ES2074878T3 - Polvo preliposomal de polieno liposomal y metodo para su preparacion. - Google Patents
Polvo preliposomal de polieno liposomal y metodo para su preparacion.Info
- Publication number
- ES2074878T3 ES2074878T3 ES92905027T ES92905027T ES2074878T3 ES 2074878 T3 ES2074878 T3 ES 2074878T3 ES 92905027 T ES92905027 T ES 92905027T ES 92905027 T ES92905027 T ES 92905027T ES 2074878 T3 ES2074878 T3 ES 2074878T3
- Authority
- ES
- Spain
- Prior art keywords
- solution
- polyene
- powder
- combining
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
- Y10T428/2985—Solid-walled microcapsule from synthetic polymer
Abstract
SE DESCRIBE UN METODO PARA PREPARAR UN POLVO PREICO ESTABLE QUE, CUANDO SE HIDRATA CON AGUA O CON UNA SOLUCION SALINA, FORMA UNA SOLUCION DE LIPOSOMAS QUE CONTIENE UN MEDICAMENTO POLIENICO, COMO ES EL NYSTATIN. EL METODO REQUIERE LOS PASOS DE: COMBINAR, AL MENOS, UN FOSFOLIPIDO CON UN PRIMER DISOLVENTE ORGANICO, PARA FORMAR UNA PRIMERA SOLUCION; AÑADIR UNA CANTIDAD CLARIFICADORA DE AGUA A LA PRIMERA SOLUCION; COMBINAR UN POLIENO CON UN SEGUNDO DISOLVENTE ORGANICO PARA FORMAR UNA SEGUNDA SOLUCION; COMBINAR LA PRIMERA Y LA SEGUNDA SOLUCION PARA PRODUCIR UNA SOLUCION BASICAMENTE CLARA, Y DESPUES RETIRAR LOS DISOLVENTES ORGANICOS, QUEDANDO EL POLVO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/640,707 US5178875A (en) | 1991-01-14 | 1991-01-14 | Liposomal-polyene preliposomal powder and method for its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2074878T3 true ES2074878T3 (es) | 1995-09-16 |
Family
ID=24569381
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92905027T Expired - Lifetime ES2074878T3 (es) | 1991-01-14 | 1992-01-10 | Polvo preliposomal de polieno liposomal y metodo para su preparacion. |
Country Status (11)
Country | Link |
---|---|
US (2) | US5178875A (es) |
EP (1) | EP0567582B1 (es) |
JP (1) | JP3267611B2 (es) |
AT (1) | ATE122559T1 (es) |
AU (1) | AU663074B2 (es) |
CA (1) | CA2099771C (es) |
DE (1) | DE69202559T2 (es) |
DK (1) | DK0567582T3 (es) |
ES (1) | ES2074878T3 (es) |
GR (1) | GR3017118T3 (es) |
WO (1) | WO1992011842A1 (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5830498A (en) * | 1987-10-16 | 1998-11-03 | Board Of Regents, The University Of Texas System | Liposomal-polyene preliposomal powder and method for its preparation |
US5178875A (en) * | 1991-01-14 | 1993-01-12 | The Board Of Regents, The University Of Texas System | Liposomal-polyene preliposomal powder and method for its preparation |
US5417978A (en) * | 1993-07-29 | 1995-05-23 | Board Of Regents, The University Of Texas System | Liposomal antisense methyl phosphonate oligonucleotides and methods for their preparation and use |
US5902604A (en) * | 1995-06-06 | 1999-05-11 | Board Of Regents, The University Of Texas System | Submicron liposome suspensions obtained from preliposome lyophilizates |
US5855911A (en) * | 1995-08-29 | 1999-01-05 | Board Of Regents, The University Of Texas System | Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides |
US6977244B2 (en) | 1996-10-04 | 2005-12-20 | Board Of Regents, The University Of Texas Systems | Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides |
GB2326337A (en) * | 1997-06-20 | 1998-12-23 | Phares Pharma Holland | Homogeneous lipid compositions for drug delivery |
US6287590B1 (en) * | 1997-10-02 | 2001-09-11 | Esperion Therapeutics, Inc. | Peptide/lipid complex formation by co-lyophilization |
US7704962B1 (en) | 1997-10-03 | 2010-04-27 | Board Of Regents, The University Of Texas System | Small oligonucleotides with anti-tumor activity |
US7285288B1 (en) | 1997-10-03 | 2007-10-23 | Board Of Regents, The University Of Texas System | Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides |
US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
JP2002509102A (ja) * | 1998-01-16 | 2002-03-26 | バイオミラ・ユーエスエイ・インコーポレイテッド | リポマトリックス製剤 |
EP1059941B1 (en) * | 1998-03-05 | 2004-05-26 | Phares Pharmaceutical Research N.V. | Pharmaceutical compositions and their use |
US6106701A (en) * | 1998-08-25 | 2000-08-22 | Betzdearborn Inc. | Deasphalting process |
US6613352B2 (en) | 1999-04-13 | 2003-09-02 | Universite De Montreal | Low-rigidity liposomal formulation |
US6413537B1 (en) | 2000-03-10 | 2002-07-02 | Wisconsin Alumni Research Foundation | Nystatin formulation having reduced toxicity |
US20040082521A1 (en) * | 2002-03-29 | 2004-04-29 | Azaya Therapeutics Inc. | Novel formulations of digitalis glycosides for treating cell-proliferative and other diseases |
AU2003287526A1 (en) * | 2002-11-06 | 2004-06-03 | Protein-stabilized liposomal formulations of pharmaceutical agents | |
EP1874793A4 (en) | 2005-04-15 | 2008-12-24 | Univ Texas | DISTRIBUTION OF SIRNA BY NEUTRAL LIPID COMPOSITIONS |
JP2009519250A (ja) * | 2005-12-08 | 2009-05-14 | ワイス | リポソーム組成物 |
US20110250262A1 (en) | 2008-12-24 | 2011-10-13 | Biomedcore, Inc. | Method for producing liposome and method for dissolving cholesterol |
JP5771366B2 (ja) | 2009-09-02 | 2015-08-26 | 株式会社バイオメッドコア | リポソーム製造装置及び方法 |
WO2013142184A1 (en) | 2012-03-19 | 2013-09-26 | Yale University | Antimicrobial compositions and methods |
JP2016079351A (ja) * | 2014-10-22 | 2016-05-16 | 株式会社デンソー | 複合蓄熱材 |
JP6557935B2 (ja) * | 2014-11-18 | 2019-08-14 | 国立研究開発法人物質・材料研究機構 | 多孔性粒子の製造方法 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1575343A (en) * | 1977-05-10 | 1980-09-17 | Ici Ltd | Method for preparing liposome compositions containing biologically active compounds |
CH621479A5 (es) * | 1977-08-05 | 1981-02-13 | Battelle Memorial Institute | |
FR2416008A1 (fr) * | 1978-02-02 | 1979-08-31 | Oreal | Lyophilisats de liposomes |
US4744989A (en) * | 1984-02-08 | 1988-05-17 | E. R. Squibb & Sons, Inc. | Method of preparing liposomes and products produced thereby |
EP0152379A3 (de) * | 1984-02-15 | 1986-10-29 | Ciba-Geigy Ag | Verfahren zur Herstellung von pharmazeutischen Zusammensetzungen enthaltend unilamellare Liposomen |
EP0158441B2 (en) * | 1984-03-08 | 2001-04-04 | Phares Pharmaceutical Research N.V. | Liposome-forming composition |
JPS60208910A (ja) * | 1984-03-31 | 1985-10-21 | Green Cross Corp:The | 水難溶性薬物・リン脂質複合体の製造方法 |
US4880635B1 (en) * | 1984-08-08 | 1996-07-02 | Liposome Company | Dehydrated liposomes |
JPS6150912A (ja) * | 1984-08-16 | 1986-03-13 | Shionogi & Co Ltd | リポソ−ム製剤の製造法 |
JPS6176414A (ja) * | 1984-09-21 | 1986-04-18 | Shionogi & Co Ltd | リポソーム製剤の製法 |
CA1260393A (en) * | 1984-10-16 | 1989-09-26 | Lajos Tarcsay | Liposomes of synthetic lipids |
US4897355A (en) * | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
US4830858A (en) * | 1985-02-11 | 1989-05-16 | E. R. Squibb & Sons, Inc. | Spray-drying method for preparing liposomes and products produced thereby |
CA1256372A (en) * | 1985-04-11 | 1989-06-27 | Koichiro Miyazima | Process for producing liposome composition |
US4766046A (en) * | 1985-09-27 | 1988-08-23 | Liposome Technology, Inc. | Stabilized liposome/amphotericin composition and method |
US4812312A (en) * | 1987-03-03 | 1989-03-14 | Board Of Regents Of The University Of Texas System | Liposome-incorporated nystatin |
NZ223660A (en) * | 1987-03-05 | 1990-11-27 | Liposome Co Inc | Low toxicity drug-lipid complexes; methods of making them; and method of determining their toxicity |
US4963362A (en) * | 1987-08-07 | 1990-10-16 | Regents Of The University Of Minnesota | Freeze-dried liposome mixture containing cyclosporin |
US5178875A (en) * | 1991-01-14 | 1993-01-12 | The Board Of Regents, The University Of Texas System | Liposomal-polyene preliposomal powder and method for its preparation |
US4950432A (en) * | 1987-10-16 | 1990-08-21 | Board Of Regents, The University Of Texas System | Polyene microlide pre-liposomal powders |
US4994213A (en) * | 1988-05-17 | 1991-02-19 | Liposome Technology, Inc. | Method of preparing lipid structures |
IL90561A (en) * | 1988-06-08 | 1993-08-18 | Fountain Pharm Inc | Method for making solvent dilution microcarriers |
US4999199A (en) * | 1988-11-10 | 1991-03-12 | Board Of Regents, The University Of Texas System | Pharmaceutical formulations: liposomes incorporating aromatic polyene antibiotics |
US4935171A (en) * | 1989-01-27 | 1990-06-19 | Vestar, Inc. | Method for vesicle formation |
AU638245B2 (en) * | 1989-03-31 | 1993-06-24 | Regents Of The University Of California, The | Preparation of liposome and lipid complex compositions |
-
1991
- 1991-01-14 US US07/640,707 patent/US5178875A/en not_active Expired - Fee Related
-
1992
- 1992-01-10 JP JP50531092A patent/JP3267611B2/ja not_active Expired - Fee Related
- 1992-01-10 AT AT92905027T patent/ATE122559T1/de not_active IP Right Cessation
- 1992-01-10 CA CA002099771A patent/CA2099771C/en not_active Expired - Fee Related
- 1992-01-10 DE DE69202559T patent/DE69202559T2/de not_active Expired - Fee Related
- 1992-01-10 EP EP92905027A patent/EP0567582B1/en not_active Expired - Lifetime
- 1992-01-10 DK DK92905027.6T patent/DK0567582T3/da active
- 1992-01-10 AU AU12527/92A patent/AU663074B2/en not_active Ceased
- 1992-01-10 ES ES92905027T patent/ES2074878T3/es not_active Expired - Lifetime
- 1992-01-10 WO PCT/US1992/000160 patent/WO1992011842A1/en active IP Right Grant
-
1995
- 1995-08-16 GR GR950402237T patent/GR3017118T3/el unknown
-
1997
- 1997-11-26 US US08/979,578 patent/US5965158A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US5965158A (en) | 1999-10-12 |
CA2099771C (en) | 2002-04-23 |
ATE122559T1 (de) | 1995-06-15 |
JP3267611B2 (ja) | 2002-03-18 |
DE69202559T2 (de) | 1996-01-11 |
US5178875A (en) | 1993-01-12 |
DK0567582T3 (da) | 1995-10-02 |
AU663074B2 (en) | 1995-09-28 |
EP0567582A1 (en) | 1993-11-03 |
DE69202559D1 (de) | 1995-06-22 |
JPH06509547A (ja) | 1994-10-27 |
WO1992011842A1 (en) | 1992-07-23 |
CA2099771A1 (en) | 1992-07-15 |
GR3017118T3 (en) | 1995-11-30 |
EP0567582B1 (en) | 1995-05-17 |
AU1252792A (en) | 1992-08-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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