19602332A1 (de) 1996-01-24 1996-01-24 Verfahren zur Herstellung von pulverförmigen Lungensurfactant-Zubereitungen
EP96103442 1996-03-06
PCT/EP1997/000230 WO1997026863A1 (de) 1996-01-24 1997-01-18 Verfahren zur herstellung von pulverförmigen lungensurfactant-zubereitungen

Publications (1)

Publication Number Publication Date
DK0877602T3 true DK0877602T3 (da) 2002-05-06

Family

ID=26022286

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97902186T DK0877602T3 (da) 1996-01-24 1997-01-18 Fremgangsmåde til fremstilling af pulverformede lungesurfactant-præparater

Country Status (15)

Country Link
US (1) US6315983B1 (da)
EP (1) EP0877602B1 (da)
JP (1) JP3725166B2 (da)
KR (1) KR100449789B1 (da)
AT (1) ATE212220T1 (da)
CA (1) CA2244767C (da)
CY (1) CY2366B1 (da)
CZ (1) CZ292186B6 (da)
DE (1) DE59706180D1 (da)
DK (1) DK0877602T3 (da)
ES (1) ES2171883T3 (da)
PT (1) PT877602E (da)
TR (1) TR199801408T2 (da)
UA (1) UA59358C2 (da)
WO (1) WO1997026863A1 (da)

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US20030203036A1 (en) * 2000-03-17 2003-10-30 Gordon Marc S. Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
US20060165606A1 (en) * 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6565885B1 (en) * 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
DK1107743T3 (da) * 1998-08-25 2007-10-22 Advanced Inhalation Res Inc Stabile, spraytörrede proteinformuleringer
EP1767195A3 (en) * 1998-08-25 2007-04-04 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
ES2253003T3 (es) * 1998-11-10 2006-05-16 Altana Pharma Ag Equipo de tratamiento que contiene composiciones a base de agentes tensioactivos pulmonares.
AU5400000A (en) * 1999-06-11 2001-01-02 Byk Gulden Lomberg Chemische Fabrik Gmbh Pharmaceutical preparation containing modifications of surfactant protein b (sp-b) and surfactant protein c (sp-c)
ATE285755T1 (de) * 1999-08-25 2005-01-15 Advanced Inhalation Res Inc Grosse poröse partikel erhältlich durch sprühtrocknung und geeignet zur pulmonalen anwendung
US6749835B1 (en) * 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
WO2001019392A1 (en) 1999-09-16 2001-03-22 Byk Gulden Lomberg Chemische Fabrik Gmbh Combination of c1-inh and lung surfactant for the treatment of respiratory disorders
DE19957898A1 (de) * 1999-12-01 2001-06-07 Byk Gulden Lomberg Chem Fab Neue Verwendung von Lungensurfactant
US7871598B1 (en) * 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
WO2001085136A2 (en) 2000-05-10 2001-11-15 Alliance Pharmaceutical Corporation Phospholipid-based powders for drug delivery
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
US7575761B2 (en) 2000-06-30 2009-08-18 Novartis Pharma Ag Spray drying process control of drying kinetics
ES2346048T3 (es) 2001-10-11 2010-10-08 Nycomed Gmbh Nueva utilizacion de un agente tensioactivo pulmonar.
WO2003043603A1 (en) * 2001-11-20 2003-05-30 Advanced Inhalation Research, Inc. Particulate compositions for improving solubility of poorly soluble agents
JP2005514393A (ja) 2001-12-19 2005-05-19 ネクター セラピューティクス アミノグリコシドの肺への供給
US20030170223A1 (en) * 2002-02-01 2003-09-11 Board Of Trustees Of Michigan State University Pulmonary vasodilator surfactant compositions and method of use
JPWO2003077891A1 (ja) * 2002-03-18 2005-07-14 アステラス製薬株式会社 吸入用粉末医薬組成物およびその製造方法
US20040184995A1 (en) * 2003-03-17 2004-09-23 Yamanouchi Pharmaceutical Co., Ltd. Novel dry powder inhalation for lung-delivery and manufacturing method thereof
US20060078506A1 (en) * 2004-05-20 2006-04-13 Ralph Niven Methods, systems and devices for noninvasive pulmonary delivery
ATE457736T1 (de) * 2004-08-06 2010-03-15 Nycomed Gmbh Zusammensetzung aus einem pulmonalen surfactant und einem von tnf stammenden peptid
US8337815B2 (en) 2004-12-23 2012-12-25 Discovery Laboratories, Inc. Pulmonary surfactant formulations
CN101094651B (zh) * 2004-12-30 2011-03-09 多贝尔有限公司 含有胶原凝集素家族蛋白质或者其变体的喷雾干燥的组合物和其制备方法
US8028697B2 (en) 2005-04-28 2011-10-04 Trudell Medical International Ventilator circuit and method for the use thereof
EP2009023A1 (en) * 2007-06-04 2008-12-31 Rentschler Beteiligungs GmbH Novel peptides and their use for the treatment of edema
PL2265309T3 (pl) * 2008-03-17 2016-06-30 Discovery Lab Inc Adapter obwodu oddechowego i proksymalny system podawania aerozolu
ES2402241T3 (es) 2008-10-22 2013-04-30 Trudell Medical International Sistema de suministro de aerosol modular
AU2009324637B2 (en) 2008-12-10 2016-09-08 Paka Pulmonary Pharmaceuticals, Inc. Methods and compositions for delivery of medicaments to the lungs
EP2410981B2 (en) * 2009-03-26 2020-02-26 Pulmatrix Operating Company, Inc. Dry powder formulations and methods for treating pulmonary diseases
DK2308489T3 (da) * 2009-10-05 2014-03-24 Nutri Fit Gmbh & Co Kg Sammensætninger til anvendelse ved behandling eller forebyggelse af lungeskade, der fremkaldes af en stofskiftebelastning samt fremgangsmåder til forøgelse af pattedyrs fysiske kapacitet
NZ607358A (en) 2010-08-23 2015-04-24 Takeda Gmbh Humidified particles comprising a therapeutically active substance
WO2013149013A1 (en) 2012-03-28 2013-10-03 Discovery Laboratories, Inc. Lyophilization of synthetic liposomal pulmonary surfactant
BR112016020393B1 (pt) 2014-03-05 2022-03-29 Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Umidificador para umidificar um aerossol
WO2015132174A1 (en) 2014-03-05 2015-09-11 Takeda Gmbh Device for providing a constant amount of aerosol
AU2015233635B2 (en) * 2014-03-18 2019-07-25 Apeptico Forschung Und Entwicklung Gmbh Dry-powder peptide medicament
CA3028724A1 (en) * 2016-06-24 2017-12-28 Civitas Therapeutics, Inc. Surfactant formulations for inhalation
AU2018392458A1 (en) * 2017-12-21 2020-07-02 Civitas Therapeutics, Inc. Surfactant formulations for inhalation
MX2020006634A (es) 2017-12-21 2021-01-15 Civitas Therapeutics Inc Formulaciones de surfactantes para inhalacion.

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JPS58183621A (ja) * 1982-04-22 1983-10-26 Teijin Ltd 肺表面活性物質を有効成分とする粉末剤の調製法
DE3229179C2 (de) 1982-08-05 1986-04-17 A. Nattermann & Cie GmbH, 5000 Köln Lungensurfactant
JPS59164724A (ja) * 1983-03-10 1984-09-17 Tokyo Tanabe Co Ltd サ−フアクタント及びそれを含有する呼吸窮迫症候群治療剤
US5164369A (en) 1988-01-06 1992-11-17 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US5260273A (en) 1988-01-06 1993-11-09 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
ATE201880T1 (de) 1989-07-11 2001-06-15 Genentech Inc Oberflächenaktive zusammensetzungen und verfahren
IN172208B (da) * 1990-04-02 1993-05-01 Sint Sa
WO1992006703A1 (en) 1990-10-17 1992-04-30 The Liposome Company, Inc. Synthetic lung surfactant
US6582728B1 (en) * 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
EP0655237A1 (de) * 1993-11-27 1995-05-31 Hoechst Aktiengesellschaft Medizinische Aerosolformulierung
US6051256A (en) * 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
AU689217B2 (en) 1994-03-07 1998-03-26 Novartis Ag Methods and compositions for pulmonary delivery of insulin
US6136346A (en) * 1995-04-14 2000-10-24 Inhale Therapeutic Systems Powdered pharmaceutical formulations having improved dispersibility
US6019968A (en) 1995-04-14 2000-02-01 Inhale Therapeutic Systems, Inc. Dispersible antibody compositions and methods for their preparation and use
US5780014A (en) 1995-04-14 1998-07-14 Inhale Therapeutic Systems Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin
WO1998029098A1 (en) * 1996-12-31 1998-07-09 Inhale Therapeutic Systems, Inc. Processes for spray drying aqueous suspensions of hydrophobic drugs with hydrophilic excipients and compositions prepared by such processes
GB9814172D0 (en) 1998-06-30 1998-08-26 Andaris Ltd Formulation for inhalation
DK1107743T3 (da) 1998-08-25 2007-10-22 Advanced Inhalation Res Inc Stabile, spraytörrede proteinformuleringer

Also Published As

Publication number Publication date
CA2244767C (en) 2005-11-22
EP0877602A1 (de) 1998-11-18
ATE212220T1 (de) 2002-02-15
PT877602E (pt) 2002-07-31
WO1997026863A1 (de) 1997-07-31
TR199801408T2 (xx) 1998-10-21
CZ233898A3 (cs) 1999-02-17
JP2000503976A (ja) 2000-04-04
ES2171883T3 (es) 2002-09-16
UA59358C2 (uk) 2003-09-15
CA2244767A1 (en) 1997-07-31
CZ292186B6 (cs) 2003-08-13
US6315983B1 (en) 2001-11-13
KR19990081886A (ko) 1999-11-15
DE59706180D1 (de) 2002-03-14
JP3725166B2 (ja) 2005-12-07
KR100449789B1 (ko) 2005-02-03
CY2366B1 (en) 2004-06-04
EP0877602B1 (de) 2002-01-23

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