KR880009636A - 리포좀 조성물 및 그의 제조방법 - Google Patents
리포좀 조성물 및 그의 제조방법 Download PDFInfo
- Publication number
- KR880009636A KR880009636A KR1019880001950A KR880001950A KR880009636A KR 880009636 A KR880009636 A KR 880009636A KR 1019880001950 A KR1019880001950 A KR 1019880001950A KR 880001950 A KR880001950 A KR 880001950A KR 880009636 A KR880009636 A KR 880009636A
- Authority
- KR
- South Korea
- Prior art keywords
- composition
- liposome
- anionic surfactant
- acyl group
- drug
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도, 제2도 및 제3도는 실험예 1-2에 있어서, 쥐에서의 6-CF-포획 리포좀 조성물의 정맥내 투여후 시간과 6-CF 혈중 농도 사이의 관계를 나타낸다.
Claims (12)
- 그 막이, 아실기가 불포화아실기인 인지질 및 37℃이상의 크라프트 점을 갖는 음이온성 계면활성제로 구성된 것인, 리포좀내에 약제가 포획되어 있는 리포좀 조성물.
- 제1항에 있어서, 리포좀막의 상전이 온도가 약 37∼60℃ 범위임을 특징으로 하는 조성물.
- 제1항에 있어서, 음이온성 계면활성제가 다음 일반식으로 나타내지는 것임을 특징으로 하는 조성물.[상기 식중, R 은 설페이트기에 의해 치환될 수도 있는 12 이상의 탄소원자를 갖는 알킬기이고; X 는--또는이고; Y1는,또는이고; Y1는-또는이고; Z 는 -SO3 -M+또는 -SO4 -M+(M 은 알칼리 금속원소이다)이고; m 은 O(직접 결합) 또는 1이고: n 은 O(직접결합)∼2의 정수이며; 단 X 가 -CONH- 또는이면 Y2는 O(직접결합)이고 X 가이면 n 은 O(직접 교환)이다.]
- 제1항에 있어서, 음이온성 계면활성제가 아실타우린 또는 아실메틸타우린의 염임을 특징으로 하는 조성물.
- 제1항에 있어서, 약제가 옥탄올과 물사이에서의 그의 분배계수의 대수가 10이하인 것임을 특징으로 하는 조성물.
- 제1항에 있어서, 약제가 항종양제, 림포킨, 생리적으로 활성인 펩티드, 항생제, 비타민, 원생동물박멸제, 효소,혈액응고방지제, 항알레르기체, 면역 활성화제, 순환계의 약제 도는 대사활성화제임을 특징으로 하는 조성물.
- 제6항에 있어서, 항종양제가 백금 화합물임을 특징으로 하는 조성물.
- 제7항에 있어서, 배금 화합물이 시스플라틴임을 특징으로 하는 조성물.
- 제6항에 있어서, 항종양제가 그의 막이 약 40∼55℃의 상전이온도를 갖는 리포좀내에 포획되어 있음을 특징으로 하는 조성물.
- (1) 37℃이상의 크라프트 점을 갖는 음이온성 계면활성제를 그 임계 미셀 농도 이상의 온도로 함유하는 수성 매질을 제조하고, (2) 생성된 수성 매질을 그의 아실기가 포화아실기인 인지질과 혼합하여 에멀션 또는 현탁액을 제조하고, 공정(1) 및/또는 (2)에서 유효량의 약제를 첨가하고, (3) 생성된 에멀션 또는 현탁액을 리포좀 소포를 제조하는데 이용하여 리포좀 막이 상기 계면활성제 및 인지질로 구성되도록 함을 특징으로 하는 약제를 포획하는 리포좀 조성물의 제조방법.
- 제10항에 있어서, 리포좀 소포를 REV, MLV, SUV, 또는 SPLV 의 제조방법에 의해 제조함을 특징으로 하는 제조방법.
- 제10항에 있어서, 음이온성 계면활성제의 양이 인지질 100 중량부당 약 0.5∼50 중량부의 범위내에 있음을 특징으로 하는 제조방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62-43442 | 1987-02-25 | ||
JP4344287 | 1987-02-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR880009636A true KR880009636A (ko) | 1988-10-04 |
Family
ID=12663814
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019880001950A KR880009636A (ko) | 1987-02-25 | 1988-02-24 | 리포좀 조성물 및 그의 제조방법 |
Country Status (9)
Country | Link |
---|---|
US (1) | US5019394A (ko) |
EP (1) | EP0280492B1 (ko) |
KR (1) | KR880009636A (ko) |
CN (1) | CN88100965A (ko) |
AT (1) | ATE71834T1 (ko) |
CA (1) | CA1322171C (ko) |
DE (1) | DE3867866D1 (ko) |
DK (1) | DK86988A (ko) |
HU (1) | HU203278B (ko) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101309033B1 (ko) * | 2012-03-16 | 2013-09-17 | 유우영 | 무복계면물질 및 무수무복계면물질의 제조방법 |
Families Citing this family (38)
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US5888519A (en) * | 1988-06-02 | 1999-03-30 | The United States Of America As Represented By The Secretary Of The Army | Encapsulated high-concentration lipid a compositions as immunogenic agents to produce human antibodies to prevent or treat gram-negative bacterial infections |
EP0440742B1 (en) * | 1988-10-27 | 1997-01-15 | The Regents Of The University Of Minnesota | Liposome immunoadjuvants containing il-2 |
CA2033714A1 (en) * | 1990-01-25 | 1991-07-26 | Alberto Ferro | Pharmaceutical preparations |
DE69107844T2 (de) * | 1990-04-18 | 1995-08-10 | Takeda Chemical Industries, Ltd., Osaka | Liposomenzusammensetzung. |
WO1992003122A1 (de) * | 1990-08-24 | 1992-03-05 | Gregor Cevc | Präparat zur wirkstoffapplikation in kleinsttröpfchenform |
US6165500A (en) * | 1990-08-24 | 2000-12-26 | Idea Ag | Preparation for the application of agents in mini-droplets |
WO1992003123A1 (en) * | 1990-08-28 | 1992-03-05 | Liposome Technology, Inc. | Liposome alternative bilayer formulations |
ES2089226T3 (es) * | 1990-09-06 | 1996-10-01 | Johnson & Son Inc S C | Procedimiento para estabilizar liposomas y composiciones que los contienen. |
FR2677248B1 (fr) * | 1991-06-04 | 1995-06-16 | Lvmh Rech Gie | Composition cosmetique ou pharmaceutique, notamment dermatologique, contenant un extrait de brunelle. |
US5593671A (en) * | 1994-07-01 | 1997-01-14 | American Cyanamid Company | Method of attenuating lung capillary leak in a mammal |
US6077545A (en) | 1995-10-30 | 2000-06-20 | Matrix Pharmaceuticals, Inc. | Process and composition for therapeutic cisplatin (CDDP) |
ES2373861T3 (es) | 1997-09-18 | 2012-02-09 | Pacira Pharmaceuticals, Inc. | Composiciones anestésicas liposomiales de liberación sostenida. |
EP1030652B1 (en) | 1997-11-14 | 2012-04-25 | Pacira Pharmaceuticals, Inc. | Production of multivesicular liposomes |
ES2325141T3 (es) | 1998-07-17 | 2009-08-26 | Pacira Pharmaceuticals, Inc. | Composiciones biodegradables para la liberacion controlada de sustancias encapsuladas. |
EP1140021B1 (en) | 1998-12-23 | 2004-08-04 | Idea Ag | Improved formulation for topical non-invasive application in vivo |
EP1031347B1 (en) | 1999-01-27 | 2002-04-17 | Idea Ag | Transnasal transport/immunisation with highly adaptable carriers |
DE69901377T2 (de) | 1999-01-27 | 2003-01-02 | Idea Ag | Nichtinvasive Impfung durch die Haut |
IL158819A0 (en) * | 2001-05-31 | 2004-05-12 | Skyepharma Inc | Encapsulation of nanosuspensions in liposomes and microspheres |
US20040034336A1 (en) * | 2002-08-08 | 2004-02-19 | Neal Scott | Charged liposomes/micelles with encapsulted medical compounds |
US7517342B2 (en) * | 2003-04-29 | 2009-04-14 | Boston Scientific Scimed, Inc. | Polymer coated device for electrically medicated drug delivery |
WO2005088655A1 (en) * | 2004-03-12 | 2005-09-22 | The Provost Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | A magnetoresistive medium |
US8128916B2 (en) * | 2005-06-16 | 2012-03-06 | L'oréal | Aqueous fatty quaternary amine-containing carrier systems for water-insoluble materials |
US8128917B2 (en) | 2005-06-16 | 2012-03-06 | L'oréal | Aqueous polyamine-containing carrier systems for water-insoluble materials |
US20060292100A1 (en) * | 2005-06-16 | 2006-12-28 | L'oreal | Aqueous phospholipid-containing carrier systems for water-insoluble materials |
US8128915B2 (en) * | 2005-06-16 | 2012-03-06 | L'oréal | Aqueous fatty monoamine-containing carrier systems for water -insoluble materials |
US20070178049A1 (en) * | 2005-12-20 | 2007-08-02 | Verus Pharmaceuticals, Inc. | Systems and methods for the delivery of corticosteroids having an enhanced pharmacokinetic profile |
US20070197486A1 (en) * | 2005-12-20 | 2007-08-23 | Verus Pharmaceuticals, Inc. | Methods and systems for the delivery of corticosteroids |
US20070160542A1 (en) * | 2005-12-20 | 2007-07-12 | Verus Pharmaceuticals, Inc. | Methods and systems for the delivery of corticosteroids having an enhanced pharmacokinetic profile |
US20070185066A1 (en) * | 2005-12-20 | 2007-08-09 | Verus Pharmaceuticals, Inc. | Systems and methods for the delivery of corticosteroids |
US20070249572A1 (en) * | 2005-12-20 | 2007-10-25 | Verus Pharmaceuticals, Inc. | Systems and methods for the delivery of corticosteroids |
JP2009526858A (ja) * | 2006-02-15 | 2009-07-23 | ティカ レーケメデル アーベー | コルチコステロイド溶液を製造する方法 |
EP2187869B1 (en) * | 2007-08-17 | 2015-10-14 | Celator Pharmaceuticals, Inc. | Improved platinum drug formulations |
FR2924430B1 (fr) * | 2007-11-30 | 2010-03-19 | Univ Bordeaux 2 | Procede de preparation de nanoparticules a base de molecules ou macromolecules amphiphiles fonctionnelles et leur utilisation |
JP4395537B2 (ja) * | 2008-04-09 | 2010-01-13 | 株式会社資生堂 | ベシクル及びそれを含む化粧料 |
CN104655542B (zh) * | 2015-01-05 | 2017-06-20 | 北京市医疗器械检验所 | 一种防护产品检测用合成血液及其配制方法 |
US11357727B1 (en) | 2021-01-22 | 2022-06-14 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
US11278494B1 (en) | 2021-01-22 | 2022-03-22 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
US11033495B1 (en) | 2021-01-22 | 2021-06-15 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
Family Cites Families (12)
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US4217344A (en) * | 1976-06-23 | 1980-08-12 | L'oreal | Compositions containing aqueous dispersions of lipid spheres |
US4235871A (en) * | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
IL64397A0 (en) * | 1981-01-07 | 1982-02-28 | Weder Hans G | Process for the preparation of liposomal medicaments |
US4670185A (en) * | 1982-07-19 | 1987-06-02 | Lion Corporation | Aqueous vesicle dispersion having surface charge |
EP0102324A3 (de) * | 1982-07-29 | 1984-11-07 | Ciba-Geigy Ag | Lipide und Tenside in wässriger Phase |
JPS6058915A (ja) * | 1983-09-12 | 1985-04-05 | Fujisawa Pharmaceut Co Ltd | 薬物含有脂質小胞体製剤 |
JPS6072830A (ja) * | 1983-09-29 | 1985-04-24 | Kao Corp | ベシクル用組成物 |
JPS60136508A (ja) * | 1983-12-26 | 1985-07-20 | Kao Corp | ベシクル用組成物 |
US4610868A (en) * | 1984-03-20 | 1986-09-09 | The Liposome Company, Inc. | Lipid matrix carriers for use in drug delivery systems |
PH26160A (en) * | 1985-08-19 | 1992-03-18 | Univ Texas | Pharmaceutical compositions consisting of acylated phospholipids |
US5041581A (en) * | 1985-10-18 | 1991-08-20 | The University Of Texas System Board Of Regents | Hydrophobic cis-platinum complexes efficiently incorporated into liposomes |
US4837028A (en) * | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
-
1988
- 1988-02-19 DK DK086988A patent/DK86988A/da unknown
- 1988-02-22 AT AT88301486T patent/ATE71834T1/de not_active IP Right Cessation
- 1988-02-22 EP EP19880301486 patent/EP0280492B1/en not_active Expired - Lifetime
- 1988-02-22 DE DE8888301486T patent/DE3867866D1/de not_active Expired - Fee Related
- 1988-02-24 US US07/159,945 patent/US5019394A/en not_active Expired - Fee Related
- 1988-02-24 KR KR1019880001950A patent/KR880009636A/ko not_active Application Discontinuation
- 1988-02-24 HU HU88892A patent/HU203278B/hu not_active IP Right Cessation
- 1988-02-24 CA CA000559633A patent/CA1322171C/en not_active Expired - Fee Related
- 1988-02-25 CN CN198888100965A patent/CN88100965A/zh not_active Withdrawn
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101309033B1 (ko) * | 2012-03-16 | 2013-09-17 | 유우영 | 무복계면물질 및 무수무복계면물질의 제조방법 |
Also Published As
Publication number | Publication date |
---|---|
EP0280492A2 (en) | 1988-08-31 |
CA1322171C (en) | 1993-09-14 |
EP0280492B1 (en) | 1992-01-22 |
HU203278B (en) | 1991-07-29 |
DK86988A (da) | 1988-08-26 |
HUT52943A (en) | 1990-09-28 |
ATE71834T1 (de) | 1992-02-15 |
DE3867866D1 (de) | 1992-03-05 |
US5019394A (en) | 1991-05-28 |
EP0280492A3 (en) | 1989-10-04 |
CN88100965A (zh) | 1988-09-07 |
DK86988D0 (da) | 1988-02-19 |
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WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |