FI972062A - Substituoituja 4-biaryylivoi- tai 5-biaryylipentaanihappoja ja johdannaisia matriisimetalliproteaasi-inhibiittoreina - Google Patents
Substituoituja 4-biaryylivoi- tai 5-biaryylipentaanihappoja ja johdannaisia matriisimetalliproteaasi-inhibiittoreina Download PDFInfo
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- FI972062A FI972062A FI972062A FI972062A FI972062A FI 972062 A FI972062 A FI 972062A FI 972062 A FI972062 A FI 972062A FI 972062 A FI972062 A FI 972062A FI 972062 A FI972062 A FI 972062A
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- Prior art keywords
- biarylbutyric
- derivatives
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- delta
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- 239000011159 matrix material Substances 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- 239000003475 metalloproteinase inhibitor Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 102000005741 Metalloproteases Human genes 0.000 abstract 1
- 108010006035 Metalloproteases Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000004962 physiological condition Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
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- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4056—Esters of arylalkanephosphonic acids
- C07F9/4059—Compounds containing the structure (RY)2P(=X)-(CH2)n-C(=O)-(CH2)m-Ar, (X, Y = O, S, Se; n>=1, m>=0)
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US33984694A | 1994-11-15 | 1994-11-15 | |
PCT/US1995/014002 WO1996015096A1 (en) | 1994-11-15 | 1995-11-09 | Substituted 4-biarylbutyric or 5-biarylpentanoic acids and derivatives as matrix metalloprotease inhibitiors |
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Publication Number | Publication Date |
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FI972062A0 FI972062A0 (fi) | 1997-05-14 |
FI972062A true FI972062A (fi) | 1997-07-14 |
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FI972062A FI972062A (fi) | 1994-11-15 | 1997-05-14 | Substituoituja 4-biaryylivoi- tai 5-biaryylipentaanihappoja ja johdannaisia matriisimetalliproteaasi-inhibiittoreina |
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EP (1) | EP0790974B1 (fi) |
JP (1) | JPH10509146A (fi) |
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CN (1) | CN1121376C (fi) |
AT (1) | ATE222230T1 (fi) |
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BR (1) | BR9509686A (fi) |
CA (1) | CA2201863C (fi) |
CO (1) | CO4650182A1 (fi) |
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NO (1) | NO309523B1 (fi) |
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PT (1) | PT790974E (fi) |
RU (1) | RU2159761C2 (fi) |
SK (1) | SK51197A3 (fi) |
SV (1) | SV1995000074A (fi) |
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WO (1) | WO1996015096A1 (fi) |
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