AR002945A1 - Acidos 4-biarilbutirico o 5-biarilpentanoico sustituidos y sus derivados como inhibidores de las metaloproteasas de matriz, composicion que los contiene, y metodos para la preparacion de dichos compuestos - Google Patents

Acidos 4-biarilbutirico o 5-biarilpentanoico sustituidos y sus derivados como inhibidores de las metaloproteasas de matriz, composicion que los contiene, y metodos para la preparacion de dichos compuestos

Info

Publication number
AR002945A1
AR002945A1 ARP950100171A AR10017195A AR002945A1 AR 002945 A1 AR002945 A1 AR 002945A1 AR P950100171 A ARP950100171 A AR P950100171A AR 10017195 A AR10017195 A AR 10017195A AR 002945 A1 AR002945 A1 AR 002945A1
Authority
AR
Argentina
Prior art keywords
group
derivatives
substituted
compounds
preparation
Prior art date
Application number
ARP950100171A
Other languages
English (en)
Original Assignee
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/539,409 external-priority patent/US5789434A/en
Application filed by Bayer Corp filed Critical Bayer Corp
Publication of AR002945A1 publication Critical patent/AR002945A1/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Acidos 4-biarilbutírico o 5-biarilpentanoico substituidos y sus derivados que tienen actividad inhibitoria de la metaloproteasa de la matriz,caracterizados por la fórmula (T)x A-B-D-E-G, donde A y B son anillos de arilo o heteroarilo;ca da T es un grupo de sustitución; x es 0, 1 ó 2; el grupo Drepresenta (II); el grupo E representa una cadena de dos o tres carbonos que lleva de uno a dos grupos de sustitución que son independientes o estánasociados en una formación de anillo,mos trándose las posibles estructuras en el texto y en las afirmaciones; y el grupo G representa -PO3H2, -M, y III en elque M represente -CO2H,-CON(R11)2 ó -CO2R12; y R13 representa cualquiera de las cadenas laterales de 19 aminoácidos no cíclicosque aparecen de forma natural,e incluye, por lo tanto, sales farmacéuticamente aceptables. También se relaciona con una composición que tiene actividad inhibitoria de la metaloproteasa de la matriz y un método para la preparación de dichoscompue stos.
ARP950100171A 1994-11-15 1995-11-14 Acidos 4-biarilbutirico o 5-biarilpentanoico sustituidos y sus derivados como inhibidores de las metaloproteasas de matriz, composicion que los contiene, y metodos para la preparacion de dichos compuestos AR002945A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33984694A 1994-11-15 1994-11-15
US08/539,409 US5789434A (en) 1994-11-15 1995-11-06 Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors

Publications (1)

Publication Number Publication Date
AR002945A1 true AR002945A1 (es) 1998-05-27

Family

ID=26991840

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP950100171A AR002945A1 (es) 1994-11-15 1995-11-14 Acidos 4-biarilbutirico o 5-biarilpentanoico sustituidos y sus derivados como inhibidores de las metaloproteasas de matriz, composicion que los contiene, y metodos para la preparacion de dichos compuestos

Country Status (5)

Country Link
US (1) US6166082A (es)
AR (1) AR002945A1 (es)
HR (1) HRP950558A2 (es)
IL (1) IL115995A0 (es)
TR (1) TR199501429A2 (es)

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* Cited by examiner, † Cited by third party
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CA2356053A1 (en) 1998-12-30 2000-07-13 Bayer Aktiengesellschaft Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors for the treatment of respiratory diseases
US7396810B1 (en) * 2000-08-14 2008-07-08 Oregon Health Sciences University Compositions and methods for treating cancer by modulating HER-2 and EGF receptors
US7625859B1 (en) * 2000-02-16 2009-12-01 Oregon Health & Science University HER-2 binding antagonists
US7393823B1 (en) 1999-01-20 2008-07-01 Oregon Health And Science University HER-2 binding antagonists
NZ520657A (en) * 2000-03-21 2004-11-26 Procter & Gamble Heterocyclic side chain containing, N-substituted metalloprotease inhibitors
JP2003528082A (ja) * 2000-03-21 2003-09-24 ザ プロクター アンド ギャンブル カンパニー ニフッ化酪酸メタロプロテアーゼ阻害物質
EP1265887A2 (en) * 2000-03-21 2002-12-18 The Procter & Gamble Company Carbocyclic side chain containing metalloprotease inhibitors
AU2001245863A1 (en) * 2000-03-21 2001-10-03 The Procter & Gamble Company Heterocyclic side chain containing metalloprotease inhibitors
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WO2006042002A2 (en) * 2004-10-05 2006-04-20 Oregon Health And Science University Compositions and methods for treating disease

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Also Published As

Publication number Publication date
TR199501429A2 (tr) 1996-06-21
IL115995A0 (en) 1996-01-31
US6166082A (en) 2000-12-26
HRP950558A2 (en) 1997-12-31

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