TR199501429A2 - Matriks metaloproteaz inhibitörlerinin yerine gecen 4-biarilpentanoik asitleri ve türevleri - Google Patents

Matriks metaloproteaz inhibitörlerinin yerine gecen 4-biarilpentanoik asitleri ve türevleri

Info

Publication number
TR199501429A2
TR199501429A2 TR95/01429A TR9501429A TR199501429A2 TR 199501429 A2 TR199501429 A2 TR 199501429A2 TR 95/01429 A TR95/01429 A TR 95/01429A TR 9501429 A TR9501429 A TR 9501429A TR 199501429 A2 TR199501429 A2 TR 199501429A2
Authority
TR
Turkey
Prior art keywords
derivatives
matrix metalloprotease
metalloprotease inhibitors
replace matrix
biarylpentanoic
Prior art date
Application number
TR95/01429A
Other languages
English (en)
Inventor
Harold Clinton Eugene Kluender
Guenter Hans Heinz Herber Benz
David Ross Brittelli
William Harrison Bullock
Kerry Jeanne Combs
Brian Richard Dixon
Stephan Schneider
Jill Elizabeth Wood
Michael Christopher Vanzandt
Donald John Wolanin
Scott M Wilhelm
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/539,409 external-priority patent/US5789434A/en
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of TR199501429A2 publication Critical patent/TR199501429A2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TR95/01429A 1994-11-15 1995-11-15 Matriks metaloproteaz inhibitörlerinin yerine gecen 4-biarilpentanoik asitleri ve türevleri TR199501429A2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33984694A 1994-11-15 1994-11-15
US08/539,409 US5789434A (en) 1994-11-15 1995-11-06 Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors

Publications (1)

Publication Number Publication Date
TR199501429A2 true TR199501429A2 (tr) 1996-06-21

Family

ID=26991840

Family Applications (1)

Application Number Title Priority Date Filing Date
TR95/01429A TR199501429A2 (tr) 1994-11-15 1995-11-15 Matriks metaloproteaz inhibitörlerinin yerine gecen 4-biarilpentanoik asitleri ve türevleri

Country Status (5)

Country Link
US (1) US6166082A (tr)
AR (1) AR002945A1 (tr)
HR (1) HRP950558A2 (tr)
IL (1) IL115995A0 (tr)
TR (1) TR199501429A2 (tr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010101325A (ko) 1998-12-30 2001-11-14 빌프리더 하이더 치환된 4-비아릴부티르산 유도체 및 5-비아릴펜탄산유도체의 호흡기 질환 치료용 매트릭스 메탈로프로테아제저해제로서의 용도
US7396810B1 (en) * 2000-08-14 2008-07-08 Oregon Health Sciences University Compositions and methods for treating cancer by modulating HER-2 and EGF receptors
US7393823B1 (en) 1999-01-20 2008-07-01 Oregon Health And Science University HER-2 binding antagonists
US7625859B1 (en) * 2000-02-16 2009-12-01 Oregon Health & Science University HER-2 binding antagonists
WO2001070682A2 (en) * 2000-03-21 2001-09-27 The Procter & Gamble Company Carbocyclic side chain containing metalloprotease inhibitors
MXPA02009311A (es) 2000-03-21 2003-03-12 Procter & Gamble Inhibidores de las metaloproteasas n-sustituidas que contienen cadenas laterales heterociclicas.
IL151250A0 (en) * 2000-03-21 2003-04-10 Procter & Gamble Difluorobutyric acid metalloprotease inhibitors
IL151124A0 (en) * 2000-03-21 2003-04-10 Procter & Gamble Heterocyclic side chain containing metalloprotease inhibitors
CA2511521C (en) 2002-12-30 2012-02-07 Angiotech International Ag Drug delivery from rapid gelling polymer composition
WO2005016864A1 (en) * 2003-07-29 2005-02-24 The Arizona Disease Control Research Commission Conjugated nitro alkene anticancer agents based on isoprenoid metabolism
CA2583230A1 (en) * 2004-10-05 2006-04-20 Oregon Health And Science University Compositions and methods for treating disease

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3182061A (en) * 1961-03-20 1965-05-04 Warner Lambert Pharmaceutical 5-[4-(p-hydroxyphenoxy)phenyl]-5-oxo-3-methylvaleric acid
BE667498A (tr) * 1964-07-28 1965-11-16
US3624142A (en) * 1964-09-10 1971-11-30 Merck & Co Inc Substituted biphenyl acetic acid derivatives
GB1121722A (en) * 1966-03-31 1968-07-31 Ici Ltd New carboxylic acid derivatives
US3707549A (en) * 1967-12-05 1972-12-26 Lilly Co Eli Alpha-substituted hydrocinnamic acids and derivatives thereof
US3754021A (en) * 1968-05-29 1973-08-21 Merck & Co Inc 4-keto-4-(3-chloro-4'-cyclohexyl)phenylbutyric acid and related compounds
US3876800A (en) * 1969-05-12 1975-04-08 Clin Midy Pharmaceutical compositions and methods for treating inflammation and pain
FR2104632A1 (en) * 1969-09-03 1972-04-21 Aries Robert Salicyloyloxy substd aralkanoic acids - analgesics, anticonvulsants antiinflammatories antipyretics, antirheumatics
US3917846A (en) * 1970-05-05 1975-11-04 William H Roher Inc Phenylacetic acids in reducing pain, fever and inflammation
US3867434A (en) * 1971-11-04 1975-02-18 Rorer Inc William H Phenyl butyric acids and derivatives thereof
US3784701A (en) * 1970-09-21 1974-01-08 American Cyanamid Co Compositions containing substituted benzoylpropionic acids and method of use to treat inflammation and pain
US4021479A (en) * 1971-03-17 1977-05-03 Boehringer Ingelheim Gmbh Derivatives of 4-(4-biphenylyl)-butyric acid
US3997589A (en) * 1971-03-17 1976-12-14 Boehringer Ingelheim Gmbh 4-(2'-Fluoro-4-biphenylylr-4-oxo-butyric acid and esters and salts thereof
US3749750A (en) * 1971-06-25 1973-07-31 American Home Prod Alkyl esters of substituted phenylsulfonyl alkanoic acids
BE787782A (fr) * 1971-08-20 1973-02-19 Thomae Gmbh Dr K Nouveaux 4-(4-biphenylyl)-butyramides
CS187460B2 (en) * 1974-03-01 1979-01-31 Merck Patent Gmbh Process for preparing new derivatives of phenylbutanole
US3962228A (en) * 1974-03-18 1976-06-08 American Home Products Corporation 3-benzoylpropionamido cephalosporanic derivatives
GB1498903A (en) * 1974-03-25 1978-01-25 Fabre Sa Pierre Aromatic keto-acids and their derivatives
FR2300551A2 (fr) * 1975-02-17 1976-09-10 Fabre Sa Pierre Nouveaux
AT336589B (de) * 1974-05-20 1977-05-10 Thomae Gmbh Dr K Verfahren zur herstellung von neuen biphenylderivaten
US4151302A (en) * 1975-06-28 1979-04-24 Merck Patent Gesellschaft Mit Beschrankter Haftung Araliphatic dihalogen compounds composition and method of use
US4168385A (en) * 1975-09-25 1979-09-18 American Cyanamid Company Hypolipemic phenylacetic acid derivatives
FR2378741A1 (fr) * 1977-02-01 1978-08-25 Fabre Sa Pierre Acides garyl goxo isovaleriques doues de proprietes antiphlogistiques et antalgiques
DE2964097D1 (en) * 1978-09-08 1982-12-30 Ici Plc Anti-arthritic hydroxyacetic acid derivatives, pharmaceutical compositions thereof, and processes for their manufacture
DE2854475A1 (de) * 1978-12-16 1980-07-03 Basf Ag Neue 3,4-diaza-bicyclo eckige klammer auf 4.1.0 eckige klammer zu hepten-(2)- one-(5), verfahren zu ihrer herstellung und diese verbindungen enthaltende therapeutische mittel
US4247466A (en) * 1979-07-05 1981-01-27 American Cyanamid Company Lactone metabolites of 3-(4-biphenylylcarbonyl)propionic acid
US4219668A (en) * 1979-07-05 1980-08-26 American Cyanamid Company 4-Hydroxy,4-biphenylbutyric acid
US4271191A (en) * 1979-12-19 1981-06-02 Pierre Fabre S.A. Method of treating hyperuricemia and gout
FR2503140A1 (fr) * 1981-03-31 1982-10-08 Fabre Sa Pierre Acides biphenyl-4 oxo-4 methylene-3 butyriques, leur procede de preparation et leur utilisation comme medicaments
US4577025A (en) * 1981-12-21 1986-03-18 Nissan Chemical Industries, Ltd. Method of preparing α-aromatic propionic acids and intermediates thereof
JPS58150563A (ja) * 1982-03-04 1983-09-07 Taisho Pharmaceut Co Ltd ３−ベンゾイル−２−メルカプトプロピオン酸誘導体
JPS6054356A (ja) * 1983-09-03 1985-03-28 Taisho Pharmaceut Co Ltd ３−ベンゾイル−２−メルカプトプロピオン酸誘導体
JPS60209539A (ja) * 1984-04-04 1985-10-22 Hitachi Ltd ネマチツク液晶化合物並びに液晶組成物
CS243570B1 (en) * 1984-08-31 1986-06-12 Miroslav Kuchar Omega-aryloxoalkane acids
JPS61200963A (ja) * 1985-02-28 1986-09-05 Taisho Pharmaceut Co Ltd ジフエニルスルフイド誘導体
JPS61200964A (ja) * 1985-02-28 1986-09-05 Taisho Pharmaceut Co Ltd ３−ベンゾイル−３−メルカプトプロピオン酸誘導体
DE3525284A1 (de) * 1985-07-16 1987-01-29 Boehringer Mannheim Gmbh Neue carbonsaeurederivate, verfahren zu ihrer herstellung, ihre verwendung sowie arzneimittel, die diese verbindungen enthalten
JPH0228579B2 (ja) * 1985-12-03 1990-06-25 Taisho Pharma Co Ltd Menekikinofuzenchiryozai
JPS6388168A (ja) * 1986-10-01 1988-04-19 Taisho Pharmaceut Co Ltd ３−ベンゾイルプロピオン酸誘導体
DK681287A (da) * 1986-12-24 1988-06-25 Beecham Group Plc Hidtil ukendte forbindelser
US5098613A (en) * 1987-01-12 1992-03-24 Eli Lilly And Company Anti-inflammatory agents
DE3700732A1 (de) * 1987-01-13 1988-07-21 Boehringer Mannheim Gmbh Neue carbonsaeurederivate, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
GB8814813D0 (en) * 1988-06-22 1988-07-27 Beecham Group Plc Novel compounds
CS276833B6 (en) * 1990-06-18 1992-08-12 Vyzk Ustav Farm Biochem Sp Functional derivatives of 4-(2,4-difluorobiphenylyl)-2-methyl -4- oxobutanoic acid
JPH04128262A (ja) * 1990-09-18 1992-04-28 Taisho Pharmaceut Co Ltd ３―ベンゾイルプロピオン酸誘導体
JP3031701B2 (ja) * 1990-11-27 2000-04-10 チッソ株式会社 ラクトン化合物および組成物
GB9027023D0 (en) * 1990-12-12 1991-01-30 Wellcome Found Anti-atherosclerotic aryl compounds
DE4102024A1 (de) * 1991-01-24 1992-07-30 Thomae Gmbh Dr K Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5250552A (en) * 1991-05-09 1993-10-05 Warner-Lambert Company 3-[thiazolidinone, oxazolidinone, imidazolidinone]-indoles as antiinflammatory agents
FR2679564A1 (fr) * 1991-07-23 1993-01-29 Inst Nat Sante Rech Med Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent.
US5273990A (en) * 1992-09-03 1993-12-28 Ciba-Geigy Corporation Phosphono substituted tetrazole derivatives
JPH05125029A (ja) * 1991-11-06 1993-05-21 Yamanouchi Pharmaceut Co Ltd 新規なアミド化合物又はその塩
PH30449A (en) * 1991-11-25 1997-05-28 Lilly Co Eli Substituted phenyl phenol leukotriene antagonists
SK280617B6 (sk) * 1992-01-16 2000-05-16 Hoechst Aktiengesellschaft Arylcykloalkylové deriváty, spôsob ich prípravy, f
US5217996A (en) * 1992-01-22 1993-06-08 Ciba-Geigy Corporation Biaryl substituted 4-amino-butyric acid amides
DE69309047T2 (de) * 1992-04-07 1997-09-11 British Biotech Pharm Hydroxamsäure enthaltende collagenase-inhibitoren und cytokinaktivitätsinhibitoren
WO1994007481A1 (en) * 1992-10-02 1994-04-14 Merck & Co., Inc. N-(mercaptoacyl)peptidyl derivatives as antidegenerative agents
JPH06234754A (ja) * 1993-02-10 1994-08-23 Dai Ichi Seiyaku Co Ltd 複素環式カルボン酸誘導体
US5565485A (en) * 1993-03-19 1996-10-15 Merck & Co., Inc. Biphenyl compounds useful or endothelin antagonists
US5536751A (en) * 1994-05-09 1996-07-16 The United States Of America As Represented By The Secretary Of The Army Pharmaceutical alpha-keto carboxylic acid compositions method of making and use thereof
US5789434A (en) * 1994-11-15 1998-08-04 Bayer Corporation Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors
US5648524A (en) * 1995-12-26 1997-07-15 Industrial Technology Research Institute Method for the preparation of 3-benzylthio-2-alkylpropionic acid and its derivatives
US5760276A (en) * 1997-03-06 1998-06-02 Allergan Aryl-and heteroarylcyclohexenyl substituted alkenes having retinoid agonist, antagonist or inverse agonist type biological activity
US6399612B1 (en) * 1997-10-06 2002-06-04 Warner-Lambert Company Heteroaryl butyric acids and their derivatives as inhibitors of matrix metalloproteinases

Also Published As

Publication number Publication date
US6166082A (en) 2000-12-26
IL115995A0 (en) 1996-01-31
HRP950558A2 (en) 1997-12-31
AR002945A1 (es) 1998-05-27

Similar Documents

Publication Publication Date Title
NO972307D0 (no) Matriksmetallproteaseinhibitorer
ATE217315T1 (de) Matrix metalloprotease-inhibitoren auf basis von phosphinsäuren
NO981938D0 (no) Proteaseinhibitorer
FI963597A0 (fi) Isoprenyylitransferaasi-inhibiittoreita
FI962315A (fi) Entsyymi-inhibiittorit
DK0873312T3 (da) Alfa-substituerede arylsulfonamidohydroxamsyrer som TNF-alfa- og matrix-metalloproteinaseinhibitorer
NO974403L (no) Reversible proteasehemmere
NO942064D0 (no) yminhibitorer
NO975742D0 (no) Reversible cysteinproteasehemmere
DE69718480D1 (de) Heterocyclische metalloprotease inhibitoren
DK0925303T3 (da) Phosphinsyreamider som matrixmetalloproteaseinhibitorer
DK0923561T3 (da) Heterocykliske metalloproteaseinhibitorer
ATE230275T1 (de) Angiogense-inhibitor
DK0934259T3 (da) Beta-sulfonamidohydroxamsyrer som matrixmetalloproteinase- og TACE-inhibitorer
NO995434L (no) Proteaseinhibitorer
NO995435D0 (no) Protease-inhibitorer
NO995268D0 (no) Proteaseinhibitorer
ID17792A (id) Penghambat penghambat metaloproreinase matriks
TR199501429A2 (tr) Matriks metaloproteaz inhibitörlerinin yerine gecen 4-biarilpentanoik asitleri ve türevleri
FI951101A (fi) 5-vinyyli- ja 5-etinyylikinoloni- ja -naftyridonikarboksyylihapot
EE9900180A (et) Asendatud 4-bifenüül-4-hüdroksübutaanhappe derivaadid metalloproteaasimaatriksi inhibiitoritena
NO20003506D0 (no) Matriksmetallproteaseinhibitorer
DE69523450T2 (de) Inhibitor
DE69431454D1 (de) Amylase Inhibitoren
CY2007006I2 (el) Αναστολεις συνθεσεις απολιποπρωτεϊνης-β