PT877602E - Processo para o fabrico de composicoes de surfactantes pulmonares em po - Google Patents

Processo para o fabrico de composicoes de surfactantes pulmonares em po

Info

Publication number
PT877602E
PT877602E PT97902186T PT97902186T PT877602E PT 877602 E PT877602 E PT 877602E PT 97902186 T PT97902186 T PT 97902186T PT 97902186 T PT97902186 T PT 97902186T PT 877602 E PT877602 E PT 877602E
Authority
PT
Portugal
Prior art keywords
pulmonary surfactant
manufacture
surfactant compositions
hydrophobic protein
protein serving
Prior art date
Application number
PT97902186T
Other languages
English (en)
Inventor
Klaus Eistetter
Original Assignee
Byk Gulden Lomberg Chem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19602332A external-priority patent/DE19602332A1/de
Application filed by Byk Gulden Lomberg Chem Fab filed Critical Byk Gulden Lomberg Chem Fab
Publication of PT877602E publication Critical patent/PT877602E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0082—Lung surfactant, artificial mucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
PT97902186T 1996-01-24 1997-01-18 Processo para o fabrico de composicoes de surfactantes pulmonares em po PT877602E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19602332A DE19602332A1 (de) 1996-01-24 1996-01-24 Verfahren zur Herstellung von pulverförmigen Lungensurfactant-Zubereitungen
EP96103442 1996-03-06

Publications (1)

Publication Number Publication Date
PT877602E true PT877602E (pt) 2002-07-31

Family

ID=26022286

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97902186T PT877602E (pt) 1996-01-24 1997-01-18 Processo para o fabrico de composicoes de surfactantes pulmonares em po

Country Status (15)

Country Link
US (1) US6315983B1 (pt)
EP (1) EP0877602B1 (pt)
JP (1) JP3725166B2 (pt)
KR (1) KR100449789B1 (pt)
AT (1) ATE212220T1 (pt)
CA (1) CA2244767C (pt)
CY (1) CY2366B1 (pt)
CZ (1) CZ292186B6 (pt)
DE (1) DE59706180D1 (pt)
DK (1) DK0877602T3 (pt)
ES (1) ES2171883T3 (pt)
PT (1) PT877602E (pt)
TR (1) TR199801408T2 (pt)
UA (1) UA59358C2 (pt)
WO (1) WO1997026863A1 (pt)

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US20030203036A1 (en) 2000-03-17 2003-10-30 Gordon Marc S. Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
US20060165606A1 (en) * 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6565885B1 (en) * 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
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EP1767195A3 (en) * 1998-08-25 2007-04-04 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
WO2000027360A1 (en) * 1998-11-10 2000-05-18 Byk Gulden Lomberg Chemische Fabrik Gmbh Treatment set containing lungsurfactant compositions
CA2372558A1 (en) * 1999-06-11 2000-12-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Pharmaceutical preparation containing modifications of surfactant protein b (sp-b) and surfactant protein c (sp-c)
US6749835B1 (en) 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
DE60017152D1 (de) * 1999-08-25 2005-02-03 Advanced Inhalation Res Inc Grosse poröse partikel erhältlich durch sprühtrocknung und geeignet zur pulmonalen anwendung
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
CA2384861A1 (en) 1999-09-16 2001-03-22 Byk Gulden Lomberg Chemische Fabrik Gmbh Combination of c1-inh and lung surfactant for the treatment of respiratory disorders
DE19957898A1 (de) * 1999-12-01 2001-06-07 Byk Gulden Lomberg Chem Fab Neue Verwendung von Lungensurfactant
AU6124601A (en) † 2000-05-10 2001-11-20 Alliance Pharmaceutical Corporation Phospholipid-based powders for drug delivery
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US7575761B2 (en) 2000-06-30 2009-08-18 Novartis Pharma Ag Spray drying process control of drying kinetics
DE50214446D1 (de) 2001-10-11 2010-07-01 Nycomed Gmbh Neue verwendung von lungensurfactant
US20030129250A1 (en) * 2001-11-20 2003-07-10 Advanced Inhalation Research Inc. Particulate compositions for improving solubility of poorly soluble agents
JP2005514393A (ja) 2001-12-19 2005-05-19 ネクター セラピューティクス アミノグリコシドの肺への供給
US20030170223A1 (en) * 2002-02-01 2003-09-11 Board Of Trustees Of Michigan State University Pulmonary vasodilator surfactant compositions and method of use
WO2003077891A1 (fr) * 2002-03-18 2003-09-25 Yamanouchi Pharmaceutical Co., Ltd. Compositions medicales en poudre pour inhalation et procede de production de celles-ci
US20040184995A1 (en) * 2003-03-17 2004-09-23 Yamanouchi Pharmaceutical Co., Ltd. Novel dry powder inhalation for lung-delivery and manufacturing method thereof
JP2007537833A (ja) * 2004-05-20 2007-12-27 ディスカバリー ラボラトリーズ，インコーポレイテッド 非侵襲的な肺吸入のための方法、システム、及び装置
WO2006013183A1 (en) * 2004-08-06 2006-02-09 Altana Pharma Ag Composition comprising a pulmonary surfactant and a tnf-derived peptide
US8337815B2 (en) 2004-12-23 2012-12-25 Discovery Laboratories, Inc. Pulmonary surfactant formulations
KR100770362B1 (ko) * 2004-12-30 2007-10-26 (주)두비엘 분무건조 고분자형 콜렉틴족 단백질 및 그의 제조방법
US8028697B2 (en) 2005-04-28 2011-10-04 Trudell Medical International Ventilator circuit and method for the use thereof
EP2009023A1 (en) * 2007-06-04 2008-12-31 Rentschler Beteiligungs GmbH Novel peptides and their use for the treatment of edema
HUE028653T2 (en) 2008-03-17 2016-12-28 Discovery Lab Inc Respiratory circuit adapter and direct aerosol delivery system
EP2626098B1 (en) 2008-10-22 2020-08-19 Trudell Medical International Modular aerosol delivery system
CN102271666A (zh) 2008-12-10 2011-12-07 Paka肺部医药公司 用于向肺脏递送药物的方法和组合物
JP5671001B2 (ja) * 2009-03-26 2015-02-18 パルマトリックス，インコーポレイテッド 肺疾患を治療するための乾燥粉末製剤および方法
EP2711004A1 (en) 2009-10-05 2014-03-26 Nutri-Fit GmbH & Co. KG Methods for increasing physical capacity of mammalian livestock
AU2011295165B2 (en) 2010-08-23 2015-07-02 Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. Humidified particles comprising a therapeutically active substance
SI2723323T1 (sl) 2012-03-28 2016-04-29 Discovery Laboratories, Inc. Liofilizacija sintetičnega liposomskega pulmonalnega surfaktanta
BR112016020393B1 (pt) 2014-03-05 2022-03-29 Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Umidificador para umidificar um aerossol
KR102399923B1 (ko) 2014-03-05 2022-05-18 프라운호퍼-게젤샤프트 추르 푀르데룽 데어 안제반텐 포르슝 에 파우 일정한 양의 에어로졸을 제공하기 위한 디바이스
AU2015233635B2 (en) * 2014-03-18 2019-07-25 Apeptico Forschung Und Entwicklung Gmbh Dry-powder peptide medicament
MX2018015969A (es) * 2016-06-24 2019-06-10 Civitas Therapeutics Inc Formulaciones tensoactivas para inhalacion.
WO2019126289A1 (en) 2017-12-21 2019-06-27 Civitas Therapeutics, Inc. Surfactant formulations for inhalation
AU2018392458A1 (en) * 2017-12-21 2020-07-02 Civitas Therapeutics, Inc. Surfactant formulations for inhalation

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JPS58183621A (ja) * 1982-04-22 1983-10-26 Teijin Ltd 肺表面活性物質を有効成分とする粉末剤の調製法
DE3229179C2 (de) 1982-08-05 1986-04-17 A. Nattermann & Cie GmbH, 5000 Köln Lungensurfactant
JPS59164724A (ja) 1983-03-10 1984-09-17 Tokyo Tanabe Co Ltd サ−フアクタント及びそれを含有する呼吸窮迫症候群治療剤
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US5260273A (en) 1988-01-06 1993-11-09 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
AU638474B2 (en) 1989-07-11 1993-07-01 Genentech Inc. Surfactant compositions and methods
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ATE192930T1 (de) 1990-10-17 2000-06-15 Liposome Co Inc Synthetische oberflächenaktive agentien auf der lunge
US6582728B1 (en) * 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
EP0655237A1 (de) * 1993-11-27 1995-05-31 Hoechst Aktiengesellschaft Medizinische Aerosolformulierung
MX9603936A (es) 1994-03-07 1997-05-31 Inhale Therapeutic Syst Metodos y composiciones para el suministro pulmonar de insulina.
US6051256A (en) * 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
WO1996032096A1 (en) * 1995-04-14 1996-10-17 Inhale Therapeutic Systems Powdered pharmaceutical formulations having improved dispersibility
US6019968A (en) 1995-04-14 2000-02-01 Inhale Therapeutic Systems, Inc. Dispersible antibody compositions and methods for their preparation and use
US5780014A (en) * 1995-04-14 1998-07-14 Inhale Therapeutic Systems Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin
JP2001507702A (ja) * 1996-12-31 2001-06-12 インヘイル・セラピューティックス・システムズ・インコーポレテッド 親水性賦形剤を有する疎水性薬剤の水性懸濁液を噴霧乾燥させる方法およびその方法によって作製された組成物
GB9814172D0 (en) 1998-06-30 1998-08-26 Andaris Ltd Formulation for inhalation
EP1107743B1 (en) 1998-08-25 2007-06-27 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations

Also Published As

Publication number Publication date
ES2171883T3 (es) 2002-09-16
US6315983B1 (en) 2001-11-13
EP0877602B1 (de) 2002-01-23
WO1997026863A1 (de) 1997-07-31
UA59358C2 (uk) 2003-09-15
KR100449789B1 (ko) 2005-02-03
JP2000503976A (ja) 2000-04-04
ATE212220T1 (de) 2002-02-15
CA2244767C (en) 2005-11-22
DK0877602T3 (da) 2002-05-06
JP3725166B2 (ja) 2005-12-07
DE59706180D1 (de) 2002-03-14
TR199801408T2 (xx) 1998-10-21
KR19990081886A (ko) 1999-11-15
CY2366B1 (en) 2004-06-04
EP0877602A1 (de) 1998-11-18
CZ233898A3 (cs) 1999-02-17
CA2244767A1 (en) 1997-07-31
CZ292186B6 (cs) 2003-08-13

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