ES2087151T3 - Preparacion de composiciones complejas de liposomas y lipidos. - Google Patents
Preparacion de composiciones complejas de liposomas y lipidos.Info
- Publication number
- ES2087151T3 ES2087151T3 ES90906530T ES90906530T ES2087151T3 ES 2087151 T3 ES2087151 T3 ES 2087151T3 ES 90906530 T ES90906530 T ES 90906530T ES 90906530 T ES90906530 T ES 90906530T ES 2087151 T3 ES2087151 T3 ES 2087151T3
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- liposome
- aprotic solvent
- lipids
- liposomes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Abstract
FORMULACIONES DE COMPUESTOS DE PARTICULAS LIPIDICAS Y LIPOSOMAS SE PREPARAN DISOLVIENDO EN UNA SOLUCION DE LIPIDOS FORMADORES DE LIPOSOMAS EN UN SOLVENTE APROTICO COMO EL DMSO, QUE CONTIENE OPCIONALMENTE UNA CANTIDAD SOLUBILIZABLE EN LIPIDOS DE UN ALCANOL INFERIOR, E INYECTANDO LA SOLUCION RESULTANTE EN UNA SOLUCION ACUOSA. LA SUSPENSION DE PARTICULA LIPIDICA O DE LIPOSOMAS RESULTANTE PUEDE ENTONCES DIALIZARSE O BIEN CONCENTRARSE. ESTE METODO ES ESPECIALMENTE UTIL PARA COMPUESTOS QUE SON POCO SOLUBLES EN SOLUCION ACUOSA, PERO ES GENERALMENTE UTIL PARA CUALQUIER COMPUESTO O COMBINACION DE COMPUESTOS QUE PUEDEN DISOLVERSE EN EL SOLVENTE APROTICO O LA MEZCLA DE SOLVENTE APROTICO/ALCANOL INFERIOR.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33260989A | 1989-03-31 | 1989-03-31 | |
US33405589A | 1989-04-05 | 1989-04-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2087151T3 true ES2087151T3 (es) | 1996-07-16 |
Family
ID=26988293
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90906530T Expired - Lifetime ES2087151T3 (es) | 1989-03-31 | 1990-03-28 | Preparacion de composiciones complejas de liposomas y lipidos. |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0467954B1 (es) |
JP (1) | JP2798302B2 (es) |
AT (1) | ATE137403T1 (es) |
AU (1) | AU638245B2 (es) |
CA (1) | CA2050679C (es) |
DE (1) | DE69026820T2 (es) |
DK (1) | DK0467954T3 (es) |
ES (1) | ES2087151T3 (es) |
HK (1) | HK1000912A1 (es) |
HU (1) | HU208070B (es) |
NO (1) | NO303205B1 (es) |
WO (1) | WO1990011780A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5178875A (en) * | 1991-01-14 | 1993-01-12 | The Board Of Regents, The University Of Texas System | Liposomal-polyene preliposomal powder and method for its preparation |
JPH0363298A (ja) * | 1989-07-31 | 1991-03-19 | Green Cross Corp:The | コロニー形成刺激因子・脂質複合体 |
FR2653015B1 (fr) * | 1989-10-12 | 1993-10-29 | Oreal | Composition cosmetique ou pharmaceutique pour application topique contenant au moins un derive retinouide et au moins un derive de pyrimidine, son utilisation comme medicament et procede de traitement correspondant. |
DE4238779A1 (de) * | 1992-11-12 | 1994-05-19 | Max Delbrueck Centrum | Lyotrophe Mesophasen und ihre Anwendung in der Pharmazie, der Kosmetik und der Dermatologie |
JP3479535B2 (ja) | 1993-07-08 | 2003-12-15 | ザ リポソーム カンパニー、インコーポレーテッド | リポソームの粒径を制御する方法 |
WO1995008918A1 (en) * | 1993-09-29 | 1995-04-06 | Gist-Brocades N.V. | A novel antifungal composition |
CA2223179A1 (en) * | 1995-06-07 | 1996-12-19 | Bob Dale Brown | Phosphonic acid-based cationic lipids |
DE69924004T2 (de) * | 1998-12-22 | 2006-02-09 | United States Of America Represented By The Secretary, Department Of Health & Human Services | Verabreichungssystem für wasserunlösliche arzneistoffe |
US6511676B1 (en) * | 1999-11-05 | 2003-01-28 | Teni Boulikas | Therapy for human cancers using cisplatin and other drugs or genes encapsulated into liposomes |
US7572833B2 (en) | 2000-10-26 | 2009-08-11 | Senju Pharmaceutical Co., Ltd. | Drug composition comprising dipeptidyl aldehyde derivative |
AU1999802A (en) * | 2000-12-01 | 2002-06-11 | Lawrence Boni | Preparation of large liposomes by infusion into peg |
IS6389A (is) * | 2001-08-31 | 2003-03-03 | Heraeus Kulzer Gmbh & Co. Kg | Reynsla af sýklalyfjahúðun skrokka, sem í eru örholrými, og einnig af þannig húðuðum skrokkum og notkun þeirra |
WO2008114274A1 (en) * | 2007-03-19 | 2008-09-25 | Fresenius Kabi Onclology Ltd. | Proliposomal and liposomal compositions |
RU2010123882A (ru) * | 2007-11-14 | 2011-12-20 | Те Риджентс Оф Те Юниверсити Оф Калифорния (Us) | Модифицированные стеринами амфифильные липиды |
HUE052571T2 (hu) * | 2008-09-27 | 2021-05-28 | Jina Pharmaceuticals Inc | Lipid alapú gyógyszerészeti készítmények helyi alkalmazáshoz |
JP6051157B2 (ja) | 2010-07-14 | 2016-12-27 | 中国医学科学院▲薬▼物研究所 | 一種インスリンの脂質複合物及び作製方法や製剤 |
EP3177269A4 (en) * | 2014-08-04 | 2018-02-28 | Zoneone Pharma, Inc. | Remote loading of sparingly water-soluble drugs into lipid vesicles |
CN113616798A (zh) * | 2021-09-06 | 2021-11-09 | 天津农学院 | 一种甲苯咪唑脂质复合物、制备方法和应用 |
CN115177590A (zh) * | 2022-04-20 | 2022-10-14 | 南昌大学抚州医学院 | 一种甲苯达唑类脂质体的制备方法及应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4588578A (en) * | 1983-08-08 | 1986-05-13 | The Liposome Company, Inc. | Lipid vesicles prepared in a monophase |
JPS60240634A (ja) | 1984-05-08 | 1985-11-29 | 関 則雄 | 飲み干し容易なコツプ |
US4619913A (en) * | 1984-05-29 | 1986-10-28 | Matrix Pharmaceuticals, Inc. | Treatments employing drug-containing matrices for introduction into cellular lesion areas |
AU598002B2 (en) * | 1986-07-15 | 1990-06-14 | Cilag Ltd. | Method of preparing single bilayered liposomes |
US4804539A (en) | 1986-07-28 | 1989-02-14 | Liposome Technology, Inc. | Ophthalmic liposomes |
US4839175A (en) * | 1986-07-28 | 1989-06-13 | Liposome Technology, Inc. | Liposomes with enhanced retention on mucosal tissue |
US4812312A (en) * | 1987-03-03 | 1989-03-14 | Board Of Regents Of The University Of Texas System | Liposome-incorporated nystatin |
NZ223660A (en) * | 1987-03-05 | 1990-11-27 | Liposome Co Inc | Low toxicity drug-lipid complexes; methods of making them; and method of determining their toxicity |
-
1990
- 1990-03-28 DE DE69026820T patent/DE69026820T2/de not_active Expired - Fee Related
- 1990-03-28 AU AU54345/90A patent/AU638245B2/en not_active Ceased
- 1990-03-28 ES ES90906530T patent/ES2087151T3/es not_active Expired - Lifetime
- 1990-03-28 EP EP90906530A patent/EP0467954B1/en not_active Expired - Lifetime
- 1990-03-28 WO PCT/US1990/001646 patent/WO1990011780A1/en active IP Right Grant
- 1990-03-28 JP JP2506114A patent/JP2798302B2/ja not_active Expired - Fee Related
- 1990-03-28 DK DK90906530.2T patent/DK0467954T3/da active
- 1990-03-28 HU HU903559A patent/HU208070B/hu not_active IP Right Cessation
- 1990-03-28 CA CA002050679A patent/CA2050679C/en not_active Expired - Fee Related
- 1990-03-28 AT AT90906530T patent/ATE137403T1/de not_active IP Right Cessation
-
1991
- 1991-09-27 NO NO913816A patent/NO303205B1/no unknown
-
1997
- 1997-12-19 HK HK97102512A patent/HK1000912A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO303205B1 (no) | 1998-06-15 |
EP0467954A4 (en) | 1992-06-03 |
EP0467954B1 (en) | 1996-05-01 |
HU903559D0 (en) | 1991-12-30 |
DE69026820D1 (de) | 1996-06-05 |
JP2798302B2 (ja) | 1998-09-17 |
HU208070B (en) | 1993-08-30 |
EP0467954A1 (en) | 1992-01-29 |
AU638245B2 (en) | 1993-06-24 |
DE69026820T2 (de) | 1996-11-28 |
CA2050679C (en) | 1998-09-22 |
DK0467954T3 (da) | 1996-05-28 |
JPH04506207A (ja) | 1992-10-29 |
NO913816D0 (no) | 1991-09-27 |
NO913816L (no) | 1991-11-26 |
CA2050679A1 (en) | 1990-10-01 |
HK1000912A1 (en) | 1998-05-08 |
ATE137403T1 (de) | 1996-05-15 |
AU5434590A (en) | 1990-11-05 |
WO1990011780A1 (en) | 1990-10-18 |
HUT59818A (en) | 1992-07-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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