UA98292C2 - Производные 5-фенилпентаноевой кислоты как ингибиторы матричной металлопротеиназы для лечения астмы и других заболеваний - Google Patents
Производные 5-фенилпентаноевой кислоты как ингибиторы матричной металлопротеиназы для лечения астмы и других заболеванийInfo
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- UA98292C2 UA98292C2 UAA200709535A UAA200709535A UA98292C2 UA 98292 C2 UA98292 C2 UA 98292C2 UA A200709535 A UAA200709535 A UA A200709535A UA A200709535 A UAA200709535 A UA A200709535A UA 98292 C2 UA98292 C2 UA 98292C2
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- aralkyl
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- Vascular Medicine (AREA)
Abstract
Данное изобретение касается соединений структурной Формулы I: где n равно целому числу от 1 до 5; R1 представляет собой необязательно замещенный алкил, алкенил, алкинил, циклоалкил, арил, гетероциклил, гетероарил, аралкил, алкокси, арилокси, алкенилокси или алкинилокси; R2 представляет собой алкенил, алкинил, арил, гетероциклил, гетероарил, циклоалкил, NR4R5, -NHC(=Y)R4, -NHC(=Y)NR5Rx, -NHC(=O)OR4, -NHSO2R4, C(=Y)NR4R5, C(=O)OR6 [де Y представляет собой кислород или серу], OR5, -O(C=O)NR4R5,О-ацил, S(O)mR4, -SO2N(R4)2, циано, амидино или гуанидино [где R4 представляет собой алкил, алкенил, алкинил, циклоалкил, арил, гетероциклил, гетероарил, аралкил, гетероарилалкил, гетероциклил алкил или циклоалкилалкил и m равно целому числу от 0 до 2; R5 представляет собой водород или R4; Rx представляет собой R4 или -SO2N(R4)2 и R6 представляет собой водород, алкил, циклоалкил, аралкил, герероарилалкил, гетероциклилалкил или циклоалкилалкил]; R3 представляет собой водород, фтор, алкил, циклоалкилалкил или аралкил; А представляет собой ОН, OR4,-OC(=O)NR4R5, О-ацил, NH2, NR4R5, -NHC(=Y)R4, -NHC(=Y)NR5Rx, -NHC(=O)OR4, -NHSO2R4, а также способов их синтеза. Данное изобретение также касается фармакологических композиций, которые содержат соединения за данным изобретением, и способов лечения астмы, ревматоидного артрита, ХОЗЛ, ринита, остеоартрита, псориатического артрита, псориаза, фиброза легких, воспаления легких, синдрома острого респираторного дистресса, периодонтита, рассеянного склероза, гингивита, атеросклероза, неоинтимальной пролиферации, что приводит к рестенозу и ишемической сердечной недостаточности, инсульта, заболеваний почек, опухолевых метастазов, а также других воспалительных расстройств, которые характеризуются чрезмерной экспрессией и чрезмерной активацией матричной металлопротеиназы, с использованием соединений.
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IN380DE2005 | 2005-02-22 | ||
PCT/IB2006/000349 WO2006090235A1 (en) | 2005-02-22 | 2006-02-21 | 5-phenyl-pentanoic acid derivatives as matrix metalloproteinase inhibitors for the treatment of asthma and other diseases |
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UAA200709535A UA98292C2 (ru) | 2005-02-22 | 2006-02-21 | Производные 5-фенилпентаноевой кислоты как ингибиторы матричной металлопротеиназы для лечения астмы и других заболеваний |
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US (1) | US8710261B2 (ru) |
EP (1) | EP1856063B1 (ru) |
JP (1) | JP4994247B2 (ru) |
KR (1) | KR101274309B1 (ru) |
CN (1) | CN101151255B (ru) |
AP (1) | AP2413A (ru) |
AT (1) | ATE542804T1 (ru) |
AU (1) | AU2006217615B2 (ru) |
BR (1) | BRPI0607469A2 (ru) |
CA (1) | CA2598518C (ru) |
CR (1) | CR9384A (ru) |
CY (1) | CY1112795T1 (ru) |
DK (1) | DK1856063T3 (ru) |
EA (1) | EA013539B1 (ru) |
ES (1) | ES2381681T3 (ru) |
GE (1) | GEP20094786B (ru) |
HK (1) | HK1115379A1 (ru) |
HR (1) | HRP20120250T1 (ru) |
IL (1) | IL185457A0 (ru) |
MA (1) | MA29312B1 (ru) |
MX (1) | MX2007010185A (ru) |
NI (1) | NI200700220A (ru) |
NO (1) | NO20074648L (ru) |
NZ (1) | NZ560803A (ru) |
PL (1) | PL1856063T3 (ru) |
PT (1) | PT1856063E (ru) |
RS (2) | RS20070374A (ru) |
SI (1) | SI1856063T1 (ru) |
SM (1) | SMAP200700038A (ru) |
TN (1) | TNSN07320A1 (ru) |
UA (1) | UA98292C2 (ru) |
WO (1) | WO2006090235A1 (ru) |
ZA (1) | ZA200707560B (ru) |
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GB0321538D0 (en) * | 2003-09-13 | 2003-10-15 | Glaxo Group Ltd | Therapeutically useful compounds |
EP1856063B1 (en) | 2005-02-22 | 2012-01-25 | Ranbaxy Laboratories Limited | 5-phenyl-pentanoic acid derivatives as matrix metalloproteinase inhibitors for the treatment of asthma and other diseases |
ES2397284T3 (es) | 2006-08-22 | 2013-03-06 | Ranbaxy Laboratories Limited | Proceso para preparar inhibidores de la metaloproteinasa de la matriz y auxiliares quirales para los mismos |
AU2013200728B2 (en) * | 2006-08-22 | 2014-12-18 | Sun Pharmaceutical Industries Limited | Matrix metalloproteinase inhibitors |
FR2949463B1 (fr) * | 2009-08-26 | 2011-09-16 | Commissariat Energie Atomique | Inhibiteurs de mmp |
CN103119030A (zh) | 2010-07-30 | 2013-05-22 | 兰贝克赛实验室有限公司 | 基质金属蛋白酶抑制剂 |
CN103228634A (zh) | 2010-09-24 | 2013-07-31 | 兰贝克赛实验室有限公司 | 基质金属蛋白酶抑制剂 |
WO2012071516A2 (en) * | 2010-11-23 | 2012-05-31 | Kci Licensing, Inc. | Devices and methods for the diagnosis and treatment of wounds using biomarkers |
EP2556832B1 (en) | 2011-08-12 | 2017-07-19 | Universitätsklinikum Freiburg | Uridine and uridine analogues for use in the treatment of chronic obstructive pulmonary disease |
GB201322512D0 (en) * | 2013-12-19 | 2014-02-05 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
AU2015367977B9 (en) * | 2014-12-24 | 2020-02-06 | Lg Chem, Ltd | Biaryl derivative as GPR120 agonist |
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US5109002A (en) | 1989-09-08 | 1992-04-28 | Du Pont Merck Pharmaceutical Company | Antipsychotic 1-cycloalkylpiperidines |
AU675689B2 (en) | 1992-12-01 | 1997-02-13 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5789434A (en) | 1994-11-15 | 1998-08-04 | Bayer Corporation | Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors |
US5516789A (en) | 1995-04-12 | 1996-05-14 | Abbott Laboratories | Lipoxygenase and cyclooxygenase inhibiting compounds |
EP0927156A1 (en) * | 1996-09-04 | 1999-07-07 | Warner-Lambert Company | Biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases |
MY117687A (en) * | 1996-10-31 | 2004-07-31 | Bayer Corp | Substituted 4-biphenyl-4-hydroxybutric acid derivatives as matrix metalloprotease inhibitors |
AU8020398A (en) | 1997-06-10 | 1998-12-30 | Unilever Plc | Method for enhancing the activity of an enzyme, bleach composition, detergent composition and process for inhibiting dye transfer |
US6037361A (en) * | 1998-03-09 | 2000-03-14 | Warner-Lambert Company | Fluorinated butyric acids and their derivatives as inhibitors of matrix metalloproteinases |
WO2000006560A1 (en) | 1998-07-30 | 2000-02-10 | Warner-Lambert Company | Tricyclic heteroaromatics and their derivatives as inhibitors of matrix metalloproteinases |
IL143594A0 (en) * | 1998-12-30 | 2002-04-21 | Bayer Ag | Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors for the treatment of respiratory diseases |
ITRM20010464A1 (it) | 2001-07-31 | 2003-01-31 | Sigma Tau Ind Farmaceuti | Derivati retinoidi ad attivita' antiangiogenica, antitumorale e pro-apoptotica. |
EP1613319B1 (en) | 2003-04-10 | 2009-06-03 | Ortho-McNeil Pharmaceuticals, Inc. | Substituted phenyl acetamides and their use as protease inhibitors |
GB0312654D0 (en) * | 2003-06-03 | 2003-07-09 | Glaxo Group Ltd | Therapeutically useful compounds |
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GB0321538D0 (en) | 2003-09-13 | 2003-10-15 | Glaxo Group Ltd | Therapeutically useful compounds |
EP1856063B1 (en) | 2005-02-22 | 2012-01-25 | Ranbaxy Laboratories Limited | 5-phenyl-pentanoic acid derivatives as matrix metalloproteinase inhibitors for the treatment of asthma and other diseases |
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