CN105829298A - 一种吡啶酮或嘧啶酮衍生物、及其制备方法和应用 - Google Patents
一种吡啶酮或嘧啶酮衍生物、及其制备方法和应用 Download PDFInfo
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- CN105829298A CN105829298A CN201580003159.1A CN201580003159A CN105829298A CN 105829298 A CN105829298 A CN 105829298A CN 201580003159 A CN201580003159 A CN 201580003159A CN 105829298 A CN105829298 A CN 105829298A
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- alkyl
- hydroxyl
- amino
- alkoxy
- carbocyclic ring
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- 150000008318 pyrimidones Chemical class 0.000 title abstract description 4
- 125000000623 heterocyclic group Chemical group 0.000 claims description 130
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- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 1
- 229960005080 warfarin Drugs 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
提供一种吡啶酮或嘧啶酮衍生物及其制备方法和应用。
Description
PCT国内申请，说明书已公开。
Claims (12)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410052381 | 2014-02-14 | ||
| CN2014100523818 | 2014-02-14 | ||
| PCT/CN2015/072236 WO2015120777A1 (zh) | 2014-02-14 | 2015-02-04 | 一种吡啶酮或嘧啶酮衍生物、及其制备方法和应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105829298A true CN105829298A (zh) | 2016-08-03 |
| CN105829298B CN105829298B (zh) | 2019-02-01 |
Family
ID=53799589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580003159.1A Expired - Fee Related CN105829298B (zh) | 2014-02-14 | 2015-02-04 | 一种吡啶酮或嘧啶酮衍生物、及其制备方法和应用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US10174020B2 (zh) |
| EP (1) | EP3138839B1 (zh) |
| CN (1) | CN105829298B (zh) |
| WO (1) | WO2015120777A1 (zh) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105658641A (zh) * | 2014-07-25 | 2016-06-08 | 江苏恒瑞医药股份有限公司 | 氮茚-酰胺类衍生物、其制备方法及其在医药上的应用 |
| WO2021197216A1 (zh) * | 2020-03-28 | 2021-10-07 | 成都肆零壹科技有限公司 | 一种连续化尼龙聚合方法 |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2712699T3 (es) | 2013-03-25 | 2019-05-14 | Bristol Myers Squibb Co | Tetrahidroisoquinolinas que contienen azoles sustituidos como inhibidores del factor XIa |
| NO2760821T3 (zh) | 2014-01-31 | 2018-03-10 | ||
| CN116987080A (zh) | 2014-01-31 | 2023-11-03 | 百时美施贵宝公司 | 作为因子xia抑制剂的具有杂环p2′基团的大环化合物 |
| JP6526796B2 (ja) | 2014-09-04 | 2019-06-05 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｆｘｉａ阻害剤であるジアミドマクロ環 |
| US10077265B2 (en) * | 2014-09-24 | 2018-09-18 | Bayer Pharma Aktiengesellschaft | Substituted oxopyridine derivatives |
| US10167280B2 (en) | 2014-09-24 | 2019-01-01 | Bayer Pharma Aktiengesellschaft | Substituted oxopyridine derivatives |
| EP3197880B1 (de) | 2014-09-24 | 2018-10-24 | Bayer Pharma Aktiengesellschaft | Substituierte oxopyridin-derivate mit anti-inflammatorischer und anti-thrombotischer wirkung |
| US9453018B2 (en) | 2014-10-01 | 2016-09-27 | Bristol-Myers Squibb Company | Pyrimidinones as factor XIa inhibitors |
| ES2927307T3 (es) * | 2014-12-10 | 2022-11-04 | Ono Pharmaceutical Co | Derivado de dihidroindolizinona |
| JO3703B1 (ar) * | 2015-07-09 | 2021-01-31 | Bayer Pharma AG | مشتقات أوكسوبيريدين مستبدلة |
| EP3371162B1 (en) | 2015-10-29 | 2022-01-26 | Merck Sharp & Dohme Corp. | Macrocyclic spirocarbamate derivatives as factor xia inhibitors, pharmaceutically acceptable compositions and their use |
| TW201808908A (zh) | 2016-08-22 | 2018-03-16 | 美商默沙東藥廠 | 因子XIa抑制劑 |
| CN113912586B (zh) * | 2016-08-31 | 2023-04-07 | 江苏恒瑞医药股份有限公司 | 氧代吡啶酰胺类衍生物、其制备方法及其在医药上的应用 |
| CN110193012B (zh) * | 2018-02-27 | 2022-02-08 | 江苏恒瑞医药股份有限公司 | 一种氧代吡啶酰胺类衍生物的药物组合物及其制备方法 |
| US11299462B2 (en) * | 2018-02-27 | 2022-04-12 | Jiangsu Hengrui Medicine Co., Ltd. | Crystal form of oxopicolinamide derivative and preparation method therefor |
| DK3774796T3 (da) | 2018-04-10 | 2022-07-18 | Bayer Pharma AG | Et substitueret oxopyridinderivat |
| US20220306602A1 (en) * | 2018-12-17 | 2022-09-29 | Bayer Aktiengesellschaft | Substituted oxopyridine derivatives for the treatment and/or prophylaxis of thrombotic or thromboembolic disorders and/or thrombotic or thromboembolic complications |
| CN113135929B (zh) * | 2020-01-17 | 2024-04-19 | 江西济民可信集团有限公司 | 呋喃并吡啶酮酰胺化合物及其制备方法和用途 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1222909A (zh) * | 1996-04-23 | 1999-07-14 | 麦克公司 | 吡嗪酮凝血酶抑制剂 |
| CN1575290A (zh) * | 2001-10-22 | 2005-02-02 | 卫材株式会社 | 嘧啶化合物以及含有该化合物的药物组合物 |
| WO2008079787A2 (en) * | 2006-12-20 | 2008-07-03 | Takeda San Diego, Inc. | Glucokinase activators |
| WO2013093484A1 (en) * | 2011-12-21 | 2013-06-27 | Ono Pharmaceutical Co., Ltd. | Pyridinone and pyrimidinone derivatives as factor xia inhibitors |
| CN105164122A (zh) * | 2013-03-28 | 2015-12-16 | 拜耳制药股份公司 | 取代的氧代吡啶衍生物及其在治疗心血管病症方面的用途 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014160592A2 (en) * | 2013-03-27 | 2014-10-02 | Merck Sharp & Dohme Corp. | FACTOR XIa INHIBITORS |
-
2015
- 2015-02-04 WO PCT/CN2015/072236 patent/WO2015120777A1/zh active Application Filing
- 2015-02-04 EP EP15748809.9A patent/EP3138839B1/en active Active
- 2015-02-04 CN CN201580003159.1A patent/CN105829298B/zh not_active Expired - Fee Related
-
2016
- 2016-10-14 US US15/293,815 patent/US10174020B2/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1222909A (zh) * | 1996-04-23 | 1999-07-14 | 麦克公司 | 吡嗪酮凝血酶抑制剂 |
| CN1575290A (zh) * | 2001-10-22 | 2005-02-02 | 卫材株式会社 | 嘧啶化合物以及含有该化合物的药物组合物 |
| WO2008079787A2 (en) * | 2006-12-20 | 2008-07-03 | Takeda San Diego, Inc. | Glucokinase activators |
| WO2013093484A1 (en) * | 2011-12-21 | 2013-06-27 | Ono Pharmaceutical Co., Ltd. | Pyridinone and pyrimidinone derivatives as factor xia inhibitors |
| CN105164122A (zh) * | 2013-03-28 | 2015-12-16 | 拜耳制药股份公司 | 取代的氧代吡啶衍生物及其在治疗心血管病症方面的用途 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105658641A (zh) * | 2014-07-25 | 2016-06-08 | 江苏恒瑞医药股份有限公司 | 氮茚-酰胺类衍生物、其制备方法及其在医药上的应用 |
| WO2021197216A1 (zh) * | 2020-03-28 | 2021-10-07 | 成都肆零壹科技有限公司 | 一种连续化尼龙聚合方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105829298B (zh) | 2019-02-01 |
| EP3138839B1 (en) | 2020-10-28 |
| EP3138839A1 (en) | 2017-03-08 |
| EP3138839A4 (en) | 2018-01-03 |
| WO2015120777A1 (zh) | 2015-08-20 |
| US20170029423A1 (en) | 2017-02-02 |
| US10174020B2 (en) | 2019-01-08 |
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