CN101151255B - 5-苯基-戊酸衍生物作为基质金属蛋白酶抑制剂用于治疗哮喘及其它疾病 - Google Patents
5-苯基-戊酸衍生物作为基质金属蛋白酶抑制剂用于治疗哮喘及其它疾病 Download PDFInfo
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- CN101151255B CN101151255B CN2006800101326A CN200680010132A CN101151255B CN 101151255 B CN101151255 B CN 101151255B CN 2006800101326 A CN2006800101326 A CN 2006800101326A CN 200680010132 A CN200680010132 A CN 200680010132A CN 101151255 B CN101151255 B CN 101151255B
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- ethyl
- dihydro
- isoindole
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- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
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- C07D239/72—Quinazolines; Hydrogenated quinazolines
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- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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Abstract
Description
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IN380/DEL/2005 | 2005-02-22 | ||
IN380DE2005 | 2005-02-22 | ||
PCT/IB2006/000349 WO2006090235A1 (en) | 2005-02-22 | 2006-02-21 | 5-phenyl-pentanoic acid derivatives as matrix metalloproteinase inhibitors for the treatment of asthma and other diseases |
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CN101151255A CN101151255A (zh) | 2008-03-26 |
CN101151255B true CN101151255B (zh) | 2013-09-11 |
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CR (1) | CR9384A (zh) |
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GE (1) | GEP20094786B (zh) |
HK (1) | HK1115379A1 (zh) |
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NI (1) | NI200700220A (zh) |
NO (1) | NO20074648L (zh) |
NZ (1) | NZ560803A (zh) |
PL (1) | PL1856063T3 (zh) |
PT (1) | PT1856063E (zh) |
RS (2) | RS52232B (zh) |
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SM (1) | SMAP200700038A (zh) |
TN (1) | TNSN07320A1 (zh) |
UA (1) | UA98292C2 (zh) |
WO (1) | WO2006090235A1 (zh) |
ZA (1) | ZA200707560B (zh) |
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GB0321538D0 (en) * | 2003-09-13 | 2003-10-15 | Glaxo Group Ltd | Therapeutically useful compounds |
RS52232B (en) | 2005-02-22 | 2012-10-31 | Ranbaxy Laboratories Limited | 5-PHENYL-PENTANIC ACIDS DERIVATIVES AS MATRIX METALOPROTEINASE INHIBITORS FOR THE TREATMENT OF ASTHMA AND OTHER DISEASES |
MX2009001963A (es) | 2006-08-22 | 2009-03-30 | Ranbaxy Lab Ltd | Inhibidores de metaloproteinasa de matriz. |
AU2013200728B2 (en) * | 2006-08-22 | 2014-12-18 | Sun Pharmaceutical Industries Limited | Matrix metalloproteinase inhibitors |
FR2949463B1 (fr) * | 2009-08-26 | 2011-09-16 | Commissariat Energie Atomique | Inhibiteurs de mmp |
CN103119030A (zh) | 2010-07-30 | 2013-05-22 | 兰贝克赛实验室有限公司 | 基质金属蛋白酶抑制剂 |
SG188642A1 (en) | 2010-09-24 | 2013-05-31 | Ranbaxy Lab Ltd | Matrix metalloproteinase inhibitors |
CN103097892A (zh) * | 2010-11-23 | 2013-05-08 | 凯希特许有限公司 | 用于使用生物标志物进行伤口的诊断和治疗的装置和方法 |
ES2640485T3 (es) | 2011-08-12 | 2017-11-03 | Universitätsklinikum Freiburg | Uridina y análogos de uridina para el uso en el tratamiento de la enfermedad pulmonar obstructiva crónica |
GB201322512D0 (en) * | 2013-12-19 | 2014-02-05 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
EP3239143B1 (en) | 2014-12-24 | 2023-03-22 | LG Chem, Ltd. | Biaryl derivative as gpr120 agonist |
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CN1163604A (zh) * | 1994-11-15 | 1997-10-29 | 拜尔公司 | 作为基质金属蛋白酶抑制剂的取代的4-二芳基丁酸或5-二芳基戊酸及其衍生物 |
CN1337932A (zh) * | 1998-12-30 | 2002-02-27 | 拜尔公司 | 取代的4-联芳基丁酸和5-联芳基戊酸衍生物作为治疗呼吸疾病的基质金属蛋白酶抑制剂的用途 |
WO2004110974A1 (en) * | 2003-06-03 | 2004-12-23 | Glaxo Group Limited | Matrix metalloproteinase inhibitors |
WO2005026120A1 (en) * | 2003-09-13 | 2005-03-24 | Glaxo Group Limited | Matrix metalloproteinase inhibitors |
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US5109002A (en) | 1989-09-08 | 1992-04-28 | Du Pont Merck Pharmaceutical Company | Antipsychotic 1-cycloalkylpiperidines |
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WO1998009940A1 (en) | 1996-09-04 | 1998-03-12 | Warner-Lambert Company | Biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases |
MY117687A (en) * | 1996-10-31 | 2004-07-31 | Bayer Corp | Substituted 4-biphenyl-4-hydroxybutric acid derivatives as matrix metalloprotease inhibitors |
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AU4229499A (en) | 1998-07-30 | 2000-02-21 | Warner-Lambert Company | Tricyclic heteroaromatics and their derivatives as inhibitors of matrix metalloproteinases |
ITRM20010464A1 (it) | 2001-07-31 | 2003-01-31 | Sigma Tau Ind Farmaceuti | Derivati retinoidi ad attivita' antiangiogenica, antitumorale e pro-apoptotica. |
ATE432703T1 (de) | 2003-04-10 | 2009-06-15 | Ortho Mcneil Pharm Inc | Substituierte phenylacetamide und ihre anwendung als protease inhibitoren |
GB0314488D0 (en) | 2003-06-20 | 2003-07-23 | Glaxo Group Ltd | Therapeutically useful compounds |
RS52232B (en) | 2005-02-22 | 2012-10-31 | Ranbaxy Laboratories Limited | 5-PHENYL-PENTANIC ACIDS DERIVATIVES AS MATRIX METALOPROTEINASE INHIBITORS FOR THE TREATMENT OF ASTHMA AND OTHER DISEASES |
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2008
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2012
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CN1337932A (zh) * | 1998-12-30 | 2002-02-27 | 拜尔公司 | 取代的4-联芳基丁酸和5-联芳基戊酸衍生物作为治疗呼吸疾病的基质金属蛋白酶抑制剂的用途 |
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WO2005026120A1 (en) * | 2003-09-13 | 2005-03-24 | Glaxo Group Limited | Matrix metalloproteinase inhibitors |
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