HU78083A - Mátrix metalloproteáz inhibitor hatású helyettesített 4-diaril-vajsav és 5-diaril-pentánsav-származékok, előállításuk és a vegyületeket tartalmazó gyógyászati készítmények - Google Patents

Mátrix metalloproteáz inhibitor hatású helyettesített 4-diaril-vajsav és 5-diaril-pentánsav-származékok, előállításuk és a vegyületeket tartalmazó gyógyászati készítmények

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Publication number
HU78083A
HU78083A HU9800233A HU9800233A HU78083A HU 78083 A HU78083 A HU 78083A HU 9800233 A HU9800233 A HU 9800233A HU 9800233 A HU9800233 A HU 9800233A HU 78083 A HU78083 A HU 78083A
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HU
Hungary
Prior art keywords
compounds
pharmaceutical compositions
compositions containing
biarylentanoic
biarylbutyric
Prior art date
Application number
HU9800233A
Other languages
English (en)
Other versions
HU225939B1 (en
Inventor
Guenter Hans Heinz Herbert Benz
David Ross Brittelli
William Harrison Bullock
Kerry Jeanne Combs
Brian Richard Dixon
Harold Clinton Eugene Kluender
Stephan Schneider
Michael Christopher Vanzandt
Scott M. Wilhelm
Donald John Wolanin
Jill Elizabeth Wood
Original Assignee
Bayer Corporation
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Publication date
Application filed by Bayer Corporation filed Critical Bayer Corporation
Publication of HU78083A publication Critical patent/HU78083A/hu
Publication of HU225939B1 publication Critical patent/HU225939B1/hu

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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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HU9800233A 1994-11-15 1995-11-09 Substituted 4-biarylbutyric or 5-biarylentanoic acid derivatives as matrix metalloprotease inhibitiors, preparation thereof and pharmaceutical compositions containing these compounds HU225939B1 (en)

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ZA959647B (en) 1997-08-14
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US5854277A (en) 1998-12-29
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