US20170103186A1 - Systems and methods for supporting patient use of a drug delivery device - Google Patents

Systems and methods for supporting patient use of a drug delivery device Download PDF

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Publication number
US20170103186A1
US20170103186A1 US15/315,954 US201515315954A US2017103186A1 US 20170103186 A1 US20170103186 A1 US 20170103186A1 US 201515315954 A US201515315954 A US 201515315954A US 2017103186 A1 US2017103186 A1 US 2017103186A1
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United States
Prior art keywords
patient
drug delivery
support group
delivery device
treatment regimen
Prior art date
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Abandoned
Application number
US15/315,954
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English (en)
Inventor
Adam B. McCullough
Ferry Tamtoro
Huaying Yang
Mark Ka Lai Lee
Desheng Yin
Scott R. Gibson
Donald Busby
Peter V. Shultz
Keith P. Kogler
Basel Hasan Taha
Jimmie L. Ward
Steven William Badelt
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Amgen Inc
Original Assignee
Amgen Inc
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53385997&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=US20170103186(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
Priority to US15/315,954 priority Critical patent/US20170103186A1/en
Assigned to AMGEN INC. reassignment AMGEN INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: Badelt, Steven William, LEE, MARK KA LAI, TAMTORO, FERRY, Kogler, Keith P., YANG, Huaying, Ward, Jimmie L., YIN, Desheng, TAHA, BASEL HASAN, BUSBY, DONALD, SHULTZ, Peter V., GIBSON, SCOTT R., MCCULLOUGH, ADAM B.
Publication of US20170103186A1 publication Critical patent/US20170103186A1/en
Abandoned legal-status Critical Current

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Definitions

  • the present disclosure generally concerns systems and methods for encouraging a patient to use a drug delivery device in accordance with a treatment regimen.
  • Drugs can be administered through the use of drug delivery devices, such as autoinjectors or on-body injectors or infusers. These devices may replace older delivery systems using the combination of a syringe and a vial containing the drug or medicament, or a pre-filled syringe. Autoinjectors and on-body injectors may be used to automate the injection and delivery or administration process, thereby simplifying the process for certain patient groups or sub-groups for which use of the syringe/vial combination or pre-filled syringe systems is disadvantageous, whether because of physiological or psychological impediments.
  • drug delivery devices such as autoinjectors or on-body injectors or infusers. These devices may replace older delivery systems using the combination of a syringe and a vial containing the drug or medicament, or a pre-filled syringe.
  • Autoinjectors and on-body injectors may be used to automate the injection and delivery or administration process, thereby simplifying
  • patients may experience challenges in being adherent or compliant with a treatment regimen. For example, certain patients may not perform the injections according to the treatment regimen, having forgotten to perform the injection at all. Other patients may perform the injections, but then be unable to remember whether they performed the injections because they become distracted before they are able to record that they did so. Some patients may elect not to perform the injections because of misunderstandings or miscommunications of when or how the medication will affect the patient's disease or symptoms, especially where the effects are not felt by the patient until a considerable portion of the treatment regimen has been performed.
  • Some patients may be more likely to follow a treatment regimen if they are provided with support and/or encouragement from others (e.g., a healthcare provider, a caregiver, a family member, a friend, another individual with a similar medical condition, etc.). However, the people who would potentially be willingly to provide such support and/or encouragement may be unaware that the patient has failed to follow the treatment regimen.
  • others e.g., a healthcare provider, a caregiver, a family member, a friend, another individual with a similar medical condition, etc.
  • the present disclosure sets forth various systems and methods to support patient use of a drug delivery device and facilitate compliance with a treatment regimen.
  • a social networking based method of providing a patient with support may include associating the patient with at least one support group.
  • the method may also include receiving data representative of at least one of a condition or an operational state of a drug delivery device associated with the patient.
  • the method may further include determining if the patient is compliant with a treatment regimen based on the condition or the operational state of the drug delivery device.
  • the method may include transmitting a communication to the at least one support group requesting the at least one support group to counsel the patient about the treatment regimen.
  • a support system for a patient includes a drug delivery system and an external computing device.
  • the drug delivery system may include a reservoir, a delivery cannula having a proximal end in fluid communication with the reservoir and a distal end to be received within the patient, one or more sensors, and a first communication module configured to transmit a report representative of at least one of a condition or an operational state of the drug delivery device.
  • the external computing device may include a second communication module configured to receive the report, a processor, and a memory coupled to the processor and configured to store non-transitory, computer-executable instructions.
  • the non-transitory, computer-executable instructions may cause the processor to: (i) associate the patient with the at least one support group; (ii) store, in the memory, a predefined criteria for determining compliance with a treatment regimen; (iii) compare the report with the predefined criteria to determine if the patient is compliant with the treatment regimen; and (iv) in response to a determination that the patient is not compliant with the treatment regimen, control the second communication module to transmit a communication to the at least one support group requesting the at least one support group to counsel the patient about the treatment regimen.
  • a non-transitory, computer-readable storage medium having computer-executable instructions that, when executed at one or more processors of a support system for a patient, cause the one or more processors to: (i) associate the patient with at least one support group; (ii) receive data representative of at least one of a condition or an operational state of a drug delivery device associated with the patient; (iii) determine if the patient is compliant with a treatment regimen based on the condition or the operational state of the drug delivery device; and (iv) in response to a determination that the patient is not compliant with the treatment regimen, transmit a communication to the at least one support group requesting the at least one support group to counsel the patient about the treatment regimen.
  • FIG. 1 is a schematic diagram of a drug delivery system according an embodiment of the disclosure in communication with one or more computing devices and one or more networks;
  • FIG. 2 is a block diagram of a method of operating the drug delivery system illustrated in FIG. 1 according to an embodiment of the disclosure
  • FIGS. 3A-3C is a block diagram of a method of operating the drug delivery system illustrated in FIG. 1 according to another embodiment of the disclosure;
  • FIG. 4 is a block diagram of a method of operating a computing device such as is illustrated in FIG. 1 according to an embodiment of the disclosure, the computing device in communication with a drug delivery system operating according to one of the methods disclosed herein, for example;
  • FIG. 5 is a schematic illustration of an embodiment of a system including a drug delivery device, a local computing device, and a remote computing device interconnected with communication links and networks;
  • FIG. 6 is a flow diagram of an embodiment of a method for supporting a paitent's use of a drug delivery device.
  • the present disclosure is directed to methods and systems for providing a patient under medical care with a social support network. More particularly, the present disclosure relates to monitoring patient use of a drug delivery device with sensors or other means and linking the patient to a support group who can encourage the patient to comply with a treatment regimen (e.g., a therapeutic regimen).
  • a treatment regimen e.g., a therapeutic regimen.
  • the systems and methods described herein may leverage the capabilities of social networking services (e.g., Facebook, Twitter, etc.) to identify a support group from which the patient is likely to take advice.
  • the presently disclosed methods and systems therefore may increase the likelihood of patient use of the drug delivery device in accordance with a treatment regimen.
  • the systems and methods may involve the determination of one or more states, which states may be determined through the use of one or more sensors in combination with one or more controllers.
  • the sensors may rely on mechanical, electrical or chemical sensing mechanisms, and the controllers may be mechanical, electrical or electro-mechanical.
  • the states may relate to the operation of the drug delivery device, or to the condition of the drug delivery device.
  • the system and methods may use the state determination to control the operation of the drug delivery device, and/or may communicate the state determination to other devices, such as third-party servers that may collect, process and/or further disseminate the state determinations received from the system including the drug delivery device, the one or more sensors, and the one or more controllers.
  • the systems and methods may communicate the state determination to local computing devices, such as a mobile computing device (e.g., cell phone).
  • a drug delivery system may include a drug delivery device having a reservoir (which may also be referred to as a primary container, e.g. a syringe, vial or cartridge).
  • the reservoir may contain a drug, which may also be referred to as a medication or a medicament.
  • the drug may be, but is not limited to various biologicals such as peptides, peptibodies, or antibodies.
  • the drug may be in a fluid or liquid form, although the disclosure is not limited to a particular state (e.g., no differentiation is intended between a solution, a gel, or a lyophilized product for example).
  • the drug delivery device also includes delivery cannula having a first end connected to or connectable in fluid communication with the reservoir and a second end to be inserted within a patient.
  • delivery cannula or “cannula” is hereby defined to mean a tube that can be inserted into the body for the delivery of fluid.
  • a cannula may include a rigid or semi-rigid needle or blunt cannula, or may be in a flexible form, by example and not by way of limitation.
  • the cannula may be integrated with the other elements of the drug delivery device, or the cannula may be separate from the other elements of the drug delivery until immediately prior to use.
  • the drug delivery device may further include an inserter to introduce the second end into the patient, although this is not required according to each embodiment of the disclosure.
  • the inserter may or may not be withdrawn back into the device, thereby leaving the cannula in a patient.
  • the device may be characterized as an autoinjector or an on-body injector or infuser (the reference to injector intended to include also a reference to an infuser, to the extent that a difference is suggested).
  • Autoinjectors may be single-use devices, administering a single dose during a single application of the device to the user's skin, although autoinjectors are not limited to only single-use devices—they may be multi-use devices as well.
  • On-body injectors may be multi-use devices, administering multiple doses during one or more applications of the device to the user's skin, although on-body devices may also be used as single-use devices.
  • Either autoinjectors or on-body injectors may have assemblies or sub-assemblies that are reusable, in that the assemblies may be used and re-used by refilling the reservoir, by removing an empty reservoir and replacing it with a filled reservoir, or by replacing the cannula, for example.
  • the system or method according to the disclosure will determine one or more states relative to the drug delivery device.
  • the system or method may determine if the drug delivery device is in one or more operational states (i.e., a state relating to the operation of the drug delivery device to deliver the drug to the patient).
  • operational states i.e., a state relating to the operation of the drug delivery device to deliver the drug to the patient.
  • a non-exhaustive list of the general operational states may include (i) packaged/ready for distribution; (ii) packaged/distributed; (iii) unpackaged/ready for administration; (iv) sterile barrier removed; (v) device applied; (vi) cannula injected (or inserted); (vii) drug delivery initiated; (viii) drug delivery completed; and (ix) device removed.
  • the system or method may determine specific operational states within each of the general operational states; for example, the system or method may determine if plunger has been moved from a first end of a bore (defining a drug reservoir) to a second end of the bore to determine if the drug delivery device is in the “drug delivery complete” state.
  • the system or method may determine if the drug delivery device is in one or more condition states (i.e., a state relating to the condition of the drug delivery device, not necessarily related to the operation of the drug delivery device to deliver the drug to the patient).
  • condition states may include (i) age (e.g., taken with respect to a manufacturing date or an expiration date); (ii) sterility/contamination; (iii) temperature; (iv) temperature history; and (iv) orientation.
  • the determination of a condition state may be considered as part of the determination of an operational state; for example, the determination of the temperature state may be considered as part of the determination of the “ready for administration” state.
  • the operational and condition states may be determined separately.
  • the sensors may be particular to a condition state to be determined: for example, a thermocouple disposed adjacent to the reservoir may be used to determine the temperature state of the drug delivery device.
  • the sensors may be particular to an operational state to be determined: for example, a switch may be coupled to a needle guard to determine when a needle cap has been removed to determine the “sterile barrier removed” operational state, the switch being open when the needle cap is disposed over the second end of the cannula and the switch being closed when the needle guard is not disposed over the second end of the cannula.
  • thermocouple may be used to determine the temperature condition state of the device (or more particularly, the drug), and/or the thermocouple may be used to determine the “ready for administration” operational state.
  • the system or method may use the determined states to control the operation of the drug delivery device.
  • the system may include a controller that is coupled to the sensor and may be coupled to one or more of the assemblies or subassemblies of the drug delivery device described above, or to one or more additional assemblies or subassemblies of the drug delivery device.
  • the controller may be adapted structurally or programmed (if electrical or electro-mechanical) to activate or to inhibit these assemblies or subassemblies in accordance with the determined states.
  • the drug delivery device may include a lockout that limits or completely inhibits the operation of the injector, and the controller may activate the lockout in a reversible fashion if the temperature state of the drug delivery device (and in particular, the drug in the reservoir) is below a threshold state.
  • the system or method may communicate the determined state(s) to another device or system, which communication may be performed in conjunction with use of the determined state(s) to control the operation of the drug delivery device.
  • the system or method may communicate the determined state(s) with a networked device using a communication link.
  • a networked device is intended to include any device that communicates with at least one other device over a communication link, and might include communication with a device such as mobile device (e.g., cell phone or mobile computing device) using a Bluetooth connection or a computing device using a Wi-Fi connection, for example.
  • the networked device may communicate the determined states to other computing devices remote from the drug delivery system over the network that includes the networked device such as a server.
  • the system communicates directly with the network (i.e., without an intermediate networked device—the system would be a networked device) or directly with a remote computing device such as a server (using, for example, a 3G antenna).
  • the state information communicated over network may then be used, for example, to determine if a patient is in compliance, or if a class of drug delivery devices is exhibiting a systemic malfunction.
  • the state information may be used in other manners as well.
  • the systems and methods may also include control of the drug delivery device according to information relating to the identity of the drug, the drug delivery device, or the user, and/or communication of this identity information.
  • Identity information relating to the drug may include a drug name, a drug concentration, dose information, a lot number or serial number, and a date of manufacture and/or expiration.
  • Identity information relating to the drug delivery device may include a device type (e.g., autoinjector, on-body injector), a lot number or serial number, and a date of manufacture.
  • Identity information relating to the user may include a patient name, demographic information, and patient subgroup information. This information may be referred to as “static” information, in contrast to the state information discussed above.
  • FIG. 1 illustrates a drug delivery system 100 according to an embodiment of the disclosure.
  • the drug delivery system 100 may be associated with a patient 102 , who may use the drug delivery system 100 , to inject a drug as part of a treatment regimen (e.g., a therapeutic regimen).
  • the drug delivery system 100 includes, but is not limited to, the drug delivery device describe below in more detail.
  • the drug delivery system 100 may communicate with a computing device 104 (e.g., a server) via one or more intermediate computing devices and/or one or more networks.
  • the server 104 may communicate with the drug delivery system 100 , the patient 102 , and one or more computing devices (with their associated parties) via one or more intermediate computing devices and/or one or more networks.
  • the server 104 may communicate directly with the drug delivery system 100 , using a 3G or 4G antenna, for example.
  • the drug delivery system 100 is illustrated as communicating with a mobile computing device 110 (e.g., a smartphone, a smartwatch, a smart wearable device, a tablet computer, etc.) via a first communication link 112 , and with a computing device 114 (e.g., a personal computer or a dedicated hub) via a second communication link 116 .
  • Both links 112 , 116 may operate according to, for example, a near field communication protocol, Bluetooth, and/or Bluetooth Low Energy.
  • the mobile computing device 110 may communicate with a cellular network 118 via a communication link 120
  • the other computing device 114 may communicate with a hard-wired network (e.g., local area network or wide area network) 122 via a communication link 124 .
  • These networks 118 , 122 may also communicate with the server 104 .
  • the networks 118 , 122 may facilitate communication between the server 104 and one or more parties associated with the patient 102 , such as his or her caregiver 130 , support giver 132 (e.g., a family member, a friend, individual using a similar drug and/or drug delivery device as the patient 102 ), a healthcare provider 134 , via their mobile computing devices (e.g., smartphones, smartwatches, smart wearable devices, tablet computers, etc.) and/or another computing devices.
  • the server 104 may also be in communication with one or more computing devices (e.g., servers) associated with one or more additional parties associated with the patient 102 .
  • a healthcare system server 140 a payment server 142 , a pharmacy server 144 , a distributor server 146 , and a governmental agency server 148 are illustrated in communication with the server 104 via the network 122 . It will also be recognized that the networks 118 , 122 may be in communication with each other.
  • the server 104 may be used to provide social networking based support for the user 102 of the drug delivery system 100 , as described below in more detail with reference to FIGS. 4 and 5 .
  • FIGS. 3A-3C illustrate a method 300 that may be viewed as illustrating some of the mixed operational and condition state monitoring that may occur in a method and system according to the disclosure.
  • the method 300 may also be viewed as illustrating how the one or more sensors may be used to determine the state changes described above.
  • the method 300 may be viewed as providing disclosure of operational and conditions state monitoring and communication of that information not illustrated in FIG. 2 .
  • the method 300 may begin with the drug delivery device in the package, and the method waits at block 302 until it is determined that the package has been opened.
  • the device may optionally be locked until such time as the system conducts one or more validations, verifications or checks to ensure that the device is ready to administer, the sterile barrier has been removed and/or the device has been (correctly) applied (see blocks 220 , 226 , 232 of method 220 in FIG. 2 ).
  • the method 300 may determine if the drug delivery device is adapted or programmed to carry out the validation, verification or check.
  • a determination may be made at block 304 if the drug delivery device is adapted or programmed to check the sterility of the drug delivery device; in particular, the validation or verification may be related to a sterile barrier disposed at the second end of the cannula. If the drug delivery device is adapted or programmed to perform the sterility check, the method 300 may proceed to block 306 , where it is determined if the sterile barrier is disposed over or about the second end of the cannula, for example.
  • the method may proceed to block 308 where the user is instructed to remove the barrier.
  • the method 300 may then determine at block 310 if the barrier has been removed. When it is determined that the barrier has been removed, a sterility timer may be started, the expiration of which may result in the drug delivery device being placed into or remaining in a locked state, preventing use of the drug delivery device.
  • the method 300 may proceed to block 312 , wherein the delivery device is locked (e.g., a lock or lock-out device is actuated) or the delivery device remains in a locked state if the device was previously locked.
  • the locking of the delivery device at block 312 may be irreversible.
  • the lock may be reversed once it is determined that the drug product (e.g., the drug product reservoir) has been replaced at block 314 . If the drug product is not replaced, or in those embodiments where the drug product cannot be replaced (i.e., the lock is irreversible), information regarding the failed sterility check may be communicated by the system.
  • the method 300 continues to block 316 .
  • a determination is made if the drug delivery device is capable of performing visual and/or environmental inspections. If the device is so adapted, the method proceeds to block 318 , wherein the determination is made if the visual inspection and/or environmental conditions are within desired thresholds.
  • the method may proceed to blocks 312 , 314 . If the determination is made that the visual inspection and/or environmental conditions are within desired thresholds, then the method 300 may proceed to block 320 .
  • the system may also communicate the information to local and/or remote devices. If the system is enabled to permit heating or cooling, then the method proceeds to block 336 , where the device may be locked or remain locked, heating or cooling may be initiated, and the user may be alerted. Whether passive or active heating or cooling (blocks 334 , 336 ), the method 300 may continue to block 338 , where delivery is delayed to provide time for the heating or cooling to occur before the method returns to block 330 . According to certain embodiments, the method 300 may terminate after block 330 (in case of excessive temperature, for example) and may communicate that information to local and/or remote devices.
  • the temperature check performed at block 330 may involve an evaluation of the temperature history of the drug product to determine the range and duration of temperatures experienced by the drug product in the past (e.g., during storage, distribution, etc.). If the temperature history of the drug product is unacceptable due to, for example, the drug product being exposed to elevated temperatures for several days during shipment, the controller 350 may lockout the drug delivery device 302 so that it cannot be used to deliver the drug product to a patient, and additionally, may control the communication module 352 to transmit a report to the local computing device 304 or the remote computing device 306 representative of the unacceptability of drug product's temperature history.
  • the controller may begin a timer that runs until the temperature falls back below the threshold temperature. If the duration of the timer exceeds a predefined time limit, the controller 350 may lockout the drug delivery device 302 and control the communication module 352 to transmit a report representative of the unacceptability of drug product's temperature history.
  • the method may continue to block 340 , where a determination is made if the device is enabled to determine that the device is properly positioned on or oriented relative to the patient. If the device is so adapted, then the method proceeds to block 342 , and a determination is made whether the device is properly disposed or oriented.
  • knowledge of the orientation of the device may be useful in providing a successful injection. For example, self-administration into the abdomen would most likely result in an orientation of an autoinjector axis approximately horizontal.
  • the method proceeds to block 344 , and the device may be locked and the user instructed to reposition or reorient the device.
  • the method 300 may then proceed to block 346 wherein a time delay is provided for the user to reposition the device before the method 300 returns to block 342 for a further determination relative to the position of the device.
  • the method may proceed to block 348 , and any locks or lockouts that may have been actuated are removed (or the device is unlocked).
  • the method 300 continues at block 350 , wherein a determination is made whether the system is enabled to determine if the delivery has been triggered. If the determination is made that the system is so adapted, then the method proceeds to block 352 , and a determination is made if the device has been activated or triggered. If the determination is made at block 352 that the device has not been triggered, then the method 300 may proceed to block 354 and the system may instruct the user to trigger the device. According to other embodiments, the drug delivery device may wait for a predetermined and/or preprogrammed time delay to occur before triggering the device automatically upon the completion of the time delay.
  • the method 300 may optionally determine if a timer has elapsed at block 355 to reduce the risk of contamination and infection, for example.
  • the timer may be started upon the determination that the barrier has been properly removed at block 310 (or may be started upon the determination that the barrier has been removed, according to still further embodiments), and if the method 300 does not determine that the device has been triggered within a certain amount of time from that event, the method 300 may return to block 312 , for example, as illustrated in FIGS. 3B and 3A .
  • the method proceeds to block 356 , where the user may be notified of the triggering of the device and/or the date, time and location of the delivery may be stored or recorded. Optionally, this information may also be communicated to local and/or remote devices in communication with the system. The method 300 then continued to FIG. 3C .
  • a needle shield e.g., needle shield 526 described below
  • a delivery cannula e.g., delivery cannula 514 described below
  • a plunger e.g., plunger 531 descrbied below
  • the method 300 proceeds to block 376 , where the system indicates to the user that the delivery is complete. Furthermore, the method 300 communicates information regarding the drug delivery, the drug delivery device, and the drug product to local and/or remote devices at block 378 . For example, the information may include that certain operational states occurred and the timing of the operational states. The method 300 may also verify that the device was correctly positioned throughout, where the system is enabled to make this determination. The method 300 may also pass to block 378 if the system is not enabled to determine if the administration of the drug product is complete, the assumption made that the drug delivery device having been determined to have passed through one or more of the preceding operational states necessarily leads to the conclusion that the delivery was completed.
  • the device need not determine each and every state or perform each and every action illustrated in FIG. 3A-3C . Rather, it will be recognized that one of ordinary skill in the art may omit or eliminate the determination of certain states or performance of certain actions, so as to result in a system that may control the device based on or communicate a subset of the states described.
  • the possible methods of operating one or more computing devices in communication with the drug delivery system is now discussed in the context of a method 400 illustrated in FIG. 4 .
  • the method 400 may be carried out by a single computing device, such as the server 104 illustrated in FIG. 1 , or the remote computing device 506 described below in connection with FIG. 5 .
  • the actions discussed with respect to FIG. 4 may be carried out by multiple computing devices, such as the mobile device 110 and/or the computing device 114 in conjunction with the server 104 illustrated in FIG. 1 , or the local computing device 504 and the remote computing device 506 illustrated in FIG. 5 .
  • the method 400 begins at block 402 with a determination as to whether a report has been received from the drug delivery system. If no report has been received, the method 400 waits at block 402 Once it is determined that a report has been received at block 402 , the method 400 proceeds to block 404 .
  • the report received from the drug delivery system is used to update one or more records.
  • the one or more computing devices adapted or programmed to carry out the method 400 may perform the actions of retrieving the one or more records from storage in one or more memory storage devices, writing the information received from the drug delivery device into the one or more records, and then storing the one or more records in the one or more memory storage devices.
  • the one or more memory storage devices may be part of the one or more computing devices, may be separate from the one or more computing devices, or may include one or more of the memory storage devices that are part of the one or more computing devices and one or more memory storage devices that are separate from the one or more computing devices (i.e., the record is stored at the computing device and in backup storage separate and possibly remote from the computing device).
  • the report may be used to update one or more records.
  • the patient record may be used, for example, to track the compliance of the individual patient (e.g., patient 102 ) with his or her regimen(s).
  • the drug delivery system record may be used to store information regarding the drug delivery system throughout the life of the drug delivery system.
  • the drug delivery system record may be accessed by the drug delivery system manufacturer or the drug provider for quality control purposes (e.g., to monitor individual instances of the drug delivery system for faults or failures attributable for to the drug delivery system, or to track the environmental condition histories of one or more drug delivery systems for patterns that may assist in determining improvements in the design, packaging, shipment or handling of the drug delivery systems).
  • quality control purposes e.g., to monitor individual instances of the drug delivery system for faults or failures attributable for to the drug delivery system, or to track the environmental condition histories of one or more drug delivery systems for patterns that may assist in determining improvements in the design, packaging, shipment or handling of the drug delivery systems.
  • the computing device adapted or programmed to carry out the method 400 may be adapted or programmed to carry out one or more actions based on the information in the report received from the drug delivery system.
  • the computing device may be adapted or programmed to carry out an action at block 406 .
  • This action may require not only the information received in the report and/or stored previously in the record updated at block 404 , but may require additional information such as from other patient records, drug system delivery records and/or drug records.
  • the determination may be made at block 408 that these other records need to be accessed, and the information retrieved at block 410 (e.g., by retrieving these other records from the patient, drug delivery system and drug databases and reading the information from these records once retrieved). The action may then be carried out at block 412 .
  • the one or more computing devices adapted or programmed to carry out the method 400 may be adapted or programmed to use the information received in the report to prepare a compliance history for the patient, which compliance history tracks uses of instances of the drug delivery system by the individual patient relative to his or her treatment regimen to determine how successful the patient has been in following the treatment regimen and which compliance history may be stored in the patient record.
  • the one or more computing devices may determine if a pharmacy should be contacted to order delivery of additional drug delivery devices for the individual patient, and may generate a communication to be sent to the pharmacy to order the delivery of additional drug delivery systems.
  • the one or more computing devices may determine if a reminder should be sent to the patient, via the mobile device 110 for example, to improve or support compliance with the individual patient's treatment regime, in which case the one or more computing devices may generate a communication to be sent to the patient or user of the device. Further, the one or more computing devices may determine that the operation of the drug delivery device should be modified because of a conditional state received from the drug delivery device, for example. For example, the one or more computing devices may determine that the drug delivery system should be locked to prevent its use because of the temperature history of the drug in the drug delivery system, for example.
  • the one or more computing devices may generate a communication, in the form of a signal for example, to be sent to the drug delivery system to lock the drug delivery device that is part of the drug delivery system.
  • a communication in the form of a signal for example, to be sent to the drug delivery system to lock the drug delivery device that is part of the drug delivery system.
  • the method 400 may proceed to blocks 414 , 416 , 418 where determinations are made if the computing device should make contact with other parties (block 414 ), interact with the patient (or user, if not the same as the patient) (block 416 ) or control the drug delivery device that is part of the drug delivery system (block 418 ).
  • the action taken at block 412 may involve the generation of communications or signals to be sent to third parties, such as the pharmacy, to the patient, or to the drug delivery device.
  • the one or more computing devices may carry out the actions of block 420 , 422 , 424 as dictated by the determinations made at blocks 414 , 416 , 418 .
  • the one or more computing devices may carry out the actions of blocks 420 , 422 , 424 even if it is determined that no action need be taken at block 406 .
  • the one or more computing devices may forward certain information to third parties 420 based solely on the receipt of the information in a report from the drug delivery device, such that there is no need to separately determine that an action need be taken in regard to the information received (i.e., the communication is automatically sent based on the fact that the information has been received, with the one or more computing devices acting as a repeater station for such information).
  • the receipt of information from the drug delivery device may also prompt communications to be sent to the patient/user or control signals to be sent to the drug delivery system without a separate determination that such action need be taken, the communication or control signal being sent simply because certain information and/or reports were received from the drug delivery system.
  • the method 400 may return to block 402 to await the next report.
  • the one or more computing devices may perform the actions of the method 400 in parallel for each of the reports received from different instances of the drug delivery system, or may perform this steps in sequence for each report. If performed in parallel, the one or more computing devices may determine if action is to be taken in regard to one report, while the one or more computing devices may be interacting with another patient in regard to the information contained in the report received from that patient.
  • the one or more computing devices carrying out the method 400 need not be adapted or programmed to carry out each of the actions described above according to every embodiment of the one or more computing devices.
  • one of the one or more computing devices may be adapted or programmed to update records for each patient and to determine if an interaction with that patient is required, while another of the one or more computing devices may be adapted or programmed to update records for each drug delivery device and to determine is a control signal should be sent to the drug delivery device, while another one of the one or more computing devices does not update any record, but is adapted or programmed to access, for example, a patient record and determine if the pharmacy needs to be contacted to order additional instances of the drug delivery system for the patient associated with the patient record accessed and to generate the communication if the order of additional instances of the system is required.
  • the methods 200 , 300 , and 400 touch only a fraction of the possible state and identity information that may be used to control and/or monitor the drug delivery device and that may be communicated between the drug delivery system and the one or more computing devices, as well as how that information is used by the drug delivery system and the one or more computing devices. Additional embodiments are possible according to the disclosure.
  • a non-limiting matrix of state and identity information may include the following:
  • This information may be used to control the drug delivery system or device, to be communicated to other computing devices, or otherwise to be used, and an exemplary listing of certain additional uses is included below.
  • the listing and additional comments below is not intended to supersede, but to augment the discussion above, and is intended to be non-limiting.
  • the drug delivery system or the one or more computing devices may make a determination regarding the authenticity of the drug and its compliance with manufacturing standards. Such a determination may be made by the drug delivery device at block 220 of method 200 or block 318 of method 300 , or by the one or more computing devices at block 406 of method 400 , for example. The determination may be made based on the temperature, shock or vibration exposure, and/or light exposure of the drug delivery device/drug (or a history of one or more of these conditions) and color and/or turbidity of the drug (as determined by an optical inspection). This determination may result in control of the drug delivery device to either lock or unlock the device, according to the determination made. See blocks 220 , 222 , 224 of method 220 , blocks 318 , 312 , 314 of method 300 , and blocks 406 - 412 and 418 , 424 of method 400 .
  • the drug delivery system or the one or more computing devices may make a determination whether the drug is appropriate for the patient. See block 220 of method 200 , block 322 of method 300 , and block 406 - 412 of method 400 .
  • the determination may be made based on one or more of the items of device of patient identity information listed above, and may also result in control of the drug delivery device to either lock or unlock the device, according to the determination made. See blocks 220 , 222 , 224 of method 220 , blocks 322 , 324 , 326 of method 300 , and blocks 406 - 412 and 418 , 424 of method 400 .
  • the drug delivery system or the one or more computing devices may make a determination whether the dose has been correctly administered. This determination may be carried out after determining that the drug is appropriate for the patient and/or that the drug is authentic (e.g., not counterfeit) and is in compliance with manufacturing standards. See the preceding paragraphs.
  • the determination whether the dose has been correctly administered may depend on one or more of the types of operational state information listed above. See blocks 220 - 260 of method 200 , and blocks 328 - 378 of method 300 . This information may be used to update the patient record, determine the patient compliance or therapy progress, and may prompt communication with the pharmacy regarding a refill, or with the payer (e.g., insurance company) to authorize payment for the drug delivery device. See blocks 404 - 414 of method 400 , and servers 142 , 144 of FIG. 1 .
  • the drug delivery system or the one or more computing devices may use the information to make a determination regarding the operational state of the drug delivery device, and to generate instructional messages to guide the user through the actions required for the proper use of the drug delivery device.
  • the determination may be based on any of the operational state information listed above, and the instructions generated may be dictated by the actions that need to be performed after the operational state that has just occurred. Implementation of interactive instructions that follow the changing states of the drug delivery device may help the user have confidence in administration of the drug.
  • the drug delivery system or the one or more computing devices may use the information to make a determination that the patient needs more medication (a refill). See blocks 406 - 412 of method 400 .
  • the determination may be based in part on the drug identity information, such as the prescribed treatment regime, and in part on the operational state information, such as where the drug delivery has been completed.
  • the one or more computing devices may generate a communication that is sent to the payer and/or pharmacy to request a prescription refill. See blocks 414 , 420 of method 400 .
  • the drug delivery system or the one or more computing devices may use the information to make a determination that the injection was not performed correctly. See blocks 406 - 412 of method 400 .
  • the determination may be based in part on operational state information, in comparison with information that may be collected and stored regarding conventional norms in operation.
  • a comparison between the determined, reported or received operational states may permit a determination to be made that the injection was not performed correctly. For example, the determination, reporting or receipt of operational state information indicating that the drug delivery is complete without operation state information indicating that device was triggered, that the device was applied to the patient, and/or that the cannula was inserted may indicate that the drug delivery device has failed to perform correctly, is faulty or was operated incorrectly.
  • the drug delivery system or the one or more computing devices may use the information to make a determination that patient's condition is improving.
  • the determination may be based in part on patient identity information, such as point-of-care diagnostics performed on the patient (e.g., blood glucose test or other testing) or self-analysis reporting, and in part on the determination, reporting or receipt of operational state information, such as where the drug delivery has been completed.
  • the determination may rely upon an overall trend as opposed to individual determinations or reports, as it is believed that data or reporting trends are usually more indicative of improvement in a patient's condition than the patient's condition as determined at individual instances for serious diseases.
  • the information gathered regarding the patient and the operational state of the drug delivery system/device may be combined with combined with therapy compliance history. This determination may result in individualized interventions to be generated, which interventions (such as encouraging messages and other forms of positive reinforcement) may increase persistence in therapy.
  • the drug delivery system or the one or more computing devices may use the information to make a determination of the time of day (or week, month, etc.) that the patient usually takes their medication. This determination may be based, in part, on the patient record in which time information is associated with operational state information, such as relates to the triggering of the drug delivery device or the completion of the drug delivery. This determination may also rely on device identity information, such as the prescribed treatment regimen. Based on this determination, the one or more computing devices may generate a reminder communication that is sent, for example, to the mobile device 110 to alert the patient that the time is approaching for them to administer their next dose.
  • the one or more computing devices may also generate a personalized intervention, such as a message of encouragement to be used as a positive reinforcement.
  • the drug delivery system or the one or more computing devices may use the information to make a determination where the patient usually takes their medication. This determination may be based, in part, on the patient record in which geographic position information is associated with operational state information, such as relates to the triggering of the drug delivery device or the completion of the drug delivery. This determination may also rely on device identity information, such as the prescribed treatment regimen. Based on this determination, the one or more computing devices may generate a reminder communication that is sent, for example, to the mobile device 110 to alert the patient that the time is approaching for them to administer their next dose when they are at or near the geographic location where the patient usually uses the drug delivery system.
  • the one or more computing devices may also generate a personalized intervention, such as a message of encouragement to be used as a positive reinforcement.
  • the determinations regarding the usual time and location of the use of the drug delivery device may be combined, and the one or more computing devices may generate a message only when the patient or user is at or near their usual location of use at or near the time they usually use the drug delivery device.
  • the drug delivery system or the one or more computing devices may use the information to make a determination that other people nearby are taking the same medication. See blocks 406 - 412 of method 400 .
  • This determination may be made based on the drug identity information and the patient identity information, in combination with the drug delivery system geographic location information.
  • This determination may prompt a communication with the patient (see blocks 416 , 422 of method 400 ) regarding local support networks of persons with similar conditions and/or taking similar drugs or medication to permit the patient to receive support and encouragement from such networks.
  • the determination may prompt a communication with the local support network(s) (see blocks 414 , 420 of method 400 ) requesting them to support and encourage to the patient.
  • the determination may prompt a personalized intervention communication to be sent to the patient (again, see blocks 416 , 422 of method 400 ).
  • the drug delivery system or the one or more computing devices may use the information to make a determination whether the patient is not in compliance with their treatment regimen. See blocks 406 - 412 of method 400 .
  • the determination may be based in part on the drug identification information, such as the prescribed treatment regime, in part on condition state information, such as the passage of time, and in part on the operational state information, such as where the drug delivery device is removed from the packaging but where no additional operational state information is determined, reported or received during the passage of time from the removal from packaging operational state.
  • the drug delivery system and/or the one or more computing devices may determine that an interaction with the patient should be generated, such as an alert may be displayed or sent to patient. See blocks 416 , 422 of method 400 .
  • the drug delivery system and/or one or more computing devices may determine that a communication should be generated to be displayed or sent to a healthcare provider, caregiver, support giver and/or payer to encourage adherence to the treatment regime. See blocks 414 , 420 of method 400 .
  • FIGS. 5 and 6 Described below with reference to FIGS. 5 and 6 are embodiments of a system and method for implementing the patient support network mentioned above in connection with FIG. 4 .
  • FIG. 5 illustrates an embodiment of a system 500 including a drug delivery device 502 , a local computing device 504 and a remote computing device 506 . While the system 500 includes both a local computing device 504 and a remote computing device 506 , not all embodiments according to this disclosure include both a local computing device 504 and a remote computing device 506 . Also, any one of the drug delivery device 502 , the local computing device 504 and the remote computing device 506 may be substituted for a corresponding element of FIG. 1 . For example, the drug delivery device 502 , the local computing device 504 , and the remote computing device 506 may be substituted for, respectively, the drug delivery system 100 , the mobile device 110 , and the server 104 of FIG. 1 .
  • the drug delivery device 502 may be in the form of an autoinjector, and thus is adapted for hand-held use and application against the skin of the patient.
  • the drug delivery device 502 includes a housing 510 in which are disposed assemblies or structures that introduce a delivery cannula into the patient, and that eject a drug or medicament from a reservoir 512 through the delivery cannula into the patient.
  • the same assemblies or structures that introduce the delivery cannula into the patient may also eject the drug or medicament from the reservoir through the delivery cannula into the patient.
  • the drug delivery device 502 may also include assemblies or structures that connect the delivery cannula to the reservoir, that withdraw the delivery cannula into the housing 510 through an opening in the housing 510 (not illustrated), or that deploy other structures that will prevent contact with the delivery cannula once the delivery cannula has been removed from the patient. Even additional assemblies and structures are possible.
  • the specific embodiment of the drug delivery device 502 discussed below is thus by way of example and not by way of limitation.
  • the drug delivery device 502 includes a reservoir 512 and a delivery cannula 514 having a first end 516 (e.g., a proximal end) that may be connected or connectable in fluid communication with the reservoir 512 and a second end 518 (e.g., a distal end) that may be inserted into a patient.
  • the delivery cannula 514 may be, for example, a rigid needle having a beveled edge that may be sized such that the second end 518 of the needle 514 is received under the skin so as to deliver a subcutaneous injection of the medicament within the reservoir 512 .
  • the first end 516 of the needle 514 may be disposed through a wall 520 of the reservoir 512 , and thus be connected in fluid communication with the reservoir 512 .
  • the first end 516 of the needle 514 may be disposed only partially through the wall 520 (which wall 520 may be a resalable septum or stopper, for example) such that the first end of the needle 514 may not be connected in fluid communication until the second end 518 of the needle 514 is inserted into the patient.
  • the first end 516 of the needle 514 may thus be described as connectable in fluid communication with the reservoir 512 , although it will be recognized that there are other mechanisms by which the first end 516 of the needle 514 may be connectable, but not connected, in fluid communication with the reservoir 512 .
  • the drug delivery device 502 includes a shield 522 (e.g., a needle shield) that may be deployed at least after the injection has been completed to limit access to the second end 518 of the needle 514 .
  • the shield 522 may have a biasing element 524 (such as a spring) that extends the shield 522 from the housing 510 such that a distal end 526 of the shield 522 extends beyond the second end 518 of the needle 514 except when the shield 522 is disposed against the skin and the insertion of the needle 514 is actuated.
  • the insertion of the needle 514 may be actuated according to certain embodiments of the drug delivery device 502 by disposing the distal end 526 of the shield 522 on or against the skin of the patient.
  • the drug delivery device 502 may also include a lock 528 (e.g., a ratchet) that is coupled to the shield 522 and configured to limit or prevent movement of the shield 522 relative to the housing 510 of the drug delivery device 502 such that the distal end 526 of the shield 522 extends from the housing 510 a sufficient distance to limit or prevent contact with the second end 518 of the needle 514 , for example, after the needle 514 has been removed or separated from the skin of the patient.
  • a lock 528 e.g., a ratchet
  • the lock 528 may be coupled to a controller (e.g., controller 550 described in more detail below) which can selectively activate or deactivate the lock 528 based on different types of information regarding the drug delivery device 502 , including operational state information, condition information, and/or identity information, in accordance with one or more of the methods described above.
  • a controller e.g., controller 550 described in more detail below
  • the lock 528 may be configured to limit or prevent movement of the needle shield 522 relative to the housing 510 .
  • the lock 528 may be configured to allow movement of the needle shield 522 relative to the housing 510 .
  • the drug delivery device 502 also includes at least one drive 530 that may be used to insert the second end 518 of the needle 514 into the skin of the patient, and to eject the drug or medicament from the reservoir 512 through the delivery cannula 514 into the patient.
  • the drive 530 may include one or more springs, according to certain embodiments.
  • the drive 530 may include a source of pressurized gas or a source of a material that undergoes a phase change, such that the escaping gas or phase changing material provides a motive force that may be applied to the reservoir 512 to eject the drug therefrom.
  • the drive 530 may include an electromechanical system, such as may include a motor for example, although such an electromechanical system may be more appropriate for the on-body autoinjector or infuser described above.
  • an electromechanical system such as may include a motor for example, although such an electromechanical system may be more appropriate for the on-body autoinjector or infuser described above.
  • Other embodiments of the drive 530 are also possible.
  • the drive 530 may be coupled to a plunger 531 and/or a stopper 532 (e.g., a wall) disposed in the reservoir 512 to move that stopper 532 in a distal direction toward the delivery cannula 514 .
  • the stopper 532 may be a stopper that is fixed to a distal end of the plunger 531 and received within a bore 534 .
  • the plunger 531 in conjunction with the drive 530 , may move the stopper 532 along a longitudinal axis of the drug delivery device 502 through the bore 534 from a proximal end of the bore 534 to a distal end of the bore 534 , and thereby eject the medicament from the reservoir 512 .
  • the drive 530 may also cooperate with the stopper 532 and/or the bore 534 to move the reservoir 512 relative to the housing 510 so as to move the second end 518 of the needle 514 relative to the housing 510 and into the patient. According to those embodiments wherein the drive 530 cooperates with the stopper 532 , this may occur before the first end 516 of the needle 514 is in fluid communication with the reservoir 512 .
  • the drive may include one component (e.g., first spring) that cooperates with the bore 534 to move the reservoir 512 and needle 514 relative to the housing 510 , and a second component (e.g., second spring) that cooperates with the stopper 532 to move the stopper 532 relative to the bore 534 .
  • first spring e.g., first spring
  • second spring e.g., second spring
  • the drug delivery device 502 may also include a lock 535 that is coupled to the plunger 531 and configured to limit or prevent movement of the plunger 531 relative to the housing 510 of the drug delivery device 502 so that the stopper 532 cannot be advanced to discharge the medicament from the reservoir 512 to the patient.
  • the lock 535 may be coupled to a controller (e.g., controller 550 described in more detail below) which can selectively activate or deactivate the lock 535 based on different types of information regarding the drug delivery device 502 , including operational state information, condition information, and/or identity information, in accordance with one or more of the methods described above.
  • the lock 535 When the lock 535 is activated by the controller 550 , the lock 535 may be configured to limit or prevent movement of the plunger 531 relative to the housing 510 . When the lock 535 is deactivated by the controller 550 , the lock 528 may be configured to allow movement of the plunger 531 relative to the housing 510 .
  • the drive 530 may be associated with an actuator 540 .
  • the actuator 540 may activate the drive 530 to cause the drive 530 to insert the needle 514 and eject the drug from the reservoir 512 through the needle 514 into the patient.
  • the actuator 540 may, according to certain embodiments, be the needle shield 522 , as explained above. According to other embodiments, such as the one illustrated in FIG. 5 , the actuator 540 may be a button that may be manually depressed by the user or patient once the drug delivery device 502 is placed disposed on or against the patient's skin.
  • a lock 541 may be coupled to the actuator 540 and configured to limit or prevent movement of the actuator 540 so that the actuator 540 cannot be used to activate the drive 530 .
  • the lock 541 may be coupled to a controller (e.g., controller 550 described in more detail below) which can selectively activate or deactivate the lock 541 based on different types of information regarding the drug delivery device 502 , including operational state information, condition information, and/or identity information, in accordance with one or more of the methods described above.
  • a controller e.g., controller 550 described in more detail below
  • the lock 541 may be configured to limit or prevent movement of the actuator 540 relative to the housing 510 .
  • the lock 541 may be configured to allow movement of the actuator 540 relative to the housing 510 .
  • the drug delivery device 502 may also include a removable sterile barrier 544 that is disposed about one or more of a distal end of the housing 510 , the needle shield 522 , and the second end 518 of the delivery cannula 514 .
  • the removable sterile barrier 544 may be removably attached to the distal end of the housing 510 as shown in FIG. 5 .
  • the removable sterile barrier 544 may form an interference or snap fit with the distal end of the housing 510 . A frictional force associated with the interference or snap fit may be overcome by manually pulling the removable sterile barrier 544 in a direction away from a housing 510 .
  • the removable sterile barrier 544 when attached to the drug delivery device 502 , may reduce the risk of contamination of the delivery cannula 514 and other elements disposed within the drug delivery device 502 .
  • the drug delivery device 502 may include a heating element 546 coupled to the exterior of the reservoir 512 and configured to warm the medicament inside the reservoir 512 through, for example, conductive heating.
  • the heating element 546 may be coupled to the controller 550 so that the controller 550 can selectively activate or deactivate the heating element 546 based on different types of information regarding the drug delivery device 502 , including operational state information, condition information, and/or identity information, in accordance with one or more of the methods described above.
  • the heating element 546 may include an electrically conductive coil that is wrapped around the exterior of the reservoir 512 .
  • a cooling element (not illustrated) may be coupled to the reservoir 512 and controllable by the controller 550 in a manner similar to the heating element 546 .
  • the drug delivery device 502 may also include an output unit 547 coupled to the housing 510 and configured to notify the patient or user of information related to the drug delivery device 502 .
  • the output unit 547 may be coupled to the controller 550 so that the controller 550 can selectively activate or deactivate the output unit 547 based on different types of information regarding the drug delivery device 502 , including operational state information, condition information, and/or identity information, in accordance with one or more of the methods described above.
  • the output unit 547 may be any device suitable for conveying information to the patient or user including a display (e.g., a liquid crystal display), a touchscreen, a light (e.g., a light emitting diode), a vibrator (e.g., an electro-mechanical vibrating element), a speaker, and/or an alarm, among other devices.
  • a display e.g., a liquid crystal display
  • a touchscreen e.g., a liquid crystal display
  • a light e.g., a light emitting diode
  • a vibrator e.g., an electro-mechanical vibrating element
  • speaker e.g., a speaker, and/or an alarm, among other devices.
  • the drug delivery device 502 may also include an input unit 548 coupled to the housing 510 and configured to allow a user or patient to input information (e.g., password information) to be used by the controller 550 .
  • the input unit 548 , the output unit 547 , and even the fingerprint sensor 565 may be a single device such as a touchscreen.
  • the input unit 548 may be a separate device from the output unit 547 such as a keyboard or button.
  • the reservoir 512 , the biasing element 524 , the locks 528 , 535 , 541 , the plunger 531 , the stopper 532 , and the drive 530 , and the heating element 546 are disposed within the housing 510 , along with at least part of the delivery cannula 514 .
  • a controller 550 Also disposed within the housing 510 is a controller 550 , a communication module 552 (e.g., a wireless transmitter), and at least one sensor or switch.
  • a temperature sensor 560 e.g., a temperature sensor 560 , a skin sensor 562 , at least one orientation sensor 564 , and a fingerprint sensor 565 .
  • the sensors 560 , 562 , 564 , and 565 may each generate sensor data (e.g., raw or unprocessed data) related to a respective measured property or aspect of the drug delivery device 502 .
  • the sensor data may be representative of at least one of a condition or operational state of the drug delivery device 502 .
  • the drug delivery device 502 includes a switch 566 .
  • the controller 550 is coupled to the communication module 552 , the locks 528 , 535 , 541 , the sensors 560 , 562 , 564 , 565 , the heating element 546 , the fingerprint sensor 565 , the output unit 547 , the input unit 548 , and the switch 566 .
  • the controller 550 may be configured to process the sensor data generated by the sensors 560 , 562 , 564 , and 565 to determine a condition and/or operational state of the drug delivery device 502 .
  • the controller 550 , the communication module 552 , one or more of the sensors 560 , 562 , 564 , 565 and the switch 566 may be packaged together as a single module, or each component may be fabricated separately and coupled once the components are disposed within the housing 510 .
  • each electrical component may be integrated into the structure of the device 502 associated with that electrical component (e.g., the sensors 562 and 564 may be integrated into the shield 522 ).
  • the controller 550 , the communication module 552 , one or more of the sensors 560 , 562 , 564 , 565 , and/or the switch 566 may be packaged together inside the removable sterile barrier 544
  • the controller 550 may include at least one processor 570 (e.g., a microprocessor) and a memory 572 (e.g., a random access memory (RAM), a non-volatile memory such as a hard disk, a flash memory, a removable memory, a non-removable memory, etc.).
  • the controller 550 may also include or be coupled to a power supply, e.g. a battery.
  • the processor 570 may be programmed to carry out the actions that the controller 550 is adapted to perform and the memory 572 may include one or more tangible non-transitory readable memories having executable, computer-readable, non-transitory instructions stored thereon, which instructions when executed by the at least one processor 570 may cause the at least one processor 570 to carry out the actions that the controller 550 is adapted to perform.
  • the controller 550 may include other circuitry that carries out the actions that the controller is adapted to perform.
  • the memory 572 may store the identity information discussed above.
  • the identity information may be stored in the memory 572 prior to the start of execution of any of the methods discussed above.
  • the identity information may include, by way of example and not by way of limitation, a unique identifier, the name of the drug, the dosage, an expiration date, and information regarding the identity of the patient for whom the drug was prescribed. With this information, the controller 550 or a local computing device (e.g., a smartphone) may make a determination regarding the patient that is about to receive the drug, and provide appropriate informational and/or instructional prompts.
  • the identity information may be contained in a QR code label or RFID tag associated with the drug delivery device 502 .
  • the communication module 552 may be any of a number of different communication modules used to communicate with a local computing device (e.g., a smartphone) and/or a remote computing device (e.g., a server operated by the device manufacturer).
  • the communication module 552 may be a Bluetooth and/or Bluetooth Low Energy module that is on-board with the controller 550 .
  • the communication module 552 is used to transmit information from the drug delivery device 502 to the local computing device 504 .
  • other wireless protocols may be used by the communication module 552 , such as radio-frequency identification (RFID), Zigbee, Wi-Fi, near field communication (NFC), and others.
  • RFID radio-frequency identification
  • NFC near field communication
  • the communication may be sent along a hardwired connection, rather than using the electromagnetic (EM) spectrum.
  • EM electromagnetic
  • a communication transmitted and/or received between the module 552 , the local computing device, and/or the remote computing device may be in the form of a hardwired signal or EM signal or a
  • the temperature sensor 560 may be disposed proximate to the reservoir 512 so that the temperature of the drug in the reservoir 512 may be determined. Alternatively, the temperature sensor 560 may simply be disposed in the housing 510 , so that an approximate temperature of the drug in the reservoir 512 and of the drug delivery device 502 generally may be determined. According to an embodiment, the temperature sensor 560 may be an on-board temperature sensor 560 attached to the processor 570 .
  • the skin sensor 562 may be attached to or associated with the shield 522 to determine when the drug delivery device 502 is disposed on or against the patient's skin.
  • the skin sensor 562 is a pressure sensor.
  • the skin sensor 562 may be a capacitance sensor, resistance sensor, or inductance sensor.
  • the skin sensor 562 or the switch 566 (which is attached to or associated with the actuator 540 ) may be used to determine when the drug delivery device 502 is activated or actuated, depending on the design and operation of the drug delivery device 502 that is used to actuate the drive 530 , in accordance with the discussion above.
  • a signal from the skin sensor 560 is used to determine that the drug delivery device 502 has been activated even when the shield 522 is not used as the actual actuator, the underlying assumption being that the movement of the shield 522 is necessarily related to the actuation of the device 502 .
  • the orientation sensors 564 may be associated with the shield 522 (or that portion of the housing 510 adjacent the shield 522 ) and the controller 550 (which may be, as illustrated, disposed at the other end of the drug delivery device 502 or the housing 510 from the shield 522 ).
  • the orientation sensors 564 may be magnetometers, for example.
  • the orientation sensor 564 associated with the controller 550 may be an on-board magnetometer.
  • the orientation sensors 564 may be used to determine the orientation of the drug delivery device 502 (in particular, the housing 510 ) relative to the injection site (or more particularly, relative to the placement of the drug delivery device 502 on or against the patient's skin).
  • the local computing device 504 may be in the form of at least one computing device including at least one processor 620 (e.g., microprocessor) and a memory 622 (e.g., a random access memory (RAM), a non-volatile memory such as a hard disk, a flash memory, a removable memory, a non-removable memory, etc.).
  • the at least one processor 620 and the memory 622 may be incorporated into a controller 623 of the local computing device 504 and/or may be configured separately.
  • the remote computing device 506 may be in the form of at least one computing device including at least one processor 624 (e.g., microprocessor) and memory 626 (e.g., a random access memory (RAM), a non-volatile memory such as a hard disk, a flash memory, a removable memory, a non-removable memory, etc.).
  • the at least one processor 624 and the memory 626 may be incorporated into a controller 627 of the local computing device 504 and/or may be configured separately.
  • the processors 620 , 624 may be programmed to carry out actions described below relative to the method of FIG.
  • the memories 622 , 626 may include one or more tangible, non-transitory computer-readable memories having computer-executable instructions stored thereon, which instructions when executed by the processors 622 , 624 may cause the processors 622 , 624 to carry out the actions described below relative to the method of FIG. 6 .
  • the computer-executable instructions may be included in a software application (e.g., a mobile software application, also commonly referred to as a “mobile app”) stored in the memory 622 of the local computing device 504 .
  • the software application may be installed on local computing device 504 as one or more downloaded files, such as an executable package installation file downloaded from a suitable application store via a connection to the Internet. Examples of package download files may include downloads via the iTunes store, the Google Play Store, the Windows Phone Store, downloading a package installation file from another computing device, etc.
  • the software application may be developed for a mobile operating system such as AndroidTM or iOS®, developed by Google and Apple, respectively.
  • the application may be initiated by a user selecting an icon shown on a home screen of a display 632 (e.g., a touchscreen) of the local computing device 504 .
  • Various displays including messages received from a support group, may be generated in the application and displayed to a user and/or patient via the display 632 of the local computing device 504 .
  • the local computing device 504 may carry out the actions of FIG. 6 independent of the remote computing device 506 . According to other embodiments, the local computing device 504 may carry out certain of the actions of FIG. 6 , while the remote computing device 506 carries out other of the actions of FIG. 6 .
  • the processor(s) 620 may control components of the local computing device 504 permitting communication with the controller 550 and/or the user, but may not make the determinations as to the content of those communications, the determinations relative to the content of the communications being made at the remote computing device 506 .
  • the local computing device 504 is a mobile computing device (e.g., a smartphone, a smartwatch, a smart wearable device, a personal computer, a laptop computer, or a tablet computer, etc.) while the remote computing device 506 is a server.
  • the local computing device 504 can include generally any computing device capable of processing data and being synched to and in communication with the drug delivery device 502 such as, for example, a smart wearable device, a personal computer, a laptop computer, a smart television, a smart appliance, a smart automobile, a networked computer, etc.
  • the local computing device 504 may be a dedicated device such as a hub or gateway that can establish a communication link with the communication module 552 and potentially the remote computing device 506 , where communication with the remote computing device 506 is necessary or desirable.
  • the local computing device 504 may further include a communication module 630 for wireless communication with the communication module 552 of the drug delivery device 502 , for example by using Bluetooth or Bluetooth Low Energy protocol. Alternatively, other wireless protocols may be used by the communication module 552 , such as radio-frequency identification (RFID), Zigbee, Wi-Fi, near field communication (NFC), and others.
  • the local computing device 504 may also include the display 632 (e.g., a touchscreen) to be used to display information (e.g., instructional prompts and/or informational prompts) to the user.
  • the local computing device 504 may include other output devices other than the display 632 to communicate with the user, such as a speaker 634 for example.
  • the speaker 634 may be controlled by the processor(s) 620 to provide an audible form of the instructions displayed in written form on the display 632 .
  • the local computing device 504 may also include one or more communication modules, which may be the same as or different from the communication module 630 , that may be used to communicate with one or more networks 640 , 642 .
  • the network 640 may be a wireless radio frequency network, such as a cellular mobile device network
  • the network 642 may be a network of computing devices, such as the Internet.
  • the networks 640 , 642 may be in communication with each other, such that the local computing device 504 may communicate with the remote computing device 506 over the network 640 , the network 642 or a combination of the networks 640 , 642 .
  • the remote computing device 624 may include a communication module 636 to receive communications from the networks 640 , 642 .
  • each of the local computing device 504 and the remote computing device 506 is separate from, and spaced apart from, the drug delivery device 502 , and therefore each may be considered to be an “external computing device” relative to the drug delivery device 502 .
  • FIG. 6 illustrated is a flow diagram of one embodiment of a method 700 of providing social support to a patient associated with the drug delivery device 502 .
  • the memory 622 of the local computing device 504 and/or the memory 626 of the remote computing device 506 may store one or more computer-executable instructions that, when executed by the processor 620 of the local computing device 504 and/or the processor of the 624 of the remote computing device 506 , cause the processor 620 of the local computing device 504 and/or the processor of the 624 of the remote computing device 506 to carry out the actions described below relative to the method 700 .
  • the method 700 may leverage social networking services (e.g., Facebook, Twitter, etc.) that provide access to groups of users who are already connected, or who can easily be connected, to the patient.
  • social networking services e.g., Facebook, Twitter, etc.
  • the patient may be more likely to comply with a treatment regimen (e.g., a therapeutic regimen) for treating a medical condition of the patient with drug delivery device 502 .
  • the method 700 may begin with associating the patient with a support group or multiple support groups (see block 710 ).
  • the support group may be a group of people and/or organizations having an interest in the patient complying with the treatment regimen.
  • the support group may include a healthcare provider (e.g., a doctor, nurse, etc.), a caregiver, a family member, a friend, a medical device manufacturer, an insurance company, and/or another individual using a similar drug delivery device and/or having a similar medical condition.
  • the support group may be a pre-existing online community of individuals connected through a social networking service, such as a Facebook group.
  • the support group may consist of the patient's Facebook friends.
  • the association of the patient with the support group may be accomplished in a variety of different manners.
  • the patient may select (via, for example, a mobile application executing on the local computing device 504 ) a pre-existing group (e.g., the patient's Facebook friends) to be the support group.
  • the patient's selection may be transmitted to the remote computing device 506 which subsequently associates the patient with the patient-selected support group.
  • the remote computing device 506 may register identity information about the patient (e.g., age, height, weight, medical condition, etc.) and then associate the patient with individuals sharing similar identity information.
  • the associating the patient with a support group may include initially collecting data (e.g., GPS data) from the local computing device 504 about the geographic location of the patient and/or the drug delivery device 502 . Based on this data, the remote computing device 506 may choose individuals who are physically near the geographic location of the patient as the support group.
  • the geographic-based method of associating the patient with a support group may be combined with any of the foregoing methods of association, such that the geographic location of the patient is only one factor in the selection of an appropriate support group.
  • the patient may be presented with map of nearby support groups from which the patient can selected a desired support group.
  • the method 700 may involve receiving, at the local computing device 504 and/or at the remote computing device 506 , data representative of a condition and/or an operational state of the drug delivery device 502 (see block 720 ).
  • the data may be in the form of one or more of the reports similar to those described above in connection with the method 200 and/or the method 300 .
  • the drug delivery device 502 may transmit sensor data, collected by the sensors onboard the drug delivery device 502 , to the local computing device 504 , which in turn, may analyze the sensor data to generate a report representative of a condition and/or an operational state of the drug delivery device 502 and then transmit that report to the remote computing device 506 .
  • the sensor data may be transmitted directly to the remote computing device 506 , which may then analyze the sensor data to determine the condition and/or operational state of the drug delivery device 502 .
  • the drug delivery device 502 may analyze the sensor data and generate the report representative the condition and/or an operational state of a drug delivery device 502 , and then transmit that report to the local computing device 504 and/or the remote computing device 506 .
  • the local computing device 504 and/or the remote computing device 506 may analyze the data to determine if the patient has complied with a treatment regimen (see block 730 ). This determination may involve a comparison of the data representative of the condition and/or the operational state of the drug delivery device 502 with a predefined criteria stored in the memory 622 of the local computing device 504 and/or the memory 626 of the remote computing device 506 .
  • the predefined criteria may specify, for example, the frequency with which the patient is to receive an injection of a medicament, the amount or dose of medicament to be received by the patient, the temperature of the medicament at the time of injection, the type of medicament to be received by the patient, and/or the sequence in which a medicament is to be injected along with other medicaments.
  • the predefined criteria may indicate that the patient is to receive an injection of the medicament every day before noon.
  • compliance with the treatment regimen may be involve a determination that the operational state of the drug delivery device 502 corresponds to the drug delivery device 502 having completed delivery of the medicament to the patient. Judging whether delivery of the medicament to the patient has been successful may accomplished in a manner consistent with the method 200 and/or the method 300 .
  • successful drug delivery may be determined if both the needle shield 522 has been moved in the distal direction relative to the delivery cannula 514 and the plunger 531 has completed its delivery stroke by moving from its proximal position to its distal position.
  • Other conditions or states that may be considered to confirm successful delivery of the medicament to the patient include an indication that the actuator 540 has been triggered (e.g., depressed) and/or the amount of medicament remaining in the reservoir 512 .
  • the method 700 may return to block 720 , where the local computing device 504 and/or the remote computing device 506 waits for the reception of new data representative of at least one of a condition or an operational state of a drug delivery device 502 .
  • the local computing device 504 and/or the remote computing device 506 may transmit a communication to the support group associated with the patient requesting the support group to send a message of praise or congratulation to the patient.
  • the local computing device 504 and/or the remote computing device 506 may transmit a communication to the support group associated with the patient in order to initiate an intervention with the patient (see block 740 ).
  • the communication may be sent through a social networking service or some other mechanism (e.g., email, SMS message, push notification, telephone, etc.).
  • the communication may request the support group to counsel the patient about the treatment regimen. In some embodiments, the request may suggest that the support group send a message to the patient encouraging the patient to comply with the treatment regimen.
  • the request may include pre-written message and/or an ideogram (e.g., an emoji) which can be sent, on demand, by a member of the support group to the patient.
  • the request may ask the support group to actively intervene by, for example, meeting with the patient in-person, physically assisting the patient with their use of the drug delivery device, and/or actually administering the medicament to the patient with the drug delivery device. Active intervention may be especially beneficial for patients suffering from dementia and other forms of cognitive decline.
  • the message asking the support group to intervene may include an indication of the patient's limited cognitive abilities so that the support group appreciates the patient's vulnerability to forget their medication schedule.
  • the method 700 may include the local computing device 504 and/or the remote computing device 506 receiving a communication from the support group providing the requested counseling (see block 750 ).
  • the communication may in the form of a message sent through a social networking service or some other mechanism (e.g., email, SMS message, push notification, telephone, etc.).
  • the message may include words of encouragement, coaching, advice, a reminder, or any other communication likely to urge the patient to comply with the treatment regimen.
  • the method 700 may forward the communication to the patient (block 760 ). This may involve displaying the communication on the display 632 of the local computing device 504 and/or generating a sound with the speaker 634 of the local computing device 504 .
  • the support provided to the patient by the method 700 is reactive support since it is provided in response to the patient's failure to comply with the treatment regimen.
  • the methods and systems disclosed herein may be configured to provide the patient with proactive support. This type of support reduces the likelihood that the patient will fail to comply with the treatment regimen by taking preventative measures before a violation of the treatment regimen occurs.
  • the local computing device 504 and/or the remote computing device 506 may evaluate the treatment region to determine if the patient is scheduled to receive a dose of the medicament in the near future (e.g., tomorrow, tonight, in the next hour, etc.).
  • the local computing device 504 and/or the remote computing device 506 may transmit a communication to the support group associated with the patient.
  • This communication may include a request for support group to remind the patient to take their upcoming dose of the medicament. Similar to the method 700 , these steps may be performed by executing non-transitory, computer-executable instructions included in a mobile software application, or other module, stored in the memory 622 of the local computing device 504 and/or the memory 626 of the remote computing device 506 .
  • members of the support group may send one or more messages through a social networking service or some other mechanism (e.g., email, SMS message, push notification, telephone, etc.) to the patient reminding him or her to take their medication.
  • a social networking service e.g., email, SMS message, push notification, telephone, etc.
  • the patient may be less likely to miss a scheduled dose of the medicament.
  • the local computing device 504 and/or the remote computing device 506 may be configured to receive a request from the patient for help and/or support, and in response to that request, automatically contact an appropriate individual or organization.
  • a mobile software application executing on the local computing device 504 may display a help button or icon that, when selected by the patient, causes the local computing device 504 to transmit a help request to a healthcare provider (e.g., doctor, nurse practitioner, nurse, etc.), caregiver, medical device manufacturer, support group, or any other individual or organization capable helping the patient.
  • a healthcare provider e.g., doctor, nurse practitioner, nurse, etc.
  • the help request may solicit technical support for proper use of the drug delivery device, emotional support, information about the medicament and its side effects, and/or any other type of support.
  • selecting the help button may cause the smartphone to automatically call a support hotline, call a member of a support group, and/or open a website (e.g., a website including a list a frequently asked questions) in a web browser executing on the smartphone. Accordingly, the patient may be able to obtain immediate support for his or her questions or concerns.
  • the methods and systems disclosed herein have several technical effects on the process of monitoring the use of a drug delivery device and ensuring patient compliance with a treatment regimen.
  • One technical effect is the computer-implemented determination of the condition and/or operational state of the drug delivery device and the automatic distribution of this information to a social network for further processing and/or notification of a support group. Accordingly, a caregiver is not required to manually determine, or manually notify a support group of, the condition and/or operational state of the drug delivery device to ensure patient compliance.
  • Another technical effect is that the presently disclosed systems and methods streamline the process of identifying an appropriate support group for the patient.
  • the systems and methods may automatically associate the patient with a support group located geographically nearby the patient and/or a support group including members with whom the patient has a personal and/or professional relationship. Automating the process of associating the patient with a support group reduces the search burden on the patient or caregiver.
  • the patient may be associated with a support group based upon the patient's pre-existing social networking based relationships (e.g., Facebook friendships), which may further simplify the process of identifying appropriate members for the support group.
  • Yet another technical effect of the presently disclosed methods and systems is that they automatically send a help request to the support group in response to a determination of the patient's non-compliance with the treatment regimen.
  • the systems and methods provide a relatively simplistic trigger for notifying the support group, which can help minimize the amount of data processing needed to alert the support group. While the foregoing mentions several technical effects associated with the invention, other technical effects will be readily apparent to one of ordinary skill in the art upon a review of this disclosure.
  • the above description describes various systems and methods for use with a drug delivery device. It should be clear that the system, drug delivery device or methods can further comprise use of a medicament listed below with the caveat that the following list should neither be considered to be all inclusive nor limiting.
  • the medicament will be contained in a reservoir.
  • the reservoir is a primary container that is either filled or pre-filled for treatment with the medicament.
  • the primary container can be a cartridge or a pre-filled syringe.
  • the drug delivery device or more specifically the reservoir of the device may be filled with colony stimulating factors, such as granulocyte colony-stimulating factor (G-CSF).
  • G-CSF agents include, but are not limited to, Neupogen® (filgrastim) and Neulasta® (pegfilgrastim).
  • the drug delivery device may be used with various pharmaceutical products, such as an erythropoiesis stimulating agent (ESA), which may be in a liquid or a lyophilized form.
  • ESA erythropoiesis stimulating agent
  • An ESA is any molecule that stimulates erythropoiesis, such as Epogen® (epoetin alfa), Aranesp® (darbepoetin alfa), Dynepo® (epoetin delta), Mircera® (methyoxy polyethylene glycol-epoetin beta), Hematide®, MRK-2578, INS-22, Retacrit® (epoetin zeta), Neorecormon® (epoetin beta), Silapo® (epoetin zeta), Binocrit® (epoetin alfa), epoetin alfa Hexal, Abseamed® (epoetin alfa), Ratioepo® (epoetin theta), Eporatio® (epoetin theta), Biopoin® (epoetin theta), epoetin alfa
  • An ESA can be an erythropoiesis stimulating protein.
  • erythropoiesis stimulating protein means any protein that directly or indirectly causes activation of the erythropoietin receptor, for example, by binding to and causing dimerization of the receptor.
  • Erythropoiesis stimulating proteins include erythropoietin and variants, analogs, or derivatives thereof that bind to and activate erythropoietin receptor; antibodies that bind to erythropoietin receptor and activate the receptor; or peptides that bind to and activate erythropoietin receptor.
  • Erythropoiesis stimulating proteins include, but are not limited to, epoetin alfa, epoetin beta, epoetin delta, epoetin omega, epoetin iota, epoetin zeta, and analogs thereof, pegylated erythropoietin, carbamylated erythropoietin, mimetic peptides (including EMP1/hematide), and mimetic antibodies.
  • Exemplary erythropoiesis stimulating proteins include erythropoietin, darbepoetin, erythropoietin agonist variants, and peptides or antibodies that bind and activate erythropoietin receptor (and include compounds reported in U.S. Publication Nos. 2003/0215444 and 2006/0040858, the disclosures of each of which is incorporated herein by reference in its entirety) as well as erythropoietin molecules or variants or analogs thereof as disclosed in the following patents or patent applications, which are each herein incorporated by reference in its entirety: U.S. Pat. Nos.
  • Examples of other pharmaceutical products for use with the device may include, but are not limited to, antibodies such as Vectibix® (panitumumab), XgevaTM (denosumab) and ProliaTM (denosamab); other biological agents such as Enbrel® (etanercept, TNF-receptor/Fc fusion protein, TNF blocker), Neulasta® (pegfilgrastim, pegylated filgastrim, pegylated G-CSF, pegylated hu-Met-G-CSF), Neupogen® (filgrastim , G-CSF, hu-MetG-CSF), and Nplate® (romiplostim); small molecule drugs such as Sensipar® (cinacalcet).
  • antibodies such as Vectibix® (panitumumab), XgevaTM (denosumab) and ProliaTM (denosamab); other biological agents such as Enbrel® (et
  • the device may also be used with a therapeutic antibody, a polypeptide, a protein or other chemical, such as an iron, for example, ferumoxytol, iron dextrans, ferric glyconate, and iron sucrose.
  • a therapeutic antibody for example, ferumoxytol, iron dextrans, ferric glyconate, and iron sucrose.
  • the pharmaceutical product may be in liquid form, or reconstituted from lyophilized form.
  • proteins are the specific proteins set forth below, including fusions, fragments, analogs, variants or derivatives thereof:
  • OPGL specific antibodies, peptibodies, and related proteins, and the like also referred to as RANKL specific antibodies, peptibodies and the like
  • fully humanized and human OPGL specific antibodies particularly fully humanized monoclonal antibodies, including but not limited to the antibodies described in PCT Publication No. WO 03/002713, which is incorporated herein in its entirety as to OPGL specific antibodies and antibody related proteins, particularly those having the sequences set forth therein, particularly, but not limited to, those denoted therein: 9H7; 18B2; 2D8; 2E11; 16E1; and 22B3, including the OPGL specific antibodies having either the light chain of SEQ ID NO:2 as set forth therein in FIG. 2 and/or the heavy chain of SEQ ID NO:4, as set forth therein in FIG. 4 , each of which is individually and specifically incorporated by reference herein in its entirety fully as disclosed in the foregoing publication;
  • IL-4 receptor specific antibodies particularly those that inhibit activities mediated by binding of IL-4 and/or IL-13 to the receptor, including those described in PCT Publication No. WO 2005/047331 or PCT Application No. PCT/US2004/37242 and in U.S. Publication No.
  • Interleukin 1-receptor 1 (“IL1-R1”) specific antibodies, peptibodies, and related proteins, and the like, including but not limited to those described in U.S. Publication No. 2004/097712, which is incorporated herein by reference in its entirety in parts pertinent to IL1-R1 specific binding proteins, monoclonal antibodies in particular, especially, without limitation, those designated therein: 15CA, 26F5, 27F2, 24E12, and 10H7, each of which is individually and specifically incorporated by reference herein in its entirety fully as disclosed in the aforementioned publication;
  • Ang2 specific antibodies, peptibodies, and related proteins, and the like including but not limited to those described in PCT Publication No. WO 03/057134 and U.S. Publication No. 2003/0229023, each of which is incorporated herein by reference in its entirety particularly in parts pertinent to Ang2 specific antibodies and peptibodies and the like, especially those of sequences described therein and including but not limited to: L1(N); L1(N) WT; L1(N) 1K WT; 2xL1(N); 2xL1(N) WT; Con4 (N), Con4 (N) 1K WT, 2xCon4 (N) 1K; L1C; L1C 1K; 2xL1C; Con4C; Con4C 1K; 2xCon4C 1K; Con4-L1 (N); Con4-L1C; TN-12-9 (N); C17 (N); TN8-8(N); TN8-14 (N); Con 1 (N), also including anti-
  • WO 2003/030833 which is incorporated herein by reference in its entirety as to the same, particularly Ab526; Ab528; Ab531; Ab533; Ab535; Ab536; Ab537; Ab540; Ab543; Ab544; Ab545; Ab546; A551; Ab553; Ab555; Ab558; Ab559; Ab565; AbF1AbFD; AbFE; AbFJ; AbFK; AbG1D4; AbGC1E8; AbH1C12; AblA1; AblF; AblK, AblP; and AblP, in their various permutations as described therein, each of which is individually and specifically incorporated by reference herein in its entirety fully as disclosed in the foregoing publication;
  • NGF specific antibodies, peptibodies, and related proteins, and the like including, in particular, but not limited to those described in U.S. Publication No. 2005/0074821 and U.S. Pat. No. 6,919,426, which are incorporated herein by reference in their entirety particularly as to NGF-specific antibodies and related proteins in this regard, including in particular, but not limited to, the NGF-specific antibodies therein designated 4D4, 4G6, 6H9, 7H2, 14D10 and 14D11, each of which is individually and specifically incorporated by reference herein in its entirety fully as disclosed in the foregoing publication;
  • IGF-1 receptor specific antibodies such as those described in PCT Publication No. WO 06/069202, which is incorporated herein by reference in its entirety as to IGF-1 receptor specific antibodies and related proteins, including but not limited to the IGF-1 specific antibodies therein designated L1H1, L2H2, L3H3, L4H4, L5H5, L6H6, L7H7, L8H8, L9H9, L10H10, L11H11, L12H12, L13H13, L14H14, L15H15, L16H16, L17H17, L18H18, L19H19, L20H20, L21H21, L22H22, L23H23, L24H24, L25H25, L26H26, L27H27, L28H28, L29H29, L30H30, L31H31, L32H32, L33H33, L34H34, L35H35, L36H36, L37H37,
  • anti-IGF-1R antibodies for use in the methods and compositions of the present invention are each and all of those described in:
  • B7RP-1 B-7 related protein 1 specific antibodies, peptibodies, related proteins and the like
  • B7RP-1 also is referred to in the literature as B7H2, ICOSL, B7h, and CD275
  • B7RP-specific fully human monoclonal IgG2 antibodies particularly fully human IgG2 monoclonal antibody that binds an epitope in the first immunoglobulin-like domain of B7RP-1, especially those that inhibit the interaction of B7RP-1 with its natural receptor, ICOS, on activated T cells in particular, especially, in all of the foregoing regards, those disclosed in U.S. Publication No. 2008/0166352 and PCT Publication No.
  • WO 07/011941 which are incorporated herein by reference in their entireties as to such antibodies and related proteins, including but not limited to antibodies designated therein as follow: 16H (having light chain variable and heavy chain variable sequences SEQ ID NO:1 and SEQ ID NO:7 respectively therein); 5D (having light chain variable and heavy chain variable sequences SEQ ID NO:2 and SEQ ID NO:9 respectively therein); 2H (having light chain variable and heavy chain variable sequences SEQ ID NO:3 and SEQ ID NO:10 respectively therein); 43H (having light chain variable and heavy chain variable sequences SEQ ID NO:6 and SEQ ID NO:14 respectively therein); 41H (having light chain variable and heavy chain variable sequences SEQ ID NO:5 and SEQ ID NO:13 respectively therein); and 15H (having light chain variable and heavy chain variable sequences SEQ ID NO:4 and SEQ ID NO:12 respectively therein), each of which is individually and specifically incorporated by reference herein in its entirety fully as disclosed in the foregoing publication;
  • IL-15 specific antibodies, peptibodies, and related proteins, and the like such as, in particular, humanized monoclonal antibodies, particularly antibodies such as those disclosed in U.S. Publication Nos. 2003/0138421; 2003/023586; and 2004/0071702; and U.S. Pat. No. 7,153,507, each of which is incorporated herein by reference in its entirety as to IL-15 specific antibodies and related proteins, including peptibodies, including particularly, for instance, but not limited to, HuMax IL-15 antibodies and related proteins, such as, for instance, 146B7;
  • IFN gamma specific antibodies peptibodies, and related proteins and the like, especially human IFN gamma specific antibodies, particularly fully human anti-IFN gamma antibodies, such as, for instance, those described in U.S. Publication No. 2005/0004353, which is incorporated herein by reference in its entirety as to IFN gamma specific antibodies, particularly, for example, the antibodies therein designated 1118; 1118*; 1119; 1121; and 1121*.
  • the entire sequences of the heavy and light chains of each of these antibodies, as well as the sequences of their heavy and light chain variable regions and complementarity determining regions, are each individually and specifically incorporated by reference herein in its entirety fully as disclosed in the foregoing publication and in Thakur et al.
  • Specific antibodies include those having the heavy chain of SEQ ID NO:17 and the light chain of SEQ ID NO:18; those having the heavy chain variable region of SEQ ID NO:6 and the light chain variable region of SEQ ID NO:8; those having the heavy chain of SEQ ID NO:19 and the light chain of SEQ ID NO:20; those having the heavy chain variable region of SEQ ID NO:10 and the light chain variable region of SEQ ID NO:12; those having the heavy chain of SEQ ID NO:32 and the light chain of SEQ ID NO:20; those having the heavy chain variable region of SEQ ID NO:30 and the light chain variable region of SEQ ID NO:12; those having the heavy chain sequence of SEQ ID NO:21 and the light chain sequence of SEQ ID NO:22; those having the heavy chain variable region of SEQ ID NO:14 and the light chain variable region of SEQ ID NO:
  • TALL-1 specific antibodies such as those described in U.S. Publication Nos. 2003/0195156 and 2006/0135431, each of which is incorporated herein by reference in its entirety as to TALL-1 binding proteins, particularly the molecules of Tables 4 and 5B, each of which is individually and specifically incorporated by reference herein in its entirety fully as disclosed in the foregoing publications;
  • PTH Parathyroid hormone
  • TPO-R Thrombopoietin receptor
  • TRAIL-R2 specific antibodies, peptibodies, related proteins and the like such as those described in U.S. Pat. No. 7,521,048, which is herein incorporated by reference in its entirety, particularly in parts pertinent to proteins that bind TRAIL-R2;
  • Activin A specific antibodies, peptibodies, related proteins, and the like, including but not limited to those described in U.S. Publication No. 2009/0234106, which is herein incorporated by reference in its entirety, particularly in parts pertinent to proteins that bind Activin A;
  • TGF-beta specific antibodies, peptibodies, related proteins, and the like including but not limited to those described in U.S. Pat. No. 6,803,453 and U.S. Publication No. 2007/0110747, each of which is herein incorporated by reference in its entirety, particularly in parts pertinent to proteins that bind TGF-beta;
  • Amyloid-beta protein specific antibodies including but not limited to those described in PCT Publication No. WO 2006/081171, which is herein incorporated by reference in its entirety, particularly in parts pertinent to proteins that bind amyloid-beta proteins.
  • One antibody contemplated is an antibody having a heavy chain variable region comprising SEQ ID NO:8 and a light chain variable region having SEQ ID NO:6 as disclosed in the foregoing publication;
  • c-Kit specific antibodies including but not limited to those described in U.S. Publication No. 2007/0253951, which is incorporated herein by reference in its entirety, particularly in parts pertinent to proteins that bind c-Kit and/or other stem cell factor receptors;
  • OX40L specific antibodies, peptibodies, related proteins, and the like including but not limited to those described in U.S. Publication No. 2006/0002929, which is incorporated herein by reference in its entirety, particularly in parts pertinent to proteins that bind OX40L and/or other ligands of the OX40 receptor; and
  • Activase® (alteplase, tPA); Aranesp® (darbepoetin alfa); Epogen® (epoetin alfa, or erythropoietin); GLP-1, Avonex® (interferon beta-1a); Bexxar® (tositumomab, anti-CD22 monoclonal antibody); Betaseron® (interferon-beta); Campath® (alemtuzumab, anti-CD52 monoclonal antibody); Dynepo® (epoetin delta); Velcade® (bortezomib); MLN0002 (anti- ⁇ 4 ⁇ 7 mAb); MLN1202 (anti-CCR2 chemokine receptor mAb); Enbrel® (etanercept, TNF-receptor/Fc fusion protein, TNF blocker); Eprex® (epoetin alfa); Erbitux® (cet
  • Tysabri® (natalizumab, anti- ⁇ 4integrin mAb); Valortim® (MDX-1303, anti-B. anthracis protective antigen mAb); ABthraxTM; Vectibix® (panitumumab); Xolair® (omalizumab); ETI211 (anti-MRSA mAb); IL-1 trap (the Fc portion of human IgG1 and the extracellular domains of both IL-1 receptor components (the Type I receptor and receptor accessory protein)); VEGF trap (Ig domains of VEGFR1 fused to IgG1 Fc); Zenapax® (daclizumab); Zenapax® (daclizumab, anti-IL-2R ⁇ mAb); Zevalin® (ibritumomab tiuxetan); Zetia® (ezetimibe); Orencia® (atacicept, TACI-Ig); anti-CD80 monoclonal
  • sclerostin antibody such as but not limited to romosozumab, blosozumab, or BPS 804 (Novartis).
  • therapeutics such as rilotumumab, bixalomer, trebananib, ganitumab, conatumumab, motesanib diphosphate, brodalumab, vidupiprant, panitumumab, denosumab, NPLATE, PROLIA, VECTIBIX or XGEVA.
  • a monoclonal antibody that binds human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9), e.g. U.S. Pat. No. 8,030,547, U.S. Publication No.
  • talimogene laherparepvec or another oncolytic HSV for the treatment of melanoma or other cancers.
  • oncolytic HSV include, but are not limited to talimogene laherparepvec (U.S. Pat. Nos. 7,223,593 and 7,537,924); OncoVEXGALV/CD (U.S. Pat. No. 7,981,669); OrienX010 (Lei et al. (2013), World J. Gastroenterol., 19:5138-5143); G207, 1716; NV1020; NV12023; NV1034 and NV1042 (Vargehes et al. (2002), Cancer Gene Ther., 9(12):967-978).
  • TIMPs are endogenous tissue inhibitors of metalloproteinases (TIMPs) and are important in many natural processes.
  • TIMP-3 is expressed by various cells or and is present in the extracellular matrix; it inhibits all the major cartilage-degrading metalloproteases, and may play a role in role in many degradative diseases of connective tissue, including rheumatoid arthritis and osteoarthritis, as well as in cancer and cardiovascular conditions.
  • the amino acid sequence of TIMP-3, and the nucleic acid sequence of a DNA that encodes TIMP-3 are disclosed in U.S. Pat. No. 6,562,596, issued May 13, 2003, the disclosure of which is incorporated by reference herein. Description of TIMP mutations can be found in U.S. Publication No. 2014/0274874 and PCT Publication No. WO 2014/152012.
  • CGRP human calcitonin gene-related peptide
  • bispecific T cell engager antibody e.g. Blinotumomab
  • Blinotumomab can be used in the device.
  • included can be an APJ large molecule agonist e.g., apelin or analogues thereof in the device. Information relating to such molecules can be found in PCT Publication No. WO 2014/099984.
  • the medicament comprises a therapeutically effective amount of an anti-thymic stromal lymphopoietin (TSLP) or TSLP receptor antibody.
  • TSLP anti-thymic stromal lymphopoietin
  • anti-TSLP antibodies that may be used in such embodiments include, but are not limited to, those described in U.S. Pat. Nos. 7,982,016, and 8,232,372, and U.S. Publication No. 2009/0186022.
  • anti-TSLP receptor antibodies include, but are not limited to, those described in U.S. Pat. No. 8,101,182.
  • the medicament comprises a therapeutically effective amount of the anti-TSLP antibody designated as AS within U.S. Pat. No. 7,982,016.

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US15/931,364 Active US11738146B2 (en) 2014-06-03 2020-05-13 Drug delivery system and method of use
US17/534,173 Active 2036-05-27 US11992659B2 (en) 2014-06-03 2021-11-23 Controllable drug delivery system and method of use
US17/940,422 Abandoned US20230098606A1 (en) 2014-06-03 2022-09-08 Devices and methods for assisting a user of a drug delivery device
US18/111,064 Active 2036-05-30 US12569622B2 (en) 2014-06-03 2023-02-17 Systems and methods for remotely processing data collected by a drug delivery device
US18/218,782 Pending US20230355877A1 (en) 2014-06-03 2023-07-06 Drug delivery system and method of use
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US15/315,922 Abandoned US20170124285A1 (en) 2014-06-03 2015-06-03 Devices and methods for assisting a user of a drug delivery device
US15/315,896 Abandoned US20170098058A1 (en) 2014-06-03 2015-06-03 Systems and methods for remotely processing data collected by a drug delivery device
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Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180308571A1 (en) * 2015-10-09 2018-10-25 Duke University Medication administration and adherence systems and related methods
US10182969B2 (en) 2015-03-10 2019-01-22 Regeneron Pharmaceuticals, Inc. Aseptic piercing system and method
WO2019018169A1 (en) 2017-07-21 2019-01-24 Amgen Inc. PERMEABLE GAS SEALING ELEMENT FOR MEDICINE CONTAINER AND METHODS OF ASSEMBLY
WO2019022951A1 (en) 2017-07-25 2019-01-31 Amgen Inc. DRUG DELIVERY DEVICE WITH GEAR MODULE AND ASSEMBLY METHOD THEREOF
WO2019022950A1 (en) 2017-07-25 2019-01-31 Amgen Inc. DRUG DELIVERY DEVICE WITH CONTAINER ACCESS SYSTEM AND ASSEMBLY METHOD THEREOF
WO2019036181A1 (en) 2017-08-18 2019-02-21 Amgen Inc. BODY INJECTOR WITH STERILE ADHESIVE PATCH
WO2019070552A1 (en) 2017-10-06 2019-04-11 Amgen Inc. DRUG DELIVERY DEVICE COMPRISING A LOCKOUT ASSEMBLY AND ASSOCIATED ASSEMBLY METHOD
WO2019074579A1 (en) 2017-10-09 2019-04-18 Amgen Inc. DRUG DELIVERY DEVICE COMPRISING A DRIVE ASSEMBLY AND ASSEMBLY METHOD THEREOF
WO2019090079A1 (en) 2017-11-03 2019-05-09 Amgen Inc. System and approaches for sterilizing a drug delivery device
WO2019090303A1 (en) 2017-11-06 2019-05-09 Amgen Inc. Fill-finish assemblies and related methods
US10646652B2 (en) 2014-06-03 2020-05-12 Amgen Inc. Controllable drug delivery system and method of use
US20210398664A1 (en) * 2016-03-14 2021-12-23 Fenwal, Inc. Cell processing method
US11547801B2 (en) 2017-05-05 2023-01-10 Regeneron Pharmaceuticals, Inc. Auto-injector
USD1007676S1 (en) 2021-11-16 2023-12-12 Regeneron Pharmaceuticals, Inc. Wearable autoinjector

Families Citing this family (214)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12014328B2 (en) * 2005-07-13 2024-06-18 Vccb Holdings, Inc. Medicine bottle cap with electronic embedded curved display
ATE480278T1 (de) 2005-09-12 2010-09-15 Unomedical As Einfürungssystem für ein infusionsset mit einem ersten und zweiten federeinheit
CA2792138A1 (en) 2010-03-30 2011-10-06 Unomedical A/S Medical device
US10194938B2 (en) 2011-03-14 2019-02-05 UnoMedical, AS Inserter system with transport protection
EP2763723B1 (en) 2011-10-05 2016-04-13 Unomedical A/S Inserter for simultaneous insertion of multiple transcutaneous parts
EP2583715A1 (en) 2011-10-19 2013-04-24 Unomedical A/S Infusion tube system and method for manufacture
US10441717B2 (en) 2014-04-15 2019-10-15 Insulet Corporation Monitoring a physiological parameter associated with tissue of a host to confirm delivery of medication
DK3161693T3 (da) * 2014-06-27 2021-07-12 Sanofi Aventis Deutschland System og fremgangsmåde til overvågning
US11478583B2 (en) 2014-10-03 2022-10-25 Enable Injections, Inc. Medical fluid transfer and injection apparatus and method
DK3265152T3 (da) 2015-03-06 2020-03-23 Attila Berey Dataregistreringsorgan, særligt til en pen-lignende lægemiddelindgivesesindretning
EP3103491A1 (en) * 2015-06-10 2016-12-14 Sanofi-Aventis Deutschland GmbH A device for attachment to a drug delivery device
JP7082568B2 (ja) 2015-12-09 2022-06-08 アムジエン・インコーポレーテツド 信号伝達キャップ付き自動注射器
WO2017106247A1 (en) * 2015-12-14 2017-06-22 Amgen Inc. Drug delivery storage device and system
EP3184135A1 (en) 2015-12-22 2017-06-28 Carebay Europe Ltd. Communication device for transmitting information from a medicament delivery device
PL3397321T3 (pl) 2015-12-30 2023-01-23 Ascendis Pharma A/S Automatyczny wstrzykiwacz z regulacją temperatury
JP7335072B2 (ja) 2015-12-30 2023-08-29 アセンディス ファーマ エー／エス 使用済みカートリッジの検出を備える自動注射器および関連の方法
HUE071013T2 (hu) 2015-12-30 2025-07-28 Ascendis Pharma As Autoinjektor adaptálódó légkiürítõ szerkezettel
WO2017114912A1 (en) 2015-12-30 2017-07-06 Ascendis Pharma A/S Auto injector with charger safety
ES2924040T3 (es) 2015-12-30 2022-10-04 Ascendis Pharma As Autoinyector con sistema de retención de cartucho
US11154661B2 (en) 2016-01-06 2021-10-26 Amgen Inc. Auto-injector with signaling electronics
WO2017125817A1 (en) 2016-01-19 2017-07-27 Unomedical A/S Cannula and infusion devices
US20170237486A1 (en) * 2016-02-11 2017-08-17 West Pharmaceutical Services, Inc. Visual communication between mobile communication devices and drug delivery devices
JOP20170042B1 (ar) * 2016-02-12 2022-09-15 Amgen Inc وسيلة توصيل عقار، طريقة تصنيعه وطريقة استخدامه
KR101957963B1 (ko) * 2016-03-11 2019-07-04 이오플로우 주식회사 약액 주입 장치
US10747850B2 (en) * 2016-03-29 2020-08-18 International Business Machines Corporation Medication scheduling and alerts
JP7074684B2 (ja) 2016-04-08 2022-05-24 アムジエン・インコーポレーテツド 薬物送達デバイス、製造方法、及び使用方法
US10518039B2 (en) * 2016-04-29 2019-12-31 Verily Life Sciences Llc Apparatus and methods for tracking administering of medication by medication injection devices
US10953155B2 (en) 2016-04-29 2021-03-23 Verily Life Sciences Llc Pressure sensor in plunger head to wake up electronics
WO2017200989A1 (en) 2016-05-16 2017-11-23 Amgen Inc. Data encryption in medical devices with limited computational capability
US10751476B2 (en) * 2016-06-09 2020-08-25 Becton, Dickinson And Company Actuator assembly for drug delivery system
JP7055787B2 (ja) * 2016-07-14 2022-04-18 サノフイ 薬剤送達デバイス
US11730892B2 (en) 2016-08-01 2023-08-22 West Pharma. Services IL, Ltd. Partial door closure prevention spring
AU2017311546B2 (en) * 2016-08-09 2022-09-15 F. Hoffmann-La Roche Ag Ambulatory infusion device
JP6826392B2 (ja) * 2016-08-10 2021-02-03 持田製薬株式会社 自動注射器
JP6415498B2 (ja) * 2016-08-24 2018-10-31 株式会社スズケン 医薬品在庫管理システム及び、医薬品在庫管理方法
EP3525847A1 (en) * 2016-10-13 2019-08-21 SHL Medical AG A controller for a medicament delivery device
WO2018069150A1 (en) * 2016-10-13 2018-04-19 Carebay Europe Ltd. A controller for a medicament delivery device
EP3526913B1 (en) * 2016-10-14 2025-12-10 SHL Medical AG A self-administrative medicament device configured to send data through the human body
ES2985905T3 (es) 2016-11-22 2024-11-07 Lts Device Tech Ltd Aparato para suministrar una sustancia terapéutica
EP3326671A1 (en) 2016-11-29 2018-05-30 Carebay Europe Ltd. Activation assembly for a medicament delivery device
WO2018106475A1 (en) 2016-12-05 2018-06-14 Quio Technologies Llc Communication and tracking system for disposable drug delivery devices
US20180165422A1 (en) * 2016-12-08 2018-06-14 Verily Life Sciences Llc Systems and methods for controlling the operational state of a medical device
AU2017387077B2 (en) * 2016-12-28 2023-07-27 Genentech, Inc. Injection monitoring device
US20180193563A1 (en) * 2017-01-09 2018-07-12 Verily Life Sciences Llc Systems and methods for wearable emergency drug injection devices
CN106964014B (zh) * 2017-02-13 2020-03-10 深圳麦科田生物医疗技术有限公司 一种输液管理方法及系统
LT3589340T (lt) 2017-02-28 2026-01-12 Eli Lilly And Company Vaistų leidimo įrenginio dozės aptikimas ir vaistų identifikavimas
ES2884153T3 (es) 2017-03-31 2021-12-10 Becton Dickinson Co Dispositivo inteligente de inyección y/o infusión portable
SG11201909160WA (en) * 2017-04-11 2019-10-30 Inhibrx Inc Multispecific polypeptide constructs having constrained cd3 binding and methods of using the same
CA3059927A1 (en) * 2017-04-19 2018-10-25 Medimmune, Llc E-connected auto-injectors
US9993209B1 (en) * 2017-04-24 2018-06-12 International Business Machines Corporation Dynamically monitoring environmental and physiological characteristics to generate a medicine ingestion alarm
US10489287B2 (en) 2017-05-15 2019-11-26 Bank Of America Corporation Conducting automated software testing using centralized controller and distributed test host servers
US10845955B2 (en) 2017-05-15 2020-11-24 Apple Inc. Displaying a scrollable list of affordances associated with physical activities
US10223248B2 (en) 2017-05-15 2019-03-05 Bank Of America Corporation Conducting automated software testing using centralized controller and distributed test host servers
CN115591054A (zh) 2017-05-23 2023-01-13 阿森迪斯药物股份有限公司（Dk） 自动注射器、系统和用于控制自动注射器的方法
WO2018218167A1 (en) 2017-05-25 2018-11-29 West Pharmaceutical Services, Inc. Smart syringe using nfc communication and capacitance detection
ES2976557T3 (es) * 2017-05-25 2024-08-05 Enable Injections Inc Aparato y método de inyección y transferencia de fluidos médicos con monitorización de cumplimiento
CN110691624B (zh) * 2017-05-30 2020-10-27 西部制药服务有限公司(以色列) Pcb的垂直组装
EP3630226B1 (en) 2017-05-30 2025-10-22 West Pharma. Services Il, Ltd. Modular drive train for wearable injector
WO2018231868A1 (en) 2017-06-13 2018-12-20 Irenix Medical, Inc. Active agent delivery devices and methods for using the same
WO2018237225A1 (en) * 2017-06-23 2018-12-27 Amgen Inc. Electronic drug delivery device comprising a cap activated by a switch assembly
MY203391A (en) 2017-06-29 2024-06-26 Ascendis Pharma As Auto injector with reconstitution handling support
KR102658959B1 (ko) 2017-06-30 2024-04-22 리제너론 파아마슈티컬스, 인크. 안티 롤 피쳐를 갖는 자동 주입기
US11717615B2 (en) 2017-07-14 2023-08-08 Mannkind Corporation Communication accessory for a drug delivery device
JP7252191B2 (ja) 2017-07-14 2023-04-04 サノフイ 包装アセンブリ
US20190053981A1 (en) * 2017-08-17 2019-02-21 Qualcomm Incorporated Temperature thresholding in drug dispensing devices
CN111050822B (zh) * 2017-08-31 2023-04-18 贝克顿·迪金森公司 检测注射期间施加的力的系统和方法
CN111278359A (zh) * 2017-10-26 2020-06-12 威里利生命科学有限责任公司 用于可体戴电子设备的两阶段部署启动唤醒机制
CN111263650B (zh) 2017-10-31 2022-06-21 诺和诺德股份有限公司 使用无线通信控制医疗装置
EP3706830B1 (en) * 2017-11-06 2024-08-07 Amgen Inc. Drug delivery device with placement and flow sensing
MA50557A (fr) * 2017-11-10 2020-09-16 Amgen Inc Pistons pour dispositifs d'administration de médicament
SG11202003865WA (en) * 2017-11-14 2020-05-28 Becton Dickinson Co Electronic modules for a syringe
WO2019096726A2 (en) 2017-11-14 2019-05-23 Sanofi Conserving power in an injection device
CA3082658A1 (en) 2017-11-15 2019-05-23 Desvac Drug delivery apparatus
JP7370969B2 (ja) * 2017-11-16 2023-10-30 アムジエン・インコーポレーテツド 薬物送達デバイスの扉ラッチ機構
CN107998488A (zh) * 2017-11-28 2018-05-08 广东嘉博制药有限公司 一种丁酸氯维地平脂肪乳注射液的输注系统
JP7203847B2 (ja) * 2017-12-19 2023-01-13 バイオコープ プロダクション ソシエテ アノニム 自動注射薬物送出装置
US11961600B2 (en) 2017-12-21 2024-04-16 Sanofi Supplementary device for attachment to an injection device
DK3727521T3 (da) 2017-12-21 2024-09-23 Sanofi Sa Bestemmelse af en status af en injektion
CN108154909A (zh) * 2017-12-22 2018-06-12 广东康之家云健康医药股份有限公司 一种顾客药耗跟踪系统
US20200390596A1 (en) 2018-01-03 2020-12-17 Irenix Medical, Inc. Therapeutic Agent Delivery Devices Having Integrated Pain Mitigation, and Methods for Using the Same
DK3755403T3 (da) 2018-02-22 2024-09-23 Lilly Co Eli Medikamenttilførselsanordning med et registreret element
US11058605B2 (en) * 2018-03-08 2021-07-13 Flex Ltd. Sterilization fluid path with barrier removal
DK180241B1 (en) 2018-03-12 2020-09-08 Apple Inc User interfaces for health monitoring
MA52168A (fr) * 2018-03-30 2021-02-17 Amgen Inc Inspection de récipient à médicament à base d'appareil de prise de vues
KR20260046525A (ko) 2018-04-11 2026-04-07 인히브릭스 바이오사이언스, 인크. 제한된 cd3 결합을 갖는 다중특이적 폴리펩티드 컨스트럭트 및 관련된 방법 및 용도
CN112004570B (zh) * 2018-04-19 2023-02-21 伊莱利利公司 注射装置的状态感测系统
US11278670B2 (en) * 2018-04-26 2022-03-22 Carefusion 303, Inc. Semi-autonomous hot-swap infusion module
US11317833B2 (en) 2018-05-07 2022-05-03 Apple Inc. Displaying user interfaces associated with physical activities
DK179992B1 (en) 2018-05-07 2020-01-14 Apple Inc. Visning af brugergrænseflader associeret med fysiske aktiviteter
US11664107B2 (en) * 2018-05-08 2023-05-30 Medtronic Minimed, Inc. Intelligent medication delivery systems and methods using a prescription-regulated software application
US20210187199A1 (en) * 2018-05-15 2021-06-24 Quio Technologies Llc Systems and methods for delivering a substance to a living being
KR102785180B1 (ko) * 2018-08-21 2025-03-21 삼성전자주식회사 전자 장치의 제어 방법 및 이를 수행하기 위한 프로그램을 저장하는 컴퓨터 판독 기록 매체
US11324887B2 (en) * 2018-09-14 2022-05-10 Datadose, Llc Reporting syringe
US20250170329A1 (en) 2018-09-14 2025-05-29 Datadose, Llc Dosage management and patient education using an intelligent injection device
WO2020068351A1 (en) * 2018-09-28 2020-04-02 Becton, Dickinson And Company Universal smart cap for pen injectors
ES2926591T3 (es) * 2018-10-03 2022-10-27 Lilly Co Eli Sistemas de detección de estados dentro de un ensamblaje de dispositivo de inyección
EP3632487B1 (en) 2018-10-05 2024-06-12 LTS Device Technologies Ltd Triggering sequence
JP2022504802A (ja) 2018-10-11 2022-01-13 インヒブルクス インコーポレイテッド ５ｔ４シングルドメイン抗体およびその治療組成物
US10705891B2 (en) * 2018-10-26 2020-07-07 International Business Machines Corporation Cognitive agent for persistent multi-platform reminder provision
KR102673821B1 (ko) * 2018-11-08 2024-06-12 메디허브 주식회사 무통 마취 주사장치 및 그 제어방법
KR102623506B1 (ko) * 2018-11-14 2024-01-11 메디허브 주식회사 자동주사장치 및 그 제어방법
CN109472515A (zh) * 2018-11-26 2019-03-15 复旦大学附属中山医院 一种用于保障冷藏药品质量安全的监控方法及系统
EP3897779B1 (en) 2018-12-19 2024-08-07 Eli Lilly and Company Devices and processes for delivery of therapeutic fluids
US12133972B2 (en) 2018-12-19 2024-11-05 Eli Lilly And Company Systems, devices, and processes for delivery of therapeutic fluids
US12164656B2 (en) 2018-12-20 2024-12-10 Id Business Solutions, Inc. Dynamic batch limit validation
AU2020257200A1 (en) 2019-04-17 2021-12-16 Icu Medical, Inc. System for onboard electronic encoding of the contents and administration parameters of IV containers and the secure use and disposal thereof
CA3141608A1 (en) 2019-05-20 2020-11-26 Unomedical A/S Rotatable infusion device and methods thereof
US11228835B2 (en) 2019-06-01 2022-01-18 Apple Inc. User interfaces for managing audio exposure
DK201970534A1 (en) 2019-06-01 2021-02-16 Apple Inc User interfaces for monitoring noise exposure levels
US11234077B2 (en) 2019-06-01 2022-01-25 Apple Inc. User interfaces for managing audio exposure
US11152100B2 (en) 2019-06-01 2021-10-19 Apple Inc. Health application user interfaces
US11209957B2 (en) 2019-06-01 2021-12-28 Apple Inc. User interfaces for cycle tracking
US11094407B2 (en) * 2019-06-13 2021-08-17 International Business Machines Corporation Electronics miniaturization platform for medication verification and tracking
EP3986513A1 (en) * 2019-06-20 2022-04-27 Amgen, Inc Wireless communication enabled drug delivery device and method
US12589209B2 (en) * 2019-06-25 2026-03-31 Shl Medical Ag System with a monitoring device
US12370321B2 (en) 2019-07-01 2025-07-29 Sanofi Awakening electronics in an injection device
WO2021007355A1 (en) * 2019-07-10 2021-01-14 Verily Life Sciences Llc Systems and methods for wearable emergency drug injection devices
US12002588B2 (en) 2019-07-17 2024-06-04 Apple Inc. Health event logging and coaching user interfaces
CN112057705B (zh) * 2019-07-30 2023-04-18 嘉兴森迈医疗科技有限公司 注射装置
JP2022542290A (ja) * 2019-08-01 2022-09-30 アムジエン・インコーポレーテツド 温度測定を備えた薬物送達デバイス及び関連方法
CN114286975A (zh) 2019-09-09 2022-04-05 苹果公司 调查研究用户界面
WO2021051010A1 (en) * 2019-09-11 2021-03-18 Altaviz, Llc Micro-volume injectors with dose guidance and methods for use
JP2022549488A (ja) * 2019-09-25 2022-11-25 ヤンセン ファーマシューティカルズ，インコーポレーテッド 投与量レジメン及び構成成分の互換性を確立するための薬物投与デバイス及びシステム
BR112022005670A2 (pt) * 2019-09-25 2022-08-16 Janssen Pharmaceuticals Inc Dispositivos de administração de fármaco que se comunicam com sistemas externos e/ou com outros dispositivos
AU2020356529A1 (en) 2019-09-25 2022-05-19 Janssen Pharmaceuticals, Inc. Interconnection of drug administration systems
BR112022005657A2 (pt) * 2019-09-25 2022-07-19 Janssen Pharmaceuticals Inc Dispositivo de distribuição de fármaco
BR112022005659A2 (pt) * 2019-09-25 2022-07-19 Janssen Pharmaceuticals Inc Parâmetros de medição associados à administração de fármacos e dispositivos de administração de fármacos que incorpora os mesmos
CN114728133A (zh) * 2019-09-25 2022-07-08 杨森制药公司 药物递送系统和方法
KR102629151B1 (ko) * 2019-10-01 2024-01-29 에스에이치엘 메디컬 아게 캡 어셈블리
CN110841149A (zh) * 2019-12-18 2020-02-28 苏州嘉树医疗科技有限公司 一种低温锁定的自动注射器
JP7459250B2 (ja) * 2019-12-23 2024-04-01 フレセニウス メディカル ケア ホールディングス インコーポレーテッド 赤血球造血刺激因子製剤のための接続された薬物送達システム
US20230081468A1 (en) * 2020-03-11 2023-03-16 Shl Medical Ag System for evaluating a batch of medicament delivery devices, and method
WO2021191322A1 (en) * 2020-03-27 2021-09-30 Sanofi Electronic system for a drug delivery device and drug delivery device
CA3077844A1 (en) 2020-04-03 2021-10-03 Duoject Medical Systems Inc. Method of sanitizing a medical device
DE102020110112A1 (de) * 2020-04-10 2021-10-14 Fresenius Medical Care Deutschland Gmbh Medizinisches Set für Kanülierung
US12102445B2 (en) 2020-05-06 2024-10-01 Janssen Pharmaceuticals, Inc. Monitoring and communicating information using drug administration devices
US11607216B2 (en) 2020-05-06 2023-03-21 Janssen Pharmaceuticals, Inc. Adaptive responses from smart packaging of drug delivery absorbable adjuncts
DK181037B1 (en) 2020-06-02 2022-10-10 Apple Inc User interfaces for health applications
AU2021283914A1 (en) 2020-06-02 2023-01-19 Apple Inc. User interfaces for tracking of physical activity events
WO2021252971A2 (en) 2020-06-12 2021-12-16 Bexson Biomedical, Inc. Systems and devices for controlled drug delivery
US11955210B2 (en) 2020-06-26 2024-04-09 Medtronic Minimed, Inc. Automatic configuration of user-specific data based on networked charger devices
US12136478B2 (en) * 2020-06-26 2024-11-05 Medtronic Minimed, Inc. Automatic configuration of user-specific data based on removal from service
USD955566S1 (en) 2020-07-01 2022-06-21 Zealand Pharma A/S Medicament delivery device
JP7427111B2 (ja) * 2020-07-06 2024-02-02 エスエイチエル・メディカル・アーゲー 薬剤送達装置に取り付けられた補助装置の起動および検出システム
US12232878B1 (en) 2020-08-01 2025-02-25 Apple Inc. Atrial fibrillation user interfaces
WO2022032024A1 (en) * 2020-08-07 2022-02-10 West Pharmaceutical Services, Inc. Injection device and method of indicating an injection status for an injection device
US20220062550A1 (en) * 2020-08-27 2022-03-03 Insulet Corporation Systems and methods for activating drug delivery devices
US11698710B2 (en) 2020-08-31 2023-07-11 Apple Inc. User interfaces for logging user activities
CH716444A2 (de) * 2020-09-09 2021-01-29 Ypsomed Ag Verabreichungssysteme und Methoden zu deren Nutzung.
EP4194027A4 (en) * 2020-09-16 2024-01-24 Eoflow Co., Ltd. NEEDLE ASSEMBLY AND LIQUID MEDICINE INJECTION APPARATUS COMPRISING SAME
WO2022072809A1 (en) 2020-10-02 2022-04-07 SFC Fluidics, Inc. Wearable drug infusion device
US12458751B2 (en) 2020-10-02 2025-11-04 Insulet Corporation Fluid delivery device having multiple penetrating elements
JP7575238B2 (ja) * 2020-10-05 2024-10-29 株式会社東芝 保管履歴管理装置、保管履歴管理プログラム、及び保管履歴管理方法
US11737954B1 (en) 2020-10-06 2023-08-29 Verily Life Sciences Llc Network-connected containers having medication stored therein
WO2022117601A1 (en) * 2020-12-02 2022-06-09 Sanofi User device, system and method for determining a threshold time for an injection device to transition to an operational temperature
US12433512B2 (en) 2020-12-18 2025-10-07 Insulet Corporation Adhesive pad with a metallic coil for securing an on-body medical device
US20220222734A1 (en) * 2020-12-21 2022-07-14 Beta Bionics, Inc. Cloud-connected ambulatory pump integration
JP7717172B2 (ja) 2021-02-09 2025-08-01 ジンマー バイオメット シーエムエフ アンド ソラシック，リミティド ライアビリティ カンパニー 電極を配置するための取り外し可能な分離カニューレ
US11464902B1 (en) 2021-02-18 2022-10-11 Fresenius Kabi Deutschland Gmbh Wearable medicament delivery device with compressible reservoir and method of use thereof
US11872369B1 (en) 2021-02-18 2024-01-16 Fresenius Kabi Deutschland Gmbh Wearable medicament delivery device with leakage and skin contact sensing and method of use thereof
US11311666B1 (en) 2021-02-18 2022-04-26 Fresenius Kabi Deutschland Gmbh Modular wearable medicament delivery device and method of use thereof
US11426523B1 (en) 2021-02-19 2022-08-30 Fresenius Kabi Deutschland Gmbh Drug delivery assembly including a removable cartridge
US11633537B1 (en) 2021-02-19 2023-04-25 Fresenius Kabi Deutschland Gmbh Drug delivery assembly including a pre-filled cartridge
US11344682B1 (en) 2021-02-19 2022-05-31 Fresenius Kabi Deutschland Gmbh Drug supply cartridge with visual use indicator and delivery devices that use the same
US11497847B1 (en) 2021-02-19 2022-11-15 Fresenius Kabi Deutschland Gmbh Wearable injector with adhesive substrate
US11607505B1 (en) 2021-02-19 2023-03-21 Fresenius Kabi Deutschland Gmbh Wearable injector with sterility sensors
US11413394B1 (en) 2021-02-19 2022-08-16 Fresenius Kabi Deutschland Gmbh Display for wearable drug delivery device
US11406755B1 (en) 2021-02-19 2022-08-09 Fresenius Kabi Deutschland Gmbh Sensing fluid flow irregularities in an on-body injector
CA3211462A1 (en) 2021-03-08 2022-09-15 Amgen Inc. Manufacturing process for hollow plunger rod
AU2022233152A1 (en) * 2021-03-10 2023-08-17 Amgen Inc. Drug delivery device
US11849950B2 (en) 2021-03-30 2023-12-26 Cilag Gmbh International Compressible adjuncts with drug dosage control features
US20220313256A1 (en) * 2021-03-30 2022-10-06 Cilag Gmbh International Passively powered packaging for tissue adjuncts
US11864765B2 (en) 2021-03-30 2024-01-09 Cilag Gmbh International Compressible adjuncts with fluid control features
US11896226B2 (en) 2021-03-30 2024-02-13 Cilag Gmbh International Compressible adjuncts with healing-dependent degradation profile
US11627961B2 (en) 2021-03-30 2023-04-18 Cilag Gmbh International Compressible adjuncts with different behavioral zones
US11602341B2 (en) 2021-03-30 2023-03-14 Cilag Gmbh International Compressible adjuncts with drug release features
US12059153B2 (en) 2021-03-30 2024-08-13 Cilag Gmbh International Implantable adjuncts having adjustable degradation profile
US11504125B2 (en) 2021-03-30 2022-11-22 Cilag Gmbh International Tissue thickness compensating adjuncts having regions of differential expansion
US11839374B2 (en) 2021-03-30 2023-12-12 Cilag Gmbh International Compressible adjuncts with drug release features
US11786240B2 (en) * 2021-03-30 2023-10-17 Cilag Gmbh International Using smart packaging in adjusting use of tissue adjuncts
US11850332B2 (en) 2021-03-30 2023-12-26 Cilag Gmbh International Method for treating tissue
JP7763596B2 (ja) 2021-03-31 2025-11-04 三菱重工業株式会社 制御システムおよび制御方法
EP4070832A1 (en) 2021-04-07 2022-10-12 medmix Switzerland AG Keyed connectors
US20240156056A1 (en) * 2021-04-12 2024-05-16 Datamars Sa Improvements In, or Related To, Applicators and Data Acquisition Therefor
CA3216453A1 (en) 2021-04-23 2022-10-27 Unomedical A/S Miniaturized patch pump system
US11504470B1 (en) 2021-04-30 2022-11-22 Fresenius Kabi Deutschland Gmbh Deformable drug reservoir for wearable drug delivery device
US11351300B1 (en) 2021-04-30 2022-06-07 Fresenius Kabl Deutschland GmbH Drug dispensing system with replaceable drug supply cartridges
US11419976B1 (en) 2021-04-30 2022-08-23 Fresenius Kabi Deutschland Gmbh Wearable drug delivery device with pressurized fluid dispensing
US11529459B1 (en) 2021-04-30 2022-12-20 Fresenius Kabi Deutschland Gmbh Wearable injector with adhesive module
US11717608B1 (en) 2021-05-03 2023-08-08 Fresenius Kabi Deutschland Gmbh Drug delivery assembly including an adhesive pad
US11484646B1 (en) 2021-05-04 2022-11-01 Fresenius Kabi Deutschland Gmbh Sealing systems for a reservoir of an on-body injector
US12496398B2 (en) 2021-05-28 2025-12-16 Insulet Corporation Threshold based automatic glucose control response
WO2022251642A1 (en) 2021-05-28 2022-12-01 Insulet Corporation Spring-based status sensors
EP4101482A1 (en) 2021-06-07 2022-12-14 Insulet Corporation Exercise safety prediction based on physiological conditions
WO2023276090A1 (ja) * 2021-06-30 2023-01-05 シンクランド株式会社 経皮投与装置及び経皮投与システム
EP4373542B1 (en) 2021-07-23 2025-04-30 ConvaTec Limited Port with piercing means
US12198803B2 (en) * 2021-07-30 2025-01-14 Eli Lilly And Company Techniques for processing wirelessly broadcast packets from a medical device with dose-related data
KR102662715B1 (ko) * 2021-11-24 2024-05-03 이오플로우(주) 레저버 어셈블리 및 이를 포함하는 약액 주입 장치
US20250166775A1 (en) * 2022-01-31 2025-05-22 Noble International, Llc Interrogatable delivery device and associated status module
GB2612154C (en) * 2022-04-14 2023-11-08 Kilnmark Ltd Medication auto-injectors
EP4285959A1 (en) * 2022-06-01 2023-12-06 Becton, Dickinson and Company Battery-free sensing solution for drug delivery devices
WO2023239948A1 (en) * 2022-06-10 2023-12-14 Alucent Biomedical Inc. Sterilizable nvs catheter and light fiber for use therewith and methods of sterilization
US12508413B2 (en) * 2022-11-11 2025-12-30 Carefusion 303, Inc. Connector coupling assembly
IT202200024792A1 (it) 2022-12-01 2024-06-01 Nuova Ompi S R L Unipersonale Dispositivo di erogazione sottocutanea di un medicamento
US20240211844A1 (en) * 2022-12-21 2024-06-27 Honeywell International Inc. Systems and methods for prescriptive reporting based on metadata triggers
CN121127176A (zh) 2023-02-24 2025-12-12 麦驰斯迪克有限责任公司 用于定位和接入植入端口的系统、方法和设备
US20240416037A1 (en) * 2023-06-16 2024-12-19 Regeneron Pharmaceuticals, Inc. Auto-injector and related methods of use
US20250014705A1 (en) 2023-07-03 2025-01-09 Novus-Medvice Inc. Medical device for controlled dispensing and administration of a drug product prone to misuse and abuse
KR102941756B1 (ko) * 2023-09-26 2026-03-23 주식회사 케어메디 약물 주입 감지 유닛, 이를 포함하는 약물 주입 장치 및 약물 주입 장치의 작동 방법
WO2025227129A2 (en) 2024-04-25 2025-10-30 Starrock Pharma Llc Delivery vehicles comprising proglucagon derived polypeptides and anabolic polypeptides and uses thereof
US20250367381A1 (en) * 2024-05-14 2025-12-04 Gilead Sciences, Inc. Medical injections and related devices and methods
US20250367385A1 (en) * 2024-05-14 2025-12-04 Gilead Sciences, Inc. Medical injections and related devices and methods
WO2026069825A1 (ja) * 2024-09-26 2026-04-02 テルモ株式会社 情報管理システム、情報管理方法、プログラムおよび薬液投与装置
US12576205B1 (en) 2024-11-01 2026-03-17 Datadose, Llc Augmented reality visual guidance system for injectable medication administration and verification

Family Cites Families (462)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6241704B1 (en) 1901-11-22 2001-06-05 Sims Deltec, Inc. Drug pump systems and methods
US3485239A (en) 1967-11-02 1969-12-23 Becton Dickinson Co Self-contained sterile syringe
US4386606A (en) 1979-12-26 1983-06-07 Waters Instruments, Inc. Syringe lock
IN155982B (enExample) 1980-12-31 1985-04-20 Choi Soo Bong
KR850004274A (ko) 1983-12-13 1985-07-11 원본미기재 에리트로포이에틴의 제조방법
US4703008A (en) 1983-12-13 1987-10-27 Kiren-Amgen, Inc. DNA sequences encoding erythropoietin
NZ210501A (en) 1983-12-13 1991-08-27 Kirin Amgen Inc Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
US4559038A (en) 1984-10-19 1985-12-17 Deltec Systems, Inc. Drug delivery system
US4654034A (en) * 1986-02-03 1987-03-31 Masters Edwin J Safety needle cap
US5222362A (en) 1989-01-10 1993-06-29 Maus Daryl D Heat-activated drug delivery system and thermal actuators therefor
US5856298A (en) 1989-10-13 1999-01-05 Amgen Inc. Erythropoietin isoforms
KR100221066B1 (ko) 1989-10-13 1999-10-01 스튜어트 엘.왓트 에리트로포이에틴 유사체와 그를 포함하는 제약학적 조성물
US7217689B1 (en) 1989-10-13 2007-05-15 Amgen Inc. Glycosylation analogs of erythropoietin
AU7323994A (en) * 1993-07-13 1995-02-13 Sims Deltec, Inc. Medical pump and method of programming
CN1057534C (zh) 1993-08-17 2000-10-18 柯瑞英-艾格公司 促红细胞生成素类似物
US6562596B1 (en) 1993-10-06 2003-05-13 Amgen Inc. Tissue inhibitor of metalloproteinase type three (TIMP-3) composition and methods
US5830851A (en) 1993-11-19 1998-11-03 Affymax Technologies N.V. Methods of administering peptides that bind to the erythropoietin receptor
US5773569A (en) 1993-11-19 1998-06-30 Affymax Technologies N.V. Compounds and peptides that bind to the erythropoietin receptor
US5582593A (en) 1994-07-21 1996-12-10 Hultman; Barry W. Ambulatory medication delivery system
US5885574A (en) 1994-07-26 1999-03-23 Amgen Inc. Antibodies which activate an erythropoietin receptor
DE69534530T2 (de) 1994-08-12 2006-07-06 Immunomedics, Inc. Für b-zell-lymphom und leukämiezellen spezifische immunkonjugate und humane antikörper
US5730723A (en) 1995-10-10 1998-03-24 Visionary Medical Products Corporation, Inc. Gas pressured needle-less injection device and method
US5686292A (en) 1995-06-02 1997-11-11 Genentech, Inc. Hepatocyte growth factor receptor antagonist antibodies and uses thereof
US5767078A (en) 1995-06-07 1998-06-16 Johnson; Dana L. Agonist peptide dimers
IE77523B1 (en) 1995-09-11 1997-12-17 Elan Med Tech Medicament delivery device
ZA9610374B (en) 1995-12-11 1997-06-23 Elan Med Tech Cartridge-based drug delivery device
US5879143A (en) 1996-04-26 1999-03-09 Sims Deltec, Inc. Reservoir enclosure adaptors and methods
US6689091B2 (en) 1996-08-02 2004-02-10 Tuan Bui Medical apparatus with remote control
US6355019B1 (en) 1996-12-18 2002-03-12 Science Incorporated Variable rate infusion apparatus with indicator and adjustable rate control
US20010039397A1 (en) 1996-12-18 2001-11-08 Kriesell Marshall S. Fluid delivery apparatus with flow indicator and vial fill
US6183441B1 (en) 1996-12-18 2001-02-06 Science Incorporated Variable rate infusion apparatus with indicator and adjustable rate control
US6176845B1 (en) 1996-12-18 2001-01-23 Science Incorporated Fluid delivery apparatus with flow indicator and vial fill
US5991655A (en) * 1997-03-03 1999-11-23 Drug Delivery Systems, Inc. Iontophoretic drug delivery device and method of manufacturing the same
US6186982B1 (en) * 1998-05-05 2001-02-13 Elan Corporation, Plc Subcutaneous drug delivery device with improved filling system
ES2297889T3 (es) 1997-07-14 2008-05-01 Bolder Biotechnology, Inc. Derivados de hormona de crecimiento y proteinas relacionadas.
US6753165B1 (en) 1999-01-14 2004-06-22 Bolder Biotechnology, Inc. Methods for making proteins containing free cysteine residues
PT986644E (pt) 1997-07-23 2007-01-31 Roche Diagnostics Gmbh Preparação de eritropoietina por activação genética endógena com promotores virais
SE9702872D0 (sv) 1997-08-06 1997-08-06 Pharmacia & Upjohn Ab Automated delivery device and method for its operation
US6171276B1 (en) 1997-08-06 2001-01-09 Pharmacia & Upjohn Ab Automated delivery device and method for its operation
US5957895A (en) 1998-02-20 1999-09-28 Becton Dickinson And Company Low-profile automatic injection device with self-emptying reservoir
US6030086A (en) 1998-03-02 2000-02-29 Becton, Dickinson And Company Flash tube reflector with arc guide
WO1999048546A1 (en) 1998-03-23 1999-09-30 Elan Corporation, Plc Drug delivery device
US6310078B1 (en) 1998-04-20 2001-10-30 Ortho-Mcneil Pharmaceutical, Inc. Substituted amino acids as erythropoietin mimetics
US8480580B2 (en) * 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
DE69933216T2 (de) 1998-06-15 2007-09-20 GTC Biotherapeutics, Inc., Framingham Erythropoietin-analog-menschliches serum-albumin fusionsprotein
US20050181482A1 (en) 2004-02-12 2005-08-18 Meade Harry M. Method for the production of an erythropoietin analog-human IgG fusion proteins in transgenic mammal milk
JP2000042103A (ja) 1998-07-29 2000-02-15 Terumo Corp 薬液注入システム及びその可読メモリ
DE19840965A1 (de) * 1998-09-08 2000-03-09 Disetronic Licensing Ag Vorrichtung zur Selbstverabreichung eines Produktfluids
MEP42108A (en) 1998-10-23 2011-02-10 Kiren Amgen Inc Dimeric thrombopoietin peptide mimetics binding to mp1 receptor and having thrombopoietic activity
AU774989B2 (en) 1998-10-23 2004-07-15 Amgen, Inc. Methods and compositions for the prevention and treatment of anemia
US7766873B2 (en) 1998-10-29 2010-08-03 Medtronic Minimed, Inc. Method and apparatus for detecting occlusions in an ambulatory infusion pump
US7621893B2 (en) 1998-10-29 2009-11-24 Medtronic Minimed, Inc. Methods and apparatuses for detecting occlusions in an ambulatory infusion pump
ATE481487T1 (de) 1998-11-27 2010-10-15 Ucb Sa Zusammensetzungen und verfahren zur erhöhung der knochenmineralisierung
EP1006184A1 (en) 1998-12-03 2000-06-07 F. Hoffmann-La Roche Ag IGF-1 receptor interacting proteins (IIPs) genes coding therefor and uses thereof
EP1169352A4 (en) 1999-04-14 2005-05-04 Smithkline Beecham Corp ANTIBODY AGAINST THE ERYTHROPOIETIN RECEPTOR
US7297680B2 (en) 1999-04-15 2007-11-20 Crucell Holland B.V. Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content
CZ299516B6 (cs) 1999-07-02 2008-08-20 F. Hoffmann-La Roche Ag Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem
EP1226243A2 (en) 1999-10-22 2002-07-31 Millennium Pharmaceuticals, Inc. Nucleic acid molecules derived from rat brain and programmed cell death models
CA2391080A1 (en) 1999-11-12 2001-05-25 Merck Patent Gesellschaft Mit Beschraenkter Haftung Erythropoietin forms with improved properties
US20050202538A1 (en) 1999-11-12 2005-09-15 Merck Patent Gmbh Fc-erythropoietin fusion protein with improved pharmacokinetics
US6562001B2 (en) 2000-01-21 2003-05-13 Medtronic Minimed, Inc. Microprocessor controlled ambulatory medical apparatus with hand held communication device
GB2375113B (en) 2000-01-21 2004-10-20 Biovex Ltd A modified, oncolytic, non-laboratory HSV strain and its use in treating cancer
US20010049608A1 (en) * 2000-01-25 2001-12-06 Hochman Mark N. Injection tracking and management system
AUPQ599700A0 (en) 2000-03-03 2000-03-23 Super Internet Site System Pty Ltd On-line geographical directory
US6586398B1 (en) 2000-04-07 2003-07-01 Amgen, Inc. Chemically modified novel erythropoietin stimulating protein compositions and methods
PT1274728E (pt) 2000-04-21 2008-06-20 Amgen Inc Métodos e composições para a prevenção e tratamento de anemia
US6756480B2 (en) 2000-04-27 2004-06-29 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
US6968179B1 (en) 2000-07-27 2005-11-22 Microsoft Corporation Place specific buddy list services
US7078376B1 (en) 2000-08-11 2006-07-18 Baxter Healthcare S.A. Therapeutic methods for treating subjects with a recombinant erythropoietin having high activity and reduced side effects
GB2366705B (en) 2000-08-29 2004-07-14 Motorola Inc Communications system, communications unit and method of operation
US6740059B2 (en) * 2000-09-08 2004-05-25 Insulet Corporation Devices, systems and methods for patient infusion
KR20030057529A (ko) 2000-09-08 2003-07-04 그리폰 테라퓨틱스, 인코포레이티드 합성 적혈구생성 자극 단백질
AU2001289589A1 (en) * 2000-09-22 2002-04-02 Novo-Nordisk A/S A medication delivery device
CN1476566A (zh) 2000-10-04 2004-02-18 病人输液系统的数据采集装置
US7271689B1 (en) 2000-11-22 2007-09-18 Fonar Corporation Magnet structure
EP1345628B1 (en) 2000-12-20 2011-04-13 F. Hoffmann-La Roche AG Conjugates of erythropoietin (epo) with polyethylene glycol (peg)
ME00502B (me) 2001-01-05 2011-10-10 Amgen Fremont Inc Antitjela za insulinu sličan receptor faktora i rasta
WO2002056822A1 (en) * 2001-01-19 2002-07-25 Raimo Juselius Device for monitoring the administration of doses and system for monitoring the administration of doses
CA2443373A1 (en) 2001-04-04 2002-10-31 Genodyssee New polynucleotides and polypeptides of the erythropoietin gene
US20040035491A1 (en) 2002-08-26 2004-02-26 Penjet Corporation Method and apparatus for needle-less injection with a degassed fluid
US6817986B2 (en) * 2001-04-13 2004-11-16 Avant Medical Corp. Jet injector with data logging system for use in compliance and dose monitoring programs
DK1385882T3 (da) 2001-05-11 2008-02-11 Amgen Inc Peptider og relaterede molekyler, der binder til TALL-1
US8034026B2 (en) 2001-05-18 2011-10-11 Deka Products Limited Partnership Infusion pump assembly
US20120209197A1 (en) 2002-01-04 2012-08-16 Lanigan Richard J Infusion pump assembly
EP2295081B1 (en) 2001-06-26 2018-10-31 Amgen Inc. Antibodies to OPGL
US6900292B2 (en) 2001-08-17 2005-05-31 Lee-Hwei K. Sun Fc fusion proteins of human erythropoietin with increased biological activities
US7247304B2 (en) 2001-08-23 2007-07-24 Genmab A/S Methods of treating using anti-IL-15 antibodies
RS51829B (sr) 2001-08-23 2012-02-29 Genmab A/S. Ljudska antitela specifična za interleukin 15 (il-15)
US6930086B2 (en) 2001-09-25 2005-08-16 Hoffmann-La Roche Inc. Diglycosylated erythropoietin
DE60230888D1 (de) 2001-09-26 2009-03-05 Novo Nordisk As Modulare vorrichtung zur verabreichung von medikamenten
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7138370B2 (en) 2001-10-11 2006-11-21 Amgen Inc. Specific binding agents of human angiopoietin-2
US7521053B2 (en) 2001-10-11 2009-04-21 Amgen Inc. Angiopoietin-2 specific binding agents
US7429258B2 (en) 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US7204823B2 (en) 2001-12-19 2007-04-17 Medtronic Minimed, Inc. Medication delivery system and monitor
WO2003055526A2 (en) 2001-12-21 2003-07-10 Maxygen Aps Erythropoietin conjugates
US7241444B2 (en) 2002-01-18 2007-07-10 Pierre Fabre Medicament Anti-IGF-IR antibodies and uses thereof
SI1461359T1 (sl) 2002-01-18 2007-06-30 Pf Medicament Nova anti IGF-IR protitelesa in njihova uporaba
GB0202252D0 (en) 2002-01-31 2002-03-20 Oxford Biomedica Ltd Anemia
WO2003064664A1 (en) 2002-01-31 2003-08-07 Oxford Biomedica (Uk) Limited Physiologically regulated erythropoietin- exprressing vector for the treatment of anaemia
US7004928B2 (en) 2002-02-08 2006-02-28 Rosedale Medical, Inc. Autonomous, ambulatory analyte monitor or drug delivery device
AU2003208305A1 (en) 2002-02-18 2003-09-04 Danfoss A/S Device for administering of medication in fluid form
US6878136B2 (en) 2002-02-28 2005-04-12 Medical Product Specialists Huber needle with anti-rebound safety mechanism
US20050027264A1 (en) 2002-02-28 2005-02-03 Fleury Michael T. Huber needle with anti-rebound safety mechanism
US7033338B2 (en) 2002-02-28 2006-04-25 Smiths Medical Md, Inc. Cartridge and rod for axially loading medication pump
US6918894B2 (en) 2002-02-28 2005-07-19 Medical Product Specialists Huber needle with anti-rebound safety mechanism
ATE363541T1 (de) 2002-03-26 2007-06-15 Lek Tovarna Farmacevtskih Verfahren für die herstellung eines gewünschten profils von erythropoietin glyko-isoformen
EP1572079A4 (en) 2002-03-29 2006-09-06 Centocor Inc MAMMAL-CDR MIMETIC BODIES, COMPOSITIONS, PROCESSES AND APPLICATION PURPOSES
BRPI0308946B1 (pt) 2002-03-29 2016-08-30 Kumiai Chemical Industry Co ácido nucleico, proteína, vetor recombinante, bactéria, processos para cultivar planta que apresenta o referido ácido nucleico, para cultivar planta que apresenta a referida proteína, para seleção de célula transformante que apresenta o referido ácido nucleico e para selecionar célula transformante que apresenta a referida proteína
US6656159B2 (en) 2002-04-23 2003-12-02 Insulet Corporation Dispenser for patient infusion device
US6656158B2 (en) 2002-04-23 2003-12-02 Insulet Corporation Dispenser for patient infusion device
US6960192B1 (en) * 2002-04-23 2005-11-01 Insulet Corporation Transcutaneous fluid delivery system
US20040009902A1 (en) 2002-05-13 2004-01-15 Irving Boime CTP extended erythropoietin
EP1506286B1 (en) 2002-05-24 2014-03-19 Merck Sharp & Dohme Corp. Neutralizing human anti-igfr antibody
US7538195B2 (en) 2002-06-14 2009-05-26 Immunogen Inc. Anti-IGF-I receptor antibody
US8034904B2 (en) 2002-06-14 2011-10-11 Immunogen Inc. Anti-IGF-I receptor antibody
US7241733B2 (en) 2002-06-28 2007-07-10 Centocor, Inc. Mammalian EPO mimetic CH1 deleted mimetibodies, compositions, methods and uses
CA2490409A1 (en) 2002-06-28 2004-01-08 Centocor, Inc. Mammalian ch1 deleted mimetibodies, compositions, methods and uses
EP2286857A1 (en) 2002-07-02 2011-02-23 Panasonic Corporation Automatic administration instrument for medical use
US7018360B2 (en) * 2002-07-16 2006-03-28 Insulet Corporation Flow restriction system and method for patient infusion device
AU2003246486A1 (en) 2002-07-19 2004-02-09 Cangene Corporation Pegylated erythropoietic compounds
TW200413406A (en) 2002-08-26 2004-08-01 Kirin Brewery Peptides and drugs containing the same
KR101317045B1 (ko) 2002-09-06 2013-10-16 암젠 인코포레이티드 치료학적 인체 항-ｉｌ-1ｒ1 모노클로날 항체
WO2005025606A1 (en) 2003-09-09 2005-03-24 Warren Pharmaceuticals, Inc. Long acting erythropoietins that maintain tissue protective activity of endogenous erythropoietin
BR0314227A (pt) 2002-09-11 2005-10-25 Fresenius Kabi De Gmbh Derivados de amido de hidroxialquila
CN1723053A (zh) 2002-09-12 2006-01-18 儿童医院医疗中心 无痛药物注射的方法和设备
US6919426B2 (en) 2002-09-19 2005-07-19 Amgen Inc. Peptides and related molecules that modulate nerve growth factor activity
US7128727B2 (en) 2002-09-30 2006-10-31 Flaherty J Christopher Components and methods for patient infusion device
US7144384B2 (en) 2002-09-30 2006-12-05 Insulet Corporation Dispenser components and methods for patient infusion device
US20050075670A1 (en) 2002-10-07 2005-04-07 Henrik Bengtsson Signal device with electro-muscle stimulation feature
US20040071694A1 (en) 2002-10-14 2004-04-15 Devries Peter J. Erythropoietin receptor binding antibodies
TWI320716B (en) 2002-10-14 2010-02-21 Abbott Lab Erythropoietin receptor binding antibodies
US7396913B2 (en) 2002-10-14 2008-07-08 Abbott Laboratories Erythropoietin receptor binding antibodies
WO2004034988A2 (en) 2002-10-16 2004-04-29 Amgen Inc. Human anti-ifn-ϝ neutralizing antibodies as selective ifn-ϝ pathway inhibitors
US20040091961A1 (en) 2002-11-08 2004-05-13 Evans Glen A. Enhanced variants of erythropoietin and methods of use
BR0317538A (pt) 2002-12-20 2005-11-29 Amgen Inc Agente ligante, sequência de polinucleotìdeo, vetor de expressão, célula hospedeira, composição farmacêutica, e, métodos de inibir a atividade de miostatina, de aumentar a massa muscular magra e a razão de massa muscular magra para gordura, de tratar uma doença de emaciação muscular e um distúrbio metabólico relacionado com miostatina em um indivìduo, de detectar e medir miostatina em uma amostra, e, de diagnosticar um distúrbio relacionado com miostatina em um indivìduo
RU2004132832A (ru) * 2003-03-06 2005-08-27 Лайфскен, Инк. (Us) Система и способ для прокалывания дермальной ткани
JP2007528201A (ja) 2003-03-14 2007-10-11 ファルマシア・コーポレーション 癌治療のためのｉｇｆ−ｉ受容体に対する抗体
ES2383014T3 (es) 2003-04-02 2012-06-15 F. Hoffmann-La Roche Ag Anticuerpos contra el factor I de crecimiento similar a insulina y usos de los mismos
WO2004093648A2 (en) 2003-04-18 2004-11-04 Insulet Corporation User interface for infusion pump remote controller and method of using the same
US7220410B2 (en) 2003-04-18 2007-05-22 Galaxy Biotech, Llc Monoclonal antibodies to hepatocyte growth factor
KR20060005389A (ko) 2003-04-23 2006-01-17 바소겐 아일랜드 리미티드 주사 시스템
CA2524305C (en) 2003-05-01 2015-12-08 Imclone Systems Incorporated Fully human antibodies directed against the human insulin-like growth factor-1 receptor
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
CN1820024B (zh) 2003-05-12 2011-06-22 阿费麦克斯公司 新的聚(乙二醇)修饰的化合物及其用途
ATE428727T1 (de) 2003-05-12 2009-05-15 Affymax Inc Neue, an den erythropoietinrezeptor bindende peptide
AU2004238868B2 (en) 2003-05-12 2010-01-21 Affymax, Inc. Peptides that bind to the erythropoietin receptor
US7074755B2 (en) 2003-05-17 2006-07-11 Centocor, Inc. Erythropoietin conjugate compounds with extended half-lives
CA2527665A1 (en) 2003-05-30 2004-12-16 Centocor, Inc. Formation of novel erythropoietin conjugates using transglutaminase
DE10325106A1 (de) 2003-06-03 2004-12-30 Disetronic Licensing Ag Vorrichtung und Verfahren zur Erkennung eines Benutzers eines medizinischen Geräts
WO2005001136A1 (en) 2003-06-04 2005-01-06 Irm Llc Methods and compositions for modulating erythropoietin expression
WO2005000384A1 (en) 2003-06-05 2005-01-06 University Of Florida Auto-injection devices and methods for intramuscular administration of medications
US20050020980A1 (en) 2003-06-09 2005-01-27 Yoshio Inoue Coupling system for an infusion pump
AR046071A1 (es) 2003-07-10 2005-11-23 Hoffmann La Roche Anticuerpos contra el receptor i del factor de crecimiento de tipo insulinico y los usos de los mismos
AR045056A1 (es) 2003-07-15 2005-10-12 Amgen Inc Anticuerpos anti-ngf humanos neutralizantes como inhibidores selectivos de la via de ngf
WO2005007223A2 (en) 2003-07-16 2005-01-27 Sasha John Programmable medical drug delivery systems and methods for delivery of multiple fluids and concentrations
TWI476206B (zh) 2003-07-18 2015-03-11 Amgen Inc 對肝細胞生長因子具專一性之結合劑
US20050019914A1 (en) 2003-07-24 2005-01-27 Aventis Pharma Deutschland Gmbh Perfusion process for producing erythropoietin
GB0317511D0 (en) 2003-07-25 2003-08-27 Biovex Ltd Viral vectors
MXPA06001373A (es) 2003-08-12 2006-05-15 Becton Dickinson Co Dispositivo de infusion similar a un parche.
EP1663278A4 (en) 2003-08-28 2009-07-29 Biorexis Pharmaceutical Corp EPO MIMETIC PEPTIDES AND FUSION PROTEINS
UA89481C2 (uk) 2003-09-30 2010-02-10 Центокор, Инк. Еритропоетинові міметичні шарнірно-серцевинні міметитіла людини, композиції, способи та застосування
EP1687452A4 (en) 2003-09-30 2008-08-06 Centocor Inc HUMAN HINGE-CORE MIMETICORPS, COMPOSITIONS, METHODS AND APPLICATIONS THEREOF
KR20060099520A (ko) * 2003-10-21 2006-09-19 노보 노르디스크 에이/에스 의료용 피부 장착 장치
SG148163A1 (en) * 2003-11-06 2008-12-31 Lifescan Inc Drug delivery pen with event notification means
BRPI0416603A (pt) 2003-11-07 2007-01-30 Immunex Corp anticorpo que se liga ao receptor interleucina-4 (il-4) humano
TW200526684A (en) 2003-11-21 2005-08-16 Schering Corp Anti-IGFR1 antibody therapeutic combinations
EP1694347B1 (en) 2003-11-24 2013-11-20 BioGeneriX AG Glycopegylated erythropoietin
US8633157B2 (en) 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
WO2005058967A2 (en) 2003-12-16 2005-06-30 Pierre Fabre Medicament Novel anti-insulin/igf-i hybrid receptor or anti-insulin/igf-i hybrid receptor and igf-ir antibodies and uses thereof
EP1548031A1 (en) 2003-12-22 2005-06-29 Dubai Genetics FZ-LLC Nature-identical erythropoietin
RU2370276C2 (ru) 2003-12-31 2009-10-20 Мерк Патент Гмбх Fc-ЭРИТРОПОЭТИН СЛИТЫЙ БЕЛОК С УЛУЧШЕННОЙ ФАРМАКОКИНЕТИКОЙ
WO2005065239A2 (en) 2003-12-31 2005-07-21 Centocor, Inc. Novel recombinant proteins with n-terminal free thiol
US7423139B2 (en) 2004-01-20 2008-09-09 Insight Biopharmaceuticals Ltd. High level expression of recombinant human erythropoietin having a modified 5′-UTR
WO2005070451A1 (en) 2004-01-22 2005-08-04 Zafena Aktiebolag Pharmaceutical composition comprising non-glycosylated erythropoietin
ES2555125T3 (es) 2004-02-18 2015-12-29 Ares Trading S.A. Dispositivo manual de inyección controlada electrónicamente para inyectar medicamentos líquidos
WO2005084711A1 (en) 2004-03-02 2005-09-15 Chengdu Institute Of Biological Products A pegylated recombinant erythropoietin that has in vivo activity
WO2005092369A2 (en) 2004-03-11 2005-10-06 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyethyl starch and erythropoietin
WO2005094879A2 (en) 2004-03-23 2005-10-13 Amgen, Inc. Monoclonal antibodies specific for human ox40l (cd 134l)
US20050227289A1 (en) 2004-04-09 2005-10-13 Reilly Edward B Antibodies to erythropoietin receptor and uses thereof
CA2563874A1 (en) 2004-04-23 2005-11-03 Cambridge Antibody Technology Limited Erythropoietin protein variants
US7220245B2 (en) 2004-05-26 2007-05-22 Kriesel Marshall S Infusion apparatus
WO2006002646A2 (en) 2004-07-07 2006-01-12 H. Lundbeck A/S Novel carbamylated epo and method for its production
FR2873699B1 (fr) 2004-07-29 2009-08-21 Pierre Fabre Medicament Sa Nouveaux anticorps anti igf ir rt leurs utilisations
US20060073563A1 (en) 2004-09-02 2006-04-06 Xencor, Inc. Erythropoietin derivatives with altered immunogenicity
EP1640029A1 (en) * 2004-09-24 2006-03-29 Novo Nordisk A/S Injection device with cap
DE602005018518D1 (de) 2004-10-21 2010-02-04 Novo Nordisk As Injektionsvorrichtung mit einem prozessor zur sammlung von ausstossinformationen
CA2586915A1 (en) 2004-11-10 2006-05-18 Aplagen Gmbh Molecules which promote hematopoiesis
MY146381A (en) 2004-12-22 2012-08-15 Amgen Inc Compositions and methods relating relating to anti-igf-1 receptor antibodies
WO2006067217A2 (en) 2004-12-22 2006-06-29 Novo Nordisk A/S Sensor system and method for detecting problems with mounting of skin mountable medical devices
US7906625B2 (en) 2005-01-24 2011-03-15 Amgen Inc. Humanized anti-amyloid antibody
US8361026B2 (en) 2005-02-01 2013-01-29 Intelliject, Inc. Apparatus and methods for self-administration of vaccines and other medicaments
GB2451769B (en) * 2005-02-01 2009-12-09 Intelliject Llc Devices, systems, and methods for medicament delivery
US8231573B2 (en) * 2005-02-01 2012-07-31 Intelliject, Inc. Medicament delivery device having an electronic circuit system
GB2462209A (en) 2005-02-11 2010-02-03 Stryker Corp A fluid delivery system with fluid flow detection means
WO2006108304A1 (en) 2005-04-11 2006-10-19 Disetronic Licensing Ag Web-enabled portable medical device
US7592429B2 (en) 2005-05-03 2009-09-22 Ucb Sa Sclerostin-binding antibody
US7618393B2 (en) 2005-05-03 2009-11-17 Pharmajet, Inc. Needle-less injector and method of fluid delivery
WO2006123329A2 (en) 2005-05-17 2006-11-23 Medingo Ltd. Disposable dispenser for patient infusion
US20060263839A1 (en) 2005-05-17 2006-11-23 Isense Corporation Combined drug delivery and analyte sensor apparatus
EP1893256B1 (en) 2005-06-16 2012-09-26 Novo Nordisk A/S Method and apparatus for assisting patients in self administration of medication
CA2612449A1 (en) 2005-06-17 2006-12-28 Imclone Systems Incorporated Receptor antagonists for treatment of metastatic bone cancer
EP1904131A2 (en) 2005-06-21 2008-04-02 Eli Lilly And Company Apparatus and method for injecting a pharmaceutical
WO2007000328A1 (en) 2005-06-27 2007-01-04 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Antibodies that bind to an epitope on insulin-like growth factor 1 receptor and uses thereof
EP2397498A3 (en) 2005-07-18 2013-11-27 Amgen, Inc Human anti-B7RP1 neutralizing antibodies
FR2888850B1 (fr) 2005-07-22 2013-01-11 Pf Medicament Nouveaux anticorps anti-igf-ir et leurs applications
US20070038181A1 (en) 2005-08-09 2007-02-15 Alexander Melamud Method, system and device for delivering a substance to tissue
US20070060870A1 (en) 2005-08-16 2007-03-15 Tolle Mike Charles V Controller device for an infusion pump
PE20071101A1 (es) 2005-08-31 2007-12-21 Amgen Inc Polipeptidos y anticuerpos
WO2007035563A2 (en) 2005-09-19 2007-03-29 Lifescan, Inc. Malfunction detection via pressure pulsation
DE102005052502A1 (de) 2005-11-03 2007-05-16 Tecpharma Licensing Ag Autoinjektor-Aktivierung Auslöseelement
US7935104B2 (en) 2005-11-07 2011-05-03 Medingo, Ltd. Systems and methods for sustained medical infusion and devices related thereto
US20150057615A1 (en) 2005-11-08 2015-02-26 Asante Solutions Infusion Pump System
CA2631435C (en) * 2005-12-20 2014-08-12 Antares Pharma, Inc. Needle-free injection device
HRP20170188T1 (hr) * 2006-01-31 2017-04-07 Ares Trading S.A. Naprava za injekciju s kapacitivnim senzorom blizine
CN104162200B (zh) 2006-02-09 2018-03-27 德卡产品有限公司 外围系统
US9839743B2 (en) 2006-02-09 2017-12-12 Deka Products Limited Partnership Apparatus, system and method for fluid delivery
GB0603683D0 (en) 2006-02-23 2006-04-05 Novartis Ag Organic compounds
US9008764B2 (en) 2006-03-20 2015-04-14 Novo Nordisk A/S Determination of position of injection needle
MX2008012446A (es) 2006-03-29 2008-11-12 Intelliject Llc Dispositivos, sistemas y metodos para administracion de medicamentos.
TWI395754B (zh) 2006-04-24 2013-05-11 Amgen Inc 人類化之ｃ-ｋｉｔ抗體
US8348885B2 (en) * 2006-04-28 2013-01-08 Medtronic Minimed, Inc. Remote monitoring for networked fluid infusion systems
US8267905B2 (en) * 2006-05-01 2012-09-18 Neurosystec Corporation Apparatus and method for delivery of therapeutic and other types of agents
US7871399B2 (en) 2006-05-17 2011-01-18 Alcon Research, Ltd. Disposable ophthalmic injection device
US7851438B2 (en) 2006-05-19 2010-12-14 GlycoFi, Incorporated Erythropoietin compositions
US20070282269A1 (en) 2006-05-31 2007-12-06 Seattle Medical Technologies Cannula delivery apparatus and method for a disposable infusion device
WO2007149514A2 (en) 2006-06-19 2007-12-27 Corium International, Inc. Methods, devices, and kits for microjet drug delivery
MX2008016335A (es) * 2006-06-30 2009-01-21 Abbott Biotech Ltd Dispositivo automatico de inyeccion.
WO2008008281A2 (en) 2006-07-07 2008-01-17 Proteus Biomedical, Inc. Smart parenteral administration system
US7871393B2 (en) 2006-07-13 2011-01-18 Henry Schein, Inc. Injection device with reporting ability
US8044778B2 (en) 2007-07-12 2011-10-25 Henry Schein, Inc. Injection device and case with reporting ability
US20080160492A1 (en) 2006-08-08 2008-07-03 Insulet Corporation Interactive training system and method
CL2007002567A1 (es) 2006-09-08 2008-02-01 Amgen Inc Proteinas aisladas de enlace a activina a humana.
JP2010504798A (ja) 2006-09-29 2010-02-18 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 経皮ドラッグデリバリーのための電気的に活性化されたゲル配列
US20080234625A1 (en) 2006-10-16 2008-09-25 Bruno Dacquay Fuse Assembly For Single Use Medical Device
US20110077614A1 (en) 2006-10-19 2011-03-31 Ofer Shay Device and method for patient activated bolus administration
US20100040610A1 (en) 2006-11-07 2010-02-18 Ayesha Sitlani Antagonists of pcsk9
US20100040611A1 (en) 2006-11-07 2010-02-18 Sparrow Carl P Antagonists of pcsk9
WO2008057459A2 (en) 2006-11-07 2008-05-15 Merck & Co., Inc. Antagonists of pcsk9
WO2008057458A2 (en) 2006-11-07 2008-05-15 Merck & Co., Inc. Antagonists of pcsk9
US20080119705A1 (en) 2006-11-17 2008-05-22 Medtronic Minimed, Inc. Systems and Methods for Diabetes Management Using Consumer Electronic Devices
JP5059119B2 (ja) 2006-12-14 2012-10-24 シェーリング コーポレイション 操作された抗ｔｓｌｐ抗体
US7946985B2 (en) 2006-12-29 2011-05-24 Medtronic Minimed, Inc. Method and system for providing sensor redundancy
IL185737A0 (en) 2007-09-05 2008-01-06 Sindolor Medical Ltd A device and method for piercing a patient's skin with an injector whilst reducing pain caused by the piercing
WO2008091838A2 (en) 2007-01-22 2008-07-31 Intelliject, Inc. Medical injector with compliance tracking and monitoring
MX2009009999A (es) 2007-03-19 2010-03-17 Insuline Medical Ltd Metodo y dispositivo para suministro de farmacos.
EP2136863A2 (en) 2007-03-19 2009-12-30 Insuline Medical Ltd. Device for drug delivery and associated connections thereto
WO2009081262A1 (en) * 2007-12-18 2009-07-02 Insuline Medical Ltd. Drug delivery device with sensor for closed-loop operation
EP3865161A1 (de) 2007-03-22 2021-08-18 Ypsomed AG Injektionsvorrichtung mit gesteuertem nadelrückzug
EP2131894A1 (en) 2007-03-27 2009-12-16 Koninklijke Philips Electronics N.V. Drug administration based on a patient's activity status measured by acceleration sensors
EA200901376A1 (ru) 2007-04-13 2010-12-30 Новартис Аг Молекулы и способы модуляции пропротеинконвертазы субтилизинового/кексинового типа 9(pcsk9)
WO2008139464A1 (en) 2007-05-10 2008-11-20 Nilimedix Ltd Infusion set self-occlusion mechanism
US7981102B2 (en) 2007-05-21 2011-07-19 Asante Solutions, Inc. Removable controller for an infusion pump
US7794426B2 (en) 2007-05-21 2010-09-14 Asante Solutions, Inc. Infusion pump system with contamination-resistant features
CN102027012A (zh) 2007-06-20 2011-04-20 Irm责任有限公司 用于治疗变应性疾病的方法和组合物
CN101801438B (zh) 2007-07-20 2013-08-07 梅丁格有限公司 可手动操作的便携式输注设备
EP2022518A1 (en) 2007-08-07 2009-02-11 Sensile Pat AG Modular drug delivery device for administering discrete doses of a medicament
US8683381B2 (en) 2007-08-09 2014-03-25 Alfred E. Mann Foundation For Scientific Research Drug delivery safety system
US7982016B2 (en) 2007-09-10 2011-07-19 Amgen Inc. Antigen binding proteins capable of binding thymic stromal lymphopoietin
WO2009039203A2 (en) 2007-09-17 2009-03-26 Satish Sundar High precision infusion pump controller
US20090082730A1 (en) 2007-09-24 2009-03-26 Li Nguyen Needle injection assembly
US7771391B2 (en) 2007-09-28 2010-08-10 Calibra Medical, Inc. Disposable infusion device with snap action actuation
US8231572B2 (en) 2007-09-28 2012-07-31 Calibra Medical, Inc. Disposable infusion device with reuse lock-out
TWI451862B (zh) 2007-10-09 2014-09-11 Alcon Res Ltd 用於眼睛注射的熱係數驅動藥丸尺寸
US20090099525A1 (en) 2007-10-11 2009-04-16 Animas Corporation Drug Delivery System with Breakaway Plunger Extractor
NZ584902A (en) 2007-10-26 2012-03-30 Schering Corp Anti-pcsk9 and methods for treating lipid and cholesterol disorders
WO2009059187A1 (en) * 2007-11-02 2009-05-07 University Of Virginia Patent Foundation Predictive control based system and method for control of insulin delivery in diabetes using glucose sensing
US7875022B2 (en) 2007-12-12 2011-01-25 Asante Solutions, Inc. Portable infusion pump and media player
US7976505B2 (en) 2007-12-19 2011-07-12 Calibra Medical, Inc. Disposable infusion device negative pressure filling apparatus and method
US10188787B2 (en) 2007-12-31 2019-01-29 Deka Products Limited Partnership Apparatus, system and method for fluid delivery
CN101254322B (zh) 2008-01-07 2010-05-12 杨力 便携式智能胰岛素治疗泵
US20090177142A1 (en) 2008-01-09 2009-07-09 Smiths Medical Md, Inc Insulin pump with add-on modules
EP2359880A3 (en) 2008-02-04 2011-09-21 Nilimedix Ltd. Drug delivery system with wireless monitor
AR070316A1 (es) 2008-02-07 2010-03-31 Merck & Co Inc Antagonistas de pcsk9 (proproteina subtilisina-kexina tipo 9)
AR070315A1 (es) 2008-02-07 2010-03-31 Merck & Co Inc Anticuerpos 1b20 antagonistas de pcsk9
US8540673B2 (en) 2008-03-18 2013-09-24 Calibra Medical, Inc. Disposable infusion device with actuation lock-out
WO2009120692A2 (en) 2008-03-25 2009-10-01 Animal Innovations, Inc. Syringe mechanism for detecting syringe status
CN101977645B (zh) * 2008-04-10 2013-01-30 松下电器产业株式会社 给药装置
US20090259194A1 (en) 2008-04-11 2009-10-15 Raffi Pinedjian Keyed Safety Cap and Receptacle for Two Piece Injection Device
US9974904B2 (en) * 2008-05-20 2018-05-22 Avant Medical Corp. Autoinjector system
US9295786B2 (en) * 2008-05-28 2016-03-29 Medtronic Minimed, Inc. Needle protective device for subcutaneous sensors
US7976500B2 (en) 2008-06-26 2011-07-12 Calibra Medical, Inc. Disposable infusion device with redundant valved safety
US8128597B2 (en) 2008-06-26 2012-03-06 Calibra Medical, Inc. Disposable infusion device with cannula port cover
US8231577B2 (en) 2008-06-26 2012-07-31 Calibra Medical, Inc. Disposable infusion device with automatically releasable cannula driver
GB0814747D0 (en) 2008-08-13 2008-09-17 Owen Mumford Ltd Autoinjection devices
AU2009290976B2 (en) * 2008-09-10 2015-05-28 F. Hoffmann-La Roche Ag Delivery device for use with a therapeutic drug
TWI516501B (zh) 2008-09-12 2016-01-11 禮納特神經系統科學公司 Ｐｃｓｋ９拮抗劑類
WO2015048803A2 (en) 2013-09-30 2015-04-02 Medimop Medical Projects Ltd. Stabilized pen injector
US9427529B2 (en) 2008-09-15 2016-08-30 Medimop Medical Projects Ltd. Safeguard mechanism for autoinjector needle
WO2010031059A2 (en) * 2008-09-15 2010-03-18 Deka Products Limited Partnership Systems and methods for fluid delivery
CN102170929B (zh) * 2008-10-01 2014-03-26 诺沃—诺迪斯克有限公司 具有监测设备的医疗组件
US20090192443A1 (en) * 2008-10-06 2009-07-30 Collins Jr James F Ophthalmic fluid delivery device and method of operation
US8016789B2 (en) 2008-10-10 2011-09-13 Deka Products Limited Partnership Pump assembly with a removable cover assembly
US8223028B2 (en) 2008-10-10 2012-07-17 Deka Products Limited Partnership Occlusion detection system and method
US8262616B2 (en) 2008-10-10 2012-09-11 Deka Products Limited Partnership Infusion pump assembly
US8597570B2 (en) 2008-11-04 2013-12-03 Panasonic Corporation Measurement device, insulin infusion device, measurement method, method for controlling insulin infusion device, and program
JP5562969B2 (ja) 2008-11-06 2014-07-30 ノボ・ノルデイスク・エー／エス 電子的に支援された薬剤送達装置
US20100121274A1 (en) 2008-11-12 2010-05-13 Baxter International Inc. Prefillable constant pressure ambulatory infusion pump
JO3672B1 (ar) 2008-12-15 2020-08-27 Regeneron Pharma أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9).
US9370621B2 (en) 2008-12-16 2016-06-21 Medtronic Minimed, Inc. Needle insertion systems and methods
JO3382B1 (ar) 2008-12-23 2019-03-13 Amgen Inc أجسام مضادة ترتبط مع مستقبل cgrp بشري
CN104888316B (zh) 2009-02-27 2017-08-08 生命扫描有限公司 给药系统
US8496623B2 (en) 2009-03-02 2013-07-30 Becton, Dickinson And Company Bi-directional cannula feature capture mechanism
US8548623B2 (en) 2009-03-18 2013-10-01 Acelrx Pharmaceuticals, Inc. Storage and dispensing devices for administration of oral transmucosal dosage forms
DE102009002537A1 (de) 2009-04-21 2010-10-28 Robert Bosch Gmbh Medizinische, von einem Patienten zu benutzende Vorrichtung
US7976493B2 (en) 2009-05-05 2011-07-12 Calibra Medical, Inc. Disposable infusion device with resettable last dose lock-out
WO2010135184A1 (en) 2009-05-18 2010-11-25 Telcordia Technologies, Inc. A mobile enabled social networking application to support closed, moderated group interactions for purpose of facilitating therapeutic care
KR101091056B1 (ko) 2009-05-22 2011-12-08 동서대학교산학협력단 약물 투여 모니터링 장치 및 그 방법
US8777897B2 (en) 2009-07-06 2014-07-15 Carefusion 303, Inc. Fluid delivery systems and methods having wireless communication
US8344847B2 (en) 2009-07-09 2013-01-01 Medtronic Minimed, Inc. Coordination of control commands in a medical device system having at least one therapy delivery device and at least one wireless controller device
US8547239B2 (en) 2009-08-18 2013-10-01 Cequr Sa Methods for detecting failure states in a medicine delivery device
US8932256B2 (en) 2009-09-02 2015-01-13 Medtronic Minimed, Inc. Insertion device systems and methods
US10071198B2 (en) 2012-11-02 2018-09-11 West Pharma. Servicees IL, Ltd. Adhesive structure for medical device
US20120219558A1 (en) 2009-09-25 2012-08-30 Yan Ni Antagonists of pcsk9
DK2301611T3 (da) 2009-09-25 2012-10-29 Carebay Europe Ltd Lægemiddelafgivelsesindretning
US9035744B2 (en) 2009-10-01 2015-05-19 Blackberry Limited Method and apparatus for monitoring and controlling a medical device using a wireless mobile communication device
US7967773B2 (en) 2009-10-13 2011-06-28 Smiths Medical Asd, Inc. Two piece medication cassette closure apparatus and method
CN104474605B (zh) 2009-10-13 2017-12-19 瓦莱里塔斯公司 流体输送装置
CN102596249A (zh) 2009-10-30 2012-07-18 默沙东公司 Ax1和ax189 pcsk9拮抗剂和变体
IN2012DN03824A (enExample) 2009-10-30 2015-08-28 Merck Sharp & Dohme
US8945066B2 (en) 2009-11-06 2015-02-03 Crisi Medical Systems, Inc. Medication injection site and data collection system
US8394053B2 (en) 2009-11-06 2013-03-12 Crisi Medical Systems, Inc. Medication injection site and data collection system
US8449504B2 (en) 2009-11-11 2013-05-28 Calibra Medical, Inc. Wearable infusion device and system
US20110119080A1 (en) 2009-11-19 2011-05-19 Abbott Diabetes Care Inc. Method and system for analyte data transmission and report generation
US8882701B2 (en) 2009-12-04 2014-11-11 Smiths Medical Asd, Inc. Advanced step therapy delivery for an ambulatory infusion pump and system
AR079336A1 (es) 2009-12-11 2012-01-18 Irm Llc Antagonistas de la pro-proteina convertasa-subtilisina/quexina tipo 9 (pcsk9)
US20110144587A1 (en) 2009-12-11 2011-06-16 Stone Robert T Liquid agent delivery apparatus, system and method
DK2512559T3 (en) 2009-12-16 2019-03-25 Becton Dickinson Co SELF-INJECTIVE DEVICE
WO2011075103A1 (en) 2009-12-16 2011-06-23 Becton, Dickinson And Company Self-injection device
WO2011075105A1 (en) 2009-12-16 2011-06-23 Becton, Dickinson And Company Self-injection device
JP5650242B2 (ja) 2009-12-16 2015-01-07 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 自己注射器具
US9555187B2 (en) 2009-12-16 2017-01-31 Becton, Dickinson And Company Self-injection device
US9421321B2 (en) 2009-12-30 2016-08-23 Medtronic Minimed, Inc. Connection and alignment systems and methods
US20110160696A1 (en) 2009-12-31 2011-06-30 Abbott Diabetes Care Inc. Injection port device adapted for use with insulin pump
US8070723B2 (en) 2009-12-31 2011-12-06 Medtronic Minimed, Inc. Activity guard
US8348898B2 (en) 2010-01-19 2013-01-08 Medimop Medical Projects Ltd. Automatic needle for drug pump
US10911515B2 (en) 2012-05-24 2021-02-02 Deka Products Limited Partnership System, method, and apparatus for electronic patient care
CA2728831A1 (en) 2010-01-22 2011-07-22 Lifescan, Inc. Diabetes management unit, method, and system
US9662438B2 (en) * 2010-02-05 2017-05-30 Deka Products Limited Partnership Devices, methods and systems for wireless control of medical devices
JP6150523B2 (ja) * 2010-02-05 2017-06-21 デカ・プロダクツ・リミテッド・パートナーシップ 注入ポンプ装置、方法およびシステム
JP5805111B2 (ja) 2010-02-18 2015-11-04 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング トーションばねを備えた自動注射器
RU2012140732A (ru) 2010-02-25 2014-03-27 Лайфскэн Скотлэнд Лимитед Метод определения концентрации анализируемого вещества и система для дозировки инсулина с функцией предупредительных сообщений
JP5932670B2 (ja) 2010-03-11 2016-06-08 ライナット ニューロサイエンス コーポレイション ｐＨ依存性の抗原結合を有する抗体
TW201200190A (en) 2010-03-26 2012-01-01 Sanofi Aventis Deutschland Electro-mechanical drug delivery device
US20130184640A1 (en) * 2010-04-20 2013-07-18 Minipumps, Llc Accurate flow control in drug pump devices
EP2560703A2 (en) 2010-04-20 2013-02-27 MiniPumps, LLC Electrolytically driven drug pump devices
JP5809242B2 (ja) 2010-04-21 2015-11-10 アッヴィ バイオテクノロジー リミテッド 治療薬の制御送達のための装着型自動注入装置
US8821454B2 (en) 2010-05-12 2014-09-02 Bioquiddity, Inc. Apparatus for dispensing medicinal fluids and method of making same
US9737659B2 (en) 2010-05-12 2017-08-22 Bioq Pharma Incorporated Apparatus for dispensing medicinal fluids and method of making same
SG186094A1 (en) * 2010-06-07 2013-01-30 Amgen Inc Drug delivery device
US11462321B2 (en) * 2010-08-12 2022-10-04 Fenwal, Inc. Mobile applications for blood centers
US9950112B2 (en) * 2010-08-17 2018-04-24 University Of Florida Research Foundation, Incorporated Intelligent drug and/or fluid delivery system to optimizing medical treatment or therapy using pharmacodynamic and/or pharamacokinetic data
WO2012032411A2 (en) 2010-09-07 2012-03-15 Tecpharma Licensing Ag Automatic injection device
US20120066140A1 (en) 2010-09-14 2012-03-15 Nokia Corporation Method and apparatus for monitoring adherence to prescribed regimens
US9498573B2 (en) * 2010-09-24 2016-11-22 Perqflo, Llc Infusion pumps
US9320849B2 (en) 2010-09-24 2016-04-26 Perqflo, Llc Infusion pumps
US9216249B2 (en) 2010-09-24 2015-12-22 Perqflo, Llc Infusion pumps
US8915879B2 (en) 2010-09-24 2014-12-23 Perqflo, Llc Infusion pumps
EP2438945A1 (en) 2010-10-08 2012-04-11 Sanofi-Aventis Deutschland GmbH Reusable engine for an auto-injector
US8707392B2 (en) * 2010-10-15 2014-04-22 Roche Diagnostics Operations, Inc. Systems and methods for disease management
WO2012054438A1 (en) 2010-10-22 2012-04-26 Schering Corporation Anti-pcsk9
US9211378B2 (en) 2010-10-22 2015-12-15 Cequr Sa Methods and systems for dosing a medicament
JP6080769B2 (ja) 2010-11-03 2017-02-15 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング インターロックを備えた薬用モジュール
EP2455120A1 (en) 2010-11-19 2012-05-23 Sanofi-Aventis Deutschland GmbH Medical device comprising mechanical-electrical transducing means
US8905972B2 (en) 2010-11-20 2014-12-09 Perqflo, Llc Infusion pumps
GB201020472D0 (en) * 2010-12-02 2011-01-19 Oval Medical Technologies Ltd A drive assembly for an autoinjector
GB201020475D0 (en) 2010-12-02 2011-01-19 Oval Medical Technologies Ltd Delivery mechanism for an autoinjector
CA2821367A1 (en) 2010-12-17 2012-06-21 Sanofi-Aventis Deutschland Gmbh Medicament administration
CN103261230A (zh) 2010-12-22 2013-08-21 霍夫曼-拉罗奇有限公司 抗pcsk9抗体及使用方法
CN103582463B (zh) * 2011-01-19 2018-02-13 弗拉克泰尔实验室公司 用于组织处理的装置与方法
SG192117A1 (en) 2011-01-28 2013-08-30 Sanofi Sa Human antibodies to pcsk9 for use in methods of treating particular groups of subjects
WO2012109530A1 (en) 2011-02-11 2012-08-16 Irm Llc Pcsk9 antagonists
US8639288B1 (en) 2011-02-22 2014-01-28 Medavie Technologies Injector device
WO2012122520A1 (en) * 2011-03-10 2012-09-13 Abbott Diabetes Care Inc. Multi-function analyte monitor device and methods of use
US9415167B2 (en) 2011-03-22 2016-08-16 Novartis Ag Infrared skin detection sensor
EP2689359B1 (en) 2011-03-24 2020-11-25 Sanofi-Aventis Deutschland GmbH Device and method for detecting an actuation action performable with a medical device
WO2012130901A1 (en) * 2011-03-30 2012-10-04 Sanofi-Aventis Deutschland Gmbh Injection device
EP2700424B1 (en) * 2011-04-19 2018-01-10 Terumo Kabushiki Kaisha Infusion pump
HUE042822T2 (hu) * 2011-04-20 2019-07-29 Amgen Inc Automata befecskendezõ szerkezet
ES2605817T3 (es) 2011-04-21 2017-03-16 Abbvie Inc. Dispositivo de inyección automático portátil
US9636461B2 (en) 2011-05-06 2017-05-02 Novo Nordisk A/S System for optimizing a drug dosage regimen over time
JOP20200043A1 (ar) 2011-05-10 2017-06-16 Amgen Inc طرق معالجة أو منع الاضطرابات المختصة بالكوليسترول
US9808577B2 (en) 2011-05-10 2017-11-07 Insuline Medical Ltd. Device, system and method for facilitating syringe based drug delivery and management thereof
JP6050331B2 (ja) * 2011-05-25 2016-12-21 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 投薬インターフェース・センサを有する薬剤送達デバイスおよびこのデバイスを制御する方法
EP2714152B1 (en) 2011-05-25 2017-12-20 Sanofi-Aventis Deutschland GmbH Medicament delivery device with cap
EP2535071B1 (de) 2011-06-16 2018-06-13 F. Hoffmann-La Roche AG Medikationsvorrichtung zur dosierten Abgabe eines fluiden Mediums
EP2537546A1 (en) 2011-06-21 2012-12-26 Sanofi-Aventis Deutschland GmbH Medicament delivery device with dose control mechanism
CN106267472B (zh) 2011-07-15 2019-08-30 赛诺菲-安万特德国有限公司 带机电式驱动机构的药物递送装置
EP2736565B1 (en) 2011-07-25 2017-07-05 Preciflex SA Fluid dispenser
WO2013024160A2 (en) 2011-08-18 2013-02-21 Novo Nordisk A/S Drug delivery device with means for handling data
BR112014004530A2 (pt) 2011-09-02 2017-03-28 Unitract Syringe Pty Ltd mecanismo de acionamento para bombas de administração de fármaco com indicação de estado integrada
US9707335B2 (en) 2011-09-02 2017-07-18 Unitract Syringe Pty Ltd Drive mechanism for drug delivery pumps with integrated status indication
DK2750735T3 (en) 2011-09-02 2018-01-02 Hoffmann La Roche DOSAGE UNIT FOR AN AMBULATORY INFUSION DEVICE
CA2845379C (en) 2011-09-02 2019-08-06 Unitract Syringe Pty Ltd Insertion mechanism for a drug delivery pump
WO2013029999A1 (en) 2011-09-02 2013-03-07 F. Hoffmann-La Roche Ag Dosing unit for an ambulatory infusion device
US8905944B2 (en) 2011-09-07 2014-12-09 Vlv Associates, Inc. Protective cover assembly for a needle assembly
AU2012306064B2 (en) 2011-09-09 2017-02-23 Merck Patent Gmbh An auto-injector for epinephrine injection
CN103957961B (zh) * 2011-10-07 2016-08-17 诺沃—诺迪斯克有限公司 用于基于三轴磁性传感器确定元件位置的系统
IL216158A0 (en) * 2011-11-06 2011-12-29 Medimop Medical Projects Ltd Electronic autoinjector apparatus and cassettes for use therewith
ES2904536T3 (es) 2011-11-07 2022-04-05 Lilly Co Eli Dispositivos de inyección con mejoras ergonómicas
DE102011119000A1 (de) 2011-11-21 2013-05-23 Liebherr-Verzahntechnik Gmbh Verzahnmaschine und Verfahren zur Herstellung oder Bearbeitung von Verzahnungen
JP2014533539A (ja) 2011-11-22 2014-12-15 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング その駆動のためのコントローラと時間ロックアウト機構とを備えたペン型薬物注射デバイス
US20140108031A1 (en) 2011-12-29 2014-04-17 Daniel Ferrara System and method for increasing medication adherence rates
US10052435B2 (en) 2012-01-31 2018-08-21 Precifiex SA Skin-attachable miniature drug injection device with remote activation capability and dry drug carrier within injection needle
EP2809375B1 (en) 2012-01-31 2021-08-11 Medimop Medical Projects Ltd. Time dependent drug delivery apparatus
EP2628494A1 (en) 2012-02-17 2013-08-21 Sensile Pat AG Liquid storage and delivery system
WO2013127428A1 (en) 2012-02-27 2013-09-06 F. Hoffmann-La Roche Ag Spring force assembly for biasing or actuating stoppers of syringes, injection pen cartridges and the like
US20130226608A1 (en) 2012-02-28 2013-08-29 Christopher Di Lascia System for identifying, monitoring, influencing and rewarding healthcare behavior
AU2013204609B2 (en) 2012-03-02 2015-10-01 Abbvie Inc. Automatic injection training device
EP2825500B1 (en) 2012-03-13 2016-01-06 Becton Dickinson France Method of manufacture for a miniaturized drug delivery device
US9072827B2 (en) 2012-03-26 2015-07-07 Medimop Medical Projects Ltd. Fail safe point protector for needle safety flap
US10283014B2 (en) * 2012-04-04 2019-05-07 Jbcb Holdings, Llc Smart packaging and display system
ES2781548T3 (es) 2012-04-13 2020-09-03 Becton Dickinson Co Dispositivo de infusión con característica de seguridad para prevenir cualquier activación involuntaria
US9335910B2 (en) 2012-04-23 2016-05-10 Tandem Diabetes Care, Inc. System and method for reduction of inadvertent activation of medical device during manipulation
EP2656865A1 (en) * 2012-04-24 2013-10-30 Sanofi-Aventis Deutschland GmbH Syringe carrier with needle shield and data storage device for use in a medical auto-injection device
US8817258B2 (en) 2012-05-21 2014-08-26 Common Sensing Inc. Dose measurement system and method
CN104507516B (zh) * 2012-05-24 2018-02-16 德卡产品有限公司 用于输注流体的装置
US9715327B2 (en) 2012-06-07 2017-07-25 Tandem Diabetes Care, Inc. Preventing inadvertent changes in ambulatory medical devices
EP2674179A1 (en) 2012-06-15 2013-12-18 Ares Trading S.A. Injection device
US8700133B2 (en) * 2012-06-18 2014-04-15 Smart Iv Llc Apparatus and method for monitoring catheter insertion
HK1209072A1 (en) 2012-07-05 2016-03-24 Unitract Syringe Pty Ltd Automatic injectors for injectable cartridges and drive control mechanisms therefor
EP2682141A1 (en) 2012-07-06 2014-01-08 Sanofi-Aventis Deutschland GmbH Injection system
US20140012511A1 (en) 2012-07-09 2014-01-09 Dexcom, Inc. Systems and methods for leveraging smartphone features in continuous glucose monitoring
ES2831602T3 (es) 2012-07-10 2021-06-09 Becton Dickinson France Sas Sistema de inyección integrado y dispositivo de comunicaciones
US8454557B1 (en) 2012-07-19 2013-06-04 Asante Solutions, Inc. Infusion pump system and method
EP2879741B1 (en) 2012-07-31 2021-04-28 Nipro Healthcare Systems, LLC Device and method for dispensing fluid from an infusion pump
US20140074062A1 (en) 2012-08-06 2014-03-13 Sean Caffey Piston pump devices
US9867929B2 (en) 2012-08-15 2018-01-16 Becton, Dickinson And Company Pump engine with metering system for dispensing liquid medication
EP2698180A1 (en) 2012-08-15 2014-02-19 Sanofi-Aventis Deutschland GmbH Autoinjector
JP6355169B2 (ja) * 2012-08-29 2018-07-11 ユーエヌエル ホールディングス エルエルシーＵＮＬ Ｈｏｌｄｉｎｇｓ ＬＬＣ 薬剤送達ポンプ用制御送達駆動機構
WO2014037331A1 (en) 2012-09-06 2014-03-13 Sanofi-Aventis Deutschland Gmbh Pen-type drug injection device and electronic add-on monitoring module for monitoring and logging dose setting and administration
WO2014047638A1 (en) * 2012-09-24 2014-03-27 Minipumps, Llc Drug-delivery pump with intelligent control
US9782538B2 (en) 2012-09-27 2017-10-10 Becton, Dickinson And Company Angled inserter for drug infusion
EP2716317A1 (en) 2012-10-04 2014-04-09 Sanofi-Aventis Deutschland GmbH Medicament delivery device with trigger button
US9789250B2 (en) 2012-10-05 2017-10-17 Becton, Dickinson And Company Infusion set with safety device
GB2506918A (en) 2012-10-12 2014-04-16 Cambridge Consultants Injector device
JP2014079325A (ja) * 2012-10-15 2014-05-08 Seiko Epson Corp 流体注入装置
EP2722065A1 (en) 2012-10-18 2014-04-23 Sanofi-Aventis Deutschland GmbH Auto-injector
JP6205701B2 (ja) 2012-10-22 2017-10-04 セイコーエプソン株式会社 流体注入装置
GB201218913D0 (en) 2012-10-22 2012-12-05 Ucb Pharma Sa Auto-injector and drive unit therefor
WO2014064691A2 (en) 2012-10-23 2014-05-01 Insuline Medical Ltd. Drug dispensing-tracking device, system and method
JP2014087449A (ja) 2012-10-30 2014-05-15 Seiko Epson Corp 液体輸送装置及びカテーテルの抜け判定方法
US20160067347A1 (en) 2012-12-20 2016-03-10 Amgen Inc. Apj receptor agonists and uses thereof
WO2014106096A1 (en) 2012-12-27 2014-07-03 Kaleo, Inc. Devices, systems and methods for locating and interacting with medicament delivery systems
DE202013000411U1 (de) 2013-01-16 2013-01-24 H & B Electronic Gmbh & Co. Kg Dauerinfusionsvorrichtung
CN104955502B (zh) 2013-01-25 2018-11-06 尤尼特拉克特注射器控股有限公司 用于输药泵的液体限制机构
CA2898585C (en) 2013-01-25 2020-10-13 Unitract Syringe Pty Ltd Integrated sliding seal fluid pathway connection and drug containers for drug delivery pumps
DK2764881T3 (da) 2013-02-06 2019-10-28 Medirio Sa System til medicinsk behandling
US9446186B2 (en) 2013-03-01 2016-09-20 Bigfoot Biomedical, Inc. Operating an infusion pump system
US20140274874A1 (en) 2013-03-14 2014-09-18 Amgen Inc. Variants of tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods
US20140276423A1 (en) 2013-03-14 2014-09-18 Tandem Diabetes Care, Inc. Infusion system and methods
EP2970407B1 (en) 2013-03-14 2023-11-15 Amgen Inc. Variants of tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods
WO2014152704A1 (en) 2013-03-15 2014-09-25 Becton, Dickinson And Company Smart adapter for infusion devices
US10229607B2 (en) 2013-04-30 2019-03-12 Elwha Llc Systems and methods for competency training and use authorization for dispensing an agent
US9889252B2 (en) 2013-06-14 2018-02-13 Medtronic, Inc. Infusion device assembly
US20150005703A1 (en) 2013-06-28 2015-01-01 Animas Corporation Drug infusion device with safety interlock
DK2865325T3 (en) 2013-10-23 2018-02-19 Hoffmann La Roche STANDING ON THE SKIN OF INFUSION PUMP OR CONTINUOUS BLOOD SUGAR MONITOR WITH OPTICAL INDICATION ORGANIZATION
US20150182688A1 (en) 2013-12-31 2015-07-02 Abbvie Inc. Devices and methods for delivering a beneficial agent to a user
US10773032B2 (en) 2014-03-14 2020-09-15 Shl Medical Ag Monitoring device
US10195342B2 (en) 2014-04-24 2019-02-05 Becton, Dickinson And Company Cannula deployment mechanism
CN111840696B (zh) 2014-06-03 2022-12-20 安姆根有限公司 可控制药物递送系统和使用方法
WO2021034784A1 (en) * 2019-08-16 2021-02-25 Poltorak Technologies, LLC Device and method for medical diagnostics

Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12569622B2 (en) 2014-06-03 2026-03-10 Amgen Inc. Systems and methods for remotely processing data collected by a drug delivery device
US10695492B2 (en) 2014-06-03 2020-06-30 Amgen Inc. Drug delivery system and method of use
US11992659B2 (en) 2014-06-03 2024-05-28 Amgen Inc. Controllable drug delivery system and method of use
US11738146B2 (en) 2014-06-03 2023-08-29 Amgen Inc. Drug delivery system and method of use
US10646652B2 (en) 2014-06-03 2020-05-12 Amgen Inc. Controllable drug delivery system and method of use
US11213624B2 (en) 2014-06-03 2022-01-04 Amgen Inc. Controllable drug delivery system and method of use
IL281369A (en) * 2014-06-03 2021-04-29 Amgen Inc Systems and methods for remotely processing data collected by a drug delivery device
US12533298B2 (en) 2015-03-10 2026-01-27 Regeneron Pharmaceuticals, Inc. Aseptic piercing system and method
US11406565B2 (en) 2015-03-10 2022-08-09 Regeneran Pharmaceuticals, Inc. Aseptic piercing system and method
US10182969B2 (en) 2015-03-10 2019-01-22 Regeneron Pharmaceuticals, Inc. Aseptic piercing system and method
US20180308571A1 (en) * 2015-10-09 2018-10-25 Duke University Medication administration and adherence systems and related methods
US20210398664A1 (en) * 2016-03-14 2021-12-23 Fenwal, Inc. Cell processing method
US11901068B2 (en) * 2016-03-14 2024-02-13 Fenwal, Inc. Cell processing methods with process parameter control
US12226613B2 (en) 2017-05-05 2025-02-18 Regeneron Pharmaceuticals, Inc. Auto-injector and related methods of use
US11547801B2 (en) 2017-05-05 2023-01-10 Regeneron Pharmaceuticals, Inc. Auto-injector
WO2019018169A1 (en) 2017-07-21 2019-01-24 Amgen Inc. PERMEABLE GAS SEALING ELEMENT FOR MEDICINE CONTAINER AND METHODS OF ASSEMBLY
EP4292576A2 (en) 2017-07-21 2023-12-20 Amgen Inc. Gas permeable sealing member for drug container and methods of assembly
WO2019022950A1 (en) 2017-07-25 2019-01-31 Amgen Inc. DRUG DELIVERY DEVICE WITH CONTAINER ACCESS SYSTEM AND ASSEMBLY METHOD THEREOF
EP4085942A1 (en) 2017-07-25 2022-11-09 Amgen Inc. Drug delivery device with gear module and related method of assembly
WO2019022951A1 (en) 2017-07-25 2019-01-31 Amgen Inc. DRUG DELIVERY DEVICE WITH GEAR MODULE AND ASSEMBLY METHOD THEREOF
WO2019036181A1 (en) 2017-08-18 2019-02-21 Amgen Inc. BODY INJECTOR WITH STERILE ADHESIVE PATCH
WO2019070552A1 (en) 2017-10-06 2019-04-11 Amgen Inc. DRUG DELIVERY DEVICE COMPRISING A LOCKOUT ASSEMBLY AND ASSOCIATED ASSEMBLY METHOD
EP4257164A2 (en) 2017-10-06 2023-10-11 Amgen Inc. Drug delivery device with interlock assembly and related method of assembly
WO2019074579A1 (en) 2017-10-09 2019-04-18 Amgen Inc. DRUG DELIVERY DEVICE COMPRISING A DRIVE ASSEMBLY AND ASSEMBLY METHOD THEREOF
WO2019090086A1 (en) 2017-11-03 2019-05-09 Amgen Inc. Systems and approaches for sterilizing a drug delivery device
WO2019090079A1 (en) 2017-11-03 2019-05-09 Amgen Inc. System and approaches for sterilizing a drug delivery device
WO2019090303A1 (en) 2017-11-06 2019-05-09 Amgen Inc. Fill-finish assemblies and related methods
USD1007676S1 (en) 2021-11-16 2023-12-12 Regeneron Pharmaceuticals, Inc. Wearable autoinjector
USD1122440S1 (en) 2021-11-16 2026-04-14 Regeneron Pharmaceuticals, Inc. Wearable autoinjector

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