US20130180966A1 - Laser cutting system and methods for creating self-retaining sutures - Google Patents

Laser cutting system and methods for creating self-retaining sutures Download PDF

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US20130180966A1
US20130180966A1 US13/695,112 US201113695112A US2013180966A1 US 20130180966 A1 US20130180966 A1 US 20130180966A1 US 201113695112 A US201113695112 A US 201113695112A US 2013180966 A1 US2013180966 A1 US 2013180966A1
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suture
suture thread
laser
tissue
thread
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Jeffrey M. Gross
William L. D'Agostino
Lev Drubetsky
Alexander Naimagon
Jacob D. Conner
Kevin R. Whitworth
Ryan T. Woolsey
Fred M. Dickey
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Cilag GmbH International
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
    • A61B17/06166—Sutures
    • B23K26/365—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0401—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
    • B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
    • B23K26/00—Working by laser beam, e.g. welding, cutting or boring
    • B23K26/02—Positioning or observing the workpiece, e.g. with respect to the point of impact; Aligning, aiming or focusing the laser beam
    • B23K26/03—Observing, e.g. monitoring, the workpiece
    • B23K26/032—Observing, e.g. monitoring, the workpiece using optical means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
    • B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
    • B23K26/00—Working by laser beam, e.g. welding, cutting or boring
    • B23K26/02—Positioning or observing the workpiece, e.g. with respect to the point of impact; Aligning, aiming or focusing the laser beam
    • B23K26/06—Shaping the laser beam, e.g. by masks or multi-focusing
    • B23K26/064—Shaping the laser beam, e.g. by masks or multi-focusing by means of optical elements, e.g. lenses, mirrors or prisms
    • B23K26/0652—Shaping the laser beam, e.g. by masks or multi-focusing by means of optical elements, e.g. lenses, mirrors or prisms comprising prisms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
    • B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
    • B23K26/00—Working by laser beam, e.g. welding, cutting or boring
    • B23K26/02—Positioning or observing the workpiece, e.g. with respect to the point of impact; Aligning, aiming or focusing the laser beam
    • B23K26/06—Shaping the laser beam, e.g. by masks or multi-focusing
    • B23K26/0665—Shaping the laser beam, e.g. by masks or multi-focusing by beam condensation on the workpiece, e.g. for focusing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
    • B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
    • B23K26/00—Working by laser beam, e.g. welding, cutting or boring
    • B23K26/08—Devices involving relative movement between laser beam and workpiece
    • B23K26/083—Devices involving movement of the workpiece in at least one axial direction
    • B23K26/1458—
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
    • B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
    • B23K26/00—Working by laser beam, e.g. welding, cutting or boring
    • B23K26/14—Working by laser beam, e.g. welding, cutting or boring using a fluid stream, e.g. a jet of gas, in conjunction with the laser beam; Nozzles therefor
    • B23K26/1462—Nozzles; Features related to nozzles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
    • B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
    • B23K26/00—Working by laser beam, e.g. welding, cutting or boring
    • B23K26/36—Removing material
    • B23K26/361—Removing material for deburring or mechanical trimming
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
    • B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
    • B23K26/00—Working by laser beam, e.g. welding, cutting or boring
    • B23K26/36—Removing material
    • B23K26/362—Laser etching
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
    • B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
    • B23K37/00—Auxiliary devices or processes, not specially adapted to a procedure covered by only one of the preceding main groups
    • B23K37/04—Auxiliary devices or processes, not specially adapted to a procedure covered by only one of the preceding main groups for holding or positioning work
    • A—HUMAN NECESSITIES
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    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/064—Surgical staples, i.e. penetrating the tissue
    • A61B17/0644—Surgical staples, i.e. penetrating the tissue penetrating the tissue, deformable to closed position
    • A—HUMAN NECESSITIES
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    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00526—Methods of manufacturing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0401—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
    • A61B2017/0417—T-fasteners
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0401—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
    • A61B2017/0427—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors having anchoring barbs or pins extending outwardly from the anchor body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
    • A61B17/06004—Means for attaching suture to needle
    • A61B2017/06038—Means for attaching suture to needle soldered, brazed or welded
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
    • A61B17/06166—Sutures
    • A61B2017/06176—Sutures with protrusions, e.g. barbs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3937—Visible markers

Definitions

  • the present invention relates generally to laser-cutting equipment and methods of manufacturing self-retaining suture systems for surgical procedures.
  • Wound closure devices such as sutures, staples and tacks have been widely used in superficial and deep surgical procedures in humans and animals for closing wounds, repairing traumatic injuries or defects, joining tissues together (bringing severed tissues into approximation, closing an anatomical space, affixing single or multiple tissue layers together, creating an anastomosis between two hollow/luminal structures, adjoining tissues, attaching or reattaching tissues to their proper anatomical location), attaching foreign elements to tissues (affixing medical implants, devices, prostheses and other functional or supportive devices), and for repositioning tissues to new anatomical locations (repairs, tissue elevations, tissue grafting and related procedures) to name but a few examples.
  • Sutures are often used as wound closure devices.
  • Sutures typically consist of a filamentous suture thread attached to a needle with a sharp point.
  • Suture threads can be made from a wide variety of materials including bioabsorbable (i.e., that break down completely in the body over time), or non-absorbable (permanent; non-degradable) materials.
  • Absorbable sutures have been found to be particularly useful in situations where suture removal might jeopardize the repair or where the natural healing process renders the support provided by the suture material unnecessary after wound healing has been completed; as in, for example, completing an uncomplicated skin closure.
  • Non-degradable (non-absorbable) sutures are used in wounds where healing may be expected to be protracted or where the suture material is needed to provide physical support to the wound for long periods of time; as in, for example, deep tissue repairs, high tension wounds, many orthopedic repairs and some types of surgical anastomosis.
  • a wide variety of surgical needles are available; the shape and size of the needle body and the configuration of the needle tip is typically selected based upon the needs of the particular application.
  • the suture needle is advanced through the desired tissue on one side of the wound and then through the adjacent side of the wound.
  • the suture is then formed into a “loop” which is completed by tying a knot in the suture to hold the wound closed.
  • Knot tying takes time and causes a range of complications, including, but not limited to (i) spitting (a condition where the suture, usually a knot) pushes through the skin after a subcutaneous closure), (ii) infection (bacteria are often able to attach and grow in the spaces created by a knot), (iii) bulk/mass (a significant amount of suture material left in a wound is the portion that comprises the knot), (iv) slippage (knots can slip or come untied), and (v) irritation (knots serve as a bulk “foreign body” in a wound).
  • Knot tying is also labor intensive and can comprise a significant percentage of the time spent closing a surgical wound. Additional operative procedure time is not only bad for the patient (complication rates rise with time spent under anesthesia), but it also adds to the overall cost of the operation (many surgical procedures are estimated to cost between $15 and $30 per minute of operating time).
  • Self-retaining sutures differ from conventional sutures in that self-retaining sutures possess numerous tissue retainers (such as barbs) which anchor the self-retaining suture into the tissue following deployment and resist movement of the suture in a direction opposite to that in which the retainers face, thereby eliminating the need to tie knots to affix adjacent tissues together (a “knotless” closure).
  • Knotless tissue-approximating devices having barbs have been previously described in, for example, U.S. Pat. No. 5,374,268, disclosing armed anchors having barb-like projections, while suture assemblies having barbed lateral members have been described in U.S. Pat. Nos. 5,584,859 and 6,264,675.
  • Self-retaining systems for wound closure also result in better approximation of the wound edges, evenly distribute the tension along the length of the wound (reducing areas of tension that can break or lead to ischemia), decrease the bulk of suture material remaining in the wound (by eliminating knots) and reduce spitting (the extrusion of suture material—typically knots—through the surface of the skin. All of these features are thought to reduce scarring, improve cosmesis, and increase wound strength relative to wound closures using plain sutures or staples.
  • self-retaining sutures because such sutures avoid knot tying, allow patients to experience an improved clinical outcome, and also save time and costs associated with extended surgeries and follow-up treatments. It is noted that all patents, patent applications and patent publications identified throughout are incorporated herein by reference in their entirety.
  • self-retaining sutures provide easier handling in anatomically tight or deep places (such as the pelvis, abdomen and thorax) and make it easier to approximate tissues in laparoscopic/endoscopic and minimally invasive procedures; all without having to secure the closure via a knot. Greater accuracy allows self-retaining sutures to be used for more complex closures (such as those with diameter mismatches, larger defects or purse string suturing) than can be accomplished with plain sutures.
  • a self-retaining suture may be unidirectional, having one or more retainers oriented in one direction along the length of the suture thread; or bidirectional, typically having one or more retainers oriented in one direction along a portion of the thread, followed by one or more retainers oriented in another (often opposite) direction over a different portion of the thread (as described with barbed retainers in U.S. Pat. Nos. 5,931,855 and 6,241,747).
  • one form of unidirectional self-retaining suture includes a tissue anchor on the distal end and a needle on the proximal end and a plurality of barbs on the surface of the suture thread having tips projecting “away” from the needle.
  • the tissue anchor is designed to secure the distal end of the suture and includes in some embodiments a loop, staple, tack, bar, plug, sheet, or ball.
  • one form of bidirectional self-retaining suture includes a needle at one end of a suture thread which has barbs having tips projecting “away” from the needle until the transition point (often the midpoint) of the suture is reached; at the transition point the configuration of barbs reverses itself about 180° (such that the barbs are now facing in the opposite direction) along the remaining length of the suture thread before attaching to a second needle at the opposite end (with the result that the barbs on this portion of the suture also have tips projecting “away” from the nearest needle).
  • the barbs on both “halves” of a typical bidirectional self-retaining suture have tips that point towards the middle, with a transition segment (lacking barbs) interspersed between them, and with a needle attached to either end.
  • the present invention provides laser cutting apparatus for creating retainers on a suture thread.
  • the present invention provides apparatus for stabilizing a suture during laser-cutting of retainers.
  • the present invention provides methods for cutting retainers on a suture thread with a laser.
  • FIG. 1A is a perspective view of a bidirectional self-retaining suture.
  • FIGS. 1B-1D are enlarged views of portions of the suture of FIG. 1A .
  • FIG. 1E is a perspective view of a unidirectional self-retaining suture.
  • FIGS. 1F-1H are views of alternative tissue anchors for the unidirectional self-retaining suture of FIG. 1E .
  • FIG. 2A shows a schematic diagram of a laser-machining system suitable for forming retainers on a suture thread according to an embodiment of the present invention.
  • FIG. 2B is an image of a Gaussian laser beam.
  • FIG. 2C is a graphical representation of the power density distribution in a Gaussian laser beam.
  • FIG. 2D is an image of a laser beam from an axicon prism system.
  • FIG. 2E is a graphical representation of the power density distribution in a laser beam from an axicon prism system.
  • FIG. 3A shows a sectional view of an air bearing for use in the laser-machining system of FIG. 2 according to an embodiment of the present invention.
  • FIG. 3B shows a partial perspective view of the air bearing of FIG. 3A .
  • FIG. 4A is a flow chart of a method for creating a self-retaining suture utilizing the laser-machining system of FIG. 2 according to an embodiment of the present invention.
  • FIGS. 4B-4D are perspective views of a suture filament during the process of generating a laser-cut retainer utilizing the laser-machining system of FIG. 2 according to an embodiment of the present invention.
  • FIG. 5 is an image of a laser-cut surface of a self-retaining suture.
  • FIG. 6 is a graph showing the profile of the laser-cut surface of FIG. 5 .
  • FIG. 7 shows a retainer distribution configurations for a self-retaining suture made utilizing the laser-machining system of FIG. 2 .
  • FIGS. 8A-8F show examples of self-retaining sutures made utilizing the laser-machining system of FIG. 2 .
  • Self-retaining system refers to a self-retaining suture together with devices for deploying the suture into tissue.
  • deployment devices include, without limitation, suture needles and other deployment devices as well as sufficiently rigid and sharp ends on the suture itself to penetrate tissue.
  • Self-retaining suture refers to a suture that comprises features on the suture filament for engaging tissue without the need for a knot or suture anchor.
  • tissue retainer refers to a physical feature of a suture filament which is adapted to mechanically engage tissue and resist movement of the suture in at least one axial directions.
  • tissue retainer or retainers can include hooks, projections, barbs, darts, extensions, bulges, anchors, protuberances, spurs, bumps, points, cogs, tissue engagers, traction devices, surface roughness, surface irregularities, surface defects, edges, facets and the like.
  • tissue retainers are adapted to engage tissue to resist movement of the suture in a direction other than the direction in which the suture is deployed into the tissue by the physician, by being oriented to substantially face the deployment direction.
  • the retainers lie flat when pulled in the deployment direction and open or “fan out” when pulled in a direction contrary to the deployment direction. As the tissue-penetrating end of each retainer faces away from the deployment direction when moving through tissue during deployment, the tissue retainers should not catch or grab tissue during this phase.
  • the tissue retainers may be configured to permit motion of the suture in one direction and resist movement of the suture in another direction without fanning out or deploying.
  • the tissue retainer may be configured or combined with other tissue retainers to resist motion of the suture filament in both directions.
  • a suture having such retainers is deployed through a device such as a cannula which prevents contact between the retainers and the tissue until the suture is in the desired location.
  • Retainer configurations refers to configurations of tissue retainers and can include features such as size, shape, flexibility, surface characteristics, and so forth. These are sometimes also referred to as “barb configurations”.
  • Bidirectional suture refers to a self-retaining suture having retainers oriented in one direction at one end and retainers oriented in the other direction at the other end.
  • a bidirectional suture is typically armed with a needle at each end of the suture thread.
  • Many bidirectional sutures have a transition segment located between the two barb orientations.
  • Transition segment refers to a retainer-free (barb-free) portion of a bidirectional suture located between a first set of retainers (barbs) oriented in one direction and a second set of retainers (barbs) oriented in another direction.
  • the transition segment can be at about the midpoint of the self-retaining suture, or closer to one end of the self-retaining suture to form an asymmetrical self-retaining suture system.
  • Suture thread refers to the filamentary body component of the suture.
  • the suture thread may be a monofilament, or comprise multiple filaments as in a braided suture.
  • the suture thread may be made of any suitable biocompatible material, and may be further treated with any suitable biocompatible material, whether to enhance the sutures' strength, resilience, longevity, or other qualities, or to equip the sutures to fulfill additional functions besides joining tissues together, repositioning tissues, or attaching foreign elements to tissues.
  • “Monofilament suture” refers to a suture comprising a monofilamentary suture thread.
  • Braided suture refers to a suture comprising a multifilamentary suture thread.
  • the filaments in such suture threads are typically braided, twisted, or woven together.
  • “Degradable suture” (also referred to as “biodegradable suture” or “absorbable suture”) refers to a suture which, after introduction into a tissue is broken down and absorbed by the body. Typically, the degradation process is at least partially mediated by, or performed in, a biological system. “Degradation” refers to a chain scission process by which a polymer chain is cleaved into oligomers and monomers. Chain scission may occur through various mechanisms, including, for example, by chemical reaction (e.g., hydrolysis, oxidation/reduction, enzymatic mechanisms or a combination of these) or by a thermal or photolytic process.
  • chemical reaction e.g., hydrolysis, oxidation/reduction, enzymatic mechanisms or a combination of these
  • Degradable suture material may include polymers such as polyglycolic acid, copolymers of glycolide and lactide, copolymers of trimethylene carbonate and glycolide with diethylene glycol (e.g., MAXONTM, Covidien), terpolymer composed of glycolide, trimethylene carbonate, and dioxanone (e.g., BIOSYNTM [glycolide (60%), trimethylene carbonate (26%), and dioxanone (14%)], Covidien), copolymers of glycolide, caprolactone, trimethylene carbonate, and lactide (e.g., CAPROSYNTM Covidien).
  • polymers such as polyglycolic acid, copolymers of glycolide and lactide, copolymers of trimethylene carbonate and glycolide with diethylene glycol (e.g., MAXONTM, Covidien), terpolymer composed of glycolide, trimethylene carbonate, and dioxanone (e.
  • a dissolvable suture can also include partially deacetylated polyvinyl alcohol.
  • Polymers suitable for use in degradable sutures can be linear polymers, branched polymers or multi-axial polymers. Examples of multi-axial polymers used in sutures are described in U.S. Patent Application Publication Nos. 2002/0161168, 2004/0024169, and 2004/0116620.
  • Sutures made from degradable suture material lose tensile strength as the material degrades.
  • Degradable sutures can be in either a braided multifilament form or a monofilament form.
  • Non-degradable suture refers to a suture comprising material that is not degraded by chain scission such as chemical reaction processes (e.g., hydrolysis, oxidation/reduction, enzymatic mechanisms or a combination of these) or by a thermal or photolytic process.
  • chain scission such as chemical reaction processes (e.g., hydrolysis, oxidation/reduction, enzymatic mechanisms or a combination of these) or by a thermal or photolytic process.
  • Non-degradable suture material includes polyamide (also known as nylon, such as nylon 6 and nylon 6,6), polyester (e.g., polyethylene terephthlate), polytetrafluoroethylene (e.g., expanded polytetrafluoroethylene), polyether-ester such as polybutester (block copolymer of butylene terephthalate and polytetra methylene ether glycol), polyurethane, metal alloys, metal (e.g., stainless steel wire), polypropylene, polyethelene, silk, and cotton.
  • Sutures made of non-degradable suture material are suitable for applications in which the suture is meant to remain permanently or is meant to be physically removed from the body.
  • Suture diameter refers to the diameter of the body of the suture. It is to be understood that a variety of suture lengths may be used with the sutures described herein and that while the term “diameter” is often associated with a circular periphery, it is to be understood herein to indicate a cross-sectional dimension associated with a periphery of any shape. Suture sizing is based upon diameter. United States Pharmacopeia (“USP”) designation of suture size runs from 0 to 7 in the larger range and 1-0 to 11-0 in the smaller range; in the smaller range, the higher the value preceding the hyphenated zero, the smaller the suture diameter.
  • USP United States Pharmacopeia
  • the actual diameter of a suture will depend on the suture material, so that, by way of example, a suture of size 5-0 and made of collagen will have a diameter of 0.15 mm, while sutures having the same USP size designation but made of a synthetic absorbable material or a non-absorbable material will each have a diameter of 0.1 mm.
  • the selection of suture size for a particular purpose depends upon factors such as the nature of the tissue to be sutured and the importance of cosmetic concerns; while smaller sutures may be more easily manipulated through tight surgical sites and are associated with less scarring, the tensile strength of a suture manufactured from a given material tends to decrease with decreasing size.
  • sutures and methods of manufacturing sutures disclosed herein are suited to a variety of diameters, including without limitation 7, 6, 5, 4, 3, 2, 1, 0, 1-0, 2-0, 3-0, 4-0, 5-0, 6-0, 7-0, 8-0, 9-0, 10-0 and 11-0.
  • Needle attachment refers to the attachment of a needle to a suture requiring same for deployment into tissue, and can include methods such as crimping, swaging, using adhesives, and so forth.
  • the suture thread is attached to the suture needle using methods such as crimping, swaging and adhesives. Attachment of sutures and surgical needles is described in U.S. Pat. Nos. 3,981,307, 5,084,063, 5,102,418, 5,123,911, 5,500,991, 5,722,991, 6,012,216, and 6,163,948, and U.S. Patent Application Publication No. US 2004/0088003).
  • the point of attachment of the suture to the needle is known as the swage.
  • “Suture needle” refers to needles used to deploy sutures into tissue, which come in many different shapes, forms and compositions. There are two main types of needles, traumatic needles and atraumatic needles. Traumatic needles have channels or drilled ends (that is, holes or eyes) and are supplied separate from the suture thread and are threaded on site. Atraumatic needles are eyeless and are attached to the suture at the factory by swaging or other methods whereby the suture material is inserted into a channel at the blunt end of the needle which is then deformed to a final shape to hold the suture and needle together. As such, atraumatic needles do not require extra time on site for threading and the suture end at the needle attachment site is generally smaller than the needle body.
  • the thread comes out of the needle's hole on both sides and often the suture rips the tissues to a certain extent as it passes through.
  • Most modern sutures are swaged atraumatic needles.
  • Atraumatic needles may be permanently swaged to the suture or may be designed to come off the suture with a sharp straight tug. These “pop-offs” are commonly used for interrupted sutures, where each suture is only passed once and then tied. For barbed sutures that are uninterrupted, these atraumatic needles are preferred.
  • Suture needles may also be classified according to the geometry of the tip or point of the needle.
  • needles may be (i) “tapered” whereby the needle body is round and tapers smoothly to a point; (ii) “cutting” whereby the needle body is triangular and has a sharpened cutting edge on the inside; (iii) “reverse cutting” whereby the cutting edge is on the outside; (iv) “trocar point” or “taper cut” whereby the needle body is round and tapered, but ends in a small triangular cutting point; (v) “blunt” points for sewing friable tissues; (vi) “side cutting” or “spatula points” whereby the needle is flat on top and bottom with a cutting edge along the front to one side (these are typically used for eye surgery).
  • Suture needles may also be of several shapes including, (i) straight, (ii) half curved or ski, (iii) 1 ⁇ 4 circle, (iv) 3 ⁇ 8 circle, (v) 1 ⁇ 2 circle, (vi) 5 ⁇ 8 circle, (v) and compound curve.
  • Suturing needles are described, for example, in U.S. Pat. Nos. 6,322,581 and 6,214,030; and 5,464,422; and 5,941,899; 5,425,746; 5,306,288 and 5,156,615; and 5,312,422; and 7,063,716.
  • Other suturing needles are described, for example, in U.S. Pat. Nos. 6,129,741; 5,897,572; 5,676,675; and 5,693,072.
  • the sutures described herein may be deployed with a variety of needle types (including without limitation curved, straight, long, short, micro, and so forth), needle cutting surfaces (including without limitation, cutting, tapered, and so forth), and needle attachment techniques (including without limitation, drilled end, crimped, and so forth). Moreover, the sutures described herein may themselves include sufficiently rigid and sharp ends so as to dispense with the requirement for deployment needles altogether.
  • Needle diameter refers to the diameter of a suture deployment needle at the widest point of that needle. While the term “diameter” is often associated with a circular periphery, it is to be understood herein to indicate a cross-sectional dimension associated with a periphery of any shape.
  • “Armed suture” refers to a suture having a suture needle on at least one suture deployment end.
  • Suture deployment end refers to an end of the suture to be deployed into tissue; one or both ends of the suture may be suture deployment ends.
  • the suture deployment end may be attached to a deployment device such as a suture needle, or may be sufficiently sharp and rigid to penetrate tissue on its own.
  • wound closure refers to a surgical procedure for closing of a wound.
  • An injury especially one in which the skin or another external or internal surface is cut, torn, pierced, or otherwise broken is known as a wound.
  • a wound commonly occurs when the integrity of any tissue is compromised (e.g., skin breaks or burns, muscle tears, or bone fractures).
  • a wound may be caused by an act, such as a puncture, fall, or surgical procedure; by an infectious disease; or by an underlying medical condition.
  • Surgical wound closure facilitates the biological event of healing by joining, or closely approximating, the edges of those wounds where the tissue has been torn, cut, or otherwise separated.
  • Surgical wound closure directly apposes or approximates the tissue layers, which serves to minimize the volume new tissue formation required to bridge the gap between the two edges of the wound. Closure can serve both functional and aesthetic purposes. These purposes include elimination of dead space by approximating the subcutaneous tissues, minimization of scar formation by careful epidermal alignment, and avoidance of a depressed scar by precise eversion of skin edges.
  • tissue elevation procedure refers to a surgical procedure for repositioning tissue from a lower elevation to a higher elevation (i.e. moving the tissue in a direction opposite to the direction of gravity).
  • the retaining ligaments of the face support facial soft tissue in the normal anatomic position.
  • Face-lift procedures are designed to lift these sagging tissues, and are one example of a more general class of medical procedure known as a tissue elevation procedure.
  • tissue elevation procedure reverses the appearance change that results from effects of aging and gravity over time, and other temporal effects that cause tissue to sag, such as genetic effects. It should be noted that tissue can also be repositioned without elevation; in some procedures tissues are repositioned laterally (away from the midline), medially (towards the midline) or inferiorly (lowered) in order to restore symmetry (i.e. repositioned such that the left and right sides of the body “match”).
  • Medical device refers to any object placed in the body for the purpose of restoring physiological function, reducing/alleviating symptoms associated with disease, and/or repairing and/or replacing damaged or diseased organs and tissues. While normally composed of biologically compatible synthetic materials (e.g., medical-grade stainless steel, titanium and other metals or polymers such as polyurethane, silicon, PLA, PLGA and other materials) that are exogenous, some medical devices and implants include materials derived from animals (e.g., “xenografts” such as whole animal organs; animal tissues such as heart valves; naturally occurring or chemically-modified molecules such as collagen, hyaluronic acid, proteins, carbohydrates and others), human donors (e.g., “allografts” such as whole organs; tissues such as bone grafts, skin grafts and others), or from the patients themselves (e.g., “autografts” such as saphenous vein grafts, skin grafts, tendon/ligament/mus
  • Medical devices that can be used in procedures in conjunction with the present invention include, but are not restricted to, orthopedic implants (artificial joints, ligaments and tendons; screws, plates, and other implantable hardware), dental implants, intravascular implants (arterial and venous vascular bypass grafts, hemodialysis access grafts; both autologous and synthetic), skin grafts (autologous, synthetic), tubes, drains, implantable tissue bulking agents, pumps, shunts, sealants, surgical meshes (e.g., hernia repair meshes, tissue scaffolds), fistula treatments, spinal implants (e.g., artificial intervertebral discs, spinal fusion devices, etc.) and the like.
  • orthopedic implants artificial joints, ligaments and tendons; screws, plates, and other implantable hardware
  • dental implants include, but are not restricted to, dental implants, intravascular implants (arterial and venous vascular bypass grafts, hemodialysis access grafts; both autologous and synthetic), skin graft
  • FIG. 1A illustrates a laser-cut self-retaining suture system 100 .
  • Self-retaining suture system 100 comprises needles 110 , 112 attached to self-retaining suture thread 102 .
  • Self-retaining suture thread 102 includes a plurality of retainers 130 distributed on the surface of a filament 120 .
  • In lead-in section 140 of filament 120 there are no retainers 130 .
  • In section 142 of filament 120 there are a plurality of retainers 130 arranged such that the suture can be deployed in the direction of needle 110 , but resists movement in the direction of needle 112 .
  • transition section 144 there are no retainers 130 .
  • section 146 there is a plurality of retainers 130 arranged such that the suture can be deployed in the direction of needle 112 , but resists movement in the direction of needle 110 .
  • lead-in section 148 of filament 120 there are no retainers 130 .
  • a break is shown in each of sections 140 , 142 , 144 , 146 and 148 to indicate that the length of each section may be varied and selected depending upon the application for which the suture is intended to be used.
  • transition section 144 can be asymmetrically located closer to needle 110 or needle 112 , if desired.
  • Self-retaining suture system 100 is composed of two arms. Each arm may be considered to be a section of self-retaining suture system 100 .
  • the first arm includes sections 142 and section 140 of self-retaining suture thread 102 and a curved needle 110 has relatively small retainer suitable for engaging harder/denser tissue.
  • the second arm includes sections 146 and 148 and needle 112 of self-retaining suture thread 102 .
  • a self-retaining suture system has single-armed sutures; dual-armed sutures; triple-armed sutures; multiple-armed sutures; heterofunctional sutures having two or more sections of suture having different features; dual-arm sutures having different types (or sizes) of needles on each end; single or dual-armed sutures for use with different layers/depth and types of tissue; single or dual armed sutures with sections of filament having different diameters for use with different layers/depth and types of tissue.
  • Retainers 130 are laser-cut retainers formed on the surface of filament 120 by cutting and/or ablating portions of the filament with a laser as described below.
  • the retainers 130 are in some embodiments identical to one another. In alternative embodiments, retainers 130 , vary in shape, dimensions and/ or distribution in different sections and/or within sections of the self-retaining suture thread 102 as best suited for engaging tissue. It is an advantage of self-retaining suture system having laser-cut retainers that it is feasible to create multiple configurations of retainers on a suture thread with a single cutting device as will be described below.
  • FIG. 1B illustrates a magnified view of self-retaining suture thread 102 in section 142 .
  • a plurality of retainers 130 is distributed on the surface of filament 120 .
  • the affixation of self-retaining sutures after deployment in tissue entails the penetration of retainer ends 132 into the surrounding tissue resulting in tissue being caught between the retainer 130 and the body of suture filament 120 .
  • the inner surface 134 of the retainer 130 that is in contact with the tissue that is caught between the retainer 130 and the body of filament 120 is referred to herein as the “tissue engagement surface” or “inner retainer surface.”
  • each retainer 130 has a tip 132 and tissue retainer surface 134 .
  • FIG. 1C illustrates a magnified view of self-retaining suture thread 102 in section 144 .
  • Section 144 may be referred to as the transition section of self-retaining suture system 100 .
  • Section 144 may be deployed in either both of the directions shown by arrows 136 and 138 .
  • the filament 120 in section 144 is, in some embodiments, provided with an identifiable feature.
  • section 144 of self-retaining suture system 100 is provided with an identifiable marker in the form of visible band 150 .
  • Band 150 represents a portion of filament 120 having a different visible characteristic than other portions of filament 120 which can thus be identified by a surgeon in order to identify and locate the transition section 144 of self-retaining suture system 100 .
  • markers are provided on other sections of the filament and/or needles in order to identify features of the self-retaining suture system associated with the section marked. Additionally, marker differences can include different shapes, different colors, different numbers, and different letters to name a few types of markers.
  • FIG. 1D illustrates a magnified view of self-retaining suture thread 102 in section 146 .
  • a plurality of retainers 130 is distributed on the surface of filament 120 .
  • each retainer 130 has a tip 132 and tissue retainer surface 134 .
  • tip 132 or retainer 130 engages tissue surrounding filament 120 and causes retainer 130 to fan out from filament 120 and engage the tissue with face 134 , thereby preventing movement of the suture in that direction.
  • retainers 130 are oriented in the opposite direction to the retainers 130 in section 142 .
  • FIG. 1E illustrates an alternative embodiment of a self-retaining suture system 160 .
  • Self-retaining suture system 160 includes needle 110 and sections 140 , 142 and 144 of self-retaining suture system 100 of FIG. 1A .
  • self-retaining suture system 160 is a single-armed system.
  • filament 120 terminates following section 146 in a tissue anchor 114 e.
  • Tissue anchor 114 e is a device for engaging tissue and preventing filament 120 from moving through tissue in the direction of needle 110 .
  • Tissue anchor 114 e is in some embodiments formed in one piece with filament 120 or formed separately and subsequently attached to filament 120 . As shown in FIG.
  • tissue anchor 114 e has a bar-shaped body 170 e which extends approximately perpendicular to the axis of filament 120 .
  • Bar-shaped body 170 e is sufficiently long and stiff to preclude movement of filament 120 in the direction of needle 110 after tissue anchor 114 e has engaged a tissue.
  • FIG. 1F shows an alternative anchor 114 f which could be used in place of tissue anchor 114 e of FIG. 1E .
  • tissue anchor 114 f comprises a conical body 170 f.
  • Conical body 170 f has a pointed end 172 f and tissue engaging features 174 f which consist of ribs and/or barbs.
  • Tissue anchor 114 f is configured to be pushed into tissue in order to anchor filament 120 to that tissue and preclude movement of filament 120 in the direction of needle 110 .
  • FIG. 1G shows an alternative anchor 114 g which could be used in place of tissue anchor 114 e of FIG. 1E .
  • tissue anchor 114 g comprises a loop 170 g.
  • Loop 170 g is, in this embodiment, formed by folding back the end 172 g of filament 120 and securing end 172 g to filament 120 by welding, fusing and/or adhesive. Loop 170 g is thus formed from the material of filament 120 .
  • Loop 170 g has an aperture 174 g through which needle 110 can pass in order to create a noose which can be used to engage tissue and preclude movement of filament 120 in the direction of needle 110 .
  • FIG. 1H shows an alternative anchor 114 h which could be used in place of tissue anchor 114 e of FIG. 1E .
  • tissue anchor 114 h comprises a staple-shaped body 170 h.
  • Filament 120 passes through an aperture in anchor 114 h and is secured by a crimp 174 h.
  • Staple-shaped body 170 h has two points pointed end 172 h which can be deformed towards each other to engage tissue and preclude movement of filament 120 in the direction of needle 110 .
  • a laser machining system is provided and utilized to create retainers on the surface of a suture thread and/or provide visible markings on the suture thread.
  • the laser machining system uses a focused beam of coherent light to selectively cut and/or ablate material from a suture thread to generate retainers having a desired configuration on the suture thread.
  • the cutting/ablating process is a noncontact process.
  • a suitable laser machining system has very high spatial confinement and control and very low heat deposition to the suture thread so as to prevent damage to the suture thread during retainer formation.
  • a laser machining system is used to apply a laser beam to a volume of material within a suture thread.
  • the laser energy is absorbed by the material which is thereby vaporized and removed.
  • the suture thread is, in some embodiments, provided with a component which promotes absorption of the laser energy.
  • the laser light is provided at power, wavelength, and pulse duration selected to vaporize the selected volume of suture material without damaging the remaining suture thread.
  • the wavelength of the laser is typically in the range of UV to visible to infrared light. Light as used herein is not limited to the visible spectrum. The ideal wavelength or spectrum of wavelengths is selected to achieve the best cutting/ablation characteristics.
  • the exposure required to cause the ablation/cutting may be accomplished in one continuous exposure or a plurality of pulses. Exposure to a plurality of laser pulses allows the energy of each laser pulse to dissipate and therefore induces a lower temperature rise in the suture thread than one continuous pulse of the same total length.
  • the power of the laser beam and/or pulse duration are controlled to cut/ablate the desired material while delivering insufficient total energy to the surrounding material to adversely affect the bulk material properties of the suture thread.
  • a femtosecond laser is used which provides high power for very short duration laser pulses.
  • the wavelength, power, focus and/or pulse duration are also controlled to achieve the desired penetration of the laser into the suture thread.
  • a variety of different lasers and control system can be used to direct the laser to the selected locations of a suture to create the retainers.
  • a steered beam system is used to achieve the desired cutting/ablation.
  • a pulsed laser is directed at a moving point on the suture thread.
  • Mirrors mounted on computer-controlled galvanometers are used to direct the laser beam at targeted volumes of the suture thread.
  • a mask or other optics are used to generate a shaped laser beam having a suitable shape for achieving the desired cutting/ablation.
  • a stepwise pattern is used to create the laser marked indicia.
  • a volume of the suture material is targeted and ablated/cut by modulating a laser on and off
  • the suture and/or laser is then moved to align a new target volume with the laser and the new target is ablated/cut by modulating the laser on and off.
  • the process is continued to direct the beam stepwise or to move the suture thread stepwise until the desired retainer configuration is achieved.
  • FIG. 2A is a schematic diagram of a laser-machining system suitable for manufacturing self-retaining sutures.
  • a laser-machining system 200 includes five subsystems.
  • the five subsystems of laser-machining system 200 are laser subsystem 210 , optics subsystem 220 , imaging subsystem 230 , transport subsystem 240 and control subsystem 250 .
  • Laser subsystem 210 supplies laser power to laser machining system 200 in the form of laser beam 202 .
  • Laser subsystem 210 is under control of control subsystem 250 .
  • Laser subsystem 210 includes laser 212 , laser attenuator 214 and laser homogenizer 216 .
  • Laser 212 generates laser beam 202 .
  • Laser attenuator 214 modulates laser beam 202 , allowing it to pass and blocking it as necessary under control of control subsystem 250 .
  • Laser homogenizer 216 modifies the laser beam 202 to produce an even power density across laser beam 202 .
  • laser subsystem 210 is a femtosecond laser system.
  • a femtosecond laser system provides ultra short pulses of laser energy suitable for cutting/ablating material from a suture thread with a high degree of accuracy and without causing damage to the surrounding suture thread.
  • the laser energy is deposited into small volumes of material by optical absorption followed by avalanche ionization of the material.
  • the laser energy is deposited at a time scale much shorter than the timescale for heat transport in the material.
  • the material targeted by the laser beam is transformed from solid to vapor phase and to plasma formation almost instantaneously and without significant heat transfer to the surrounding material.
  • the femtosecond laser pulses thus reduce thermal damage to the suture thread.
  • a femtosecond laser is advantageous because it can achieve: high resolution and repeatability in a fully automated system; high aspect ratios for cutting/ablation of suture thread with low redeposition of ablated material; very localized effects and little damage to suture thread adjacent cutting/ablation zone; and effective cutting of suture thread material over a wide range of materials and diameters (including, for example USP 12-0 to 7).
  • a femtosecond laser system can cut/ablate suture material with submicron resolution and nanometer scale surface roughness of cut surfaces.
  • the parameters of the femtosecond laser can be adjusted to achieve the desired resolution, aspect ratio and reduce collateral damage including by selecting: the appropriate wavelength or combination of wavelengths; the power distribution of the beam (Gaussian, Top hat, axiconic to provide an annular ring profile); the beam energy and pulse duration; and the focal length and depth of focus for the optics system.
  • the parameters are in some cases modified for different suture thread materials and diameters and retainer configurations.
  • Laser beam 202 passes from laser subsystem 210 to optics subsystem 220 .
  • Optics subsystem 220 includes one or more mirrors 222 and lenses for directing and/or focusing laser beam 202 at a desired target.
  • optics subsystem 220 includes an object lens 224 from which laser beam 202 leaves optic subsystem 220 towards the desired target.
  • Optics subsystem 220 also includes one or more actuators 226 , 228 under control of computer subsystem 250 for adjusting the positions of the mirror(s) 222 and lens(es) 224 .
  • Imaging subsystem 230 allows observation of suture thread 204 and monitoring of the results of laser machining upon it.
  • Imaging subsystem 230 includes an imaging device 232 which is in some embodiments a camera.
  • Imaging system also includes an illumination device 234 for illuminating suture thread 120 .
  • Imaging subsystem 230 can also include one or more mirrors and lenses for directing light to and from suture thread 202 .
  • Imaging subsystem 230 provides images of suture thread 204 to control subsystem 250 .
  • imaging subsystem 230 is provided in-line with optics subsystem 220 as shown. That is to say that illumination device 234 delivers illumination to suture thread 204 and imaging device 232 receives an image of suture thread 204 through the optic subsystem 220 .
  • the images of suture thread 204 can be used by control subsystem 250 to verify the correct operation of the laser subsystem 210 and optics subsystem 220 and make configuration adjustments as necessary.
  • Advantageously image data from the imaging subsystem 230 can be used by the control subsystem 250 to monitor and adjust the depth of focus of the optic system to allow proper focusing and targeting of the laser beam.
  • an off-line imaging system can be used.
  • the images of the suture thread 204 can also be used for quality control of retainer formation including, in some embodiments, validating the correct creation of 100% of the retainers.
  • Transport subsystem 240 operates to support suture thread 204 and move suture thread 204 relative to laser beam 202 .
  • the laser subsystem 210 , imaging subsystem 230 , optics subsystem 220 and transport subsystem 240 are all securely mounted to a bench 206 to prevent relative movement/vibration of the systems except as controlled by transport subsystem 240 .
  • Transport subsystem 240 includes chucks 242 for holding each end of suture thread 204 . Chucks 242 are preferably driven by an actuator 243 which drives rotation of suture thread 204 around the longitudinal axis of the suture thread 204 .
  • Chucks 242 are mounted to an XY positioning stages 244 , 246 .
  • XY positioning stages 244 , 246 are preferably driven by actuators 245 , 247 which control the position of the suture thread 204 relative to the laser beam 202 .
  • XY positioning stages 244 , 246 are preferably aligned with the longitudinal axis of suture thread 204 such that one stage controls movement of the suture thread along its longitudinal axis relative to laser beam 202 and the other stage controls movement of suture thread 204 perpendicular to the longitudinal axis (across the laser beam 204 ).
  • Actuators 243 , 245 , 247 are preferably under the control of control subsystem 250 .
  • Transport subsystem 240 in some embodiments, includes a suture spool and mechanism (not shown) for automatically feeding lengths of suture thread to be held between chucks 242 without the need for rethreading the suture thread.
  • Transport subsystem 240 also includes a stabilization device 248 for stabilizing suture thread 204 adjacent the laser beam 202 .
  • Stabilization device 248 reduces movement of suture thread 204 adjacent the cutting region in order to enhance the accuracy of the laser machining operation.
  • stabilization device 248 is an air bearing which provides a stream of air to stabilize suture thread 204 without mechanically contacting suture thread 204 . The stream of air also serves to cool the suture thread 204 and eliminate smoke and particles from the cutting region.
  • Control subsystem 250 is a general purpose machine control system having outputs for controlling actuators and inputs for receiving data from machine sensors.
  • Control subsystem 250 includes memory for program and data storage.
  • the program and data storage includes parameters for operation of the laser subsystem 210 , optics subsystem 220 , imaging subsystem 230 , and transport subsystem 240 and/or recorded diagnostic and performance data concerning the operation of laser machining system 200 .
  • Data may be stored in control subsystem 250 or other data storage associated with the local network or WAN. Data may be stored in a single format or in multiple formats. Data may be stored on a single type of media or on multiple types of media e.g. hard disks, RAM, flash memory, floppy disks, web-storage systems, etc.
  • Control subsystem 250 includes one or more processors 252 which can be a computer processer, CPU, and typically includes a microcontroller, CPU, microprocessor or equivalent control circuitry or processor, designed specifically for controlling the laser machining system 200 , and may further include RAM or ROM memory, logic and timing circuitry, state machine circuitry, and I/O circuitry.
  • the control system contains and/or has access to programs and/or data which define the distribution of retainers to be formed on a filament and the shape/shapes of the retainers to be formed on the filament as well as the tolerances for the expected shape/shapes of the retainers.
  • the details of the design of control subsystem 250 are not critical to the present invention. Rather, any suitable control subsystem 250 may be used that carries out the functions described herein.
  • the use of computer/microprocessor-based control systems for controlling machine tools is well known in the art.
  • the laser beam provided by laser subsystem 210 and optic subsystem 220 has a Gaussian power density distribution.
  • FIG. 2B shows a representative image of a Gaussian laser beam 260 incident on a planar surface 268 .
  • the power density of Gaussian beam 260 drops off rapidly moving away from a peak at the center 262 of the beam 260 .
  • the diameter D of the zone of peak power density can be altered using the optic subsystem to focus the laser beam.
  • FIG. 2C shows a graphical representation of the power density distribution of Gaussian laser beam (such as laser beam 260 of FIG. 2B ).
  • An alternative laser beam shape/power distribution can be achieved by the use of an axicon prism system utilizing two axicon (rotationally revolved prism) and a lens.
  • the first axicon produces a ring
  • the lens focuses the ring to a thin (5 micron) width
  • the second axicon collimates the ring. Varying the distance between the axicon prisms provides the ability to control the diameter of the ring from 0 microns to 300 microns while maintaining focus.
  • the axicon prism system can be used to machine cones into the suture material at an angle. Cones of various diameters are used in a laser machining process to remove material from a filament.
  • the cone produced by the axicon pair is in some embodiments set to be near 0 diameter, progressively getting larger while the focus of the laser is translated into the suture removing a 3D cone shape of suture material (at a compound angle relative to a retainer to be formed).
  • the laser power is coordinated with the cone diameter to maintain a constant energy density in the ring regardless of ring diameter.
  • FIG. 2D shows a representative image of a laser beam 270 from an axicon prism system incident on a planar surface 278 .
  • the laser beam has a low power density at the center 272 .
  • the power density increases travelling away from center 272 until it peaks in ring 274 .
  • the power density then drops off rapidly moving outward from ring 274 .
  • the diameter D of ring 274 can be controlled by changing the distance between the axicon prisms.
  • the thickness T of the ring can be controlled using the lens between the axicon prisms to focus the ring.
  • FIG. 2E shows a graphical representation of the power density distribution of a laser beam (such as laser beam 270 of FIG. 2D ) from an axicon prism system, where the axicon prism essentially creates an energy distribution having a profile in the form of an annular ring.
  • FIG. 3A shows a sectional view of an embodiment of a stabilization device 248 for stabilizing suture thread 204 adjacent the laser beam 202 (see FIG. 2A ).
  • the stabilization device 248 reduces movement of suture thread 204 adjacent the cutting region in order to enhance the accuracy of the laser machining operation (see FIG. 2A ).
  • a preferred embodiment of stabilization device 248 is an air bearing 300 which provides a stream of air to stabilize suture thread 304 without mechanically contacting suture thread 304 .
  • FIG. 3A shows a sectional view of an air bearing 300 which can be included in stabilization device 248 of FIG. 2A .
  • air bearing comprises an entry nozzle 310 and an exit nozzle 320 .
  • Entry nozzle 310 and exit nozzle 320 have tips 312 , 322 which have an inside diameter as close as possible to the diameter of the suture without running the risk of making physical contact.
  • the inside diameter may be 1.5, 2.0, 2.5 or 3.0 times the suture diameter, however as the inside diameter increases, there is a greater tendency for looseness in the fluid film bearing.
  • different nozzles are used for suture threads of different size.
  • Entry nozzle 310 and exit nozzle 320 can be made by drawing down a glass tube to the appropriate diameter for a particular suture thread and cutting and grinding the tip 312 , 322 .
  • An alternative and suitable air bearing is available from Newway Air Bearings (Aston, Pa.) which incorporates graphite porous media for the bearing and utilizes the air brushing approach in a size suitable for sutures.
  • exit nozzle 320 is mounted within a cavity 332 of a manifold 330 .
  • O-rings 340 , 342 seal exit nozzle 320 to the surface of cavity 332 .
  • Manifold 330 is machined to deliver pressurized air from an intake line 334 evenly around cavity 332 .
  • Entry nozzle 310 is positioned with tip 312 within the lumen of exit nozzle 320 as shown.
  • Entry nozzle 310 and exit nozzle 320 are positioned coaxially. Entry nozzle 310 is aligned and secured in position by entry cap 350 .
  • An o-ring 344 seals entry nozzle 310 to entry cap 350 .
  • Entry cap 350 has a chamfered entry port 352 which is positioned coaxial with entry nozzle 310 and exit nozzle 320 .
  • An exit cap 354 is mounted on the other end of manifold 330 .
  • Exit cap 354 has an exit port 356 through which exit nozzle 320 protrudes.
  • Entry cap 350 , manifold 330 and exit cap 354 are secured together by a plurality of fasteners 358 .
  • a suture thread 304 can be introduced through entry port 352 .
  • Suture thread 304 passes through entry nozzle 310 and then through exit nozzle 320 passing out of tip 322 of exit nozzle 320 as shown.
  • Pressurized air is introduced through intake 334 and passes into the cavity 332 of manifold 330 .
  • the pressurized air the passes into exit nozzle 320 and is forced out of tip 322 surrounding suture thread 304 . (Some air also leaks out through entry nozzle 310 ).
  • the fast moving air surrounding suture thread 304 operates as an air bearing stabilizing the position of suture thread 304 adjacent tip 322 without contacting suture thread 304 .
  • FIG. 3B shows a perspective view only of exit nozzle 320 and suture thread 304 .
  • pressurized air enters the lumen 324 of exit nozzle 320 (arrows 360 and is forced at high speed out of the narrow tip 322 of exit nozzle (arrows 362 ).
  • the stream of air within tip 322 stabilizes suture thread within the center of tip 322 and so suture thread does not contact the walls of exit nozzle 320 .
  • a stream of high speed air surrounds suture thread 304 as it exits tip 322 .
  • the tip is designed to produce laminar flow of air in this stream in an area adjacent the tip.
  • the high speed stream of air stabilizes the suture thread damping movement and vibration caused e.g. by the cutting process.
  • Pressure is exerted by slower moving gas on the outside of the high speed stream forcing suture thread 304 to the center of stream as shown by arrows 364 .
  • the suture thread 304 is stabilized by the air bearing in the region 370 adjacent tip 322 of exit nozzle 320 .
  • the air bearing 300 is positioned so that stabilization region 370 is positioned in the cutting zone of the laser.
  • the stream of air passing over suture thread 304 also serves to remove particulates and smoke from the laser cutting process and also cools the suture thread 304 during cutting by the laser.
  • the suture thread is passes out of the tip 332 of exit nozzle 320 for cutting of retainers in the stabilization zone. After cutting the retainers are moved away from exit nozzle 320 . It is preferred that the retainers not move into the exit nozzle as the high velocity air can damage the retainers, and the retainers can cause turbulence in the high velocity air destabilizing the suture thread in stabilization region 370 .
  • FIG. 4A is a flowchart of a method 400 for operating the laser machining system 200 of FIG. 2A .
  • the suture thread is mounted to the chucks of the transport system.
  • the suture thread should also be tensioned to a desired tension during the mounting step. The tension should be the same for each suture thread.
  • the control system operate the transport subsystem is operated to index and rotate the suture thread to the correct position for forming the first retainer.
  • the distribution/location of retainers is stored in a retainer distribution pattern data or program file.
  • the control subsystem selects the correct retainer creation pattern for the indexed location on the suture thread.
  • the retainer creation pattern dictates the final orientation, shape and size of the retainer to be created at a particular location.
  • the laser machining system is then operated to form a retainer at the indexed location in accordance with the selected retainer creation pattern.
  • the transport system is operated to align a target volume of the suture thread with the laser.
  • the laser subsystem is operated to ablate/cut material in the target volume. Step 410 can also include validation of the ablation/cutting using the imaging subsystem.
  • the process returns to step 408 to operate the transport system to align a new target volume with the laser in accordance with the retainer creation pattern.
  • the process moves on to step 414 .
  • the imaging subsystem is operated to image the completed retainer and provide the image data to the control subsystem.
  • the control subsystem uses the image data to validate that the retainer is within the tolerances defined by the retainer creation pattern. If the retainer cannot be validated, the control system can do one or more of: operate the transport subsystem and laser subsystem to correct the defect; fail the particular suture thread; mark an exception with respect to the suture thread for further inspection; set an alert for a human operator; and/or shut down operation of the laser-machining system. If the retainer is validated within tolerances at step 414 the process moves on to step 416 .
  • step 416 if further retainers remain to be created, the process return to step 404 for indexing the suture thread to the next position for creating a retainer. At step 416 , if all retainers have been completed, the process moves to step 418 . At step 418 the suture thread is complete and is unloaded from the chucks.
  • FIGS. 4B-4D further illustrate steps in the process of forming a retainer according to the method of FIG. 4A .
  • the suture thread 424 is moved longitudinally 430 , laterally ( 432 ) and axially ( 434 ) by the transport subsystem to align the laser beam 426 with a target volume of the suture thread 424 .
  • the laser subsystem is then operated to ablate material from the suture thread 424 , generating a cavity or slot 428 .
  • cavity 428 is larger in diameter than laser beam 426 .
  • a laser beam 3 nm in diameter generates a cavity of approximately 7 nm in diameter.
  • the suture thread 424 is moved longitudinally 430 and laterally 432 stepwise to a series of positions aligning new target volumes with the laser beam to generate a series of cavities through suture thread 424 .
  • the target volumes are dictated by the suture creation pattern. Note that it is preferable to make interior cuts to form the tissue engagement surface of the retainer prior to cutting the tip of the retainer.
  • FIG. 4D shows the completed retainer 440 having a tip 442 and retainer engagement surface 444 .
  • tip 442 is not elevated above the surface of suture thread 424 .
  • Post-cut processing can be carried out in some cases to elevate the tip above the surface of the suture thread 424 .
  • the retainer 440 is designed to be effective without elevation of the retainer tip 442 above the original surface of the suture thread 424 .
  • the same steps are repeated for the remaining retainers on suture thread 424 .
  • different configurations and orientations of retainer can be created at different locations on the suture using a different retainer creation pattern without requiring a different cutting head or reloading the suture thread.
  • An advantage of utilizing a laser-machining system to create retainers is the ability to form retainers in configurations that are difficult and/or impossible to make using mechanical cutting with a blade.
  • FIG. 5 shows an image of the examined laser cut surface 922 machined into a suture thread 920 .
  • FIG. 6 shows a graph of the profile of laser-cut surface viewed laterally. The laser machining system is shown to make laser-cut surfaces of high flatness and uniformity with high precision and repeatability to create a self-retaining suture.
  • FIG. 7 show a range of retainer distributions and patterns that can be created using the laser machining system.
  • FIG. 7 shows a single helix distribution which may be cut with the laser machining system of the present invention.
  • the laser-cut retainers can have any laser-cut retainer configuration described herein and/or different laser-cut retainer configurations can be present at different points of the self-retaining suture. Note also that the laser machining system of the present invention is capable of creating non-uniform retainer distributions along a single suture thread if advantageous for a particular self-retaining suture application.
  • FIG. 7 shows a single helix distribution of laser-cut retainers 704 on a self-retaining suture 700 .
  • the self-retaining suture 700 has a filament 702 which is of USP 2-0, 4-0, 6-0, 7-0, 8-0, 9-0, 10-0, 11-0, 12-0 or below.
  • the filament is 0.25 mm in diameter which is a 4-0 suture.
  • the self-retaining suture 700 includes a plurality of laser-cut retainers 704 arranged in a helical pattern around and along the filament 702 .
  • the helix has a pitch of 4.46 mm (or 5.7 twists per inch).
  • the self-retaining suture has a barbed section 712 at least 70 mm in length and a 100 mm unbarbed lead 710 , 714 on either side of the barbed section 712 .
  • the barbed section 712 may have retainers 704 in one orientation or in different orientations. Note that because the laser machining system is contactless, retainer distribution patterns can be designed without limitations imposed by the need to support a suture without impairing already cut retainers during mechanical cutting. Thus, for example, in some embodiments, the pitch can be less than the length of a retainer.
  • retainer distribution patterns can be designed without limitations imposed by the need to support a suture without impairing already cut retainers during mechanical cutting.
  • the pitch can be less than the length of a retainer.
  • FIGS. 8A-8B are images of examples of laser-cut retainers created with the laser cutting system of FIG. 2A .
  • Self-retaining sutures comprising suture threads with a plurality of laser-cut retainers thereon made to test the capabilities of a laser-machining system in accordance with FIG. 2A .
  • the suture threads were, in each case blue-colored propylene filaments.
  • FIG. 8A shows an image of 2-0 polypropylene suture 820 having laser-cut retainers 822 thereon.
  • Laser-cut retainers 822 have a straight cut configuration and are distributed in a double-helix distribution. After the retainers 822 were cut, the suture 820 was heat treated for five minutes at 155 C while under 32 grams of tension to elevate the retainers 822 .
  • FIG. 8B shows an image of 10-0 polypropylene suture 800 having laser-cut retainers 802 thereon.
  • Laser-cut retainers 802 have a straight cut configuration.
  • FIG. 8C shows an image of a polypropylene suture 860 having laser-cut retainers 862 thereon.
  • Laser-cut retainers 862 have a straight cut configuration and are distributed in a double-helix distribution.
  • the suture 860 was heat treated for five minutes at 155 C to elevate the retainers 862 .
  • the resulting parameters L 1 -L 5 of suture 860 were then measured under a microscope.
  • the suture diameter L 1 was 101.8 nm; the cut length L 2 was 99.5 nm; the cut depth L 3 was 34.5 nm; the elevation L 4 of the tip of the retainer above the surface of the filament was 15.8 nm; and the distance L 5 between adjacent retainers was 118.3 nm.
  • FIG. 8D shows an image of a polypropylene suture 870 having laser-cut retainers 872 thereon.
  • Laser-cut retainers 872 have a straight cut configuration and are distributed in a double-helix distribution.
  • the suture 870 was heat treated for five minutes at 155 C to elevate the retainers 872 .
  • the resulting parameters L 1 -L 4 and AN 1 of suture 870 were then measured under a microscope.
  • the suture diameter L 3 was 103.8 nm; the cut depth L 2 was 29.7 nm; the elevation L 1 of the tip of the retainer above the surface of the filament was 14.6 nm; the distance L 4 between adjacent retainers was 131.3 nm; and the angle AN 1 was 14.3 degrees.
  • FIG. 8E shows an image of a polypropylene suture 880 having laser-cut retainers 882 thereon.
  • Laser-cut retainers 882 have a straight cut configuration and are distributed in a double-helix distribution. After the retainers 882 were cut, the suture 880 was heat treated for five minutes at 155 C to elevate the retainers 882 . The resulting parameters L 1 -L 6 of suture 880 were then measured under a microscope.
  • the suture diameter L 6 was 93.3 nm; the width L 1 of the retainer base was 77.6 nm; the cut length L 3 was 69.2 nm; the cut depth L 4 was 28.5 nm; the elevation L 5 of the tip of the retainer above the surface of the filament was 14.6 nm; and the distance L 2 between adjacent retainers was 89.1 nm.
  • FIG. 8F shows an image of a polypropylene suture 890 having laser-cut retainers 892 thereon.
  • Laser-cut retainers 892 have a straight cut configuration and are distributed in a double-helix distribution. After the retainers 892 were cut, the suture 890 was heat treated for five minutes at 155 C to elevate the retainers 892 . The resulting parameters L 1 -L 6 and AN 1 of suture 890 were then measured under a microscope.
  • the suture diameter L 5 was 96.5 nm; the width L 6 of the retainer base was 83.4 nm; the cut length L 1 was 107.9 nm; the cut depth L 2 was 37.0 nm; the elevation L 3 of the tip of the retainer above the surface of the filament was 21.2 nm; the distance L 4 between adjacent retainers was 117.2 nm; and angle An 1 was 18 degrees.
  • Suture threads described herein may be produced by any suitable method, including without limitation, injection molding, stamping, cutting, laser, extrusion, and so forth.
  • the suture threads described herein may use any material conventionally used for the manufacture of sutures including for example, metals and metal alloys, polymers including non-degradable polymers and biodegradable polymers, and natural materials.
  • polymeric suture threads/filaments may be manufactured or purchased for the suture body, and the retainers can be subsequently cut onto the suture body.
  • either the laser beam or the suture thread may be moved relative to the other, or both may be moved, to control the size, shape and depth of the retainers.
  • Suitable suture materials include: degradable suture materials, non-degradable suture materials, natural suture materials, recombinant suture materials and metallic suture materials.
  • Degradable suture materials also referred to as “biodegradable suture” or “absorbable suture” are those which, after introduction into a tissue are broken down and absorbed by the body. Typically, the degradation process is at least partially mediated by, or performed in, a biological system. “Degradation” refers to a chain scission process by which a polymer chain is cleaved into oligomers and monomers.
  • Chain scission may occur through various mechanisms, including, for example, by chemical reaction (e.g., hydrolysis, oxidation/reduction, enzymatic mechanisms or a combination of these) or by a thermal or photolytic process.
  • Polymer degradation is, in some embodiments, characterized, for example, using gel permeation chromatography (GPC), which monitors the polymer molecular mass changes during erosion and breakdown.
  • GPC gel permeation chromatography
  • Non-degradable suture materials also referred to as “non-absorbable suture” are those which are not degraded by chain scission such as chemical reaction processes (e.g., hydrolysis, oxidation/reduction, enzymatic mechanisms or a combination of these) or by a thermal or photolytic process.
  • Degradable suture materials include polymers for example polyglycolic acid, copolymers of glycolide and lactide, copolymers of trimethylene carbonate and glycolide with diethylene glycol (e.g., MAXONTM, Tyco Healthcare Group), terpolymer composed of glycolide, trimethylene carbonate, and dioxanone (e.g., BIOSYNTM [glycolide (60%), trimethylene carbonate (26%), and dioxanone (14%)], Tyco Healthcare Group), copolymers of glycolide, caprolactone, trimethylene carbonate, and lactide (e.g., CAPROSYNTM, Tyco Healthcare Group).
  • a dissolvable suture can also include partially deacetylated polyvinyl alcohol.
  • Polymers suitable for use in degradable sutures can be linear polymers, branched polymers or multi-axial polymers. Examples of multi-axial polymers used in sutures are described in U.S. Patent Application Publication Nos. 2002/0161168, 2004/0024169, and 2004/0116620. Sutures made from degradable suture material lose tensile strength as the material degrades. Degradable sutures can be in either a braided multifilament form or a monofilament form.
  • Non-degradable suture materials include, for example, polyamide (also known as nylon, such as nylon 6 and nylon 6,6), polyester (e.g., polyethylene terephthlate), polytetrafluoroethylene (e.g., expanded polytetrafluoroethylene), polyether-ester such as polybutester (block copolymer of butylene terephthalate and polytetra methylene ether glycol), polyurethane, metal alloys, metal (e.g., stainless steel wire), polypropylene, polyethelene, silk, and cotton.
  • Sutures made of non-degradable suture material are suitable for applications in which the suture is meant to remain permanently in the body or is meant to be physically removed from the body after it has served its intended purpose.
  • self-retaining sutures can be used in a variety of other indications.
  • Self-retaining sutures described herein may be used in various dental procedures, i.e., oral and maxillofacial surgical procedures and thus may be referred to as “self-retaining dental sutures.”
  • the above-mentioned procedures include, but are not limited to, oral surgery (e.g., removal of impacted or broken teeth), surgery to provide bone augmentation, surgery to repair dentofacial deformities, repair following trauma (e.g., facial bone fractures and injuries), surgical treatment of odontogenic and non-odontogenic tumors, reconstructive surgeries, repair of cleft lip or cleft palate, congenital craniofacial deformities, and esthetic facial surgery.
  • Self-retaining dental sutures may be degradable or non-degradable, and may typically range in size from USP 2-0 to USP 6-0.
  • Self-retaining sutures described herein may also be used in tissue repositioning surgical procedures and thus may be referred to as “self-retaining tissue repositioning sutures”. Such surgical procedures include, without limitation, face lifts, neck lifts, brow lifts, thigh lifts, and breast lifts. Self-retaining sutures used in tissue repositioning procedures may vary depending on the tissue being repositioned; for example, sutures with larger and further spaced-apart retainers may be suitably employed with relatively soft tissues such as fatty tissues.
  • Self-retaining sutures described herein may also be used in microsurgical procedures that are performed under a surgical microscope (and thus may be referred to as “self-retaining microsutures”). Such surgical procedures include, but are not limited to, reattachment and repair of peripheral nerves, spinal microsurgery, microsurgery of the hand, various plastic microsurgical procedures (e.g., facial reconstruction), microsurgery of the male or female reproductive systems, and various types of reconstructive microsurgery. Microsurgical reconstruction is used for complex reconstructive surgery problems when other options such as primary closure, healing by secondary intention, skin grafting, local flap transfer, and distant flap transfer are not adequate.
  • Self-retaining microsutures have a very small caliber, often as small as USP 9-0, USP 10-0, USP 11-0 or USP 12-0, and may have an attached needle of corresponding size.
  • the microsutures may be degradable or non-degradable.
  • Self-retaining sutures as described herein may be used in similarly small caliber ranges for ophthalmic surgical procedures and thus may be referred to as “ophthalmic self-retaining sutures”. Such procedures include but are not limited to keratoplasty, cataract, and vitreous retinal microsurgical procedures. Ophthalmic self-retaining sutures may be degradable or non-degradable, and have an attached needle of correspondingly-small caliber. In addition, the self-retaining sutures disclosed herein can be used in a variety of veterinary applications for a wide number of surgical and traumatic purposes in animal health.
  • the present invention includes, in some embodiments, laser cutting systems, components and methods as identified in the following numbered paragraphs:
  • a method for making a self-retaining suture comprising;
  • step (c) comprises
  • step (b) comprises directing a laser beam at the tissue retainer location on the suture thread and focusing the laser beam to a diameter no greater than 5 ⁇ m.
  • step (b) comprises directing a femtosecond laser beam at the tissue retainer location on the suture thread.
  • step (b) comprises directing a femtosecond laser beam comprising infrared wavelengths at the tissue retainer location on the suture thread.
  • step (b) comprises directing a femtosecond laser beam comprising ultraviolet wavelengths at the tissue retainer location on the suture thread.
  • a laser subsystem adapted to provide a laser beam
  • an optic system adapted to receive the laser beam and generate a focused laser beam directed at a volume of the suture thread
  • a transport subsystem adapted to move the suture thread relative to the laser beam
  • an imaging subsystem adapted to image the suture thread and generate image data
  • control subsystem adapted to receive said image data from the laser subsystem and transport subsystem to create a tissue retainer of a selected configuration at a selected location on said suture thread.
  • the laser subsystem comprises a femtosecond laser.
  • the laser subsystem comprises a UV laser.
  • the laser subsystem comprises an IR laser.
  • the laser subsystem is adapted to provide a laser beam including IR and UV wavelengths.
  • control subsystem provides focus control signals to the optical subsystem in response to the image data
  • the optic subsystem is adapted to change the focus depth of the laser beam in response to the focus control signals.
  • control system is adapted to analyze the image data and verify that the tissue retainer is within design tolerances for the selected configuration.
  • the laser-machining system of paragraph 126 further comprising a stabilization device adapted to stabilize the suture thread adjacent the selected location.
  • the laser-machining system of paragraph 126 further comprising a stabilization device adapted to stabilize the suture thread adjacent the selected location without mechanical contact with the suture thread.
  • the laser-machining system of paragraph 126 further comprising a fluid bearing adapted to stabilize the suture thread adjacent the selected location.
  • the laser-machining system of paragraph 126 further comprising an air bearing device which provides a high speed laminar flow of fluid along and surrounding the suture thread at the selected location.
  • the optic subsystem includes one or more axicon prisms.
  • the laser beam has a Gaussian power density distribution.
  • the laser beam has a ring-shaped power density distribution of selectable ring diameter.
  • a stabilization device for contactless stabilization of a suture thread in a region of the suture thread wherein the stabilization device comprises:
  • a fluid outlet connected to the source of pressurized fluid and adapted to generate a laminar flow of fluid along the suture thread and surrounding the suture thread in the region of the suture thread.
  • the fluid outlet is nozzle-shaped.
  • the suture thread passes through the fluid outlet.
  • fluid manifold wherein the fluid manifold is connected to the source of pressurized fluid and the fluid outlet is connected to one end of the fluid manifold;
  • the stabilization device is configured such that a suture thread can enter the fluid manifold through an entry port and leave the fluid manifold through the fluid outlet without contacting the entry port and fluid outlet.
  • the stabilization device of paragraph 140 in combination with a machining system adapted to direct a laser beam at the suture thread to create a tissue retainer in the region of the suture thread.
  • the stabilization device of paragraph 140 in combination with a laser-machining system comprising:
  • a laser subsystem adapted to provide a laser beam
  • an optic system adapted to receive the laser beam and generate a focused laser beam directed at a volume of the suture thread
  • a transport subsystem adapted to move the suture thread relative to the laser beam
  • an imaging subsystem adapted to image the suture thread and generate image data
  • control subsystem adapted to control the laser subsystem and transport subsystem to create a tissue retainer of a selected configuration in the region of the suture thread.
  • a method for creating a self-retaining suture comprising:
  • a laser subsystem adapted to provide a laser beam
  • an optic system adapted to receive the laser beam and generate a focused laser beam directed at a volume of the suture thread
  • a transport subsystem adapted to move the suture thread relative to the focused laser beam
  • a marking subsystem adapted to change a visual characteristic of a selected region of the suture thread without ablating suture material
  • control subsystem adapted to control the laser subsystem, marking subsystem, and transport subsystem to create a tissue retainer of a selected configuration at a selected location on said suture thread and create a visible marker on the suture thread at a different selected location on said suture thread.
  • a method for making a self-retaining suture comprising;
  • step (e) comprises treating the self-retaining suture with heat to elevate the tips of the plurality of tissue retainers so that the tips protrude from the suture thread.
  • step (e) comprises treating the self-retaining suture with tension to elevate the tips of the plurality of tissue retainers so that the tips protrude from the suture thread.
  • step (e) comprises treating the self-retaining suture with heat and tension to elevate the tips of the plurality of tissue retainers so that the tips protrude from the suture thread.
  • a method for making a self-retaining suture comprising;
  • step (c) comprises identifying a second volume of suture material from within the first volume of suture material the second volume being less than 50% of the first volume.
  • step (c) comprises identifying a second volume of suture material from within the first volume of suture material the second volume being less than 25% of the first volume.
  • step (c) comprises identifying a conical subvolume of suture material from within the volume of suture material wherein the subvolume of suture material;
  • step (d) comprises directing a laser beam at the suture thread to ablate all of the suture material within the selected volume of suture material with the exception of the conical subvolume of suture material whereby the conical subvolume of suture material forms a tissue retainer protruding from laser cut surface of the suture thread.
  • step (a) comprises providing a suture thread having a surface and a noncircular cross-section.
  • step (a) comprises providing a suture thread having a surface and a plurality of longitudinal ridges noncircular cross-section;
  • step (b) comprises identifying a first volume of suture material on the surface of the thread within one of the longitudinal ridges.
  • step (a) comprises providing a suture thread having a surface and a polygonal cross section having a plurality of longitudinal apices;
  • step (b) comprises identifying a first volume of suture material on the surface of the thread including one of the longitudinal apices.

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Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110166597A1 (en) * 2007-09-27 2011-07-07 Angiotech Pharmaceuticals, Inc. Self-retaining sutures including tissue retainers having improved strength
US8915943B2 (en) 2007-04-13 2014-12-23 Ethicon, Inc. Self-retaining systems for surgical procedures
US8916077B1 (en) 2007-12-19 2014-12-23 Ethicon, Inc. Self-retaining sutures with retainers formed from molten material
US9044225B1 (en) 2007-12-20 2015-06-02 Ethicon, Inc. Composite self-retaining sutures and method
US20160270776A1 (en) * 2015-03-16 2016-09-22 Edwards Lifesciences Corporation Suture securement devices
US9675341B2 (en) 2010-11-09 2017-06-13 Ethicon Inc. Emergency self-retaining sutures and packaging
US9955962B2 (en) 2010-06-11 2018-05-01 Ethicon, Inc. Suture delivery tools for endoscopic and robot-assisted surgery and methods
US10188384B2 (en) 2011-06-06 2019-01-29 Ethicon, Inc. Methods and devices for soft palate tissue elevation procedures
US10420546B2 (en) 2010-05-04 2019-09-24 Ethicon, Inc. Self-retaining systems having laser-cut retainers
US10492780B2 (en) 2011-03-23 2019-12-03 Ethicon, Inc. Self-retaining variable loop sutures
US10548592B2 (en) 2004-05-14 2020-02-04 Ethicon, Inc. Suture methods and devices
US11007296B2 (en) 2010-11-03 2021-05-18 Ethicon, Inc. Drug-eluting self-retaining sutures and methods relating thereto
US11376689B2 (en) * 2016-04-25 2022-07-05 Precitec Gmbh & Co. Kg Beam forming lens system for laser cutting, and apparatus comprising same
US11413112B2 (en) * 2017-10-13 2022-08-16 Viscus Biologics, Llc Radiopaque tissue marker
US20220364848A1 (en) * 2021-05-13 2022-11-17 Industrial Technology Research Institute Depth measurement apparatus and depth measurement method
US11554446B2 (en) * 2017-06-09 2023-01-17 Bystronic Laser Ag Beam shaper and use thereof, device for laser beam treatment of a workpiece and use thereof, method for laser beam treatment of a workpiece
US11819709B2 (en) 2019-02-14 2023-11-21 Videra Surgical Inc. Fiducial marker for oncological and other procedures

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8795332B2 (en) 2002-09-30 2014-08-05 Ethicon, Inc. Barbed sutures
US6773450B2 (en) 2002-08-09 2004-08-10 Quill Medical, Inc. Suture anchor and method
BRPI0820129B8 (pt) 2007-12-19 2021-06-22 Angiotech Pharm Inc processo de formação de uma sutura autorretentora e sutura autorretentora
WO2009097556A2 (en) 2008-01-30 2009-08-06 Angiotech Pharmaceuticals, Inc. Appartaus and method for forming self-retaining sutures
WO2009105663A2 (en) 2008-02-21 2009-08-27 Angiotech Pharmaceuticals, Inc. Method and apparatus for elevating retainers on self-retaining sutures
MX339174B (es) 2008-11-03 2016-05-12 Ethicon Llc Longitud de sutura autorretenible y metodo y dispositivo para su uso.
WO2011090628A2 (en) 2009-12-29 2011-07-28 Angiotech Pharmaceuticals, Inc. Bidirectional self-retaining sutures with laser-marked and/or non-laser marked indicia and methods
ITRM20100121A1 (it) * 2010-03-18 2011-09-19 Univ Pisa Marcatori molecolari per infezioni delle vie urinarie.
US9687227B2 (en) * 2011-04-29 2017-06-27 Covidien Lp Apparatus and method of forming barbs on a suture
US10463361B2 (en) * 2012-07-13 2019-11-05 The University Of North Carolina At Charlotte Selective laser vaporization of materials
KR101550103B1 (ko) * 2013-11-07 2015-09-03 김춘동 수술용 실의 돌기 형성장치 및 그 방법
US10052105B2 (en) * 2013-11-18 2018-08-21 Ethicon, Inc. Recessed surgical fastening devices
KR102332026B1 (ko) * 2014-01-27 2021-12-01 에디컨인코포레이티드 비대칭 리테이너를 갖는 자가-유지형 봉합 기구 및 이를 제조하는 방법
IN2014CH00782A (xx) * 2014-02-19 2015-08-28 Kennametal India Ltd
US11638640B2 (en) 2014-06-11 2023-05-02 Bard Shannon Limited In vivo tissue engineering devices, methods and regenerative and cellular medicine employing scaffolds made of absorbable material
US10595986B2 (en) * 2014-06-11 2020-03-24 Robert D. Rehnke Internal long term absorbable matrix brassiere and tissue engineering scaffold
US11883275B2 (en) * 2014-06-11 2024-01-30 Bard Shannon Limited In vivo tissue engineering devices, methods and regenerative and cellular medicine employing scaffolds made of absorbable material
WO2016025329A1 (en) * 2014-08-15 2016-02-18 Tepha, Inc. Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof
KR101591367B1 (ko) * 2014-12-02 2016-02-03 최규석 봉합사 코그 성형장치
USD867591S1 (en) * 2016-04-12 2019-11-19 Jason P. Adams Single strand mono-directional barb loop suture with single coating shield
USD865176S1 (en) * 2016-04-12 2019-10-29 Jason P. Adams Double strand bi-directional barb suture with single coating shield
USD869656S1 (en) * 2016-04-12 2019-12-10 Jason P. Adams Single strand bi-directional barb suture with coating shield
USD870283S1 (en) * 2016-04-12 2019-12-17 Jason P. Adams Single strand bi-directional suture with coating shield
USD872861S1 (en) * 2016-04-12 2020-01-14 Jason P. Adams Double strand twist bi-directional barb suture with single coating shield
USD870282S1 (en) * 2016-04-12 2019-12-17 Jason P. Adams Single strand bi-directional barb suture with coating shield
US10206675B2 (en) 2016-07-13 2019-02-19 Ethicon Llc Method and apparatus for fabricating self-retaining sutures with calibration
CN106249405B (zh) * 2016-10-10 2018-10-26 同济大学 旋转三棱镜光束扫描装置
CN106388891A (zh) * 2016-10-10 2017-02-15 上海百玫医疗科技有限公司 一种手术缝线及其加工方法
KR101941659B1 (ko) * 2017-02-09 2019-03-04 주식회사 메디셀러 의료용 봉합사의 제조 장치 및 제조 방법
DE102018201596A1 (de) * 2018-02-02 2019-08-08 Forschungsverbund Berlin E.V. Verfahren und Vorrichtung zur direkten Strukturierung mittels Laserstrahlung
US11844682B2 (en) 2018-03-12 2023-12-19 Bard Shannon Limited In vivo tissue engineering devices, methods and regenerative and cellular medicine employing scaffolds made of absorbable material
US11478878B2 (en) 2018-09-28 2022-10-25 Synfuel Americas Corporation Laser cutting system for cutting articles and forming filtration tubes
EP3721813A1 (en) * 2019-04-12 2020-10-14 B. Braun Surgical S.A. Wound closure device
USD909578S1 (en) * 2019-08-06 2021-02-02 Healthium Medtech Private Limited Surgical suture
CA3153882A1 (en) * 2019-10-31 2021-05-06 Ho Sung Lee Medical suture and method for producing same
BR122023022155A2 (pt) 2020-03-23 2024-02-20 Bard Shannon Limited Prótese implantável que compreende corpo de material biocompatível
CN111700707A (zh) * 2020-06-29 2020-09-25 杭州爱普医疗器械股份有限公司 火箭形锯齿线
KR102456091B1 (ko) * 2020-10-30 2022-10-19 삼일테크(주) 수직형 와이어 미늘 성형장치
EP3995283B1 (en) * 2020-11-10 2023-10-11 Gerresheimer Regensburg GmbH Laser cutting of microinjection moulded parts
CN115444612A (zh) * 2021-04-02 2022-12-09 苏州大学 一种倒刺蚕丝缝合线
KR102683579B1 (ko) * 2022-01-06 2024-07-10 김태영 봉합사의 레이저 각인장치

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5931855A (en) * 1997-05-21 1999-08-03 Frank Hoffman Surgical methods using one-way suture
US20070005110A1 (en) * 2005-06-29 2007-01-04 Collier John P Braided barbed suture
US20080128397A1 (en) * 2006-11-06 2008-06-05 Unidym, Inc. Laser patterning of nanostructure-films
US20090012560A1 (en) * 2007-04-13 2009-01-08 Angiotech Pharmaceuticals, Inc. Self-retaining systems for surgical procedures
US20090200487A1 (en) * 2008-02-13 2009-08-13 Tyco Healthcare Group Lp Methods of Altering Surgical Fiber

Family Cites Families (840)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3123077A (en) 1964-03-03 Surgical suture
US709392A (en) 1902-05-06 1902-09-16 Haydn Brown Suture-clamp.
US733723A (en) 1903-02-16 1903-07-14 Clarence D Lukens Serrefin.
US816026A (en) 1905-03-09 1906-03-27 Albert J Meier Surgical clip.
US1142510A (en) 1914-11-04 1915-06-08 Lillian K Engle Fastening device.
GB267007A (en) 1926-09-04 1927-03-10 Mayr Alfred Improvements in containers for surgical suture material
US1728316A (en) 1927-07-02 1929-09-17 Kirurgiska Instr Fabriks Aktie Wound clasp
US1886721A (en) 1928-08-10 1932-11-08 Rubber Products Corp Road marker
US2094578A (en) 1932-09-13 1937-10-05 Blumenthal Bernhard Material for surgical ligatures and sutures
US2201610A (en) 1938-05-20 1940-05-21 Jr James C Dawson Wound clip
US2254620A (en) 1939-11-14 1941-09-02 George I Miller Clip
US2232142A (en) 1940-09-27 1941-02-18 Schumann Seymour Wound clip
US2347956A (en) 1943-02-06 1944-05-02 Earl P Lansing Cable sheath cutting and stripping tool
US2421193A (en) 1943-08-02 1947-05-27 Cleveland Clinic Foundation Surgical dressing
US2355907A (en) 1943-11-12 1944-08-15 Johnson & Johnson Method and apparatus for grinding and polishing ligatures
US2480271A (en) 1945-02-27 1949-08-30 Sumner Thomas Soap dispenser with reciprocating cutter blade
US2472009A (en) 1945-08-01 1949-05-31 Cleveland Clinic Foundation Surgical dressing
US2452734A (en) 1945-10-26 1948-11-02 John F Costelow Insulation cutter
US2572936A (en) 1947-02-27 1951-10-30 American Viscose Corp Process for making crimped artificial filaments
US2591063A (en) 1949-05-14 1952-04-01 Goldberg Harry Surgical suture
US2910067A (en) 1952-10-13 1959-10-27 Technical Oil Tool Corp Wound clip and extractor therefor
US2684070A (en) 1953-03-23 1954-07-20 Walter L Kelsey Surgical clip
US2817339A (en) 1953-08-10 1957-12-24 Norman M Sullivan Rigid fascial suture
US2736964A (en) 1954-05-18 1956-03-06 Lieberman Frank Chiropodist's knife
US2779083A (en) 1955-02-09 1957-01-29 Edward N Eaton Lip and mouth adjuster
US2830366A (en) 1955-08-11 1958-04-15 Ernest F Chisena Cutting implements for electric cables
US2866256A (en) 1956-04-05 1958-12-30 Rohm & Haas Wool-like artificial fibers
US3003155A (en) 1956-07-06 1961-10-10 Felix C Mielzynski Hair darts for implanting in live or artificial media
US2988028A (en) 1956-08-13 1961-06-13 John H Alcamo Surgeon's suturing device
US2928395A (en) 1957-06-20 1960-03-15 Ethicon Inc Sutures
US3066673A (en) 1959-04-23 1962-12-04 American Cyanamid Co Surgical sutures
US3066452A (en) 1959-04-23 1962-12-04 American Cyanamid Co Precision grinding of surgical sutures
US3068869A (en) 1959-10-01 1962-12-18 Sheiden Charles Hunter Tissue suture clamp
US3273562A (en) 1960-02-24 1966-09-20 Rene G Le Vaux Skin and surgical clips
US3068870A (en) 1960-03-18 1962-12-18 Levin Abraham Wound clip
US3209652A (en) 1961-03-30 1965-10-05 Burgsmueller Karl Thread whirling method
US3209754A (en) 1961-08-10 1965-10-05 Ernest C Wood Surgical clip
US3082523A (en) 1961-09-26 1963-03-26 Imp Eastman Corp Stripping tool
US3234636A (en) 1962-03-19 1966-02-15 Ernest C Wood Clip applicator
US3187752A (en) 1962-04-27 1965-06-08 American Cyanamid Co Non-absorbable silicone coated sutures and method of making
US3166072A (en) 1962-10-22 1965-01-19 Jr John T Sullivan Barbed clips
US3221746A (en) 1963-01-25 1965-12-07 Noble John William Surgical connecting device
US3212187A (en) 1963-03-27 1965-10-19 Bard Parker Company Inc Suture cutting and removing instrument
US3214810A (en) 1963-05-23 1965-11-02 Robert V Mathison Fastener devices
GB1091282A (en) 1963-07-09 1967-11-15 Nat Res Dev Sutures
US3206018A (en) 1963-07-10 1965-09-14 Ethicon Inc Wire suturing device
US3352191A (en) 1965-04-23 1967-11-14 Allan H Crawford Dowel
US3378010A (en) 1965-07-28 1968-04-16 Coldling Surgical clip with means for releasing the clamping pressure
US3385299A (en) 1965-10-23 1968-05-28 New Res And Dev Lab Inc Wound clip
US3452910A (en) 1967-07-17 1969-07-01 Leesona Corp Yarn handling apparatus
US3525340A (en) 1967-10-31 1970-08-25 Joseph G Gilbert Surgical dressing with skin clips thereon
DE1660592B2 (de) * 1967-12-09 1975-01-23 Plutte, Koecke & Co, 5600 Wuppertal Blasstrahldüse zum Fördern und/oder Behandeln textiler Fadengebilde
US3586002A (en) 1968-01-08 1971-06-22 Ernest C Wood Surgical skin clip
US3494006A (en) 1968-01-12 1970-02-10 George C Brumlik Self-gripping fastening device
US3522637A (en) 1968-03-06 1970-08-04 George C Brumlik Self-gripping fastening filament
FR1582147A (xx) 1968-05-22 1969-09-26
US3557795A (en) 1968-06-19 1971-01-26 Weck & Co Inc Edward Suture provided with wound healing coating
US3545608A (en) 1968-06-28 1970-12-08 Ethicon Inc Suture package
AT326803B (de) 1968-08-26 1975-12-29 Binder Fa G Maschenware sowie verfahren zur herstellung derselben
US3608539A (en) 1968-11-06 1971-09-28 Daniel G Miller Method for the biopsy of subcutaneous masses
DE1810800A1 (de) 1968-11-25 1970-06-04 Dr Med Gerhard Metz Spezialdraehte und -nadeln fuer die Sehnennaht
US3570497A (en) 1969-01-16 1971-03-16 Gerald M Lemole Suture apparatus and methods
US3833972A (en) 1969-09-11 1974-09-10 G Brumlik Self-adhering fastening filament
US3618447A (en) 1969-09-15 1971-11-09 Phillips Petroleum Co Deterioration fasteners
US3646615A (en) 1970-01-26 1972-03-07 Richard A Ness Reinforcing element for muscles
US3608095A (en) 1970-03-05 1971-09-28 Federal Tool Eng Co Method of fixing hair pieces to scalps
FR2084475A5 (xx) 1970-03-16 1971-12-17 Brumlik George
CH521459A (fr) 1970-03-20 1972-04-15 Sobico Inc Fil textile et procédé pour sa fabrication
CH515699A (fr) 1970-04-29 1971-11-30 Velcro Sa Soulie Article en forme de nappe à éléments d'accrochage multiples
US3683926A (en) 1970-07-09 1972-08-15 Dainippon Pharmaceutical Co Tube for connecting blood vessels
US3716058A (en) 1970-07-17 1973-02-13 Atlanta Res Inst Barbed suture
CH539572A (de) * 1971-06-18 1973-07-31 Luwa Ag Textilmaschine mit pneumatischer Hilfseinrichtung
US4008303A (en) 1971-08-30 1977-02-15 American Cyanamid Company Process for extruding green polyglycolic acid sutures and surgical elements
US3889322A (en) 1971-10-22 1975-06-17 Ingrip Fasteners Multi-element self-gripping device
US4198734A (en) 1972-04-04 1980-04-22 Brumlik George C Self-gripping devices with flexible self-gripping means and method
US4182340A (en) 1972-05-12 1980-01-08 Spencer Dudley W C Hoof repair
US3762418A (en) 1972-05-17 1973-10-02 W Wasson Surgical suture
US3922455A (en) 1972-05-23 1975-11-25 Ingrip Fasteners Linear element with grafted nibs and method therefor
CH545364A (de) * 1972-05-29 1973-12-15 Rueti Ag Vormals C Honegger Ma Düse zum Erzeugen eines Strahles eines Fluidums
US3847156A (en) 1972-07-17 1974-11-12 Sherwood Medical Ind Inc Suture
AU476672B2 (en) 1972-07-24 1976-09-30 Ethicon Inc. Braided suture dimension control
US3985138A (en) 1972-08-25 1976-10-12 Jarvik Robert K Preformed ligatures for bleeders and methods of applying such ligatures
US3825010A (en) 1973-04-23 1974-07-23 Donald B Mc Surgical apparatus for closing wounds
US3977937A (en) 1973-10-10 1976-08-31 Candor James T System for making a non-woven sheet by creating an electrostatic field action
US3980177A (en) 1973-10-26 1976-09-14 Johnson & Johnson Controlled release suture
US3918455A (en) 1974-04-29 1975-11-11 Albany Int Corp Combined surgical suture and needle
US3981307A (en) 1974-07-01 1976-09-21 Ethicon, Inc. Thermal attachment of surgical sutures to needles
US3941164A (en) 1975-02-13 1976-03-02 Musgrave Daniel D Process for making barbed material
US4006747A (en) 1975-04-23 1977-02-08 Ethicon, Inc. Surgical method
US3990144A (en) 1975-06-30 1976-11-09 Boris Schwartz Suture cutter and removal means
US4024871A (en) 1975-07-23 1977-05-24 Ethicon, Inc. Antimicrobial sutures
JPS5315191Y2 (xx) 1975-11-17 1978-04-21
GB1508627A (en) 1975-11-26 1978-04-26 Ethicon Inc Rapid closure suture
US4052988A (en) 1976-01-12 1977-10-11 Ethicon, Inc. Synthetic absorbable surgical devices of poly-dioxanone
US4069825A (en) 1976-01-28 1978-01-24 Taichiro Akiyama Surgical thread and cutting apparatus for the same
SU560599A2 (ru) 1976-02-02 1977-06-05 Устройство дл наложени хирургических швов
US4027608A (en) 1976-02-20 1977-06-07 Raymond Kelder Suturing device
USD246911S (en) 1976-02-27 1978-01-10 Bess Jr Kenneth B Automatic blind suturing machine
US4073298A (en) 1976-08-03 1978-02-14 New Research & Development Lab., Inc. Wound clip
CA1101289A (en) 1976-09-07 1981-05-19 Vsesojuzny Nauchno-Issledovatelsky I Ispytatelny Institut Meditsinskoi T Ekhniki Surgical apparatus for suturing soft tissues with lengths of suturing material with spicules
US4043344A (en) 1976-09-20 1977-08-23 American Cyanamid Company Non-absorbable surgical sutures coated with polyoxyethylene-polyoxypropylene copolymer lubricant
US4186239A (en) 1976-12-06 1980-01-29 Berkley & Company, Inc. Monofilament weed cutters
SU715082A1 (ru) 1977-01-24 1980-02-15 Всесоюзный научно-исследовательский и испытательный институт медицинской техники Хирургический сшивающий аппарат
US4098210A (en) 1977-02-18 1978-07-04 Wright V Gene Canvasworking method and article
US4075962A (en) 1977-03-02 1978-02-28 Mabry Patricia D Needlework technique using ribbon
US4300424A (en) 1977-03-14 1981-11-17 American Greetings Corporation Candle manufacturing system including wick cutting means
US4137921A (en) 1977-06-24 1979-02-06 Ethicon, Inc. Addition copolymers of lactide and glycolide and method of preparation
US4204542A (en) 1977-08-03 1980-05-27 Carbomedics, Inc. Multistrand carbon coated sutures
US4311002A (en) 1977-09-22 1982-01-19 Kabel Metallwerke Ghh Forming stranded stock
JPS6042301B2 (ja) 1978-02-27 1985-09-21 ユニチカ株式会社 太繊度合成繊維フイラメントの延伸方法
CA1107989A (en) 1978-05-16 1981-09-01 Alexandre Wolosianski Apparatus for screw-threading
US5147382A (en) 1978-12-08 1992-09-15 Ethicon, Inc. Elastomeric surgical sutures comprising segmented copolyether/esters
US4259959A (en) 1978-12-20 1981-04-07 Walker Wesley W Suturing element
ATE3447T1 (de) 1979-08-08 1983-06-15 Gebrueder Sulzer Aktiengesellschaft Duesenanordnung fuer eine webmaschine mit strahleintrag.
US4313448A (en) 1980-01-28 1982-02-02 Medtronic, Inc. Myocardial sutureless lead
US4317451A (en) 1980-02-19 1982-03-02 Ethicon, Inc. Plastic surgical staple
US4428376A (en) 1980-05-02 1984-01-31 Ethicon Inc. Plastic surgical staple
US4505274A (en) 1980-10-17 1985-03-19 Propper Manufacturing Co., Inc. Suture clip
US4372293A (en) 1980-12-24 1983-02-08 Vijil Rosales Cesar A Apparatus and method for surgical correction of ptotic breasts
SU982676A1 (ru) 1981-04-07 1982-12-23 Всесоюзный научно-исследовательский и испытательный институт медицинской техники Хирургическа скобка
DE3214479C2 (de) 1981-07-22 1986-05-15 Siemens AG, 1000 Berlin und 8000 München Handgerät zum Abschälen der äußeren Mantelschicht elektrischer Leitungen und elektrischer Kabel
US4490326A (en) 1981-07-30 1984-12-25 Ethicon, Inc. Molding process for polydioxanone polymers
FR2520390B1 (xx) 1982-01-26 1984-05-25 Asa Sa
US4454875A (en) 1982-04-15 1984-06-19 Techmedica, Inc. Osteal medical staple
US4741330A (en) 1983-05-19 1988-05-03 Hayhurst John O Method and apparatus for anchoring and manipulating cartilage
US6656182B1 (en) 1982-05-20 2003-12-02 John O. Hayhurst Tissue manipulation
US5417691A (en) 1982-05-20 1995-05-23 Hayhurst; John O. Apparatus and method for manipulating and anchoring tissue
US5601557A (en) 1982-05-20 1997-02-11 Hayhurst; John O. Anchoring and manipulating tissue
US4430998A (en) 1982-06-01 1984-02-14 Thoratec Laboratories Corporation Wound closing device
DE3227984C2 (de) 1982-07-27 1985-10-17 Abdoll-Hossein Dr. med. 4330 Mülheim Towfigh Vorrichtung zur Herstellung einer Sehnen-Stoßnaht
US4467805A (en) 1982-08-25 1984-08-28 Mamoru Fukuda Skin closure stapling device for surgical procedures
US4553544A (en) 1982-09-20 1985-11-19 Janome Sewing Machine Co. Ltd. Suturing instrument for surgical operation
US4493323A (en) 1982-12-13 1985-01-15 University Of Iowa Research Foundation Suturing device and method for using same
US4676245A (en) 1983-02-09 1987-06-30 Mamoru Fukuda Interlocking surgical staple assembly
US4535772A (en) 1983-03-10 1985-08-20 Kells Medical, Incorporated Skin closure device
US4595007A (en) 1983-03-14 1986-06-17 Ethicon, Inc. Split ring type tissue fastener
US4510934A (en) 1983-05-13 1985-04-16 Batra Subhash K Suture
US4531522A (en) 1983-06-20 1985-07-30 Ethicon, Inc. Two-piece tissue fastener with locking top and method for applying same
US4548202A (en) 1983-06-20 1985-10-22 Ethicon, Inc. Mesh tissue fasteners
US4532926A (en) 1983-06-20 1985-08-06 Ethicon, Inc. Two-piece tissue fastener with ratchet leg staple and sealable latching receiver
IL74460A (en) 1983-09-02 1990-01-18 Istec Ind & Technologies Ltd Surgical implement particularly useful for suturing prosthetic valves
US5104399A (en) 1986-12-10 1992-04-14 Endovascular Technologies, Inc. Artificial graft and implantation method
US7166125B1 (en) 1988-03-09 2007-01-23 Endovascular Technologies, Inc. Intraluminal grafting system
US4873976A (en) 1984-02-28 1989-10-17 Schreiber Saul N Surgical fasteners and method
US4635637A (en) 1984-03-29 1987-01-13 Schreiber Saul N Surgical suture
US4653486A (en) 1984-04-12 1987-03-31 Coker Tom P Fastener, particularly suited for orthopedic use
JPS61502379A (ja) 1984-06-14 1986-10-23 バイオリサ−チ　インコ−ポレイテツド 複合外科用縫合糸
US4689882A (en) 1984-10-22 1987-09-01 United Technologies Automotive, Inc. Hand tool and method for removing insulation from wire-wound ignition cable
US4610251A (en) 1985-04-19 1986-09-09 Kumar Sarbjeet S Surgical staple
US4712553A (en) 1985-05-30 1987-12-15 Cordis Corporation Sutures having a porous surface
US4637380A (en) 1985-06-24 1987-01-20 Orejola Wilmo C Surgical wound closures
US4669473A (en) 1985-09-06 1987-06-02 Acufex Microsurgical, Inc. Surgical fastener
US4610250A (en) 1985-10-08 1986-09-09 United States Surgical Corporation Two-part surgical fastener for fascia wound approximation
US4733665C2 (en) 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US4750910A (en) 1986-01-22 1988-06-14 Mitsui Toatsu Chemicals, Incorporated Indigo blue-colored bioabsorbable surgical fibers and production process thereof
US4884572A (en) 1986-05-20 1989-12-05 Concept, Inc. Tack and applicator for treating torn bodily material in vivo
US4895148A (en) 1986-05-20 1990-01-23 Concept, Inc. Method of joining torn parts of bodily tissue in vivo with a biodegradable tack member
US4841960A (en) 1987-02-10 1989-06-27 Garner Eric T Method and apparatus for interosseous bone fixation
US4719917A (en) 1987-02-17 1988-01-19 Minnesota Mining And Manufacturing Company Surgical staple
AU606383B2 (en) 1987-03-06 1991-02-07 Research Triangle Institute Polymer blends for selective biodegradability
US4865026A (en) 1987-04-23 1989-09-12 Barrett David M Sealing wound closure device
US5437680A (en) 1987-05-14 1995-08-01 Yoon; Inbae Suturing method, apparatus and system for use in endoscopic procedures
US5478353A (en) 1987-05-14 1995-12-26 Yoon; Inbae Suture tie device system and method for suturing anatomical tissue proximate an opening
US4898156A (en) 1987-05-18 1990-02-06 Mitek Surgical Products, Inc. Suture anchor
JPS63288146A (ja) 1987-05-20 1988-11-25 Nippon Medical Supply Corp 縫合糸包装用台紙
US4832025A (en) 1987-07-30 1989-05-23 American Cyanamid Company Thermoplastic surgical suture with a melt fused length
FR2619129B1 (fr) 1987-08-07 1990-02-09 Mas Richard Aiguillee de fil a coudre
WO1989001841A1 (en) 1987-08-28 1989-03-09 Tsentralnoe Konstruktorskoe Bjuro Unikalnogo Pribo Method and device for laser processing of an object
FR2620633B1 (fr) 1987-09-23 1991-09-20 Lyonnaise Eaux Procede et dispositif pour la realisation d'un faisceau de filaments, notamment de fibres creuses semi-permeables
JPH01113091A (ja) 1987-10-27 1989-05-01 Agency Of Ind Science & Technol モノフィラメントフィーダ
ATE95399T1 (de) 1987-10-30 1993-10-15 Howmedica Vorrichtung zum wiederherstellen einer sehne oder eines bandes.
US4887601A (en) 1987-11-06 1989-12-19 Ophthalmic Ventures Limited Partnership Adjustable surgical staple and method of using the same
US4899743A (en) 1987-12-15 1990-02-13 Mitek Surgical Products, Inc. Suture anchor installation tool
US4968315A (en) 1987-12-15 1990-11-06 Mitek Surgical Products, Inc. Suture anchor and suture anchor installation tool
JP2561853B2 (ja) 1988-01-28 1996-12-11 株式会社ジェイ・エム・エス 形状記憶性を有する成形体及びその使用方法
US4930945A (en) 1988-05-20 1990-06-05 Mitsubishi Metal Corporation Insert rotary cutter
US5002562A (en) 1988-06-03 1991-03-26 Oberlander Michael A Surgical clip
US4900605A (en) 1988-09-16 1990-02-13 Harold Thorgersen Bristle pile textile for garment applications
US5112344A (en) 1988-10-04 1992-05-12 Petros Peter E Surgical instrument and method of utilization of such
US5047047A (en) 1988-10-26 1991-09-10 Inbae Yoon Wound closing device
US4905367A (en) 1988-11-08 1990-03-06 Corvita Corporation Manufacture of stretchable porous sutures
US5217494A (en) 1989-01-12 1993-06-08 Coggins Peter R Tissue supporting prosthesis
US4997439A (en) 1989-01-26 1991-03-05 Chen Fusen H Surgical closure or anastomotic device
US4994073A (en) 1989-02-22 1991-02-19 United States Surgical Corp. Skin fastener
US5053047A (en) 1989-05-16 1991-10-01 Inbae Yoon Suture devices particularly useful in endoscopic surgery and methods of suturing
US4932962A (en) 1989-05-16 1990-06-12 Inbae Yoon Suture devices particularly useful in endoscopic surgery and methods of suturing
US4981149A (en) 1989-05-16 1991-01-01 Inbae Yoon Method for suturing with a bioabsorbable needle
US5222976A (en) 1989-05-16 1993-06-29 Inbae Yoon Suture devices particularly useful in endoscopic surgery
US5002550A (en) 1989-06-06 1991-03-26 Mitek Surgical Products, Inc. Suture anchor installation tool
US4946468A (en) 1989-06-06 1990-08-07 Mitek Surgical Products, Inc. Suture anchor and suture anchor installation tool
US4994084A (en) 1989-06-23 1991-02-19 Brennan H George Reconstructive surgery method and implant
JPH0380868A (ja) 1989-08-23 1991-04-05 Descente Ltd 薬剤徐放性縫合糸
DE3928677C2 (de) 1989-08-30 1998-05-14 Kimberly Clark Gmbh Tampon für medizinische oder hygienische Zwecke sowie Verfahren zu seiner Herstellung
US5451461A (en) 1989-09-01 1995-09-19 Ethicon, Inc. Thermal treatment of thermoplastic filaments for the preparation of surgical sutures
US5129906A (en) 1989-09-08 1992-07-14 Linvatec Corporation Bioabsorbable tack for joining bodily tissue and in vivo method and apparatus for deploying same
US5089010A (en) 1989-09-27 1992-02-18 United States Surgical Corporation Surgical needle-suture attachment possessing weakened suture segment for controlled suture release
US5156615A (en) 1989-09-27 1992-10-20 United States Surgical Corporation Surgical needle-suture attachment for controlled suture release
US5123911A (en) 1989-09-27 1992-06-23 United States Surgical Corporation Method for attaching a surgical needle to a suture
US5133738A (en) 1989-09-27 1992-07-28 United States Surgical Corporation Combined surgical needle-spiroid braided suture device
US5084063A (en) 1989-09-27 1992-01-28 United States Surgical Corporation Surgical needle-suture attachment
CA2026200A1 (en) 1989-09-27 1991-03-28 Herbert W. Korthoff Combined surgical needle-suture device and method for its manufacture
US5102418A (en) 1989-09-27 1992-04-07 United States Surgical Corporation Method for attaching a surgical needle to a suture
US5026390A (en) 1989-10-26 1991-06-25 Brown Alan W Surgical staple
US5007921A (en) 1989-10-26 1991-04-16 Brown Alan W Surgical staple
US5007922A (en) 1989-11-13 1991-04-16 Ethicon, Inc. Method of making a surgical suture
US5156788A (en) 1989-11-14 1992-10-20 United States Surgical Corporation Method and apparatus for heat tipping sutures
US4950285A (en) 1989-11-27 1990-08-21 Wilk Peter J Suture device
US5123913A (en) 1989-11-27 1992-06-23 Wilk Peter J Suture device
WO1993007813A1 (en) 1989-12-04 1993-04-29 Kensey Nash Corporation Plug device for sealing openings and method of use
US5037433A (en) 1990-05-17 1991-08-06 Wilk Peter J Endoscopic suturing device and related method and suture
US5197597A (en) 1990-06-05 1993-03-30 United States Surgical Corporation Suture retainer
US5102421A (en) 1990-06-14 1992-04-07 Wm. E. Anpach, III Suture anchor and method of forming
US6203565B1 (en) 1990-06-28 2001-03-20 Peter M. Bonutti Surgical devices assembled using heat bondable materials
SU1752358A1 (ru) 1990-06-29 1992-08-07 Крымский Медицинский Институт Хирургический шовный материал
US5269809A (en) 1990-07-02 1993-12-14 American Cyanamid Company Locking mechanism for use with a slotted suture anchor
US5041129A (en) 1990-07-02 1991-08-20 Acufex Microsurgical, Inc. Slotted suture anchor and method of anchoring a suture
US5037422A (en) 1990-07-02 1991-08-06 Acufex Microsurgical, Inc. Bone anchor and method of anchoring a suture to a bone
US5224946A (en) 1990-07-02 1993-07-06 American Cyanamid Company Bone anchor and method of anchoring a suture to a bone
SU1745214A1 (ru) 1990-07-04 1992-07-07 Межотраслевой научно-технический комплекс "Микрохирургия глаза" Головка автомата дл наложени хирургического ниточного шва
US5342395A (en) 1990-07-06 1994-08-30 American Cyanamid Co. Absorbable surgical repair devices
JP2890063B2 (ja) 1990-08-09 1999-05-10 グンゼ株式会社 手術用縫合糸の製造法
US5127413A (en) 1990-08-09 1992-07-07 Ebert Edward A Sinous suture
CA2048464A1 (en) 1990-08-17 1992-02-18 Michael P. Chesterfield Apparatus and method for producing braided suture products
US5306288A (en) 1990-09-05 1994-04-26 United States Surgical Corporation Combined surgical needle-suture device
CA2049123C (en) 1990-09-13 2002-01-15 David T. Green Apparatus and method for subcuticular stapling of body tissue
US5372146A (en) 1990-11-06 1994-12-13 Branch; Thomas P. Method and apparatus for re-approximating tissue
US5123910A (en) 1990-11-07 1992-06-23 Mcintosh Charles L Blunt tip surgical needle
CA2704219C (en) 1990-12-13 2011-01-04 United States Surgical Corporation Method and apparatus for tipping sutures
US5259846A (en) 1991-01-07 1993-11-09 United States Surgical Corporation Loop threaded combined surgical needle-suture device
US5320629B1 (en) 1991-01-07 2000-05-02 Advanced Surgical Inc Device and method for applying suture
US5234006A (en) 1991-01-18 1993-08-10 Eaton Alexander M Adjustable sutures and method of using the same
US5312456A (en) 1991-01-31 1994-05-17 Carnegie Mellon University Micromechanical barb and method for making the same
JP3124564B2 (ja) 1991-02-21 2001-01-15 マニー株式会社 医療用縫合針及びその製造方法
US5480403A (en) 1991-03-22 1996-01-02 United States Surgical Corporation Suture anchoring device and method
US5354298A (en) 1991-03-22 1994-10-11 United States Surgical Corporation Suture anchor installation system
US5192274A (en) 1991-05-08 1993-03-09 Bierman Steven F Anchor pad for catheterization system
US5269783A (en) 1991-05-13 1993-12-14 United States Surgical Corporation Device and method for repairing torn tissue
DE4115836C2 (de) 1991-05-15 1999-11-25 Jordan Reflektoren Gmbh & Co Leuchte mit einer Reflektoranordnung und einem Abblendkörper
SE9101752D0 (sv) 1991-06-10 1991-06-10 Procordia Ortech Ab Method of producing a microstructure in a bioresorbable element
BE1005173A3 (nl) * 1991-08-13 1993-05-11 Picanol Nv Draadrem.
US5179964A (en) 1991-08-30 1993-01-19 Cook Melvin S Surgical stapling method
US5263973A (en) 1991-08-30 1993-11-23 Cook Melvin S Surgical stapling method
US5207679A (en) 1991-09-26 1993-05-04 Mitek Surgical Products, Inc. Suture anchor and installation tool
US5141520A (en) 1991-10-29 1992-08-25 Marlowe Goble E Harpoon suture anchor
DE4136266A1 (de) 1991-11-04 1993-05-06 Kabelmetal Electro Gmbh Vorrichtung zum verseilen von strangfoermigem gut insbesondere groesseren querschnittes mit wechselnder schlagrichtung
US5123919A (en) 1991-11-21 1992-06-23 Carbomedics, Inc. Combined prosthetic aortic heart valve and vascular graft
US5176692A (en) 1991-12-09 1993-01-05 Wilk Peter J Method and surgical instrument for repairing hernia
US5765560A (en) 1991-12-16 1998-06-16 Adeva Medical, Gesellschaft Fur Entwicklung Und Vertrieb Von Medizinischen, Implantat-Artikeln Mbh Trachostoma valve and tissue connector and housing for use as a part thereof
US5217486A (en) 1992-02-18 1993-06-08 Mitek Surgical Products, Inc. Suture anchor and installation tool
US5352515A (en) 1992-03-02 1994-10-04 American Cyanamid Company Coating for tissue drag reduction
US5225485A (en) 1992-03-03 1993-07-06 United States Surgical Corporation Polyetherimide ester suture and its method of manufacture and method of use
US5272005A (en) 1992-03-25 1993-12-21 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Sheath/core composite materials
CA2090371A1 (en) 1992-03-27 1993-09-28 William Frank Banholzer Water jet mixing tubes used in water jet cutting devices and method of preparation thereof
FR2690840B1 (fr) 1992-05-07 1994-08-19 Patrick Frechet Dispositif d'extension de tissu vivant.
US5484451A (en) 1992-05-08 1996-01-16 Ethicon, Inc. Endoscopic surgical instrument and staples for applying purse string sutures
US5242457A (en) 1992-05-08 1993-09-07 Ethicon, Inc. Surgical instrument and staples for applying purse string sutures
US5766246A (en) 1992-05-20 1998-06-16 C. R. Bard, Inc. Implantable prosthesis and method and apparatus for loading and delivering an implantable prothesis
FR2693108B3 (fr) 1992-06-10 1994-08-12 Hexabio Matériau chirurgical résorbable en particulier fil de suture résorbable.
US5366756A (en) 1992-06-15 1994-11-22 United States Surgical Corporation Method for treating bioabsorbable implant material
CA2094111C (en) 1992-06-15 1999-02-16 Daniel R. Lee Suture anchoring device and method
US5207694A (en) 1992-06-18 1993-05-04 Surgical Invent Ab Method for performing a surgical occlusion, and kit and applicator for carrying out the method
FR2692774B1 (fr) 1992-06-25 1999-05-21 Bfl Medical Sarl Materiel utilisable pour la reparation du tendon d'achille rompu.
US5312422A (en) 1992-07-16 1994-05-17 Linvatec Corporation Endoscopic suturing needle
US5540704A (en) 1992-09-04 1996-07-30 Laurus Medical Corporation Endoscopic suture system
US5387227A (en) 1992-09-10 1995-02-07 Grice; O. Drew Method for use of a laparo-suture needle
CA2437777C (en) 1992-09-21 2006-11-28 United States Surgical Corporation Device for applying a meniscal staple
CN1091315A (zh) 1992-10-08 1994-08-31 E·R·斯奎布父子公司 血纤维蛋白封闭剂组合物及其使用方法
US5282832A (en) 1992-10-09 1994-02-01 United States Surgical Corporation Suture clip
US5222508A (en) 1992-10-09 1993-06-29 Osvaldo Contarini Method for suturing punctures of the human body
DE4304353A1 (de) 1992-10-24 1994-04-28 Helmut Dipl Ing Wurster Endoskopisches Nähgerät
IL103737A (en) 1992-11-13 1997-02-18 Technion Res & Dev Foundation Stapler device particularly useful in medical suturing
US5649939A (en) 1992-12-08 1997-07-22 Reddick; Eddie J. Laparoscopic suture introducer
US5417699A (en) 1992-12-10 1995-05-23 Perclose Incorporated Device and method for the percutaneous suturing of a vascular puncture site
US20020095164A1 (en) 1997-06-26 2002-07-18 Andreas Bernard H. Device and method for suturing tissue
US5403346A (en) 1992-12-31 1995-04-04 Loeser; Edward A. Self-affixing suture assembly
US6387363B1 (en) 1992-12-31 2002-05-14 United States Surgical Corporation Biocompatible medical devices
US5632753A (en) 1992-12-31 1997-05-27 Loeser; Edward A. Surgical procedures
DE4302895C2 (de) 1993-02-02 1996-03-28 Wiessner Serag Gmbh & Co Kg Chirurgischer Faden
US5306290A (en) 1993-02-12 1994-04-26 Mitek Surgical Products, Inc. Suture button
US5380334A (en) 1993-02-17 1995-01-10 Smith & Nephew Dyonics, Inc. Soft tissue anchors and systems for implantation
US5341922A (en) 1993-02-24 1994-08-30 Ethicon, Inc. Peelable foil suture packaging
US5330488A (en) 1993-03-23 1994-07-19 Goldrath Milton H Verres needle suturing kit
US5350385A (en) 1993-04-28 1994-09-27 Christy William J Surgical stab wound closure device and method
US5342376A (en) 1993-05-03 1994-08-30 Dermagraphics, Inc. Inserting device for a barbed tissue connector
US6241747B1 (en) 1993-05-03 2001-06-05 Quill Medical, Inc. Barbed Bodily tissue connector
US8795332B2 (en) 2002-09-30 2014-08-05 Ethicon, Inc. Barbed sutures
EP0627474B1 (en) 1993-05-13 2000-10-25 American Cyanamid Company Aqueous silicone coating compositions
US5464426A (en) 1993-05-14 1995-11-07 Bonutti; Peter M. Method of closing discontinuity in tissue
WO1995001129A1 (en) 1993-07-01 1995-01-12 W.L. Gore & Associates, Inc. A suture needle
US5500000A (en) 1993-07-01 1996-03-19 United States Surgical Corporation Soft tissue repair system and method
US5354271A (en) 1993-08-05 1994-10-11 Voda Jan K Vascular sheath
US5462561A (en) 1993-08-05 1995-10-31 Voda; Jan K. Suture device
US5899911A (en) 1993-08-25 1999-05-04 Inlet Medical, Inc. Method of using needle-point suture passer to retract and reinforce ligaments
US5450860A (en) 1993-08-31 1995-09-19 W. L. Gore & Associates, Inc. Device for tissue repair and method for employing same
US5540718A (en) 1993-09-20 1996-07-30 Bartlett; Edwin C. Apparatus and method for anchoring sutures
US5425747A (en) 1993-10-12 1995-06-20 Brotz; Gregory R. Suture
US5584859A (en) 1993-10-12 1996-12-17 Brotz; Gregory R. Suture assembly
CA2117967A1 (en) 1993-10-27 1995-04-28 Thomas W. Sander Tissue repair device and apparatus and method for fabricating same
US5545180A (en) 1993-12-13 1996-08-13 Ethicon, Inc. Umbrella-shaped suture anchor device with actuating ring member
US5527342A (en) 1993-12-14 1996-06-18 Pietrzak; William S. Method and apparatus for securing soft tissues, tendons and ligaments to bone
US5487216A (en) 1994-01-13 1996-01-30 Ethicon, Inc. Control system for an automatic needle-suture assembly and packaging machine
US5728122A (en) 1994-01-18 1998-03-17 Datascope Investment Corp. Guide wire with releaseable barb anchor
US5571216A (en) 1994-01-19 1996-11-05 The General Hospital Corporation Methods and apparatus for joining collagen-containing materials
US5662714A (en) 1994-01-21 1997-09-02 M.X.M. Device for extending living tissues
US6315788B1 (en) 1994-02-10 2001-11-13 United States Surgical Corporation Composite materials and surgical articles made therefrom
US5626611A (en) 1994-02-10 1997-05-06 United States Surgical Corporation Composite bioabsorbable materials and surgical articles made therefrom
US5391173A (en) 1994-02-10 1995-02-21 Wilk; Peter J. Laparoscopic suturing technique and associated device
GB9404268D0 (en) 1994-03-05 1994-04-20 Univ Nottingham Surface treatment of shape memory alloys
US5486197A (en) 1994-03-24 1996-01-23 Ethicon, Inc. Two-piece suture anchor with barbs
US5411523A (en) 1994-04-11 1995-05-02 Mitek Surgical Products, Inc. Suture anchor and driver combination
DK0952792T3 (da) 1994-06-06 2003-12-08 Osiris Therapeutics Inc Biomatrix til vævsregeneration
US5593424A (en) 1994-08-10 1997-01-14 Segmed, Inc. Apparatus and method for reducing and stabilizing the circumference of a vascular structure
US5549633A (en) 1994-08-24 1996-08-27 Kensey Nash Corporation Apparatus and methods of use for preventing blood seepage at a percutaneous puncture site
US5472452A (en) 1994-08-30 1995-12-05 Linvatec Corporation Rectilinear anchor for soft tissue fixation
US5562685A (en) 1994-09-16 1996-10-08 General Surgical Innovations, Inc. Surgical instrument for placing suture or fasteners
US6206908B1 (en) 1994-09-16 2001-03-27 United States Surgical Corporation Absorbable polymer and surgical articles fabricated therefrom
US5522845A (en) 1994-09-27 1996-06-04 Mitek Surgical Products, Inc. Bone anchor and bone anchor installation
US5464427A (en) 1994-10-04 1995-11-07 Synthes (U.S.A.) Expanding suture anchor
ATE175560T1 (de) 1994-10-06 1999-01-15 Theratechnologies Inc Nahtloser wundverschluss mit hilfe einer verschnürung von auf der haut befestigten pflasterelementen
US5807406A (en) 1994-10-07 1998-09-15 Baxter International Inc. Porous microfabricated polymer membrane structures
US5938668A (en) 1994-10-07 1999-08-17 United States Surgical Surgical suturing apparatus
DE4440095A1 (de) 1994-11-10 1996-05-15 Braun B Surgical Gmbh Chirurgisches Nahtmaterial, seine Verwendung in der Chirurgie und Verfahren zu seiner Herstellung
US5716358A (en) 1994-12-02 1998-02-10 Johnson & Johnson Professional, Inc. Directional bone fixation device
US5643295A (en) 1994-12-29 1997-07-01 Yoon; Inbae Methods and apparatus for suturing tissue
US5653716A (en) 1994-12-29 1997-08-05 Acufex Microsurgical, Inc. Suture manipulating instrument with grasping members
US5665109A (en) 1994-12-29 1997-09-09 Yoon; Inbae Methods and apparatus for suturing tissue
US5968076A (en) 1995-03-03 1999-10-19 United States Surgical Corporation Channel-bodied surgical needle and method of manufacture
US5531760A (en) 1995-04-14 1996-07-02 Alwafaie; Mohammed G. Skin closure clip
US5540705A (en) 1995-05-19 1996-07-30 Suturtek, Inc. Suturing instrument with thread management
US5571139A (en) 1995-05-19 1996-11-05 Jenkins, Jr.; Joseph R. Bidirectional suture anchor
AU712207B2 (en) 1995-06-06 1999-10-28 Raymond Thal Knotless suture anchor assembly
US5571175A (en) 1995-06-07 1996-11-05 St. Jude Medical, Inc. Suture guard for prosthetic heart valve
US5722991A (en) 1995-06-07 1998-03-03 United States Surgical Corporation Apparatus and method for attaching surgical needle suture components
US6814748B1 (en) 1995-06-07 2004-11-09 Endovascular Technologies, Inc. Intraluminal grafting system
US6129741A (en) 1995-06-10 2000-10-10 Forschungszentrum Karlsruhe Gmbh Surgical suturing needle
JP2000500029A (ja) 1995-06-14 2000-01-11 メドワークス・コーポレーション 腹腔鏡による尿道固定術を施すための外科手術用キット及び手術方法並びに尿道固定術において使用される装置
US5662654A (en) 1995-06-14 1997-09-02 Incont, Inc. Bone anchor, insertion tool and surgical kit employing same
US5643288A (en) 1995-06-14 1997-07-01 Incont, Inc. Apparatus and method for laparoscopic urethropexy
US5997554A (en) 1995-06-14 1999-12-07 Medworks Corporation Surgical template and surgical method employing same
US6042583A (en) 1995-06-14 2000-03-28 Medworks Corporation Bone anchor-insertion tool and surgical method employing same
US5744151A (en) 1995-06-30 1998-04-28 Capelli; Christopher C. Silver-based pharmaceutical compositions
US6102947A (en) 1995-07-20 2000-08-15 Gordon; Leonard Splint with flexible body for repair of tendons or ligaments and method
US5723008A (en) 1995-07-20 1998-03-03 Gordon; Leonard Splint for repair of tendons or ligaments and method
US5669935A (en) 1995-07-28 1997-09-23 Ethicon, Inc. One-way suture retaining device for braided sutures
JPH0990421A (ja) 1995-09-27 1997-04-04 Sharp Corp 液晶表示装置およびその製造方法
DE19536070C2 (de) * 1995-09-28 2000-12-07 Krantz Textiltechnik Gmbh Düse zum Transport eines Stranges und Vorrichtung zum Behandeln von Textilgut in Form mindestens eines endlosen Stranges
JPH09103477A (ja) 1995-10-12 1997-04-22 Unitika Ltd 縫合糸
US6509098B1 (en) 1995-11-17 2003-01-21 Massachusetts Institute Of Technology Poly(ethylene oxide) coated surfaces
US5645568A (en) 1995-11-20 1997-07-08 Medicinelodge, Inc. Expandable body suture
USD387161S (en) 1996-01-02 1997-12-02 Acufex Microsurgical, Inc. Surgical suture knot pusher with hooks
USD386583S (en) 1996-01-02 1997-11-18 Acufex Microsurgical, Inc. Proximal end of a surgical suture slotted knot pusher
US5810853A (en) 1996-01-16 1998-09-22 Yoon; Inbae Knotting element for use in suturing anatomical tissue and methods therefor
US5702462A (en) 1996-01-24 1997-12-30 Oberlander; Michael Method of meniscal repair
JP3659525B2 (ja) 1996-02-16 2005-06-15 アルフレッサファーマ株式会社 針付縫合糸の製造装置
JP3327765B2 (ja) 1996-02-16 2002-09-24 株式会社アズウェル 針付縫合糸の製造装置
US5702397A (en) 1996-02-20 1997-12-30 Medicinelodge, Inc. Ligament bone anchor and method for its use
FI107124B (fi) 1996-03-01 2001-06-15 Rolf E A Nordstroem Kirurginen ommellanka
RU2139690C1 (ru) 1996-03-25 1999-10-20 Плетиков Сергей Михайлович Способ наложения сухожильного шва
US6149660A (en) 1996-04-22 2000-11-21 Vnus Medical Technologies, Inc. Method and apparatus for delivery of an appliance in a vessel
US6491714B1 (en) 1996-05-03 2002-12-10 William F. Bennett Surgical tissue repair and attachment apparatus and method
DE19618891C1 (de) 1996-05-10 1997-04-03 Barbara Bloch Verfahren zum Herstellen eines Mähfadens sowie Mähfaden aus einem verstreckten und extrudierten Kunststoff
US5893856A (en) 1996-06-12 1999-04-13 Mitek Surgical Products, Inc. Apparatus and method for binding a first layer of material to a second layer of material
US6063105A (en) 1996-06-18 2000-05-16 United States Surgical Medical devices fabricated from elastomeric alpha-olefins
US5843178A (en) 1996-06-20 1998-12-01 St. Jude Medical, Inc. Suture guard for annuloplasty ring
US5716376A (en) 1996-06-28 1998-02-10 United States Surgical Corporation Absorbable mixture and coatings for surgical articles fabricated therefrom
US6117162A (en) 1996-08-05 2000-09-12 Arthrex, Inc. Corkscrew suture anchor
US5683417A (en) 1996-08-14 1997-11-04 Cooper; William I. Suture and method for endoscopic surgery
US5919234A (en) 1996-08-19 1999-07-06 Macropore, Inc. Resorbable, macro-porous, non-collapsing and flexible membrane barrier for skeletal repair and regeneration
US6984241B2 (en) 1996-09-13 2006-01-10 Tendon Technology, Ltd. Apparatus and methods for tendon or ligament repair
US6083244A (en) 1996-09-13 2000-07-04 Tendon Technology, Ltd. Apparatus and method for tendon or ligament repair
US7611521B2 (en) 1996-09-13 2009-11-03 Tendon Technology, Ltd. Apparatus and methods for tendon or ligament repair
JPH1085225A (ja) 1996-09-18 1998-04-07 Yuichi Matsuzawa 先細り糸付手術用縫合針
CA2217406C (en) 1996-10-04 2006-05-30 United States Surgical Corporation Suture anchor installation system with disposable loading unit
US5897572A (en) 1996-10-11 1999-04-27 Cornell Research Foundation, Inc. Microsurgical suture needle
US5891166A (en) 1996-10-30 1999-04-06 Ethicon, Inc. Surgical suture having an ultrasonically formed tip, and apparatus and method for making same
US5817129A (en) 1996-10-31 1998-10-06 Ethicon, Inc. Process and apparatus for coating surgical sutures
US6331181B1 (en) 1998-12-08 2001-12-18 Intuitive Surgical, Inc. Surgical robotic tools, data architecture, and use
FR2757371B1 (fr) 1996-12-20 1999-03-26 Mxm Dispositif elastique a grande capacite d'allongement pour l'extension de tissu vivant
US5972024A (en) 1996-12-24 1999-10-26 Metacardia, Inc. Suture-staple apparatus and method
US6074419A (en) 1996-12-31 2000-06-13 St. Jude Medical, Inc. Indicia for prosthetic device
US5843087A (en) 1997-01-30 1998-12-01 Ethicon, Inc. Suture anchor installation tool
US6012216A (en) 1997-04-30 2000-01-11 Ethicon, Inc. Stand alone swage apparatus
US5782864A (en) 1997-04-03 1998-07-21 Mitek Surgical Products, Inc. Knotless suture system and method
US6867248B1 (en) 1997-05-12 2005-03-15 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
US5814051A (en) 1997-06-06 1998-09-29 Mitex Surgical Products, Inc. Suture anchor insertion system
JPH1113091A (ja) 1997-06-23 1999-01-19 Hitachi Constr Mach Co Ltd 建設機械の油圧駆動装置
US6071292A (en) 1997-06-28 2000-06-06 Transvascular, Inc. Transluminal methods and devices for closing, forming attachments to, and/or forming anastomotic junctions in, luminal anatomical structures
US5916224A (en) 1997-07-09 1999-06-29 The United States Of America As Represented By The Secretary Of The Army Tendon repair clip implant
US5895395A (en) 1997-07-17 1999-04-20 Yeung; Teresa T. Partial to full thickness suture device & method for endoscopic surgeries
US6159234A (en) 1997-08-01 2000-12-12 Peter M. Bonutti Method and apparatus for securing a suture
US20050216059A1 (en) 2002-09-05 2005-09-29 Bonutti Peter M Method and apparatus for securing a suture
US6241771B1 (en) 1997-08-13 2001-06-05 Cambridge Scientific, Inc. Resorbable interbody spinal fusion devices
US5906617A (en) 1997-08-15 1999-05-25 Meislin; Robert J. Surgical repair with hook-and-loop fastener
IL121752A0 (en) 1997-09-11 1998-02-22 Gaber Benny Stitching tool
US5887594A (en) 1997-09-22 1999-03-30 Beth Israel Deaconess Medical Center Inc. Methods and devices for gastroesophageal reflux reduction
US5950633A (en) 1997-10-02 1999-09-14 Ethicon, Inc. Microsurgical technique for cosmetic surgery
US6027523A (en) 1997-10-06 2000-02-22 Arthrex, Inc. Suture anchor with attached disk
CA2346011C (en) 1997-10-10 2009-01-20 Drexel University Hybrid nanofibril matrices for use as tissue engineering devices
DE69834375T2 (de) 1997-10-10 2007-03-15 Ethicon, Inc. Geflochtenes Nahtmaterial mit verbesserter Knotenfestigkeit
US6409674B1 (en) 1998-09-24 2002-06-25 Data Sciences International, Inc. Implantable sensor with wireless communication
WO1999021488A1 (en) 1997-10-29 1999-05-06 Oh Nahm Gun Suture needle
US6056778A (en) 1997-10-29 2000-05-02 Arthrex, Inc. Meniscal repair device
US5964783A (en) 1997-11-07 1999-10-12 Arthrex, Inc. Suture anchor with insert-molded suture
US5954747A (en) 1997-11-20 1999-09-21 Clark; Ron Meniscus repair anchor system
US6015410A (en) 1997-12-23 2000-01-18 Bionx Implants Oy Bioabsorbable surgical implants for endoscopic soft tissue suspension procedure
US6001111A (en) 1998-01-16 1999-12-14 Cardiothoracic Systems, Inc. Low profile vessel occluder with and without detachable applicator
IL122994A (en) 1998-01-19 2001-12-23 Wisebands Ltd Suture tightening device for closing wounds and a method for its use
US6146406A (en) 1998-02-12 2000-11-14 Smith & Nephew, Inc. Bone anchor
US6160084A (en) 1998-02-23 2000-12-12 Massachusetts Institute Of Technology Biodegradable shape memory polymers
CA2316945A1 (en) 1998-02-23 1999-08-26 Mnemoscience Gmbh Shape memory polymers
US7297142B2 (en) 1998-02-24 2007-11-20 Hansen Medical, Inc. Interchangeable surgical instrument
US7214230B2 (en) 1998-02-24 2007-05-08 Hansen Medical, Inc. Flexible instrument
US6494898B1 (en) 1998-02-25 2002-12-17 United States Surgical Corporation Absorbable copolymers and surgical articles fabricated therefrom
AU3812099A (en) 1998-04-01 1999-10-18 Bionx Implants Oy Bioabsorbable surgical fastener for tissue treatment
US6024757A (en) 1998-04-14 2000-02-15 Ethicon, Inc. Method for cutting a surgical suture tip
US5964765A (en) 1998-04-16 1999-10-12 Axya Medical, Inc. Soft tissue fixation device
US6056751A (en) 1998-04-16 2000-05-02 Axya Medical, Inc. Sutureless soft tissue fixation assembly
US6106545A (en) 1998-04-16 2000-08-22 Axya Medical, Inc. Suture tensioning and fixation device
NL1009028C2 (nl) 1998-04-28 1999-10-29 Adri Marinus Blomme Hechtmiddelen voor het verbinden van een buisvormige vaatprothese met een bloedvat in het lichaam alsmede aftakkingsmiddelen, een vaatprothese, een inrichting voor het in het lichaam inbrengen en aanhechten van een vaatprothese en een vaatprothesesysteem.
JP3983888B2 (ja) 1998-05-07 2007-09-26 オリンパス株式会社 縫合具及び経内視鏡用縫合アッセンブリ
CA2333121C (en) 1998-05-21 2006-07-25 Christopher J. Walshe A tissue anchor system
JPH11332828A (ja) 1998-05-22 1999-12-07 Topcon Corp 眼科装置
US6974450B2 (en) 1999-12-30 2005-12-13 Pearl Technology Holdings, Llc Face-lifting device
FI981203A (fi) 1998-05-29 1999-11-30 Rolf E A Nordstroem Silikonielastomeeria olevan kirurgisen ommellangan ja neulan välinen liitos
US7452371B2 (en) 1999-06-02 2008-11-18 Cook Incorporated Implantable vascular device
AU754156B2 (en) 1998-06-02 2002-11-07 Cook Incorporated Multiple-sided intraluminal medical device
US6945980B2 (en) 1998-06-03 2005-09-20 Medtronic, Inc. Multiple loop tissue connector apparatus and methods
US6607541B1 (en) 1998-06-03 2003-08-19 Coalescent Surgical, Inc. Tissue connector apparatus and methods
US6613059B2 (en) 1999-03-01 2003-09-02 Coalescent Surgical, Inc. Tissue connector apparatus and methods
US6514265B2 (en) 1999-03-01 2003-02-04 Coalescent Surgical, Inc. Tissue connector apparatus with cable release
US6641593B1 (en) 1998-06-03 2003-11-04 Coalescent Surgical, Inc. Tissue connector apparatus and methods
JP2002518082A (ja) 1998-06-10 2002-06-25 コンバージ メディカル， インコーポレイテッド 縫合なし吻合システム
US6045561A (en) 1998-06-23 2000-04-04 Orthopaedic Biosystems Ltd., Inc. Surgical knot manipulator
US6174324B1 (en) 1998-07-13 2001-01-16 Axya Medical, Inc. Suture guide and fastener
DE19833703A1 (de) 1998-07-27 2000-02-03 Cetex Chemnitzer Textilmaschin Verfahren und Vorrichtung zum Aufwickeln von kontinuierlich angeliefertem Spulgut zu einer Präzisionskreuzspule
US6334865B1 (en) 1998-08-04 2002-01-01 Fusion Medical Technologies, Inc. Percutaneous tissue track closure assembly and method
US6214030B1 (en) 1998-08-10 2001-04-10 Mani, Inc. Suture needle
US6168633B1 (en) 1998-08-10 2001-01-02 Itzhak Shoher Composite surface composition for an implant structure
US6355066B1 (en) 1998-08-19 2002-03-12 Andrew C. Kim Anterior cruciate ligament reconstruction hamstring tendon fixation system
US6131785A (en) 1998-08-27 2000-10-17 E. I. Du Pont De Nemours And Company Air jet piddling
US6146407A (en) 1998-09-11 2000-11-14 Bio Innovation, Ltd. Suture anchor installation devices and methods
US6165203A (en) 1998-09-11 2000-12-26 Bio Innovation, Ltd. Suture anchor installation devices and methods
US6183499B1 (en) 1998-09-11 2001-02-06 Ethicon, Inc. Surgical filament construction
US6921811B2 (en) 1998-09-22 2005-07-26 Biosurface Engineering Technologies, Inc. Bioactive coating composition and methods
US6235869B1 (en) 1998-10-20 2001-05-22 United States Surgical Corporation Absorbable polymers and surgical articles fabricated therefrom
US7044134B2 (en) 1999-11-08 2006-05-16 Ev3 Sunnyvale, Inc Method of implanting a device in the left atrial appendage
US7387634B2 (en) 1998-11-23 2008-06-17 Benderev Theodore V System for securing sutures, grafts and soft tissue to bone and periosteum
US6110484A (en) 1998-11-24 2000-08-29 Cohesion Technologies, Inc. Collagen-polymer matrices with differential biodegradability
US7125403B2 (en) 1998-12-08 2006-10-24 Intuitive Surgical In vivo accessories for minimally invasive robotic surgery
US6522906B1 (en) 1998-12-08 2003-02-18 Intuitive Surgical, Inc. Devices and methods for presenting and regulating auxiliary information on an image display of a telesurgical system to assist an operator in performing a surgical procedure
US6395029B1 (en) 1999-01-19 2002-05-28 The Children's Hospital Of Philadelphia Sustained delivery of polyionic bioactive agents
US20070225764A1 (en) 1999-02-02 2007-09-27 Benavitz William C Insert molded suture anchor
US7211088B2 (en) 1999-02-02 2007-05-01 Arthrex, Inc. Bioabsorbable tissue tack with oval-shaped head and method of tissue fixation using the same
FR2789314B1 (fr) 1999-02-09 2001-04-27 Virsol Materiau de suture de plaies a base de methylidene malonate
US6656489B1 (en) 1999-02-10 2003-12-02 Isotis N.V. Scaffold for tissue engineering cartilage having outer surface layers of copolymer and ceramic material
US6319231B1 (en) 1999-02-12 2001-11-20 Abiomed, Inc. Medical connector
CA2364127A1 (en) 1999-03-01 2000-09-08 Ortho-Mcneil Pharmaceutical, Inc. Composition comprising a tramadol material and a selective cox-2 inhibitor drug
US8118822B2 (en) 1999-03-01 2012-02-21 Medtronic, Inc. Bridge clip tissue connector apparatus and methods
RU2139734C1 (ru) 1999-03-03 1999-10-20 Суламанидзе Марлен Андреевич Хирургическая нить для косметических операций
EP1867348B1 (en) 1999-03-25 2012-05-16 Metabolix, Inc. Medical devices and applications of polyhydroxyalkanoate polymers
US6554802B1 (en) 1999-03-31 2003-04-29 Medtronic, Inc. Medical catheter anchor
US6981983B1 (en) 1999-03-31 2006-01-03 Rosenblatt Peter L System and methods for soft tissue reconstruction
US6045571A (en) 1999-04-14 2000-04-04 Ethicon, Inc. Multifilament surgical cord
US6689153B1 (en) 1999-04-16 2004-02-10 Orthopaedic Biosystems Ltd, Inc. Methods and apparatus for a coated anchoring device and/or suture
GB9909301D0 (en) 1999-04-22 1999-06-16 Kci Medical Ltd Wound treatment apparatus employing reduced pressure
US6383201B1 (en) 1999-05-14 2002-05-07 Tennison S. Dong Surgical prosthesis for repairing a hernia
US7138441B1 (en) 1999-05-29 2006-11-21 United States Surgical Corporation Bioabsorbable blends and surgical articles therefrom
US6251143B1 (en) 1999-06-04 2001-06-26 Depuy Orthopaedics, Inc. Cartilage repair unit
DK1581162T3 (da) 1999-06-09 2011-08-01 Ethicon Inc Indretning til justering af polymerimplantater ved bløde overflader
US7160312B2 (en) 1999-06-25 2007-01-09 Usgi Medical, Inc. Implantable artificial partition and methods of use
US6991643B2 (en) 2000-12-20 2006-01-31 Usgi Medical Inc. Multi-barbed device for retaining tissue in apposition and methods of use
US6626899B2 (en) 1999-06-25 2003-09-30 Nidus Medical, Llc Apparatus and methods for treating tissue
WO2001006952A1 (en) 1999-07-16 2001-02-01 Med Institute, Inc. Stent adapted for tangle-free deployment
US6776340B2 (en) 1999-07-23 2004-08-17 Tri Star Technologies, A General Partnership Duplicate laser marking discrete consumable articles
US6610071B1 (en) 1999-07-26 2003-08-26 Beth Israel Deaconess Medical Center Suture system
JP4859317B2 (ja) 1999-08-06 2012-01-25 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 薬剤放出生分解性繊維インプラント
US7033603B2 (en) 1999-08-06 2006-04-25 Board Of Regents The University Of Texas Drug releasing biodegradable fiber for delivery of therapeutics
US6592609B1 (en) 1999-08-09 2003-07-15 Bonutti 2003 Trust-A Method and apparatus for securing tissue
US6554852B1 (en) 1999-08-25 2003-04-29 Michael A. Oberlander Multi-anchor suture
EP1078602A3 (en) 1999-08-26 2001-04-04 Mani, Inc. Suturing needle for medical use
JP2003508564A (ja) 1999-08-27 2003-03-04 コヒージョン テクノロジーズ， インコーポレイテッド 高強度の医療用シーラントとして使用するための相互侵入ポリマー網目構造を形成する組成物
EP1210014A1 (en) 1999-09-07 2002-06-05 Microvena Corporation Retrievable septal defect closure device
USD433753S (en) 1999-09-24 2000-11-14 Wisebands Ltd. Suture band tightening device for closing wounds
US6613254B1 (en) 1999-10-19 2003-09-02 Ethicon, Inc. Method for making extruded, oriented fiber
CH694268A5 (de) * 1999-10-20 2004-10-29 Mitsubishi Electric Corp Automatische Drahtzufuehrung fuer Funkenerosionsmaschinen.
US7004970B2 (en) 1999-10-20 2006-02-28 Anulex Technologies, Inc. Methods and devices for spinal disc annulus reconstruction and repair
US6592625B2 (en) 1999-10-20 2003-07-15 Anulex Technologies, Inc. Spinal disc annulus reconstruction method and spinal disc annulus stent
US7615076B2 (en) 1999-10-20 2009-11-10 Anulex Technologies, Inc. Method and apparatus for the treatment of the intervertebral disc annulus
US6626930B1 (en) 1999-10-21 2003-09-30 Edwards Lifesciences Corporation Minimally invasive mitral valve repair method and apparatus
US6231911B1 (en) 1999-10-29 2001-05-15 Clarence Steinback Ultra high speed hot dog incisor
US6641592B1 (en) 1999-11-19 2003-11-04 Lsi Solutions, Inc. System for wound closure
US6623492B1 (en) 2000-01-25 2003-09-23 Smith & Nephew, Inc. Tissue fastener
EP1251888A1 (en) 2000-02-03 2002-10-30 Nexia Biotechnologies, Inc. Surgical sutures containing spider silk
US6478809B1 (en) 2000-02-04 2002-11-12 Gregory R. Brotz Suture and method of use
US6270517B1 (en) 2000-02-04 2001-08-07 Gregory R. Brotz Suture assembly and method
US6264675B1 (en) 2000-02-04 2001-07-24 Gregory R. Brotz Single suture structure
US6296659B1 (en) 2000-02-29 2001-10-02 Opus Medical, Inc. Single-tailed suturing method and apparatus
US9138222B2 (en) 2000-03-13 2015-09-22 P Tech, Llc Method and device for securing body tissue
US6712830B2 (en) 2000-03-15 2004-03-30 Esplin Medical Inventions, L.L.C. Soft tissue anchor
DE10019604C2 (de) 2000-04-20 2002-06-27 Ethicon Gmbh Implantat
DE10021122C1 (de) 2000-04-29 2001-11-08 Aesculap Ag & Co Kg Faden-Anker-System zum Verbinden von Gewebeteilen und Instrument zum Einsetzen eines Ankerimplantats
US20050119694A1 (en) 2000-05-19 2005-06-02 Jacobs Daniel I. Remotely anchored tissue fixation device and method
US7510566B2 (en) 2000-05-19 2009-03-31 Coapt Systems, Inc. Multi-point tissue tension distribution device and method, a chin lift variation
US20040010275A1 (en) 2000-05-19 2004-01-15 Daniel Jacobs Multi-point tissue tension distribution device and method, a custom-fittable variation
US20040260340A1 (en) 2000-05-19 2004-12-23 Jacobs Daniel Irwin Remotely anchored tissue fixation device and method
US6645226B1 (en) 2000-05-19 2003-11-11 Coapt Systems, Inc. Multi-point tension distribution system device and method of tissue approximation using that device to improve wound healing
US7156862B2 (en) 2000-05-19 2007-01-02 Coapt Systems, Inc. Multi-point tension distribution system device and method of tissue approximation using that device to improve wound healing
US7172615B2 (en) 2000-05-19 2007-02-06 Coapt Systems, Inc. Remotely anchored tissue fixation device
US6485503B2 (en) 2000-05-19 2002-11-26 Coapt Systems, Inc. Multi-point tissue tension distribution device, a brow and face lift variation, and a method of tissue approximation using the device
US6575976B2 (en) 2000-06-12 2003-06-10 Arthrex, Inc. Expandable tissue anchor
US8158143B2 (en) 2000-07-14 2012-04-17 Helmholtz-Zentrum Geesthacht Zentrum Fuer Material- Und Kuestenforschung Gmbh Systems for releasing active ingredients, based on biodegradable or biocompatible polymers with a shape memory effect
US6746443B1 (en) 2000-07-27 2004-06-08 Intuitive Surgical Inc. Roll-pitch-roll surgical tool
JP3471004B2 (ja) 2000-08-09 2003-11-25 株式会社医研工業 糸付縫合針の製造方法
CA2418380A1 (en) 2000-08-17 2002-02-21 Tyco Healthcare Group Lp Sutures and coatings made from therapeutic absorbable glass
US20020029011A1 (en) 2000-09-05 2002-03-07 Dyer Wallace K. Methods and devices for surgery
US6746458B1 (en) 2000-09-07 2004-06-08 William G. Cloud Mesh material to repair hernias
US6756000B2 (en) 2000-10-03 2004-06-29 Ethicon, Inc. Process of making multifilament yarn
US6994725B1 (en) 2000-10-03 2006-02-07 Medicinelodge, Inc. Method and apparatus for reconstructing a ligament
US6527795B1 (en) 2000-10-18 2003-03-04 Ethicon, Inc. Knotless suture anchor system and method of use
US20020161168A1 (en) 2000-10-27 2002-10-31 Shalaby Shalaby W. Amorphous polymeric polyaxial initiators and compliant crystalline copolymers therefrom
WO2002038083A1 (en) 2000-10-31 2002-05-16 East Carolina University Tissue lockable connecting structures
EP1341435A4 (en) 2000-11-07 2005-08-17 Artemis Medical Inc TISSUE SEPARATOR DEVICE AND ASSOCIATED METHOD
US6506197B1 (en) 2000-11-15 2003-01-14 Ethicon, Inc. Surgical method for affixing a valve to a heart using a looped suture combination
DE10062881A1 (de) 2000-12-16 2002-07-11 Inst Textil & Faserforschung Nahtmaterial für die Chirurgie, Verfahren zu seiner Herstellung und Verwendung
US20020111641A1 (en) 2001-01-08 2002-08-15 Incisive Surgical, Inc. Bioabsorbable surgical clip with engageable expansion structure
RU2175855C1 (ru) 2001-01-22 2001-11-20 Московская медицинская академия им. И.М. Сеченова Устройство для проведения лигатуры
USD462766S1 (en) 2001-02-16 2002-09-10 Coapt Systems, Inc. Brow lift device
US6783554B2 (en) 2001-02-20 2004-08-31 Atrium Medical Corporation Pile mesh prosthesis
US7048748B1 (en) 2001-03-21 2006-05-23 Uestuener Emin Tuncay Automatic surgical suturing instrument and method
GB0107175D0 (en) 2001-03-22 2001-05-09 Michel David Chassis for grass treatment machine
US20020165555A1 (en) 2001-04-05 2002-11-07 Stein Barry L. Shape memory surgical polypectomy tool
US6776789B2 (en) 2001-04-16 2004-08-17 Todd Bryant Cinch suture and method for using
US20020173803A1 (en) 2001-05-01 2002-11-21 Stephen Ainsworth Self-closing surgical clip for tissue
US20020173822A1 (en) 2001-05-17 2002-11-21 Justin Daniel F. Threaded suture anchor
CA2689598A1 (en) 2001-05-29 2002-12-05 Microvention, Inc. Method of manufacturing expansile filamentous embolization devices
EP1401355A2 (en) 2001-05-31 2004-03-31 Coapt Systems, Inc. Anterior cruciate ligament reconstruction system
US20050065533A1 (en) 2001-05-31 2005-03-24 Magen Hugh E. Apparatus for assembling anterior cruciate ligament reconstruction system
US20040153153A1 (en) 2001-05-31 2004-08-05 Elson Robert J. Anterior cruciate ligament reconstruction system and method of implementing same
GB0113697D0 (en) 2001-06-06 2001-07-25 Smith & Nephew Fixation devices for tissue repair
US7144401B2 (en) 2001-06-07 2006-12-05 Olympus Optical Co., Ltd. Suturing device for endoscope
US7033379B2 (en) 2001-06-08 2006-04-25 Incisive Surgical, Inc. Suture lock having non-through bore capture zone
CN101513356B (zh) 2001-06-14 2013-04-24 苏太克股份有限公司 外科线缝合的设备和方法
US20020198544A1 (en) 2001-06-22 2002-12-26 Renan Uflacker Percutaneous facelift device
US6712859B2 (en) 2001-06-28 2004-03-30 Ethicon, Inc. Hernia repair prosthesis and methods for making same
US7056331B2 (en) 2001-06-29 2006-06-06 Quill Medical, Inc. Suture method
US6599310B2 (en) 2001-06-29 2003-07-29 Quill Medical, Inc. Suture method
GB0116247D0 (en) 2001-07-04 2001-08-29 Univ Loughborough Surgical techniques and devices
US6848152B2 (en) 2001-08-31 2005-02-01 Quill Medical, Inc. Method of forming barbs on a suture and apparatus for performing same
BE1014361A3 (nl) 2001-09-05 2003-09-02 Lille Allebroer Leo Alix De Inrichting voor het verplaatsen van een last, in het bijzonder verreiker of hijskraan.
BE1014364A6 (fr) 2001-09-07 2003-09-02 Collette Michel Organe de suture.
US7029490B2 (en) 2001-09-13 2006-04-18 Arthrex, Inc. High strength suture with coating and colored trace
US6716234B2 (en) 2001-09-13 2004-04-06 Arthrex, Inc. High strength suture material
US20050055051A1 (en) 2001-09-13 2005-03-10 Grafton R. Donald High strength suture with silk trace
US6860891B2 (en) 2001-09-28 2005-03-01 Ethicen, Inc. Arrangement and method for vascular anastomosis
US7294357B2 (en) 2001-09-28 2007-11-13 Tyco Healthcare Group Lp Plasma coated sutures
GB2380205B (en) 2001-09-28 2005-05-18 Falmer Investment Ltd Improvements in and relating to fabric processing
US6648921B2 (en) 2001-10-03 2003-11-18 Ams Research Corporation Implantable article
US8038602B2 (en) * 2001-10-19 2011-10-18 Visionscope Llc Portable imaging system employing a miniature endoscope
GB0125746D0 (en) 2001-10-26 2001-12-19 Cathnet Science Holding Anti-restenosis agent
US6645227B2 (en) 2001-11-21 2003-11-11 Stryker Endoscopy Suture anchor
US6749616B1 (en) 2001-11-21 2004-06-15 Baylor College Of Medicine Surgical system for repairing and grafting severed nerves and methods of repairing and grafting severed nerves
ES2269778T3 (es) * 2001-12-13 2007-04-01 Staubli Ag Pfaffikon Procedimiento y dispositivo para unir varios hilos, en particular extremos de hilos.
US7182771B1 (en) 2001-12-20 2007-02-27 Russell A. Houser Vascular couplers, techniques, methods, and accessories
US20030149447A1 (en) 2002-02-01 2003-08-07 Morency Steven David Barbed surgical suture
DE10208211A1 (de) 2002-02-26 2003-09-11 Mnemoscience Gmbh Polymere Netzwerke
AU2002367772A1 (en) 2002-03-14 2003-09-29 Jeffrey E. Yeung Suture anchor and approximating device
JP3841710B2 (ja) 2002-03-26 2006-11-01 泉工医科工業株式会社 血管用クリップ
AU2003220546A1 (en) 2002-03-26 2003-10-13 Ethicon, Inc. System and method for biopsy management
US7070610B2 (en) 2002-03-30 2006-07-04 Samyang Corporation Monofilament suture and manufacturing method thereof
DE10217351B3 (de) 2002-04-18 2004-02-12 Mnemoscience Gmbh Interpenetrierende Netzwerke
DE10217350C1 (de) 2002-04-18 2003-12-18 Mnemoscience Gmbh Polyesterurethane
EP1501424B1 (en) 2002-04-18 2018-06-06 Helmholtz-Zentrum Geesthacht Zentrum für Material- und Küstenforschung GmbH Biodegradable shape memory polymeric sutures
EP1357714A1 (en) 2002-04-23 2003-10-29 Siemens Information and Communication Networks S.p.A. Method and device for channel estimation in digital radio communication systems
US6951565B2 (en) 2002-04-24 2005-10-04 Linvatec Biomaterials Ltd. Device for inserting surgical implants
US20030204193A1 (en) 2002-04-25 2003-10-30 Stefan Gabriel Suture anchor insertion tool
US6960233B1 (en) 2002-12-10 2005-11-01 Torax Medical, Inc. Methods and apparatus for improving the function of biological passages
WO2003092546A2 (en) 2002-04-30 2003-11-13 Cook Urological Inc. Sling for supporting tissue
DE10219860A1 (de) 2002-05-03 2003-11-20 Ethicon Gmbh Chirurgischer Faden und chirurgisches Implantat mit einem derartigen Faden
US7416556B2 (en) 2002-06-06 2008-08-26 Abbott Laboratories Stop-cock suture clamping system
GB0212976D0 (en) 2002-06-06 2002-07-17 Tonejet Corp Pty Ltd Ejection method and apparatus
CA2487263A1 (en) * 2002-06-07 2003-12-18 Marlen Andreevich Sulamanidze Surgical thread "aptos" for cosmetic surgery
RU2268752C2 (ru) 2002-06-07 2006-01-27 Марлен Андреевич Суламанидзе Хирургическая нить "aptos" для косметических операций
US7232447B2 (en) 2002-06-12 2007-06-19 Boston Scientific Scimed, Inc. Suturing instrument with deflectable head
US8287555B2 (en) 2003-02-06 2012-10-16 Guided Delivery Systems, Inc. Devices and methods for heart valve repair
US7125413B2 (en) 2002-06-20 2006-10-24 Scimed Life Systems, Inc. Endoscopic fundoplication devices and methods for treatment of gastroesophageal reflux disease
US7950559B2 (en) 2002-06-25 2011-05-31 Incisive Surgical, Inc. Mechanical method and apparatus for bilateral tissue fastening
US7112214B2 (en) 2002-06-25 2006-09-26 Incisive Surgical, Inc. Dynamic bioabsorbable fastener for use in wound closure
US8074857B2 (en) 2002-06-25 2011-12-13 Incisive Surgical, Inc. Method and apparatus for tissue fastening with single translating trigger operation
US6726705B2 (en) 2002-06-25 2004-04-27 Incisive Surgical, Inc. Mechanical method and apparatus for bilateral tissue fastening
US20060036266A1 (en) 2002-07-10 2006-02-16 Sulamanidze Marlen A Endoprosthesis for reparative anaplastic surgery
US7063716B2 (en) 2002-07-17 2006-06-20 Tyco Healthcare Group, Lp Uniform stress needle
US8016881B2 (en) 2002-07-31 2011-09-13 Icon Interventional Systems, Inc. Sutures and surgical staples for anastamoses, wound closures, and surgical closures
US6773450B2 (en) 2002-08-09 2004-08-10 Quill Medical, Inc. Suture anchor and method
US7381211B2 (en) 2002-08-21 2008-06-03 Kci Licensing, Inc. Medical closure screen device and method
US7413570B2 (en) 2002-08-21 2008-08-19 Kci Licensing, Inc. Medical closure screen installation systems and methods
US7410495B2 (en) 2002-08-21 2008-08-12 Kci Licensing, Inc. Medical closure clip system and method
US7351250B2 (en) 2002-08-21 2008-04-01 Kci Licensing, Inc. Circumferential medical closure device and method
US7413571B2 (en) 2002-08-21 2008-08-19 Kci Licensing, Inc. Flexible medical closure screen and method
US8707959B2 (en) 2002-09-06 2014-04-29 Koninklijke Philips N.V. Implantable devices, systems, and methods for maintaining desired orientations in targeted tissue regions
US20080066764A1 (en) 2002-09-06 2008-03-20 Apneon, Inc. Implantable devices, systems, and methods for maintaining desired orientations in targeted tissue regions
US7845356B2 (en) 2002-09-06 2010-12-07 Koninklijke Philips Electronics N.V. Implantable devices, systems, and methods for maintaining desired orientations in targeted tissue regions
US8074654B2 (en) 2002-09-06 2011-12-13 Koninklijke Philips Electronics N.V. Implantable devices, systems, and methods for maintaining desired orientations in targeted tissue regions
JP3534108B2 (ja) * 2002-09-17 2004-06-07 株式会社山梨ティー・エル・オー 延伸されたフィラメントの製造方法およびその製造装置および高度に分子配向した極細フィラメント
DE10245025A1 (de) 2002-09-25 2004-04-15 Gerdes Kunststoff-Technik Gmbh & Co. Kunststoffstanzverfahren und Vorrichtungen zur Durchführung des Verfahrens
US20040088003A1 (en) 2002-09-30 2004-05-06 Leung Jeffrey C. Barbed suture in combination with surgical needle
US8100940B2 (en) * 2002-09-30 2012-01-24 Quill Medical, Inc. Barb configurations for barbed sutures
US6905484B2 (en) 2002-09-30 2005-06-14 Damage Control Surgical Technologies, Inc. Method and apparatus for rapid deployment chest drainage
US20040068294A1 (en) 2002-10-04 2004-04-08 Howard Scalzo Braided antimicrobial suture
US6877934B2 (en) 2002-10-28 2005-04-12 Rem Sales, Inc. Milling head for thread whirling
DE10253391A1 (de) 2002-11-15 2004-06-03 Mnemoscience Gmbh Amorphe polymere Netzwerke
WO2004045363A2 (en) * 2002-11-18 2004-06-03 Mediguide Ltd. Method and system for mounting an mps sensor on a catheter
RU2241389C2 (ru) 2002-12-15 2004-12-10 Зотов Вадим Александрович Способ ушивания кожных ран. устройство для ушивания кожных ран
DE10300271A1 (de) 2003-01-08 2004-07-22 Mnemoscience Gmbh Photosensitive polymere Netzwerke
US20040138683A1 (en) 2003-01-09 2004-07-15 Walter Shelton Suture arrow device and method of using
US7232446B1 (en) 2003-01-16 2007-06-19 Farris Alex F Pneumatic suture instrument
GB0303362D0 (en) 2003-02-13 2003-03-19 Enact Pharma Plc Tissue regeneration
US20040167572A1 (en) 2003-02-20 2004-08-26 Roth Noah M. Coated medical devices
WO2004091680A1 (en) 2003-03-31 2004-10-28 Memry Corporation Medical devices having drug eluting properties and methods of manufacture thereof
US6996880B2 (en) 2003-04-01 2006-02-14 Velcro Industries B.V. Fastener elements and methods of manufacture
DE10316573A1 (de) 2003-04-10 2004-11-04 Mnemoscience Gmbh Blends mit Form-Gedächtnis-Eigenschaften
WO2004096305A1 (en) 2003-04-29 2004-11-11 The University Of Hong Kong Coded surgical aids
US7803574B2 (en) 2003-05-05 2010-09-28 Nanosys, Inc. Medical device applications of nanostructured surfaces
US7624487B2 (en) 2003-05-13 2009-12-01 Quill Medical, Inc. Apparatus and method for forming barbs on a suture
US7081135B2 (en) 2003-06-09 2006-07-25 Lane Fielding Smith Mastopexy stabilization apparatus and method
US7150757B2 (en) 2003-06-11 2006-12-19 Fallin T Wade Adjustable line locks and methods
WO2004112853A1 (es) 2003-06-20 2004-12-29 Trevino Schwarz Jose Hilos quirurgicos con inclusión de dientes para su anclaje
US7144412B2 (en) 2003-06-25 2006-12-05 Wolf Medical Enterprises, Inc. Gold suture and method of use in wound closure
USD532107S1 (en) 2003-06-25 2006-11-14 Incisive Surgical, Inc. Tissue fastening instrument
US7972347B2 (en) 2003-06-27 2011-07-05 Surgical Security, Llc Device for surgical repair, closure, and reconstruction
US20040267309A1 (en) 2003-06-27 2004-12-30 Garvin Dennis D. Device for sutureless wound closure
US20050004602A1 (en) 2003-07-02 2005-01-06 Applied Medical Resources Corporation Interlocking suture clinch
EP1646327A2 (en) 2003-07-14 2006-04-19 Dexteus Guard for forceps to avoid accidental needle pricks
ATE447981T1 (de) 2003-07-17 2009-11-15 Bioretec Oy Synthetische, bioabsorbierbare polymer- materialien und implantate
US7021316B2 (en) 2003-08-07 2006-04-04 Tools For Surgery, Llc Device and method for tacking a prosthetic screen
CA2535345A1 (en) 2003-08-13 2005-03-03 Medtronic, Inc. Active agent delivery systems including a miscible polymer blend, medical devices, and methods
US6915623B2 (en) 2003-08-14 2005-07-12 Ethicon, Inc. Method for assembling a package for sutures
CN2640420Y (zh) 2003-08-19 2004-09-15 邵立 美容整形锯齿线
US7691112B2 (en) 2003-09-11 2010-04-06 Nmt Medical, Inc. Devices, systems, and methods for suturing tissue
US7481826B2 (en) 2003-09-30 2009-01-27 Ethicon, Inc. Fluid emitting suture needle
US7678134B2 (en) 2003-10-10 2010-03-16 Arthrex, Inc. Knotless anchor for tissue repair
US7682374B2 (en) 2003-10-21 2010-03-23 Arthrocare Corporation Knotless suture lock and bone anchor implant method
US20050096698A1 (en) 2003-10-29 2005-05-05 Lederman Andrew B. Suture needles and methods of use
JP4556107B2 (ja) * 2003-10-30 2010-10-06 ソニー株式会社 撮像装置及びその方法並びに通信端末装置
CA2543737A1 (en) 2003-10-30 2005-05-12 Applied Medical Resources Corporation Surface treatments and modifications using nanostructure materials
EP1691852A2 (en) 2003-11-10 2006-08-23 Angiotech International AG Medical implants and fibrosis-inducing agents
US7217279B2 (en) 2003-11-14 2007-05-15 Ethicon, Inc. Suture loop anchor
US20050154255A1 (en) 2003-11-20 2005-07-14 The Children's Hospital Of Philadelphia Surgical device
AU2004293463A1 (en) 2003-11-20 2005-06-09 Angiotech International Ag Implantable sensors and implantable pumps and anti-scarring agents
US8257393B2 (en) 2003-12-04 2012-09-04 Ethicon, Inc. Active suture for the delivery of therapeutic fluids
JP4512597B2 (ja) 2003-12-09 2010-07-28 ジーアイ・ダイナミックス・インコーポレーテッド 胃腸管内に固定される装置および固定方法
US7357810B2 (en) 2003-12-18 2008-04-15 Ethicon, Inc. High strength suture with absorbable core and suture anchor combination
US7329271B2 (en) 2003-12-18 2008-02-12 Ethicon, Inc. High strength suture with absorbable core
KR20050072908A (ko) 2004-01-08 2005-07-13 황연희 다방향 다중밀도 주름제거용 봉합사
EP1670362B2 (en) 2004-01-23 2014-10-22 Apollo Endosurgery, Inc. Implantable device fastening system and methods of use
CN1897930A (zh) 2004-01-30 2007-01-17 血管技术国际股份公司 用于治疗挛缩的组合物和方法
US20050197699A1 (en) 2004-02-10 2005-09-08 Jacobs Daniel I. Tissue repair apparatus and method
US20060058799A1 (en) 2004-02-10 2006-03-16 Robert Elson Ligament repair apparatus and method
US20050209612A1 (en) 2004-03-02 2005-09-22 Nakao Naomi L Endoscopic suturing assembly and associated methodology using a temperature biased suture needle
US7057135B2 (en) 2004-03-04 2006-06-06 Matsushita Electric Industrial, Co. Ltd. Method of precise laser nanomachining with UV ultrafast laser pulses
US7513904B2 (en) 2004-03-15 2009-04-07 Marlen Andreevich Sulamanidze Surgical thread and cosmetic surgery method
US20050199249A1 (en) 2004-03-15 2005-09-15 Karram Mickey M. Apparatus and method for incision-free vaginal prolapse repair
US20050209542A1 (en) 2004-03-16 2005-09-22 Jacobs Daniel I Tissue approximation sling and method
WO2005096955A1 (en) 2004-04-07 2005-10-20 Tze Liang Woffles Wu Surgical thread
WO2005096956A1 (en) 2004-04-07 2005-10-20 Tze Liang Woffles Wu Surgical thread
US8236027B2 (en) 2004-04-07 2012-08-07 Tze Liang Woffles Wu Surgical thread
US7645293B2 (en) 2004-04-21 2010-01-12 United States Surgical Corporation Suture anchor installation system and method
NZ598970A (en) 2004-05-14 2013-07-26 Ethicon Llc Suture device using an enlongated body with barbs and a needle at one end and an anchor to prevent pull-through at the other end
US7862583B2 (en) 2004-05-27 2011-01-04 Ethicon Endo-Surgery, Inc. Fusible suture and method for suturing therewith
EP2543341B1 (en) 2004-06-14 2016-07-20 Boston Scientific Limited A soft tissue anchor
RU2007102585A (ru) 2004-06-24 2008-07-27 Филлип Л. ДЖИЛДЕНБЕРГ (US) Полуроботизированный сшивающий аппарат
US7582105B2 (en) 2004-06-30 2009-09-01 Silhouette Lift Societad Limitada Suture for wound closure, tissue approximation, tissue support, suspension and/or fixation
US7468068B2 (en) 2004-06-30 2008-12-23 Alwin Kolster Suture for wound closure, tissue approximation, tissue support, suspension and/or fixation
BRPI0402762C1 (pt) 2004-07-13 2006-04-11 Jose Antonio Encinas Beramendi fio flexìvel para cirurgias reparadoras e dispositivo para sua fabricação
ATE556727T1 (de) 2004-08-03 2012-05-15 Tepha Inc Polyhydroxyalkanoate nähte die sich nicht aufrollen
KR100573222B1 (ko) 2004-08-06 2006-04-24 조성욱 봉합사용 미늘 발생기
EP1778752B1 (en) 2004-08-19 2012-02-15 Tyco Healthcare Group LP Water-swellable copolymers and articles and coating made therefrom
EP1796693A2 (en) 2004-08-26 2007-06-20 Chandrashekhar P. Pathak Implantable tissue compositions and method
US20090105753A1 (en) 2004-08-26 2009-04-23 Prodesco, Inc. Sutures and methods of making the same
US20060058844A1 (en) 2004-09-13 2006-03-16 St. Jude Medical Puerto Rico B.V. Vascular sealing device with locking system
US7244270B2 (en) 2004-09-16 2007-07-17 Evera Medical Systems and devices for soft tissue augmentation
GB2418159B (en) 2004-09-17 2008-02-13 Quill Internat Ind Plc A blasting nozzle
DE102004047974A1 (de) 2004-10-01 2006-04-06 Ethicon Gmbh Chirurgischer Haken
US20060085016A1 (en) 2004-10-15 2006-04-20 Sorin Eremia Suture instrument and method of suturing in cosmetic surgery
US20060089672A1 (en) 2004-10-25 2006-04-27 Jonathan Martinek Yarns containing filaments made from shape memory alloys
US7144415B2 (en) 2004-11-16 2006-12-05 The Anspach Effort, Inc. Anchor/suture used for medical procedures
ITRM20040599A1 (it) 2004-12-06 2005-03-06 Promoitalia Internat S R L Filo chirurgico per operazioni di chirurgia plastica, dermatologiche, estetiche, e per suture chirurgiche.
EP1827245A4 (en) 2004-12-06 2010-01-13 Socovar S E C BINDING COMPONENT
US7572275B2 (en) 2004-12-08 2009-08-11 Stryker Endoscopy System and method for anchoring suture to bone
US20060142784A1 (en) 2004-12-28 2006-06-29 Stavros Kontos Device and method for suturing internal structures puncture wounds
DE102005004317B3 (de) 2005-01-31 2006-06-01 Ethicon Gmbh Gewebeverbinder und Verfahren zur Herstellung
DE102005004318A1 (de) 2005-01-31 2006-08-10 Ethicon Gmbh Chirurgisches Nahtsystem
DE102005006718A1 (de) 2005-02-04 2006-08-17 Aesculap Ag & Co. Kg Resorbierbares chirurgisches Nahtmaterial
US20060207607A1 (en) 2005-02-08 2006-09-21 Mark Hirotsuka System and method for percutaneous palate remodeling
AU2006220565A1 (en) 2005-03-07 2006-09-14 Georgia Tech Research Corporation Nanofilament scaffold for tissue regeneration
WO2006099703A2 (en) 2005-03-21 2006-09-28 Jose Antonio Encinas Beramendi Surgery thread and surgery thread manufacturing device
US7981140B2 (en) 2005-03-30 2011-07-19 Arthrex, Inc. Knotless fixation of tissue to bone with suture chain
US7591850B2 (en) 2005-04-01 2009-09-22 Arthrocare Corporation Surgical methods for anchoring and implanting tissues
US20060229671A1 (en) 2005-04-08 2006-10-12 Musculoskeletal Transplant Foundation Suture anchor and suture anchor installation tool
EP1868485B1 (en) 2005-04-15 2016-06-08 Surgisense Corporation Surgical instruments with sensors for detecting tissue properties, and systems using such instruments
US20060241658A1 (en) 2005-04-20 2006-10-26 Daniel Cerundolo Method and apparatus for suture placement
US7467710B2 (en) 2005-05-04 2008-12-23 Ethicon, Inc. Molded package
US20060253126A1 (en) 2005-05-04 2006-11-09 Bernard Medical, Llc Endoluminal suturing device and method
KR101387070B1 (ko) 2005-05-04 2014-04-18 진테스 게엠베하 결합 부재
EP1887940B1 (en) * 2005-05-06 2013-06-26 Vasonova, Inc. Apparatus for endovascular device guiding and positioning
US10555775B2 (en) 2005-05-16 2020-02-11 Intuitive Surgical Operations, Inc. Methods and system for performing 3-D tool tracking by fusion of sensor and/or camera derived data during minimally invasive robotic surgery
US20060276808A1 (en) 2005-06-06 2006-12-07 Arnal Kevin R Minimally Invasive Methods and Apparatus for Accessing and Ligating Uterine Arteries with Sutures
US20060272979A1 (en) 2005-06-07 2006-12-07 Lubbers Lawrence M Surgical Tray
US9545191B2 (en) 2005-06-13 2017-01-17 Ethicon Endo-Surgery, Inc. Method for suture lacing
US20060287675A1 (en) 2005-06-15 2006-12-21 Prajapati Rita T Method of intra-operative coating therapeutic agents onto sutures composite sutures and methods of use
EP1890638A2 (en) 2005-06-15 2008-02-27 Poly-Med, Inc. Bioswellable sutures
US20060287676A1 (en) 2005-06-15 2006-12-21 Rita Prajapati Method of intra-operative coating therapeutic agents onto sutures, composite sutures and methods of use
US20060286289A1 (en) 2005-06-15 2006-12-21 Rita Prajapati Method of intraoperative coating therapeutic agents onto sutures
US8267961B2 (en) 2005-06-29 2012-09-18 Ethicon, Inc. Barbed suture
AU2006202427A1 (en) 2005-07-13 2007-02-01 Tyco Healthcare Group Lp Monofilament sutures made from a composition containing ultra high molecular weight polyethylene
US20070027475A1 (en) 2005-08-01 2007-02-01 Ancel Surgical R&D, Inc. Scaled suture thread
EP1931702B1 (en) 2005-10-05 2013-01-02 Commonwealth Scientific And Industrial Research Organisation Silk proteins
WO2009050717A2 (en) 2007-10-17 2009-04-23 Surgical Structure Ltd. Fixating means between a mesh and mesh deployment means especially useful for hernia repair surgeries and methods thereof
CA2626014C (en) 2005-10-18 2012-07-10 Cook Biotech Incorporated Medical device with affixation means
EP1959840B1 (en) 2005-10-31 2012-02-08 Ethicon, Inc. Delivery system for a barbed fastener
US7322105B2 (en) 2005-11-18 2008-01-29 Ultradent Products, Inc. Methods for manufacturing endodontic instruments by milling
US20070135840A1 (en) 2005-12-14 2007-06-14 Arthrex, Inc. High strength suture formed of UHMWPE and PBT
US20070141245A1 (en) 2005-12-20 2007-06-21 Steve Tsai System and method for coating filaments
US20070156175A1 (en) 2005-12-29 2007-07-05 Weadock Kevin S Device for attaching, relocating and reinforcing tissue and methods of using same
US20070151961A1 (en) 2006-01-03 2007-07-05 Klaus Kleine Fabrication of an implantable medical device with a modified laser beam
WO2007081876A2 (en) 2006-01-04 2007-07-19 Liquidia Technologies, Inc. Nanostructured surfaces for biomedical/biomaterial applications and processes thereof
CA2632871A1 (en) 2006-01-30 2007-08-09 Angiotech Pharmaceuticals, Inc. Sutures and fibrosing agents
WO2007089878A2 (en) 2006-01-31 2007-08-09 Angiotech Pharmaceuticals, Inc. Sutures and anti-scarring agents
EP1832238A3 (en) 2006-03-07 2008-03-26 Arthrex, Inc. Tapered suture
US20070225763A1 (en) * 2006-03-23 2007-09-27 Ethicon Endo-Surgery, Inc. Marked Suture
US20070224237A1 (en) 2006-03-24 2007-09-27 Julia Hwang Barbed sutures having a therapeutic agent thereon
US20070239206A1 (en) 2006-03-31 2007-10-11 Shelton Frederick E Iv Suture with adhesive/sealant delivery mechanism
US7741273B2 (en) 2006-04-13 2010-06-22 Warsaw Orthopedic, Inc. Drug depot implant designs
US7862582B2 (en) 2006-05-02 2011-01-04 Ethicon Endo-Surgery, Inc. Suture management
WO2007131019A2 (en) 2006-05-04 2007-11-15 Ethicon, Inc. Tissue holding devices and methods for making the same
US8192462B2 (en) 2006-05-16 2012-06-05 Marlen Andreevich Sulamanidze Surgical suture material and method for the application thereof
WO2007145614A2 (en) 2006-06-08 2007-12-21 Eremia Sorin M D Suture instrument and method of suturing in cosmetic surgery
JP4255960B2 (ja) 2006-06-16 2009-04-22 克弥 高須 形成外科用手術糸
WO2008002409A2 (en) 2006-06-26 2008-01-03 Vance Products Incorporated Doing Business As Cook Urological Incorporated Tension free pelvic floor repair
US20080046094A1 (en) 2006-06-27 2008-02-21 Kwang Hee Han Linear tension material for plastic surgery
US9718190B2 (en) 2006-06-29 2017-08-01 Intuitive Surgical Operations, Inc. Tool position and identification indicator displayed in a boundary area of a computer display screen
US8151661B2 (en) 2006-06-30 2012-04-10 Intuituve Surgical Operations, Inc. Compact capstan
US8870916B2 (en) 2006-07-07 2014-10-28 USGI Medical, Inc Low profile tissue anchors, tissue anchor systems, and methods for their delivery and use
US7923075B2 (en) 2006-07-17 2011-04-12 The Hong Kong University Of Science And Technology Methods for preparing nanotextured surfaces and applications thereof
US20090216063A1 (en) * 2008-01-29 2009-08-27 Biocompatibles Uk Limited Bio-absorbable brachytherapy strands
US8480557B2 (en) 2006-07-27 2013-07-09 Refine, Llc Nonaugmentive mastopexy
US20080086170A1 (en) 2006-07-28 2008-04-10 Angiotech Pharmaceuticals, Inc. Minimally-invasive mastoplasty procedure and apparatus
WO2008091386A2 (en) 2006-08-04 2008-07-31 Northwestern University Biomimetic modular adhesive complex: material, methods and applications therefore
US8348973B2 (en) 2006-09-06 2013-01-08 Covidien Lp Bioactive substance in a barbed suture
ES2329092T3 (es) 2006-09-06 2009-11-20 Tyco Healthcare Group, Lp Suturas de puas.
WO2008042909A2 (en) 2006-10-02 2008-04-10 Micell Technologies Inc. Surgical sutures having increased strength
AU2007303137B2 (en) 2006-10-03 2014-04-10 Sinclair Pharmaceuticals Limited Minimally invasive tissue support
US8353931B2 (en) 2006-11-02 2013-01-15 Covidien Lp Long term bioabsorbable barbed sutures
US8128393B2 (en) 2006-12-04 2012-03-06 Liquidia Technologies, Inc. Methods and materials for fabricating laminate nanomolds and nanoparticles therefrom
US20080132943A1 (en) 2006-12-05 2008-06-05 Nicholas Maiorino Knotless wound closure device
US8088124B2 (en) 2007-01-19 2012-01-03 Technolas Perfect Vision Gmbh System and method for precise beam positioning in ocular surgery
US20080195147A1 (en) 2007-02-09 2008-08-14 Tyco Healthcare Group Lp Surface eroding barbed sutures
US20100177184A1 (en) * 2007-02-14 2010-07-15 Chrustie Medical Holdings, Inc. System And Method For Projection of Subsurface Structure Onto An Object's Surface
US20080215072A1 (en) 2007-02-15 2008-09-04 Graham Kelly Methods and apparatus for utilization of barbed sutures in human tissue including a method for eliminating or improving blood flow in veins
EP2120768A1 (en) * 2007-03-07 2009-11-25 Koninklijke Philips Electronics N.V. Positioning device for positioning an object on a surface
WO2008107979A1 (ja) 2007-03-07 2008-09-12 Pioneer Corporation 機器制御システム、機器制御サーバ及び機器制御クライアント
US20080221618A1 (en) 2007-03-09 2008-09-11 Gaoyuan Chen Co-extruded tissue grasping monofilament
WO2008115060A1 (en) 2007-03-20 2008-09-25 Topcon Europe Medical Bv. Apparatus and method for observing an eye, as well as oct-module
US20080281357A1 (en) 2007-05-09 2008-11-13 An-Min Jason Sung Looped tissue-grasping device
ES2644748T3 (es) 2007-05-29 2017-11-30 Ethicon Llc Envasado de sutura
US7976469B2 (en) 2007-06-04 2011-07-12 Medtronic, Inc. Percutaneous needle guide
US8747436B2 (en) * 2007-06-13 2014-06-10 Ethicon, Inc. Bi-directional barbed suture
US8562644B2 (en) 2007-08-06 2013-10-22 Ethicon, Inc. Barbed suture with non-symmetric barbs
US8161618B2 (en) * 2007-09-17 2012-04-24 Tyco Healthcare Group Lp Method of forming barbs on a suture
ATE537857T1 (de) 2007-09-21 2012-01-15 Boston Scient Scimed Inc Medizinische vorrichtungen mit oberflächen mit nanofaser-struktur
ES2398779T3 (es) * 2007-09-27 2013-03-21 Ethicon Llc Suturas de auto-retención que incluyen elementos de retención a tejido con resistencia mejorada
US7956100B2 (en) 2007-09-28 2011-06-07 Abbott Cardiovascular Systems Inc. Implantable medical devices fabricated from block copolymers
US20090099597A1 (en) 2007-10-12 2009-04-16 Isse Nicanor G Suture assembly with tissue engaging elements
US20090112236A1 (en) 2007-10-29 2009-04-30 Tyco Healthcare Group Lp Filament-Reinforced Composite Fiber
US8225673B2 (en) * 2007-10-31 2012-07-24 Ethicon, Inc. Method of manufacturing and testing monofilament and multi-filaments self-retaining sutures
US20110022086A1 (en) 2007-10-31 2011-01-27 Angiotech Pharmaceuticals, Inc. Combining synthetic, natural polymers and recombinant polymers to form monofilament and multifilament self-retaining sutures
US20090143819A1 (en) 2007-10-31 2009-06-04 D Agostino William L Coatings for modifying monofilament and multi-filaments self-retaining sutures
US20090112259A1 (en) 2007-10-31 2009-04-30 Angiotech Pharmaceuticals, Inc. Recombinant expressed bioadsorbable polyhydroxyalkonate monofilament and multi-filaments self-retaining sutures
JP2009118967A (ja) 2007-11-13 2009-06-04 Daitaro Fukuoka 形成施術用糸
DE102007058256A1 (de) 2007-11-26 2009-05-28 Aesculap Ag Chirurgische Fadengeflecht
US9439746B2 (en) 2007-12-13 2016-09-13 Insightra Medical, Inc. Methods and apparatus for treating ventral wall hernia
BRPI0820129B8 (pt) 2007-12-19 2021-06-22 Angiotech Pharm Inc processo de formação de uma sutura autorretentora e sutura autorretentora
US8916077B1 (en) 2007-12-19 2014-12-23 Ethicon, Inc. Self-retaining sutures with retainers formed from molten material
US8118834B1 (en) * 2007-12-20 2012-02-21 Angiotech Pharmaceuticals, Inc. Composite self-retaining sutures and method
DE102008004574A1 (de) 2008-01-09 2009-07-16 Aesculap Ag Chirurgisches Nahtmaterial mit Verankerungselementen
US8615856B1 (en) 2008-01-30 2013-12-31 Ethicon, Inc. Apparatus and method for forming self-retaining sutures
WO2009097556A2 (en) * 2008-01-30 2009-08-06 Angiotech Pharmaceuticals, Inc. Appartaus and method for forming self-retaining sutures
US8888810B2 (en) * 2008-02-20 2014-11-18 Covidien Lp Compound barb medical device and method
US8454653B2 (en) 2008-02-20 2013-06-04 Covidien Lp Compound barb medical device and method
US8273105B2 (en) * 2008-02-20 2012-09-25 Tyco Healthcare Group Lp Compound barb medical device and method
WO2009105663A2 (en) * 2008-02-21 2009-08-27 Angiotech Pharmaceuticals, Inc. Method and apparatus for elevating retainers on self-retaining sutures
US8216273B1 (en) 2008-02-25 2012-07-10 Ethicon, Inc. Self-retainers with supporting structures on a suture
US8641732B1 (en) 2008-02-26 2014-02-04 Ethicon, Inc. Self-retaining suture with variable dimension filament and method
US20090228021A1 (en) 2008-03-06 2009-09-10 Leung Jeffrey C Matrix material
US20090248066A1 (en) 2008-03-28 2009-10-01 David Hjalmar Wilkie Elastic barbed suture and tissue support system
US10376261B2 (en) 2008-04-01 2019-08-13 Covidien Lp Anchoring suture
US8932327B2 (en) 2008-04-01 2015-01-13 Covidien Lp Anchoring device
US20090259251A1 (en) 2008-04-11 2009-10-15 Cohen Matthew D Loop suture
US8864776B2 (en) 2008-04-11 2014-10-21 Covidien Lp Deployment system for surgical suture
JP5619726B2 (ja) 2008-04-15 2014-11-05 エシコン・エルエルシーEthicon, LLC 双方向リテーナ又は一方向リテーナを持つ自己保持縫合材
US20110125188A1 (en) * 2008-04-24 2011-05-26 Angiotech Pharmaceuticals, Inc. Shape-memory self-retaining sutures, methods of manufacture, and methods of use
US9011489B2 (en) 2008-05-14 2015-04-21 Boston Scientific Scimed, Inc. Surgical composite barbed suture
WO2009151876A2 (en) 2008-05-16 2009-12-17 Angiotech Pharmaceuticals, Inc. Coded heterofunctional sutures and methods
US7967841B2 (en) 2008-06-02 2011-06-28 Ethicon, Inc. Methods for using looped tissue-grasping devices
US8888796B2 (en) 2008-06-07 2014-11-18 Ethicon, Inc. Devices for tensioning barbed sutures and methods therefor
US8100941B2 (en) 2008-06-17 2012-01-24 Ethicon, Inc. Collapsible barbed sutures having reduced drag and methods therefor
US8403947B2 (en) 2008-06-17 2013-03-26 Derek H. OCHIAI Method of suturing
CA2765670C (en) 2008-06-24 2018-05-15 Bioactive Surgical, Inc. Surgical sutures incorporated with stem cells or other bioactive materials
US8821539B2 (en) * 2008-07-23 2014-09-02 Ethicon, Inc. Collapsible barbed sutures having reduced drag and methods therefor
US8202531B2 (en) 2008-07-23 2012-06-19 Warsaw Orthopedic, Inc. Drug depots having one or more anchoring members
US10016196B2 (en) * 2008-09-11 2018-07-10 Covidien Lp Tapered looped suture
US8056599B2 (en) 2008-09-24 2011-11-15 Tyco Healthcare Group Lp System and method of making tapered looped suture
US8403017B2 (en) 2008-10-27 2013-03-26 Covidien Lp System, method and apparatus for making tapered looped suture
MX339174B (es) 2008-11-03 2016-05-12 Ethicon Llc Longitud de sutura autorretenible y metodo y dispositivo para su uso.
DE102008057218A1 (de) 2008-11-06 2010-05-12 Aesculap Ag Chirurgisches Nahtmaterial mit im unverstreckten Zustand eingeschnittenen Widerhaken
US8226684B2 (en) 2008-12-22 2012-07-24 Ethicon, Inc. Surgical sutures having collapsible tissue anchoring protrusions and methods therefor
ES2382369T3 (es) 2008-12-30 2012-06-07 Medartis Ag Implante para el tratamiento del síndrome de apnea del sueño
EP2411083A4 (en) 2009-03-23 2013-11-13 Micell Technologies Inc MEDICAL DEVICE FOR DELIVERY OF MEDICAMENT
US8402621B2 (en) 2009-04-29 2013-03-26 Covidien Lp System and method for forming barbs on a suture
WO2011025830A1 (en) 2009-08-25 2011-03-03 Argus Neurooptics, Llc Systems and methods for stimulation of neuronal activity
US9011487B2 (en) 2009-08-27 2015-04-21 Ethicon, Inc. Barbed sutures having pledget stoppers and methods therefor
CN101653355B (zh) * 2009-09-11 2012-01-11 华中科技大学 一种活体小动物成像系统及成像方法
CN101690672A (zh) 2009-09-26 2010-04-07 哈尔滨工业大学（威海） 基于阵列探头的实时光声成像装置
US20110106110A1 (en) 2009-10-30 2011-05-05 Warsaw Orthopedic, Inc. Devices and methods for implanting a plurality of drug depots having one or more anchoring members
CA2781107C (en) 2009-11-16 2019-01-22 Angiotech Pharmaceuticals, Inc. Braided self-retaining sutures and methods
US9398943B2 (en) 2009-11-30 2016-07-26 Covidien Lp Ventral hernia repair with barbed suture
WO2011090628A2 (en) 2009-12-29 2011-07-28 Angiotech Pharmaceuticals, Inc. Bidirectional self-retaining sutures with laser-marked and/or non-laser marked indicia and methods
US9044224B2 (en) 2010-04-12 2015-06-02 Covidien Lp Barbed medical device and method
RU2564358C2 (ru) 2010-04-29 2015-09-27 ЭТИКОН, ЭлЭлСи Самоудерживающиеся шовные материалы с высокой плотностью фиксаторов, и устройства и способы их производства
NZ705330A (en) 2010-05-04 2016-12-23 Ethicon Llc Laser cutting system and methods for creating self-retaining sutures
JP5868958B2 (ja) 2010-05-05 2016-02-24 エシコン・エルエルシーEthicon, LLC 自己保持縫合材用の表面組織構成及びそれを形成するための方法
AU2011265232B2 (en) 2010-06-11 2015-01-22 Ethicon Llc Suture delivery tools for endoscopic and robot-assisted surgery and methods
IT1400838B1 (it) 2010-07-08 2013-07-02 Assut Europ S P A Filo di sutura.
US9220499B2 (en) 2010-10-28 2015-12-29 Covidien Lp Wound closure device including barbed pins
RU2608237C2 (ru) 2010-11-03 2017-01-17 ЭТИКОН ЭлЭлСи Самоудерживающиеся шовные материалы, выделяющие лекарственные средства, и относящиеся к ним методы
US8414612B2 (en) 2010-11-08 2013-04-09 Covidien Lp Multifilament barbed suture
EP3138506B1 (en) 2010-11-09 2020-08-26 Ethicon, LLC Emergency self-retaining sutures
KR101132841B1 (ko) 2011-03-07 2012-04-02 김영재 봉합사
KR101057377B1 (ko) 2011-03-24 2011-08-17 한스바이오메드 주식회사 표면에 미세 돌기를 가지는 의료용 봉합사 및 그의 제조방법
US20130172931A1 (en) 2011-06-06 2013-07-04 Jeffrey M. Gross Methods and devices for soft palate tissue elevation procedures
KR101550103B1 (ko) 2013-11-07 2015-09-03 김춘동 수술용 실의 돌기 형성장치 및 그 방법

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5931855A (en) * 1997-05-21 1999-08-03 Frank Hoffman Surgical methods using one-way suture
US20070005110A1 (en) * 2005-06-29 2007-01-04 Collier John P Braided barbed suture
US20080128397A1 (en) * 2006-11-06 2008-06-05 Unidym, Inc. Laser patterning of nanostructure-films
US20090012560A1 (en) * 2007-04-13 2009-01-08 Angiotech Pharmaceuticals, Inc. Self-retaining systems for surgical procedures
US20090200487A1 (en) * 2008-02-13 2009-08-13 Tyco Healthcare Group Lp Methods of Altering Surgical Fiber

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10779815B2 (en) 2004-05-14 2020-09-22 Ethicon, Inc. Suture methods and devices
US10548592B2 (en) 2004-05-14 2020-02-04 Ethicon, Inc. Suture methods and devices
US11723654B2 (en) 2004-05-14 2023-08-15 Ethicon, Inc. Suture methods and devices
US8915943B2 (en) 2007-04-13 2014-12-23 Ethicon, Inc. Self-retaining systems for surgical procedures
US20110166597A1 (en) * 2007-09-27 2011-07-07 Angiotech Pharmaceuticals, Inc. Self-retaining sutures including tissue retainers having improved strength
US8777987B2 (en) 2007-09-27 2014-07-15 Ethicon, Inc. Self-retaining sutures including tissue retainers having improved strength
US9498893B2 (en) 2007-09-27 2016-11-22 Ethicon, Inc. Self-retaining sutures including tissue retainers having improved strength
US8916077B1 (en) 2007-12-19 2014-12-23 Ethicon, Inc. Self-retaining sutures with retainers formed from molten material
US9044225B1 (en) 2007-12-20 2015-06-02 Ethicon, Inc. Composite self-retaining sutures and method
US10420546B2 (en) 2010-05-04 2019-09-24 Ethicon, Inc. Self-retaining systems having laser-cut retainers
US10952721B2 (en) 2010-05-04 2021-03-23 Ethicon, Inc. Laser cutting system and methods for creating self-retaining sutures
US9955962B2 (en) 2010-06-11 2018-05-01 Ethicon, Inc. Suture delivery tools for endoscopic and robot-assisted surgery and methods
US11007296B2 (en) 2010-11-03 2021-05-18 Ethicon, Inc. Drug-eluting self-retaining sutures and methods relating thereto
US9675341B2 (en) 2010-11-09 2017-06-13 Ethicon Inc. Emergency self-retaining sutures and packaging
US10492780B2 (en) 2011-03-23 2019-12-03 Ethicon, Inc. Self-retaining variable loop sutures
US11690614B2 (en) 2011-03-23 2023-07-04 Ethicon, Inc. Self-retaining variable loop sutures
US10188384B2 (en) 2011-06-06 2019-01-29 Ethicon, Inc. Methods and devices for soft palate tissue elevation procedures
US10470759B2 (en) * 2015-03-16 2019-11-12 Edwards Lifesciences Corporation Suture securement devices
US20160270776A1 (en) * 2015-03-16 2016-09-22 Edwards Lifesciences Corporation Suture securement devices
US11376689B2 (en) * 2016-04-25 2022-07-05 Precitec Gmbh & Co. Kg Beam forming lens system for laser cutting, and apparatus comprising same
US11554446B2 (en) * 2017-06-09 2023-01-17 Bystronic Laser Ag Beam shaper and use thereof, device for laser beam treatment of a workpiece and use thereof, method for laser beam treatment of a workpiece
US11413112B2 (en) * 2017-10-13 2022-08-16 Viscus Biologics, Llc Radiopaque tissue marker
US11819709B2 (en) 2019-02-14 2023-11-21 Videra Surgical Inc. Fiducial marker for oncological and other procedures
US12109432B2 (en) 2019-02-14 2024-10-08 Videra Surgical Inc. Fiducial marker for oncological and other procedures
US20220364848A1 (en) * 2021-05-13 2022-11-17 Industrial Technology Research Institute Depth measurement apparatus and depth measurement method

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