CY2366B1 - Process for the production of powdered pulmonary surfactant preparations. - Google Patents

Process for the production of powdered pulmonary surfactant preparations.

Info

Publication number
CY2366B1
CY2366B1 CY0300048A CY0300048A CY2366B1 CY 2366 B1 CY2366 B1 CY 2366B1 CY 0300048 A CY0300048 A CY 0300048A CY 0300048 A CY0300048 A CY 0300048A CY 2366 B1 CY2366 B1 CY 2366B1
Authority
CY
Cyprus
Prior art keywords
pulmonary surfactant
production
powdered
surfactant preparations
powdered pulmonary
Prior art date
Application number
CY0300048A
Other languages
English (en)
Inventor
Klaus Eistetter
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19602332A external-priority patent/DE19602332A1/de
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of CY2366B1 publication Critical patent/CY2366B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0082—Lung surfactant, artificial mucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Zoology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CY0300048A 1996-01-24 2003-06-24 Process for the production of powdered pulmonary surfactant preparations. CY2366B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19602332A DE19602332A1 (de) 1996-01-24 1996-01-24 Verfahren zur Herstellung von pulverförmigen Lungensurfactant-Zubereitungen
EP96103442 1996-03-06

Publications (1)

Publication Number Publication Date
CY2366B1 true CY2366B1 (en) 2004-06-04

Family

ID=26022286

Family Applications (1)

Application Number Title Priority Date Filing Date
CY0300048A CY2366B1 (en) 1996-01-24 2003-06-24 Process for the production of powdered pulmonary surfactant preparations.

Country Status (15)

Country Link
US (1) US6315983B1 (pt)
EP (1) EP0877602B1 (pt)
JP (1) JP3725166B2 (pt)
KR (1) KR100449789B1 (pt)
AT (1) ATE212220T1 (pt)
CA (1) CA2244767C (pt)
CY (1) CY2366B1 (pt)
CZ (1) CZ292186B6 (pt)
DE (1) DE59706180D1 (pt)
DK (1) DK0877602T3 (pt)
ES (1) ES2171883T3 (pt)
PT (1) PT877602E (pt)
TR (1) TR199801408T2 (pt)
UA (1) UA59358C2 (pt)
WO (1) WO1997026863A1 (pt)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030203036A1 (en) 2000-03-17 2003-10-30 Gordon Marc S. Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
JP2001507702A (ja) * 1996-12-31 2001-06-12 インヘイル・セラピューティックス・システムズ・インコーポレテッド 親水性賦形剤を有する疎水性薬剤の水性懸濁液を噴霧乾燥させる方法およびその方法によって作製された組成物
US20060165606A1 (en) * 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6565885B1 (en) * 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
ES2289823T3 (es) * 1998-08-25 2008-02-01 Advanced Inhalation Research, Inc. Formulaciones proteicas estables secadas por atomizacion.
EP1767195A3 (en) * 1998-08-25 2007-04-04 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
EP1131055B1 (en) * 1998-11-10 2005-11-09 ALTANA Pharma AG Treatment set containing lungsurfactant compositions
AU5400000A (en) * 1999-06-11 2001-01-02 Byk Gulden Lomberg Chemische Fabrik Gmbh Pharmaceutical preparation containing modifications of surfactant protein b (sp-b) and surfactant protein c (sp-c)
WO2001013892A2 (en) * 1999-08-25 2001-03-01 Advanced Inhalation Research, Inc. Large porous particles by spray-drying
US6749835B1 (en) * 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
WO2001019392A1 (en) 1999-09-16 2001-03-22 Byk Gulden Lomberg Chemische Fabrik Gmbh Combination of c1-inh and lung surfactant for the treatment of respiratory disorders
DE19957898A1 (de) * 1999-12-01 2001-06-07 Byk Gulden Lomberg Chem Fab Neue Verwendung von Lungensurfactant
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
AU6124601A (en) 2000-05-10 2001-11-20 Alliance Pharmaceutical Corporation Phospholipid-based powders for drug delivery
US7575761B2 (en) 2000-06-30 2009-08-18 Novartis Pharma Ag Spray drying process control of drying kinetics
DE50214446D1 (de) 2001-10-11 2010-07-01 Nycomed Gmbh Neue verwendung von lungensurfactant
WO2003043603A1 (en) * 2001-11-20 2003-05-30 Advanced Inhalation Research, Inc. Particulate compositions for improving solubility of poorly soluble agents
MXPA04005865A (es) 2001-12-19 2004-09-13 Nektar Therapeutics Suministro de aminoglucosidos a los pulmones.
US20030170223A1 (en) * 2002-02-01 2003-09-11 Board Of Trustees Of Michigan State University Pulmonary vasodilator surfactant compositions and method of use
WO2003077891A1 (fr) * 2002-03-18 2003-09-25 Yamanouchi Pharmaceutical Co., Ltd. Compositions medicales en poudre pour inhalation et procede de production de celles-ci
US20040184995A1 (en) * 2003-03-17 2004-09-23 Yamanouchi Pharmaceutical Co., Ltd. Novel dry powder inhalation for lung-delivery and manufacturing method thereof
CA2567334A1 (en) * 2004-05-20 2005-12-08 Discovery Laboratories, Inc. Methods , systems and devices for noninvasive pulmonary delivery
ATE457736T1 (de) 2004-08-06 2010-03-15 Nycomed Gmbh Zusammensetzung aus einem pulmonalen surfactant und einem von tnf stammenden peptid
US8337815B2 (en) 2004-12-23 2012-12-25 Discovery Laboratories, Inc. Pulmonary surfactant formulations
KR100770362B1 (ko) * 2004-12-30 2007-10-26 (주)두비엘 분무건조 고분자형 콜렉틴족 단백질 및 그의 제조방법
US8028697B2 (en) 2005-04-28 2011-10-04 Trudell Medical International Ventilator circuit and method for the use thereof
EP2009023A1 (en) * 2007-06-04 2008-12-31 Rentschler Beteiligungs GmbH Novel peptides and their use for the treatment of edema
MX2010010139A (es) 2008-03-17 2011-02-21 Discovery Lab Inc Adaptador de circuito de ventilacion y sistema proximo de suministro en aerosol.
ES2402241T3 (es) 2008-10-22 2013-04-30 Trudell Medical International Sistema de suministro de aerosol modular
WO2010068754A2 (en) 2008-12-10 2010-06-17 Paka Pulmonary Pharmaceuticals, Inc. Methods and compositions for delivery of medicaments to the lungs
PT2410981T (pt) * 2009-03-26 2017-05-25 Pulmatrix Inc Formulações em pó seco e métodos para tratar doenças pulmonares
EP2308489B1 (en) * 2009-10-05 2014-01-01 Nutri-Fit GmbH & Co. KG Compositions for use in treating or preventing metabolic stress-induced lung injury and methods for increasing physical capacity of mammalian livestock
MX2013001936A (es) * 2010-08-23 2013-03-08 Takeda Gmbh Particulas humidificadas que comprenden una sustancia terapeuticamente activa.
WO2013149074A1 (en) 2012-03-28 2013-10-03 Discovery Laboratories, Inc. Lyophilization of synthetic liposomal pulmonary surfactant
AU2015226289B8 (en) 2014-03-05 2019-10-31 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Device for providing a constant amount of aerosol
AU2015226287B2 (en) 2014-03-05 2019-01-31 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Humidifier for humidifying an aerosol
CA2940351A1 (en) * 2014-03-18 2015-09-24 Apeptico Forschung Und Entwicklung Gmbh Dry-powder peptide medicament
JP7240178B2 (ja) * 2016-06-24 2023-03-15 シヴィタス セラピューティクス、インコーポレイテッド 吸入用サーファクタント製剤
JP7335263B2 (ja) 2017-12-21 2023-08-29 キウィタス セラピューティクス，インコーポレイテッド 吸入のための界面活性剤製剤
MX2020006633A (es) * 2017-12-21 2021-01-15 Civitas Therapeutics Inc Formulaciones de surfactantes para inhalacion.

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58183621A (ja) * 1982-04-22 1983-10-26 Teijin Ltd 肺表面活性物質を有効成分とする粉末剤の調製法
DE3229179C2 (de) 1982-08-05 1986-04-17 A. Nattermann & Cie GmbH, 5000 Köln Lungensurfactant
JPS59164724A (ja) 1983-03-10 1984-09-17 Tokyo Tanabe Co Ltd サ−フアクタント及びそれを含有する呼吸窮迫症候群治療剤
US5164369A (en) 1988-01-06 1992-11-17 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US5260273A (en) 1988-01-06 1993-11-09 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
AU638474B2 (en) 1989-07-11 1993-07-01 Genentech Inc. Surfactant compositions and methods
IN172208B (pt) * 1990-04-02 1993-05-01 Sint Sa
DE69132211T2 (de) 1990-10-17 2000-11-23 Liposome Co Inc Synthetische oberflächenaktive agentien auf der lunge
US6582728B1 (en) * 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
EP0655237A1 (de) * 1993-11-27 1995-05-31 Hoechst Aktiengesellschaft Medizinische Aerosolformulierung
WO1995024183A1 (en) 1994-03-07 1995-09-14 Inhale Therapeutic Systems Methods and compositions for pulmonary delivery of insulin
US6051256A (en) 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
US5780014A (en) 1995-04-14 1998-07-14 Inhale Therapeutic Systems Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin
US6019968A (en) 1995-04-14 2000-02-01 Inhale Therapeutic Systems, Inc. Dispersible antibody compositions and methods for their preparation and use
US6136346A (en) * 1995-04-14 2000-10-24 Inhale Therapeutic Systems Powdered pharmaceutical formulations having improved dispersibility
JP2001507702A (ja) * 1996-12-31 2001-06-12 インヘイル・セラピューティックス・システムズ・インコーポレテッド 親水性賦形剤を有する疎水性薬剤の水性懸濁液を噴霧乾燥させる方法およびその方法によって作製された組成物
GB9814172D0 (en) 1998-06-30 1998-08-26 Andaris Ltd Formulation for inhalation
ES2289823T3 (es) 1998-08-25 2008-02-01 Advanced Inhalation Research, Inc. Formulaciones proteicas estables secadas por atomizacion.

Also Published As

Publication number Publication date
UA59358C2 (uk) 2003-09-15
JP2000503976A (ja) 2000-04-04
CZ292186B6 (cs) 2003-08-13
KR19990081886A (ko) 1999-11-15
KR100449789B1 (ko) 2005-02-03
EP0877602B1 (de) 2002-01-23
US6315983B1 (en) 2001-11-13
CA2244767C (en) 2005-11-22
CA2244767A1 (en) 1997-07-31
ES2171883T3 (es) 2002-09-16
DE59706180D1 (de) 2002-03-14
ATE212220T1 (de) 2002-02-15
PT877602E (pt) 2002-07-31
JP3725166B2 (ja) 2005-12-07
CZ233898A3 (cs) 1999-02-17
TR199801408T2 (xx) 1998-10-21
EP0877602A1 (de) 1998-11-18
WO1997026863A1 (de) 1997-07-31
DK0877602T3 (da) 2002-05-06

Similar Documents

Publication Publication Date Title
CY2366B1 (en) Process for the production of powdered pulmonary surfactant preparations.
CY1107488T1 (el) Σταθερα ξηραμενα δια ψεκασμου πρωτεϊνικα σκευασματα
AU6073296A (en) Salt-stabilized enzyme preparations
SE8702907D0 (sv) Stable pharmaceutical preparation containing granulocyte colony stimulating factor and process for producing the same
ATE230612T1 (de) Stabile pulverförmige vitamin- und carotinoid- zubereitungen und vefahren zu deren herstellung
CA2108288A1 (en) Liposomal cyclosporin formulation and process for the preparation thereof
NO865079L (no) Fremgangsmaate for fremstilling av stabiliserte humanvevplasminogenaktivatorpreparater.
AU669122B2 (en) New pyrazine derivatives, their preparation and their use
ES8704977A1 (es) Procedimiento de obtencion de un material en particulas a base de celulosa microcristalina
JPS5782311A (en) Production of liposome preparation
AU2791689A (en) Medicinal preparation comprising the association of colistin,tobramycin and amphotericin b administered by atomization
AU6756287A (en) Nicorandil-containing preparation for injection
EP0402637A3 (en) Stable freeze dried polyhematoporphyrin ether/ester composition
HUP9900954A2 (hu) Eljárás por alakú tüdőfelület-aktív készítmények előállítására
HUT41235A (en) Pesticide, particularly insecticide compositions and process for preparing benzoyl-carbamides to be applied as active ingredients thereof
MY101266A (en) Pharmaceutical formulations
ES2002723A6 (es) Un metodo para preparar indoles o derivados del indol
JPS52108088A (en) Preparation of monohydroxycarboxylic acid using microbials
JPS5290694A (en) Preparation of protoporphyrine 1x
KR880009595A (ko) 인삼정분첨가 연질캡슐 제조방법
JPS5696693A (en) Production of human standard enzyme sample from human placenta
MX9700484A (es) Leche sin lactosa y leche en polvo sin lactosa, y alimentos que los contienen y proceso para fabricarlos.
MX9702445A (es) Nuevos pirimido[1,2-]indoles.