US5789434A - Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors - Google Patents
Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors Download PDFInfo
- Publication number
- US5789434A US5789434A US08/539,409 US53940995A US5789434A US 5789434 A US5789434 A US 5789434A US 53940995 A US53940995 A US 53940995A US 5789434 A US5789434 A US 5789434A
- Authority
- US
- United States
- Prior art keywords
- carbons
- mmol
- alkyl
- aryl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 239000011159 matrix material Substances 0.000 title claims abstract description 20
- 239000002253 acid Substances 0.000 title claims description 48
- 239000003475 metalloproteinase inhibitor Substances 0.000 title description 5
- 150000001875 compounds Chemical class 0.000 claims abstract description 170
- 238000000034 method Methods 0.000 claims abstract description 126
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 81
- 125000001424 substituent group Chemical group 0.000 claims abstract description 55
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 52
- 150000003839 salts Chemical class 0.000 claims abstract description 23
- 102000005741 Metalloproteases Human genes 0.000 claims abstract description 16
- 108010006035 Metalloproteases Proteins 0.000 claims abstract description 16
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 16
- 150000001413 amino acids Chemical class 0.000 claims abstract description 6
- 239000000203 mixture Substances 0.000 claims description 164
- 125000003118 aryl group Chemical group 0.000 claims description 80
- 125000001072 heteroaryl group Chemical group 0.000 claims description 55
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 55
- -1 1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl Chemical group 0.000 claims description 54
- 125000005842 heteroatom Chemical group 0.000 claims description 33
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 29
- 230000000694 effects Effects 0.000 claims description 26
- 102000002274 Matrix Metalloproteinases Human genes 0.000 claims description 22
- 108010000684 Matrix Metalloproteinases Proteins 0.000 claims description 22
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 20
- 125000003342 alkenyl group Chemical group 0.000 claims description 17
- 150000002148 esters Chemical class 0.000 claims description 15
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims description 15
- 125000000304 alkynyl group Chemical group 0.000 claims description 14
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 14
- 229910052736 halogen Inorganic materials 0.000 claims description 13
- 206010028980 Neoplasm Diseases 0.000 claims description 12
- 229910052799 carbon Inorganic materials 0.000 claims description 11
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 10
- 230000002401 inhibitory effect Effects 0.000 claims description 10
- 150000002367 halogens Chemical class 0.000 claims description 9
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 8
- 230000001404 mediated effect Effects 0.000 claims description 8
- 201000010099 disease Diseases 0.000 claims description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
- 206010027476 Metastases Diseases 0.000 claims description 6
- 229940024606 amino acid Drugs 0.000 claims description 6
- 210000000845 cartilage Anatomy 0.000 claims description 6
- 230000009401 metastasis Effects 0.000 claims description 6
- 150000001721 carbon Chemical group 0.000 claims description 5
- 125000001188 haloalkyl group Chemical group 0.000 claims description 5
- 201000008482 osteoarthritis Diseases 0.000 claims description 5
- 230000009467 reduction Effects 0.000 claims description 5
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 5
- 206010053555 Arthritis bacterial Diseases 0.000 claims description 4
- 208000004575 Infectious Arthritis Diseases 0.000 claims description 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 4
- 201000001223 septic arthritis Diseases 0.000 claims description 4
- 208000025494 Aortic disease Diseases 0.000 claims description 3
- 208000037260 Atherosclerotic Plaque Diseases 0.000 claims description 3
- 206010011091 Coronary artery thrombosis Diseases 0.000 claims description 3
- 206010014989 Epidermolysis bullosa Diseases 0.000 claims description 3
- 208000012659 Joint disease Diseases 0.000 claims description 3
- 206010060820 Joint injury Diseases 0.000 claims description 3
- 241000124008 Mammalia Species 0.000 claims description 3
- 208000029725 Metabolic bone disease Diseases 0.000 claims description 3
- 206010064996 Ulcerative keratitis Diseases 0.000 claims description 3
- 208000002528 coronary thrombosis Diseases 0.000 claims description 3
- 230000003412 degenerative effect Effects 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 3
- 230000028709 inflammatory response Effects 0.000 claims description 3
- 210000000653 nervous system Anatomy 0.000 claims description 3
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 3
- 208000028169 periodontal disease Diseases 0.000 claims description 3
- 201000001474 proteinuria Diseases 0.000 claims description 3
- 230000000472 traumatic effect Effects 0.000 claims description 3
- 125000005018 aryl alkenyl group Chemical group 0.000 claims description 2
- 125000005015 aryl alkynyl group Chemical group 0.000 claims description 2
- 125000005843 halogen group Chemical group 0.000 claims description 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 5
- 229930182821 L-proline Natural products 0.000 claims 5
- 229960002429 proline Drugs 0.000 claims 5
- IHCCAYCGZOLTEU-UHFFFAOYSA-N 3-furoic acid Chemical compound OC(=O)C=1C=COC=1 IHCCAYCGZOLTEU-UHFFFAOYSA-N 0.000 claims 2
- JAEIBKXSIXOLOL-UHFFFAOYSA-N pyrrolidin-1-ium-3-carboxylate Chemical compound OC(=O)C1CCNC1 JAEIBKXSIXOLOL-UHFFFAOYSA-N 0.000 claims 2
- OAWXZFGKDDFTGS-UHFFFAOYSA-N pyrrolidine-1,2-dicarboxylic acid Chemical compound OC(=O)C1CCCN1C(O)=O OAWXZFGKDDFTGS-UHFFFAOYSA-N 0.000 claims 2
- LAXBNTIAOJWAOP-UHFFFAOYSA-N 2-chlorobiphenyl Chemical group ClC1=CC=CC=C1C1=CC=CC=C1 LAXBNTIAOJWAOP-UHFFFAOYSA-N 0.000 claims 1
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000005418 aryl aryl group Chemical group 0.000 claims 1
- ADPQWEGXWVSSKZ-UHFFFAOYSA-N pyrrolidine-1,3-dicarboxylic acid Chemical compound OC(=O)C1CCN(C(O)=O)C1 ADPQWEGXWVSSKZ-UHFFFAOYSA-N 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 abstract description 13
- 230000008569 process Effects 0.000 abstract description 5
- 239000008194 pharmaceutical composition Substances 0.000 abstract description 4
- 230000004962 physiological condition Effects 0.000 abstract description 2
- 101100386054 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) CYS3 gene Proteins 0.000 abstract 1
- 101150035983 str1 gene Proteins 0.000 abstract 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 468
- 239000000243 solution Substances 0.000 description 241
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical class CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 188
- 239000000047 product Substances 0.000 description 185
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 179
- 235000019439 ethyl acetate Nutrition 0.000 description 163
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 158
- 239000007787 solid Substances 0.000 description 150
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 142
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 142
- 238000006243 chemical reaction Methods 0.000 description 111
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 109
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 108
- 239000011541 reaction mixture Substances 0.000 description 106
- 238000002360 preparation method Methods 0.000 description 102
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical group CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 101
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 97
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 93
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 93
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 91
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 90
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 87
- 238000004809 thin layer chromatography Methods 0.000 description 78
- 229910052786 argon Inorganic materials 0.000 description 71
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 71
- 238000003756 stirring Methods 0.000 description 65
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 63
- 239000000543 intermediate Substances 0.000 description 58
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 56
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 51
- 239000003921 oil Substances 0.000 description 51
- 235000019198 oils Nutrition 0.000 description 51
- 239000002904 solvent Substances 0.000 description 50
- 230000002829 reductive effect Effects 0.000 description 46
- 239000012043 crude product Substances 0.000 description 45
- 238000010992 reflux Methods 0.000 description 44
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 42
- 235000019441 ethanol Nutrition 0.000 description 41
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 41
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 40
- 239000012267 brine Substances 0.000 description 40
- 239000010410 layer Substances 0.000 description 39
- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 38
- OAYLNYINCPYISS-UHFFFAOYSA-N ethyl acetate;hexane Chemical compound CCCCCC.CCOC(C)=O OAYLNYINCPYISS-UHFFFAOYSA-N 0.000 description 38
- 238000003818 flash chromatography Methods 0.000 description 38
- 229960000583 acetic acid Drugs 0.000 description 36
- 239000012044 organic layer Substances 0.000 description 35
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 34
- 229910004809 Na2 SO4 Inorganic materials 0.000 description 34
- 235000010290 biphenyl Nutrition 0.000 description 34
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical class [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 33
- 239000004305 biphenyl Substances 0.000 description 33
- 238000001914 filtration Methods 0.000 description 32
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 32
- 239000012074 organic phase Substances 0.000 description 31
- 239000000725 suspension Substances 0.000 description 31
- 238000005481 NMR spectroscopy Methods 0.000 description 30
- 238000010828 elution Methods 0.000 description 30
- 238000007429 general method Methods 0.000 description 30
- 239000000460 chlorine Substances 0.000 description 28
- 238000010626 work up procedure Methods 0.000 description 27
- 239000007858 starting material Substances 0.000 description 26
- 239000000463 material Substances 0.000 description 25
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 24
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 22
- 238000012512 characterization method Methods 0.000 description 22
- 238000000746 purification Methods 0.000 description 22
- 239000002585 base Substances 0.000 description 21
- KDLHZDBZIXYQEI-UHFFFAOYSA-N palladium Substances [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 21
- RMVRSNDYEFQCLF-UHFFFAOYSA-N thiophenol Chemical compound SC1=CC=CC=C1 RMVRSNDYEFQCLF-UHFFFAOYSA-N 0.000 description 21
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 20
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 20
- 239000013078 crystal Substances 0.000 description 20
- 238000004992 fast atom bombardment mass spectroscopy Methods 0.000 description 20
- 238000004128 high performance liquid chromatography Methods 0.000 description 19
- 239000000741 silica gel Substances 0.000 description 19
- 229910002027 silica gel Inorganic materials 0.000 description 19
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 18
- 239000008346 aqueous phase Substances 0.000 description 18
- 238000004587 chromatography analysis Methods 0.000 description 18
- 239000000284 extract Substances 0.000 description 18
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 18
- 229910000104 sodium hydride Inorganic materials 0.000 description 18
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 16
- 150000008064 anhydrides Chemical class 0.000 description 16
- 238000000605 extraction Methods 0.000 description 15
- 239000000377 silicon dioxide Substances 0.000 description 15
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 15
- 125000001309 chloro group Chemical group Cl* 0.000 description 14
- 238000001816 cooling Methods 0.000 description 14
- WGLUMOCWFMKWIL-UHFFFAOYSA-N dichloromethane;methanol Chemical compound OC.ClCCl WGLUMOCWFMKWIL-UHFFFAOYSA-N 0.000 description 14
- ZCSHNCUQKCANBX-UHFFFAOYSA-N lithium diisopropylamide Chemical compound [Li+].CC(C)[N-]C(C)C ZCSHNCUQKCANBX-UHFFFAOYSA-N 0.000 description 14
- 150000004702 methyl esters Chemical class 0.000 description 14
- 238000001953 recrystallisation Methods 0.000 description 14
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 13
- 239000012298 atmosphere Substances 0.000 description 13
- SPWVRYZQLGQKGK-UHFFFAOYSA-N dichloromethane;hexane Chemical compound ClCCl.CCCCCC SPWVRYZQLGQKGK-UHFFFAOYSA-N 0.000 description 13
- 238000001035 drying Methods 0.000 description 13
- NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 description 13
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 13
- 239000011734 sodium Substances 0.000 description 13
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 12
- 229960004132 diethyl ether Drugs 0.000 description 12
- UAOMVDZJSHZZME-UHFFFAOYSA-N diisopropylamine Chemical compound CC(C)NC(C)C UAOMVDZJSHZZME-UHFFFAOYSA-N 0.000 description 12
- 239000011780 sodium chloride Substances 0.000 description 12
- 238000010792 warming Methods 0.000 description 12
- 238000005406 washing Methods 0.000 description 12
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 11
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 description 11
- 125000004429 atom Chemical group 0.000 description 11
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- 239000012153 distilled water Substances 0.000 description 11
- 229940079593 drug Drugs 0.000 description 11
- 239000003814 drug Substances 0.000 description 11
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 10
- AYCPARAPKDAOEN-LJQANCHMSA-N N-[(1S)-2-(dimethylamino)-1-phenylethyl]-6,6-dimethyl-3-[(2-methyl-4-thieno[3,2-d]pyrimidinyl)amino]-1,4-dihydropyrrolo[3,4-c]pyrazole-5-carboxamide Chemical compound C1([C@H](NC(=O)N2C(C=3NN=C(NC=4C=5SC=CC=5N=C(C)N=4)C=3C2)(C)C)CN(C)C)=CC=CC=C1 AYCPARAPKDAOEN-LJQANCHMSA-N 0.000 description 10
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 10
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 10
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 description 10
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 description 10
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 10
- 229920001971 elastomer Polymers 0.000 description 10
- 230000007062 hydrolysis Effects 0.000 description 10
- 238000006460 hydrolysis reaction Methods 0.000 description 10
- 239000012312 sodium hydride Substances 0.000 description 10
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 10
- 238000005727 Friedel-Crafts reaction Methods 0.000 description 9
- SJRJJKPEHAURKC-UHFFFAOYSA-N N-Methylmorpholine Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 description 9
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 9
- 239000003153 chemical reaction reagent Substances 0.000 description 9
- WORJEOGGNQDSOE-UHFFFAOYSA-N chloroform;methanol Chemical compound OC.ClC(Cl)Cl WORJEOGGNQDSOE-UHFFFAOYSA-N 0.000 description 9
- 238000002425 crystallisation Methods 0.000 description 9
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- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 description 9
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 8
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 description 8
- 238000003820 Medium-pressure liquid chromatography Methods 0.000 description 8
- UOIFTOBIGNZZSO-UHFFFAOYSA-N acetic acid;ethyl acetate;hexane Chemical compound CC(O)=O.CCCCCC.CCOC(C)=O UOIFTOBIGNZZSO-UHFFFAOYSA-N 0.000 description 8
- 150000007513 acids Chemical class 0.000 description 8
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- 229910052763 palladium Inorganic materials 0.000 description 8
- 229910052708 sodium Inorganic materials 0.000 description 8
- FPGGTKZVZWFYPV-UHFFFAOYSA-M tetrabutylammonium fluoride Chemical compound [F-].CCCC[N+](CCCC)(CCCC)CCCC FPGGTKZVZWFYPV-UHFFFAOYSA-M 0.000 description 8
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical compound CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 7
- 238000005160 1H NMR spectroscopy Methods 0.000 description 7
- VKUYLANQOAKALN-UHFFFAOYSA-N 2-[benzyl-(4-methoxyphenyl)sulfonylamino]-n-hydroxy-4-methylpentanamide Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N(C(CC(C)C)C(=O)NO)CC1=CC=CC=C1 VKUYLANQOAKALN-UHFFFAOYSA-N 0.000 description 7
- FPWNLURCHDRMHC-UHFFFAOYSA-N 4-chlorobiphenyl Chemical group C1=CC(Cl)=CC=C1C1=CC=CC=C1 FPWNLURCHDRMHC-UHFFFAOYSA-N 0.000 description 7
- QMMFVYPAHWMCMS-UHFFFAOYSA-N Dimethyl sulfide Chemical compound CSC QMMFVYPAHWMCMS-UHFFFAOYSA-N 0.000 description 7
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 7
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 7
- 102100030416 Stromelysin-1 Human genes 0.000 description 7
- 101710108790 Stromelysin-1 Proteins 0.000 description 7
- 150000001299 aldehydes Chemical class 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 7
- 230000005764 inhibitory process Effects 0.000 description 7
- 230000020477 pH reduction Effects 0.000 description 7
- 239000000843 powder Substances 0.000 description 7
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- PRXNKYBFWAWBNZ-UHFFFAOYSA-N trimethylphenylammonium tribromide Chemical compound Br[Br-]Br.C[N+](C)(C)C1=CC=CC=C1 PRXNKYBFWAWBNZ-UHFFFAOYSA-N 0.000 description 1
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Images
Classifications
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
- C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
- C07C17/12—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the ring of aromatic compounds
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- C07C17/00—Preparation of halogenated hydrocarbons
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- C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
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- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
- C07C17/20—Preparation of halogenated hydrocarbons by replacement by halogens of halogen atoms by other halogen atoms
- C07C17/202—Preparation of halogenated hydrocarbons by replacement by halogens of halogen atoms by other halogen atoms two or more compounds being involved in the reaction
- C07C17/208—Preparation of halogenated hydrocarbons by replacement by halogens of halogen atoms by other halogen atoms two or more compounds being involved in the reaction the other compound being MX
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- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
- C07C205/34—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups bound to carbon atoms of six-membered aromatic rings and etherified hydroxy groups bound to acyclic carbon atoms of the carbon skeleton
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- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
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- C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
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- C07C22/04—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom having unsaturation in the rings containing six-membered aromatic rings
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- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
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- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
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- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/54—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
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- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07C25/18—Polycyclic aromatic halogenated hydrocarbons
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Definitions
- This invention relates to enzyme inhibitors, and more particularly, to novel 4-biarylbutyric or 5-biarylpentanoic acid compounds or derivatives thereof useful for inhibiting matrix metalloproteases.
- the matrix metalloproteases are a family of zinc endoproteinases which include, but are not limited to, interstitial collagenase (aka. MMP-1), stromelysin (aka. proteoglycanase, transin, or MMP-3), gelatinase A (aka. 72 kDa-gelatinase or MMP-2) and gelatinase B (aka. 95 kDa-gelatinase or MMP-9).
- MMPs interstitial collagenase
- stromelysin aka. proteoglycanase, transin, or MMP-3
- gelatinase A aka. 72 kDa-gelatinase or MMP-2
- gelatinase B aka. 95 kDa-gelatinase or MMP-9.
- TIMPs tissue Inhibitor of MetalloProteinase
- MMPs are capable of destroying a variety of connective tissue components of articular cartilage or basement membranes. Each MMP is secreted as an inactive proenzyme which must be cleaved in a subsequent step before it is able to exert its own proteolytic activity.
- MMP-3 have been implemented as the in vivo activator for other MMPs such as MMP-1 and MMP-9 (A. Ho, H. Nagase, Arch Biochem Biophys., 267, 211-16 (1988); Y. Ogata, J. J. Enghild, H. Nagase, J. Biol. Chem., 267, 3581-84 (1992)).
- MMP-3 inhibitors should limit the activity of other MMPs that are not directly inhibited by such inhibitors.
- MMP-3 can cleave and thereby inactivate the endogenous inhibitors of other proteinases such as elastase (P. G. Winyard, Z. Zhang, K. Chidwick, D. R. Blake, R. W. Carrell G., Murphy, FEBS Letts., 279, 1, 91-94 (1991)). Inhibitors of MMP-3 could thus influence the activity of other destructive proteinases by modifying the level of their endogenous inhibitors.
- elastase P. G. Winyard, Z. Zhang, K. Chidwick, D. R. Blake, R. W. Carrell G., Murphy, FEBS Letts., 279, 1, 91-94 (1991)
- a number of diseases are thought to be mediated by excess or undesired matrix-destroying metalloprotease activity or by an imbalance in the ratio of the MMPs to the TIMPs. These include: a) osteoarthritis (Woessner, et al., J. Biochelogical Chem., 259(6), 3633-3638 (1984); J. Rheumatol., 10, 852-860 (1883)), b) rheumatoid arthritis (D. E. Mullins, et al., Biochim. Biophys.
- OA oeteoarthritis
- RA rheumatoid arthritis
- septic arthritis the progressive loss of articular cartilage and thereby normal joint function.
- No marketed pharmaceutical agent is able to prevent or slow this cartilage loss, although nonsteroidal antiinflammatory drugs (NSAIDs) have been given to control pain and swelling.
- NSAIDs nonsteroidal antiinflammatory drugs
- MMP inhibitors are expected to halt or reverse the progression of cartilage loss and obviate or delay surgical intervention.
- Proteases are critical elements at several stages in the progression of metastatic cancer.
- the proteolytic degradation of structural protein in the basal membrane allows for expansion of a tumor in the primary site, evasion from this site as well as homing and invasion in distant, secondary sites.
- tumor induced angiogenesis is required for tumor growth and is dependent on proteolytic tissue remodeling.
- Transfection experiment with various types of proteases have shown that the matrix metalloproteases play a dominant role in these processes in particular gelatinases A and B (MMP-2 and MMP-9, respectively).
- gelatinases A and B MMP-2 and MMP-9, respectively.
- TIMP-2 a protein
- TIMP-2 a protein
- TIMP-2 inhibits tumor-induced angiogenesis in experimental systems
- the synthetic matrix metalloprotease inhibitor batimastat when given intraperitoneally inhibits human colon tumor growth and spread in an orthotopic model in nude mice (Cancer Res. 54, 4726-4728, 1994) and prolongs the survival of mice bearing human ovarian carcinoma xenografts (Cancer Res. 53, 2087-2091, 1993).
- the use of this and related compounds has been described in WO-A-9321942.
- the preferred compounds of these patents have peptide backbones with a zinc complexing group (hydroxamic acid, thiol, carboxylic acid or phosphinic acid) at one end and a variety of sidechains, both those found in the natural amino acids as well as those with more novel functional groups.
- a zinc complexing group hydroxamic acid, thiol, carboxylic acid or phosphinic acid
- Such small peptides are often poorly absorbed, exhibiting low oral bioavailability. They are also subject to rapid proteolytic metabolism, thus having short half lives.
- batimastat the compound described in WO-A-9321942, can only be given intraperitoneally.
- 3-biphenoylpropanoic and 4-biaryloylbutanoic acids are described in the literature as anti-inflammatory, anti-platelet aggregation, anti-phlogistic, anti-proliferative, hypolipidemic, antirheumatic, analgesic, and hypocholesterolemic agents. In none of these examples is a reference made to MMP inhibition as a mechanism for the claimed therapeutic effect. Certain related compounds are also used as intermediates in the preparation of liquid crystals.
- German Patent Application No. 19 57 750 of Tomae also describes certain of the above methylene substituted biphenoylpropanoic acids.
- German Patent No. 28 54 475 uses the following compound as an intermediate.
- the biphenyl group is not substituted. ##STR10##
- MMP inhibitors which possess improved bioavailablity and biological stability relative to the peptide-based compounds of the prior art, and which can be optimized for use against particular target MMPs. Such compounds are the subject of the present application.
- This invention relates to compounds having matrix metalloprotease inhibitory activity and the generalized formula:
- (T) x A represents a substituted or unsubstituted aromatic 6-membered ring or heteroaromatic 5-6 membered ring containing 1-2 atoms of N, O, or S.
- T represents one or more substituent groups, the subscript x represents the number of such substituent groups, and A represents the aromatic or heteroaromatic ring, designated as the A ring or A unit.
- N is employed in conjunction with either S or O in the A ring, these heteroatoms are separated by at least one carbon atom.
- the substituent group(s) T are independently selected from the group consisting of halogen; alkyl; haloalkyl; alkenyl; alkynyl; --(CH 2 ) p Q in which p is 0 or an integer of 1-4; and -alkenyl-Q in which the alkenyl moiety comprises 2-4 carbons.
- Q in the latter two groups is selected from the group consisting of aryl, heteroaryl, --CN, --CHO, --NO 2 , --CO 2 R 2 , --OCOR 2 , --SOR 3 , --SO 2 R 3 , --CON(R 2 ) 2 , --SO 2 N(R 2 ) 2 , --COR 2 , --N(R 2 ) 2 , --N(R 2 )COR 2 , --N(R 2 )CO 2 R 3 , --N(R 2 )CON(R 2 ) 2 , --CHN 4 , --OR 4 , and --SR 4 .
- R 2 represents H, alkyl, aryl, heteroaryl, arylalkyl, or heteroaryl-alkyl
- R3 represents alkyl, aryl, heteroaryl, arylalkyl, or heteroaryl-alkyl
- R4 represents H, alkyl, aryl, heteroaryl, arylalkyl, heteroaryl-alkyl, alkenyl, alkynyl, haloalkyl, acyl, or alkyleneoxy or polyalkyleneoxy terminated with H, alkyl, or phenyl.
- Unsaturation in a moiety which is attached to Q or which is part of Q is separated from any N, O, or S of Q by at least one carbon atom.
- the A ring may be unsubstituted or may carry up to 2 substituents T. Accordingly, the subscript x is 0, 1, or 2.
- B represents an aromatic 6-membered ring or a heteroaromatic 5-6 membered ring containing 1-2 atoms of N, O, or S. It is referred to as the B ring or B unit.
- N is employed in conjunction with either S or O in the B ring, these heteroatoms are separated by at least one carbon atom.
- E represents a chain of n carbon atoms bearing m substituents R 6 , in which the R 6 groups are independent substituents, or constitute spiro or nonspiro rings. Rings may be formed in two ways: a) two groups R 6 are joined, and taken together with the chain atom(s) to which the two R6 group(s) are attached, and any intervening chain atoms, constitute a 3-7 membered ring, or b) one group R 6 is joined to the chain on which this one group R 6 resides, and taken together with the chain atom(s) to which the R 6 group is attached, and any intervening chain atoms, constitutes a 3-7 membered ring.
- the number n of carbon atoms in the chain is 2 or 3
- the number m of R 6 substituents is an integer of 1-3.
- the number of carbons in the totality of R 6 groups is at least two.
- Each group R 6 is independently selected from the group consisting of:
- alkyl provided that if the A unit is phenyl, the B unit is phenylene, m is 1, and n is 2, then x is 1 or 2;
- aryl provided that if said A unit is phenyl, said B unit is phenylene, said aryl group is phenyl, n is 2, and m is 1 or 2, then x is 1 or 2;
- R 7 is selected from the group consisting of:
- nonaromatic substituted or unsubstituted heterocycles containing and connected through a N atom, and comprising one additional O or S;
- aryl portion of an aryl-containing R 7 group comprises 4-9 carbons and at least one N, O, or S heteroatom, but
- R 8 is selected from the group consisting of: alkyl
- R 9 represents alkyl of at least two carbons, aryl, heteroaryl, arylalkyl, or heteroaryl-alkyl;
- R 8 is --C(O)R 9 , Z is S or O;
- R 8 may also be alkyleneoxy or polyalkyleneoxy terminated with H, alkyl, or phenyl;
- aryl or heteroaryl portions of any of the T or R 6 groups optionally may bear up to two substituents selected from the group consisting of --(CH 2 ) y C(R 11 )(R 12 )OH, --(CH 2 ) y OR 11 , --(CH 2 ) y SR 11 , --(CH 2 ) y S(O)R 11 , --(CH 2 ) y S(O) 2 R 11 , --(CH 2 ) y SO 2 N(R 11 ) 2 , --(CH 2 ) y N(R 11 ) 2 , --(CH 2 ) y N(R 11 )COR 12 , --OC(R 11 ) 2 O-- in which both oxygen atoms are connected to the aryl ring, --(CH 2 ) y COR 11 , --(CH 2 ) y CON(R 11 ) 2 , --(CH 2 ) y CO 2 R 11 , --(CH 2 ) y OCOR 11
- G represents --PO 3 H 2 , --M, ##STR14## in which M represents --CO 2 H, --CON(R 11 ) 2 , or --CO 2 R 12 , and R 13 represents any of the side chains of the 19 noncyclic naturally occurring amino acids.
- Pharmaceutically acceptable salts of these compounds are also within the scope of the invention.
- the biphenyl portion of the molecule is unsubstituted, and the propanoic or butanoic acid portion is either unsubstituted or has a single methyl or phenyl group.
- Presence of the larger phenyl group has been reported to cause prior art compounds to be inactive as anti-inflammatory analgesic agents. See, for example, R. G. Child, et al., J. Pharm. Sci., 66, 466-476 (1977)
- compounds which exhibit potent MMP inhibitory activity contain a substituent of significant size on the propanoic or butanoic portion of the molecule.
- the biphenyl portions of the best MMP inhibitors also preferably contain a substituent on the 4' position, although when the propanoic or butanoic portions are optimally substituted, the unsubstituted biphenyl compounds of the invention have sufficient activity to be considered realistic drug candidates.
- compositions having matrix metalloprotease inhibitory activity which compositions comprise a compound of the invention as described above and in more detail in the detailed description below, and a pharmaceutically acceptable carrier.
- the invention also relates to a method of treating a human to achieve an effect, in which the effect is: alleviation of osteoarthritis, rheumatoid arthritis, septic arthritis, periodontal disease, corneal ulceration, proteinuria, aneurysmal aortic disease, dystrophobic epidermolysis bullosa, conditions leading to inflammatory responses, osteopenias mediated by MMP activity, tempero mandibular joint disease, or demyelating diseases of the nervous system; retardation of tumor metastasis or degenerative cartilage loss following traumatic joint injury; reduction of coronary thrombosis from atherosclerotic plaque rupture; or improved birth control; the method comprising administering an amount of a compound of the invention as described above, and in more detail in the detailed description below, which is effective to inhibit the activity of at least one matrix metalloprotease, resulting in achievement of the desired effect.
- FIG. 1 is a graph which shows the inhibition of B16.F10 experimental metastasis in male BDF1 mice by invention compounds at 40 mg/kg (po);
- FIG. 2 is a graph which shows the inhibition of B16.F10 spontaneous metastasis in male BDF1 mice by invention compounds at 10 mg/kg (po);
- FIG. 3 is a graph which shows the inhibition of SKOV-3 ascites in female Balb/c nu/nu mice by invention compounds at 40 mg/kg (po).
- the compounds of the present invention are materials having matrix metalloprotease inhibitory activity and the generalized formula:
- (T) x A represents a substituted or unsubstituted aromatic or heteroaromatic moiety selected from the group consisting of: ##STR15## in which R 1 represents H or alkyl of 1-3 carbons.
- each T represents a substituent group, referred to as a T group or T unit.
- Substituent groups T are independently selected from the group consisting of: the halogens --F, --Cl, --Br, and --I; alkyl of 1-10 carbons; haloalkyl of 1-10 carbons; alkenyl of 2-10 carbons; alkynyl of 2-10 carbons; --(CH 2 ) p Q in which p is 0 or an integer 1-4, and -alkenyl-Q in which the alkenyl moiety comprises 2-4 carbons.
- Q in each of the latter two groups is selected from the group consisting of aryl of 6-10 carbons; heteroaryl comprising 4-9 carbons and at least one N, O, or S heteroatom; --CN; --CHO; --NO 2 ; --CO 2 R 2 ; --OCOR 2 ; --SOR 3 ; --SO 2 R 3 ; --CON(R 2 ) 2 ; --SO 2 N(R 2 ) 2 ; --C(O)R 2 ; --N(R 2 ) 2 ; --N(R 2 )COR 2 ; --N(R 2 )CO 2 R 3 ; --N(R 2 )CON(R 2 ) 2 ; --CHN 4 ; --OR 4 ; and --SR 4 .
- the groups R 2 , R 3 , and R 4 are defined as follows.
- R 2 represents H; alkyl of 1-6 carbons; aryl of 6-10 carbons; heteroaryl comprising 4-9 carbons and at least one N, O, or S heteroatom; arylalkyl in which the aryl portion contains 6-10 carbons and the alkyl portion contains 1-4 carbons; or heteroaryl-alkyl in which the heteroaryl portion comprises 4-9 carbons and at least one N, O, or S heteroatom and the alkyl portion contains 1-4 carbons.
- R 3 represents alkyl of 1-4 carbons; aryl of 6-10 carbons; heteroaryl comprising 4-9 carbons and at least one N, O, or S heteroatom; arylalkyl in which the aryl portion contains 6-10 carbons and the alkyl portion contains 1-4 carbons; or heteroaryl-alkyl in which the heteroaryl portion comprises 4-9 carbons and at least one N, O, or S heteroatom and the alkyl portion contains 1-4 carbons.
- R 4 represents H; alkyl of 1-12 carbons; aryl of 6-10 carbons; heteroaryl comprising 4-9 carbons and at least one N, O, or S heteroatom; arylalkyl in which the aryl portion contains 6-10 carbons and the alkyl portion contains 1-4 carbons; heteroaryl-alkyl in which the heteroaryl portion comprises 4-9 carbons and at least one N, O, or S heteroatom and the alkyl portion contains 1-4 carbons; alkenyl of 2-12 carbons; alkynyl of 2-12 carbons; --(C q H 2q O) r R 5 in which q is 1-3, r is 1-3, and R 5 is H provided q is greater than 1, or R 5 is alkyl of 1-4 carbons, or phenyl; --(CH 2 ) s X in which s is 2-3 and X is halogen; or --C(O)R 2 .
- Any unsaturation in a moiety which is attached to Q or which is part of Q is separated from any N, O, or S of Q by at least one carbon atom, and the number of substituents, designated x, is 0, 1, or 2.
- B represents an aromatic or heteroaromatic ring selected from the group consisting of: ##STR16## in which R 1 is defined as above. These rings are referred to as the B ring or B unit.
- D represents the moieties ##STR17##
- E represents a chain of n carbon atoms bearing m substituents R 6 , referred to as R 6 groups or R 6 units.
- the R 6 groups are independent substituents, or constitute spiro or nonspiro rings. Rings may be formed in two ways: a) two groups R 6 are joined, and taken together with the chain atom(s) to which the two R6 group(s) are attached, and any intervening chain atoms, constitute a 3-7 membered ring, or b) one group R 6 is joined to the chain on which this one group R 6 resides, and taken together with the chain atom(s) to which the R 6 group is attached, and any intervening chain atoms, constitutes a 3-7 membered ring.
- the number n of carbon atoms in the chain is 2 or 3
- the number m of R 6 substituents is an integer of 1-3.
- the number of carbons in the totality of R 6 groups is at least two.
- Each group R 6 is independently selected from the group consisting of the substituents listed below as items 1)-14).
- An R 6 group may be alkyl of 1-10 carbons, provided that if the A unit is phenyl, the B unit is phenylene, m is 1, n is 2, and the alkyl group is located on the alpha carbon relative to the D unit, then x is 1 or 2.
- An R 6 group may be aryl of 6-10 carbons, provided that if the A unit is phenyl, the B unit is phenylene, the aryl group is phenyl, n is 2, and m is 1 or 2, then x is 1 or 2.
- An R 6 group may be heteroaryl comprising 4-9 carbons and at least one N, O, or S heteroatom.
- An R 6 group may be arylalkyl in which the aryl portion contains 6-10 carbons and the alkyl portion contains 1-8 carbons.
- An R 6 group may be heteroaryl-alkyl in which the heteroaryl portion comprises 4-9 carbons and at least one N, O, or S heteroatom, and the alkyl portion contains 1-8 carbons;
- An R 6 group may be alkenyl of 2-10 carbons.
- An R 6 group may be aryl-alkenyl in which the aryl portion contains 6-10 carbons and the alkenyl portion contains 2-5 carbons.
- An R 6 group may be heteroaryl-alkenyl in which the heteroaryl portion comprises 4-9 carbons and at least one N, O, or S heteroatom and the alkenyl portion contains 2-5 carbons;
- An R 6 group may be alkynyl of 2-10 carbons.
- An R 6 group may be aryl-alkynyl in which the aryl portion contains 6-10 carbons and the alkynyl portion contains 2-5 carbons.
- An R 6 group may be heteroaryl-alkynyl in which the heteroaryl portion comprises 4-9 carbons and at least one N, O, or S heteroatom and the alkynyl portion contains 2-5 carbons.
- R 6 group may be --(CH 2 ) t R 7 in which t is 0 or an integer of 1-5 and R 7 is selected from the group consisting of ##STR18## as well as corresponding heteroaryl moieties in which the aryl portion of an aryl-containing R 7 group comprises 4-9 carbons and at least one N, O, or S heteroatom.
- R 7 groups Y represents O or S; R 1 , R 2 , and R 3 are as defined above; and u is 0, 1, or 2; provided that when R 7 is ##STR19## and the A unit is phenyl, the B unit is phenylene, m is 1, n is 2, and t is 0, then x is 1 or 2.
- R 6 group may be --(CH 2 ) v ZR 8 in which v is 0 or an integer of 1 to 4; Z represents --S--, --S(O)--, --SO 2 --, or --O--; and R 8 is selected from the group consisting of: alkyl of 1 to 12 carbons; aryl of 6 to 10 carbons; heteroaryl comprising 4-9 carbons and at least one N, O, or S heteroatom; arylalkyl in which the aryl portion contains 6 to 12 carbons and the alkyl portion contains 1 to 4 carbons; heteroarylalkyl in which the aryl portion comprises 4-9 carbons and at least one N, O, or S heteroatom and the alkyl portion contains 1-4 carbons; --C(O)R 9 in which R 9 represents alkyl of 2-6 carbons, aryl of 6-10 carbons, heteroaryl comprising 4-9 carbons and at least one N, O, or S heteroatom, or arylalkyl in which the aryl portion contains
- R 8 is --C(O)R 9 , Z is --S-- or --O--;
- R 8 when Z is --O--, R 8 may also be --(C q H 2q O) r R 5 in which q, r, and R 5 are as defined above;
- R 6 group may be --(CH 2 ) w SiR 10 3 in which w is an integer of 1 to 3, and R 10 represents alkyl of 1 to 2 carbons.
- aryl or heteroaryl portions of any of the T or R 6 groups optionally may bear up to two substituents selected from the group consisting of --(CH 2 ) y C(R 11 )(R 12 )OH, --(CH 2 ) y OR 11 , --(CH 2 ) y SR 11 , --(CH 2 ) y S(O)R 11 , --(CH 2 ) y S(O) 2 R 11 , --(CH 2 ) y SO 2 N(R 11 ) 2 , --(CH 2 ) y N(R 11 ) 2 , --(CH 2 ) y N(R 11 )COR 12 , --OC(R 11 ) 2 O-- in which both oxygen atoms are connected to the aryl ring, --(CH 2 ) y COR 11 , --(CH 2 ) y CON(R 11 ) 2 , --(CH 2 ) y CO 2 R 11 , --(CH 2 ) y OCOR 11
- G represents --PO 3 H 2 , --M, ##STR20## in which M represents --CO 2 H, --CON(R 11 ) 2 , or --CO 2 R 12 , and R 13 represents any of the side chains of the 19 noncyclic naturally occurring amino acids.
- Pharmaceutically acceptable salts of the compounds falling within the generalized formula (I) are also within the invention.
- the substituent group T is preferably halogen, or an ether OR 4 wherein R 4 is preferably alkyl of 1-12 carbons or arylalkyl in which the aryl portion is 6-10 carbons and the alkyl portion contains 1-4 carbons. Most preferably, T is halogen, and when T is OR 4 , R 4 is alkyl of 1-6 carbons, or benzyl.
- the subscript x which defines the number of T substituents, is preferably 1 or 2, most preferably 1, and this substituent is on the 4-position of ring A.
- the A ring is preferably a phenyl or thiophene ring, most preferably phenyl.
- the B ring is preferably a 1,4-phenylene or 2,5-thiophene ring, most preferably 1,4-phenylene.
- the D unit is most preferably a carbonyl group.
- the group R6 is preferably:
- arylalkyl wherein the aryl portion contains 6-10 carbons and the alkyl portion contains 1-8 carbons;
- v is 0 or an integer of 1-4, Z is S or O, and R 8 is aryl of 6-10 carbons or arylalkyl wherein the aryl portion contains 6 to 12 carbons and the alkyl portion contains 1 to 4 carbons.
- the group R6 is most preferably the following, and in these, any aromatic moiety is preferably substituted:
- R 7 is N-phthalimidoyl, N-(1,2-naphthalenedicarboximidoyl), N-(2,3-naphthalenedicarboximidoyl), or N-(1,8-naphthalenedicarboximidoyl); or
- the G unit is most preferably a carboxylic acid group.
- alkyl means straight, branched, cyclic, and polycyclic materials.
- haloalkyl means partially or fully halogenated alkyl groups such as --(CH 2 ) 2 Cl, --CF 3 and --C 6 F 13 , for example.
- the B ring of generalized formula (I) is a substituted or unsubstituted aromatic or heteroaromatic ring, in which any substituents are groups which do not cause the molecule to fail to fit the active site of the target enzyme, or disrupt the relative conformations of the A and B rings, such that they would be detrimental.
- groups may be moieties such as lower alkyl, lower alkoxy, CN, NO 2 , halogen, etc., but are not to be limited to such groups.
- the invention relates to compounds of generalized formula (I) in which at least one of the units A, B, T, and R 6 comprises a heteroaromatic ring.
- Preferred heteroaromatic ring-containing compounds are those in which the heteroaryl groups are heteroaryl of 4-9 carbons comprising a 5-6 membered heteroaromatic ring containing O, S, or NR 1 when the ring is 5-membered, and N when said ring is 6-membered.
- Particularly preferred heteroaromatic ring-containing compounds are those in which at least one of the A and B units comprises a thiophene ring.
- a unit is thiophene, it is preferably connected to B unit at position 2 and carries one substituent group T on position 5.
- B Unit is thiophene, it is preferably connected through positions 2 and 5 to D and A units respectively.
- the A and B rings are preferably phenyl and phenylene, respectively, the A ring preferably bears at least one substituent group T preferably located on the position furthest from the position of the A ring which is connected to the B ring, the D unit is preferably a carbonyl group, and the G unit is preferably a carboxyl group.
- the invention relates to compounds of generalized formula (I), in the E unit of which n is 2 and m is 1. These compounds thus possess two carbon atoms between the D unit and the G unit, and carry one substituent on this two-carbon chain.
- the invention relates to compounds of generalized formula (I) in which the A ring is a substituted or unsubstituted phenyl group, the B ring is p-phenylene, and aryl portions of any aryl-containing T and R 6 moieties contain only carbon in the rings. These compounds thus contain no heteroaromatic rings.
- the invention relates to compounds of generalized formula (I) in which m is 1 and R 6 is an independent substituent.
- These compounds are materials which contain only a single substituent R 6 on the E unit, and this substituent in not involved in a ring.
- Preferred compounds within this subset have the formula ##STR21## in which x is 1 or 2, and one substituent group T is located on the 4-position of the A ring, relative to the point of attachment between the A and B rings.
- Substituent group T of this subset is preferably the halogens --Cl, --Br or I or is an ether --OR 4 .
- Most preferred compounds contain only one substituent T on the 4-position of the A ring relative to the attachment to B ring.
- the invention relates to compounds of generalized formula (I) in which the number of substituents m on the E unit is 2 or 3; and when m is 2, both groups R 6 are independent substituents, or together constitute a spiro ring, or one group R 6 is an independent substituent and the other constitutes a spiro ring; and when m is 3, two groups R 6 are independent substituents and one group R 6 constitutes a ring, or two groups R6 constitute a ring and one group R6 is an independent substituent, or three groups R6 are independent substituents.
- This subset therefore contains compounds in which the E unit is di- or tri-substituted, and in the disubstituted case any rings formed by one or both R 6 groups are spiro rings, and in the trisubstituted case, the R 6 groups may form either spiro or nonspiro rings.
- the invention relates to compounds of generalized formula (I) in which the number of substituents m on the E unit is 1 or 2; and when m is 1, the group R 6 constitutes a nonspiro ring; and when m is 2, both groups R 6 together constitute a nonspiro ring or one group R6 is an independent substituent and the other constitutes a nonspiro ring.
- This subset therefore contains compounds in which the E unit carries one or two substituents R 6 , and at least one of these substituents is involved in a nonspiro ring.
- representative compounds of generalized formula (I) in which one or more of the substituent groups R 6 are involved in formation of nonspiro rings have E units of the following structures: ##STR22## in which a is 0, 1, or 2; b is 0 or 1; c is 0 or 1; d is 0 or 1; c+d is 0 or 1; e is 1-5; f is 1-4; g is 3-5; h is 2-4; i is 0-4; j is 0-3; k is 0-2; the total number of groups R 6 is 0, 1, or 2; U represents O, S, or NR 1 ; and z is 1 or 2; Each group R 14 is independently selected from the group consisting of: alkyl of 1-9 carbons; arylalkyl in which the alkyl portion contains 1-7 carbons and the aryl portion contains 6-10 carbons; alkenyl of 2-9 carbons; aryl-substituted alkenyl in which the alkenyl portion contains
- Preferred compounds of generalized formula (I) in which one or more of the substituent groups R 6 are involved in formation of nonspiro rings have E units of the following structures: ##STR23## in which a, b, c, d, (c+d), e, g, i, k, the total number of groups R 6 , U, and R 14 are as defined above.
- the invention also relates to certain intermediates useful in the synthesis of some of the claimed inhibitors.
- These intermediates are compounds having the generalized formula ##STR25## in which E represents ##STR26## T represents a substituent group, and x is 1 or 2.
- the compounds of the invention may be prepared by use of known chemical reactions and procedures. Nevertheless, the following general preparative methods are presented to aid the reader in synthesizing the inhibitors, with more detailed particular examples being presented below in the experimental section describing the working examples.
- variable groups of these methods are as described in the generic description if they are not specifically defined below.
- the variable subscript n is independently defined for each method.
- R 6 or T a variable group with a given symbol
- each of these groups may be independently varied within the range of definitions for that symbol.
- the compounds of the invention contain as the E unit a chain of 2 or 3 carbon atoms bearing 1 to 3 substituents R 6 which are not defined as H.
- R 6 groups are used as if their definition includes H, to show where such R 6 groups may exist in the structures, and for ease in drawing.
- R 6 may be H in addition to the moieties set forth in the definition of R 6 .
- the ultimate compounds contain 1 to 3 non-hydrogen groups R 6 .
- the raw product I-A often exists as a mixture of isomers via attack of the anhydride from either of the two carbonyls.
- the resultant isomers can be separated into pure forms by crystallization or chromatography using standard methods known to those skilled in the art.
- the succinic anhydrides III can be prepared via a Stobbe Condensation of a dialkyl succinate with an aldehyde or ketone (resulting in side chain R 6 ), followed by catalytic hydrogenation, hydrolysis of a hemiester intermediate to a diacid and then conversion to the anhydride III by reaction with acetyl chloride or acetic anhydride.
- the hemiester intermediate is converted by treatment with thionyl chloride or oxalyl chloride to the acid chloride IV.
- Stobbe condensation including lists of suitable solvents and bases see W. S. Johnson and G. H. Daub, Org. React., 6, 1 (1951).
- Method A is especially useful for the preparation of cyclic compounds such as I-A-3 in which two R 6 groups are connected in a methylene chain to form a 3-7 member ring.
- Small ring (3-5 member) anhydrides are readily available only as cis isomers which yield cis invention compounds I-A-3.
- the trans compounds I-A-4 are then prepared by treatment of I-A-3 with a base such as DBU in THF.
- the substituted four member ring starting material anhydrides such as III-A-1 are formed in a photochemical 2+2 reaction as shown below. This method is especially useful for the preparation of compounds in which R 14 is acetoxy or acetoxymethylene. After the subsequent Friedel-Crafts reaction the acetate can be removed by basic hydrolysis and the carboxyl protected by conversion to 2-(trimethylsilyl)ethyl ester. The resultant intermediate with R 14 ⁇ CH 2 OH can be converted to invention compounds with other R 14 groups by using procedures described in General Method K. ##STR28##
- the Friedel Crafts method is also useful when double bonds are found either between C-2 and C-3 of a succinoyl chain (from maleic anhydride or 1-cyclopentene-1,2-dicarboxylic anhydride, for example) or when a double bond is found in a side chain, such as in the use of itaconic anhydride as starting material to yield products in which two R 6 groups as found on one chain carbon together form an exo-methylene ( ⁇ CH 2 ) group. Subsequent uses of these compounds are described in Methods D and E.
- the compounds I can be prepared via a reaction sequence involving mono-alkylation of a dialkyl malonate VI with an alkyl halide to form intermediate VII, followed by alkylation with a halomethyl biphenyl ketone VIII to yield intermediate IX.
- Compounds of structure IX are then hydrolyzed with aqueous base and then heated to decarboxylate the malonic acid intermediate and yield I-B-2 (Method B-1).
- aqueous base the esters I-B-2 with R 12 as alkyl are obtained, and using more than two equivalents of base the acid compounds (R 12 ⁇ H) are obtained.
- the diester intermediate IX can be heated with a strong acid such as concentrated hydrochloric acid in acetic acid in a sealed tube at about 110 ° C. for about 24 hr to yield I-B-2 (R 12 ⁇ H).
- a strong acid such as concentrated hydrochloric acid in acetic acid in a sealed tube at about 110 ° C. for about 24 hr to yield I-B-2 (R 12 ⁇ H).
- reaction of VI with VIII can be conducted before that with the alkyl halide to yield the same IX (Method B-2).
- Intermediates VIII are formed from biphenyls II in a Friedel-Craft reaction with haloacetyl halides such as bromoacetyl bromide or chloroacetyl chloride.
- the biphenyl can be reacted with acetyl chloride or acetic anhydride and the resultant product halogenated with, for example, bromine to yield intermediates VIII (X ⁇ Br).
- Method B has the advantage of yielding single regio isomers when Method A yields mixtures.
- Method B is especially useful when the side chains R 6 contain aromatic or heteroaromatic rings that may participate in intramolecular acylation reactions to give side products if Method A were to be used.
- This method is also very useful when the R 6 group adjacent to the carboxyl of the final compound contains heteroatoms such as oxygen, sulfur, or nitrogen, or more complex functions such as imide rings.
- Acid halide X is reacted with the lithium salt of chiral auxiliary XI (R is often isopropyl or benzyl) to yield intermediate XII, which in turn is akylated at low temperatures (typically under -50° C.) with halo-tert-butylacetyl compound XIII to yield pure isomer XIV.
- the use of opposite chirality XI yields opposite chirality XIV.
- Conversion of XIV to the enantiomerically pure diacid XV is accomplished by treatment with lithium hydroxide/hydrogen peroxide in THF/water, followed by acids such as trifluoroacetic acid.
- the compound XV is then converted to enantiomerically pure anhydride III-A by treatment with acetyl chloride.
- the use of a Friedel-Crafts reaction as in method A then converts III-A to I-C-1.
- Biphenyl starting material II may also first be reacted in a Friedel-Crafts reaction as earlier described with succinic anhydride followed by Fisher esterification with a lower alcohol such as methanol in the presence of a strong acid such as sulfuric acid to form acyl derivative I-C-2.
- the carbonyl group of this material is then blocked as a ketal such as that formed by treatment with 1,2-bistrimethyl-silyloxyethane in the presence of a catalyst such as trimethyl-silyltriflate in a suitable solvent.
- a catalyst such as trimethyl-silyltriflate
- General Method F--Biaryl compounds such as those of this application may also be prepared by Suzuki or Stille cross-coupling reactions of aryl or heteroaryl metallic compounds in which the metal is zinc, tin, magnesium, lithium, boron, silicon, copper, cadmium or the like with an aryl or heteroaryl halide or triflate (trifluoromethane-sulfonate) or the like.
- Met or X is the metal and the other is the halide or triflate.
- Pd(com) is a soluble complex of palladium such as tetrakis(triphenylphosphine)-palladium(0) or bis-(triphenylphos-phine)-palladium(II) chloride.
- the materials in which X is halo can be converted to those in which X is metal by reactions well known to those skilled in the art such as treatment of a bromo intermediate with hexamethylditin and palladium tetrakistriphenylphosphine in toluene at reflux to yield the trimethyltin intermediate.
- the intermediates XXII are either commercial or easily prepared from commercial materials by methods well known to those skilled in the art.
- Method F is also especially useful for the preparation of products in which the aryl groups A or B contain one or more heteroatoms (heteroaryls) such as those compounds that contain thiophene, furan, pyridine, pyrrole, oxazole, thiazole, pyrimidine or pyrazine rings or the like instead of phenyls.
- heteroaryls such as those compounds that contain thiophene, furan, pyridine, pyrrole, oxazole, thiazole, pyrimidine or pyrazine rings or the like instead of phenyls.
- This material is then reduced to the alcohol with a reducing agent capable of selective reduction of the ketone such as sodium borohydride, followed by dehydration with triphenylphosphine/diethyl azodicarboxylate (DEAD) in a suitable solvent such as THF at reflux to yield XXIX.
- a reducing agent capable of selective reduction of the ketone such as sodium borohydride
- DEAD triphenylphosphine/diethyl azodicarboxylate
- THF triphenylphosphine/diethyl azodicarboxylate
- Hydrolysis of the ester with aqueous base followed by amide formation with R 12 ONHR 12 (R is lower alkyl, but usually CH 3 ) in the presence of a coupling agent such as dicyclohexyldiimide (DCC) yields XXX.
- R 12 ONHR 12 R is lower alkyl, but usually CH 3
- DCC dicyclohexyldi
- the carbobenzyloxy group is removed by reaction with hydrogen and a catalyst such as palladium on carbon to yield the unsubstituted invention compound 1-I-2 optionally followed by N-alkylation to yield compound 1-I-3.
- a catalyst such as palladium on carbon
- the intermediate XXXX can be directly treated with ozone followed by the other steps of this method to yield 1-I-3 in which R 14 is optionally substituted benzyl rather than as in 1-I-1.
- This malonate can be further alkylated under conditions familiar to those skilled in the art to yield L which in turn is treated with acid and then heated to yield invention compound 1-J-1.
- the final alkylation can be omitted to yield products in which the R6 adjacent to the carboxyl is H.
- XXXXVII can be alkylated with 3-halopropionate ester LI in the presence of base such as LDA to yield ester 1-J-2 which can then be hydrolyzed with aqueous base to yield invention compound 1-J-3 upon treatment with acid. This method is especially useful if any of the groups R 6 contain aromatic residues.
- Method K--The compounds of this invention in which two R 6 groups are joined to form a substituted 5-member ring are most conveniently prepared by method K.
- acid LII (R ⁇ H) is prepared using the protocols described in Tetrahedron, Vol. 37, Suppl., 1981, 411.
- Substituted bromobiphenyl LIII is converted to its Grignard reagent by treatment with magnesium which is then reacted with LII to yield alcohol LIV.
- Alcohol LIV is eliminated via base treatment of its mesylate by using conditions well known to those skilled in the art to yield olefin LV.
- LIII is converted to a trimethyltin intermediate via initial metallation of the bromide with n-butyllithium at low temperature (-78°) followed by treatment with chlorotrimethyltin and LII is converted to an enoltriflate by reaction with 2- N,N-bis(trifluoromethylsulfonyl)amino!-5-chloropyridine in the presence of a strong aprotic base.
- the tin and enoltriflate intermediates are then coupled in the presence of a Pd O catalyst, CuI and AsPh 3 to yield directly intermediate LV.
- Ozonolysis of LV (workup with methylsulfide) yields aldehyde LVI.
- treatment with OsO 4 followed by HIO 4 converts LV to LVI.
- a leaving group such as tosylate (X ⁇ OTs) or bromide (X ⁇ Br)
- a final step is removal of acid blocking group R to yield acids (R ⁇ H) by using conditions which depend on the stability of R and X, but in all cases well known to those skilled in the art such as removal of benzyl by base hydrolysis or of 2-(trimethylsilyl)ethyl by treatment with tetrabutylammonium fluoride.
- Method L--Amides of the acids of the invention compounds can be prepared from the acids by treatment in an appropriate solvent such as dichloromethane or dimethylformamide with a primary or secondary amine and a coupling agent such as dicyclohexylcarbodiimide. These reactions are well known to those skilled in the art.
- the amine component can be simple alkyl or arylalkyl substituted or can be amino acid derivatives in which the carboxyl is blocked and the amino group is free.
- Suitable pharmaceutically acceptable salts of the compounds of the present invention include addition salts formed with organic or inorganic bases.
- the salt forming ion derived from such bases can be metal ions, e.g., aluminum, alkali metal ions, such as sodium of potassium, alkaline earth metal ions such as calcium or magnesium, or an amine salt ion, of which a number are known for this purpose.
- Examples include ammonium salts, arylalkylamines such as dibenzylamine and N,N-dibenzylethylenediamine, lower alkylamines such as methylamine, t-butylamine, procaine, lower alkylpiperidines such as N-ethylpiperidine, cycloalkylamines such as cyclohexylamine or dicyclohexylamine, 1-adamantylamine, benzathine, or salts derived from amino acids like arginine, lysine or the like.
- the physiologically acceptable salts such as the sodium or potassium salts and the amino acid salts can be used medicinally as described below and are preferred.
- salts which are not necessarily physiologically acceptable are useful in isolating or purifying a product acceptable for the purposes described below.
- the use of commercially available enantiomerically pure amines such as (+)-cinchonine in suitable solvents can yield salt crystals of a single enatiomer of the invention compounds, leaving the opposite enantiomer in solution in a process often referred to as "classical resolution.”
- classical resolution As one enantiomer of a given invention compound is usually substantially greater in physiological effect than its antipode, this active isomer can thus be found purified in either the crystals or the liquid phase.
- the salts are produced by reacting the acid form of the invention compound with an equivalent of the base supplying the desired basic ion in a medium in which the salt precipitates or in aqueous medium and then lyophilizing.
- the free acid form can be obtained from the salt by conventional neutralization techniques, e.g., with potassium bisulfate, hydrochloric acid, etc.
- the compounds of the present invention have been found to inhibit the matrix metalloproteases MMP-3, MMP-9 and MMP-2, and to a lesser extent MMP-1, and are therefore useful for treating or preventing the conditions referred to in the background section.
- MMPs matrix metalloproteases
- MMP-9 and MMP-2 matrix metalloproteases
- MMP-2 matrix metalloproteases
- MMP-2 matrix metalloproteases
- MMP-2 matrix metalloproteases
- MMP-1 matrix metalloproteases
- the method of treating matrix metalloprotease-mediated conditions may be practiced in mammals, including humans, which exhibit such conditions.
- inhibitors of the present invention are contemplated for use in veterinary and human applications. For such purposes, they will be employed in pharmaceutical compositions containing active ingredient(s) plus one or more pharmaceutically acceptable carriers, diluents, fillers, binders, and other excipients, depending on the administration mode and dosage form contemplated.
- Administration of the inhibitors may be by any suitable mode known to those skilled in the art.
- suitable parenteral administration include intravenous, intraarticular, subcutaneous and intramuscular routes.
- Intravenous administration can be used to obtain acute regulation of peak plasma concentrations of the drug.
- Improved half-life and targeting of the drug to the joint cavities may be aided by entrapment of the drug in liposomes. It may be possible to improve the selectivity of liposomal targeting to the joint cavities by incorporation of ligands into the outside of the liposomes that bind to synovial-specific macromolecules.
- intramuscular, intraarticular or subcutaneous depot injection with or without encapsulation of the drug into degradable microspheres e.g., comprising poly(DL-lactide-co-glycolide) may be used to obtain prolonged sustained drug release.
- degradable microspheres e.g., comprising poly(DL-lactide-co-glycolide)
- an i.p. implanted reservoir and septum such as the Percuseal system available from Pharmacia.
- Improved convenience and patient compliance may also be achieved by the use of either injector pens (e.g. the Novo Pin or Q-pen) or needle-free jet injectors (e.g. from Bioject, Mediject or Becton Dickinson).
- Prolonged zero-order or other precisely controlled release such as pulsatile release can also be achieved as needed using implantable pumps with delivery of the drug through a cannula into the synovial spaces.
- implantable pumps with delivery of the drug through a cannula into the synovial spaces.
- Examples include the subcutaneously implanted osmotic pumps available from ALZA, such as the ALZET osmotic pump.
- Nasal delivery may be achieved by incorporation of the drug into bioadhesive particulate carriers ( ⁇ 200 ⁇ m) such as those comprising cellulose, polyacrylate or polycarbophil, in conjunction with suitable absorption enhancers such as phospholipids or acylcarnitines.
- bioadhesive particulate carriers ⁇ 200 ⁇ m
- suitable absorption enhancers such as phospholipids or acylcarnitines.
- Available systems include those developed by DanBiosys and Scios Nova.
- Oral delivery may be achieved by incorporation of the drug into tablets, coated tablets, dragees, hard and soft gelatine capsules, solutions, emulsions or suspensions. Oral delivery may also be achieved by incorporation of the drug into enteric coated capsules designed to release the drug into the colon where digestive protease activity is low. Examples include the OROS-CT/OsmetTM and PULSINCAPTM systems from ALZA and Scherer Drug Delivery Systems respectively.
- Rectal delivery may be achieved by incorporation of the drug into suppositories.
- the compounds of this invention can be manufactured into the above listed formulations by the addition of various therapeutically inert, inorganic or organic carriers well known to those skilled in the art.
- these include, but are not limited to, lactose, corn starch or derivatives thereof, talc, vegetable oils, waxes, fats, polyols such as polyethylene glycol, water, saccharose, alcohols, glycerin and the like.
- the amount of the pharmaceutical composition to be employed will depend on the recipient and the condition being treated. The requisite amount may be determined without undue experimentation by protocols known to those skilled in the art. Alternatively, the requisite amount may be calculated, based on a determination of the amount of target enzyme which must be inhibited in order to treat the condition.
- the matrix metalloprotease inhibitors of the invention are useful not only for treatment of the physiological conditions discussed above, but are also useful in such activities as purification of metalloproteases and testing for matrix metalloprotease activity.
- activity testing can be both in vitro using natural or synthetic enzyme preparations or in vivo using, for example, animal models in which abnormal destructive enzyme levels are found spontaneously (use of genetically mutated or transgenic animals) or are induced by administration of exogenous agents or by surgery which disrupts joint stability.
- Analytical thin-layer chromatography was performed on Whatman® pre-coated glass-backed silica gel 60 A F-254 250 ⁇ m plates. Visualization of spots was effected by one of the following techniques: (a) ultraviolet illumination, (b) exposure to iodine vapor, (c) immersion of the plate in a 10% solution of phosphomolybdic acid in ethanol followed by heating, and (d) immersion of the plate in a 3% solution of p-anisaldehyde in ethanol containing 0.5% concentrated sulfuric acid followed by heating.
- HPLC high performance liquid chromatography
- MS Mass spectral data were obtained on a Kratos Concept 1-H spectrometer by liquid-cesium secondary ion (LCIMS), an updated version of fast atom bombardment (FAB). Most of the compounds systhesized in the experiments below were analyzed by mass spectroscopy, and the spectra were consistent with the proposed structures in each case.
- LIMS liquid-cesium secondary ion
- FAB fast atom bombardment
- Example 1 (MP 138.5°-139.5° C.) as a white fluffy solid and 4.0 mg of Example 6 (MP 185.5°-186.5° C.) as side product from succinic anhydride as a minor impurity of dihydro-3-(2-methylpropyl)-2,5-furandione prepared by the procedure in Wolanin, et al., U.S. Pat. No. 4,771,038 (Sep. 13, 1988--Examples 6 and 5c)!.
- Example 1 The mother liquors from a similarly prepared batch of Example 1 were evaporated in vacuo and the residue evaluated by NMR spectroscopy to show the presence of an isomer, 5-methyl-3- oxo-(4'-chloro-4-biphenyl)methyl!hexanoic acid, as a significant component.
- This residue was prepurified by flash silica chromatography (methylene chloride-methanol) to remove extraneous contaminants and then separated on a Chiralpak AD® HPLC column (65% n-heptane, 35% (1% water+0.2% TFA in ethanol)) to yield enantiomers of the regioisomer (Example 4/Example 5 mixed) along with those of Example 1.
- Example 2 Separation of pure Example 1 on the same system yielded only the isomers of this compound as Example 2 (first off) and Example 3 (second off).
- Example 1 The mother liquors from recrystallization were a mixture of regioisomers and a small amount of Example 6.
- Example 1 The above methods for the preparation of Example 1 were used to prepare the following series of biphenyl products (TABLE I) using the appropriately substituted anhydride and the appropriately substituted biphenyl.
- Example 1 The above methods for the preparation of Example 1 were used to prepare the following series of phenyl containing products (TABLE II) using the appropriately substituted anhydride and the appropriately substituted aryl starting material.
- Example 1 The above methods for the preparation of Example 1 were used to prepare the following series of olefin containing products (TABLE III) using the appropriately substituted anhydride along with the appropriately substituted aryl starting material.
- Example 19 (52.2 mg, 0.153 mmol) was dissolved in 2.5 ml glacial acetic acid and 1.5 ml conc. HBr. This mixture was stirred overnight at ambient temperature and then refluxed for 13 hours. The reaction was allowed to cool before water was added to precipitate crude solid. This was dissolved in ethyl acetate and washed with brine. The solution was dried over MgSO 4 and concentrated in vacuo to give a solid that recrystallized from hexane-ethyl acetate as 24.6 mg white crystals. MP 188.0°-189.0° C. ##STR45##
- Example 6 (127.2 mg, 0.441 mmol) was dissolved in 2 ml of pyridine. To this solution was added 32 mg of paraformaldehyde and 0.5 ml of piperidine. The mixture was heated in an oil bath at 55°-60° C. for 6 hours, then allowed to stir at ambient temperature overnight. The reaction was poured into 10% HCl and extracted with EtOAc, washed with saturated brine, dried over MgSO 4 , filtered and solvent was removed in vacuo to give a crude solid. This solid was dissolved in EtOAc and filtered through a cotton plug to remove insoluble material. The residue was recrystallized with Hexane-EtOAc to give 54.4 mg (41%) white crystals. MP 127.0°-128.0° C. ##STR46##
- Example 1 (103.5 mg, 0.300 mmol) was dissolved in 20 ml of water with the addition of 30.0 mg (0.687 mmol) of sodium hydroxide. The solution was cooled in an ice bath and then 13.0 mg (0.344 mmoles) of sodium borohydride was added as a solid. Stirring continued for 1 h. TLC (methylene chloride-2.5% methanol) indicated that starting material was still present, so the reaction was allowed to warm to room temperature overnight (16.5 h). Starting material was still present, so 13.0 mg more sodium borohydride was added at room temperature. The reaction was stirred for 2 h and then quenched with 10% HCl and extracted twice with ethyl acetate.
- TLC methylene chloride-2.5% methanol
- Example 35 and Example 36 were prepared by dissolving a mixture of Example 33 and Example 34 (51 mg) in 25 ml benzene along with camphor sulfonic acid (11 mg). This mixture was refluxed for 12 hours using a Dean-Stark trap. The resultant solution was washed with aqueous sodium bicarbonate, dried over MgSO 4 and evaporated in vacuo. The residue was purified by silica gel chromatography with Hexane-EtOAc to give the separated lactones.
- Example 23 The general method of Example 23 was used to prepare Example 37 by using acetyl chloride instead of itaconic anhydride. MP 100°-101° C. ##STR49##
- Example 23 (97.9 mg, 0.325 mmol) was dissolved in 1.0 ml of a 0.446M solution of potassium hydroxide in water. Slowly, 76.8 mg (2.030 mmol) of sodium borohydride was added. The mixture was stirred at room temperature for 15 h. The reaction was quenched by addition of 6N HCl and extracted twice with ethyl acetate and the combined organic extracts washed once with brine. The solution was dried over MgSO 4 and concentrated in vacuo. The white solid was recrystallized (hexane-ethyl acetate) to provide 57.1 mg of white solid Example 38. MP 118°-120° C. ##STR50##
- Example 39 was prepared from Example 9 in a way similar to the preparation of Example 38.
- Anal. C calcd, 67.83; found, 67.80.
- H calcd, 5.12; found, 5.50, with calcd 0.5 H 2 O.
- Example 40 (300 mg, 0.60 mmol) was dissolved in DMF (3 mL) and treated with ethyl acrylate (0.15 mL, 1.38 mmol), Pd(OAc) 2 (15 mg, 0.07 mmol), sodium bicarbonate (126 mg, 1.50 mmol), and tetrabutylammonium chloride (69 mg, 0.24 mmol). The mixture was refluxed for 3 days at which time it was diluted with ethyl acetate and transferred to a separatory funnel. The organic layer was washed with water, brine, dried over MgSO 4 , and the solvent removed at reduced pressure. The crude product was chromatographed with 0-4% methanol in methylene chloride to afford 120 mg of product. MP 155°-157° C. ##STR58##
- Example 42 A suspension of Example 42 (28 mg, 0.06 mmol) in ethanol (1.5 mL) was treated with a solution of NaOH (14 mg, 0.35 mmol) in water (0.3 mL) and the mixture was stirred at room temperature overnight. At this time, it was quenched with 2N HCl and extracted with methylene chloride (2 ⁇ 10 mL). The combined extracts were washed with brine, dried over MgSO4, and the solvent removed at reduced pressure to afford 23 mg (87%) of product. MP 230°-232° C. ##
- Example 42 A solution of Example 42 (60 mg, 0.13 mmol) in ethanol (2 mL) was treated with 10% Pd on C (10 mg) and the mixture was stirred at room temperature overnight under a hydrogen gas balloon. At this time, the reaction mixture was filtered through celite and the solvent was removed at reduced pressure to afford 43 mg of product as oil. MS (FAB-LSIMS) 458 M! + . ##STR60##
- Example 44 A suspension of Example 44 (15 mg, 0.03 mmol) in ethanol (1 mL) was treated with a solution of sodium hydroxide (9 mg, 0.23 mmol) in water (0.2 mL) and allowed to stir at room temperature for 1.5 days. The reaction mixture was then quenched with 2N HCl, diluted with ethyl acetate and the layers were separated. The organic layer was washed with brine, dried over MgSO 4 , and the solvent was removed at reduced pressure to afford 12 mg of product. MP 131°-132° C. ##
- Example 41 50 mg, 0.12 mmol, Cu(I)CN (36 mg, 0.40 mmol), and 0.7 mL of 1-methyl-2-pyrrolidinone were mixed and heated at 125° C. for 24 h. The reaction mixture was diluted with methylene chloride and evaporated at reduced pressure. The crude product was then chromatographed with 0-8% methanol in methylene chloride on the MPLC to afford 26.5 mg (66% yield) of product. HRMS (FAB) calcd. for C 21 H 22 NO 3 S M+H! + 336.15997, Found 336.16129.
- the methyl ester (93 mg) was dissolved in 3 mL of ethanol and treated with 5 eq of sodium hydroxide in 0.5 mL of H 2 O. The mixture was stirred at room temperature for 10 h at which time TLC showed complete hydrolysis of the methyl ester.
- the reaction mixture was acidified with 2N HCl, diluted with ethyl acetate, and the layers were separated. The organic layer was washed with brine, dried over MgSO 4 , and the solvent removed at reduced pressure to afford 82 mg of product. MP 169°-171° C.
- Example 47 The above methods for the preparation of Example 47 were used to prepare the following series of biphenyl products (TABLE IV) using the appropriate bromides instead of 4-bromo-Boc-aniline in step 4.
- Example 56 The methyl ester of Example 56 (81 mg, 0.2 mmol, from treatment of an ethanol solution of Example 56 with diazomethane followed by solvent evaporation in vacuo) was dissolved in 1 mL of toluene and treated with trimethyltin azide (62 mg, 0.3 mmol). The reaction mixture was refluxed for 5 days. At this time, the reaction mixture was cooled to room temperature, diluted with ethyl acetate, washed with brine and dried over MgSO 4 . The crude product was chromatographed with 0-20% methanol in methylene chloride to afford 56 mg of the methyl ester tetrazole product.
- Example 47 (46 mg, 0.094 mmol) was dissolved in 1.5 mL of methylene chloride and treated with trifluoroacetic acid (0.16 mL, 2.06 mmol). The mixture was stirred at room temperature for 32 h, when TLC showed complete reaction. The solvent was removed at reduced pressure and the solid obtained was washed with ethyl acetate/hexanes to afford 40 mg of product as TFA salt. MP 170°-174° C. (dec.). ##STR69##
- Example 58 The methyl ester of Example 58 (50 mg, 0.13 mmol) in methanol/tetrahydrofuran (0.7 mL/0.4 mL) was treated with 37% aqueous formaldehyde (0.11 mL, 1.46 mmol), glacial acetic acid (0.032 mL), and sodium cyanoborohydride (0.32 mL, 1.0M in THF, 0.32 mmol). The reaction mixture was stirred at room temperature for 2 h at which time the solvent was removed at reduced pressure and saturated potassium carbonate was added to the residue. Ethyl acetate was added to the mixture and the layers were separated.
- the methyl ester product (47 mg, 0.11 mmol) was suspended in ethanol (2 mL) and treated with 10 eq of sodium hydroxide in H 2 O (1 ml). The mixture was stirred at room temperature for 16 h at which time TLC showed complete reaction. The ethanol was then removed at reduced pressure, the residue was diluted with ethyl acetate, and the mixture was acidified with 2N HCl. At this time, the layers were separated and the organic portion was washed with brine, dried over MgSO 4 , and the solvent removed at reduced pressure to afford 48 mg (96% yield) of product as the hydrochloride salt. MP 166°-168° C.
- a three neck 2 L flask equipped with a mechanical stirrer was charged, under argon atmosphere, with a potassium tert-butoxide/tert-butanol solution (800 mL, 1.0M) and brought to reflux.
- Isobutyraldehyde (66.2 mL, 729 mmol) and diethyl succinate (151 mL, 907 mmol) were combined and added dropwise over 0.5 h.
- the reaction solution was refluxed an additional 1.5 h and cooled to ambient temperature.
- the solution was diluted with ethyl acetate (800 mL) and washed with 2N hydrochloric acid solution (500 mL).
- a solution of trimethylsilyl tin chloride (21.8 g, 109.5 mmol) in freshly distilled dimethoxyethane (50 mL) was added to a suspension of sodium (7.6 g, 330 mL), naphthalene (200 mg, 1.56 mmol), and dimethoxyethane under argon atmosphere cooled to -20° C. After 2.5 h, the suspension had turned to a dark green color. The solution was then decanted from excess sodium.
- a solution of 1,4 dibromopyridine (10 g, 42.2 mmol) and dimethoxyethane was added over 0.3 hours at 0° C. under argon. The solution was slowly warmed to ambient temperature, the poured into 500 mL water.
- Potassium carbonate (100 mg) was suspended in a solution of the acid chloride from step 3 (1.91 g, 9.6 mmol), the product of step 4 (3.9 g, 9.6 mmol) and toluene (50 mL). This was then refluxed 48 h before being cooled to ambient temperature and diluted with ethyl acetate. Solids were filtered off and solvent removed. The remaining oil was chromatographed on silica with an ethyl acetate/hexane eluent.
- the resulting material was coupled to p-iodo ethyl benzene (1 eq) by refluxing in a solution of tetrahydrofuran in the presence of bis-(triphenylphosphine) palladium (II) chloride (20 mole %).
- the coupled product was chromatographed on silica with ethyl acetate/hexanes and saponified by addition of sodium hydroxide to an aqueous ethanol solution. Acidification to pH 5 afforded a yellow solid which was filtered off and recrystallized from ethyl acetate/hexanes. This afforded 53 mg of Example 61. MP 111°-112° C.
- a one-necked, 50-mL, round-bottomed flask equipped with a rubber septum and an argon needle inlet was charged with 7 mL THF, sodium hydride (0.058 g, 2.42 mmol) and cooled to 0° C. while diethyl isobutylmalonate (0.476 g, 0.491 mL, 2.20 mmol) was added dropwise via syringe over ca. 2 min. The resulting mixture was stirred for 30 min at 0° C. and 1 h at room temperature. The reaction mixture was then cooled to 0° C.
- step 1 (A) A one-necked, 10-mL, round-bottomed flask equipped with a reflux condenser fitted with an argon inlet adapter was charged with 4 mL toluene, the product of step 1 (A) (0.100 g, 0.242 mmol), hexamethyl ditin (0.159 g, 0.484 mmol), tetrakis(triphenyl-phosphine)palladium (0.014 g, 0.0121 mmol), and heated at reflux for 24 h. The resulting mixture was concentrated to provide a black oil.
- step 2 A one-necked, 10-mL, round-bottomed flask equipped with a reflux condenser fitted with an argon inlet adapter was charged with 1 mL dimethoxyethane or toluene, the product of step 2 (A) (0.107 g, 0.215 mmol), 1-bromo-3,4-dichlorobenzene (0.097 g, 0.429 mmol), tetrakis(triphenylphosphine)palladium (0.025 g, 0.0216 mmol), and heated at reflux for 24 h. The resulting mixture was concentrated to provide a black oil.
- step 3 A one-necked, 10-mL, round-bottomed flask equipped with an argon inlet adapter was charged with 3 mL ethanol, product of step 3 (B) (0.069 g, 0.128 mmol), and 1 mL of an aqueous 25% sodium hydroxide solution. The resulting mixture was stirred for 10 h at room temperature. The reaction mixture was acidified with a 10% HCl solution, and extracted three times with 20-mL portions of ether.
- step 3 (A) Treatment of the product of step 3 (A) (0.050 g, 0.104 mmol) according to the general procedure of Example 62 afforded 0.010 g (25%) of Example 64 which was recrystallized once from ethyl acetate-hexanes to provide a white solid. MP 132° C.
- step 2 Treatment of the product of step 1 (B) of the Example 62 preparation (13.34 g, 28.06 mmol) according to the general procedure of Example 62, step 4 (B) afforded 4.36 g (41%) of the above 4-bromophenyl intermediate which was recrystallized once from 1-chlorobutane to provide a white solid. MP 147° C. ##STR85## Step 2
- step 2 (A) of the example 64 preparation Treatment of the 4-bromophenyl intermediate from step 1 (1.00 g, 2.66 mmol) in the presence of anhydrous K 2 CO 3 , according to the general procedure of step 2 (A) of the example 64 preparation afforded 0.706 g (58%) of the 4-trimethylstannylphenyl compound as a white solid.
- a one-necked, 10-mL, round-bottomed flask equipped with a reflux condenser fitted with an argon inlet adapter was charged with 3 mL toluene, the product of step 2 (0.050 g, 0.108 mmol), 1-bromo-3,4-dichlorobenzene (0.049 g, 0.217 mmol), and tetrakis(triphenylphosphine)palladium (0.013 g, 0.0112 mmol).
- the resulting mixture was heated at reflux for 24 h, and then concentrated to provide a black oil.
- Example 65 Column chromatography on 15 g of silica gel (elution with 20% ethyl acetate-hexanes containing 0.5% acetic acid) afforded 0.033 g (69%) of Example 65 which was recrystallized once from ethyl acetate-hexanes to provide a white solid. MP 137° C.
- Example 65 The above methods for the preparation of Example 65 were used to prepare the following series of biphenyl products (TABLE V) using the appropriate bromides in step 3.
- a one-necked, 100-mL, round-bottomed flask equipped with a reflux condenser fitted with an argon inlet adapter was charged with 30 mL toluene, the product of step 1 of the example 65 preparation (1.00 g, 2.66 mmol), 4-methoxybenzeneboronic acid (1.60 g, 10.5 mmol), sodium carbonate or potassium carbonate (1.60 g, 11.6 mmol) and tetrakis(triphenylphosphine)palladium (0.300 g, 0.260 mmol).
- the resulting mixture was heated at reflux for 12 h. After cooling to room temperature, 5 mL of 30% hydrogen peroxide solution was added and the resulting mixture stirred for 1 h.
- Example 73 was recrystallized once from 1-chlorobutane to provide a white solid. MP 169° C.
- Example 73 The above method for the preparation of Example 73 was used to prepare the following series of biphenyl products (TABLE VI) using the appropriate boronic acid.
- Example 73 (0.751 g, 1.86 mmol), and 20 mL 48% hydrobromic acid. The resulting mixture was heated at 90° C. for 12 h. After cooling to room temperature, 100 mL of ethyl acetate was added and the resulting mixture was washed twice with 100 mL of water, and once with 100 mL saturated sodium chloride solution. The organic phase was dried over MgSO 4 , filtered, and concentrated to afford a brown solid. Column chromatography on 50 g of silica gel (5% methanol-methylene chloride) afforded 0.530 g (73%) of Example 83 as a white solid. MP 189° C.
- Example 83 (0.100 g, 0.257 mmol). Sodium hydride (0.014 g, 0.583 mmol) was added and the reaction mixture stirred 10 min at room temperature. 1-lodopropane (0.130 g, 0.075 mL, 0.765 mmol) was added and the resulting mixture heated to 60° C. for 12 h.
- reaction mixture was diluted with 50 mL of ethyl acetate, washed twice with 20 mL of water, and washed once with 20 mL saturated sodium chloride solution.
- the organic phase was dried over MgSO 4 , filtered, and concentrated to afford an oil.
- a second, one-necked, 10-mL, round-bottomed flask equipped with a rubber septum and an argon needle inlet was charged with the above oil, 1 mL THF, 1 mL methanol, and 2 mL of a 1M sodium hydroxide solution.
- Example 84 was stirred 10 min at room temperature, dissolved in 20 mL ethyl acetate and washed twice with 20 mL of a 10% HCL solution. The organic phase was dried over MgSO 4 , filtered, and concentrated to afford, after HPLC purification, 0.014 g (13%) of Example 84 as a white solid. MP 126° C.
- Example 84 The above method for the preparation of Example 84 was used to prepare the following series of biphenyl products (TABLE VII) using the appropriate alkylating agent.
- a dry 2-L, three-necked, round-bottomed flask was equipped with a stir bar, a pressure equalizing addition funnel, an argon inlet and a thermometer.
- the flask was charged with a suspension of sodium hydride (8.4 g of 95% NaH; ⁇ 0.33 mol) in dry THF (700 mL) and was cooled with an ice water bath. Diethyl malonate (48.54 g, 0.30 mol) was added dropwise from the addition funnel over 25 min. Stirring was continued for 1.5 h before adding 1-bromo-3-phenylpropane (47 mL, ⁇ 61 g, ⁇ 0.30 mol) over 10 min via the addition funnel.
- a 2-L, three-necked, round-bottomed flask was equipped with a mechanical stirrer, a thermometer and an argon inlet.
- the flask was charged with a solution of 4-chlorobiphenyl (48.30 g, 0.256 mol) in dichloromethane (500 mL, freshly opened bottle).
- Bromoacetyl bromide 23 mL, ⁇ 53.3 g, ⁇ 0.26 mol
- the thermometer was temporarily removed and AlCl 3 was added portionwise over 5 min. The internal temperature rose to 10° C. and white gas evolved from the opaque olive green reaction mixture.
- a dry 1-L, three-necked, round-bottomed flask was equipped with a magnetic stir bar, a thermometer, an argon inlet and a pressure equalizing addition funnel.
- the flask was charged with a suspension of sodium hydride (4.7 g of 95% NaH; ⁇ 0.185 mol) in dry THF (400 mL), and the addition funnel was charged with the malonate product from step 1 (46.76 g, 0.168 mol).
- the reaction vessel was cooled with an ice water bath while the malonate was added dropwise over 18 min.
- the diacid product from step 3 (28.34 g, 62.85 mmol) was dissolved in 1,4-dioxane (1.2 L) and was held at reflux under argon overnight. Concentration gave the crude product as a yellow-white solid (27.60 g) which was recrystallized from toluene to deliver the title compound Example 114 as a tan solid (21.81 g, 53.60 mmol) after overnight drying in a vacuum oven at 100° C. The decarboxylation was repeated on the remaining diacid (12.38 g) from step 3 to give additional recrystallized product (7.60 g, 18.68 mmol). The total yield for the decarboxylation step was 80%.
- the final product contains 5 mol % toluene even after extensive vacuum oven drying at 100° C.
- Anal. for C 25 H 23 O 3 Cl. 0.05C 7 H 8 ) C: calcd, 73.99; found, 73.75 H: calcd, 5.73; found, 5.74.
- dehydroabietylamine (60%, 100 g, 0.21 mol) in toluene (170 mL) was treated with a second solution of glacial acetic acid (24 mL) in toluene (55 mL) at room temperature. The mixture was stored at room temperature overnight. The crystalline salt was collected by filtration, washed with cold toluene and recrystallized from boiling toluene (152 mL). The crystals were collected by filtration, washed with n-pentane and air-dried to give dehydroabietylamine acetate (47 g, 78%) as a white crystalline solid.
- dehydroabietylamine acetate 47 g, 0.16 mol
- water 175 mL
- An aqueous solution of NaOH (10% W/V, 61 mL) was carefully added and after cooling to room temperature.
- the aqueous solution was extracted with diethyl ether, dried over MgSO 4 , filtered and concentrated to give dehydroabietylamine (35 g, 58%) as a viscous oil which solidified on standing. MP 44°-45° C.
- Example 114 A solution of Example 114 (45 g, 0.11 mol) and dehydroabietylamine (32 g, 0.11 mol) in an acetone/ethanol/water mixture (50:20:1; 1260 mL) was carefully warmed until the solution became clear (1 h). After cooling to room temperature and standing for 42 h, the solid was removed by filtration.
- the solid product from the initial crystallization was diluted with a 10% dichloromethane/ethyl acetate mixture (700 mL) and treated with 10% phosphoric acid (300 mL). After stirring at room temperature for 1 h, the mixture was added to a separatory funnel and diluted with sat. aq. NaCl (200 mL). After the aqueous phase was drained off, the precipitate that remained in the organic layer was removed by filtration and dried to give 9.2 g of near racemic solid with an isomer ratio of 48:52 (Example 116:Example 115).
- Example 115 (13.3 g, 60% theoretical; isomer ratio 0.8:99.2 (Example 116:Example 115)). MP 125°-126° C.; ⁇ ! D +25.70° (c 1.4, acetone).
- Example 115 The filtrate from the initial crystallization in step 2 of the procedure for the preparation of Example 115 was concentrated under reduced pressure. The resulting solid material was processed using the same procedure as described for Example 115.
- the analogous sequence provided racemate (8.0 g, isomer ratio 57:43) and Example 116 (13.5 g, 60% theoretical; isomer ratio 99.1:0.9). MP 125°-126° C., ⁇ ! D -25.60° (c 1.4, acetone).
- Example 114 Example 115, and Example 116 were used to prepare the following series of biphenyl containing products (TABLE VIII) using the appropriate alkylating agent in step 1 and the appropriately substituted biaryl starting material in step 3.
- Example 124 (1.15 g, 2.85 mmol), 10% Pd/C (0.06 g), and glacial acetic acid (50 mL) was charged with hydrogen gas at 55 psi and shaken on a Parr apparatus until hydrogen uptake ceased.
- the Parr reaction vessel was then purged with argon and the reaction mixture was filtered through a pad of Celite, rinsing with acetone.
- the solution was concentrated to dryness via rotary evaporation using hexane to azeotrope the acetic acid.
- the solid was dissolved in hot 10% HCl, filtered and concentrated to dryness via rotary evaporation.
- the crude hydrochloride was then recrystallized from ethanol to afford off-white crystals which when dried in a vacuum oven (80° C., 3 days) became purple (0.18 g, 17%).
- Example 136 (0.30 g) was suspended in ethyl acetate (7 mL) and treated with aqueous K 2 CO 3 (1.93 g in 7 mL) followed by benzyl chloroformate (0.165 mL). The mixture was stirred over the weekend. The reaction was partitioned between 10% HCl and ethyl acetate/methylene chloride. The organics were washed with water and brine, dried (Na 2 SO 4 ) and concentrated to a yellow solid. Flash column chromatography (gradient elution, methylene chloride to 98:2 methylene chloride-methanol) gave the desired as a white solid. MP 148°-149° C.
- Example 137 Using the appropriate commercially available acylating agents, the general method of Example 137 was used to prepare the examples in Table IX from Example 136.
- Examples 140-141 were prepared by hydrolysis of the product from acylation of the ethyl ester of Example 136.
- Acid Example 126 was dissolved in dimethylsulfoxide (1.5 mL) and methanol (1 mL). Triethylamine (0.21 mL, 1.51 mmol) was added followed by palladium(II) acetate (12.8 mg, 0.057 mmol) and 1,3-bis(diphenylphosphino)propane (23.0 mg, 0.056 mmol). Carbon monoxide was bubbled through the solution for three minutes. The orange solution was placed under a carbon monoxide atmosphere and was heated in an oil bath at 70°-75° C. The reaction was worked up after 20 h 45 min of heating.
- Half acid ester Example 142 was dissolved in ethanol (3 mL), tetrahydrofuran (3 mL) and aqueous NaOH (0.20 g in 1 mL). The mixture still contained starting material after stirring for 4.5 h. 50% aqueous NaOH (1 mL) was added and the mixture was stirred overnight. The mixture was acidified with 10% HCl and extracted with ethyl acetate/chloroform. The extracts were dried (Na 2 SO 4 ) and concentrated to a black solid which did not completely dissolve in fresh ethyl acetate. The suspension was filtered through celite and was concentrated to a yellow solid (354 mg).
- Example X The examples in Table X were prepared by the palladium-mediated carbonylation method of Example 142 with water or the appropriate amine in place of the methanol.
- Example 153 was prepared from the ethyl ester of Example 144 by using water in the carbonylation method of Example 142 followed by hydrolysis according to the procedure of Example 143.
- Examples 145 and 146 are the separate stereoisomers of the racemate from Example 144. Separation was accomplished on a Chiralpak AS column (65:35 hexanes-absolute ethanol with 1% acetic acid) and the stereochemistry of the individual isomers was assigned by analogy to the relative activity of other definitive isomer pairs.
- Example 154 The methyl ether of Example 154 was cleaved according to the general procedure of Example 83 to give Example 155 as a white solid. MP 165.5-°166° C.
- Example 155 Reaction of Example 155 with the appropriate alkylating agent according to the general procedure of Example 84 gave Examples 156-159 (TABLE XI). Reaction of the ethyl ester of Example 155 with the appropriate alkylating agent according to the general procedure of Example 84 delivered Examples 160 and 161.
- a one-necked, 1000-mL, round-bottomed flask equipped with an argon inlet adapter was charged with 500 mL CH 2 Cl 2 , 4-phenylphenol acetate (50.0 g, 235 mmol), bromoacetyl bromide (73.2 g, 31.6 mL, 363 mmol) and cooled to 0° C. while aluminum trichloride (94.2 g, 707 mmol) was added in small portions ca. over 5 min. The resulting mixture was stirred for 30 min at 0° C. and 12 h at room temperature. The reaction mixture was added to a cold 10% HCl solution (500 mL), and extracted three times with 200-mL portions of ethyl acetate.
- Example 164 was prepared from Example 162 by the palladium-mediated carbonylation method of Example 142 with diethylamine as the nucleophile.
- Anal. for C 34 H 41 NO 5 .0.75 H 2 O
- C calcd, 73.29; found, 73.35.
- H calcd, 7.69; found, 7.43.
- N calcd, 2.51; found, 2.33. ##STR152##
- Example 165 was prepared from Example 163 by the palladium-mediated carbonylation method of Example 142 with diethylamine as the nucleophile. MP 92°-95° C.
- a dry, 500 mL, three-necked, round-bottomed flask was fitted with a magnetic stirring bar, a three-way stopcock, a low temperature thermometer and a teflon stopper.
- the flask was flushed with argon and charged with tetravinyl tin (5.9 mL, 32.3 mmol) and 50 mL of freshly distilled ether.
- the cooled (0° C.) solution was treated with methyl lithium (86.9 mL of a 1.43M solution in diethyl ether; 124.3 mmol) over 20 min.
- the mixture was stirred at 0° C. for 30 min. cooled to -78° C.
- Example 167 was spectroscopically identical to Example 166.
- Example 166 (1.2 g, 2.59 mmol) was dissolved in glacial acetic acid (30 mL) and 30% HBr in glacial acetic acid (3.5 mL). The solution was stirred overnight. The reaction mixture was diluted with ether (250 mL) and the resultant suspension was stirred for 30 min to break up large chunks of solid. The mixture was filtered and the collected solid was suspended in fresh ether and stirred for 1 h. The solid was collected by filtration and dried under vacuum overnight. The crude product (790 mg, 75%) was used in the next step without further purification. TLC (ethyl acetate-formic acid-water, 8:1:1): R f 0.63.
- step 1 The product of step 1 (100.0 mg, 0.25 mmol) was dissolved in dry tetrahydrofuran (3.2 mL). Triethylamine (73 mL) was added and the resultant suspension was cooled with an ice bath at 0° C. Benzyl isocyanate (34 mL) was added, the ice bath was removed and the mixture was warmed to room temperature with stirring over 3 h. The mixture was diluted with tetrahydrofuran, filtered and concentrated. Flash column chromatography (chloroform with 2% acetic acid) gave the desired as a colorless solid (43.8 mg, 38%). MP 132.0°-134.0° C.
- Example 29 (10 gm, 34.9 mmol) was suspended in dry tetrahydrofuran (100 mL) under argon and cooled to 0° C. First 1,8-diazabicyclo 5.4.0!undec-7-ene (5.2 mL, 34.9 mmol) was added by syringe followed by methyl iodide (6.5 mL, 104.6 mmol). The reaction mixture was warmed to room temperature with overnight stirring. The reaction mixture was filtered and the filter cake was washed with ether. The filtrate was concentrated, the residue was dissolved in dichloromethane and washed with 10% HCl (2 ⁇ 125 mL). The organics were dried (Na 2 SO 4 ) and concentrated to a yellow solid (9.08 g, 87%). TLC (chloroform-methanol, 97.5:2.5): R f 0.90. ##STR166## Step 2
- N-Benzyl-N-(cyanomethyl)-N- (trimethylsilyl)methyl!amine (4.06 gm, 17.5 mmol) and the product from step 1 (5.0 g, 16.6 mmol) were suspended in acetonitrile (40 mL) under argon and enough dichloromethane was added to dissolve all the solids.
- the flask was wrapped in aluminum foil and AgF (2.32 g, 18.3 mmol) was added. The mixture was stirred in the dark overnight. The black mixture was filtered through celite and the filtrates were concentrated to a brown, oily residue.
- step 1 The product mixture of step 1 (2.29 g, 6.49 mmol) was dissolved in tetrahydrofuran (50 mL) and treated with aqueous NaHCO 3 (50 mL). A mixture of iodine (3.11 g, 12.25 mmol) and KI (2.17 g, 13.07 mmol) in water-tetrahydrofuran (2:1, 50 mL) was added rapidly over 3 min and the brown mixture was stirred under argon overnight. The reaction was quenched with saturated aqueous NaHSO 3 and extracted with ethyl acetate. The combined organics were dried and concentrated to a yellow foam.
- step 2 The ketal from step 2 (4.61 g, 12 mmol) was dissolved in THF (45 mL) and H 2 O (15 mL) at rt. NaOH (480 mg, 12 mmol) was added and the reaction stirred at rt for 19 h. Ester was still present by TLC so another portion of NaOH (210 mg) was added. After a further 2 h the reaction was acidified to pH 3 with 4M HCl at 0° C. and the product was extracted with ethyl acetate. Removal of solvent in vacuo gave 4.63 g of a colorless solid that was taken on to the next step crude.
- Benzyloxazolidinone from step 3 (1.0 g, 1.9 mmol) was dissolved in THF (5 mL) and cooled to -70° C.
- Sodium bis(trimethylsilyl)amide (1M in THF, 2.0 mL, 2 mmol) was added to the oxazolidinone over 5 min and the reaction stirred a further 30 min.
- step 5 The product of step 5 (350 mg, 0.53 mmol) was dissolved in THF (3.75 mL) and H 2 O (1.25 mL) and cooled to 0° C. Hydrogen peroxide (30%, 485 mL, 4.2 mmol) then lithium hydroxide monohydrate (90 mg, 2.1 mmol) were added. After 30 min the ice bath was removed and the reaction stirred 6 h at rt. Aqueous sodium bisulfite (10%) was added and the mixture stirred overnight. The aqueous layer was extracted with CH 2 Cl 2 and the organic solution was dried over sodium sulfate.
- the sodium dimethylmalonate solution was transferred via cannula dropwise into the 4(4'-chlorophenyl)-a-bromoacetophenone solution; stirring continued 1 hr at rt.
- the solvent was removed in vacuo and the resulting oil dissolved in 1:1 methylene chloride:diethyl ether (700 mL).
- the organic phase was washed with water (250 mL), and saturated sodium chloride solution (250 mL).
- the organic layer was dried (MgSO 4 ), filtered, and concentrated in vacuo.
- Phosphorous tribromide (2.62 mL, 27.6 mmol) was added to a solution of 3-phenyl-2-propyn-1-ol (10.0 g, 76 mmol) and pyridine (0.14 mL, 1.77 mmol) in diethyl ether (22 mL) at a rate to maintain reflux. After addition, the mixture was heated at 40° C. for 2 h. The mixture was cooled and poured onto ice. The organic layer was separated and diluted with diethyl ether (100 mL), washed with saturated sodium bicarbonate (2 ⁇ 50 mL) and saturated sodium chloride (50 mL).
- Ethyl 2-carboethoxy-4 4'-(4"-chlorophenyl) phenyl!-4-oxobutanoate (0.40 g, 1.02 mmol) was added in one portion at rt to a solution of sodium ethoxide (0.08 g, 1.12 mmol) in DME (1 mL). After 15 min, 4-phenyl-1-iodobutane (0.24 g, 0.93 mmol) in DME (3 mL) was added. The resulting solution was stirred for 18 h. The solvent was concentrated in vacuo and the resulting oil dissolved in CH 2 Cl 2 (100 mL) and washed with water (100 mL).
- step 3 The diester from step 3 was converted to the monoacid following the general method for Example 40 steps 4 and 5. MP 127°-130° C.
- Example 179 The above methods for the preparation of Example 179 were used to prepare the following series of biphenyl containing products (TABLE XIII) using the appropriate alkylating reagent and the appropriately substituted biaryl starting material.
- Example 193 Methods similar to those of Chem. Pharm. Bull. 36(6), 2050-2060, (1988) were used to prepare Example 193 as follows:
- Example 23 In a 250 mL round bottom flask, 9.84 g (32.77 mmol) of Example 23 was dissolved in 48 mL of DMF. The flask was placed under Ar. Thiopivalic acid (8.4 mL, 66.09 mmol, 2 eq) was added to the flask via syringe followed by addition of 3.2 mL of a 1.93M solution of K 2 CO 3 in H 2 O. The mixture was then stirred at 25° C. for 23 h.
- the mixture was extracted with ethyl acetate (100 mL, ⁇ 3).
- the combined organic extracts were washed with water (100 mL, ⁇ 4), dried over magnesium sulfate and concentrated in vacuo to yield crude product (13.16 g, 96% crude).
- Example 193 (1.38 g injected in several portions) was separated by chromatography on a Chiralcel® OJ HPLC column (2 cm ⁇ 25 cm) using 9 ml/min. 85% hexane/15% (0.2% trifluoroacetic acid in ethanol) and peak detection by UV at 320 nM. The best fractions of each isomer were combined and each material was then recrystallized from ethyl acetate/hexane to yield 520 mg of pure Example 194 (first to elute) and 504 mg of pure Example 195 (second to elute).
- Example 193 The above method for the preparation of Example 193 was used to prepare Example 196 using thiophenol and Example 23. MP 125°-126° C.
- Example 196 A solution of Example 196 (24 g, 0.058 mol) and (+)-cinchonine (10 g, 0.034 mol) in acetone (150 mL) was allowed to stand at room temperature for 46 h. The white precipitate was removed by filtration, suspended in ethyl acetate and washed successively with 2N HCl (150 mL) and sat. aq. NaCl (100 mL). The organic layer was dried over MgSO 4 , filtered and concentrated under reduced pressure to give a white solid (8.4 g, isomer ratio 95.3:4.7 (Example 197: Example 198)).
- Example 444 was prepared from the product of step 1 and thiophenol according to the procedure for the preparation of Example 193. Reaction conditions led to cleavage of the acetyl group as well as addition of thiophenol to the acrylate. MP 137°-138° C. ##STR206##
- Example 196 A sample of Example 196 was stored for several days as a solution in a mixed solvent containing tetrahydrofuran which also contained significant quantities of peroxides. This resulted in the formation of significant quantities of the isomeric sulfoxides Example 246, Example 247, Example 248 and Example 249 which were separated into pure fractions by chromatography on chiral HPLC stationary phases. These same compounds can also be isolated from aged samples of Example 196 or its isomers Example 197 or Example 198 or samples of the same materials in solution with added hydrogen peroxide.
- Example 248 and Example 249 are often found as contaminants in aged air oxidized samples of Example 197 and therefore must share the C-2 stereochemistry of Example 197, but differ in the stereochemistry at the sulfoxide oxygen.
- Example 246 a! D -99.7 (c 0.6, acetone) and Example 247 are found in aged samples of Example 198 and therefore share the C-2 stereochemistry of Example 198, but differ in stereochemistry at sulfoxide.
- Example 244 A solution of Example 244 (20.9 mg, 0.0445 mmol) in THF (1.5 mL) was cooled in a dry ice/acetone bath. The reaction vessel was sealed with a rubber septum and methylamine gas was bubbled through for approximately 1 min. The reaction was allowed to warm to room temperature and stirred for several h. Concentration under reduced pressure and recrystallization from ethyl acetate and hexane provided Example 250 as white crystals. MP 185°-186° C.
- Example 29 In a 25 mL round bottom flask, 209.8 mg (0.732 mmol) of Example 29 was dissolved in 5 mL of 1,4-Dioxane. The flask was placed under Ar. Thiophenol, 0.1 mL (0.934 mmol, 1.33 eq) was added to the flask via syringe. The mixture was then stirred at 25° C. At 102 h an additional 0.1 mL of thiophenol was added via syringe. The mixture stirred for a total of 125 h. The reaction was then concentrated in vacuo and the residue was recrystallized from ethyl acetate and hexane to yield 93.0 mg (32%) of white crystals. MP 168°-169° C.
- Example 251 The above method for the preparation of Example 251 was used to prepare the following biphenyl containing products (TABLE XV) using Example 29 and the appropriately substituted thiol starting material.
- This compound was prepared using a method similar to that used for Example 193 except that thiolacetic acid was used instead of thiopivalic acid and Example 28 was used instead of Example 23.
- Example 253 The above method for the preparation of Example 253 was used to prepare the following phenyl containing products (TABLE XVI) using thiol acetic acid and the appropriately substituted olefinic starting material.
- Example 32 195.3 mg (0.650 mmol) of Example 32 and 120.9 mg 2-mercaptothiophene were dissolved in 3 ml of distilled THF. The reaction was purged with argon and stirred at ambient temperature overnight. The volatile components were removed in vacuo to give a crude solid that was recrystallized (EtOAc-hexane) to give 140.0 mg (52%) of Example 255. MP 160.0°-161.0° C.
- Example 255 The above method for the preparation of Example 255 was used to prepare the following series of biphenyl containing products (TABLE XVII) using the appropriate thiol-containing reagent and Example 32.
- Example 29 (0.36 mmol) was dissolved in 10 ml of 1,4-dioxane under argon at ambient temperature. 1.06 eq of thiomorpholine was added to the solution and within 5 minutes a precipitate began to form. Some additional 1,4-dioxane was added to make the mixture easier to stir. Stirring continued overnight. The solid was removed by filtration and dried in vacuo to yield 129 mg of the free base form of Example 259 as a solid product.
- the hydrochloride salt of the product was formed by suspending the initial solid in EtOH and bubbling HCl gas into the suspension until clear. Et 2 O was used to precipitate the salt which was collected by filtration to give final product Example 259. MS (FAB-LSIMS) 390 M+H! + .
- Example 259 The above method for the preparation of Example 259 was used to prepare the following biphenyl containing products (TABLE XVIII) using Example 29 and the appropriate amine starting material. In each case the initial products were converted to hydrochlorides as above before assay as inhibitors of MMPs.
- This compound was prepared using the general procedure of Example 114 except that commercial dimethyl 2-(3-N-phthalimidopropyl)malonate was used instead of ethyl 2-carboethoxy-5-phenylpentanoate. Also the following procedures were used instead of the treatment of the crude oil with NaOH in ethanol/water and successive steps.
- the substituted diester product from steps 1,2, and the first half of 3 was dissolved in a 1:4 solution of concentrated hydrochloric acid:glacial acetic acid in a sealed vessel and heated to 110° C. for 18h. After cooling, solvent was removed under reduce pressure.
- Solution 1 was added to solution 2 and the mixture stirred at 25° C. for 1.5 h.
- the reaction was concentrated in vacuo and the residue dissolved in chloroform.
- the chloroform was washed twice with a 10% solution of potassium carbonate and once with a solution of sodium bisulfite.
- the organic layer was dried over magnesium sulfate, filtered and concentrated in vacuo.
- the resultant solid was mixed with 100 mL of 1N HCl and refluxed for 8 h. The mixture was filtered and the solid was washed with hot ethanol. The ethanol washes were concentrated and crystals were collected. The filtrate was concentrated to dryness and recrystallized from ethyl acetate to produce 15.6 mg (3.7%) of white crystals of Example 263. MP 207°-208° C.
- Example 263 The above method for the preparation of Example 263 was used to prepare the following biphenyl containing products (TABLE XIX). In each case the initial products were converted to hydrochlorides as above before assay as inhibitors of MMPs.
- Example 266 was prepared in a manner similar to Example 263 except that diethyl 2-(3-methylthiopropyl)malonate was used instead of diethyl (2-dimethylaminoethyl)malonate.
- the crude diester intermediate was not washed with base. It was chromatographed over silica gel using hexanes and ethyl acetate. After the final acidification the product was extracted into ethyl acetate and concentrated. The residue was dissolved in 1,4-dioxane and refluxed to decarboxylate. The crude product was then chromatographed over silica gel using ethyl acetate and acetic acid. The product was recrystallized from ethyl acetate and hexane. MP 134°-135° C.
- the concentrate was diluted with dichloromethane (250 mL) and washed successively with satd. aq. K 2 CO 3 and NaCl. The organic layer was dried over MgSO 4 , filtered and concentrated. Crystallization from ethyl acetate provided diallyl (2-phthalimidoethyl) 4'-(4'-chlorophenyl) acetophenone malonate (49.1 g, 83%) as an off white crystalline solid (additional material was recovered with successive recrystallizations): R F 0.4 (30% ethyl acetate:hexanes).
- the diacid could be easily recrystallized from chloroform or ethyl acetate, but was generally taken on to the next step without further purification.
- the diacid was dissolved in 1,4-dioxane (300 mL) and heated to reflux for 36 h. After cooling to room temperature, the solution was concentrated and recrystallized from 1,4-dioxane:toluene to give the desired acid (31 g, 86%) as a white crystalline solid. MP 209°-210° C.
- Example 267 (racemate) was separated into its most active (Example 268 first off column) and less active (Example 269 second off column) enantiomers on a Pirkle type L -Leucine HPLC column using a 2%-acetic acid in ethanol/dichloromethane/hexanes mixture (2/25/73) as an eluent.
- Example 267 The methods for the preparation of Example 267 were used to prepare Example 276 using commercially available N-(bromomethyl)phthalimide in step 2. MP 190°-193° C. ##STR225##
- Example 267 The methods for the preparation of Example 267 were used to prepare Example 431 using commercially available N-(4-bromobutyl)phthalimide in step 2. MP 168°-169° C. ##STR226##
- Example 267 (50 mg, 0.11 mmol) was suspended in 5 ml water. A solution of NaOH (9.1 mg, 0.23 mmol) in 5 mL water was added and stirred for 18 h. Concentrated HCl was added dropwise until the solution was acidified. Precipitate was filtered off and dried in vacuo to afford 33 mg (64%) of the desired product. MP 93°-100° C. ##STR227##
- Example 279 The method for the preparation of Example 279 was used to prepare enantiomerically pure Example 280 from enantiomerically pure Example 268. MP 79°-89° C. ##STR228##
- This compound was prepared by a similar method to that used for Example 23, except that 2,2-dimethylsuccinic anhydride was used instead of itaconic anhydride. MP 179°-180° C.
- Example 282 The above method for the preparation of Example 282 was used to prepare the following biphenyl containing products (TABLE XXI).
- Example 288 To the trans isomer containing mother liquor of Example 288 (110 mg, 0.334 mmol) in THF (5 mL), was added 1,8-Diazabicyclo 5.4.0! undec-7-ene (75 mL, 0.502 mmol) at room temperature. The reaction mixture was stirred under argon for 48 h. Workup consisted of dilution with CH 2 Cl 2 (15 mL), addition of 1N HCl (15 mL), separation, extraction of the aqueous with CH 2 Cl 2 (15 mL ⁇ 3), drying the combined organic layers over MgSO 4 , filtration and concentration in vacuo. The crude product (98 mg, 89%) was purified by HPLC, to provide pure trans compound Example 289 as a white solid. MP 169°-172° C. ##STR236##
- the crude product was purified by chromatography on silica gel to provide 40 mg of the cis isomer as a white solid. MP 154°-156° C.
- Example 292 To a solution of Example 292 (50 mg, 0.166 mmol) in MeOH (20 mL) at room temperature, was added excess K 2 CO 3 . The reaction mixture was stirred at room temperature for 48 h. Workup consisted of addition of 1N HCl (25 mL), extraction of the aqueous layer with CH 2 Cl 2 (4 ⁇ 25 mL), washing the combined organic layers with sat. NaCl (50 mL), drying over MgSO 4 , filtration and concentration in vacuo. The product (50 mg, 100%) was given as a white solid with >99% de in favor of the trans isomer. MP 181°-183° C.
- Example 2 Using the general method of Example 1 except that the solvent was 1,2-dichloroethane and 1-Cyclopentene-1,2-dicarboxylic anhydride was used instead of dihydro-3-(2-methylpropyl)-2,5-furandione, the above compound (27.7 g) was obtained as white crystals in 91% yield. MP 226°-227° C.
- Example 294 Enantiomeric separation of Example 294 was carried out by using a Diacel® AD semi-prep column (2 cm ⁇ 25 cm) with 15% IPA (with 1% H 2 O and 0.1% TFA) in hexane to provide enantiomer Example 296 with >98% ee, and enantiomer Example 297 with >97% ee.
- (+)-enantiomer MP 165°-167° C.
- Example 294 The above methods for the preparation of Example 294 were used to prepare Example 298 using the appropriate commercially available thiol. MP 227°-228° C.
- Example 298 Isomers of Example 298 were separated by chromatography on a chiralpak AD® HPLC column to yield the enantiomers Example 1299 and Example 300.
- Example 301 A 0.6 ml portion of 1N sodium hydroxide was added to a suspension of 100 mg of Example 298 in 3 ml of methanol. After stirring at ambient temperature, tlc assay still showed starting material, so another 0.3 ml of NaOH solution was added and stirring was continued for a total of 40 h, after which tlc showed no starting material remained. Solvent was removed by evaporation in vacuo and the residue was mixed with water and 10% HCl and then extracted several times with ethyl acetate. The combined extracts were (MgSO 4 ) and evaporated in vacuo. The residue was recrystallized from ethyl acetate/hexane to yield 72.6 mg of Example 301 as a white powder. MP 216°-217° C. (dec.).
- Example 295 The racemate from Example 295 was separated into enantiomers by chromatography on a Chiralpak AD® HPLC column. Example 312 eluted first. 1 H-NMR spectra identical to that of Example 295. ##STR252##
- Example 442 was prepared according to steps 1-3 of the procedure for the preparation of Example 315 and Example 316. MP 172°-173° C. ##STR258##
- Example 443 was prepared according to steps 1-3 of the procedure for the preparation of Example 315 and Example 316. MP 174°-177° C. ##STR259##
- Example 317 and Example 318 A mixture (1.8 g) of the compounds Example 317 and Example 318 was separated by chromatography on a Chiralcel OJ® HPLC column to yield the enantiomers of each compound.
- the enantiomers of each compound were identified by having identical 1 H-NMR spectra to their respective racemates.
- Step 3 To a solution of triphenylphosphine (14.64 g, 55.8 mmol) and DEAD (7.99 mL, 50.74 mmol) in THF (100 mL) at room temperature, was added the solution of intermediate from step 2 (6.30 g, 25.37 mmol) in THF ( ⁇ 50 mL). The reaction mixture was refluxed overnight under argon. Workup consisted of concentration in vacuo. The crude product was purified by MPLC twice (2% EtOAc/hexane) to provide the above intermediate (2.85 g, 49%).
- Step 8 To a solution of intermediate from step 6 (205 mg, 0.53 mmol) in toluene (5 mL) at 0° C., was added diethylaluminum cyanide (1N, 2.1 mL, 2.1 mmol) in toluene. The reaction mixture was stirred at room temperature for 2 h under argon. Workup consisted of addition of 1N HCl (20 mL), extraction with EtOAc (4 ⁇ 20 mL), washing the combined organic layers with sat. NaCl, drying over MgSO 4 , filtration and concentration in vacuo. The crude product was carried to the next step. ##STR267## Step 8
- the racemate was made in a similar method to that used for Example 323 except that pentyl 4-(4-bromophenyl)phenyl ether (as prepared in the Example 317 synthesis) was used instead of ethyl 4-(4-bromophenyl)phenyl ether in step 6.
- the racemate was then separated into enantiomers using a Chiralpak AD column with Example 324 eluting first. Intermediates and final products were identified by 1 H-NMR. ##
- Example 326 was obtained through the same synthetic sequence preparing Example 323, by using 4-bromo-4'-chloro biphenyl in the place of ethyl 4-(4-bromophenyl) phenyl ether at step 6. MP 170°-171° C. ##STR271##
- Example 29 To a suspension of 4-Oxo-4-(4'-chloro-4-biphenyl)but-2-enoic acid, Example 29 (0.941 g, 3.28 mmol) in MeOH (5 mL) at room temperature, was added 2,3-dimethyl-1,3-butadiene (2.69 g, 3.71 mL, 32.8 mmol). The reaction mixture was refluxed under argon for a total of 2.5 h. Workup consisted of concentration in vacuo. The crude product was purified by recrystallization from MeOH to yield 950 mg of Example 327 as a white solid. MP 217.0°-220.0° C. ##STR272##
- Example 29 To a suspension of 4-Oxo-4-(4'-chloro-4-biphenyl)but-2-enoic acid, Example 29 (1.01 g, 3.53 mmol) in MeOH (5 mL) at -78° C., was added excess butadiene for 30 min, and followed by addition of DMF (5 mL). The reaction mixture was refluxed under argon for a total of 72 h. Workup consisted of dilution with EtOAc (15 mL), addition of water (15 mL), and extraction of the aqueous layer with EtOAc (3 ⁇ 15 mL). The combined organic layers were washed with sat. NaCl, dried over MgSO 4 , and concentrated in vacuo. The crude product was purified by chromatography (EtOAc/hexane) to yield 140 mg of Example 328 as a white solid. MP 185.0°-186.0° C. ##STR273##
- Example 29 To a suspension of 4-Oxo-4-(4'-chloro-4-biphenyl)but-2-enoic acid, Example 29 (1.208 g, 4.21 mmol) in MeOH (5 mL) at room temperature, was added isoprene (2.87 g, 4.21 mL, 42.1 mmol). The reaction mixture was refluxed under argon overnight. Workup consisted of concentration in vacuo. The crude product was purified by chromatography (EtOAc/hexane) and recrystallization (three times) to yield 20 mg of Example 329 as a white solid. MP 174.0°-177.0° C. ##STR274##
- Example 29 To a solution of 4-Oxo-4-(4'-chloro-4-biphenyl)but-2-enoic acid, Example 29 (1.123 g, 3.915 mmol) in THF (7 mL) at room temperature, was added 5 eq 1,3-cyclohexadiene (1.87 mL, 19.577 mmol). The reaction mixture was stirred under refluxed for 18 h. Workup consisted of concentration in vacuo. The crude product was purified by HPLC to provide the desired product Example 330 (570 mg, 40%) as a white solid containing two isomers. MP 174°-176° C. ##STR275##
- Example 330 The mixture of Example 330 (299 mg, 0.815 mmol) and p-Toluene-sulfono hydrazide (1.5 g, 8.15 mmol) was dissolved in dimethoxyethane (20 mL), and allowed to warm to reflux. A solution of sodium acetate (1.0 g, 12.2 mmol) in water (16 mL) was added over a period of 4 h. The reaction mixture was cooled to room temperature, poured into water (120 mL), and extracted with CH 2 Cl 2 (4 ⁇ 70 mL). The combined organic layers were washed with 150 mL water, dried over MgSO 4 and concentrated in vacuo. The crude product was purified by HPLC to provide the desired product Example 331 (85 mg, 28%). MP 191°-193° C.
- Example 332 The above method for the preparation of Example 332 was used to prepare the following biphenyl containing products (TABLE XXIII).
- This compound was prepared in a similar manner to Example 1, except that 2,2-dimethylglutaric anhydride was used instead of dihydro-3-(2-methylpropyl)-2,5-furandione.
- the crude product was purified via flash column chromatography (gradient elution, dichloromethane to dichloromethane-methanol (99.5:0.5)) followed by recrystallization (ethyl acetate-hexane) to provide white microcrystals of Example 337. MP 163.5°-164.0° C.
- Example 334 From 2-isobutylglutaric anhydride rather than 3-methylglutaric anhydride and using the general procedure of Example 334.
- the crude product was purified via flash column chromatography gradient elution, dichloromethane to dichloromethane-methanol (98.5:1.5)! followed by recrystallization (ethyl acetate-hexane) to provide white microcrystals of Example 338.
- Example 332 From 3,3-pentamethyleneglutaric anhydride rather than 3-methylglutaric anhydride and using the general procedure of Example 332.
- the crude product was purified via flash column chromatography (gradient elution, dichloromethane to dichloromethane-methanol (97:3)) followed by recrystallization (ethyl acetate-hexane) to provide white microcrystals of Example 339.
- n-Butyl lithium (2.64M in hexanes, 0.8 mL, 2.16 mmol) was added dropwise to freshly distilled diisopropylamine (0.3 mL, 0.22 g, 2.16 mmol) in anhydrous tetrahydrofuran (4 mL) at 0° C. and under an argon atmosphere. The solution was stirred for 30 minutes and then cooled to -70° C. A solution of the product from step 2 (0.59 g, 2.06 mmol) in tetrahydrofuran (1 mL, with 0.5 mL rinse) was added via syringe over 20 minutes. Stirring was continued for 75 minutes at -70° C.
- a dry 25-mL round-bottomed flask was charged with a suspension of sodium methoxide (0.26 g of 95% NaOMe, ⁇ 4.75 mmol) and the pure product from step 2 (2.0 g, 4.36 mmol) in dry dimethoxyethane (4.7 mL). Simultaneously, a dry dimethoxyethane (13.5 mL) suspension of 1-bromo-3-phenylpropane (0.67 mL, 0.87 g, 4.36 mmol) and sodium iodide (0.66 g, 4.36 mmol) was formed in a 50-mL round-bottomed flask.
- the two fractions of product from step 2 were reacted separately in this step.
- the order of parenthetical notations of stoichiometry refer to the first fraction and the second fraction respectively.
- Dichloromethane (4.6 mL and 2.9 mL) solutions of each fraction of the product from step 2 (0.36 g, 0.7 mmol and 0.22 g, 0.43 mmol ), anisole (1.9 mL, 1.9 g, 17.5 mmol and 1.17 mL, 1.16 g, 10.75 mmol), and trifluoroacetic acid (0.54 mL, 0.8 g, 7.0 mmol and 0.33 mL, 0.49 g, 4.3 mmol) were formed in separate 25-mL round-bottomed flasks.
- N-methylmorpholine (2.62 mL, 2.41 g, 23.85 mmol) was added quickly via syringe followed by solid 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (3.36 g, 17.49 mmol).
- the reaction mixture was stirred for several hours at 0° C. under inert atmosphere. Stirring was continued while warming to room temperature overnight. After a total of 23 h of stirring, the reaction was incomplete as judged by TLC. Dry N,N-dimethylformamide (2 mL) was added at 0° C. to clarify the reaction mixture.
- n-Butyl lithium (2.64M in hexanes, 10.2 mL, 26.98 mmol) was added dropwise to freshly distilled diisopropylamine (3.78 mL, 2.73 g, 26.98 mmol) in anhydrous tetrahydrofuran (50 mL) at -40° C. and under an argon atmosphere. The solution was stirred for 25 minutes with warming to -20° C. and then cooled to -40° C. A solution of 5-phenylvaleric acid (2.40 g, 13.49 mmol) in tetrahydrofuran (4 mL, with 1 mL rinse) was added via syringe over 7 minutes causing precipitation of a solid.
- N-methylmorpholine oxide (11.4 g, 0.0973 mol, 1.40 eq) in CH 2 Cl 2 (200 mL) was added 4-phenylbutanol (10.2 mL, 0.0696 mol) and powdered 4 ⁇ sieves (2.0 g). After stirring for 10 min, tetrapropylammonium perruthenate (0.218 g, 6.20 mmol. 9 mol %), and the resulting mixture was allowed to stir for 48 h.
- a slurry of product from step 4 of the Example 344 preparation (0.200 g, 0.490 mmol) and diethyl trimethylsilyl phosphite (0.105 g, 0.490 mmol, 1.0 eq) in a dry NMR tube under argon was dissolved using a 50° C. sonicator bath, then heated at 50° C. for 14 h. This was concentrated under reduced pressure and treated with an additional portion of diethyl trimethylsilyl phosphite (0.5 mL) and heated at 50° C. for 24 h.
- Example 1 A dry dichloromethane (3 mL) solution of Example 1 (0.25 g, 0.725 mmol), proline N-methyl amide hydrochloride (0.48 g, 2.90 mmol), and 1-hydroxybenzotriazole (0.10 g, 0.725 mmol) in a 10-mL round-bottomed flask was chilled using an ice bath and stirred for a few minutes. N-methylmorpholine (0.32 mL, 0.29 g, 2.90 mmol) was added quickly via syringe followed by solid 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (0.146 g, 0.76 mmol).
- the reaction mixture was stirred under argon for several hours at 0° C. and was then warmed to room temperature overnight.
- the reaction mixture was then diluted with chloroform (30 mL) and washed with 10% HCl (10 mL).
- the separated aqueous layer was back-extracted with chloroform (5 mL).
- the combined organic portions were washed with saturated NaHCO 3 (10 mL), dried (Na 2 SO 4 ), and concentrated in vacuo.
- the crude oil was purified via flash column chromatography dichloromethane-methanol (98:2)! to provide the title compound as a white solid (0.26 g, 79%).
- step 3 The product of step 3 (56 mg, 0.16 mmol) was suspended in ethanol (1.3 mL) and treated with 4N NaOH (0.4 mL). The mixture was stirred at room temperature overnight. The reaction mixture was then quenched with 2N HCl, diluted with ethyl acetate, and the layers were separated. The organic layer was washed with brine and dried over MgSO 4 . The product was chromatographed with 0-12% methanol in methylene chloride to afford 40 mg (78%) of Example 248 as a solid. MP 120° C. ##STR316##
- step 1 The product of step 1 (0.51 g, 2.17 mmol) was dissolved in THF (10 mL), cooled to 0° C., and treated with phenyltrimethyl-ammonium tribromide (0.84 g, 2.17 mmol). The reaction mixture was then stirred at room temperature for 5 h. The mixture was quenched with H 2 O and extracted with ethyl acetate (2 ⁇ 15 mL). The extracts were washed with brine and dried over MgSO 4 to afford 0.62 g (91%) crystallized from ether/hexanes. TLC (hexanes-10% ethyl acetate) R f 0.27. ##STR319## Step 3
- step 4 The product of step 4 (50 mg, 0.11 mmol) was dissolved in dry acetonitrile (1.5 mL) and treated with copper oxide (2 mg, 0.014 mmol). The mixture was refluxed for 36 h under a stream of argon. At this time, it was diluted with ethyl acetate and quenched with 2N HCl. The layers were separated, and the organic was washed with brine and dried over MgSO 4 to afford 34 mg of Example 349 crystallized from ether/hexanes. MP 149° C.
- step 1 A suspension of the product of step 1 (1.42 g, 6.38 mmol) in methylene chloride was treated with oxalyl chloride (3.5 mL, 2M in CH 2 Cl 2 , 7.00 mmol) and one drop of DMF. The mixture was refluxed for 1 h under argon. At this time, the mixture was cooled to 0° C. and transferred via cannula into an ice cold solution of diazomethane (50 mL, 0.6M in Et 2 O, 30 mmol). The reaction mixture was allowed to stir at 0° C. for 1 h before it was quenched with HCl (30 mL, 1N in Et 2 O, 30 mmol).
- Example 349 The procedure was analogous to that of Example 349 except the product of step 2 was used instead of the corresponding product from the Example 349 preparation. MP 129°-130° C.
- Example 40 A one-necked, 10-mL, round-bottomed flask equipped with a rubber septum and an argon needle inlet containing 4 mL of triethylamine was charged with Example 40 (0.200 g, 0.401 mmol), trimethylsilylacetylene (0.063 mL, 0.050 g, 0.401 mmol), copper (I) iodide (0.764 g, 0.401 mmol), and trans-dichlorobis(triphenylphosphine)palladate (0.011 g, 0.016 mmol). The resulting mixture was stirred for 12 h at room temperature.
- reaction mixture was concentrated and the product isolated via column chromatography on 100 g of silica gel (20% ethyl acetate-hexanes with 0.5% acetic acid) afforded 0.163 g (87%) of coupling product as a white solid. MP 149° C.
- Example 15-9799 Column chromatography on 20 g of silica gel (20% ethyl acetate-hexanes with 0.5% acetic acid) afforded 0.104 g (88%) of Example 15-9799 as an off-white solid. MP 151° C.
- Step 1 from the above method for the preparation of Example 351 was used to prepare the following series of biphenyl products (TABLE XXIV) from Example 40 or Example 134 and the appropriate 1-alkyne.
- Step 1 from the above method for the preparation of Example 351 was used to prepare the propargyl methoxy acetylene starting material for the preparation of Example 353, Example 354, and Example 355.
- MP 151° C. MP 151° C.
- Example 253 (0.001 g), Example 354 (0.003 g), and Example 355 (0.001 g) were isolated via HPLC (SiO 2 column, 1% ethyl acetate-methylene chloride with 0.01% TFA).
- Step 2 from the above method for the preparation of Example 353, Example 354, Example 355 was used to prepare Example 356 and Example 357.
- Step 1 from the above method for the preparation of Example 351 was used to prepare the phenyl acetylene starting material for the preparation of Example 358, and Example 359. MP 154° C. ##STR331## Step 2--Preparation of Example 358 and Example 359
- Step 2 from the above method for the preparation of Example 353, Example 354, Example 355 was used to prepare Example 358 and Example 359.
- Example 360 (racemate) was separated into its most active (Example 361) and less active (Example 362) enantiomers on a Chiralcel" AS HPLC column using an ethanol/hexanes mixture as an eluent.
- a solution of the alcohol from Example 360, step 7 (0.039 g, 0.085 mmol), mono-methyl phthalate (0.032 g, 0.172 mmol), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide methiodide (0.033 g, 0.172 mmol) and N,N-dimethylaminopyridine (0.005 g, 0.04 mmol) in CH 2 Cl 2 (2 mL) was stirred at room temperature for 32 h. The reaction was diluted CH 2 Cl 2 and washed with water.
- Example 360-370 The above methods for the preparation of Example 360-370 were used to prepare the following series of biphenyl containing products (TABLE XXV).
- Example 393 (252 mg, 0.680 mmol) in 5 ml THF under argon. DBU was added (0.15 ml, 1.003 mmol) and allowed to stir for 24 h. The reaction mixture was diluted with CH 2 Cl 2 , then washed with 10% HCl, brine and dried over MgSO 4 . The concentrated crude material was crystallized with EtOAc-Hexane to give 117 mg Example 395. MP 197°-199° C. (dec). ##STR389##
- Example 396 was prepared from Example 394 using the procedure for the preparation of Example 395. MP 151°-152.5° C. ##STR390##
- Example 397 was crystallized from the crude product by using EtOAc-Hexane as solvent.
- Isomer Example 398 could be isolated from the mother liquors by HPLC. ##STR391##
- Example 400 could be prepared from Example 398 using the procedure for the preparation of Example 395. ##STR393##
- This compound was prepared by removing the acetate group of Example 399 with K 2 CO 3 --MeOH and subsequent hydrolysis of the methyl ester (formed during deblocking) with LiOH in MeOH--H 2 O.
- Example 402 was prepared from the product of step 2 using the procedure of Example 267, step 4.
- the alkene (5.00 g, 15 mmol) was dissolved in a mixture of 225 mL of dioxane, 60 mL of H 2 O and 15 mL of 2N H 2 SO 4 . Osmium tetraoxide was added and the solution was stirred for 10 min. NaIO 4 (13.00 g, 60 mmol) was added in small portions over 10 min. To this was added 15 mL of 2N H 2 SO 4 and the mixture was stirred for 5 h, as a white solid formed. To this slurry was added 250 mL of H 2 O to obtain a clear solution which was then extracted with Et 2 O (6 ⁇ 250 mL).
- Example 267 To a solution of Example 267 in dry THF (397 mL) was added a solution of tert-butyl trichloroacetimidate (23.0 mL, 86.0 mmoL) in cyclohexane (93 mL) followed by BF 3 .Et 2 O (1.76 mL, 14.3 mmol). The mixture was stirred at room temperature for 18 h after which NaHCO 3 ( ⁇ 5 g) was added to quench the reaction. The resulting slurry was filtered and the filtrate was concentrated under reduced pressure. The resulting crude solid was partitioned between CH 2 Cl 2 (500 mL) and water (500 mL).
- Step 3 To a mixture of the product of step 1 (0.20 g, 0.38 mmol) in abs. EtOH (3.8 mL) was added a 1M NaOH solution (0.8 mL, 0.8 mmol). The resulting slurry was stirred at room temperature for 6 h and concentrated under reduced pressure. The resulting residue was partitioned between EtOAc (10 mL) and water (10 mL). The aqueous layer was acidified with 10% aq HCl (10 mL) and extracted with EtOAc (3 ⁇ 10 mL). The organic phase was washed with a saturated NaCl solution (10 mL), dried (MgSO 4 ) and concentrated under reduced pressure to afford a white solid (0.13 g, 62%). TLC (10% MeOH/CH 2 Cl 2 ) R.sub. ⁇ 0.38. ##STR410## Step 3
- Imide from step 3 (1.56 g, 6.15 mmol), di-t-butyl 2-hydroxyethylmalonate from step 5 (1.60 g, 6.15 mmol), and PPh 3 (1.61 g, 6.15 mmol) were dissolved in dry THF (100 mL) and treated dropwise with diethyl azodicarboxylate (970 mL, 6.15 mmol). The solution was stirred at rt under argon for 6 d, then adsorbed onto silica.
- Example 405 The above methods for the preparation of Example 405 was used to prepare the following series of biphenyl products (TABLE XXVI).
- the imides were prepared from the commercially available hydroxyphthalic acids.
- a Imides for Examples 414-417 were prepared by the following method: t-Butyl phthalic anhydride (1.0 g, 4.9 mmol) and urea (0.60 g, 10.0 mmol) were heated to 150° C. to give a melt for 3 h. After cooling to rt, the crude solid was titurated from water twice and filtered. The solid was dissolved in ethyl acetate and dried over sodium sulfate. Solvent removed in vacuo to give a colorless solid (0.83 g, 83%). TLC R f 0.62 (25% EtOAc/75% Hexane).
- the imide for Example 418 was prepared by the following method: A solution of 4-bromo-1,8-naphthalic anhydride (2.50 g, 9.02 mmol) in NH 4 OH (100 mL) was heated to reflux at 70° C. for 3 h. The solution was cooled to rt, causing a tan solid to precipitate. The solid was filtered, washing with water. The crude product was recrystallized from HNO 3 (conc.) at reflux to give 4-bromo-1,8-naphthalimide (2.20 g, 89%) as near-colorless needles: TLC R f 0.25 (25% ethyl acetate:hexane).
- Steps 6-8 from Example 405 were followed to complete the synthesis of Example 419.
- Example 420 was prepared from the product of step 1 above according to the procedure of Example 405, step 8. MP 211°-215° (dec) °C. ##STR446##
- Example 421 was prepared according to the procedure of Example 420. MP 201 (dec) °C.
- Example 422 was prepared from the product of step 1 above according to the procedure of Example 405, step 8. MP 63°-67° C. ##STR449##
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US08/539,409 US5789434A (en) | 1994-11-15 | 1995-11-06 | Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors |
YU71295A YU71295A (sh) | 1994-11-15 | 1995-11-14 | Supstituisane 4-biarilbuterne ili 5-biaril pentanoinske kiseline i njihovi derivati kao matrični metaloproteazni inhibitori |
HR08/539,409A HRP950558A2 (en) | 1994-11-15 | 1995-11-14 | Substituted 4-biarylbutric or biarylpentanoic acids and derivatives as matrix metalloprotease inhibitors |
ARP950100171A AR002945A1 (es) | 1994-11-15 | 1995-11-14 | Acidos 4-biarilbutirico o 5-biarilpentanoico sustituidos y sus derivados como inhibidores de las metaloproteasas de matriz, composicion que los contiene, y metodos para la preparacion de dichos compuestos |
IL11599595A IL115995A0 (en) | 1994-11-15 | 1995-11-14 | Substituted 4-biarylbutyric or 5-biarylpentanoic acids and derivatives as matrix metalloprotease inhibitors |
TW84112045A TW413675B (en) | 1995-11-06 | 1995-11-14 | Substituted 4-biarylbutyric or 5-blarylpentanoic acids and derivatives matrix metalloprotease inhibitors |
TR95/01429A TR199501429A2 (tr) | 1994-11-15 | 1995-11-15 | Matriks metaloproteaz inhibitörlerinin yerine gecen 4-biarilpentanoik asitleri ve türevleri |
TNTNSN95117A TNSN95117A1 (fr) | 1994-11-15 | 1995-11-15 | Les acides substitues 4-biarylbutyrique ou 5-biarylpentanoique et derives en tant qu'inhibiteurs de metallprotease matricielle |
CO95053945A CO4650182A1 (es) | 1994-11-15 | 1995-11-15 | Acidos 4-biarilbutirico o 5-biarilpentanoico sustituidos y sus derivados como inhibidores de las metaloproteasas de la matriz |
US09/057,679 US6166082A (en) | 1994-11-15 | 1998-04-09 | Substituted 5-biarylpentanoic acids and derivatives as matrix metalloprotease inhibitors |
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US08/865,325 Expired - Lifetime US5886024A (en) | 1994-11-15 | 1997-05-28 | Thiophene-containing butonic acid derivatives as matrix metalloprotease inhibitors |
US08/864,666 Expired - Lifetime US5874473A (en) | 1994-11-15 | 1997-05-28 | Substituted cycloalkanecarboxylic acid derivatives as matrix metalloprotease inhibitors |
US08/866,798 Expired - Lifetime US5859047A (en) | 1994-11-15 | 1997-05-30 | Substituted 4-biarylbutyric acid derivatives as matrix metalloprotease inhibitors |
US08/866,679 Expired - Lifetime US5861427A (en) | 1994-11-15 | 1997-05-30 | Substituted 4-biarylbutyric acid derivatives as matrix metalloprotease inhibitors |
US08/866,778 Expired - Lifetime US5886043A (en) | 1994-11-15 | 1997-05-30 | Substituted 4-biarylbutyric acid derivatives as matrix metalloprotease inhibitors |
US08/865,639 Expired - Lifetime US5854277A (en) | 1994-11-15 | 1997-05-30 | Thiophenebutanoic acid derivatives as matrix metalloprotease inhibitors |
US08/866,680 Expired - Lifetime US5861428A (en) | 1994-11-15 | 1997-05-30 | Substituted 4-biarylbutyric acid derivatives as matrix metalloprotease inhibitors |
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US08/865,325 Expired - Lifetime US5886024A (en) | 1994-11-15 | 1997-05-28 | Thiophene-containing butonic acid derivatives as matrix metalloprotease inhibitors |
US08/864,666 Expired - Lifetime US5874473A (en) | 1994-11-15 | 1997-05-28 | Substituted cycloalkanecarboxylic acid derivatives as matrix metalloprotease inhibitors |
US08/866,798 Expired - Lifetime US5859047A (en) | 1994-11-15 | 1997-05-30 | Substituted 4-biarylbutyric acid derivatives as matrix metalloprotease inhibitors |
US08/866,679 Expired - Lifetime US5861427A (en) | 1994-11-15 | 1997-05-30 | Substituted 4-biarylbutyric acid derivatives as matrix metalloprotease inhibitors |
US08/866,778 Expired - Lifetime US5886043A (en) | 1994-11-15 | 1997-05-30 | Substituted 4-biarylbutyric acid derivatives as matrix metalloprotease inhibitors |
US08/865,639 Expired - Lifetime US5854277A (en) | 1994-11-15 | 1997-05-30 | Thiophenebutanoic acid derivatives as matrix metalloprotease inhibitors |
US08/866,680 Expired - Lifetime US5861428A (en) | 1994-11-15 | 1997-05-30 | Substituted 4-biarylbutyric acid derivatives as matrix metalloprotease inhibitors |
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