ATE137403T1 - Zubereitung von liposomen- und lipid- komplexzusammensetzungen - Google Patents

Zubereitung von liposomen- und lipid- komplexzusammensetzungen

Info

Publication number
ATE137403T1
ATE137403T1 AT90906530T AT90906530T ATE137403T1 AT E137403 T1 ATE137403 T1 AT E137403T1 AT 90906530 T AT90906530 T AT 90906530T AT 90906530 T AT90906530 T AT 90906530T AT E137403 T1 ATE137403 T1 AT E137403T1
Authority
AT
Austria
Prior art keywords
liposome
compounds
aprotic solvent
preparation
lipid complex
Prior art date
Application number
AT90906530T
Other languages
English (en)
Inventor
Francis C Szoka Jr
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of ATE137403T1 publication Critical patent/ATE137403T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A61K47/544—Phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
AT90906530T 1989-03-31 1990-03-28 Zubereitung von liposomen- und lipid- komplexzusammensetzungen ATE137403T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33260989A 1989-03-31 1989-03-31
US33405589A 1989-04-05 1989-04-05

Publications (1)

Publication Number Publication Date
ATE137403T1 true ATE137403T1 (de) 1996-05-15

Family

ID=26988293

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90906530T ATE137403T1 (de) 1989-03-31 1990-03-28 Zubereitung von liposomen- und lipid- komplexzusammensetzungen

Country Status (12)

Country Link
EP (1) EP0467954B1 (de)
JP (1) JP2798302B2 (de)
AT (1) ATE137403T1 (de)
AU (1) AU638245B2 (de)
CA (1) CA2050679C (de)
DE (1) DE69026820T2 (de)
DK (1) DK0467954T3 (de)
ES (1) ES2087151T3 (de)
HK (1) HK1000912A1 (de)
HU (1) HU208070B (de)
NO (1) NO303205B1 (de)
WO (1) WO1990011780A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5178875A (en) * 1991-01-14 1993-01-12 The Board Of Regents, The University Of Texas System Liposomal-polyene preliposomal powder and method for its preparation
JPH0363298A (ja) * 1989-07-31 1991-03-19 Green Cross Corp:The コロニー形成刺激因子・脂質複合体
FR2653015B1 (fr) * 1989-10-12 1993-10-29 Oreal Composition cosmetique ou pharmaceutique pour application topique contenant au moins un derive retinouide et au moins un derive de pyrimidine, son utilisation comme medicament et procede de traitement correspondant.
DE4238779A1 (de) * 1992-11-12 1994-05-19 Max Delbrueck Centrum Lyotrophe Mesophasen und ihre Anwendung in der Pharmazie, der Kosmetik und der Dermatologie
DK0707472T3 (da) 1993-07-08 2001-04-17 Liposome Co Inc Fremgangsmåde til regulering af størrelsen af liposomer
BR9405613A (pt) * 1993-09-29 1999-05-25 Gist Brocades Nv Uma nova composição antifúngica
AU705549B2 (en) * 1995-06-07 1999-05-27 Promega Biosciences, Inc. Phosphonic acid-based cationic lipids
JP2002532535A (ja) * 1998-12-22 2002-10-02 アメリカ合衆国 水不溶性薬剤送達システム
US6511676B1 (en) * 1999-11-05 2003-01-28 Teni Boulikas Therapy for human cancers using cisplatin and other drugs or genes encapsulated into liposomes
AU2001292287A1 (en) * 2000-10-26 2002-05-06 Senju Pharmaceutical Co. Ltd. Drug composition comprising dipeptydyl aldehyde derivative
JP2004522717A (ja) * 2000-12-01 2004-07-29 バイオミラ，インコーポレイテッド Ｐｅｇへの注入による大型リポソームの作製
IS6389A (is) * 2001-08-31 2003-03-03 Heraeus Kulzer Gmbh & Co. Kg Reynsla af sýklalyfjahúðun skrokka, sem í eru örholrými, og einnig af þannig húðuðum skrokkum og notkun þeirra
EP2146692A1 (de) * 2007-03-19 2010-01-27 Fresenius Kabi Oncology Limited Proliposomale und liposomale zusammensetzungen
CN101909581B (zh) * 2007-11-14 2012-11-14 加利福尼亚大学董事会 固醇修饰的两亲脂质
LT2344198T (lt) 2008-09-27 2021-02-25 Jina Pharmaceuticals Inc. Farmaciniai preparatai lipidų pagrindu, skirti vietiniam naudojimui
WO2012006956A1 (zh) * 2010-07-14 2012-01-19 中国医学科学院药物研究所 一种胰岛素的脂质复合物及其制备方法和制剂
EP3177269A4 (de) * 2014-08-04 2018-02-28 Zoneone Pharma, Inc. Fernladung von schwach wasserlöslichen medikamenten in lipidvesikel
CN113616798A (zh) * 2021-09-06 2021-11-09 天津农学院 一种甲苯咪唑脂质复合物、制备方法和应用
CN115177590A (zh) * 2022-04-20 2022-10-14 南昌大学抚州医学院 一种甲苯达唑类脂质体的制备方法及应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4588578A (en) * 1983-08-08 1986-05-13 The Liposome Company, Inc. Lipid vesicles prepared in a monophase
JPS60240634A (ja) 1984-05-08 1985-11-29 関　則雄 飲み干し容易なコツプ
US4619913A (en) * 1984-05-29 1986-10-28 Matrix Pharmaceuticals, Inc. Treatments employing drug-containing matrices for introduction into cellular lesion areas
AU598002B2 (en) * 1986-07-15 1990-06-14 Cilag Ltd. Method of preparing single bilayered liposomes
US4804539A (en) 1986-07-28 1989-02-14 Liposome Technology, Inc. Ophthalmic liposomes
US4839175A (en) * 1986-07-28 1989-06-13 Liposome Technology, Inc. Liposomes with enhanced retention on mucosal tissue
US4812312A (en) * 1987-03-03 1989-03-14 Board Of Regents Of The University Of Texas System Liposome-incorporated nystatin
NZ223660A (en) * 1987-03-05 1990-11-27 Liposome Co Inc Low toxicity drug-lipid complexes; methods of making them; and method of determining their toxicity

Also Published As

Publication number Publication date
EP0467954B1 (de) 1996-05-01
WO1990011780A1 (en) 1990-10-18
CA2050679A1 (en) 1990-10-01
EP0467954A4 (en) 1992-06-03
HUT59818A (en) 1992-07-28
DE69026820T2 (de) 1996-11-28
JPH04506207A (ja) 1992-10-29
NO303205B1 (no) 1998-06-15
JP2798302B2 (ja) 1998-09-17
NO913816L (no) 1991-11-26
ES2087151T3 (es) 1996-07-16
HU208070B (en) 1993-08-30
DK0467954T3 (da) 1996-05-28
HU903559D0 (en) 1991-12-30
EP0467954A1 (de) 1992-01-29
HK1000912A1 (en) 1998-05-08
DE69026820D1 (de) 1996-06-05
CA2050679C (en) 1998-09-22
AU638245B2 (en) 1993-06-24
AU5434590A (en) 1990-11-05
NO913816D0 (no) 1991-09-27

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee