MX2007010185A - Derivados de acido 5-fenil-pentanoico como inhibidores de metaloproteinasa de matriz para el tratamiento de asma y otras enfermedades. - Google Patents

Derivados de acido 5-fenil-pentanoico como inhibidores de metaloproteinasa de matriz para el tratamiento de asma y otras enfermedades.

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Publication number
MX2007010185A
MX2007010185A MX2007010185A MX2007010185A MX2007010185A MX 2007010185 A MX2007010185 A MX 2007010185A MX 2007010185 A MX2007010185 A MX 2007010185A MX 2007010185 A MX2007010185 A MX 2007010185A MX 2007010185 A MX2007010185 A MX 2007010185A
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MX
Mexico
Prior art keywords
sub
nhc
aralkyl
cycloalkyl
alkyl
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MX2007010185A
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English (en)
Inventor
Venkata P Palle
Viswajanani Jitendra Sattigeri
Manoj Kumar Khera
Sreedhara Rao Voleti
Abhijit Ray
Sunanda G Dastidar
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Ranbaxy Lab Ltd
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36591260&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2007010185(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ranbaxy Lab Ltd filed Critical Ranbaxy Lab Ltd
Publication of MX2007010185A publication Critical patent/MX2007010185A/es

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Abstract

La presente invencion se relaciona a compuestos que tienen la estructura de la Formula I: en donde n es un numero entero de 1 a 5; R1 es alquilo opcionalmente sustituido, alquenilo, alquinilo, cicloalquilo, arilo, heterociclilo, heteroarilo, aralquilo, alcoxi, ariloxi, alqueniloxi o alquiniloxi; R2 es alquenilo, alquinilo, arilo, heterociclilo, heteroarilo, cicloalquilo, NR4R5, -NHC(=Y)R4, -NHC(=Y))NR5RX, -NHC(=0)OR4, -NHSO2R4, C(=Y)NR4R5, C(=0)OR6 [en donde Y es oxigeno o azufre], OR5, -O(C=O)NR4R5, O-acilo, S(O)mR4, -SO2N(R4)2, ciano, amidino o guanidino [en donde R4 es alquilo, alquenilo, alquinilo, cicloalquilo, arilo, heterociclilo, heteroarilo, aralquilo, heteroarilalquilo, heterociclilalquilo o cicloalquilalquilo y m es un numero entero de 0-2; R5 es hidrogeno o R4; RX es R4 o -SO2N(R4)2 y R6 es hidrogeno, alquilo, cicloalquilo, aralquilo, heteroarilalquilo, heterociclilalquilo o cicloalquilalquilo]; R3 es hidrogeno, fluor, alquilo, cicloalquilalquilo o aralquilo; A es OH, OR4, -OC(=O)NR4R5, O-acilo, NH2, NR4R5, -NHC(=Y)R4, -NHC(=Y)NR5RX, -NHC(=O)OR4, -NHSO2R4, y a procesos para la sintesis de los mismos. La invencion tambien se relaciona a composiciones farmaceuticas que contienen los compuestos de la presente invencion, y metodos para tratar asma, artritis reumatoide, COPD, rinitis, osteoartritis, artritis psoriatica, psoriasis, fibrosis pulmonar, inflamacion pulmonar, sindrome de angustia respiratoria aguda, perodontitis, esclerosis multiple, gingivitis, aterosclerosis, proliferacion neointimal, que conduce a restenosis y falla del corazon isquemico, ataque apopletico, enfermedades renales, metastasis de tumor, y otros desordenes inflamatorios caracterizados por la sobre-expresion y sobre-activacion de una metaloproteinasa de matriz, usando los compuestos.
MX2007010185A 2005-02-22 2006-02-21 Derivados de acido 5-fenil-pentanoico como inhibidores de metaloproteinasa de matriz para el tratamiento de asma y otras enfermedades. MX2007010185A (es)

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PCT/IB2006/000349 WO2006090235A1 (en) 2005-02-22 2006-02-21 5-phenyl-pentanoic acid derivatives as matrix metalloproteinase inhibitors for the treatment of asthma and other diseases

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AU2006217615A1 (en) 2006-08-31
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CA2598518C (en) 2015-04-21
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GEP20094786B (en) 2009-09-25
PT1856063E (pt) 2012-04-12
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CA2598518A1 (en) 2006-08-31
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CY1112795T1 (el) 2016-02-10
EP1856063A1 (en) 2007-11-21
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US8710261B2 (en) 2014-04-29
SMP200700038B (it) 2007-09-26
AU2006217615B2 (en) 2012-07-12
SMAP200700038A (it) 2007-09-26
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KR101274309B1 (ko) 2013-06-13
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