CY2366B1 - Process for the production of powdered pulmonary surfactant preparations. - Google Patents

Process for the production of powdered pulmonary surfactant preparations.

Info

Publication number
CY2366B1
CY2366B1 CY0300048A CY0300048A CY2366B1 CY 2366 B1 CY2366 B1 CY 2366B1 CY 0300048 A CY0300048 A CY 0300048A CY 0300048 A CY0300048 A CY 0300048A CY 2366 B1 CY2366 B1 CY 2366B1
Authority
CY
Cyprus
Prior art keywords
pulmonary surfactant
production
powdered
surfactant preparations
powdered pulmonary
Prior art date
Application number
CY0300048A
Other languages
English (en)
Inventor
Klaus Eistetter
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19602332A external-priority patent/DE19602332A1/de
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of CY2366B1 publication Critical patent/CY2366B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0082—Lung surfactant, artificial mucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Zoology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CY0300048A 1996-01-24 2003-06-24 Process for the production of powdered pulmonary surfactant preparations. CY2366B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19602332A DE19602332A1 (de) 1996-01-24 1996-01-24 Verfahren zur Herstellung von pulverförmigen Lungensurfactant-Zubereitungen
EP96103442 1996-03-06

Publications (1)

Publication Number Publication Date
CY2366B1 true CY2366B1 (en) 2004-06-04

Family

ID=26022286

Family Applications (1)

Application Number Title Priority Date Filing Date
CY0300048A CY2366B1 (en) 1996-01-24 2003-06-24 Process for the production of powdered pulmonary surfactant preparations.

Country Status (15)

Country Link
US (1) US6315983B1 (xx)
EP (1) EP0877602B1 (xx)
JP (1) JP3725166B2 (xx)
KR (1) KR100449789B1 (xx)
AT (1) ATE212220T1 (xx)
CA (1) CA2244767C (xx)
CY (1) CY2366B1 (xx)
CZ (1) CZ292186B6 (xx)
DE (1) DE59706180D1 (xx)
DK (1) DK0877602T3 (xx)
ES (1) ES2171883T3 (xx)
PT (1) PT877602E (xx)
TR (1) TR199801408T2 (xx)
UA (1) UA59358C2 (xx)
WO (1) WO1997026863A1 (xx)

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US20030203036A1 (en) 2000-03-17 2003-10-30 Gordon Marc S. Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
US20060165606A1 (en) * 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6565885B1 (en) * 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
ATE365547T1 (de) * 1998-08-25 2007-07-15 Advanced Inhalation Res Inc Sprühgetrocknete proteinformulierungen
EP1767195A3 (en) * 1998-08-25 2007-04-04 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
ATE308976T1 (de) * 1998-11-10 2005-11-15 Altana Pharma Ag Lungensurfactant zubereitungen enthaltendes behandlungset
WO2000076535A1 (en) * 1999-06-11 2000-12-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Pharmaceutical preparation containing modifications of surfactant protein b (sp-b) and surfactant protein c (sp-c)
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
US6749835B1 (en) * 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
DE60017152D1 (de) * 1999-08-25 2005-02-03 Advanced Inhalation Res Inc Grosse poröse partikel erhältlich durch sprühtrocknung und geeignet zur pulmonalen anwendung
AU6083899A (en) 1999-09-16 2001-04-17 Aventis Behring Gmbh Combination of c1-inh and lung surfactant for the treatment of respiratory disorders
DE19957898A1 (de) * 1999-12-01 2001-06-07 Byk Gulden Lomberg Chem Fab Neue Verwendung von Lungensurfactant
US7442388B2 (en) 2000-05-10 2008-10-28 Weers Jeffry G Phospholipid-based powders for drug delivery
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
US7871598B1 (en) * 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US7575761B2 (en) 2000-06-30 2009-08-18 Novartis Pharma Ag Spray drying process control of drying kinetics
JP4559731B2 (ja) 2001-10-11 2010-10-13 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 肺サーファクタントの新規使用
WO2003043603A1 (en) * 2001-11-20 2003-05-30 Advanced Inhalation Research, Inc. Particulate compositions for improving solubility of poorly soluble agents
SI1458360T1 (sl) 2001-12-19 2011-08-31 Novartis Ag Pulmonalno dajanje aminoglikozidov
US20030170223A1 (en) * 2002-02-01 2003-09-11 Board Of Trustees Of Michigan State University Pulmonary vasodilator surfactant compositions and method of use
WO2003077891A1 (fr) * 2002-03-18 2003-09-25 Yamanouchi Pharmaceutical Co., Ltd. Compositions medicales en poudre pour inhalation et procede de production de celles-ci
US20040184995A1 (en) * 2003-03-17 2004-09-23 Yamanouchi Pharmaceutical Co., Ltd. Novel dry powder inhalation for lung-delivery and manufacturing method thereof
EP1755720A1 (en) * 2004-05-20 2007-02-28 Discovery Laboratories, Inc. Methods , systems and devices for noninvasive pulmonary delivery
US8236750B2 (en) * 2004-08-06 2012-08-07 Nycomed Gmbh Composition comprising a pulmonary surfactant and a TNF-derived peptide
US8337815B2 (en) 2004-12-23 2012-12-25 Discovery Laboratories, Inc. Pulmonary surfactant formulations
EP1830810A4 (en) * 2004-12-30 2011-02-02 Dobeel Co Ltd SPRAY-DRYED COMPOSITION WITH PROTEINS OF THE COLLECTIN FAMILY OR VARIATIONS THEREOF AND METHOD OF PREPARATION THEREOF
US8028697B2 (en) 2005-04-28 2011-10-04 Trudell Medical International Ventilator circuit and method for the use thereof
EP2009023A1 (en) * 2007-06-04 2008-12-31 Rentschler Beteiligungs GmbH Novel peptides and their use for the treatment of edema
EP2265309B1 (en) 2008-03-17 2015-12-16 Discovery Laboratories, Inc. Ventilation circuit adaptor and proximal aerosol delivery system
CA2683353C (en) 2008-10-22 2015-12-15 Trudell Medical International Modular aerosol delivery system
CA2744940A1 (en) 2008-12-10 2010-06-17 Paka Pulmonary Pharmaceuticals, Inc. Methods and compositions for delivery of medicaments to the lungs
ES2625260T5 (es) * 2009-03-26 2020-07-29 Pulmatrix Operating Co Inc Formulaciones de polvo seco y métodos para el tratamiento de enfermedades pulmonares
EP2711004A1 (en) * 2009-10-05 2014-03-26 Nutri-Fit GmbH & Co. KG Methods for increasing physical capacity of mammalian livestock
EP2608769B1 (en) 2010-08-23 2019-11-06 Fraunhofer Gesellschaft zur Förderung der Angewand Humidified particles comprising a therapeutically active substance
PT2723323E (pt) 2012-03-28 2016-01-27 Discovery Lab Inc Liofilização de tensioativo lipossómico sintético
KR102369135B1 (ko) 2014-03-05 2022-02-28 프라운호퍼-게젤샤프트 추르 푀르데룽 데어 안제반텐 포르슝 에 파우 에어로졸을 가습하기 위한 가습기
EP3113816B8 (en) 2014-03-05 2020-04-08 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Device for providing a constant amount of aerosol and control system
US10925924B2 (en) * 2014-03-18 2021-02-23 Apeptico Forschung Und Entwicklung Gmbh Dry-powder peptide medicament
MA45451A (fr) * 2016-06-24 2019-05-01 Civitas Therapeutics Inc Formulations tensioactives destinées à l'inhalation
JP7419253B2 (ja) * 2017-12-21 2024-01-22 キウィタス セラピューティクス，インコーポレイテッド 吸入のための界面活性剤製剤
JP7335263B2 (ja) * 2017-12-21 2023-08-29 キウィタス セラピューティクス，インコーポレイテッド 吸入のための界面活性剤製剤

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JPS58183621A (ja) * 1982-04-22 1983-10-26 Teijin Ltd 肺表面活性物質を有効成分とする粉末剤の調製法
DE3229179C2 (de) 1982-08-05 1986-04-17 A. Nattermann & Cie GmbH, 5000 Köln Lungensurfactant
JPS59164724A (ja) 1983-03-10 1984-09-17 Tokyo Tanabe Co Ltd サ−フアクタント及びそれを含有する呼吸窮迫症候群治療剤
US5164369A (en) 1988-01-06 1992-11-17 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US5260273A (en) 1988-01-06 1993-11-09 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
DK0482097T3 (da) 1989-07-11 2001-09-17 Genentech Inc Tensidpræparater og fremgangsmåder
IN172208B (xx) * 1990-04-02 1993-05-01 Sint Sa
JP3171445B2 (ja) 1990-10-17 2001-05-28 ザ リポソーム カンパニー，インコーポレイテッド 合成肺表面活性剤
US6582728B1 (en) * 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
EP0655237A1 (de) * 1993-11-27 1995-05-31 Hoechst Aktiengesellschaft Medizinische Aerosolformulierung
US6051256A (en) * 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
CZ295827B6 (cs) 1994-03-07 2005-11-16 Nektar Therapeutics Způsob aerosolizace dávky inzulinu, inzulinový přípravek a jeho použití
US5780014A (en) 1995-04-14 1998-07-14 Inhale Therapeutic Systems Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin
WO1996032096A1 (en) * 1995-04-14 1996-10-17 Inhale Therapeutic Systems Powdered pharmaceutical formulations having improved dispersibility
US6019968A (en) 1995-04-14 2000-02-01 Inhale Therapeutic Systems, Inc. Dispersible antibody compositions and methods for their preparation and use
AU6014098A (en) * 1996-12-31 1998-07-31 Inhale Therapeutic Systems Aerosolized hydrophobic drug
GB9814172D0 (en) 1998-06-30 1998-08-26 Andaris Ltd Formulation for inhalation
ATE365547T1 (de) 1998-08-25 2007-07-15 Advanced Inhalation Res Inc Sprühgetrocknete proteinformulierungen

Also Published As

Publication number Publication date
WO1997026863A1 (de) 1997-07-31
UA59358C2 (uk) 2003-09-15
JP3725166B2 (ja) 2005-12-07
US6315983B1 (en) 2001-11-13
CA2244767A1 (en) 1997-07-31
CZ292186B6 (cs) 2003-08-13
KR100449789B1 (ko) 2005-02-03
CZ233898A3 (cs) 1999-02-17
ES2171883T3 (es) 2002-09-16
DE59706180D1 (de) 2002-03-14
EP0877602B1 (de) 2002-01-23
CA2244767C (en) 2005-11-22
ATE212220T1 (de) 2002-02-15
TR199801408T2 (xx) 1998-10-21
DK0877602T3 (da) 2002-05-06
KR19990081886A (ko) 1999-11-15
EP0877602A1 (de) 1998-11-18
JP2000503976A (ja) 2000-04-04
PT877602E (pt) 2002-07-31

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